Archives for March 2016


Heart Attacks Can Kill

We rarely hear that heart attacks can kill; we are more likely to hear that a person was brought to the hospital with a heart attack. The doctors placed a stent or two and the person left the hospital two or three days later, fully recovered.

What silent changes occur before a heart attack?

A heart attack does not happen out of nowhere. There can be one or several risk factors present before, like smoking, a lack of exercise, being overweight or obese from eating too much sugar, consuming sugary drinks and eating lots of starchy foods. This will have changed the cholesterol fractions with the bad LDL cholesterol being high and the good HDL cholesterol being low. Triglycerides in this setting are also usually high. The end result is that the lining of the body’s arteries, including the coronary arteries are thickened to the point where blood has a harder time flowing through the opening of the coronary arteries. One day the heart muscle reports severe pain from a lack of oxygen and nutrients. There are essentially three coronary arteries that supply oxygen and nutrients to the heart muscle. For details follow this link.

Often people have 50% to 60% of coronary artery narrowing, but do not know about this. There are tests available that a person could do to check the amount of hardening of the arteries (for instance the IMT test, see below).

What happens after stent placement?

The interventional cardiologist inserts a catheter from a wrist artery or elbow artery backwards through the aorta and from there into each of the openings of the coronary arteries. By injecting a dye X-rays can be made that show the condition of each of the coronary arteries. If a blockage is identified, this can be overcome through angioplasty, where an instrument is used to pierce through the atheromatous deposits and reopen the coronary artery. To prevent re-stenosing, the cardiologist places a wire mesh stent that opens up upon withdrawal of the instrumentation. The end result is that the previously closed off coronary artery is fully functioning again and the stent keeps the previously narrowed coronary artery open. The cardiologist may have to place two or more stents during the same procedure.

A 5-year follow-up study summarized the outcome after stent placements in 1095 patients with 3-vessel coronary artery disease. Percutaneous coronary intervention, a fancy name for saying “angioplasty combined with stent placement” had a 5-year mortality rate of 14.6%, 9.2% heart attack rates and 24.4% reoccurring blockages requiring repeat procedures to reopen the coronary arteries. There were 3% strokes over 5 years demonstrating that not only heart vessels, but also brain vessels were affected by the hardening of the arteries.

What is heart failure?

You may think that the heart would now be entirely back to normal. But this is a gross simplification. The heart functions like a pump, and we know that pumps can fail. In the past when the heart stopped functioning, the person would die. This was the case because there was a complete irreversible closure of one or more coronary arteries. As a result the muscle of one part of the heart, typically involving the left heart chamber would stop functioning. This part of the heart is supplied by the left anterior descending coronary artery. The left heart chamber is the main pump that pushes blood out into the aorta and from there through the whole body. We need the left anterior descending coronary artery to be open and supply nutrients and oxygen to this vital heart pump all the time. When there is a 70% to 80% narrowing of this artery and the heart is not yet failing, there can be life threatening irregular heartbeats, called ventricular fibrillation from a lack of oxygen. This makes the heart muscle contractions no longer effective, as they are no longer synchronized making the heart muscle beat as one unit. This causes acute pump failure and the patients dies. The other possibility is that the patient has a massive heart attack that kills a large portion of the heart muscle off (called myocardial infarction or heart attack). If the patient is not lucky to have immediate access to a hospital with an interventional cardiologist waiting for him or her, even angioplasty and stent placement will not revive the dead portion of the heart muscle and the patient will not survive.

Using a echocardiography the ejection fraction can be determined. This is a measure of how well your heart empties with each heartbeat. Normally it would be between 50 and 70. Below 50 indicates that heart failure is present.

Patients who had a mild heart attack may only have an ejection fraction of 40 and get short-winded with mild activity. Other reasons for mild heart failure can be atrial fibrillation, a common chronic condition in older patients where the atrial chamber is not contracting properly, but fibrillating. Another cause can be inadequate treatment of high blood pressure, so the heart muscle has a hard time keeping up the blood flow against an abnormally high pressure gradient.

Many patients who had a heart attack and were quickly treated with angioplasty and stent insertion have had some minor persistent damage to the heart muscle resulting in abnormal echocardiograms with lowered ejection fractions. In the past without the acute intervention they would likely not have survived. Now due to modern medical technology these patients did survive, but they are left with a mild degree of heart failure, as a certain portion of their heart muscle has died off.

