Apr
23
2016

Healing Powers Of Green Tea

Powerful catechins that are a special form of bioflavonoids provide the healing powers of green tea. Research teams have proven that these catechins are only contained in green tea, not so much in black tea. The most effective of several catechins contained in green tea is EGCG, which stands for EpiGalloCatechin-3-Gallate. It crosses the blood/brain barrier and is very important for the protection of the brain from Alzheimer’s disease. But green tea or green tea extract has a diversified pharmacological action. It is said to protect you from cardiovascular disease, from obesity, from diabetes, from autoimmune disorders, from cancer and from Alzheimer’s and dementia.

In the following I like to comment on how green tea or its extract can protect from all of these diseases.

Alzheimer’s disease

Although there are 5 or 6 approved anti-Alzheimer’s drugs, none of them work for very long. They may at best postpone the deteriorating memory for 6 months, but then the effect of the drug wears off. The reason is that the drugs do not stop the production of the deadly beta-amyloid. It is the beta-amyloid that damages nerve cells that you want to preserve so you can think and memorize. In contrast a simple phytochemical, the catechin EGCG has been shown in animal experiments and in human trials to stop beta-amyloid production and increase solubility of beta-amyloid fragments in the brain. The end result is better memory and no further deterioration.

In a study of 13,988 elderly Japanese observed over 3 years the group that consumed 3 to 4 cups of green tea daily had 33% less strokes, cognitive impairment and osteoporosis.

Researchers at the University of Basel, Switzerland enrolled 12 healthy volunteers aged 21 to 28 and fed them extracts of green tea or placebo fluid via feeding tubes. This was done to rule out taste as a factor. Functional MRI scans were applied as the subjects were given memory-stimulating tasks. Only the green tea extract was boosting activity in the frontal brain of the subjects. This was located in a specific area, called dorsolateral prefrontal cortex. This area is known to be involved with language comprehension, reasoning and learning. It also switches short-term memory into long-term memory, called working memory processing.

Studies in animals have shown that nerve cells are protected from the toxic effect of beta-amyloid and at the same time the production of new brain nerve cells (neurons) is triggered by green tea extract. This is really good news for Alzheimer’s disease patients and their families: green tea extract delays further memory deterioration and stimulates the development of new nerve cells in the brain!

Cardiovascular disease

In a 2006 Japanese study 40,530 Japanese adults aged 40 to 79 years without history of stroke, coronary heart disease, or cancer at baseline were observed for 7 years. Diaries were kept about how many cups of green tea each person was drinking per day. The biggest effect was seen with regard to prevention of heart attacks and strokes.

Men had a mortality reduction of 12% for heart attacks when they drank 5 cups or more of green tea; in women the corresponding mortality reduction for heart attack was 31%, a bigger effect. Overall mortality from strokes was lower than from heart attacks making the effect of green tea consumption even more beneficial with respect to stroke prevention. In this study no cancer preventing effect was observed for green tea.

Obesity

It appears that green tea increases heat production and burns fat in the process. There was a small effect in terms of weight loss and a beneficial effect increasing the protective HDL cholesterol in this 2012 Polish study on obese patients. The authors compared either 379 mg of green tea extract, or a placebo, daily for 3 months. They concluded: “The results of this study confirm the beneficial effects of green tea extract supplementation on body mass index, lipid profile, and total antioxidant status in patients with obesity.”

Diabetes

Although there are claims in some studies that green tea would prevent diabetes, this question was thoroughly investigated in this Chinese 2014 study.

No effects were noted on fasting blood sugars or on hemoglobin A1C values, a very sensitive indicator for the presence or absence of diabetes. All these lab tests were unchanged following consumption of green tea or green tea extract. Forget using green tea for diabetes prevention; cut out sugar and starchy foods instead.

Autoimmune disorders

Sjogren’s syndrome and lupus are both autoimmune diseases. Green tea extract has shown in humans that symptom severity can improve; green tea polyphenols (GTPs) possess anti-inflammatory properties that benefit patients with autoimmune diseases.

In an animal model arthritis researchers determined that T helper cells are weakened and bone resorption is inhibited by EGCG from green tea extract.

Researchers at Harvard Medical School, Boston, MA have noted that green tea extract is useful in calming down the immune response in autoimmune diseases. They concluded: “Altogether, these studies identify and support the use of EGCG as a potential therapeutic agent in preventing and ameliorating T cell-mediated autoimmune diseases.”

Cancer

Many research papers have found that EGCG from green tea extract has immune modulatory effects that are useful in combination with chemotherapy. A combination of cisplatin therapy with green tea extract has been found to have more effects on colorectal cancer and ovarian cancer than each one on its own. Similarly chemotherapy of breast cancer had better results in humans when EGCG from green tea extract was added as an immune modulation. More research, particularly in humans is needed to fully understand the mechanism of action of EGCG.

Toxicity of green tea extract

Animal experiments showed that higher doses of green tea extract could cause toxicity in the liver and in the nose of rats and mice. I was not able to find objective evidence for green tea toxicity in the PubMed system with respect to humans.

Healing Powers Of Green Tea

Healing Powers Of Green Tea

Conclusion

Perhaps the most important discovery regarding green tea extract is that it crosses easily through the blood/brain barrier into the brain. This can postpone Alzheimer’s disease and can even lead to new neuron formation. The beneficial cardiovascular effects are also useful and combine well with exercise and good nutrition for prevention. Particularly stroke prevention is a useful property of EGCG from green tea extract. The effect on obesity is marginal whereas there was no effect of green tea on prevention of diabetes. The immune modulatory effect of green tea extract is useful in the treatment of autoimmune diseases and of cancer. Existing treatments for these conditions are becoming more effective by adding green tea extract.

Mar
19
2016

Book Review: “Healing Gone Wrong – Healing Done Right”, By Ray Schilling, MD

This book entitled “Healing Gone Wrong – Healing Done Right” (Amazon, March 18, 2016) is dealing with the practice of medicine then and now. Medical errors, false diagnoses and wrong treatments are nothing new in the history of medicine. It happened in the past, and it is happening now. My first book dealt with anti-aging and was entitled “A Survivor’s Guide to Successful Aging” (Amazon 2014).

Book overview

Chapter 1 describes that famous people like President Kennedy, Elvis Presley, Churchill, Beethoven or more recently Michael Jackson have something in common: all of them suffered the consequences of blatant medical mistakes. In Beethoven’s time lead containing salves to plug the drainage holes from removing fluid from his abdomen caused lead poisoning. In this chapter I review also how the illnesses of the above-mentioned celebrities were treated, but then ask the question: “What could have been done better to prevent some of the disastrous treatment outcomes?”

Chapter 2 deals with how modern drugs seem to come and go. We learn that twenty-first century medications that are touted as the latest therapeutic agents are having their potentially deadly consequences too: COX-2 inhibitors, the second generation of “improved” arthritis drugs cause strokes and heart attacks! Your doctor may still prescribe some of these dangerous drugs for arthritis now.

Chapter 3 deals with the fact that medical treatments for people’s diseases may be inappropriate when the doctor treats only symptoms, but nothing is done about the causes of their illnesses. This is a scary thought.

Chapter 4 asks the question whether we could learn something from these poor health outcomes in the past, so that we will be able to prevent any disastrous outcomes pertaining to our own health care in the present and future. As we will see, the problem today is still the same as it was in the past, namely that many physicians still like to treat symptoms instead of the underlying cause of an illness. Even though Big Pharma has the seducing concept of a pill for every ill, it is not always in your best interest, when these medications have a slew of side effects. “Gastric reflux” means a mouthful of stomach acid. This is a fact the suffering patient knows already! Big Pharma simply offers the patient with the symptom of gastric reflux a multitude of medications to suppress this symptom. But it is more important to dig deeper to find the reason for the illness and treat the underlying cause.

Chapter 5 concentrates on the brain and how we can keep our brains functioning optimally until a ripe old age. This review spans from prevention of head concussions to avoiding type 3 diabetes (insulin sensitivity from overconsumption of sugar). It manifests itself in Alzheimer’s disease. It is a form of diabetes of the brain that leads to deposits of a gooey substance. Prevention of this condition is also reviewed .

Chapter 6 reviews what we now know about how to keep a healthy heart. Certain ingredients are necessary such as regular exercise, a healthy Mediterranean diet, supplements etc. The good part is that what is good for the heart is also good for the brain. You are preventing two problems (brain and heart disease) at the same time.

Chapter 7 delves into the question why healthy food intake matters. Without the right ingredients of our body fuel, the body machinery will not work properly. The Mediterranean diet is an anti-inflammatory diet that is particularly useful.

Chapter 8 talks about healthy limbs, bones and joints. We are meant to stay active in our eighties and nineties and beyond. No osteoporosis, no joint replacements, no balance problems that result in falls! Learn about how to deal with problems like these in this chapter.

Chapter 9 deals with detoxification. What do we do as we are confronted with pollution, with radiation in the environment and poisons in our daily food? A combination of organic foods, intravenous chelation treatments and taking supplements can help us in that regard.

