Aug
03
2013

Treat Causes, not Symptoms

Introduction

In this article I describe that physicians should treat causes, not symptoms. When you see a physician about a health problem, he or she generally listens to your symptoms and examines you. This leads to a diagnosis and the treatment of your symptoms. Medicine has been evolving since, anti-aging medicine has become more prominent and comprehensive medical practitioners have started to treat differently. Some examples below best explain the new approach. This is important as many general practitioners continue to treat symptoms and neglect to search for causes.

Big Pharma and the status quo

Big Pharma is trying to keep the medical system in the “status quo” (the way it is), because they make big money by having general practitioners try out different ineffective medications (this way the profits keep on coming in.) One example is the cholesterol story. High cholesterol only causes 50% of heart attacks, but physicians continue to prescribe statins whenever they detect high cholesterol levels to prevent a heart attack. But high cholesterol could be a cause from hypothyroidism (when the thyroid gland does not produce enough thyroid hormone). Diet can also play  a role, if the patient eats too many helpings of fatty meats and drinks alcohol regularly. Just prescribing statins to lower cholesterol is not the answer, treating the cause is!

I am going to describe 5 clinical examples where physicians usually treat symptoms instead of the causes. If you are in a hurry, just read example 3 below (gastritis and duodenal ulcer). After that you can skip forward and read the conclusion, where I will summarize what I think we should learn from this.

Treating Symptoms Not Effective, Find And Eradicate Causes

Treating Symptoms Not Effective, Find And Eradicate Causes

1)  Rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease where autoantibodies attack the joint surfaces. It is a multifaceted disease and typically requires a rheumatologist to order detailsed tests and formulate the treatment. The standard treatment for RA is summarized in this link. Before engaging in these toxic treatments, it is very worthwhile to study this link and see, if any of your food components may have triggered your arthritis. Various agents in the food can contribute to the development of autoantibodies, such as wheat, soy, MSG, even salicylates. An elimination diet approach could pinpoint if there is any food component that may be the cause of your RA.

Hormonal deficiencies in RA patients

Dr.Lichten treated many RA cases and found (Ref.1, p. 85 and 86) that many patients had hormonal deficiencies. He points out in particular that these patients often lack DHEA. DHEA is known to treat immune deficiencies and T cell responses were observed to raise 10-fold after DHEA supplementation; IGF-1 levels (an indirect measure of human growth hormone) increased and muscle mass improved when exercised as well along with DHEA replacement. RA patients responded well to relatively low doses of DHEA (25 mg daily for women and 50 mg daily for males). When other hormone tests are done to look for deficiencies, Dr. Lichten found sometimes thyroid deficiencies requiring hormone supplementation.

Sex hormone deficiencies often present in RA patients

Similarly, when saliva tests are done to look for sex hormone deficiencies, there may be progesterone and/or estrogen deficiency in women and testosterone deficiency in males that needs to be replaced with bioidentical hormones. In RA patients there may be adrenal gland deficiency setting in, which can be diagnosed by a four-point saliva cortisol hormone test. Only these cases of true hormone deficiency will benefit from small doses of cortisol (the original bioidentical human hormone) given four times per day.

Here is a summary of the usual recommendations for home remedies for treating rheumatoid arthritis. Using electro acupuncture can be very useful for controlling chronic pain, but you still need to work out the cause for your particular case of RA.

2) High Blood Pressure

Most cases of high blood pressure (hypertension) are simply there without a particular cause. It used to be called “essential hypertension”, a fancy name meaning “essentially, we do not know the cause”. The doctor will start treatment with drugs to bring high blood pressure down. Before that the doctor is supposed to ask you to make a good effort to change your life style (cutting out additional salt, exercising, weight loss), but this is often glossed over and drugs are used right away. Drugs for hypertension are not harmless; here are some of the side effects.

Medical textbooks unclear about causes of high blood pressure

The medical textbooks are not very clear on what causes high blood pressure. With renal causes (narrowing of a renal artery) a stent can be placed, the cause is treated and the blood pressure normalizes. As indicated, essential hypertension is the name for the majority of other cases of high blood pressure where officially no cause is known. Patients are usually put on life-long antihypertensive medications, often several drugs in combination, to bring the blood pressure down to 120 over 80.

Factors that contribute to high blood pressure

Despite the notion that we do not know the cause of high blood pressure, we do know that a number of factors can contribute to developing high blood pressure: too much salt in the diet, too much nicotine from smoking and too much alcohol consumption.

A lack of nitrates from green vegetables can cause high blood pressure as well. Nitrates are necessary for the body to produce nitric oxide, a powerful messenger that dilates blood vessels lowering blood pressure. It is produced every second by the lining inside the walls of your arteries. Greens and vegetables, particularly beets, provide nitrates for nitric oxide production.

Nitric oxide and omega-3 fatty acids

Nitric oxide, along with omega-3-fatty acid and prostaglandins are important in relaxing the arterial walls, thus lowering high blood pressure. We also know that in diabetes and obesity high blood pressure is very common, because inflammatory substances circulate in the blood, which interfere with the normal production of the blood pressure lowering nitric oxide.

Treating high blood pressure with the conventional drugs will mask the real underlying causes.

The DASH diet

The DASH diet has helped a lot of people to get their blood pressure under control. However, the critical point in that diet is the limitation of the amounts of grains. In my opinion, wheat and grains, starches and sugar are all empty calories and only stimulate your appetite because of the high leptin and gliadin content from wheat and wheat products. According to the cardiologist, Dr. William Davis, cutting these out will cure not only many cases of hypertension, but also diabetes and obesity. Many physicians criticized him, but in my opinion his work is on solid researched ground. If a patient honestly gives lifestyle changes a try, many side effects and deaths from antihypertensive drugs could be avoided.