What kills the patient with a heart attack?

As explained above, when the heart muscle no longer is able to function as a pump, the patient dies. This can come from irregular heartbeats, particularly ventricular fibrillation that does not respond to emergency treatment with a defibrillator. This is an electrical device that resets  The reason can also be a heart attack that kills a significant part of the heart muscle. Ventricular fibrillation often occurs when not enough oxygen reaches the heart muscle and the special nerves that coordinate that heart muscle fibers to contract as one unit. Regular monitoring of the carotid intimal-medial thickness (IMT) by ultrasound will give a fairly accurate test for coronary artery hardening as the two are closely related.

A patient in danger of getting into trouble can be referred to a cardiologist and angioplasty and stent placement can prevent further deterioration for the time being. It is much safer to do these procedures electively rather than during an emergency when the patient is in distress.

Prevention of heart attacks, any volunteers?

Following the overview above it becomes apparent that prevention to not get heart disease is the best approach with regard to hardening of the arteries. This can be achieved by doing the following:

  1. You must abandon the Standard American diet. This means no processed food, no refined sugar intake, avoid as much starchy foods as possible. Adopting a Mediterranean diet or a DASH diet is a first step. The DASH diet was developed to help patients with high blood pressure to reduce their blood pressure through the use of this diet. Reducing blood pressure will also reduce the risk of heart disease.
  2. Avoid excessive alcohol intake (more than two drinks per day for men and more than one drink per day for women) as the toxic effect of alcohol kills heart muscle cells. This in turn leads to heart failure.
  3. Regular physical exercise will condition your lungs and heart and improve your cardiac output. By having bigger reserves the person becomes more resilient to developing a heart attack.
  4. Increasing your fiber intake to 30 to 35 grams per day using vegetables and fruit and additional fiber supplements. Common fiber supplements consist of psyllium husk and/or others from the health food store. Take it in the morning with breakfast and with lunch. By avoiding extra fiber at dinnertime you sleep better at night. It turns out that fiber intake is very important to lower LDL cholesterol and triglycerides by interfering with the enterohepatic pathway that leads to recirculation of bile salts rich in these fatty substances. The net results are lower LDL cholesterol and triglyceride levels and higher HDL cholesterol (the good cholesterol) levels.
  5. Take some vitamins and supplements. Vitamin B2, B6, B12 and methyl folate will support methylation pathways. Vitamin D3 in a good dose like 5000 IU per day or more and vitamin K2, 200 micrograms per day will remove calcium out of the arteries and transport it into the bones; this effectively prevents hardening of the arteries and prevents osteoporosis at the same time. Omega-3 supplements (EPA/DHA) are very useful to keep inflammation under control and delay hardening of the arteries; it helps to lower LDL and increase HDL.
  6. Have your hormones checked. Some doctors do not feel comfortable doing this; maybe you want to see a naturopath about it instead. Your body needs the hormone receptors satisfied by adequate bioidentical hormone levels; otherwise you age prematurely and give up body functions that you would rather keep. Normal hormone levels prevent osteoporosis, premature hardening of the arteries, Alzheimer’s, erectile dysfunction and premature wrinkles. The essential hormones involved in cardiovascular disease prevention are thyroid hormones, sex hormones and in some aging people also human growth hormone.
  7. Once every 2 years it would be good to measure your heart function as is outlined in this blog.
  8. There are many more factors that have been identified by researchers to contribute to hardening of the arteries.  It is useful to read this and think about which of these factors may apply to your case.
Heart Attacks Can Kill

Heart Attacks Can Kill


I have explained that hardening of the arteries is the cause of heart attacks. This is caused by a multitude of factors including sugar and processed food overconsumption, smoking, excessive alcohol intake, obesity, undertreated high blood pressure and diabetes. Simply doing angioplasties and placing stents will not stop the process of what led to the heart attack in the first place. Almost 15% died within 5 years following those procedures and 9% got another heart attack. They did not change their diets and stayed inactive. There is another sad aspect about clogging of coronary arteries: the more coronary artery flow we lose through hardening of the coronary arteries, the lower our ejection fraction of the heart as a pump has become. When we reach the point of less than 50% of ejection fraction, we enter disability country with clinical heart failure, forcing us to wear continuous oxygen masks and being unable to exercise or walk. Heart failure is as deadly as terminal cancer having a very high mortality rate.