Chapter 10 deals with reducing the impact of cancer in our lives. A lot of facts have come out in the past 10 years telling us that reduction of sugar and starchy food intake reduces cancer. Curcumin, resveratrol and vitamin D3 supplements also reduce cancer rates as does exercise and stress management. All of this is reviewed here.

Chapter 11 checks out your hormone status. Women need to avoid estrogen dominance; both sexes need to replace the hormones that are missing. By paying attention to your hormonal status and replacing the missing natural hormones with bioidentical ones, most people can add 10 to 15 years of useful, active life!

Chapter 12 is refining some of the thoughts about anti-aging. You will learn about the importance to keep your mitochondrial DNA healthy. Apart from that there are ways how to keep your telomeres longer; certain supplements that are reviewed will help. Also your lifestyle does make a big difference in how old you can turn.

Chapter 13 investigates the limits of supplements. Many supplements are useful, but you do not want to overdo it and get into toxic levels. More is not necessarily better!

Chapter 14 reviews an alternative approach to treating ADHD. Attention deficit and hyperactivity disorder has been over diagnosed, has been neglected and has been over treated with dangerous drugs. An alternative treatment plan is discussed, which includes a combination of therapeutic steps.

Chapter 15 gives you a brief summary of the book.

Kirkus Review

Kirkus Reviews reviewed the book on March 17, 2016: “A retired physician details how various preventative measures can fend off disease and disability in this consumer health guide. Schilling (A Survivor’s Guide to Successful Aging, 2014) had a family medicine practice in Canada for many years before retiring. Although Schilling ventures into some controversial territory in his latest book, it’s generally an engaging, helpful synthesis of ideas that draws on reputable research from the Mayo Clinic and other sources. Overall, it serves as an intensely detailed wake-up call to the importance of preventative health. He largely brings an accessible and even-tempered tone to his narrative, warning readers, for example, that preventative health measures can only aid in “a delay of aging, not ‘eternal living.’ ” A thought-provoking, impassioned plea to be proactive about one’s health.”

Healing Gone Wrong – Healing Done Right

Healing Gone Wrong – Healing Done Right

Conclusion

In this book it becomes evident that it is better to prevent an illness whenever possible rather than to wait for illness to set in and cause disabilities or death. You heard this before: “Prevention is better than a cure” or “an ounce of prevention is better than a pound of cure”. I will give an explanation, based on scientific data that there is indeed evidence to support these notions on a cellular level. The mitochondria, the energy packages within our cells, are the driving force that keep people vibrantly healthy well into their nineties. All this can only happen when the mitochondria function properly. If the mitochondria are poisoned and as a result of toxins malfunction, we are not looking at a person with vibrant health. Instead sixty or seventy year-olds may be confined to a wheelchair. If you want a life without disabilities, a life without major illnesses and enjoy good health to a ripe old age, you are reading the right book.

The book is written in American English.

Available in the US: http://www.amazon.com/gp/product/1523700904

In Canada: https://www.amazon.ca/Healing-Gone-Wrong-Done-Right/dp/1523700904/  

In other countries the book is available through the local Amazon websites.

Feb
27
2016

Orthopedics Without A Knife

At the 23rd Annual World Congress on Anti-Aging Medicine on Dec. 12, 2015 in Las Vegas Dr. Fields gave a talk entitled “Regenerative orthopedics – non-surgical repair with stem cells/PRP/prolotherapy. In essence the talk was about alternative treatments to surgeries in orthopedic medicine.

Dr. Peter Fields, MD, DC is a board certified medical physician and chiropractor. He is the director of the Pacific Prolotherapy & Medical Wellness Center in Santa Monica, CA.

Introduction

Joints, muscles, tendons, ligaments and joint capsules control the movements in joints. Due to injuries and wear and tears these body parts can have a lack of function, and this will lead to pain and disorders. The result can be weak, torn or damaged ligaments and tendons, arthritic changes, excessive joint motion, increased pressure, and a decrease in range of motion.

This is the common treatment cycle in medicine: joint pain prompts you to see the doctor. You are told it is arthritis, and you get non-steroidal anti-inflammatories (NSAID’s). You come back with more pain, and you’ll get a stronger NSAID prescription. Eventually a cortisone injection is given, which helps for a few months, but then the pain reoccurs. The doctor arranges for an MRI scan. A referral to an orthopedic surgeon is likely to be the next step, and an arthroscopy (pinhole surgery) is arranged. If this does not resolve the pain, surgery like a knee replacement or hip replacement is suggested.

Common sayings when traditional medicine has nothing to offer: You may have heard some of these common sayings before. “Nothing more we can do about it!” -“I suggest you learn to live with it”- “You should never play that sport again!”- “Take these pain medications” and “The only alternative is surgery!”

The problem is, that none of these pieces of advice are really helpful. This type of approach does not treat the cause; it is directed against symptoms.

How to treat the cause?

  1. Prolotherapy is a natural, non-surgical method to assist the body to heal torn soft tissues. It works in cases like torn ligaments, damaged tendons, cartilage, menisci or a torn labrum in the shoulder. Hyperosmolar dextrose solution is injected into the injured area. This stimulates the body’s healing forces and the body repairs what is damaged. More information is found here. Prolotherapy fixes the cause, not just the effect; it heals, and it is permanent. Prolotherapy strengthens tissues, relieves pain and increases the range of motion in joints. There is 80 to 85% full pain relief and more than 80% improvement in range of motion. Prolotherapy promotes the healing of torn or damaged ligaments and tendons. Suitable conditions to be treated with prolotherapy are sports injuries, muscle tears, arthritis, tendinitis, bursitis, sciatica, TMJ problems, and fibromyalgia. Common areas treated with prolotherapy are the hip, knee, shoulder, ankle, neck, lower back and elbow. Dr. Fields showed MRI scans before and after prolotherapy treatments of ligament injuries within the knee and of shoulder ligament tears before and after treatment. Normally these injuries would have been expected to have needed surgery. But all that was done was one or two injections (prolotherapy treatments) with reactivation of the affected joint. There were astounding results shown with MRI’s before and after herniated disc injuries and how they healed in a relatively short time following prolotherapy.
  2. PRP prolotherapy: platelet rich plasma (PRP) is a tool from regenerative medicine that is used in connection with stem cell therapies to amplify the healing response.  Blood is taken from the patient’s own blood. The blood is subsequently spun down in a centrifuge. The platelet rich fraction (PRP) contains all of the growth factors, which have the healing power of the blood, and this can be combined with prolotherapy to make healing even more successful. This is particularly useful for labral tears in shoulders, meniscus tears in knees and other localized injuries.
  3. Stem cell prolotherapy: Stem cell therapy has been the gold standard for repairing more serious problems. Dr. Fields is using stem cell therapy combined with prolotherapy to treat more serious injuries like end stage arthritis when bone rubs on bone, where conventional orthopedic medicine would offer a joint replacement in the hip or knee. Any joint that has cartilage damage can also be repaired much simpler with stem cell prolotherapy. A severe meniscus tear in a knee or a severe labrum tear in a shoulder would also be situations where stem cell prolotherapy is superior to surgery or to just using prolotherapy alone.

Here is how the procedure is done: Before the patient’s procedure the physician first harvests bone marrow stem cells by way of a pelvic bone aspirate; secondly, mesenchymal stem cells from fatty tissue are obtained by aspiration of abdominal fat. A cell separator provides the stem cell fractions. Both types of stem cells, the bone marrow stem cells and the mesenchymal stem cells from fat, are mixed as each one has its own strengths and combined they are more effective in repairing whatever tissue needs to be repaired. Thirdly, the patient’s blood is harvested as described above to obtain PRP, which contains the growth factors needed to activate the stem cells to do their job of healing. The last step is that the physician now combines hyperosmolar dextrose (the prolotherapy part) with the stem cell preparation and mixed in PRP and injects this mixture into the injured area. This procedure has superior healing power. Judging from the before and after MRI scans regarding all of the major body regions mentioned above, and seeing several video recorded testimonials it is surprising how quickly and completely fairly severe injuries can heal using stem cell prolotherapy. One particularly nasty condition is osteonecrosis of the hip, which can occur as a side effect of chronic cortisone treatment for arthritis, asthma or chronic obstructive lung disease. One or two stem cell prolotherapy treatments will heal this condition because the stem cells build up brand new bone and get rid of the old necrotic bone from the osteonecrosis. Conventional medicine has no answer for this condition. Regenerative orthopedics is successful by using stem cell prolotherapy.

What are the advantages of regenerative orthopedics?

Regenerative orthopedics reduces pain very quickly and it improves function rapidly. Healing occurs naturally, and it strengthens the tissues involved. Particularly complicated lower back pains or lower neck pains (due to degenerative disc disease, facet joint osteoarthritis, spondylolisthesis and significant foraminal stenosis) respond really well to stem cell prolotherapy, getting rid of chronic pain. Again before and after MRI scans were shown and testimonials given. This is quite in contrast to what conventional orthopedics has to offer: discectomy with fusion surgery, where the patient often has scar pain later. With a laminectomy to treat a foraminal stenosis the patient may have limited improvement of the chronic back pain for a couple of months, only to experience new back pain from a subsequent spinal stenosis as a late complication from the prior surgery. The end result with conventional orthopedics is disability, pain and suffering; the end result with regenerative orthopedics is a patient that is well, active, pain free and thankful.