3) Gastritis and duodenal ulcer

You see your doctor, because lately you regurgitate acidy stomach contents. You may be diagnosed with gastritis and get a prescription for an acid suppressive drug. But before you take proton pump inhibitors (PPI) study the side effects here. The interesting part is that many chronic gastritis cases are associated with a bacterium called H. pylori. Unfortunately, cimetidine, ranitidine and particularly PPI’s treat the acid problem (the symptomatic treatment of acid suppression). But on the longer term the triple therapy encourages H. pylori to grow more, particularly in the stomach. H. pylori undermines the lining of the stomach and the duodenum. This interferes with the protective mucous production, which protects you from gastritis and ulcers.

Breakdown of the mucosal barrier

Dr. Murray explains that the cause of gastritis, gastric ulcer and duodenal ulcer is the breakdown of the mucosal barrier (Ref. 3, p.73-75). The symptomatic treatment of the H. pylori infection with triple therapy (2 antibiotics and a PPI) is the conventional medical treatment, but in many cases it does not cure H. pylori. Some patients develop diarrhea from a Clostridium difficile super infection as a result of the antibiotics from the triple therapy requiring even more expensive antibiotics for that condition. This only happened, because the physician treated the patients’ symptoms instead of the cause. The cause of gastritis and duodenal ulcers is a weakening of the lining in the stomach and the duodenum resulting in a breakdown of the mucous barrier.

Too much wheat consumption can be a cause

In some people dietary habits play a role, like too much cereal and wheat consumption with too little alkaline vegetables in the meals to neutralize the acid formation (see Ref. 2 for more details). However, when a simple licorice compound (DGL, which stands for deglycyrrhizinated licorice) is given, the symptoms from gastritis, acid reflux, and ulcers in the stomach or duodenum disappear. DGL supports the lining of the stomach and duodenum and re-establishes the defense against the acidy milieu. Not only that, but after a few weeks of DGL treatment all of the findings on endoscopy such as inflammation and ulcerations disappeared.

DGL restores the stomach lining

Dr. Murray states that he has not encountered a case of gastritis or ulcer that would not have responded. It appears that the cause of gastritis and ulcers in the stomach and duodenum is not from too much acid, not from H. pylori infection, which appears to just be a concomitant infection, but actually is due to a breakdown of the barrier in the lining of the stomach and duodenum, which responds to DGL. The other interesting thing is that you can buy DGL in the health food store; the dosage is two to three chewable tablets on an empty stomach three times per day. According to Ref. 3 the patient has to take DGL 8 to 16 weeks, after which there is a full therapeutic response. Pepto-Bismol is another coating substance that is available over the counter and works well for minor stomach upsets.

4) Chronic back pains and insomnia

Many people see their chiropractor for chronic recurrent back pains and their physician for insomnia to get sleeping pills. It all depends what the underlying causes are of back pains and insomnia. If there is a misalignment in the spine, a chiropractor doing manipulation would be a reasonable approach and the back pain symptoms often disappear. However, thyroid deficiency, adrenal gland insufficiency or adrenal gland fatigue may also be the cause of back pains and muscle cramps. Unless the physician treats the  underlying cause (in the case of hypothyroidism treatment with thyroid hormones), the back pains stay.

Muscle pain in fibromyalgia patients

In fibromyalgia where muscle pains are all over the body, the standard treatment with antidepressants and pain pills just will not do it on the long-term. These patients require a detailed work-up with analysis of the hormonal status. Often, they are suffering from a lack of thyroid hormones, a lack of sex hormones (in women a lack of estrogen and progesterone, in men a lack of DHEA and/or testosterone). But they may also have weak adrenal glands and a lack of growth hormone. An anti-aging physician (A4M) can order the appropriate tests and treat the underlying causes.

Insomnia in fibromyalgia patients

Fibromyalgia patients often have insomnia (sleep disorders). Dr. Lichten (Ref.4) recommends GABA in small doses (125mg to 250 mg) at bedtime along with 500 mg of L-tryptophan. He also recommends 4000 IU – 5000 IU of vitamin D3 (as often insomnia patients are deficient in vitamin D3) as well as 500 mg to 1000 mg of magnesium. If this alone is not sufficient, melatonin, 1 mg to 3 mg at bedtime will be beneficial. Dr. Lichten cautions that GABA leads to tolerance quickly, so the patient should take GABA only 5 days out of 7 to allow the body’s receptors to recover. This alternative approach to treat insomnia prevents addiction to sleeping pills (hypnotics).

5) Asthma symptoms

Not every case of asthma needs steroid inhalers and salbutamol or other bronchodilator inhalers as treatment. Low thyroid hormone levels can also cause asthmatic symptoms of wheezing and shortness of breath. It is important to listen to the patient’s symptoms, but the treatment will only be successful when the cause is treated. Dr. David Derry described in this link how many of his severe asthma patients had iodine deficiency and low thyroid hormones and no longer had to see him when iodine treatment and desiccated thyroid hormone replacement was given as treatment. This goes against what the standard recommendation for asthma treatment is, but it seems to get patients unhooked from dependence on steroid inhalers.

Steroid dependency from anti-asthmatic inhalers can suppress the adrenal glands and lead to adrenal gland insufficiency.