Concentrate on prevention now, because heart disease remains the number one killer. Remember that we can largely prevent heart disease when we follow the steps mentioned above!

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Book Review: “Healing Gone Wrong – Healing Done Right”, By Ray Schilling, MD

This book entitled “Healing Gone Wrong – Healing Done Right” (Amazon, March 18, 2016) is dealing with the practice of medicine then and now. Medical errors, false diagnoses and wrong treatments are nothing new in the history of medicine. It happened in the past, and it is happening now. My first book dealt with anti-aging and was entitled “A Survivor’s Guide to Successful Aging” (Amazon 2014).

Book overview

Chapter 1 describes that famous people like President Kennedy, Elvis Presley, Churchill, Beethoven or more recently Michael Jackson have something in common: all of them suffered the consequences of blatant medical mistakes. In Beethoven’s time lead containing salves to plug the drainage holes from removing fluid from his abdomen caused lead poisoning. In this chapter I review also how the illnesses of the above-mentioned celebrities were treated, but then ask the question: “What could have been done better to prevent some of the disastrous treatment outcomes?”

Chapter 2 deals with how modern drugs seem to come and go. We learn that twenty-first century medications that are touted as the latest therapeutic agents are having their potentially deadly consequences too: COX-2 inhibitors, the second generation of “improved” arthritis drugs cause strokes and heart attacks! Your doctor may still prescribe some of these dangerous drugs for arthritis now.

Chapter 3 deals with the fact that medical treatments for people’s diseases may be inappropriate when the doctor treats only symptoms, but nothing is done about the causes of their illnesses. This is a scary thought.

Chapter 4 asks the question whether we could learn something from these poor health outcomes in the past, so that we will be able to prevent any disastrous outcomes pertaining to our own health care in the present and future. As we will see, the problem today is still the same as it was in the past, namely that many physicians still like to treat symptoms instead of the underlying cause of an illness. Even though Big Pharma has the seducing concept of a pill for every ill, it is not always in your best interest, when these medications have a slew of side effects. “Gastric reflux” means a mouthful of stomach acid. This is a fact the suffering patient knows already! Big Pharma simply offers the patient with the symptom of gastric reflux a multitude of medications to suppress this symptom. But it is more important to dig deeper to find the reason for the illness and treat the underlying cause.

Chapter 5 concentrates on the brain and how we can keep our brains functioning optimally until a ripe old age. This review spans from prevention of head concussions to avoiding type 3 diabetes (insulin sensitivity from overconsumption of sugar). It manifests itself in Alzheimer’s disease. It is a form of diabetes of the brain that leads to deposits of a gooey substance. Prevention of this condition is also reviewed .

Chapter 6 reviews what we now know about how to keep a healthy heart. Certain ingredients are necessary such as regular exercise, a healthy Mediterranean diet, supplements etc. The good part is that what is good for the heart is also good for the brain. You are preventing two problems (brain and heart disease) at the same time.

Chapter 7 delves into the question why healthy food intake matters. Without the right ingredients of our body fuel, the body machinery will not work properly. The Mediterranean diet is an anti-inflammatory diet that is particularly useful.

Chapter 8 talks about healthy limbs, bones and joints. We are meant to stay active in our eighties and nineties and beyond. No osteoporosis, no joint replacements, no balance problems that result in falls! Learn about how to deal with problems like these in this chapter.

Chapter 9 deals with detoxification. What do we do as we are confronted with pollution, with radiation in the environment and poisons in our daily food? A combination of organic foods, intravenous chelation treatments and taking supplements can help us in that regard.

Chapter 10 deals with reducing the impact of cancer in our lives. A lot of facts have come out in the past 10 years telling us that reduction of sugar and starchy food intake reduces cancer. Curcumin, resveratrol and vitamin D3 supplements also reduce cancer rates as does exercise and stress management. All of this is reviewed here.

Chapter 11 checks out your hormone status. Women need to avoid estrogen dominance; both sexes need to replace the hormones that are missing. By paying attention to your hormonal status and replacing the missing natural hormones with bioidentical ones, most people can add 10 to 15 years of useful, active life!

Chapter 12 is refining some of the thoughts about anti-aging. You will learn about the importance to keep your mitochondrial DNA healthy. Apart from that there are ways how to keep your telomeres longer; certain supplements that are reviewed will help. Also your lifestyle does make a big difference in how old you can turn.

