Jun
09
2018

What Makes Chips Addictive?

When you emptied an entire bag of potato chips, you may ask yourself: what makes chips addictive? Scientists talk about hedonic hyperphagia or hedonic hunger. In plain English, it is the pleasure of eating, even when you are not hungry. There are certain foods that seduce you to overeat, and one of these are chips. Chocolate or candy can be other high-hedonic rating foods.

Erlangen experiments

A group of researchers from the Erlangen University in Germany set out to get to the bottom of this addiction eating. 17 healthy subjects with a body mass index of between 19 and 27 were recruited for eating experiments. They got either high calorie chips or low calorie zucchini. The chips created a marked stimulation on a functional MRI scan where the nucleus accumbens was lighting up. When they consumed zucchini no such stimulation could be documented. The researchers had done similar experiments with the same foods on rats. They too had functional MRI scans and the tests showed similar stimulation after the test animals consumed chips, but not after zucchini.

Nucleus accumbens, the addiction center for food

Professor Andreas Hess and his team in Erlangen say that the nucleus accumbens is the addiction center for food. They also did experiments with fat to carbohydrate composition to find the most addictive mixture. There is a certain fat to carbohydrate ratio that triggers food addiction. What surprised the Erlangen researchers was that both in rats and humans the optimal addiction potential was identical.

  • They found that rats preferred 35% of fat and 45% of carbohydrates in their chips. With humans there is the other factor: on top of the fat/carb mixture we like to taste some salt and spices, because this also will stimulate our appetite. The food industry has figured this out long time ago. This knowledge from tasting experiments is built into processed food.
  • The Erlangen researchers  also found that in obese people the nucleus accumbens was lighting up more intensely the higher the BMI was. That means that obese people are more food-addicted!

Triggering the nucleus accumbens

  • Professor Hess postulates that the 35% fat to 45% carb mix in potato chips is ideal for the body. It can mobilize quick energy from carbs, but also have storable energy from fat at the same time. It is this mix, which stimulates the addiction center in the nucleus accumbens.
  • In a study from Bethesda, Maryland researchers found an overlap between food addiction and drug addiction.  The common pathways in both is the release of dopamine in the nucleus accumbens. This dopamine release makes us feel good, and as a result, we want to experience it again.
  • In this study patients with bulimia nervosa were examined. They found that   overconsumption of sugar-laden foods had very similar effects as drugs in drug-addicted patients. It is the release of dopamine, glutamate and the opioid system that are involved in both. The nucleus accumbens is also receiving stimulation in both situations.

What can be done about food addiction?

This publication noted that people who are food addicted eat higher amounts of fat and carbohydrates. With this mix the feel-good nucleus accumbens produces most dopamine, which is the driving force behind the addiction.

  • If you cut out sugar, you find it easier to control your eating portions. But you also must cut out processed food, as this is where a lot of hidden sugar is coming from.
  • Cut down on your fat consumption. Even if you reduce it from 35% to 10% or 15%, this is a huge step forward. It reduces your calorie intake significantly, but also reduces the stimulation of your appetite center.
  • Eat lots of vegetables, salads and some fruit. Be careful with some fruit like grapes, bananas, mangos, papayas and dates. They are all higher in sugars. If you cannot entirely avoid those, use portion control, so you are not overeating on them.

Portion control

Besides changing the food quality, you can reduce the portions of food you are eating. Instead of mindlessly emptying a whole bag of chips, you could get a small bowl and fill part of the bag of chips into it. Remove the bag into a cupboard that is difficult to reach. If you are sitting and watching TV, you could eat one chip at a time, but only during commercial breaks. This way your chip eating becomes more conscious and more controlled, and you set a limit. In time you may find that you can replace the chips with a lower calorie food like slices of apples, celery sticks or carrot sticks.

What Makes Chips Addictive?

What Makes Chips Addictive?

Conclusion

Researchers found that chips were addictive in rats and in humans. Functional MRI scans of brains in rats and humans showed that potato chip eating stimulated the nucleus accumbens. It was lighting up in both species when the test subjects consumed potato chips. Surprisingly, it did not matter, whether these were test animals or humans! A review of several research papers showed a similarity between food addiction and drug addiction. It is dopamine and other brain transmitters that stimulate the nucleus accumbens, which is the addiction center. One of the keys, professor Hess from Erlangen University in Germany found, is the fat/carb mix. When the potato chips contained 35% fat and 45% carbs, this stimulated the nucleus accumbens.

Changing your eating habits

Knowing all of this helps us to be able to change our eating habits. To avoid the pitfalls of food addiction, cut out sugar and starchy foods, and remove processed foods from your diet. Also reduce some of the fat to 10% or 15% fat in your total diet. Eat lots of vegetables and fruit low in sugar. In addition you should also consider with portion control to avoid mindless munching. Before you know it you can shed the pounds that you may have accumulated before. You will be able to reduce your BMI to 21 to 23. Many people have done it before you.

Mar
10
2018

Dementia From Excessive Alcohol Abuse

A new study from France documented dementia from excessive alcohol abuse. One million patients who needed admission to hospitals in France for early dementia took part in that study. This was based on this publication. Dementia is a clinical syndrome, where the cognitive ability deteriorates progressively.

The study from France regarding dementia from excessive alcohol abuse

According to the French National Hospital Discharge database it was especially relevant that alcohol use disorders were present in 16.5% of the men and 4% of the women with dementia. Those who did not have the diagnosis of dementia had only half the amount of alcohol abuse disorders in both sexes.

There are other diseases that can lead to dementia like Parkinson’s disease and Huntington’s disease. These cases were not part of this study.

The association with alcohol abuse was particularly evident in early dementia cases at an age below 65.

Furthermore, alcoholics also have a shorter life expectancy.

Several mechanisms responsible for dementia development

Alcohol can cause dementia in several ways.

  • First of all, alcohol and the metabolic by-product acetaldehyde have toxic effects on the brain. They cause long-term toxic effects and functional brain damage is the result.
  • Furthermore, heavy alcohol abuse leads to liver damage with resulting changes in metabolism. Ammonia production from the cirrhotic liver causes brain damage in a condition called hepatic encephalopathy.
  • In addition, heavy drinking is a strong vascular risk factor. This leads to diabetes, high blood pressure, heart attacks and strokes.
  • Often it is the population group that is uneducated, people who smoke and people with depression who suffer from the effects of alcohol abuse.
  • Finally, heavy drinking is more frequent in men than in women. In men the dementia risk was 4.7-fold, in women 4.3-fold.
  • Obesity, smoking and high blood pressure are also risk factors for dementia. If these cases were not part of the study, heavy alcohol abuse caused an increase in dementia in both sexes by a factor of 3-fold.

Possible biases of the study

Dr. Kostas Lyketsos, a neuropsychiatry professor and director of the John Hopkins Memory and Alzheimer’s Treatment Center did not take part in the study and its investigation. A non- biased observer, Dr. Kostas Lyketsos stated that there is a problem with precision of the data the larger the study population is. In this case there were more than 1 million participants, so a number of biases can influence the outcome of the study. For instance, one problem is that these patients with mild cognitive impairment were inpatients in a hospital. Normally such patients would not be in a hospital. Another fact was that none of the participants had received questionnaires of the amount of alcoholic drinks they consumed, and as a result it is difficult to knows exactly how high the amount of alcohol was that caused the damage to the brain.

Country bias

The large sample size was from only one country, France. This means that we do not know whether there would be ethnic differences between countries. Nevertheless the findings of this study are important. In a 2014 review by the WHO the average person in France consumed 12.2 liters of pure alcohol per year. In contrast the average person in the US consumed only 9.2 liters of pure alcohol in this year. Apart from these concerns it is important to realize that alcohol has toxic effects on the brain. This can also result in dementia.

Other studies regarding alcohol abuse and dementia

The media has praised alcohol for preventing heart attacks. On the other hand, there are other articles in which we hear about alcoholic hepatitis and liver cirrhosis, both of which can be killer diseases. To get some clarification, let us examine the various facts.

Dr. Finnel mentioned that 7.9% of all emergency room visits in the US are due conditions which have an association to alcohol(Ref.1). When the causes of deaths  that are a consequence to alcohol are listed, they are: cancer of the mouth and pharynx, alcohol abuse disorders, coronary heart disease causing heart attacks, cirrhosis of the liver, traffic accidents, poisonings, falls and intentional injuries. You don’t get that from the news. Instead you read about the one glass of red wine per day that is good for women and up to two glasses of red wine that is good for men to prevent heart attacks and strokes.

Bioflavonoids

It is the bioflavonoids and among those in particular resveratrol, that are the active ingredient responsible for heart health.

Resveratrol is a powerful antioxidant that protects against ischemia-reperfusion injuries.  It is responsible for the cardio protective properties of red wine known as the “French paradox” (Ref.2). According to this reference resveratrol contributes to at least 3 processes that stabilize the metabolism.