Corticosteroid inhalers in asthma treatment can suppress the stress response

The adrenal glands are vital for coping with stress as the more stress you are under, the more your pituitary gland produces ACTH hormone, which in turn stimulates the adrenal glands to produce cortisol. However, a significant percentage of patients with asthma that been on corticosteroid inhalers for a long time, experience a suppression of the pituitary gland and the adrenal glands cannot produce the required stress hormones; in other words, adrenal fatigue or adrenal insufficiency can set in.

This is an example where corticosteroid inhalers control asthma symptoms, but they undermine the stress hormone circuit to the point where the patient experiences another disease (called a “iatrogenic disease”, a disease from the side-effects of drugs). Treatment of adrenal fatigue is described in this link.

Conclusion

Medicine can become quite complex as these examples show. Many times physicians tell their patients that they do not know the cause of their symptoms. However, this is not always true, but conventional medicine continues to hold onto the old dogmas. With the third example above (gastritis and duodenal ulcer), until the mid 1980’s the original theory in medicine was that too much acid production would be the cause of these conditions and treatment concentrated on suppressing acid production. Then the new theory came up that H. pylori, a bacterium would be the cause of chronic inflammation, which together with too much acid would cause the condition. That is why physicians now treat it with the triple therapy, a good deal for Big Pharma, but a bad deal for many patients.

DGL, a simple licorice compound can strengthen the lining of the stomach

Patients still do not experience a cure, but develop a worsening of their conditions as H. pylori growth proliferates, particularly from the PPI’s, which undermines the lining of the whole stomach. As pointed out above DGL, a simple licorice compound, which is available in health food stores, can strengthen the lining of the stomach and duodenum, which at the same time gets rid of the H. pylori problem without any other drugs.

The problem with conventional medicine is that in many cases physicians still treat symptoms instead of treating known causes. Big Pharma supports this, as it is expedient for them to protect their multi-billion-dollar industry. Patients should ask their physicians to treat the causes of their diseases rather than the symptoms.

References

1. Dr. Edward M. Lichten: Textbook of bio-identical hormones. ©2007 Foundation for Anti-Aging Research, Birmingham, Michigan, USA

2. William Davis, MD: “Wheat belly. Lose the wheat, lose the weight, and find your path back to health.” HarperCollins Publishers Ltd., 2011.

3. Michael T. Murray, ND: “What the drug companies won’t tell you and your doctor doesn’t know”. Atria Books, New York, 2009.

4. Dr. Edward M. Lichten: Textbook of bio-identical hormones. ©2007 Foundation for Anti-Aging Research, Birmingham, Michigan, USA

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Jun
01
2013

Toxins In The Bathroom

This article is about toxins in the bathroom. In the past I never looked at labels on shower gel, hair conditioner or liquid soap. But one day I read that the cosmetic industry uses parabens as a disinfectant in many body care products including cosmetics. That’s when I found out about my major supply of hair care products contained various parabens, like methylparaben, ethylparaben, propylparaben, butylparaben or heptylparaben.

Toxins in the bathroom: Hair care and body care products

Officially, toxicity tests have shown that these substances are safe on the short term. What this means is that in short term experiments (usually up to 90 days) rats did not die from exposure to them. But long-term studies to see whether they would die from cancer have never been done. However, long-term exposure can lead to skin rashes in sensitive individuals (contact dermatitis, rosacea). This is still fairly harmless. Much more concerning are the effects of long-term exposure, which is what happens when we apply these chemicals to our skin every day. Researchers showed that breast cancer specimens (what the surgeon cuts out during surgery) contain parabens, which can be measured in the lab.

Parabens have estrogen-like hormone activity

Further experiments have shown that parabens have estrogen-like hormone activity in animals and humans. They belong into the group of “xenoestrogens”. What this means is that they act like weak estrogens, and this can be cancer causing. In women estrogens are in balance with progesterone, but when parabens or other xenoestrogens are introduced, the estrogens get the upper hand, which can cause breast cancer and uterine cancer. In men where traces of estrogen and progesterone are also present, balanced with the more dominant testosterone, this hormone balance gets disturbed by parabens, and prostate cancer can develop. Why don’t we hear about this more often? Because it is a slow process that may take 20 to 30 years. 

Prostate cancer can be due to long-term exposure to parabens

By that time nobody thinks that breast cancer or prostate cancer could be the result of long-term exposure to parabens. For years the cosmetic industry argued that parabens would be just applied to the skin, not taken internally and for this reason they should be safe. The problem in this sentence is the word “should”. Parabens are absorbed through the skin and enter the bloodstream directly exerting the xenoestrogenic effect. Some parabens occur naturally in very small amounts such as in barley, strawberries, currants, vanilla, carrots, and onions, but they are absorbed by the gut and get destroyed by the liver in the so-called “first pass effect”. I went to the health food store and studied labels. I was able to get clean products (shampoo, conditioner, body wash), which do not contain parabens.

Toxins In The Bathroom

Toxins In The Bathroom

Toxins in the bathroom: Toothpaste

This is a topic, which may get your dentist annoyed. Here are the ingredients to watch for:

Fluoride in toothpaste

1. What most people expect to be in a toothpaste is fluoride. The representative of the toothpaste company told the dentist that fluoride would make the enamel of teeth more resistant against tooth decay. Advertisements also pass this on to the consumer. What is not passed on to you is the fact of fluoride toxicity, which occurs when fluoride gets absorbed into the body. This has the name “skeletal fluorosis”.  Stomach and bowel irritation including irritable bowel syndrome and joint pains are part of this syndrome. In growing children, the enamel of teeth may show discoloration, the bone of adults can get brittle causing wrist fractures.