Chapter 13 investigates the limits of supplements. Many supplements are useful, but you do not want to overdo it and get into toxic levels. More is not necessarily better!

Chapter 14 reviews an alternative approach to treating ADHD. Attention deficit and hyperactivity disorder has been over diagnosed, has been neglected and has been over treated with dangerous drugs. An alternative treatment plan is discussed, which includes a combination of therapeutic steps.

Chapter 15 gives you a brief summary of the book.

Kirkus Review

Kirkus Reviews reviewed the book on March 17, 2016: “A retired physician details how various preventative measures can fend off disease and disability in this consumer health guide. Schilling (A Survivor’s Guide to Successful Aging, 2014) had a family medicine practice in Canada for many years before retiring. Although Schilling ventures into some controversial territory in his latest book, it’s generally an engaging, helpful synthesis of ideas that draws on reputable research from the Mayo Clinic and other sources. Overall, it serves as an intensely detailed wake-up call to the importance of preventative health. He largely brings an accessible and even-tempered tone to his narrative, warning readers, for example, that preventative health measures can only aid in “a delay of aging, not ‘eternal living.’ ” A thought-provoking, impassioned plea to be proactive about one’s health.”

Healing Gone Wrong – Healing Done Right

Healing Gone Wrong – Healing Done Right


In this book it becomes evident that it is better to prevent an illness whenever possible rather than to wait for illness to set in and cause disabilities or death. You heard this before: “Prevention is better than a cure” or “an ounce of prevention is better than a pound of cure”. I will give an explanation, based on scientific data that there is indeed evidence to support these notions on a cellular level. The mitochondria, the energy packages within our cells, are the driving force that keep people vibrantly healthy well into their nineties. All this can only happen when the mitochondria function properly. If the mitochondria are poisoned and as a result of toxins malfunction, we are not looking at a person with vibrant health. Instead sixty or seventy year-olds may be confined to a wheelchair. If you want a life without disabilities, a life without major illnesses and enjoy good health to a ripe old age, you are reading the right book.

The book is written in American English.

Available in the US:

In Canada:  

In other countries the book is available through the local Amazon websites.


Fiber, An Essential Food Ingredient

The Standard American Diet will not provide enough fiber, an essential food ingredient. The fiber intake in the US population is between 12.5 grams and 16.8 grams on average, which is way below the recommendations of the Institute of Medicine as listed below.

Depending on age and gender the Food and Nutrition Board, Institute of Medicine, National Academies has recommended the following guidelines for adequate daily fiber intake in grams per person.

Institute of Medicine fiber recommendations (gram per person per day)

Males: age 9-13: 21 grams; age14 to 50: 38 grams; age 51 and higher: 30 grams

Females: age 9-18: 25 grams; age 19-50: 21 grams; age 51 and higher: 21 grams

Children: age 1-3: 19 grams; age 4-8: 25 grams

Brief history regarding fiber

Sir Dr. Denis Burkitt, the famous English surgeon, examined bowel movements (stools) of African tribes in comparison to his English countrymen and came to the conclusion in the 1940’s that the Western world needed to remedy constipation problems and cancer of the colon problems by eating more fiber.

He is still right: fiber is mainly treating the constipation (not preventing the cancer), but the chemicals that are also in the vegetables contain a multitude of natural anti-carcinogenic substances, which provide the powerful preventative action against colon cancer and many other cancers. Lycopene, not known at the time of Sir Dr. Burkitt is one of these and is found in tomatoes and tomato products.

Sir Dr. Burkitt’s observation that high bulk foods (like vegetables and green leaves) prevent cancer is as valid today as it was in the mid 1900’s. In the meantime it has become evident that fiber also lowers cholesterol and helps prevent heart attacks and strokes as well.

What are some of the problems with fiber intake?

Here is a typical day for a Standard American diet:

  1. The average breakfast with two toasts, an egg and sausage. This contains 0.7 grams of fiber. The coffee or tea or juice that is consumed contains no fiber.
  2. For lunch you may eat a hamburger in a bun and a helping of French fries. There are 2 grams of fiber in the bun and 3.9 grams of fiber in the French fries, a total of 5.9 grams. Alternatively you may want to eat a pepperoni medium pizza: 0 grams of fiber!
  3. Dinner may consist of one baked potato (3.4 Grams of fiber), beef steak (0 grams of fiber, no matter whether it is an 8 oz. or 10 oz. steak) and mixed vegetables (1 cup, which contains 5 grams of fiber). For dessert you may have a bowl of ice cream (1 gram of fiber). If you eat in a restaurant you also get a bun with butter (0 grams of fiber) plus a small garden salad (0.9 grams of fiber).
  4. Snacks during the morning: medium oat bran muffin: 5 grams of fiber
  5. Afternoon snack: cinnamon roll: 1 gram of fiber.