Orthopedics Without A Knife

Orthopedics Without A Knife

Conclusion

There is a form of orthopedics without a knife: it is called regenerative orthopedics. The tools are prolotherapy for minor musculoskeletal problems. This is still scoffed at by some very conservatively minded physicians, but wrongly so. More severe injuries require more healing power and PRP prolotherapy is used for them. In the severe cases all of the healing power (minus the knife) is needed: this is where stem cell prolotherapy is utilized. With this the healing is initiated where it is needed using two types of stem cells that turn into the cell types that are required to do the repair. Research has shown in the past that the mesenchymal stem cells alone will not heal cartilage of joints very well, but if combined with bone marrow derived stem cells this is healed quite well and efficiently. Healing osteonecrosis and complicated lower neck and lower back problems borders to miraculous healing. Regenerative orthopedics is definitely something to remember should you get into trouble down the road. There are alternatives to the knife!

Nov
07
2015

Eat Your Avocado

Avocado is in the limelight, because it has been shown to be a super food with many positive effects on people’s health. It helps arthritis, is good for your vision, protects against cardiovascular disease, fights metabolic syndrome, helps in weight maintenance and even protects against some cancers. It contains healthy oils and many vitamins and minerals.

Avocado composition

80% of an avocado is fiber making it a valuable food to prevent colon cancer. Among the minerals it is noteworthy that avocados are rich in boron and potassium. In terms of vitamins it is rich in vitamin E (alpha-tocopherol), vitamin B6, folate, vitamin K and pantothenic acid. It does not contain cholesterol, but contains monounsaturated fat (oleic acid). Oleic acid is the compound in olive oil responsible for lowering your blood pressure. The oils in avocado contain 71% monounsaturated fatty acids, 13% polyunsaturated fatty acids and 16% saturated fatty acids. This mix promotes healthy blood lipids, but also helps in the absorption of fat-soluble vitamins and phytochemicals. In addition to all that avocados contain phytosterols, a number of carotenoids, non-carotenoid antioxidants, alphalinolenic acid (an omega-3 fatty acid) and glutathione.

Cardiovascular disease protection

The combination of fiber and folate in avocado help to reduce LDL cholesterol, which when oxidized can lead to hardening of arteries. The folate reduces homocysteine, which is a risk factor for heart disease. Phytosterols that are similar in structure to cholesterol compete with cholesterol absorption in the gut.

In a 2015 study several diets were compared with regard to LDL lowering potential, either a low fat diet, or two forms of medium fat diets, where one contained one avocado per day. The results were surprising: the low fat diet reduced LDL by 7.4 mg/dL while the avocado diet reduced LDL by 13.5 mg/dL.

The oils in avocados also seem to suppress the appetite center in the brain helping people to eat less and controlling obesity and diabetes.

Arthritis prevention

In a 2014 study hip osteoarthritis was examined for 3 years. An extract from avocados and soybeans was used and found to be protective of osteoarthritis. The anti-inflammatory components of avocado like omega-3 fatty acids, carotenoids, phytosterols and non-carotenoid antioxidants all work together in countering joint inflammation. Boron abundantly contained in avocado also was found to be essential for healthy joints.

Eye protection

Avocado has its own mixture of carotenoids, like alpha- and beta-carotene, lutein, zeaxanthin, neochrome, chrysanthemaxanthin and others. These are contained in the green pulp. They have anti-inflammatory properties. The fatty acid profile of avocados helps to absorb carotenoids, as they are fat-soluble. A two phase clinical study was done that showed that avocado added to salsa or to salad was leading to 5- to 15-fold increased absorption of the carotenoids in salsa and salad when compared to avocado-free salsa and salad.

This is an important observation that we should remember: always eat some avocado with any fruit or vegetable that contains carotenoids, as this will improve the absorption of the carotenoids tremendously.

Why is that so important for eye disease? In a 2008 study a total of 1802 women aged 50 to 79 years from Iowa, Wisconsin, and Oregon were followed who had intakes of lutein and zeaxanthin above the 78th percentile. They were compared to women below the 28th percentiles in the Women’s Health Initiative Observational Study with eye examinations in both groups. The eye specialists examined their eye lenses for nuclear cataracts. The surprising findings was that women with the highest quintile category of diet or serum levels of lutein and zeaxanthin had 32% less nuclear cataracts than women in the lowest quintile of lutein and zeaxanthin.

This shows that carotenoids of avocados have vision protective effects.

Metabolic syndrome and obesity

This 2013 study included 17,567 US adults and part of the National Health and Nutrition Examination Survey (NHANES) 2001-2008. Comparisons were made between avocado eaters and non-avocado consumers. Interestingly, avocado eaters had a much better overall food quality in their diet: more vegetables, fruit, fiber and less added sugar. Calorie and sodium intake were identical in the two groups. But body weight, body mass index and waist circumference were significantly lower in avocado eaters than in the non-avocado control group. The cardio protective HDL cholesterol was significantly higher in the avocado group. The odds ratio for developing metabolic syndrome, the change in metabolism due to obesity was 50% lower in avocado consumers than in non-consumers. All of this is good news for the consumer, if we eat some avocado.

Skin, beauty and anti-aging

We don’t like to develop too many wrinkles, as they are associated with aging. The oils of avocados have been used for some time in skin care products as they stimulate collagen production in the skin and reduce wrinkles. But when you eat avocados, the carotenoid substances (such as lutein and zeaxanthin) serve for skin protection, protecting you from UV light damage. In addition, vitamin E and glutathione, which are also contained in avocado help to scavenge free radicals; they would otherwise prematurely age and wrinkle the skin. The end result is that the development of wrinkles will be reduced, when you consume avocados. The beneficial effects on your blood vessels in combination with protecting your skin will age your body slower, a point that has been noted in the anti-aging literature.

Cancer blocking properties

In the following I will briefly review the findings of several cancer research groups, but this review is by no means complete.

a) Leukemia:

This 2015 study describes a new chemotherapeutic agent, derived from avocado that they named Avocatin B. Avocatin B is active against the difficult to treat acute myelogenous leukemia (AML). It works by targeting mitochondrial components of AML, but does not affect healthy leukocytes or leukocyte progenitor stem cells.

b) Colon and esophageal cancer:

The authors of this study from Iran describe four phytoextracts of avocado for treatment of patients with esophageal cancer and colon cancer. They noted that the phytoextracts have a much lower toxicity than standard chemotherapeutic agents and significantly slow growth of these cancers. They plan to use these phytoextracts as complementary treatments of esophageal and colon cancers.

c) Oral cancers: this paper describes that avocado extracts were shown to be successful in treating oral cancers.

d) Cancer prevention: In this paper it is discussed that the phytochemicals in avocados arrest cancer cells in their cell division cycle and lead to apoptosis, which is natural cell death. The authors believe that eating avocado regularly can help prevent a whole array of different cancers by this mechanism.

Eat Your Avocado

Eat Your Avocado

Conclusion

Avocados are a super food, which has many beneficial effects. Perhaps one of the outstanding effects is prevention of obesity and the metabolic syndrome as discussed. Women may want to eat it because of the beneficial effects on skin and beauty. We all should be interested in wanting to prevent heart attacks, strokes and cancer.

But who does not want to prevent cataract surgery and keep good vision until a ripe old age? It is possible by eating avocados. And would you not want to prevent osteoarthritis? Eat avocados and add some omega-3 fatty acid from distilled fish oil as well to get the full anti-inflammatory effect. Your joints will thank you and let you swiftly move wherever you want to go.

I thought you should know about the health benefits of eating avocados. They make a nice addition to your food, not only as guacamole, but in a wide variety of dishes: use a few slices on your salad, make a tasty dip, and get inspired by recipes that you can easily find on line.

Incoming search terms:

Sep
12
2015

Ageless Aging

We have been exposed to a lot of clichés about aging, which makes it more difficult to dispel rumors and to clearly focus on what can and what cannot postpone aging and the associated disabilities. Here I will attempt to summarize what is known about this topic.

The American Academy of Anti-Aging Medicine (also known as A4M) has published a book where all of this is discussed in detail (Ref.1). But there are yearly conferences as well in Las Vegas and other places where further details regarding anti-aging are discussed. Since 2009 I have been attending the conferences in Las Vegas regularly every year.

Based on this knowledge let me start by reviewing the tools of anti-aging that can be used to slow down the process of aging significantly.

  1. Mitochondria

At the center of anti-aging is the preservation and metabolic optimization of the mitochondria. Each of our cells contains little particles called mitochondria, which is where our energy metabolism takes place. Mitochondria function like mini-batteries.

The citric acid cycle builds up ATP, which is subsequently hydrolyzed into ADP and orthophosphate releasing energy for cell metabolism.

