Jun
29
2013

Aging And Lack Of Hormones Matter, Not Evolution

Recently a story went through the media regarding the findings of a research group from McMaster University, Hamilton/Ont. that described that as men were dating younger women evolution took fertility away from aging women. It sounds to me that this research, which included computer modelling  was mainly driven by sociological observations. Some older males may seek out female partners that have the same age as their daughters, which seems to be considered “socially acceptable”. Contrary to that successful relationships of older females with younger partners are often met with less tolerance! It seems that medical facts like hormonal changes that are behind behaviors have not been taken into account. The following blog is meant to give you a background of hormonal changes for both sexes as we age and what can be done today to reset the clock for males and females alike to an age between 30 and 35, which creates a “level playing field”. It is a 101 on bio-identical hormone replacement.

Depleting hormones due to aging

Both men and women experience a slow decrease in hormone production beyond the age of 30, but the depletion occurs somewhat faster in women than in men. As a result women get menopause at the age of 45 to 55 (cessation of periods and postmenopausal symptoms) and men get into andropause (the male equivalent of menopause) at the age of 55 to 65. The main symptom of andropause is erectile dysfunction. These are acceptable simple physiological facts that have been known to endocrinologists since the 1950’s to 1960’s. Common sense would suggest that replacing missing hormones with bioidentical hormones should bring the body chemistry back to normal. However, this is not what conventional medicine has done. Instead, Big Pharma got wind of how powerful hormones were, and they developed hormone-like substances that could be patented and produced on a large scale. What they did not disclose initially was the fact that non-bioidentical hormones with side-chains and chlorine or fluoride atoms in the molecules would cause heart attacks, strokes and blood clots. An example of this is Premarin, an estrogen concoction that is derived from pregnant mares and Provera, a “progesterone-unlike” synthetic product, both of which were used for HRT (“hormone replacement therapy”).

Aging And Lack Of Hormones Matter, Not Evolution

Aging And Lack Of Hormones Matter, Not Evolution

Results of the Women’s Health Initiative (using synthetic hormones)

As there were conflicting reports about the benefit of hormone replacement after menopause in the medical literature, the National Institutes of Health funded a large study (the Women’s Health Initiative) to clarify what was going on with regard to side effects and effects of HRT. Unfortunately, synthetic non-bioidentical hormone products were used in these studies (Premarin and Provera) instead of bioidentical estrogen and progesterone. The results of the Women’s Health Initiative were devastating. In 2002 doctors  were warned that Premarin and Provera used as HRT would cause increased heart attack rates and breasts cancer, which led to premature death. Overall the placebo group did better than the experimental group and this is why the trial was prematurely stopped.  As a result of the wide publicity regarding the negative results of the Women’s Health Initiative postmenopausal women either do not see their physician for hormone replacement or are advised by conventional doctors that only small amounts of Premarin could be used for not more than 5 years for fear of causing breast cancer. Medico-legal considerations are at play and the whole issue of HRT after menopause has been politicized.

Facts about bioidentical hormone replacement therapy (BHRT)

The key with menopause or andropause is to accurately determine what the hormone levels are, which requires saliva hormone tests, not blood tests. The results are compared to what is normal for a 30 to 35 year-old person and missing hormones are replaced with bio-identical hormones as originally suggested by Dr. John Lee some time ago. Briefly, he mentioned 3 fundamental rules in bioidentical hormone replacement: first, only replace those hormones that are missing; secondly, use bioidentical hormones instead of synthetic hormones and thirdly, use the smaller doses that are enough to replace the normal hormone levels that the body had around your mid thirties, don’t over treat. He also stated that lifestyle issues like poor diets, excessive alcohol intake, stress and insulin resistance (from obesity) needed to be addressed. His recommendations are still valid today, as hormone facts have not changed.

So, the physician or naturopath needs to use common sense and replace what is missing with bio-identical hormones (not with synthetic hormone-like drugs that make the patient sick). If this is done properly, a normal sex life persists in both males and females and both age at a much slower pace without the development of heart attacks, strokes or osteoporosis. When hormones are rebalanced and a proper diet and regular exercise are also adhered to, diseases like diabetes, cancer, osteoporosis, heart attacks, strokes, arthritis or high blood pressure do not develop. In other words disabilities are prevented and you are able to enjoy an active life in vibrant health.