Displacement of magnesium by fluoride

Fluoride displaces magnesium on a cellular level and this causes metabolic problems in the kidneys and brain as many enzymatic reactions need magnesium as a co-factor. The thyroid can also become hypothyroid, particularly, if iodine was low to start with (fluoride can replace iodine in the body). If you feel you need to brush your teeth once per day with a fluoridated toothpaste, use regular, non-fluoridated toothpaste in between. You can also protect your body by taking iodine capsules once or twice per day to saturate your system with healthy iodine, which makes you more resistant to bromide, chlorine and fluoride toxicity.

Sodium lauryl sulfate

2. Another ingredient on the label is often Sodium lauryl sulfate: this chemical is used to improve the texture of the toothpaste and make it foam up when you brush your teeth. The side effects are irritation of the mucous membranes, may cause canker sores, redness and irritation of the skin around the mouth. It is interesting to note that it also causes fish to die when the wastewater enters the ocean or water streams.

Triclosan

3. This substance has antibacterial and antifungal properties and as such lends itself to prolong the shelf life of body care products (see this review). Manufacturers frequently use triclosan in deodorants, toothpaste and mouthwashes. The FDA did safety checks on triclosan because it is an endocrine disruptor in animals and in humans. It also can cause hay fever, antibiotic resistance and can combine with chlorine from chlorinated water. This causes release of chloroform, which is a known cancer causing substance. Many manufacturers have voluntarily abandoned the use of it.

Saccharin and aspartame

4. The manufacturers of toothpastes often use artificial sweeteners in toothpaste to add sweetness. Although originally thought to cause bladder cancer, saccharine has been cleared of this around 2000 when it was shown that although causing bladder cancer in rats, it was safe in humans. Diabetics have used saccharine safely for over 50 years. Aspartame, however, is more problematical:  there was an intensive investigation by the FDA whether or not aspartame would cause cancer in humans. As this review shows there were methodological flaws in some of the cancer studies so that the FDA finally decided to keep the previous recommendations the same that it was safe to use in diet drinks etc.

Aspartame belongs into the group of excitotoxins

Other researchers disagreed and came to the conclusion that there were interest groups that interfered with the science of investigating safety of aspartame. Aspartame belongs into the group of excitotoxins, substances that can excite the brain and can also cause an existing cancer to metastasize. At this point in time, it is much safer to cut out all aspartame from your diet including your toothpaste.

FD&C blue dye No. 2

5. This blue food coloring agent has been around as food additive since 1906. The FDA approved this coloring agent back then. However, because of renewed health concerns this food coloring was re-reviewed. According to this reference the time exposure in animal experiments was not long enough (page 13 to 19 of this link), but serious complications such as significant brain tumors in rats and borderline higher frequency of bladder tumors and breast cancer were noted. The FDA elected to keep it listed as a safe food coloring agent. Hyperactivity in children is another observation that is of concern to parents. It simply is not worth to use blue, number 2 in toothpaste. Read your labels and leave it out!

Toxins in the bathroom: Hair dyes

With the baby boomers turning grey as they get older, there is an interest in hair coloring. But of course people of any age group may like to change hair color and experiment!  Study labels of different products. You will notice in quite a few of them the familiar parabens as a disinfectant. Other toxins are ammonia, benzene, PPD (p-Phenylenediamine), toluene, coal tar. You find details of these ingredients and their side effects in this link (note a lot have been shown to be cancer producing). The bottom line is: avoid cancer-producing chemicals like the ones just listed. Instead buy your permanent herbal hair color in the health food store or health food section.

Toxins in the bathroom: Cosmetics

Phthalates

In 2010 this Mexican study showed malformations in rodents after exposure of the mother to phthalates. Asthmatic children were also found in another study to have absorbed higher levels of phthalates than children that had no asthma. As a result phthalates have been illegal in many European countries, but not yet in Canada and the US. What should you do about this?

Use a skin product with hyaluronic acid in it

For wrinkles use a product that consists of hyaluronic acid. (I found “Pure Hyaluronic Acid Facial Serum” from Complementary Prescriptions (Carson City, NV) and Yu InfiniSerum, a cream manufactured by Nutrazyne Research LLC, Highland, UT). Between both of those non-toxic skin applications you likely will not need any other cosmetics on your skin. If you feel you do, insist on natural ingredients that do not irritate your skin. Do you really need a lipstick? If you do, do not take one that contains lead or other cancer producing metals as was discussed recently on the news.

Toxins in the bathroom: Mouthwash

Many people feel they have “bad breath” and they need a mouthwash. This is good marketing for companies that produce mouthwash. However, the truth is you need to have your gums looked at, brush your teeth regularly and floss your teeth. If you suffer from constipation, increase your fiber intake and consider colonics. If you still think you have bad breath, use a natural mint product (read the ingredients). Why do I not like mouthwashes? They kill your mouth bacteria that are naturally there; this can disbalance the rest of your gut bacteria as you swallow part of the mouth flora when you eat or drink fluids. If you still want to use a mouthwash, use one without alcohol and without any carcinogens or parabens. Also read this 2009 news item. It is as valid as it was then.

Toxins in the bathroom: Underarm deodorant

Here is an article that points out the danger of antiperspirants and breast cancer. The lesson to be learnt from this is that the propellants of sprays can be deadly when overused. So, use deodorants that are sticks to put or roll on. Next there is the aluminum content, which needs to be “0”. Aluminum is one of the substances responsible for Alzheimer’s disease when exposure to it occurs over longer periods of time. Manufacturers often smuggle parabens in as antifungals/antibacterials.