Old people who shuffle when they walk and have difficulties climbing stairs have lost significant amounts of mitochondria and simply run out of energy. The key to prevent this from happening is to preserve our mitochondria. We inherited them from our mother, because only the head of the sperm, which does not contain mitochondria entered the ovum when the egg cell that was destined to become you was fertilized. Subsequently the mitochondria from mother’s egg have provided all of the mitochondria in the cells of our body.

  1. Preserving mitochondria

There are supplements that specifically preserve mitochondria: PQQ (=Pyrroloquinoline quinone) helps mitochondria to multiply. A typical dose to take every day is 20 mg. Mitochondrial aging is slowed down by ubiquinol (=Co-Q-10, 400 mg per day is a dose that I recommend). Co-Q-10 repairs DNA damage to your mitochondria.

There are simple lifestyle changes that you can make: eat less calories as this will stimulate SIRT1 genes, which in turn stimulate your cell metabolism including the mitochondria.

Resveratrol, the supplement from red grape skin can also stimulate your mitochondria metabolism. 300 to 500 mg of trans-Resveratrol once daily is a good dose.

Build in regular exercise into your day – and I mean every day– as this will also stimulate your mitochondria to multiply similar to the effects of PQQ. Lipoic acid is an anti-oxidant that counters the slow-down of mitochondrial metabolism. I recommend 300 mg per day.

L-arginine is an amino acid that is a precursor of nitric oxide (NO). Red beet is a rich source of nitric oxide, which is directly released into your system. There are also commercial products for NO. This keeps the arteries open, prevents high blood pressure and also hardening of the arteries and has a direct effect on preserving mitochondria.

Researchers from the McKusick-Nathans Institute of Genetic Medicine of the Johns Hopkins University School of Medicine in Baltimore, MD found that mitochondrial DNA content varies according to age (less mitochondrial DNA in older age), sex (yes, women have more than men) and mitochondrial DNA; it even has an inverse relationship to frailty and a direct relationship to life expectancy. This paper was published in February of 2015.

Each mitochondrion has its own mitochondrial DNA contained in 2 to 10 small circular chromosomes that regulate the 37 genes necessary for normal mitochondrial function.

In multi ethnic groups it was apparent that mitochondrial DNA content was dictated by the age of a person.

Frailty was defined as a person who had aging symptoms including weakness, a lack of energy compared to the past, activity levels that were much lower than before and loss of weight. When persons with frailty as defined by these criteria were identified, they were found to have 9% less mitochondrial DNA than nonfrail study participants.

Another subgroup were white participants; when their bottom mitochondrial DNA content was compared to the top mitochondrial DNA content, the researchers found that frailty was 31% more common in the bottom DNA content group. This means that white people are more prone to frailty and they should take steps early on to prevent this from happening.

  1. Slowing down hardening of our arteries

It makes sense that young people who do not have signs of hardening of their arteries have better blood supply to their cells and thus supply their mitochondria with more oxygen and nutrients than frail, older people. The same is true for people who exercise regularly.

Vitamin D and vitamin K2 have been shown to lower calcium in the blood vessels and to retain calcium in the bone preventing osteoporosis. This is particularly useful in postmenopausal women. This October 2014 publication mentions that apart from vitamin D and vitamin K2 resveratrol and inositol are additional factors helping to prevent heart disease and osteoporosis.

This September 2013 publication confirms that a deficiency for vitamin K2 is common in the general population. This deficiency leads to osteoporosis and calcification of the arterial wall and causes heart attacks, strokes and bone fractures. Supplementation with vitamin K2 at 200 micrograms per day every day is recommended to prevent this from occurring.

  1. Sugar and starchy foods

You need to understand that starchy foods equal sugar, once digested. As a result a refined cereal breakfast=sugar, pasta=sugar, bread=sugar, donuts=sugar, potatoes=sugar and so on. It has to do with the glycemic load. When you cut out sugar and starchy foods (meaning that the glycemic index of the foods you eat is below 50) you will shed 30 to 50 pounds of weight within 3 to 5 months, if you are overweight or obese. You will feel a lot more energy. Your blood vessels will be cleaned out as the oxidized LDL cholesterol will disappear and the HDL cholesterol will mop up what cholesterol deposits were there before.

It is certainly good for you, if you are not into the sugar and candy stuff, but the seemingly harmless pizza and all the other starchy foods mentioned above are of concern as well. All of the high -glycemic carbs stimulate the pancreas to produce insulin. This in turn produces inflammation in tissues including the brain. Alzheimer’s disease is one of the complications of this.

Where does this leave us? For decades we have been told that saturated fats and cholesterol in our diet were the culprits and we replaced them with sugar that is part of a low-fat diet. We need to pay attention to the glycemic index and cut out high glycemic foods. However, it is OK to eat some carbs from the medium glycemic food list and most of our carbs from the low glycemic food list. With regard to fat it is important to consume only the healthy fats like olive oil, coconut oil and omega-3 fatty acids. As you make these adjustments to your life style you will also prevent many cancers, as you normalize the body’s metabolism and help prevent chronic inflammation, which can cause arthritis and cancer. Finally, pay attention to stress management. The body and the mind work together. Uncontrolled stress leads to heart attacks and strokes.

  1. Cut down on processed foods

Processed foods contain the wrong type of vegetable oils that are composed of omega-6 fatty acids. This disbalances the ratio of omega-6 fatty acid versus omega-3 fatty acids. This is typical for all the processed foods, but also fast food places in the industrialized world. The consequence of this disbalance is the formation of arachidonic acid and inflammation of tissues. This causes high blood pressure from inflammation of the arteries, arthritis from inflammation in the joints and can irritate the immune system to the point of causing autoimmune diseases. The end result after decades of exposure to a surplus of omega-6 fatty acids are disabilities from end stage arthritis, as well as heart attacks and strokes from inflammation of the arteries due to the hardening of the arteries.

The remedy for this is to cut out all processed food and stick to the basics of preparing your own food from healthy ingredients with no food preservatives.

Use olive oil for salads and coconut oil for cooking. Take omega-3 supplements to restore the omega-6/omega-3 fatty acid balance.

  1. Replace hormones with bioidentical ones

When I watch postmenopausal women, many look prematurely aged with sagging skin in their faces. Had they replaced their missing hormones when they entered menopause, the bioidentical hormones used for replacement therapy would have helped their skin to remain younger looking, hardening of the arteries would have been postponed and osteoporosis in the bones would also have been prevented.

With men it is now known that testosterone is vital for prevention of prostate cancer, but it is also important to prevent heart attacks, strokes and dementia as they age.

I would recommend that you see a naturopath or an anti-aging physician to have your hormones checked and if necessary start replacement with bioidentical hormones.

Ageless Aging

Ageless Aging

Conclusion

Slowing down aging and avoiding disabilities from aging are now a possibility, if we manage our lives in a way that the biochemistry of our bodies remains the same and our mitochondria continue to function, even when we get older. I discussed the details of how to do that above. I have also written a book on the subject of anti-aging, which deals with these topics in more detail.

I hope that you incorporate at least some of these steps in your life to prevent suffering from disabilities as you age and to avoid premature aging.

References:

Ref.1: Ronald Klatz, MD, DO and Robert Goldman, MD, PhD, DO, FAASP, Executive Editors: “Encyclopedia of Clinical Anti-Aging Medicine & Regenerative Biomedical Technologies”. American Academy of Anti-Aging Medicine, Chicago, IL, USA, 2012.

Jul
31
2015

Two Is Better Than One: Omega-3 And Krill Oil

Omega-3 fatty acids have gotten a lot of limelight in the press; krill oil was kept more in the background by the media. But both omega-3 and krill oil are important for your health.

What can confuse you is the following paragraph that I picked up from Facebook:

“I cannot believe that in the last 7 days 3 Doctors have asked me what krill omega-3 is. One would think that those who look after our health would realize that the high levels of mercury in the regular omega-3 has reached dangerous levels. Krill oil is harvested from pristine waters of the Antarctic Ocean and tested to be free from harmful levels of mercury. If you have not heard of it, it is for brain, heart, joint and immune health.”

Clarification of what Omega-3 fatty acids are

Depending on where fish is within the ocean’s pecking order of feeding, the levels of mercury of the fish oil that contains omega-3 fatty acids will be higher or lower. Tuna, for instance is one of the predator fish on top of the line. They are large predator fish, and as a result, not a fish you want to eat as it has very high levels of mercury. Salmon on the other hand is lower in the line of predator fish. That’s why it is still recommended to eat salmon two or three times per week. Fish oil is pooled from various fish and then molecularly filtered through a special filter that removes heavy metals like mercury, cadmium and others. Knowing these facts, the Facebook text above may be accurate in stating, “regular omega 3 has reached dangerous levels”, but it is inaccurate for the molecularly filtered omega-3 fish oil, which is the only one I would recommend as a supplement. Having said that there are still significant differences in quality according to a report online that tested 51 common products in the US. The omega-3 fatty acids EPA and DHA are stored in the membranes of platelets and in circulating plasma triglycerides, which is useful for the functioning of the lining of our arteries. This is called endothelium and needs to be healthy to lower blood pressure and prevent hardening of the arteries. Omega-3-fatty acids support the cardiovascular system foremost and the brain secondarily.