Toxicity of alcohol

According to the WHO 5.9% of all deaths worldwide is a consequence of alcohol overconsumption.  In 2012 the WHO recorded that 7.6% of deaths in males, but only 4% of female deaths were due to alcohol. Toxicity comes from the breakdown product acetaldehyde, which all cells can convert from alcohol. Liver cells are especially able to do that. According to Ref. 3 alcohol diffuses easily through all of the cell membranes and reaches every organ in the body. The toxicity of acetaldehyde is shutting down the mitochondria, which affects the energy metabolism and causes cell death. The immune system reacts with inflammation, when it attempts to repair the damage.

So, what are the major damages which alcohol can cause? First there is fat accumulation (steatosis), next chronic inflammation followed by necrosis (dying of cells) and finally fibrosis. An example of fibrosis is liver cirrhosis, where non-functioning connective tissue replaces liver cells.

Different tissue sensitivity to alcohol

Certain tissues are more susceptible to alcohol toxicity than others. As the concentration of alcohol is highest in tissues that are in direct contact with alcoholic drinks, cancers related to alcohol consumption develop in the oral cavity, pharynx, larynx, esophagus, and in the colon and rectum. The pancreas is particularly vulnerable to inflammation and fibrotic changes with degeneration into cancer of the pancreas. The heart tissue and the arteries are very sensitive to alcohol.  Hypertension, heart attacks, stroke, cardiomyopathy and myocarditis as well as irregular heart beats (arrhythmias) can develop. The brain is very sensitive to toxic effects of alcohol as well. This causes major depression, personality changes with violent behavior, car accidents and injuries.

Other toxic effects of alcohol on organs

Kidney disease (alcoholic nephropathy) is another illness due to too much alcohol. Five percent  of breast cancers in northern Europe and North America are a direct consequence to the toxic effects of alcohol (Ref.3). Finally, the liver being so active in detoxifying alcohol, will be not functioning and finally develops liver cirrhosis, as described before. This accounts for a lot of premature deaths at a relatively young age (typically in the mid to late 50’s).

Ref. 3 goes on to say that literature exists which claims that 1 to 2 drinks per day would be useful for prevention of heart disease. But the observation of the authors is that people will not discipline themselves to stick to these limits and very quickly enter into the zone of alcohol toxicity. The authors further noted that with regard to causing any kind of cancer there is no safe lower limit; the risk is directly proportional to the amount of alcohol consumed and the risk starts right above the zero point.

The pathologist has the last word

When I studied medicine at the University of Tübingen, Germany I attended lectures in the pathology department where Professor A. Bohle, M.D. demonstrated pathology findings of deceased patients. Dr. Bohle had a special interest in Mallory bodies. These are alcohol inclusion cysts within liver cells that can be stained with a bright red dye.

Histological documentation of toxic effects in livers of corpses

I will never forget when Prof. Bohle pointed out that the livers of this most diverse population, whose bodies we had the privilege as medical students to study, had a rate of 25% positive Mallory bodies. He wanted to impress on us as medical students to watch out for the alcoholics that are usually missed in general practice. Obviously 25% of the pathology population was affected by the consumption of alcohol. It was Prof. Bohle’s hope that we could perhaps interfere on the primary care level before things went out of control. Many of these corpses were the sad results of traffic accidents that could have been prevented. (In 2018 things have changed: seat belts and alcohol limits are standard, in 1968 in Germany they were not).

Alcohol as an aging substance

Consistent use of alcohol on a regular basis will slow down cell metabolism and hormone production significantly. The major effect of alcohol leads to poisoning of the mitochondria in multiple organs, which translates into faster aging and a shortened life expectancy. This in turn results in a change of appearance. An older person who has abused alcohol for a number of years may look 5 to 10 years older than their chronological age.

50% of people above the age of 65 drink daily (Ref.4). Some more statistics: alcohol abuse in elderly men is 4-times higher than in elderly women. 5% to 10% of all dementia cases are related to alcohol abuse. About 15% of older adults are experiencing health risks from abusing alcohol. And about 90% of older adults are using medications. Close to 100% of medications can adversely interact with alcohol (Ref.4).

Social pressure

These are the scientific facts, and then there is social pressure, when you are invited to a party.

When you are young and believe that you are invincible, do you care what the science says? You want to have a “good time” and not worry about consequences. The data about long-term exposure and a slowly increasing cancer risk is there. The wine industry will remind you that 1 drink for women and two drinks for men will protect you from heart attacks. They will withhold the cancer information from you, as they don’t really want to hear about that (yes, it’s bad for their business!).

Resisting social pressure and doing what is good for you

Can you have a good time at a party without drinking alcohol? Yes, you can. You can talk and you can listen; you are probably more with it than those who had too much to drink. I like mineral water and hold on to a glass of that.

I explained in a blog before how I was convinced by three speakers at an A4M conference to join those who abstain from alcohol.

Socializing without alcohol is doable. You may at times miss it, but you can warm up even to a crowd that had a few drinks too much. It is about choice: we can choose what we want out of life.

 

Dementia From Excessive Alcohol Abuse

Dementia From Excessive Alcohol Abuse

Conclusion

Alcohol is a cell and nerve poison. The medical need for “one glass of wine for women and two glasses of wine for men to prevent heart attacks and strokes” has been vastly exaggerated. Fact is that resveratrol and other antioxidants like vitamin C and vitamin E can also prevent cardiovascular disease. They are alcohol-free! The risk of dementia development as a long-term result of alcohol exposure is something that is only now getting attention by the medical profession. We live longer these days, and this makes alcohol exposure over the decades a real threat to our mental wellbeing. Consumption of alcohol needs to be re-evaluated by every one of us. What risks are we willing to take? Is the stress-relieving effect of alcohol worth the risk of losing our mind to Alzheimer’s disease? If we care about our future the answer should be clear!

References

Ref. 1: John T. Finnell: “: Alcohol-Related Disease“ Rosen’s Emergency Medicine, Chapter 185, 2378-2394. Saunders 2014.

Ref. 2: “Hurst’s The Heart”, 13th edition, The McGraw-Hill Companies, Inc., 2011. Chapter 54. Coronary Blood Flow and Myocardial Ischemia.

Ref. 3: Ivan Rusyn and Ramon Bataller: “Alcohol and toxicity”, 2013-08-01Z, Volume 59, Issue 2, Pages 387-388; copyright 2013 European Association for the Study of the Liver.

Ref. 4: Tom J. Wachtel and Marsha D. Fretwell: Practical Guide to the Care of the Geriatric Patient, Third Edition, Copyright 2007 by Mosby.

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Mar
03
2018

Foods That Can Protect You From Cancer

There are foods that can protect you from cancer. Generally speaking you want to remove cancer-producing substances from your diet. But diet is only part of your lifestyle that can contribute to cancer. I will list some of the more important dietary factors below and briefly also touch on important other factors.

Avoid burning your meat 

When you use the BBQ, avoid burning your meat. As a matter of fact it is a lot better to use a slow cooker at low heat, and cook the meat for a longer time. In this way you won’t create carcinogens, which are cancer-producing chemicals. Healthy Grilling Tips to Minimize Carcinogens in Your Food. This is particularly important for the red meats (like beef, lamb, bison or pork).

Sugar can cause cancer

You never thought that sugar and an overabundance of starchy foods can cause cancer, but they do. 5 Reasons Cancer and Sugar are Best Friends.  What is the reason for this? The answer is found in the metabolism of cancer cells. Cancer cells use 10- to 12-times more sugar for their metabolism than normal cells.  Over-consuming sugar is the worst thing a cancer patient can do. Replace sugar by stevia, which is a harmless sweetener. It does not lead to an insulin reaction. You need to avoid all other sugar substitutes as there are other health problems associated with them.

Avoid macaroni and cheese because of phthalates

Avoid macaroni and cheese: Phthalates are found in almost every sample of cheese powder used to manufacture macaroni and cheese. Phthalates can cause infertility and breast cancer. Toxic effects of the easily avoidable phthalates and parabens.

High fat diet

A high fat diet increases the risk for breast cancer: High-Fat Diet Increases Breast Cancer Risk, Study Finds. Limit your fat intake to about 10% of saturated fat. That is the recommendation of the FDA: New FDA Food Guidelines – Medical Articles by Dr. Ray. Increase your consumption of fish and seafood. Only one proviso: predator fish like shark, marlin, tilefish, swordfish and grouper are high in mercury. But wild salmon, sardines and oysters are low in mercury; so are shrimp and squid. Before You Buy Fish, Check This Mercury Level List.

Take high dose vitamin D3 supplements

In order to avoid cancer, take high dose vitamin D3 supplements to avoid cancer. Vitamin D3 in cancer prevention and therapy: the nutritional issue. Strong statistics exist showing that vitamin D3 is a powerful tool to lower your risk of developing cancer. Your family doctor should take a blood test called 25-hydroxy vitamin D level to monitor that you absorb enough vitamin D3. Some people absorb vitamin D3 slowly and fast absorbers absorb it more rapidly.  The only way how to find out how well your gut is absorbing vitamin D3, is by doing this blood test. It is now generally accepted that a good range of the 25-hydroxy vitamin D level is between 50 and 80 ng/ml.

Also curcumin 500 mg per day is good for cancer prevention. Turmeric | Cancer in general | Cancer Research UK.

Take enough fiber

Make sure you take enough fiber, which does not only reduce colorectal cancer, but also many other cancers. Foods for Cancer Prevention. North Americans are not consuming enough fiber. Vitamin D3 in cancer prevention and therapy: the nutritional issue.