Hormone disruptors

They are hormone disruptors and xenoestrogens causing breast and prostate cancer. So, no propellants, not parabens, no aluminum! Triclosan is another substance that manufacturers like to add to the ingredients. I mentioned already before that triclosan releases chloroform, which is a carcinogenic substance. To choose the right deodorant it is important to read labels carefully, so you can make informed choices. Look for “aluminum free deodorant”. Next make sure that none of the bad chemicals described above are in the ingredient list. Read this info to educate yourself. Your best bet to find the right product is to go to the health food store or health food section of a store, as they usually carry a selection of natural, non-toxic products.

Conclusion

We owe it to our bodies to protect them from the chemicals that manufacturers produce. They have no concern about their customers’ health. You may ask yourself why cosmetics, toothpaste or other personal care products need to contain carcinogenic substances. It is up to the consumer to make the right choices. And we do have many health-oriented choices available to us now. My hope is that through education we will influence the market to become more health-oriented.

Apr
14
2013

Allergies Not Only In Spring

This article is about “allergies not only in spring”. Springtime is the time of spring allergies: those affected develop a runny nose, itchy eyes and in more severe cases they may experience a flare-up of asthma. Allergies can be triggered by the increase of pollen counts in the air that occurs every spring. In those who are sensitive, this leads to antibody formation in the blood. But often people have not only sensitivities to the pollens of spring bloomers; they may also be allergic to spores from molds, to dust mites and may have underlying allergies to foods.

Memory cells of the immune system

The immune system has memory cells that memorize that a person has had an allergic encounter to one of these items in the past, and allergic reactions can become more significant with a future encounter. Allergies often get worse when a person has food sensitivities and there are cross reactions between pollens of trees or grasses that share surface protein regions with similar protein regions in foods.

Cross allergies

It is known that cross allergies are possible between birch pollen and apple, carrots or hazelnut. In its extreme form allergies due to antibodies, called IgE antibodies, can cause anaphylaxis. A person presensitized by inhaling birch pollen, after eating an apple, hazelnuts or a carrot can develop itching of the throat, swelling of the lips and very quickly deteriorate getting into an anaphylactic shock.

Other cross allergies exist between ragweed pollen, which is a powerful inhalant allergen and melons or bananas. Again there are specific IgE antibodies that are responsible for this immune reaction. In this case the ragweed allergy primes the immune system to produce IgE antibodies, which are experience potentiation by certain foods that share similar protein components as the ragweed pollen.

In the following I will deal with inhalant allergies separately from food allergies.

Inhalant allergies

Inhalant allergies are easier to diagnose and to treat than food allergies. Your doctor will likely refer you to an allergist when you have allergies that do not respond to treatment with intermittent over the counter antihistamines. Your symptoms may come on in the spring with itchy eyes and a runny nose. From year to year you find that you become more and more dependent on antihistamines and nose drops to unplug your nose. The allergist likely will do sensitivity tests, which consist of skin prick or scratch tests on the back or the forearms.

Allergy shots to stabilize allergies

In more serious allergies, where the patient has coughing and wheezing attacks following allergic reactions, the allergist may suggest to start intermittent allergy injections alongside the standard inhalation therapy for asthma. The allergist prescribes an allergy serum where the lab mixes ingredients based on all of the positive tests that led to a strongly positive skin reactions through allergy testing.

Allergy injections

Typically, the family doctor or his nurse will start the allergy injections initially in weekly intervals.  After reaching the  maintenance dose, there may be a modification to injections every 10 to 14 days.

The allergy injections stimulate the immune system to produce harmless competing antibodies, which counteract the disease producing allergic antibodies. In the process of desensitization shots the immune system will normalize, which means that the inflammatory response of the immune system settles down to normal.

This is not the end of the story with inhalant allergies. The allergist needs to retest the patient on a yearly basis. The immune system changes all the time as new allergies can develop and old ones may go away.

Retesting allergies and sublingual immunotherapy

Retesting is necessary to keep track of what is going on and to change the composition of the allergy serum. Those patients who are working together with the allergist can do very well, and often they gradually outgrow their allergies. Others may not be so lucky. They may have reactions to the allergy injections. In these cases avoidance of what causes the allergy may be the only solution to treat the allergies.

There is an alternative to allergy injections, which physicians in Europe use, namely a sublingual immunotherapy. Recently there has been a review of the literature for FDA approval that is needed for oral desensitization for ragweed, dust mites, grass pollen and cat dander. It will take some time before the FDA approval process will become a reality for sublingual desensitization in the US.

Allergies to pets

A special form of inhalant allergies are allergies to pets (mainly dogs and cats, but also allergies to petting zoo animals). The dander that the human comes in contact with is a protein from the animal hair. It causes hives when it touches the skin. This occurs as the dander penetrates through the skin and meets the local mast cells that release histamine. This in turn is responsible for the hive formation. Sneezing and even asthma can develop from inhaled protein particles that reach the lungs. Allergy injections for the treatment of animal dander allergies often do not help or make the allergies worse. The allergist usually recommends avoidance of animal contact as the solution, a recommendation, which the affected animal lover often does not appreciate.

Allergies Not Only In Spring

Allergies Not Only In Spring

Food allergies

Often we eat  some foods more frequently, because they are our favorites. This means that our gut lymphocytes that get in contact with these foods can start to react to one or more of the foods we ingest. At this time we may experience abdominal cramps, diarrhea, vomiting and a host of other possible symptoms.