Where does Krill oil come from?

Krill oil comes from tiny crustaceans called krill that provides additional benefits that are not found in fish oil alone. Although the initial concentration of raw krill oil has less mercury per milliliter than omega-3 fatty acid fish oil, it still needs to be molecularly filtered to remove heavy metals. Also bear in mind, that the tiny crustaceans live in the same polluted ocean waters as other fish. It is a sad fact that our oceans are no longer pristine! The same is true for the Antarctic Ocean. After the filtering process both krill oil and omega-3 fatty acid fish oil are equal in their quality (free of mercury, other heavy metals, PCB and dioxins).

The omega-3 fatty acids of krill oil have an affinity to bind with phospholipids in red blood cells. This enables krill oil to cross the blood-brain barrier and get into the brain cells providing support for the brain. In this respect krill oil has an edge over omega-3 fatty acids to support the brain. But secondarily it is also good for your heart and the lining of the arteries.

Benefits of marine oils like krill and fish oil

It is best to think about krill oil and omega-3 fatty acids (fish oil) as complementary marine oils that have multiple beneficial effects on the body.

Studies have shown that arthritis and osteoarthritis are helped by krill oil, but also by fish oil. Similarly, heart attacks and strokes are prevented with both krill oil and omega-3 fatty acids. It appears that both oils reduce inflammation in the arteries that are associated with high blood pressure, diabetes, obesity and the metabolic syndrome in obese people. C-reactive protein measuring inflammation was reduced by krill oil up to 30% compared to placebo within 30 days. Patients with arthritis had 20% and more reduction in stiffness and pain.

Krill oil is well absorbed into the brain and can prevent age-related brain shrinkage, preserve cognitive function and memory, prevent dementia and also possibly depression.

Other health conditions improve on both krill oil and omega-3 fatty acids like osteoporosis (in combination with vitamin K2, vitamin D3 and calcium), a weak immune system, diabetes, high triglyceride levels and cholesterol problems. Both marine oils prevent LDL cholesterol from being oxidized, which helps to prevent atheroma formation and hardening of the arteries. This prevents heart attacks and strokes.

Fear mongering Facebook write-ups

In this context let me clarify the fear mongering Facebook write-up cited at the beginning of this blog. It is a misconception to think that krill oil is devoid of mercury. It is only so, if it was molecularly filtered, which removes all of the mercury and more, but it leaves the beneficial DHA and EPA (omega-3 fatty acids) intact. In the same vein omega-3 fatty acids from fish oil are initially more mercury containing, but after molecular filtration are entirely mercury free, the same as krill oil after molecular filtration. But the mix of omega-3 fatty acids is slightly different with krill oil being a bit richer in DHA and attaching to red blood cells easier while fish oil omega-3’s attach to triglycerides in the liquid phase of the blood, called plasma and also to platelet membranes. So neither krill oil or omega-3 fatty acids are better than the other; they are slightly different and that’s why you benefit from a mix of both. It would be a big mistake to follow the Facebook advice above and only take krill oil by blindly trusting the quotation. In my opinion it is simply a marketing plot to get you switched from fish oil to krill oil.

What combination of Krill oil and omega-3 fatty acid should I take?

Most trials with krill oil have been done with 300 mg of krill oil per day.  I take a dosage of one capsule per day of 300 mg. There are several manufacturers that produce similar products. I also take 3 capsules of omega-3 fatty acids twice per day. Each capsule has 647 mg of EPA and 253 mg of DHA, which translates into a daily dose of 3882 mg of EPA and 1518 mg of DHA. Again, there are several products from which you can choose. The reason I take a relatively high dose of fish oil is the fact that I come from a family background with severe arthritis that started in several relatives at an age of 50+. I have no sign of arthritis at age 70. It may be the result of taking these supplements and staying away from sugar and starchy foods. I need my joints to do ballroom and Latin dancing and I also need them to attend the gym regularly. Exercise by itself has been shown to prevent arthritis and prevent heart attacks and strokes. We need the benefit from all these things in combination: good nutrition, supplements and exercise.

Two Is Better Than One: Omega-3 And Krill Oil

Two Is Better Than One: Omega-3 And Krill Oil

Conclusion

Both krill oil and fish oil (omega-3 fatty acids) are needed as supplements to prevent arthritis, strokes, heart attacks, osteoporosis, diabetes, dementia, Alzheimer’s and inflammation. The key to a good krill oil or fish oil supplement is to buy the more expensive products that are molecularly distilled and therefore more concentrated, but also free of heavy metals and other contaminants. These supplements are only a small part of your overall anti-aging program that needs to include good nutrition (organic food), exercise, other supplements and if necessary bioidentical hormone replacement.

Reference: Dr. R. Schilling: “A Survivor’s Guide to Successful Aging“. Paperback through Amazon.com, 2014. This text explains the anti-aging program I follow and includes recipes composed by my wife for 1 week.

Apr
25
2015

Rejuvenate With Stem Cells

We all age; but can we rejuvenate with stem cells? There is a limit to detoxification, to eating organic food, to exercising, to the effects of vitamins and supplements and even to the effect of bioidentical hormone replacements. The limit comes from our telomeres and from stem cells that get depleted in our body as we age. Some researchers report that in regions where we suffer from a disease stem cells are even more depleted than in the rest of the body.

We do not have all the answers yet. We would like to know why our stem cells in the fatty tissue or in the bone marrow do not migrate on their own into an aching back or a sore shoulder. There are all the aches and pains associated with old age. So, why do our own stem cells not help us? They seem to be locked away in fatty tissue and in bone marrow.

At the 22nd Annual World Congress on Anti-Aging Medicine in Las Vegas (Dec. 10-14, 2014) I learnt that there is a group of stem cell experts in California with affiliates all over the US. They simply take stem cells from the fatty tissue and sometimes also from the bone marrow, isolate the stem cells through a stem cell separator and infuse the stem cell rich fraction (minus fatty and connective tissue) in a bit of saline solution back into the vein of the patient. When the stem cells are in the blood stream, they get activated by the growth factors that are present in blood and can now find where they are needed and start the healing process.

Studies have shown that when stem cells are in circulation in the blood, they are very sensitive to signals from tissues that indicate that there is an inflammatory process. This is why stem cells will repair arthritic changes. The can repair a torn meniscus, a rotator cuff tear in the shoulder or repair a weak immune system. The interesting observation is that stem cells from fatty tissue, also termed mesenchymal stem cells, are pluripotent. This means they can develop into cartilage building cells (chondrocytes) and build up cartilage; this is badly needed in a person with severe osteoarthritis. But stem cells are flexible: they can turn into meniscus cells in a knee with a torn meniscus. They also can repair the damage and relief the patient of the chronic pain. In a shoulder with a rotator cuff tear they can turn into a tough ligamentous material mending the tear.

Some data even indicates that circulating stem cells can repair vital organs like the brain, heart, liver, kidneys and bone marrow; these latter observations were mostly done in animal experiments, but human data is starting to be published in the medical literature.

So, let’s examine what has been found useful with regard to stem cells that are taken from your fatty tissue or your bone marrow and injected into one of your veins.

Here is a website from Arizona that I am only showing as a typical example (I have no conflict of interest and no commercial connections to this group) of what I described above.

With websites like this it is also important to read the disclaimer: “Even though our treatments are done using autologous cells, our Stem Cell Therapies are not approved by the FDA. Stem Cell Treatments are not a cure for any condition, disease or injury, nor a substitute for proper medical diagnosis and care…” Another website from La Quinta, CA describes the use of mesenchymal stem cells for regenerative therapies.

Stem cell treatments are in flux. There is a large body of knowledge that has accumulated showing that with proper technique and aseptic conditions it is a safe procedure. The FBA has been watching this. There are publications regarding the safety of procedures with adipose mesenchymal stem cells; here is one example.

The next step is to show in clinical trials that a certain procedure with stem cells is effective in treating a certain condition.

Below I did a literature review, which are only a few examples, but does not claim to be complete; it highlights some of the problems with stem cell treatments.

Stroke treatment with intravenous administration of bone marrow mononuclear stem cells

This study from India showed no statistical difference of stroke patients treated intravenously with bone marrow derived mononuclear stem cells (the experimental group) and the control group that did not receive such treatment. The investigators examined both groups with functional brain tests and performed PET scans to look at the healing of the brain lesions. Unfortunately the tests showed no statistical difference, but did show that the stem cell procedures were safe. It may be that the wrong stem cells were used (mononuclear bone marrow stem cells) when adipose derived mesenchymal stem cells may have done better. In stark contrast to the study from India is the stem cell treatment for a severe stroke in the former hockey player, Gordie Howe that has gone through the media recently. His procedure was done in Mexico. The stem cells were administered via a lumbar puncture approach as well as intravenously. As you can see from this case, stem cell treatment is even possible in patients who are in their mid 80’s with impressive results.