Avoid processed meat

The World Health Organization has determined that processed meat is causing a lot of cancer. They labeled processed meat as a probable carcinogen. Processed meat causes colorectal cancer, pancreatic cancer and prostate cancer.

Moderate amounts of fruit and vegetables

Eat moderate amounts of fruit and vegetables. The claim in the past that fruit and vegetables would protect you from cancer is not as solid as it was thought of in the past. Newer research has shown that a basic intake of fruit and vegetables is needed for essential nutrients, but consuming more than that will NOT protect you from cancer. Fruit and vegetables and cancer risk. This is a case where eating more vegetables or fruit beyond a certain point will not do harm, but it will not protect you further from cancer.

Drink green tea or black tea

Drink green tea or black tea, sweetened with stevia for cancer prevention: Winter Beverages for Cancer Prevention. Green tea contains polyphenols and antioxidants. One of the antioxidants is called catechin, which prevents cell damage. The antioxidants help to prevent breast cancer, colorectal cancer and prostate cancer. In addition tea is heart healthy.

Avoid alcohol consumption 

Avoid alcohol consumption as much as possible to prevent cancer: Drinking Alcohol Really Does Raise Your Cancer Risk, Doctors Warn. We were indoctrinated by cardiologists that one glass of wine per day for women and two glasses of wine per day for men would be a prevention against heart attacks. But these relatively small amounts of alcohol do have an effect on causing cancer.  This British study showed that small amounts of alcohol indeed are cardioprotective. In contrast, these amounts and higher alcohol amounts can also cause cancer of the pharynx, larynx (voice box), esophagus, liver, breast, colon and pancreas.

Avoid too much red meat consumption

Beef, lamb and pork probably contribute to causing cancer according to the WHO. Use common sense, and eat more fish, chicken and turkey. Reduce your beef consumption. My grandmother said when I grew up in Germany that beef was a meal reserved for Sunday dinner only. The rest of the days we ate little in the way of meats, but lentils, beans, eggs or fish instead. Ask your grandmother, what she used to cook. Or ask your mother what she ate as a child.

Other lifestyle issues

Quit smoking, if you still do. This is by and large the biggest risk for developing lung cancer, throat cancer, esophageal cancer and pancreatic cancer. Watch your calorie intake: eat smaller meals more often. This way the production of your digestive juices will consume some calories and because you satisfied your hunger for foods, you will not gain weight. This will help prevent obesity and type 2 diabetes, both of which are established risks for developing cancer. Here is a review that shows you, which cancer types are caused by obesity: Obesity and Cancer . With regard to diabetes, there is a strong association with developing liver cancer, pancreas cancer and endometrial cancer (=uterine cancer). There is a lesser risk (only 1.2 to 1.5-fold) to develop colorectal cancer, breast cancer and bladder cancer. Diabetes and Cancer: A consensus report.

Pollution can also be a factor in causing cancer: How air pollution can cause cancer. If you can move to a less polluted city, do so.

Foods That Can Protect You From Cancer

Foods That Can Protect You From Cancer

Conclusion

As shown above there is strong evidence that certain foods can cause cancer. Others, including supplements like curcumin and vitamin D3, can help prevent cancer. If we avoid as many of the known cancer producing foods and eat more of the healthy foods that do not cause cancer, our cancer risk will decline significantly. In addition, if you quit smoking, avoid pollution as much as possible, reduce your alcohol intake and watch your calorie intake to prevent obesity and type 2 diabetes, you will move into the low-risk cancer group. We all need to work on this on an ongoing basis.

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Feb
24
2018

What Causes Premature Aging?

Some people look 10 years older than their stated age, and we often wonder: what causes premature aging? Accelerated or premature aging can have a multitude of underlying causes. I will list a few here:

1. Weakening hormones

Men go through andropause at around the age of 60 to 65 and women go through menopause around the age of 55 to 65. In both males and females it is the sex hormones that are missing around that age. If hormones replacement follows fairly quickly with bioidentical hormones, this will not affect the visual appearance that much. In contrast, if bioidentical hormones are not the therapeutic choice for  hormone replacement, but synthetic ones, the hormones are not in balance, as synthetic hormones do not restore the hormonal balance. Nothing is gained, as the person will still age prematurely.

Synthetic versus bioidentical hormone replacement

In addition the synthetic hormones will cause heart attacks, strokes, clots, and cancer. Prescriptions for synthetic hormones are often the cause that the aging patient population gets these serious complications. Frequently physicians insist on using synthetic hormones from a “reputable” drug company to replace missing hormones. The reason this does not work is that a male has testosterone receptors. They need to be stimulated by bioidentical testosterone to restore all of his missing functions. Also, the same is true in menopausal females who need stimulation of their estrogen receptors and progesterone receptors. Consequently, only bioidentical hormones will return a postmenopausal woman back to normal. There is a perfect fit between the bioidentical replacement hormones and her hormone receptors. Using synthetic hormones is like trying to unlock a door with a key that does not have a perfect fit: you damage the lock!

2. Missing human growth hormone (HGH) and thyroid hormones

These hormones have a special place in aging.

Human growth hormone deficiency

First, HGH production is running out in many people at age 60. A person with HGH deficiency will have lower muscle mass and strength. Other symptoms are dry and thin skin, particularly at the back of the hands. Men are balding, and they loose interest in sex. There are difficulties concentrating and they may have “senior moments”, which are memory lapses. Often they are prone to depression and anxiety. A blood test will frequently show elevated triglycerides. A blood test (IGF-1) and a urine test exist which make it possible to look for HGH metabolites to assess whether a 40, 50 or 60 year-old person is producing enough HGH. Many may need replacement of HGH. This is administered by injection through a tiny needle into the skin, similar to a diabetic injecting insulin. This will bring back what was missing due to HGH deficiency.

Thyroid hormone deficiency

Thyroid hormones (T3 and T4) are other important factors that could make you look older prematurely. Your hair is getting thinner; your skin turns dry and pale. The nails may be getting brittle. When the outside half of the eyebrows is very thin or missing, this can be a sign of hypothyroidism. In a similar vein the skin in the face may be puffed up due to swelling of the layers under the skin (myxedema). It is important to diagnose hypothyroidism, which is common in the aging population. The physician needs to order a blood tests (TSH, T3 and T4). If TSH is above the upper limit, your physician needs to replace both T3 and T4 by tablets (I prefer Armour as the T3 and T4 is balanced).

3. Smoking

The lining of the airways absorb cigarette smoke. The chemicals circulate around in the blood and lead to aging of the skin. Chronic cigarette smoke exposure also melts away the subcutaneous tissue. The end result is a haggard look. The natural glow disappears from the skin and because of carbon monoxide binding to hemoglobin the skin color looks more greyish. In addition the blood vessels are narrowing or clogging. This means that the body cannot absorb nutrients as well, and cells are starving. There is only one remedy for this: quit smoking!

4. Overexposure to ultraviolet light

The radiation of UV light can penetrate deep into and under the skin. This makes the subcutaneous fat melt away. The largest UV exposure is in the facial area. As a result we see aging there. The end result is a sagging appearance of the face. This link has an image of a woman before and after a non-surgical facelift with stem cells and fatty tissue: Stem Cell Treatments That Are Currently Available – Medical Articles by Dr. Ray

In a surgical procedure the physician harvests mesenchymal stem cells from fatty tissue by liposuction. A cell separator separates the mesenchymal stem cells, the connective tissue and the fat cells. The connective tissue is discarded. Mesenchymal stem cells and fat cells are mixed and injected into the thinned subcutaneous fatty tissue until the person’s younger facial contour is back to normal. Typically this will last for 10 years or more.

5. Drugs and alcohol abuse

Both can lead to malnutrition with weight loss and loss of subcutaneous fatty tissue, which causes sagging breasts in women. In men “beer tits” are common. The reason for this is estrogen accumulation, as alcohol interferes with the elimination of estrogen in the liver. Alcohol is a general cell poison. It causes all of the cells to age prematurely. The more alcohol you drink, the faster you age. The skin develops wrinkles, loss of elasticity and collagen, redness and puffiness. In other words chronic alcohol abuse ages you prematurely. The only remedy for this is to quit drinking. Some of your skin vitality may come back. Our body has an amazing capability to heal itself!

6. Medical illnesses

Many medical illnesses like diabetes, mental illness (depression and schizophrenia), multiple sclerosis, inflammatory bowel disease; cancer and others make you look a lot older very fast.

I will briefly explain the reasons for this.

  • Diabetes

With diabetes type 2 the pancreas releases too much insulin after a meal with starches and sugar; think about a sweet muffin or a toast with jam. The extra insulin causes inflammation. This stimulates enzymes that break down elastin and collagen, leading to wrinkles and sagging skin.

  • Mental illness like depression and schizophrenia

We know from studies that depression leads to shortening of telomeres. This in turn causes cell death in the most rapidly dividing cells like in the skin and hair follicles. The end result is prematurely aged hair and skin. Schizophrenia also leads to premature shortening of the telomeres, which causes premature aging, mitochondrial dysfunction, inflammation and oxidative stress. The end result is that the person looks older than what their chronological age is.