More info on bioidentical hormone replacement

Eventually all of us, male or female succumb to the hormone deficiencies that are associated with aging. As long as the hormones are still produced, males will have a normal sex drive, but 10 or 20 years beyond the point where their partners entered menopause erectile dysfunction will eventually set in. Just taking Viagra is no substitute for the missing testosterone and other hormones. Without paying attention to hormone restoration the biological clock is ticking and we will get the diseases mentioned above that lead to premature death. On the other hand with male hormone restoration (bioidentical testosterone) the body chemistry and physiological functions return to how they were in his 30’s. The same is true for female hormone restoration (using estriol/estradiol and progesterone).

The irony is that back in the 1960’s and 1970’s in Europe bioidentical hormone replacement was already suggested and practiced by a small number of physicians with amazing success. One of these doctors is Dr. Hertoghe, an endocrinologist in Belgium. They were able to show then that women could regain their sexual desire and their vitality with bioidentical hormone replacement (BHRT). For some reason (could it be greed?) Big Pharma and various government agencies were able to get the upper hand and suppress this knowledge all with the notion that factory produced hormones would be of a “higher quality” than bioidentical hormone creams from compounding pharmacies. Fortunately these lies have been exposed in numerous publications and the information is now more easily accessible through the use of the Internet. But Big Pharma still tries to intimidate and twist the truth! Here is a recently published prospective study over 3 years involving 300 women from Texas (Women’s Wellness Center, Tyler, Texas, USA) that showed anti-inflammatory effects and anti-anxiety effects with bioidentical hormone replacement. It also showed that no biochemical changes took place that would have caused changes in fibrinogen levels affecting clotting, inflammation to cause heart attacks or other indications to cause cancer. This confirms what Moskowitz had stated in 2006 about the safety of bioidentical hormones.

The irony is that for male hormone replacement with testosterone a lot of the hormone preparations produced by Big Pharma are actually bioidentical testosterone products. It is with women’s hormones that Big Pharma made substantial chemical modifications so that the final products did not fit the estrogen and progesterone receptors, causing heart attacks, blood clots and breast cancer.

Both women and men should get a saliva hormone panel test measuring DHEA-S (storage form of DHEA), estradiol, testosterone, progesterone and cortisol from one sample test tube when they become hormone deficient. Typically a woman should get tested first around the age of 35 to 40, a man around the age of 45 to 55. The treating physician or naturopath can then decide, whether bioidentical hormone replacement is necessary. If so, only what is missing is replaced with bioidentical hormone creams from a compounding pharmacy to the point where the hormone levels would have been around the age of 30 to 35 according to the principles by Dr. Lee. For A4M physicians this is a routine that is familiar. Your regular physician will likely feel uncomfortable, but many naturopaths will feel very comfortable doing this.

Discussion of the evolutional study of McMaster University

Although it may sound intriguing to rationalize that older men like to date and marry younger women, in my medical opinion these researchers got it wrong. As hormone weaknesses manifest themselves perhaps 10 years later in men than in women (in some men even 20 years later), older men may find themselves without a sex partner in their own age group, if women of their age do not use bioidentical hormone replacement. The McMaster team should have done their research including a control group with men and women who used bioidentical hormone replacement. They likely would have noticed that the sex drive of older women on bioidentical hormone replacement would still be the same as that of younger women in their 30’s. Also, the “aging clock” would have slowed down in these women, which in turn would probably have resulted in a different behavior pattern among the older males.

References

1. Why choose bioidentical hormones: http://www.empowher.com/menopause/content/bioidentical-hormones-vs-synthetic-hormones-what-s-difference

2. Anti-Aging Medicine for Women and Men: http://www.nethealthbook.com/articles/antiagingforwomenandmen.php

3. Menopause: http://www.nethealthbook.com/articles/menopause.php

4. Andropause: http://www.nethealthbook.com/articles/malemenopauseandropause.php

5. 2009 Postgraduate Medicine article on the bioidentical hormone debate: http://www.ncbi.nlm.nih.gov/pubmed/19179815

Last edited June 29, 2013

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About Ray Schilling

Dr. Ray Schilling born in Tübingen, Germany and Graduated from Eberhard-Karls-University Medical School, Tuebingen in 1971. Once Post-doctoral cancer research position holder at the Ontario Cancer Institute in Toronto, is now a member of the American Academy of Anti-Aging Medicine (A4M).