Parkinson’s disease

Here is a feasibility study from March 2014. A 71-year-old Asian man with progressive supranuclear palsy, an aggressive form of Parkinson’s disease was treated with adipose tissue-derived mesenchymal stem cells that were administered intravenously and intrathecally (to get stem cells into the cerebrospinal fluid that bathes the brain). A remarkable functional recovery took place.

Possible side-effects

This is a report of pulmonary embolism after administering intravenous adipose tissue-derived stem cell therapy. The blood clots in the lungs were treated with anticoagulant therapy. Repeat CT scans of his lungs showed later that the emboli were dissolved spontaneously. It is not clear whether this was a case where familial clotting problems pre-existed as a relative of this patient experienced a similar occurrence after stem cell therapy as well.

A case of chronic autoimmune thrombocytopenic purpura

A rare form of autoimmune disease exists where the body forms antibodies against platelets that help your blood to clot. Here is a paper from June 2009 that describes how a man with this disease was cured using adipose tissue-derived mesenchymal stem cells that were injected intravenously.

Renal transplant survival in type 1 diabetes patient

This case report from India shows that adipose tissue derived mesenchymal stem cells that were given at the time of a kidney transplant to treat end stage kidney disease. The treatment stabilized the condition of this patient after a kidney transplant. At the same time some of the mesenchymal stem cells differentiated into insulin producing cells, which made it much easier to control this patient’s diabetes. In this case stem cells were providing stability following an organ transplant (kidney) and some stem cells turned into insulin producing pancreatic cells.

Osteonecrosis of hip treated with adipose tissue derived MSC

In this study from South Korea dated January 2012 two cases of osteonecrosis of the hip, where the hipbone died (osteonecrosis) are described. The following stem cell protocol helped: The fraction that contained the stem cells (called stromal vascular fraction) was mixed with platelet rich plasma and hyaluronic acid. Using a long needle this mixture was injected into the affected hip joint. Conventional medicine has nothing to offer except a total hip replacement. But here are two cases that showed complete resolution of their pain, regained hip function completely, and healing could be documented with the help of MRI scans.

Treating heart attack patients with stem cells

Here is a paper from The Netherlands, published in June 2014 that describes the problems with stem cell treatment in humans. It points out that much has been learnt from animal experiments. The problem following a heart attack is that there is a massive inflammatory response in the infarcted heart muscle, which makes it difficult for stem cells to establish themselves in the injured heart muscle. However, stem cells have been shown to prevent the development of cardiomyopathy that follows a massive heart attack and often is the cause of death. More refinements are needed for successful treatments, such as the ideal timing of stem cell injections in relationship to the time of the heart attack, the best treatment approach and what number of stem cells to inject are all questions that still need to be answered.

MS model in mice shows promise with adipose mesenchymal stem cells

Experimental encephalitis in mice is used as a model for MS in humans. It helps to preselect potentially effective treatments for MS in humans. In this 2013 paper from Australia researchers used mesenchymal stem cells from adipose tissue and injected them intravenously. To their surprise the mesenchymal stem cells were able to penetrate the blood/brain barrier and end up in the myelin lesions inside the brain. In contrast, bone marrow derived stem cells were unable to do that. The researchers stated that adipose mesenchymal stem cells should be considered “as a cell therapeutic that may be used to treat MS patients”.

A group from Iran published this paper in February 2015 further emphasizes that mesenchymal stem cells would be a logical way to treat MS in humans.

Immunosenescence

As we get older the immune systems weakens because of a process called immunosenescence.

A research group from Austria published a paper in December 2011 that is typical for the thinking that mesenchymal stem cells from fatty tissue have properties that help the immune system to get stimulated. Based on this human data it should be possible to stimulate the immune system by giving stem cells from the fatty tissue to the same person intravenously. This publication shows that this process, which would benefit people above the age of 50 or 60 when the immune system gets weaker, will indeed stimulate the immune system. However, at this point we do not have the data of large clinical trials where this would have been done with measurements of the immune function before and on several occasions after stem cell injection to get a feeling for how long the effect would last. We also do not know whether this procedure is associated with longevity.

Rejuvenate With Stem Cells

Rejuvenate With Stem Cells

Conclusion

Stem cell therapy is definitely coming and many applications are already established as I discussed in a prior blog. It is only recently that physicians are no longer worried about creating tumors with stem cell transfer. Now we are in a phase where various stem cell transfer methods (intravenous, intrathecal, interstitial) are being tested as a treatment for various illnesses. It looks like stem cells from fatty tissue may soon be used intravenously, but I have not seen any such trials when checked on PubMed. The activation of stem cells by laser light has only been mentioned sparingly in the literature. This combination (laser activated, intravenous mesenchymal injection) has the potential for being useful for a multitude of chronic illnesses like fibromyalgia, MS, generalized arthritis, just to mention a few. Mesenchymal stem cells are anti-inflammatory, and they can mend defects without leaving scars.

Apr
15
2015

Avoid Brain Atrophy

When a 24-year old football player (Chris Borland) suddenly decides to quit his active sports career, because he wants to plan for a disability-free long life without brain atrophy, the world listens. Chris did his research about traumatic brain injuries, which can lead to degenerative brain disease or chronic traumatic encephalopathy (CTE). Trauma to the brain is just one cause of brain shrinkage (medically termed “brain atrophy”).

I like to take a broader overview of the topic of brain atrophy, which looks at all of the factors that can lead to brain shrinkage including physical injuries to the brain from blows to the head.

The vast majority of cases of brain shrinkage do not come from physical injuries, but rather from medical illnesses. Many of them including many sports injuries are preventable. This is the topic of my blog today.

Brain atrophy means a loss of brain cells, which causes a smaller brain. An MRI scan (around 800 to 1000$) will give information about the brain.The most sophisticated tool to depict the functioning of the brain may be the SPECT scan (ranging from 2000 to 2500$).

What causes brain atrophy?

It is important to realize that a multitude of different factors can cause the same end result – brain atrophy. All of these factors work together causing brain atrophy and the more factors are at play the worse the outcome. So, let’s review the various known causes of brain atrophy.

Diabetes

It has been known for a long time that diabetics can develop brain atrophy and dementia when their blood sugars are not well controlled. This leads to the formation of advanced glycation end-products (AGEs).

Insulin and IGF-1, a factor produced by the liver in response to human growth hormone have been found to counter the development of brain atrophy in diabetics.

The key in patients with diabetes is a close control of blood sugars, best measured as the hemoglobin A1C blood test. At the 22nd Annual World Congress on Anti-Aging Medicine In Las Vegas (Dec. 10-14, 2014) Dr. Theodore Piliszek stated that the new normal range for hemoglobin A1C is 3.8 to 4.9%, quite a bit lower than the normally recommended values. Accepting the old values that proclaim levels of 5.5. as normal automatically puts you in a higher risk of developing brain atrophy and dementia.

Cardiovascular disease

What is good for the heart is good for the brain. That is what Dr. Perlmutter stated in his book (Ref.1). But the reverse is also true: if your cardiovascular system is sick, your brain gets sick!

Here is a full-text article that describes how intimately connected heart function and brain function is.

Cardiovascular disease is a broad term and includes atrial fibrillation, blood clots in the coronary arteries or brain vessels (medically called “thrombotic events”), high and low blood pressure, heart failure, heart valve defects, low cardiac output, inflammation in the blood and a genetic marker, called Apo E, which is commonly associated with Alzheimer’s disease.

The end result of any of these conditions will cause brain atrophy. Once a problem is identified, it is important that the patient is seeing the appropriate specialist who will take care of the risk factor in order to prevent brain atrophy.

Vitamin B deficiency

Some people are born with a certain degree of a methylation defect, a deficiency of certain enzymes, which prevents methylation of brain hormones and other metabolic products. This can lead to depression, schizophrenia, memory loss and you guessed right: brain atrophy, which manifests itself as Alzheimer’s disease or dementia.

By using the proper nutrients with high enough supplements of vitamin B2, B6 and B12 this biochemical process can be restored and brain atrophy can be prevented. SAMe is also a useful supplement that supports methylation and a normal brain metabolism. Ref.2 explains methylation defects in more detail.

Obesity

The question is whether the “brain shrinks as the waist expands”. The answer is a clear “yes”. Researchers have found that the grey matter (with which we think) in the frontal lobes of the brain shrink in obese people of all ages. The researchers found further that the grey matter shrunk in the temporal and parietal parts of the brain of people in middle and old age.

The key here is to cut out refined carbs (sweetened sodas, pasta, bread, sugar in any form), as they are the ones that cause obesity. This occurs by the liver metabolizing sugar and turning it into fat that is stored. Just by cutting out sugar and starchy foods both my wife and I lost 50 pounds each in 2001. It can be done, but it takes a bit of will power.

The terminology may be confusing here: it is really sugar that causes brain atrophy via causing obesity and damage to the blood vessels.

Smoking and alcoholic beverages

Smoking leads to brain atrophy by damaging the blood vessels that are supposed to supply the brain with nutrients. If blood vessels close off or hardening of the arteries reduces the blood flow to the brain, brain cells die and brain atrophy develops.

Smoking also robs the body of vitamins, which slows down the brain cell function.

Alcohol is a nerve cell poison; it causes brain atrophy by directly damaging the brain cells (grey matter).