  • Multiple sclerosis

It is sometimes difficult to discern in patients with MS what is normal aging and what is aging from the disease. This link gives some background on this. Many MS patients are anxious, and anxiety and stress by itself also leads to premature aging.

  • Inflammatory bowel disease

The chronic inflammation of either ulcerative colitis or Crohn’s disease can lead to premature aging. High doses of vitamin D3 and molecularly distilled fish oil can be useful to help treat the inflammation. Probiotics are also important to restore the bowel flora.

  • Cancer

Cancer leads to cachexia (excessive weight loss). There is also excessive inflammation, which leads to accelerated aging. The inflammation causes increased oxidative stress. This leads to tissue damage and DNA damage, which makes all cells more vulnerable to develop other cancers. Oxidative stress can substantially accelerate telomere shortening. As a result skin can become saggy, wrinkles develop and the person looks prematurely aged.

7. A chronic lack of physical activity

People who never exercise tend to get overweight and eventually obese. This leads to premature aging. Exercise would elongate telomeres, but inactivity shortens them. Obesity leads to increased oxidative stress and to DNA damage. Obesity also shortens telomeres. All of this leads to premature aging.

What Causes Premature Aging?

What Causes Premature Aging?

Conclusion

These are only a few examples of causes of accelerated aging. The key is to stick to a healthy, balanced diet (like the Mediterranean diet) and exercise regularly. Stop smoking (if you do), don’t take street drugs, and make sure you get enough sleep. Getting enough sleep helps your hormones regenerate overnight. The sympathetic overdrive from your daily activities is counterbalanced by the parasympathetic activities during sleep that causes relaxation. For hormone replacement you may have to see an anti-aging physician, a naturopath or integrative medicine physician. This may be your only chance to address any hormonal deficiencies. Conventional medicine does a very poor job of HRT (hormone replacement therapy) with synthetic hormones. Conventional practitioners want to treat you with synthetic hormones that will make you sick. Hormones for replacement have to be bioidentical! This way you will live 10 to 15 years longer, look younger and stay healthy.

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Feb
03
2018

Drugs Are Not An Escape

We have a drug epidemic, but drugs are not an escape. Along with this epidemic there have been thousands of lethal overdoses. I like to review why so many people use street drugs or prescription pain pills. It started years ago with heroin injections had become more popular. But then heroin was getting a bad name, it became illegal, and prescription pain pills replaced heroin. Percocet, OxyContin and morphine prescriptions took off. Together with it the number of people with addiction increased drastically. The latest fashion craze is Fentanyl.  Fentanyl works faster than morphine, but also wears off faster. One of the deadly side effects is respiratory depression. This  means that a person cannot breathe and as a result will die. This is what is happening right now and what creates the news headlines.

Pain receptors

There are pain receptors all over the body, in muscles, organs and the skin. They are called nociceptors. Many medical conditions lead to pain in various parts of the body. For instance, with end stage degenerative arthritis bone rubs on bone. This causes a lot of pain in joints like the knees or the hips. Physicians often prescribe narcotics like OxyContin to control the pain. It may help for some time. But after a few weeks patients complain that the strength of OxyContin has worn off. The same dosage that gave them relief from the pain initially just does not give them relief any more. This observation is crucial. It is exactly what people who use OxyContin as illicit street drug found as well. The drug wears off, because the opioid receptors are getting weaker.

Pain receptor resistance

Nociceptors or opioid receptors are pain receptors. These receptors report pain to the body, and they have connections through the spinal cord to the brain. When an opioid is interacting with the pain receptor it inhibits acute pain to a large extent. But when the pain becomes chronic, the pain receptor is not working as well. More and more of the pain medication is necessary to achieve pain relief.  Eventually the opioid medication is not working to relieve pain any more. The name for this phenomenon is “pain receptor resistance”. Scientific work behind why pain receptors get lazy in responding to opioids is still ongoing. In the meantime it simply is an observation. This is the reason why drug addicts are tending to increase the dosage of OxyContin or of Fentanyl. The toxic threshold of Fentanyl that is exceeded in the process is the reason for the deaths.

Insulin resistance

You may have heard of insulin resistance in diabetics. This is a very similar problem. With insulin resistance the diabetic no longer has a 100% response to insulin. This means that blood sugar is not going through cell membranes effectively as it should when the insulin receptor is working. The blood sugar values stay high and make the diabetes worse.

With pain receptor resistance the opioid is not giving the relief from pain it used to give. No wonder that the patient is feeling frustrated that the pain medication is no longer working properly.

Therapeutic index

The layperson does not normally know that there is a dosage for any drug where it becomes toxic. There is also a lower dosage where the drug is becoming effective. The difference between the two dosages is the “therapeutic window” or the “therapeutic index”.

Morphine has a therapeutic index of 70:1. Compare that to alcohol with a therapeutic index of only 10:1. Fentanyl has a therapeutic index of 300:1.

The danger of Fentanyl

One would think that Fentanyl should be safer than morphine, because the therapeutic index is larger. But the onset of Fentanyl is much faster than that of morphine and by the time drug users take Fentanyl they often are desperate for the drug to take their pain away and they overdose, which causes respiratory depression. If they are not intubated by an anesthetist and connected to artificial respiration, they die very quickly. Janssen Pharmaceutica first developed Fentanyl in 1959. Fentanyl was strictly part of the pre-anesthetic medicine for patients before going into surgery requiring a general anesthetic. The anesthetist was right there and would intubate the patient. That’s why we never heard of deaths from Fentanyl in the past.

If a person gets no pain relief from any opioid because of receptor resistance, the tendency is to increase the dosage. But this is what pushes the person into toxic ranges and this is what causes death from inadvertently suppressing the ability to breathe. People can get into trouble with alcohol overdoses, but the ordinary person usually knows how to handle alcohol. Fentanyl is a lot different due to the fact that respiratory depression (not being able to breathe) is one of the early symptoms that hits you suddenly.

What drugs do to your brain

Dr. Daniel Amen, a psychiatrist and brain researcher has used SPECT brain scans to produce images of different clinical conditions. This link shows the effect of a stroke, of Alzheimer’s disease and of drug abuse on the brain. Dr. Amen says that a brain can be rehabilitated. He has other SPECT images showing the images of an addicted brain and that of a rehabilitated brain. Spect scans are expensive.  But they may be worth it, to impress a drug addict to stop the drugs and get rehabilitated.

Big Pharma and opioid drugs

In 1995 the FDA approved the use of OxyContin for chronic pain. Perdue Pharma, the drug company that had developed this opioid convinced the FDA that OxyContin stayed in the blood for 12 hours and they claimed that by being active longer than other opioids this would lead to better pain control and less addiction. It turns out that this was a slick sales pitch, however it was not true. Pain receptor resistance is as much a problem with OxyContin as with any other opioid. And the drug is as addictive as all the others. But the problem is that the FDA had approved OxyContin. What’s more, Purdue Pharma sent aggressive drug representatives to all the practicing physicians misleading them as well as the FDA that OxyContin would not be as addictive as other opioids.

Penalty for misrepresentation of OxyContin

In 2007 Purdue Pharma had to pay a fine of 634 million $ for misrepresenting the addiction potential of OxyContin. But the drug company was allowed to continue to market OxyContin. Since 2015 Purdue Pharma has been cashing in 2.4 billion $ annually from the sales of opioids including OxyContin. In the meantime Fentanyl, despite its danger of suppressing the ability to breathe, has taken off with regard to sales. Fentanyl also has taken over in terms of causing deaths across the US and other countries.

Alternative treatment of pain

According to Ref. 1 chances are that 70% of patients with back pain will get better with a few visits to an acupuncturist. In 1972 Dr. Ulett’s laboratory at the University of Missouri succeeded in getting the first NIH research grant for the study of acupuncture in the US. During these studies they found remarkable facts, the most important perhaps that electrical stimulation of acupuncture needles resulted in a doubling of the effectiveness of traditional Chinese acupuncture. After extensive research Dr. Ulett stated: ”The ancient practice of traditional Chinese acupuncture is now obsolete” (Ref.1). in the meantime the more effective electro-acupuncture has replaced acupuncture needles with the use of electrical skin pads.”

Other applications for electroacupuncture

Beside pain relief many other applications exist for electro-acupuncture. Addiction medicine makes use of electro-acupuncture in weaning people from morphine or heroine etc. It is effective to treat psychiatric illness, particularly depression. It is useful in relieving nausea and vomiting due to chemotherapy with cancer treatments or associated with pregnancy without affecting the pregnancy.

Prolotherapy

Prolotherapy has been successful for the treatment of back and neck pain, for arthritic pain and pain from chronic muscle spasm. When prolotherapy is done by itself 12.5% Dextrose is injected into the area of injury. Dr. Fields said that the reason it works is that there is activation of local stem cells in the injured area in the area of the Dextrose injection site. These stem cells will do the healing (details explained in an interview with Dr. Reeves). Further improvement of this technique and better results are possible by injecting a small amount of platelet rich plasma (PRP) very focally to an area of ligament rupture. PRP is obtained by centrifuging blood from the patient’s vein. The red blood cells are not necessary, but the platelet fraction and some of the plasma are part of the the PRP preparation.