Grand total of the day for Standard American diet: 22.9 grams of fiber. It depends whether or not you consumed the mixed vegetables and the bran muffin. If you did not eat the mixed vegetables and the bran muffin, you may only have consumed 12.9 grams of fiber. If you had pizza for lunch, you only got 7 grams of fiber that day.

Sources of fiber from foods

You can see from these few examples that processed foods tend to have a lot less fiber than vegetables and fruit. Particularly pastas and bread are devoid of fiber, but very rich in calories. So, if we were serious about wanting to increase our fiber content in the food we eat, we need to ensure enough intake of fruit and vegetables that contain fiber. There are many useful websites that list the fiber content per food item: if you look for the fiber content of a medium sized apple using this website, you find that it contains 4 grams of fiber.

This would be a much better snack than an ice cream with no or very little fiber. Here are more fiber suggestions.

How can we increase fiber intake?

We need to think about the whole nutritional equation, how many calories are in food, how much sugar, how much fat and protein. If we want to increase the amount of fiber we take in, we definitely have to watch the sugar content of the food item in question.

For instance ¼ cup of raisins has 2 grams of fiber in it, but also 29 grams of sugar, translating into 130 calories. Conversely, ½ cup of raspberries contains 4.6 grams of fiber and has only 20 calories. This choice is definitely a winner compared to raisins.

Use the Internet to learn about the fiber content of the various foods while you keep an eye on sugar content and calories as well. The idea is to maximize the fiber content in your food intake by cutting out fiber empty foods and adding fiber rich foods as much as possible.

Example of a fiber rich day

  1. Breakfast: Omelet with green onions, mushrooms and spinach. Garnish this with ½ avocado and two tablespoons of salsa. The spinach/onion omelet with mushrooms has 3 grams of fiber. ½ avocado provides 5 grams of fiber; the salsa adds 0.6 grams of fiber. Breakfast total: 8.6 grams of fiber.
  2. Lunch: Greek salad with turkey breast (4 grams of fiber). Add a snack of one handful (1.5 oz.) of walnuts as desert: 3 grams of fiber. Lunch total: 7 grams of fiber.
  3. Dinner: Small salad, salmon with broccoli and 1 grilled tomato. Fruit salad for desert. Salad: 0.9 grams of fiber; salmon: 0 grams of fiber; ¾ cup of cooked broccoli: 7 grams of fiber; grilled tomato: 0.6 grams of fiber; fruit salad: 3 grams of fiber. Dinner total: 11.5 grams of fiber.
  4. Snacks throughout the day: 1 pear in the morning: 4 grams of fiber; 1 apple in the afternoon: 4 grams of fiber; 1 handful of walnuts: 3 grams of fiber. Snacks total fiber: 11 grams of fiber.

Total of fiber for the fiber rich day: 38.1 grams of fiber.

Fiber math

This is where it is getting interesting. Depending on whether you are a woman aged above or below 50 years or a man aged above or below 50 years, you have different fiber intake requirements as mentioned above. With the fiber rich diet you have exceeded your daily goal easily whether you are a man or a woman above or below 50. You won the race easily. Fiber intake does not mean that you eat fibrous food that tastes like sawdust! This diet example shows you delicious and nutritious food.

But with the American Standard diet you barely reached the goal if you ate your mixed vegetables and the bran muffin and you are a woman above or below the age of 50. 22.9 grams of fiber is not enough for a child between the ages of 4 and 8 and it is definitely not enough for a man above or below the age of 50. This type of math just shows you how deficient our modern Western type food intake is. And if you look at the aspect of it being delicious or even nutritious it leaves a lot to be desired! This is what Sir Dr. Denis Burkitt found when he compared the food intake of civilized English citizens with tribes in the African jungle. He recognized last century that England’s fiber deprived diet compared to the fiber rich diet in Africa was responsible for the much higher colon cancer rates in England. It is only now that we are recognizing the enormity of his investigations.