The physician will tell the patient that testing for food allergies is a problem. Most of the usual skin tests employed for inhalant allergies do not reliably work in determining food allergies. The doctor will ask the patient or the mother of the child with food allergies to keep a food diary and keep track of the allergic symptoms in the diary as well. An elimination diet will have to be devised based on the information gathered in the diary as it becomes clear from that record which foods cause which symptoms. The foods causing allergic symptoms are subsequently eliminated. This is a cumbersome process, but it is the most reliable method of testing and treating food allergies.

RAST test

In the past there was a blood tests, called RAST test, which tested for common food allergies that can cause severe allergic reactions like egg, milk, peanut, tree nuts, wheat, crustacean shellfish and soy. Since about 2010 this has been replaced by the more sensitive ImmunoCAP Specific IgE test.

Children often develop food allergies to egg, milk, wheat, nuts, peanuts and soy, which are food allergies with positive IgE tests. When they age, their immune system develops tolerance to many of these foods and they often outgrow these allergies.

Antibody tests for food allergies

Only a blood drop is necessary to test a panel of foods with IgG, IgM and IgE antibodies. A number of suppliers offer these tests.  However, the specificity, sensitivity and reliability can pose problems with regard to the interpretation of the results. Allergists often point out that a test may be a false positive when a person likes certain foods. IgG antibodies against this food show up despite the patient having no symptoms. Another specialist may interpret this to indicate that the body shows early sensitization to a certain food.  However, clinically it is not yet obvious. In other words, the sensitivity of the test is so high that it undermines the validity of the test. Recently a panel of international scientists reviewed the validity of these IgG based food intolerance tests and they found the tests not reliable.

Testing for food allergies

The immune responses to food allergies are complex as there are immediate type immune reactions and delayed type immune reactions. The physician investigates the immediate immune responses with the above mentioned ImmunoCAP Specific IgE test. The delayed immune responses can be measured using the ELISA test.

Other considerations about allergies

You see from this discussion that a patient with allergies needs a properly trained allergist who will do a comprehensive analysis involving a thorough history, examination, blood tests and immune tests.  The specialist interprets the test results, which requires his/her experience and clinical judgment.

Clearfield wheat

Since the 1970’s when Clearfield wheat was introduced around the world on a large scale, which has a much higher gliadin (gluten) content than the old wheat varieties. As a result of exposure to this new type of wheat gluten intolerance and leaky gut syndrome have increased. Scientists registered a substantial increase in wheat gluten intolerance in the world population. Genetically modified foods like soy, corn, sugar beets, canola and more are a challenge for the immune system. This is particularly so  in sensitive humans. Physicians do not fully understand why this is so. We do know that some people can develop autoimmune diseases. This may be the reason that a host of diseases are much more common now than in the past. Common autoimmune diseases are MS, rheumatoid arthritis, Hashimoto’s thyroiditis, ankylosing spondylitis and others.

Epi-Pen, chronic inflammatory diseases

After food elimination for 2 to 12 months depending on the severity of the food allergy, your body may have eliminated the allergy to the food you have avoided, in other words your body built up tolerance. Before you expose yourself to any food that you used to be allergic to and that you want to re-test, it is best to have an EpiPen ready in case your allergy has not resolved. Caution is necessary with regard to foods that cause more severe allergies, e.g. shellfish or peanuts. These type of allergies may last life long. It is safer to avoid these foods that cause more severe allergies altogether.

Chronic inflammatory diseases

Allergic reactions of the immune system belong into the category of chronic inflammatory diseases. These are known to be the root of chronic diseases like asthma, arthritis, heart disease, high blood pressure and cancer. Be vigilant about allergies and get proper assessment and treatment by an allergist. You will prevent serious health problems including the above mentioned chronic diseases.

More on asthma, which is a chronic inflammatory lung condition, often associated with multiple environmental allergies:

Dec
01
2008

Treating Gastroesophageal Reflux Helps Asthmatic Kids

Asthma in children can be associated with allergies, but as Dr. Aaron K. Kobernick reported recently, other health conditions can also contribute to childhood asthma. He found that approximately two thirds of children with persistent asthma who had no allergic symptoms had another health condition, namely gastroesophageal reflux disease. The condition of acid reflux aggravates asthma. A prospective study examined children with moderate persistent asthma over a 2 year period. Initially the children underwent spirometry testing to assess their lung function. Another test involved monitoring of the acidity (ph values) in the esophagus of those children. The latter test demonstrated that the majority of the asthmatic kids also had GERD (gastroesophageal reflux disease).

Treating Gastroesophageal Reflux Helps Asthmatic Kids

Acid reflux aggravates asthma

 

 

 

Those children who were free of acid reflux received asthma medication only, but the patients with acid reflux and asthma received medication to treat the reflux.
In some cases surgical intervention was necessary. It became apparent that the children whose reflux was treated either surgically or with medication had an improvement of asthma symptoms of 22 to 25 %, whereas asthma medication alone contributed only to an improvement of 11%. Dr. Kobernick concluded that the large airways can react to the exposure of stomach acid, which results in an aggravation of asthma symptoms. Treating the acid reflux condition will result in less asthma in young patients with GERD.