The results are memory loss, poor judgment, problems planning one’s future, loss of control with regard to emotions. This can lead to violent behavior and problems with regard to inter-personal relationships.

Genetic factors

ApoE4 gene variant, which causes inherited Alzheimer’s disease, causes a change of brain metabolism with deposits of a glue-like substance in the brain that damages nerve connections resulting in memory loss.

Researchers believe that ApoE4 is implicated in 20 to 25% of all Alzheimer’s cases.

Despite this apparent negative story, there is hope by radically changing one’s diet and taking supplements. Not every patient with one or two doses (alleles) of ApoE4 comes down with Alzheimer’s.

Avoid Brain Atrophy

Avoid Brain Atrophy

What can you do to prevent brain atrophy?

Supplements: Take regular B complex vitamins (particularly B2, B3, B6, folic acid, B12), vitamin E and C, carnosine, acetyl-L-carnitine, boron, ginger, coenzyme Q-10 (or CoQ-10), curcumin, vinpocetine, zinc, grape seed extract, blueberry extract, Ashwaganda, glyceryl-phosphoryl-choline, SAMe, huperzine A and DMAE. All of these have been found to support brain function and often restore memory function. Unfortunately regular anti-Alzheimer’s medications are not keeping their promise and on average just delay Alzheimer’s by 3 to 6 months. For details how these supplements work see this link.

Omega-3 fatty acids including DHA: These essential fatty acids from fish oil are very useful as they are anti-inflammatory and help support the normal brain metabolism, particularly DHA. In a Feb. 2015 US study from the Rhode Island Hospital 193 Alzheimer’s patients, 397 individuals with mild cognitive impairment and 229 normal individuals were followed for 5 years with MRI scans and cognitive tests every 6 months. 117 subjects were taking fish oil on a regular basis. The study showed a decline in gray matter in those who did not take fish oil and in carriers of the apolipoprotein E4 gene (a gene liked with Alzheimer’s disease). The gray matter on the MRI scans and brain function measure with cognitive function tests were much better preserved in those who took fish oil supplements.

Resveratrol: This powerful antioxidant is an anti-aging supplement. It is preventing heart disease, hardening of the arteries and helps preserve brain function by keeping the brain vessels from getting clogged up. DHA and omega-3-fatty acids are helping in that regard as well.

Eat nuts: Nuts are healthy (provided you are not allergic to them); but just because you are allergic to one kind does not mean you are allergic too all of them. Often a person allergic to hazelnuts will not be allergic to Macadamia nuts, cashew nuts or walnuts. Nuts contain a mixture of essential fatty acids, blood vessel friendly, saturated fatty acids and minerals that are all brain supportive.

Exercise regularly: Whoever moves and exercises keeps the heart healthy and whatever keeps the heart healthy keeps the brain healthy as stated before.

Stress management and sleep (avoid chronic overstimulation of your brain): In our hectic society everything has to be instant, the expectations of managers are high, the labor force is stressed. The fastest runner, the best player etc. is celebrated. The rest of us often feel like “underdogs”, if we allow this type of thinking to rule ourselves. Use yoga, self-hypnosis, meditation, religious mediation and prayer to counter some of the stress from everyday life. We need some stress to get us going, but we do not need “distress”. Dr. Hans Selye, the father of the general adaptation syndrome due to stress, gave a lecture about this topic in Hamilton, Ont. in 1977, which I attended. I vividly remember how he projected a picture of his skeleton showing bilateral hip replacements. He said that chronic stress could lead to arthritis. He had developed end stage arthritis in his hips and required total hip replacements on both sides. He wanted to illustrate that stress leads to physical consequences; it may be a heart attack in one person, a stroke in another, arthritis in a third. Constant overdrive has physical consequences.

Avoid sugar and starchy foods: I left this point as the last as it may be more difficult to understand. I started touching this topic under “obesity” above. An overload of refined carbs leads to an overstimulation of the pancreas pouring out insulin. Too much insulin (hyperinsulinemia) causes hormonal disbalance and leads to diabetes type 3, the more modern name for Alzheimer’s. All starch is broken down by amylase into sugar, so essentially you get a sugar rush from any starchy food as well. Too much sugar in the blood oxidizes LDL cholesterol, which leads to inflammation in the body. The consequence of this are the following conditions: hardening of the arteries, strokes, heart attacks, Alzheimer’s due to brain atrophy, arthritis, Parkinson’s disease and cancer. I have blogged about these topics in many separate blogs.

Conclusion

In this blog I have reviewed how brain atrophy develops. There are a multitude of factors that over a lifetime can lead to brain atrophy. Repetitive head trauma from contact sports is only one reason; poor nutrition with too much sugar and starch and missing essential fatty acids (omega-3/DHA) is another potential cause. Add to this a lack of exercise, too much stress, alcohol and smoking and you covered most of the causes. Studies have shown that even when you carry the ApoE4 gene trait, only 30% will express it as supplements can suppress the expression of it. The key is prevention. Preserve your brain cells, prevent brain atrophy!

References:

Ref. 1: David Perlmutter, MD: “Grain Brain. The Surprising Truth About Wheat, Carbs, And Sugar-Your Brain’s Silent Killers.” Little, Brown and Company, New York, 2013.

Ref.2: William J. Walsh, PhD: “Nutrient Power. Heal your biochemistry and heal your brain”. Skyhorse Publishing, 2014.

Apr
11
2015

Fish Oil, Your Best Supplement

There was a story in CNN last year describing the dramatic recovery of a youngster who was involved in a hit and run brain injury. The physicians involved in his care strongly recommended “to let him go”. His family did not give up on him and tried bioidentical progesterone cream first and finally fish oil in high doses, which lead to a successful recovery from this young man’s brain injury. Nine weeks after the accident the patient was transferred to the rehabilitation hospital, still unconscious. At that time the family increased the fish oil dosage to 20 grams (=20,000 mg) per day. Within two days the young man woke up from his coma and called his mother on a cell phone.

The benefits of fish oil

Fish oil is sold under various brand names. The high potency ones contain about 1400mg of fish oil in one soft gel. Each soft gel has 647mg EPA (Eicosapentaenoic acid, commonly known as omega-3 fatty acid) and 253 mg DHA (Docosahexaenoic acid) and other fatty acids. Any of these more potent fish oil preparations are molecularly distilled meaning that mercury, cadmium and PBA impurities have been removed from the product before it is passed on to consumers.

Fish oil boosts your memory, it helps brain cells to function better. EPA is more beneficial for the lining of arteries and prevents heart attacks and strokes. The DHA component of fish oil is the building block of brain cells, and likely it was DHA that brought the young man with the hit and run accident back to consciousness.

Fish oil also has anti-inflammatory properties, which is important for arthritis and prevention of heart attacks.

Everyday supplementation with fish oil

For persons with no arthritis and health risks a good fish oil supplement dose would be 1 or 2 of the higher potency fish oil capsules per day. This will help to prevent inflammation. The American Heart Association recommends to consume salmon two times per week, which will also give you a good dose of fish oil.

People with arthritis need more fish oil

As this link shows people with arthritis need more omega-3 fatty acids (EPA), namely 2.7 grams or more (=2700 mg or more) per day.

This would mean 5 capsules of the high potency supplement I described above to bring the total EPA to just above 3000 mg per day. People who have arthritis have so much more inflammation in their body that they need this higher amount of fish oil to get the condition under control. When you start fish oil supplements for arthritis it takes about 2 to 3 months for the fish oil to work before the inflammation is under control. So be patient.

Fat metabolism

When it comes to the metabolism of fatty acids, it is important to know the ratio of omega-6 to omega-3 fatty acids that we take in. For instance, there are a lot of omega-3 fatty acids in fish and seafood. On the other hand there is more omega-6 fatty aid in chicken and processed meat. Omega-6 fatty acid gets metabolized into arachidonic acid that causes inflammation. Most processed foods have too much omega-6 fatty acids in them. Here is a hint: when we consume more omega-3 fatty acids by increasing our fish oil supplementation, we counterbalance the omega-6 to omega-3 ratio. This will slow down aging, will control inflammation in the body and will prevent disabilities.

Side effects of fish oil

  1. Be aware that there is a difference between “fish oil” and “cod liver oil” or “halibut liver oil”. Cod liver and halibut liver oil has vitamin A in it; so avoid these formulations as this could lead to toxic levels of vitamin A.
  2. Fish oil is generally safe; there may be a mildly upset stomach at higher dosages, which is harmless and the dosage can be reduced until the stomach accepts it.
  3. Fish oil tends to thin the blood and theoretically there may be a problem when a person takes aspirin or blood thinners. Discuss this with the doctor. Patients with atrial fibrillation on blood thinners should discuss with their doctor whether it is safe for them to take fish oil supplements.
  4. Patients on platelet inhibitors (ASA and others) should first clear with their physician whether it is safe. The FDA did a review on this and stated that theoretically there could be interference in these situations, but practically no case was found that would have substantiated this.
  5. The cytochrome P450 pathway in the liver, which is used to eliminate antidepressants, erythromycin and many acid suppressing drugs (cimetidine, ranitidine) etc. is not interfering with the elimination of fish oil. The FDA confirmed this. This means that you will not have to fear that you overdose with fish oil because of drug interactions in the liver.