Cardiovascular significance of high fiber

Apart from reducing colon cancer incidence fiber has also gained recognition for prevention against heart attacks and strokes. It turns out that the enterohepatic pathway is interfered with through the intake of fiber. Cholesterol from bile is bound to fiber in the gut and transported to the sewer instead of being taken up through the enterohepatic pathway, which incudes the portal vein system and the liver. The end result is that triglycerides and LDL cholesterol fall, while HDL cholesterol (the good cholesterol) is raised, and hardening of the arteries slows down significantly. The patient lives longer, heart attack and stroke rates go down, and there is less disability.

Supplement fiber, if you are not getting enough in food

There is good news. Psyllium husk, Metamucil and any other fiber supplement can help you to reach and surpass your daily fiber goal. There is no danger of overdosing as any surplus simply comes out in your stool. You will notice as you increase your fiber intake that your stool volumes go up. Sir Dr. Burkitt actually weighed the stool of patients in Africa and in England: African tribes had voluminous stools, while people in English had much smaller stool volumes. This is how Sir Dr. Burkitt detected the importance of fiber intake.

Let’s assume you are a male aged 45 years and your diet is a bit better than the average Standard American diet with a daily intake of 25 grams of fiber. Your daily goal is 38 grams of fiber, so you are 13 grams short. You can solve this problem. Get a fiber supplement from the health food store where 1 teaspoon contains about 5 grams of fiber. Be careful: fiber is very thirsty and uses up a lot of water. If you use psyllium husk powder, make sure to add about 1 cup of water to 1 ½ teaspoons of the psyllium husk powder or another similar product. Once you added enough water and stirred well you can drink it down. Between fiber gulps drink some more water to dilute any fiber stuck in your esophagus as it goes down into your stomach. Enough fluid intake is crucial, as the fiber binds fluid in your digestive tract. Repeat this procedure (1 ½ teaspoons of psyllium husk powder with lots of water) at lunchtime. You have now added 15 grams of fiber (2×7.5 grams) to your daily 25 grams of fiber: this brings you to a total of 40 grams of fiber, well above your goal of 38 grams. If you plan to use a fiber supplement it is recommendable that you start with small amounts of fiber (maybe just one teaspoon per day) and increase the amount gradually.

Your alternative would be to switch your diet to the fibre rich diet described above where your basic intake was 38.1 grams, just enough to reach your goal. If you want to play it even safer, you may want to add another handful of walnuts (3 grams of fiber) or ¾ teaspoonful of psyllium husk powder with water to bring your total fiber intake to above 41 grams.

With the introduction of the various fiber products that you can buy at the health food store, it is now much easier to manage your total fiber intake.

Fiber, An Essential Food Ingredient

Fiber, An Essential Food Ingredient


In the past few years we heard from cardiologists that heart attacks, strokes and high blood pressure could all be helped by much higher fiber intakes. But the public in general has not listened very well to this message. Gastroenterologists also have been urging people to eat more fiber for colon cancer prevention, but many other cancers are also diminished by regular fiber intake. Breast cancer is one of these cancers responding to extra fiber intake. The bottom line is that we all need to pay attention to what we eat and learn how little fiber there is in many foods. The tables can be found online, and for some of you it may come as a surprise that a healthy bowl of tossed salad has only very little fiber. If the total fiber content in our food does not add up to what we need (see table above), supplement with psyllium husk powder or another fiber supplement. Do not forget to drink plenty of liquids. This is not only help for those who experience constipation. It is powerful prevention of heart attacks, strokes and many cancers.


Catch Cancer Early

Cancer of the cervix was the first cancer where early diagnosis was practiced and this changed reduced the mortality due to this cancer significantly.

Pap test

When the Pap test was invented and used on a large scale, cervical cancer could be diagnosed at the earliest stage, which is “stage 0” or “cancer in situ” (the earliest local cancer). In 1943 Dr. Papanicolaou published the book “Diagnosis of Uterine Cancer by the Vaginal Smear” where he described in detail how to do the Pap test. This became the norm very quickly and the use of the Pap test spread all around the world following WWII.

This was important, because later it was detected that cure rates of close to 100% could be achieved by removing the tiny accumulation of local cancer cells, which are present with cancer in situ. This could be achieved by surgical removal (cone biopsy), radiation therapy, and cryotherapy or later also with laser treatment. The key to success in cancer treatment is early detection and early treatment.