More information on:

1. Asthma: http://nethealthbook.com/lung-disease/asthma-introduction/

2. GERD: http://nethealthbook.com/digestive-system-and-gastrointestinal-disorders/acid-reflux-gerd-esophagitis-barretts-esophagus/

Annual Meeting of the American College of Allergy, Asthma, and Immunology, November 6 – 11, 2008, Seattle, Washington

Last updated Nov. 6, 2014

Oct
01
2008

Go Easy On Tempra And Tylenol In Young Kids

With cold and flu season around the corner, the medicine shelf will fill up with remedies that provide symptomatic relief for those who caught a bug. Children who have an elevated temperature will very likely receive over the counter medication such as Tempra drops or Tylenol for children. These preparations have been around for decades, and parents are usually confident that they are harmless.
A Lancet article points out that there are certain risks associated with them, and the most sensitive age group are the youngest children. A study documented that the mother’s use of paracetamol (identical to acetaminophen or Tylenol) during pregnancy can be associated with the development of asthma in 6 to 7 year old children. More recently 205,487 children in the age group of 6 to 7 were included in a survey. The children were from 73 centers in 31 countries. In the analysis of data the use of paracetamol in the first year of life was checked against the risk of asthma symptoms once the children were 6 to seven years old. Paracetamol use in the first year of life also played a role in the increased risk of rhinoconjunctivitis and eczema.

Go Easy On Tempra And Tylenol In Young Kids

Go Easy On Tempra And Tylenol In Young Kids

With these results, parents should resort to the children’s’ Tylenol and Tempra drops only, if fairly aggressive intervention is necessary. Too often over the counter meds are used “just in case he or she is coming down with something”. Symptomatic home remedies in children such as lukewarm baths to bring down an elevated temperature, cool fluids bring relief, and ice packs still have their place in the control of mild febrile symptoms.

The Lancet 2008; 372:1039-1048

Last edited December 3, 2012

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Jun
01
2008

Boost Babies’ Health with Mom’s Diet

Prenatal supplements and good advice on proper nutrition during pregnancy have long been included in proper prenatal care. Importance has been placed on folic acid to prevent neural tube defects in the fetal development. Calcium is recommended, often in the form of dairy products, but it does not end there: just swallowing the supplement and adding some more milk may be helpful but not quite enough. Certain dietary habits have been found more beneficial, such as the eating habits in the Mediterranean countries. A research team from the University of Crete in Heraclion, Greece included women who were involved in antenatal care at all general practices in Menorca, Spain. The study took place in the time frame of 12 month starting in 1997. After six and a half years 460 children were also included in the analysis.

Dietary habits were studied and assessed by food questionnaires and the children were assessed for the development of allergies and asthma.

Boost Babies’ Health with Mom’s Diet

Boost Babies’ Health with Mom’s Diet

The children of mothers who consumed the most vegetables, fish and legumes were almost 80% less likely to have persistent wheeze and more than 40 % less likely to have allergies. The results are consistent with the fact that a high level of adherence to the Mediterranean diet during pregnancy is protective not only to the mother but also to the child.

More information about prenatal visits (where nutritional habits are checked as well): http://nethealthbook.com/womens-health-gynecology-and-obstetrics/pregnancy-labor-delivery-2/prenatal-visits/

Reference: The Medical Post, April 22, 2008, page 25

Last edited December 18, 2014

May
01
2008

Tree Pollen Connected With Mood Disorders

Seasonal affective disorder (SAD) does have its grip on people who react to a lack of sunlight in the winter month. As a result depression in the winter season is not uncommon. Some people just report it as feeling “down” and “tired” or report a lack of energy. Despite all the reports about SA, epidemiological studies have shown that the rate of depression is not the highest in dreary months like January or February but it spikes in the months of April and June. Dr.Teodor Postolache, a psychiatrist at the University of Maryland made a recent presentation at a meeting of the American Acadamy of Allergy, Asthma and Immunolgy delving into the reason for this finding. He compared the exposure of tree pollen which triggers a cytokine release to a tsunami.Virtually no outdoor allergens are present in the winter months, but with the release of tree pollen people who are vulnerable to allergies are exposed to massive amounts of allergens. The released cytokines may affect brain function and behaviour, resulting ultimately in changed cortisol levels and an altered serotonin metabolism. After breathing the cytokines are already released in the nose and they can continue their action in the prefrontal brain area where the centers for mood, anxiety and impulsivity are located. Dr. Postolache and his colleagues confirmed that individuals with a history of allergy and asthma had a 2.5 fold of suicide compared to controls and those with allergic rhinitis had a 1.7 fold higher risk.

Tree Pollen Connected With Mood Disorders

Tree Pollen Connected With Mood Disorders

For the first time it could also be demonstrated that cytokine levels in suicide victims were significantly elevated in the orbitofrontal cortex, the brain area that affects mood. Intranasal corticosteroids in the form of nosedrops can bring significant relief to allergy sufferers, and Dr. Postolache and his team will examine the benefits of intranasal corticosteroids closer  in a clinical study. Whereas systemic corticosteroids have shown a negative impact on mood disorders and depression, the local application of a nasal spray or drops is geared to abolish the pathways from the nose to the brain for the inflammatory cytokines.

More information on seasonal rhinitis: http://nethealthbook.com/ear-nose-and-throat-diseases-otolaryngology-ent/nose-problems/allergic-rhinitis/

Reference: The Medical Post, April 1, 2008, page 1, 34

Last edited November 3, 2014

Jul
01
2007

Asthma And Bronchitis From Exposure To Chlorinated Water In Infancy

Every new parent has the wish to stimulate infants in healthy development. Children’s programs are plentiful, whether they involve gymnastics and dance or toddlers play. It is no surprise that swimming classes are also offered, and parents are not only looking at the water fun but also at water safety. They want the best for their baby and make use of swim groups that are offered for babies and infants.