It is often striking how much pain control occurs after only one or two prolotherapy treatments.

Stem cell therapy with PRP and low-dose laser therapy

This is a more direct way to get stem cells where the doctor wants them to do their work. Stem cell therapy with PRP and low-dose laser activation is the latest in terms of controlling pain. At the 22nd Annual Anti-Aging Conference in Las Vegas (Dec.10 to 14, 2014) Dr. Purita gave an overview of this method of pain control. He discussed the importance of the proper harvesting of PRP. He explained that apart from white blood cells (WBC) and platelets an important component of PRP are very small embryonic like stem cells (VSELs). They are visible through the microscope. The missing link has been the observation that white blood cells produce inflammatory substances, which have been detrimental in stem cell injections with PRP in the past. There was a poor survival rate of stem cells.

Low dose laser activation of stem cells and PRP

Photo-activation of the PRP before injection leads to anti-inflammatory behavior of the WBC in PRP. Dr. Purita calls this “light activated PRP”, which leads to the best results with stem cell/PRP injections.

Soft laser stimulation with red, green and blue soft lasers have also been effective to improve tissue healing significantly when stem cells and PRP are used together with light activation. The main sources for good stem cells are the fat tissue (from the “love handles”) and the bone marrow (obtained from pelvic bone). The stem cells mesenchymal stem cells (from fatty tissue) and bone marrow stem cells. The mix of all of this can mend osteoarthritic joints, degenerative disc of the spine, in short all musculoskeletal injuries that may be painful. The hallmark of healing with stem cells is that chronic pain disappears.

Curative treatment versus symptomatic treatment

It is one thing to treat a patient for pain symptomatically by prescribing OxyContin or other opioids. It is a completely other thing when the physician cures the pain by one of these alternative methods. Let us assume that a patient has a fall of a few step from a ladder and sustains a contusion of the lower back. This can be painful and may require a few pain pills. But if it does not improve within one week and diagnostic tests show that there is no fracture, electroacupuncture may be the solution to treat the pain rather than the use of an opioid. If this does not help, consider the combination stem cell/PRP/low-dose laser therapy. Chances are better than 80% that this will help. The patient will no longer suffer of pain. With healing life can go on: no pain pills. No addiction. No death.

Drugs Are Not An Escape

Drugs Are Not An Escape

Conclusion

Conventional medicine treats pain symptomatically instead of treating the cause. It gets the physician to prescribe opioids, which can be the beginning of a series of tragic events. It can lead to drug addiction, dose acceleration, toxic effects of opioids including possible death through asphyxiation from no longer being able to breathe.

Stem cell therapy

The physician who concentrates on treating causes will use alternative methods to treat pain. The most effective of these methods is stem cell therapy. It is a mixture of adipose mesenchymal stem cells with bone marrow stem cells that are part of the therapy. The addition of platelet rich plasma is another part of the mix, and the final step is activation of stem cells with low-dose laser therapy. The cell mix is injected in the critical area. The end result is that the patient’s pain disappears, and it leads to a cure. The only situation where short-term opioids are justifiable is following surgical procedures. But even in these cases the narcotics should only be necessary for a few days to avoid serious side effects.

Reference 1: George A. Ulett, M.D., Ph.D. and SongPing Han, B.M., Ph.D.: “The Biology of Acupuncture”, copyright 2002, Warren H. Green Inc., Saint Louis, Missouri, 63132 USA

More info about electroacupuncture: http://www.askdrray.com/electro-acupuncture-twice-as-effective-as-conventional-acupuncture/

More about prolotherapy stem cell therapy: http://www.askdrray.com/prolotherapy-and-stem-cell-therapy/

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Dec
23
2017

Birth Control Pill Increases The Risk Of Breast Cancer

A recent study showed that the birth control pill increases the risk of breast cancer. This publication did research on 1.8 million of women of Denmark who took various forms of contemporary birth control pills (BCP). They were under the age of 50 and the observation of the participants continued for about 11 years.

Risks for breast cancer

When a woman took the BCP for less than one year, the risk of developing breast cancer was 9% higher compared to controls. But this rate increased even more to 38% after the use of the BCP for over 10 years. Women who had used progestin only intrauterine devices had a risk of 21% to develop breast cancer. It did not make a difference whether the BCP was a mix of estrogen and progestin or progestin. Researchers expressed the risk in the following fashion:

  • Less than one-year exposure to BCP: a 1.09-fold risk to develop breast cancer
  • Over 10-years use of BCP: a 1.38% risk to develop breast cancer
  • IUD with progestin in uterus: a 1.21% risk to develop breast cancer

Strokes and Heart attacks from the BCP

At the 86th Annual Meeting of the Endocrine Society in New Orleans/Louisiana a Canadian delegation presented this data. They had done a meta-analysis of 14 trials regarding side effects of the birth control pill (BCP). These women had taken the BCP on a prolonged basis (Ref. 1). The researchers monitored the risk of heart attacks and strokes. They found an association with the prolonged use of the low dose estrogen BCP. Researchers examined all of the studies between 1980 and October of 2002. 14 independent studies qualified for the meta-analysis.

Metaanalysis of BCP caused heart attacks and strokes

The strength of such a meta-analysis lies in the pooling of data and the fact that the data comes from a much larger patient population, which generally makes the results more reliable. Dr. J. Baillargeon from the Centre Hospitalier Universitaire in Sherbrooke, Quebec/Canada, stated that they found a

  • 85-fold risk for developing heart attacks with long-term use of the BCP and at the same time there was a risk of
  • 54-fold of hemorrhagic strokes with long-term use of the low-dose BCP.

It is important that women who contemplate going on the BCP know not only about the dangers of developing breast cancer, but also about the dangers of heart attacks and hemorrhagic strokes.

Lessons learnt from the Women’s Health Initiative

The Women’s Health Initiative in 2002 showed that women who were on Premarin and progestin for hormone replacement in menopause came down with breast cancer, heart attacks, stroke, and thromboembolic events. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127562/

They were using the synthetic hormones, namely conjugated equine estrogen and medroxyprogesterone acetate. The reason these women had to suffer these side effects was because their physicians insisted on using “pure hormones that a drug company had manufactured”. But these synthetic hormones were not pure hormones; they were hormones adulterated with side chains so that pharmaceutical companies could patent them.

Misfit of synthetic hormones with hormone receptors

These side chains made the synthetic hormones not fit the body’s hormone receptors. And this is the reason why the synthetic hormones created chaos in the body with breast cancer, strokes and heart attacks. In essence the mix of conjugated equine estrogen and the medroxyprogesterone were functioning like estrogens. So, there was an overdose of estrogenic hormones when taking these hormones and this use resulted in the development of breast cancer, heart attacks and strokes. The BCP is very similar to these hormones that are in the medication for hormone replacement therapy in menopause, but the hormone dosage in the BCP is much lower.

Other high-risk settings for women taking the BCP

There are other higher risk subpopulations of women who should avoid the BCP:

  • Had 1st degree relative with breast cancer on one breast :5-fold relative risk ; there is a genetic reason for breast cancer here
  • 1st degree relative with breast cancer on both breasts : 9.5-fold relative risk ; genetic risk more obvious.
  • No relative, but patient had history of breast cancer : 4-fold relative risk ;
  • First child born later than 30 years of age : 1.9-fold relative risk ; in comparison with a woman who has her first child prior to age 20
  • If woman consumes 3 oz. of alcohol per day : 2-fold risk; in comparison with woman not using alcohol or BCP
  • Prior radiation for Hodgkin’s disease (age 10 to 19) : 10- to 75-fold risk; radiation exposure during time of breast development leads to an enormous risk ratio about 15 years later

Mechanism of the BCP

The BCP or OC (oral contraception) utilizes the fact that ovulation (=release of a fertile egg) requires a complex interaction between hormones to occur. The gonadotropin hormones LH and FSH from the pituitary gland must stimulate the ovaries. The right mixture of estrogen and progesterone from the ovaries achieves this. Without that proper hormonal interaction ovulation will not take place leading to an infertile cycle. With contraception scientists were able to suppress ovulation for as long as patients are taking the birth control pill regularly. By giving a small amount of estrogen and progesterone like substance (called “progestin”) in the oral contraceptive form (the birth control pill) ovulation stops, the lining of the uterine cavity becomes stable through estrogen, and the mucous plug in the cervical canal thickens, making it much more difficult for sperm to enter.

Estrogen dominance from the BCP

The Women’s Health Initiative has taught physicians a tough lesson: you cannot mess with nature’s hormones or else you create a risk of strokes (41%), heart attacks (29% more), blood clots (twice as many), breast cancer (26% more), colorectal cancer (37% more) and the patient will have a higher risk for Alzheimer’s disease (76% more often). This was a trial involving over 16,000 postmenopausal women.

Although the hormones used in these women were slightly different in concentration, structurally they were very similar to the ones used for birth control purposes. What nature seems to tell us is that you cannot mess with hormone receptors, or you set up the body for one of the diseases mentioned.