Other cancer prevention and early detection

  • With melanoma, a darkly pigmented skin cancer, the earliest stage, namely stage 0 or carcinoma in situ is treated by surgical excision leaving a wide margin of healthy skin around it. This is the cure, because it was detected early and had not yet invaded the surrounding tissues.
  • The most common breast cancer type is ductal carcinoma in situ (DCIS), of which 80% are diagnosed by mammography. Treatment for this is usually by local surgical excision, called lumpectomy followed by radiation.
  • Colon cancer typically arises out of colonic polyps. Colonoscopy in high-risk patients with a history of colon cancer in a first degree relative is typically done every three years. Any polyps that are found are removed during the procedure. My mother died at the age 59 of colon cancer. I had colonoscopies every three years since the age of 40 and on several occasions polyps were removed. Had I not had the colonoscopies, an unnoticed carcinoma in situ would have developed within one of the polyps and subsequently invasive colon cancer would have developed. Colonoscopies are a means of true colorectal cancer prevention.

The newest development: Oncoblot test to detect in situ cancers

At the 23rd Annual World Congress on Anti-Aging Medicine in Las Vegas (Dec. 11-13) Dr. Mark Rosenberg spoke about the universal cancer marker ENOX-2 that is only expressed during embryogenesis (the development of the fetus) and in adulthood only again when cancer develops. A test has been developed to check for the ENOX-2 gene, which becomes positive 5 to 7 years before cancer can be detected clinically. This is called Oncoblot test. Sensitivity of ENOX-2 is high and false positives are negligible, which makes the ENOX-2 marker ideal for cancer screening.

There are various isoelectric points for various cancer tissues, so the lab physician can tell the treating physician from which tissue a positive cancer test originates. The interesting aspect is that a combination of green tea and capsicum has been able to suppress the expression of the gene, and the cancer gene can be turned off. Corresponding biopsy samples showed that the cancer cells had disappeared. This is an entirely new concept and will have to be further investigated by clinicians for the various cancer types.

Here are the 25 cancers that are screened with the Oncoblot test: Bladder, Breast, Cervical, Colorectal, Endometrial, Esophageal, Gastric, Hepatocellular (liver), Kidney, Leukemia, Non-Small cell (lung), Lung Small cell, Lymphoma, Melanoma, Mesothelioma, Myeloma, Ovarian, Pancreatic, Prostate, Sarcoma, Squamous Cell, Follicular Thyroid, Papillary Thyroid, Testicular Germ Cell, Uterine. Considering that testing for all of these cancers is 1000 USD, this means that each specific cancer test is only 40 USD per test. I suspect that in future the price will come down as mass screening will be done. But the key is that this test is available right now; it is highly specific and highly sensitive.

But the important finding right now is that we have a very sensitive and very specific cancer screening test for over 25 various cancer types that can detect these cancers in the in situ stage (very early).

This has not been the case in the past except with the introduction of the Pap test for cervical cancer.

Change of treatment protocols may be required

The company producing the Oncoblot test states that the results need to be discussed between patient and treating physician. Although the treatment protocol does not change, there will be a lot more early diagnoses of cancer than in the past. In the past stage 1 and 2 stage cancers were considered to be early cancers and protocols to have these treated have been worked out. But with this very sensitive blood test (Oncoblot test) in situ cancers (stage 0) can be found. Mind you, it sets you back about 1000 USD, the cost for processing your blood and the test. But despite the monetary barrier I believe, that enough people will want this test done, because with the knowledge that cancer is diagnosed, it can be treated effectively with high cure rates.

The down site may be that those who have the test done and are found to be positive may have to undergo additional tests to locate and treat the tumor.

Suggested future approach to cancer detection and treatment

I envisage four steps to the future of cancer diagnosis and treatment.