It turns out that it may be better to hold off on putting baby into swim classes at the public indoor pool. The water is fine, but the chlorination is the problem. It is common to see a irritation of the eyes due to chlorination, but data reported in the June issue of Pediatrics described findings from a group of 341 school children age 10 to 13, 13% of whom had participates in infant swimming programs point to damaging effects on the respiratory organs. Among others the respiratory condition of these children was assessed. The infant swimming group had signs of so-called Clara cell damage and changed permeability of the lining of the lung. The group that had been enrolled in infant swim groups also had significantly elevated odds of having chest tightness, physician-diagnosed asthma and exercise-induced airway constriction. The problems were aggravated even more, if the children were exposed to parental smoking.

Asthma And Bronchitis From Exposure To Chlorinated Water In Infancy

Chlorinated water exposure during childhood leads to asthma later in life

The researchers conclude that infant swim practice in chlorinated indoor swimming pools is associated with airway changes, which along with other factors can predispose children to the development of asthma and recurrent bronchitis. More research is recommended to examine the effects of chlorination products on the infant respiratory tract.

More information on asthma: http://nethealthbook.com/lung-disease/asthma-introduction/

Reference: http://www.ncbi.nlm.nih.gov/pubmed/20075053 : Voisin C, Sardella A, Marcucci F, Bernard A.: ” Infant swimming in chlorinated pools and the risks of bronchiolitis, asthma and allergy.” Eur Respir J. 2010 Jul;36(1):41-7. Epub 2010 Jan 14.

Last edited November 2, 2014

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Jul
01
2007

Incense Use Causes Cancer Of The Respiratory System

Incense use has been common in East Asia for a long time, but also in the Western world incense burning is not uncommon. It became very much “in” to burn incense sticks to create a certain “atmosphere” in a room. Incense burning during religious celebrations in some churches is a custom that goes back well over 1000 years. It is easy enough to observe, how a cloud of incense triggers a chorus of coughing and clearing of throats in a church ceremony. It has never been a laughing matter to people who suffer of allergies and asthma, as incense smoke –just like any other smoke- is a source of airway irritation.

But a bit of a cough and airway irritation are the smaller problems that long term incense use has in store. A study involving 61,320 Singapore Chinese showed that long term users had more than twice the relative risk of non-nasopharyngeal cancers of the upper respiratory tract, compared with people who did not use incense. The risk of squamous cell carcinomas of the lung rose 1.7 fold and the risk of squamous cell carcinomas of the entire respiratory tract rose 1.8-fold among long-term incense users, wrote Dr. Fribourg and his colleagues of the University of Minnesota, Minneapolis who conducted the study. The participants in the study were 45 to 75 years old and free of cancer when they enrolled in the study from 1993 to 1998. Living conditions, life style and dietary factors were examined and results were adjusted for a host of factors, such as cigarette smoking, alcohol intake, gender differences, and intake of Chinese preserved food.

Incense Use Causes Cancer Of The Respiratory System

Incense Use Causes Cancer Of The Respiratory System

The researchers also noted that incense burning is deeply engrained into the way of daily living in Southeast Asia. About half of the population burns incense at home every day. Incense smoke contains a large amount of particular matter and the burning releases many possible carcinogens including polyaromatic hydrocarbons, carbonyls and benzene.

More information regarding nose cancer: http://nethealthbook.com/ear-nose-and-throat-diseases-otolaryngology-ent/nose-problems/nose-cancer/

Reference: First published June 21, 2007 and subsequently published in a 2008 journal.

Last edited November 2, 2014

Dec
01
2006

Asthma Medication May Not Be Enough

Doctors at an asthma clinic in New York were puzzled as to why their patients were not getting better even after continued medical care. Even though the patients were compliant with their medications, they needed oral steroids and presented with more severe asthma attacks at the emergency department. Looking into the living conditions of the patient group that continued having problems provided some insight: they lived in housing units that were dilapidated. In a program in which St. Luke’s-Roosevelt Hospital and other clinics participated, with the help of legal services of an attorney law firm the hospital was getting help for patients, who lived in substandard housing. When a patient lived in a building with dust, mold, roaches or rodents, any amount of treatment for asthma was almost futile. Even though there were letters and phone calls from social workers to landlords, unacceptable conditions in these housing units were not corrected. One letter from the New York Legal Assistance Group finally did the job. In plain English the notice to the negligent landlord said: Clean the place up or see me in court.

Dr. Luis Chug at St. Luke followed up on the patients one year later. Patients who needed 18 courses of oral steroids could reduce the treatment to just 2 the year after the cleanup. Patients who had made 14 trips to the emergency department because of asthma attacks the year before made only 2 after the conditions were corrected. The overall asthma of the patients also improved. Ten patients were afraid to go to a lawyer to seek help. A year later their living conditions predictably had remained the same. Their asthma had not improved either. The legal action was cost effective, reported Dr. Chug. Each emergency visit cost the hospital about $470 in services, and each course of prednisone cost about $345. The patients do not pay legal fees. Instead the service is funded by grants from participating hospitals. The study shows very clearly how practical public health measures can be used to correct health problems. The legal processes available in New York City are not unique in North America, as many local and regional governments have statutes requiring proper building maintenance.

Asthma Medication May Not Be Enough

Substandard housing bad for asthma

The results are also relevant to asthma patients who are not struggling with substandard housing. Patients with asthma simply cannot get better, when they live among irritants and allergy causing substances. Dust, cigarette smoke, perfumes, home fragrances, vapors from household cleansers, animal dander from house pets or feathers from a seemingly cozy down comforter can be the culprits for patients with asthma that does not improve despite treatment.

More information about:

1. asthma: http://nethealthbook.com/lung-disease/asthma-introduction/

2. mold allergies: https://www.askdrray.com/mold-allergies-often-overlooked/

Reference: The Medical Post, November 14, 2006, page 23 and 25

Last edited November 2, 2014