Hormonal disruption

The truth is that the combination of  synthetic estrogen-like and progesterone-like substances  in the BCP are not bio-identical hormones. They suppress ovulation, which means they are creating progesterone deficiency in the woman who takes these synthetic hormones. The end result is that physicians create estrogen dominance in these women, which according to Dr. Lee is the reason for the above listed complications (Ref.2).

It makes more sense to use less invasive alternatives for birth control methods instead of the BCP. A well-fitted IUD (inserted by a gynecologist) is a good alternative. This will not create havoc with the woman’s hormones and will not create infertility after contraception is no longer needed. Bio-identical progesterone replacement using creams is being used to rebalance the original hormones when the BCP is discontinued.

Birth Control Pill Increases The Risk Of Breast Cancer

Birth Control Pill Increases The Risk Of Breast Cancer

Conclusion

The birth control pill (BCP) is a popular form of contraception. But there are significant risks of breast cancer, heart attacks and strokes associated with its use. According to the previous literature the risk of complications associated with the BCP was between 1.3- and 1.6-fold. The present study with smaller concentrations of hormones in the more modern BCP still showed a risk of 1.38-fold regarding breast cancer. It did not mention heart attacks and strokes as additional risk factors. The Danish study was supported by a grant from the Novo Nordisk Foundation. Novo Nordisk is a major producer of BCP’s in Europe and in the world. It would be in their interest to minimize the risks associated with the BCP. Any woman using the BCP should use it only as long as she really needs it. Ultimately she would be better advised to use alternatives like IUD’s and condoms.

References

  1. http://www.askdrray.com/birth-control-pill-increases-strokes-and-heart-attacks/
  2. John R. Lee, David Zava and Virginia Hopkins: “What your doctor may not tell you about breast cancer – How hormone balance can help save your life”, Wellness Central, Hachette Book Group USA, 2005. Page 360 to 374 explains xenohormones.
Dec
16
2017

Mouth Flora And Your Health

You may not be aware that there is a connection between mouth flora and your health. But a recent publication provided proof that certain bacteria can cause esophageal cancer.

Esophageal cancer from certain bacteria

In a 2017 publication a study of mouth flora from 122,000 people showed an association to two types of esophagus cancer. The finding was that the periodontal pathogen Tannerella forsythia had as association with esophageal adenocarcinoma. This cancer is originating from the glandular tissue of the esophagus. In contrast, the bacterium Porphyromonas gingivalis caused another histological type of esophagus cancer, namely esophageal squamous cell carcinoma. This cancer originates from the inner lining of the esophagus. In addition, two mouth bacteria showed a relationship with reduced risk of causing esophageal adenocarcinoma. These two common mouth bacteria were the Neisseria species and the species Streptococcus pneumoniae.

Clinical example of a patient with esophageal cancer

To illustrate this with a clinical case description, here is an example from another publication. This is regarding a man who suffered from esophagus cancer. Initially doctors were puzzled about his diagnosis. He was a 53-year old patient with chronic alcoholic liver disease. He had an increased white blood cell count. A blood culture isolated Parvimonas micra, which is a pathogen normally only living in the mouth flora. A gastroscopy as part of the work-up showed an invasive squamous cell carcinoma of the esophagus. It had almost completely blocked the passage to the stomach. The pathological bacterium had accessed the blood circulation via the tumor mass in the lower esophagus. In the past physicians did not know about these associations.

Brush your teeth and floss every day

Brushing your teeth and flossing everyday controls the bacteria in your mouth. It prevents leakage of bacteria into your blood affecting your heart valves. Studies have shown that this also prevents heart attacks.

The literature on this is clear: chronic gingivitis has a link with bacteria in the mouth. They grow on the gums and can spread into your blood. They can then colonize in your heart valves and even in the lining of the arteries. This is particularly so in cases where there is already hardening of the arteries (arterial plaque). This can lead to heart valve disease like mitral valve disease. If this process occurs in coronary arteries, it can lead to heart attacks.This reminds you that there is a connection between mouth flora and your health.

Mouth wash

Many people feel they have “bad breath” and they need a mouthwash product. This is good marketing for companies that produce mouthwash. However, the truth is you need to be diligent about appointments with a dental hygienist, brush your teeth regularly and floss your teeth. If you suffer of constipation, increase your fiber intake and consider colonics. If you still think you have bad breath, use a natural mint product (read the ingredients). Why do I not like mouthwashes? They kill your mouth bacteria that are naturally there; this can disbalance the rest of your gut bacteria as you swallow part of the mouth flora when you eat or drink fluids. If you still want to use a mouthwash, use one without alcohol and without any carcinogens such as parabens. Also read this 2009 news item. It is as valid as it was then.

Chronic gingivitis and heart disease

It was not until about the mid 1990’s when it became apparent that gum infections and severe tooth decay could cause inflammation in the blood measurable by using the CRP marker (C-reactive protein). Dr. Joseph Muhlestein at the University of Utah demonstrated in 1996 that chronic gum infection could cause a heart attack. He isolated the bacterium Chlamydia pneumoniae in 79% of patients undergoing coronary bypass surgery, while samples from heart transplant patients isolated this bacterium in only about 5%. The new thinking was that bugs that multiply in diseased gums could migrate into the blood and cause platelets from the blood to clump together and block coronary arteries causing heart attacks. Also, restenosis after percutaneous coronary intervention was more likely to occur, if the pathogen count of gum bacteria in the blood was higher.

Infectious causes of endocarditis and heart attacks

Harvard University researchers have confirmed this. In the past physicians did not know that a bad tonsillitis with an aggressive bacterium, Streptococcus viridans, could cause subacute endocarditis, a dangerous infectious disease of the heart valves, which can be responsible for sudden death in younger persons. Neglected cavities in teeth can also harbor this bacterium. Another study in 2009 showed that two particular strains of bacteria in infected gums, Tannerella forsynthesis and Preventella intermedia, showed a connection with an increased risk for heart attacks; but it was more the overall burden of bacteria in the infected gums than the specific bacteria strains that mattered most.

See your dental hygienist regarding your mouth flora and your health

Given this background it is easier to understand that we need to take good care of our teeth and gums, if we want to maintain good health. As a start most people should see their dental hygienist (who usually works in a dentist’s office) twice a year. The dental hygienist will probe the depth of gingival pockets with a periodontal probe. A normal depth measures up to and including 3 mm. Deeper pockets than that usually indicate that the patient did not floss the teeth regularly. One needs to floss at least once per day, better twice per day, and it should not bleed after flossing (initially when a person flosses for the first time the gums tend to bleed a bit).

What the dental hygienist does

The hygienist will do scaling of plaques on the tooth enamel. If the hygienist detects any cavity, he or she will bring it to the attention of the dentist. At the end of the scaling procedure the hygienist will apply fluoride, which puts a coating on the tooth surfaces to prevent tooth decay.

When deeper pockets (6 mm or more) are detected a trial of sub-gingival root brushings has shown to have a very beneficial result within only 14 days.

Periodontal pockets were improved and bacterial counts of periodontal infections also showed improvement.

Mouth flora in alcoholics

This 2016 study from Poland examined the mouth flora of 25 alcoholics. They were compared to the mouth flora of 25 patients from a periodontology clinic.

There were significant differences between the two groups. The alcoholic group had higher bacterial counts of these three strains: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Treponema denticola. There was no difference in bacterial counts between those who drank only little alcohol compared to those who drank lots. The bacterial concentration in the sub-gingival flora was the same. Patients with severe periodontal disease had the same distribution of the three strains of bacteria as chronic alcoholics. However, the concentration of bacteria in alcoholics was much higher. This fact may explain why chronic alcoholics are very sensitive to infections. Alcohol inhibits the immune system, but stimulates the growth of sub-gingival bacteria, which find their way into the system and in serious cases can kill the patient.

Mouth Flora And Your Health

Mouth Flora And Your Health

Conclusion

It is now a well-established fact that mouth bacteria play an important role in our health. Some of the healthy bacteria find their way into the gut providing the foundation of a healthy gut flora. But as described above there are also pathological bacteria that can multiply in our mouth cavity and our gums. This happens particularly in people who do not floss and who develop gingivitis and periodontitis. Tannerella forsythia was associated with esophageal adenocarcinoma. In contrast, the bacterium Porphyromonas gingivalis caused esophageal squamous cell carcinoma. Streptococcus viridans could cause subacute endocarditis, a dangerous infectious disease of the heart valves. Tannerella forsynthesis and Preventella intermedia showed an association with an increased risk for heart attacks.

Bacteria associated with alcoholism

Here are three mouth bacteria associated with alcohol consumption and with chronic periodontitis. They are Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Treponema denticola. Don’t let the strange sounding names of mouth bacteria confuse you. Fact is that these bacteria, when entered into the blood vessels and the rest of the body, will play havoc with your health. Keep brushing your teeth at least twice per day and floss your teeth conscientiously once or twice per day as well. This will improve your mouth flora and your health.

More info: http://www.askdrray.com/flossing-and-brushing-saves-your-heart/

Nov
11
2017

Avoid High Temperature Cooking

In recent years publications have shown that you need to avoid high temperature cooking. This will prevent diseases, and this will also prevent premature aging. Cooking at high temperatures creates carcinogens and advanced glycemic end products (AGE’s). Both substances are harmful to our health. Carcinogens are mutagens that attack the DNA of your cells which increases a risk of developing cancer. AGE’s crosslink proteins like antibodies, hormones, enzymes, collagen, neurotransmitters and hemoglobin. When crosslinking like this has occurred, cells are not functioning optimally.