  1. Screening for cancer using the Oncoblot test and other similar tests that likely will be developed in the future. This will give a tissue specific cancer diagnosis at the earliest possible point in time when clinically in most cases no tumor can be found for another 5 to 7 years.
  2. Staging of the cancer found: this requires confirmation of the cancer by doing imaging studies and possibly biopsies. An MRI scan of the affected area will likely be very useful, also to rule out early lymph gland metastases. Without being certain about the stage of the cancer the treating physician can not be certain what treatment schedule to follow as treatments differ for various stages of a cancer.
  3. Minimal invasive therapy like low-dose laser phototherapy using three different photosensitizers as shown in the example of end stage prostate cancer in this link under the heading “Photodynamic therapy of a group of inoperable prostate cancer patients”. The tragedy in this pilot study was that all of the men presented with end stage prostate cancer, which is difficult to cure. But early prostate cancer is easy to cure with the same method, simply because the cancer cells are local (in situ). Every cancer expert knows that cure rates are very high in the early stages of cancer, with the highest cure rates for cancer in situ (stage 0) and somewhat lower success rates for stages 1 and 2. Stages 3 and 4 have very poor cancer cure rates, as the cancer is already spread into the surrounding area in stage 3 and presents with distant metastases in stage 4. To make an impact in these latter cases requires toxic therapies like chemotherapy, radiotherapy and/or extensive surgery. Having said this, 20% of these end stage prostate cancers still experienced a cure with the triple photosensitizers and low-dose laser therapy (see link above), which conventional therapies would not have achieved.
  4. Retesting for residual cancer using Oncoblot test. Two months after the cancer treatment has been completed, the Oncoblot test should be repeated, which will reassure the patient and physician as well that all of the cancer cells have disappeared. As this test is so sensitive, any remaining cancer cells would shed tumor protein into the blood, which the Oncoblot test would immediately pick up. In the few cases that would remain positive this would enable the physician to do further tests, modify treatment and hopefully get rid of the last cancer cell that way.

Examples of two clinical scenarios

Two common cancers are prostate cancer in men and breast cancer in women.

1. Prostate cancer is very common in older men. From the age of 50 onwards the risk of getting prostate cancer is higher with every decade.

Another problem is that not every prostate cancer is invasive, some cancers are low grade and sit around for a long time and may never metastasize. A cancer expert discusses this here.

To attempt to distinguish between the aggressive form of prostate cancer and the slower “wait and see type”, a score has been developed, called the 4K score. This score combines the PSA test and a prostate specific kallikrein marker within one blood sample. Patients with a high 4K score are the ones who have an aggressive prostate cancer that needs urgent treatment. Patients with a low 4K score are the ones where many urologists recommend to wait and observe.

If I were the patient I would lean towards treating any kind of prostate cancer. Any cancer can do whatever it wants to, and you do not really know how these cancer cells will behave in the future. The only difference in prostate cancer is that the prostate has a tough capsule where the tumor stays localized for a long time, sometimes for decades, but it grows until it breaks out of this shell and metastasizes to the rest of the body. At that point it is often too late to rescue the patient, because it suddenly is a late stage. As stated earlier, late cancer stages are associated with poor treatment successes. Knowing this, I would suggest to use either a radical prostatectomy in a stage I cancer or low-dose laser phototherapy with three photosensitizers and three matching laser frequencies as indicated in the link to my blog mentioned above.

 2. Breast cancer is common in women. Often early cancer is found on a routine mammography or else with the Oncoblot test. An MRI scan can localize the tumor when it has a certain size, but it may take 5 to 7 years following an Oncoblot test to be visualized. This may be a diagnostic dilemma, which has to be worked out in the future. But as most breast cancers develops from the epithelium of the breast ducts, low-dose laser phototherapy with photosensitizers could be given to treat this early cancer stage. If a repeat Oncoblot test 2 months later is negative, the treatment was successful. If not, the clinician will have to closely follow the patient with repeat MRI scans of the breasts. Compared to the present diagnostic system without utilizing the Oncoblot test, this method is still superior, until perhaps in the future another way to localize early cancer becomes available. The fundamental difference between breast cancer and prostate cancer is that breast tissue is very vascular and any cancer of the breast tends to metastasize very early. For this reason it is crucial to treat breast cancer very early to have optimal treatment successes.

Catch Cancer Early

Catch Cancer Early


The introduction of the Oncoblot cancer-screening test may revolutionize diagnosis and treatment of 26 or more cancers that can be screened with this test. I have only highlighted the possibilities with the example of two cancers and explained what this might mean in practical terms. The exciting news is that cancer can now be detected earlier. The confusing part is that it can be diagnosed 5 to 7 years before the cancer is clinical detectable, and many physicians will feel uncomfortable treating cancer that early. Having seen many cancer patients in their end stages in clinical practice, I can only state that you cannot be too early diagnosing cancer. Only stage O (cancer in situ) and stage 1 (and sometimes stage 2) can be treated successfully and guarantee a cure. Experience will teach us what the best way is in the future. In the meantime this is an approach to an early diagnosis without taking any risks.