In the case of diabetes the hemoglobin, which is expressed as percentage of glycated hemoglobin, is rising. This leads to damage of hemoglobin by AGE’s. Above a certain normal value complications of diabetes occur, like blindness or amputations of limbs because of circulatory problems. Diabetics also can get excruciating pains from damage to nerves (neuropathies) and heart attacks. In the last few years it has become evident that the old “normal” glycated hemoglobin values recommended to patients were too high. This was the reason why complications still occurred when the patients’ hemoglobin A1C values were within the normal range.

New hemoglobin A1C ranges

At the 22nd Annual World Congress on Anti-Aging Medicine In Las Vegas (Dec. 10-14, 2014) Dr. Piliszek stated that the normal range for hemoglobin A1C is skewed in the medical literature. It should be: 3.8% to 4.9%. This is very important to know for diabetics and any caregiver who looks after diabetic patients. If you are satisfied with a hemoglobin A1C of 6.0 as still being “normal”, the diabetic patient has the risk of dying prematurely of a heart attack or a stroke. According to the new guidelines even a patient whose hemoglobin A1C is 5.5 has diabetes with the new guidelines and needs to be treated aggressively to prevent complications that occur due to diabetes. Conventional guidelines would have considered this patient to be normal. With these new guidelines there won’t be complications as long as the hemoglobin A1C stays in this range.

In a way diabetes is a special case of AGE’s accumulation leading to glycosylated hemoglobin. The hemoglobin A1C value measurement indicates how advanced the AGE’s accumulation is.

What can we do to lower our exposure to AGE’s?

Here is a list of more than 500 common foods. Keep in mind that less than about 700-kilo units/serving is a low glycation product, 700 to 5000 is a medium glycation product and above 5000 would be a high glycation product.

You can tell by comparing methods of preparing various meats how different the glycation product is. You want to avoid broiling, also you will want to poach eggs at medium heat or panfry foods at low heat to keep the glycation product of our food in the low to medium range.

Is preparing food in a microwave oven safe?

We have been indoctrinated that microwave cooking would be gentle and harmless to the food. Newer research has shown that this is not the case! Microwaves produce heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAHs). This is in addition to advanced glycation end products (AGEs), known as glycotoxins. All of them can damage your cells and can cause cancer. There were many investigations of microwave cooking in Russia and Switzerland that describe the problems.

The result of these studies was that microwaving food produced noxious substances that were carcinogenic, contained free radicals and changed blood composition in the volunteers ingesting microwaved foods. There was a leukocytosis (too many white blood cells); decreased immune cells (lymphocytes) and increased cholesterol levels just from consuming microwaved foods. The researchers concluded that microwaved food contained noxious components to which the body reacted. For years the microwave oven industry and various government agencies in Europe and North America have refuted this kind of information. Nevertheless, many people started to abandon their microwave oven based on this newer research.

Other cooking techniques causing AGE’s

Overcooking foods can also cause massive damage to the genes. Women exposed to AGE’s are at a higher risk of developing breast cancer. Their outlook is much worse than for women without exposure to AGE’s.

High temperature cooking causes inflammation, which in turn stimulates glycation of the body’s proteins. As I mentioned before, broiling, baking, grilling or panfrying at high heat will do exactly that. But broiling, roasting, frying and searing also generate AGE’s. Barbecuing belongs to the high temperature cooking methods as well. Unfortunately many of these methods are common in restaurant cooking. You are much better off to prepare your own meals at home where you have control over how many AGE’s you generate when you prepare your food.

Avoid high temperature cooking with these methods

If you don’t have a slow cooker, now is a good time to get one. The advantage of this method is that you can prepare dinner at breakfast time. If you choose to cook a stew, put your beef or bison in together with onions and vegetables in the morning, and let it cook at low heat. When you come home for dinner in the evening, you can smell when you open the door that dinner is ready. The meat is soft and tasty.

Alternatively, if you prepare meat or poultry, you may want to cook the meat at low heat in the oven until it is through. You can boil eggs or poach them. Cooking salmon or other fish works well with low- heat cooking in the oven. Alternatively steaming produces very good results.

Supplements, if you can’t avoid high temperature cooking

Fortunately for those who depend on restaurant foods, there are supplements that have shown to reduce AGE’s significantly. I am describing them in the following and what studies have shown that they are effective. Also, by reducing sugar and starchy foods, particularly processed foods, you can significantly reduce AGE’s in your diet.

1. Chlorophyllin

Chlorophyllin has been known for many years to be an anti-carcinogenic and antimutagenic. 100 mg taken with the heaviest meal will protect you to a large extent from AGE’s and carcinogens in food that has been cooked too hot.

2. Indole-3-carbinol

Cruciferous vegetables (cabbage, cauliflower and broccoli) contain the substance indole-3-carbinol. In mouse experiments it was suppressing carcinogens by up to 98%. It prevented DNA damage by carcinogens in rats up to 95%.

The dosage for humans is 200 mg twice per day, and it has no side effects.

3. Carnosine

Carnosine consists of two amino acids, L-histidine and beta-alanine. It has anti-AGE’s effects. Because of the carnosine enzyme, which degrades carnosine, it requires a fairly high dose of 500 mg twice per day to get a meaningful blood level.

Diabetics are most in need of protection from AGE’s. Prolonged elevation of blood sugars leads to glycation end products as sugar interacts with protein in the body. Carnosine interferes with this AGE’s formation.

In the past the dosage was too low(only 50 mg per day); newer studies established that for a sustained blood level you need 500 MG twice per day. 

4. Benfotiamine

This is another supplement that is of value in preventing damage from AGE’s.

The interested reader can follow the link and learn more about it.

5. Pyridoxal-5-phosphate

This is a metabolite of vitamin B6. It is also useful to counter AGE’s. Dr. Sahelian is of the opinion that for most patients supplementation with multiple vitamins (which includes vitamin B6) is sufficient to have protection through pyridoxal-5-phosphate as vitamin B6 gets easily metabolized into it.

Avoid High Temperature Cooking

Avoid High Temperature Cooking

Conclusion

Advanced glycemic end products (AGE’s) and mutagens from overheating the food we eat is a significant problem. Conditions like heart attacks, strokes and many cancers can have their root in this. The key is to reduce AGE’s by eating less sugar and starchy foods. A Mediterranean diet is a balanced diet that will help to reduce AGE’s in your diet. Besides that we need to watch that we do not overuse alcohol. It is important that we avoid eating fast foods and restaurant foods. Broiled food, baked items, as well as grilled or pan-fried foods contain AGE’s due to the high heat exposure during . Even microwaving food can produce AGE’s and mutagens in food.

What to do instead

Instead, we need to use a slow cooker, poach eggs at medium heat or panfry food at low heat to keep the glycation products of our food in the low to medium range. Once you see the black char marks on meats or a heavy, dark brown surface, you know, that the exposure to high heat has been too much. Overcooking food presents a problem for your health. If we cannot avoid this exposure, we can resort to several supplements that offer us some relief from AGE’s. It makes sense to use those, if we cannot avoid eating out, and we should take them with the heaviest meal of the day.

Oct
07
2017

How Much Drinking During Pregnancy Is Safe?

A recent review of the literature asked: how much drinking during pregnancy is safe? To the surprise of the researchers there was no clear answer in the medical literature between 1950 and July 2016. The researchers wanted to know whether 1 or 2 alcoholic drinks in a week would show a negative effect. Or would it affect the fetus and cause fetal alcohol syndrome?

What is fetal alcohol syndrome?

A mother who drinks several drinks of alcohol per day during her pregnancy will inflict serious damage to her baby. The end result is fetal alcohol syndrome (FAS). There is growth deficiency, usually below the 10 percentile in terms of weight, height or both. There is a characteristic facial appearance like small eye openings and a thin upper lip. In addition severe central nervous system damage is another toxic effect of alcohol on the fetal brain. This leads to gait problems, speech and psychological problems.

Fetal alcohol spectrum disorder

When a pregnant woman consumes less alcoholic beverages, there may be less damage to the fetus. This partial damage to the fetus is called “fetal alcohol spectrum disorder”, which resembles the term “autism spectrum disorder”. However, these two conditions are not related.

In a child with fetal alcohol spectrum disorder some features of fetal alcohol syndrome would be present, but not all. A child with fetal alcohol spectrum disorder may be able to lead an independent life as an adult.

Present rules about drinking during pregnancy

The CDC and the FDA say that a pregnant woman should not consume any alcohol during pregnancy. It even includes the weeks before a pregnancy. In addition, it also applies to the male before he fathers a child. It is a fact that sperm and precursors of sperm are very sensitive to alcohol toxicity. A woman’s eggs are also sensitive to alcohol toxicity. There is no place for a romantic dinner with alcohol  and sex later in the evening, that leads to a pregnancy. Romance and a romantic dinner is quite possible without alcohol, if sex that leads to pregnancy is in the plans. If you plan on getting pregnant as a couple you must be responsible, male or female. In view of all of the knowledge it is just not a good idea to subject yourself to alcohol before pregnancy.

New questions about the minimum toxic amount of alcohol

A search of the literature between 1950 and July 2016 has not revealed any convincing data about what one glass of alcohol per day would do during pregnancy. Some researchers will likely want to approach this topic in the near future. There are many women in the US who drink that much during pregnancy, but do not tell their healthcare providers. Researchers would like to conduct a trial where they follow women who consume one glass of alcohol per day during pregnancy. They will want to compare that to a control group with no alcohol intake during the pregnancy. Next would be a thorough investigation of the offspring and about the presence or absence of fetal alcohol spectrum disorder. At the present time there is no such data. We know that some women expose themselves to these smaller amounts of alcohol. But we do not know whether or not there is a serious consequence for this.

New meta-analysis study from Bristol, England in 2016 regarding drinking during pregnancy

The closest study that may answer part of the above questions is a metaanalysis from England. It attempted to shed some light on exposure of smaller amounts of alcohol during pregnancy. They examined several studies where the exposure was up to 32 Grams of alcohol per week during pregnancy. This is called a meta-analysis.

Researchers examined several parameters like stillbirth, gestational length and preterm delivery (less than 37 weeks). They also examined other factors, like a small baby for gestational age, low birth weight (less than 2500 g), and features of FAS.

Findings of the Bristol study

Researchers pooled a total of 288, 512 participants from several studies. The low alcohol consumption group (less than 32 grams per week) had 10% preterm deliveries. 8% of the babies were small for their gestational age. The offspring of pregnant ladies who drank up to 32 grams of alcohol per week were compared to abstainers. The alcohol consuming group had babies that on average weighed 13.49 grams less. Low birth weights (less than 2500 grams) were the same in both groups. A large US study showed a 24% risk of placental abruption in the light-drinking group compared to abstainers. FAS symptoms, conduct disorder or hyperactivity syndrome were the same in any of the pooled studies. The outcome between abstainers and light-drinking mothers was the same. No apparent difference could be found between the children of either group.

Common sense about drinking during pregnancy

At this point it is the safest to go by the recommendation of the CDC and all the official medical societies that recommend to not drinking any alcohol 3 months before a planned pregnancy and during the pregnancy. I consider it common sense that you avoid a known nerve toxin like alcohol during pregnancy. The toxic effect of alcohol in a high enough dosage does horrendous damage, as it is obvious with fetal alcohol syndrome. It stunts the baby’s growth and damages the brain. We have also seen that a lower exposure to alcohol still produces fetal alcohol spectrum disorder. It does not make sense to me to gamble, whether a lower concentration of alcohol may be “safe” to the fetus.

Limits of what research to do

Knowing that alcohol is a toxin to nervous tissue demands that no pregnant woman should drink alcoholic beverages at all. It simply is not safe. I suspect that some researcher who must do research at any cost will one day produce that hypothetical study of one drink of alcohol per day during pregnancy. I think it will show that a significant amount of cases have fetal alcohol spectrum disorder. The conclusion will be that it is safer not to drink alcohol during pregnancy.

How Much Drinking During Pregnancy Is Safe?

How Much Drinking During Pregnancy Is Safe?

Conclusion

Sometimes science is going beyond where it should go. In the study analyzed above several studies were pooled as a metaanalysis. There are limitations in terms of reliability of such studies.

But when it comes to testing what smaller amounts of alcohol do to a pregnancy we need to ask a few questions. Are we as a society really willing to risk future humans just to satisfy our curiosity whether or not drinking during pregnancy would be “safe”? Common sense tells us that alcohol as a known neurotoxic substance will be detrimental to a developing brain in a fetus, even in smaller amounts. Also, it is not clear whether ethics committees throughout the US will allow such a claim or will shut it down in the planning stages before it can ever take off. I would guess that it is more likely that any such plans for a trial of that nature will come under the scrutiny of the medical authorities including the CDC, the FDA and the American Medical Association and be shut down fairly quickly, because of the potential damage that could be inflicted onto the fetus.

It is much safer to carry on with the existing laws and recommendations and avoid all alcohol exposure before and during pregnancy.

Aug
26
2017

Decreased Sperm Counts In Men

What do decreased sperm counts in men tell us about our world? A recent study has shown that over the past 40 years males in many centers that tested for sperm counts have lost 50% of the sperm count that was normal in the 1970’s. The question is, what could have caused this? Nobody has definite answers. But here are the factors that the Mayo Clinic lists for low sperm counts.

Medical causes of decreased sperm counts in men

  • A varicocele: A varicocele is dilatation of veins close to the testicles. It is presumed that this leads to a higher temperature inside the testicles and this causes a lowered sperm count and poor sperm quality.
  • Antisperm antibodies can cause infertility. Due to low sperm counts.
  • Infections in the testicles reduce sperm production. Gonorrhea and HIV infection are some of the common infections.
  • Some men develop retrograde ejaculation. With this the sperm enter the bladder on ejaculation instead of coming out from the tip of the penis. Alpha-blockers, a type of blood pressure medication can do this as a side effect. But there are also various health problems that can cause retrograde ejaculation like diabetes, surgery to the prostate, urethra and bladder. Spinal injuries can be also a cause of retrograde ejaculations. In many cases the sperm production in the testicles is still present and sperm could be sampled from there for artificial insemination.
  • Tumors of the pituitary gland can interfere with hormone production of testosterone and sperm counts will fall or stop. But other pituitary hormones, thyroid hormone and adrenal gland hormones are needed for fertility.
  • Chromosome defects like Klinefelter syndrome and others can be a cause of abnormal development of the male genitals with low or missing sperm production.
  • Celiac disease is a bowel disease that is due to gluten sensitivity. It causes low sperm counts and infertility, which responds to a gluten free diet. Sperm counts normalize with this diet.
  • There are medications that can decrease sperm production like chemotherapy, anabolic steroid use, antifungals and certain antibiotic medications and some ulcer medications.

Lifestyle causes leading to decreased sperm counts in men

Certain lifestyles and occupations can cause a man to have a decreased sperm count.

  • Drinking alcohol excessively can reduce testosterone production, which decreases sperm count.
  • Recreational drug use: steroids to increase muscle mass cause testicular atrophy and decreased sperm count. Cocaine and marihuana also decreases the sperm count.
  • Certain occupations like welding from exposure to heat and truck driving from prolonged sitting have been associated in some studies with infertility. But there are other studies that could not confirm this correlation.
  • Smoking: Men who smoke have lower sperm counts than men who don’t smoke.
  • Excessive weight: Obese men transform some of their testosterone into estrogen through the action of the enzyme aromatase, which is amply present in fat cells. This leads to low testosterone levels and low sperm counts.

Environmental causes of decreased sperm counts in men

The environment in terms of heat production around the scrotum or exposure to chemicals or ionizing radiation can lower sperm counts in men.

  • Heat around the testicles: studies do not all agree, but there is a tendency for low sperm counts when using saunas and hot tubs frequently. Sitting for longer times or using a laptop computer for longer periods can also increase the temperature of a man’s scrotum and lead to a low sperm count.
  • Exposure to heavy metals like lead, mercury and others can be the cause of infertility.
  • Exposure to radiation can reduce sperm production. With high doses of radiation sperm production may cease entirely. With lower radiation exposures sperm counts may be down for several years before they recover to normal.
  • Industrial chemicals: exposure to fumes from certain chemicals can lead to low sperm counts; benzenes, herbicides, pesticides, xylene, toluene, painting materials and organic solvents are on this list.

Recent study about decreased sperm counts in men as an indicator

We have now reviewed the major causes of low sperm counts in men. I like to revisit the recent sperm study I mentioned in the beginning of this blog. It is unlikely that men in North America, Europe and Australia would spontaneously produce less than 50% of the sperm than men 40 years earlier had produced. The next puzzling fact is that the study found normal sperm production in men in Africa, South America and Asia.

This points to epidemiological differences that reduce the sperm count in men in North America, Europe and Australia. In view of the multitude of possible causes it will require a task force that does a comparative study worldwide looking at exposure history, diets, social habits and other factors.

Fertility clinics are thriving because couples want children. With low sperm counts of males there is more infertility than there was in the past. Density gradient centrifugation is a reliable method of enriching sperm counts.

In the past a couple had no problem getting a successful pregnancy when they wanted it. Now couples often have to be assessed in a fertility clinic because of problems with regard to decreased sperm counts in men, which can cause infertility.

Decreased Sperm Counts In Men

Decreased Sperm Counts In Men

Conclusion

A new study has noticed that over the past 40 years many men have developed low sperm counts. This has caused significant problems with fertility among couples. Fertility clinics are busy trying to help these couples. Density gradient centrifugation has become a common technique to enrich sperm samples prior to artificial insemination. It is a puzzle why the recent study has found normal sperm counts in samples of men living in Africa, South America and Asia. In contrast men living in Europe, North America and Australia have 50% lower sperm counts. The reason may be multifactorial. It will require a team of experts to sort out this discrepancy and hopefully find an answer for men in Europe, North America and Australia to bring their sperm counts back to normal.

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