Fish oil supplementation in diabetes and heart disease

Many studies have shown that fish oil improves the control of diabetes, improves heart disease based on narrowing of coronary arteries and lowers blood pressure. It does so because of the anti-inflammatory effect of fish oil; this improves endothelial functioning, which leads to more nitric oxide production and lowering of high blood pressure. Patients find that they do not need as much insulin some time after starting fish oil supplementation, and their blood sugar is better controlled. They also get more energy, which may help to motivate them to engage in regular exercise, which in turn helps improve diabetes, prevents cardiovascular disease and Alzheimer’s disease.

Fish oil to prevent Alzheimer’s disease

Apart from other factors mentioned in this link the regular consumption of fish and fish oil will help improve memory and Alzheimer’s in general. It is the DHA contained in fish oil that is needed by the brain and the omega-3 fatty acids in fish oil help keep the cardiovascular system healthy.

A study in the medical journal Alzheimer’s and Dementia from June 14, 2014 followed 193 older men and women with Alzheimer’s patients for 5 years. Every half-year they had a magnetic resonance imaging study (MRI scan) of the brain and neuropsychological testing. 117 subjects used fish oil supplements throughout the study. They were the ones who maintained their brain volume and in particular the hippocampus area, which is important for memory. They also preserved their brain function compared to those subjects who did not consume fish oil. They showed shrinkage of the brain and a decrease in size of the hippocampus as well as poor brain function in neuropsychological testing. Patients who were carriers of the apolipoprotein E4 gene did not show the protective effect with fish oil.

Fish Oil, Your Best Supplement

Fish Oil, Your Best Supplement

Conclusion

Consumption of fish and supplementation with fish oil capsules is a valuable adjunct to all of the other health measures you can take to preserve brain and heart function like regular exercise and consumption of a Mediterranean diet. Take a supplement, which is higher dosed and is molecularly distilled (also called pharmaceutically pure). This way you will get all the health benefits, and you will avoid exposure to toxins from the ocean, which are not eliminated in the less potent, non-purified and cheaper fish oils.

Apr
04
2015

Stop Suffering From Arthritis

Arthritis is an illness of the joints, mostly in older people (osteoarthritis or degenerative arthritis). However, a subgroup of younger patients can also develop a severe form of arthritis, called rheumatoid arthritis where autoimmune antibodies play more of a role.

In the 1950’s Dan Dale Alexander wrote a book called “Arthritis and common sense”. The medical establishment did not accept that simple remedy and Dan Dale Alexander was classified as a “quack”. However, Dr. Mirkin describes a study from Berlin that later confirmed that Dan Dale Alexander’s observation was correct: an emulsion made by shaking orange juice with cod liver oil and taken three times per day on an empty stomach would indeed improve osteoarthritis.

In 1964, still being a medical student I suggested to my future mother-in-law to give Dan Dale Alexander’s book about arthritis a try. Despite the well-established osteoarthritic condition in her left knee the arthritis vanished within 6 months and stayed controlled. I could not explain to her why this remedy worked, as higher doses of omega-3 fatty acids and higher doses of vitamin C were not yet known to be of value for arthritis.

This all changed with the advent of orthomolecular medicine (Ref.1). On page 76 of this book Dr. Frederick Klenner describes that ascorbic acid (vitamin C) at mega doses of at least 10,000 mg daily, but better even between 15,000 and 25,000 mg daily does have healing effects for arthritis. He stated further that repair of collagenous tissue (the joint surfaces) would require adequate ascorbic acid. On page 240 of Ref.1 Dr. Abram Hoffer, the founder of modern orthomolecular medicine reviewed the history of the use of vitamins in higher doses, particularly the use of vitamin B3 (niacin). He also mentioned that Dr. William Kaufman had used mega doses of vitamin B3 for arthritis as far back as 1950.

Overview of arthritis

Dr. Hoffer explains in Ref.2 that arthritis belongs into a group of diseases that are related to faulty nutrition, which in turn lead to vitamin and mineral deficiencies and a pandeficiency disease. Other diseases that belong to that group are cardiovascular disease, multiple sclerosis, cancer, diabetes, schizophrenia, mood disorders, alcoholism and autism. Contributing factors can be poor diets with overemphasis on refined and processed foods and consumption of sugar, allergies, diseases of the gastrointestinal tract and viral infections. Arthritis belongs into this group of illnesses as well. Niacin, vitamin B6 and zinc have been found useful to treat arthritis, but other vitamins and minerals are also needed. Here is a list of what Dr. Hoffer would suggest to use (Ref. 2):

1. Vitamin B3 from 100 mg to several thousand mg three times daily following meals. With niacin there can be skin flushing, which often goes away after the body gets used to the higher doses; but niacinamide could be used instead by those who are bothered by the flushing.

2. B complex: this contains each of the major B vitamins including vitamin B6 (pyridoxine). Take 100 mg once per day with a meal. Vitamin B6 may be needed up to 500 mg per day or more.

3. Vitamin C should be taken between 500 mg and several thousand mg three times per day after meals.

4. Vitamin D3: 4000 IU per day in the summer months. In the winter months particularly populations who live far north require 6000 IU per day.

5. Vitamin B1 (thiamine): alcoholics and very high sugar consumers need thiamine at 100 to 500 mg three times per day.

6. Folic acid at mega doses (prescription needed) works as an antidepressant, which requires 25 to 50 mg. To lower homocysteine levels lower doses of folic acid are sufficient.

7. Vitamin E: usually 400 IU to 800 daily. Muscle wasting diseases, Huntington’s disease and amyotrophic lateral sclerosis (ALS) require much higher doses up to 4000 IU per day.

8. Essential fatty acids (omega-3): It is strongly recommended to use a molecularly distilled product, which is free of mercury and PBC’s at 1000 mg three times daily following meals.

9. Selenium: The required dosage is 200 to 600 micrograms once daily (with any meal). In areas where selenium is deficient, this is particularly important.

10. Zinc: 50 mg of zinc citrate or 220 mg of zinc sulfate once per day with a meal.

11. Calcium and magnesium: Dr. Hoffer suggests 1000 mg of calcium with 500 mg of magnesium, although many experts now say that 1000 mg of calcium with 1000 mg of magnesium may be better.

Dr. Hoffer pointed out that this program is compatible with any medication and is non-toxic.

Thoughts on treating arthritis

 1. Conventional methods

The conventional approach to treatment of arthritis consists of anti-inflammatory medications like ANSAIDs. Unfortunately they have side effects like causing kidney damage after several years of use. Also, NSAIDs can lead to gastric bleeding from gastric erosions, which may require blood transfusions. Physiotherapy with reactivation and swimming have been found to be useful. Electro acupuncture can help for pain control.

2. Diet changes, multivitamins and minerals

As arthritis is found mostly in civilized nations, dietary factors have long been suspected to be of importance. Dr. Hoffer pointed out that arthritis is a pandeficiency disease meaning that overconsumption of sugar and processed foods has lead to multiple vitamin and mineral deficits that interfere with the cartilage metabolism leading to premature breakdown of cartilage and causing inflammation. It is not good enough to just take the supplements listed above; this needs to be combined with a fundamental change in diet. Cut out sugar and starchy foods. Return to homemade foods. Keep it simple with lots of vegetables, salads and organic meats. Now that you are starting to turn around your metabolism by a sensible diet the supplements listed above have a chance to work.

You will notice that Dan Dale Alexander’s idea of omega-3 fatty acids and vitamin C (from the freshly pressed orange juice) is contained in the list of supplements above. Dr. Klenner’s mega doses of vitamin C are also listed and Dr. Kaufman’s mega doses of vitamin B3 is contained in this list as well.

This list may not have been formally researched with controlled clinical trials, because the food industry and the makers of NSAIDs (Big Pharma) have no interest in this. But thousands of patients have been empirically treated with this regimen and a network of orthomolecular physicians has established that this regimen works to control the inflammation of arthritis and at the same time has no toxic side-effects.

 3.Laser, platelet rich plasma (PRP) and stem cells

Blue and green lasers have anti-inflammatory properties and are suitable for interstitial and intra articular laser treatments of arthritis. Dr. Weber has extensive experience with this treatment modality in Germany. I have discussed this in another blog.

However, prolotherapy, PRP and stem cell treatments are also an option for more severe cases of arthritis, particularly in arthritis of the knees, which can avoid total knee replacement surgery.

Stop Suffering From Arthritis

Stop Suffering From Arthritis

Conclusion

I met Dr. Hoffer in the early 1980’s during a meeting in Vancouver, BC when he wanted to establish a local orthomolecular division for British Columbia. Although I found the ideas fascinating, I felt that the College of Physicians and Surgeons (the regulatory body for physicians in BC) would scrutinize the practice of any orthomolecular member. At that time I would risk losing my license to practice medicine, which I just had received in 1978. So I decided not to join. Interestingly enough later in the 1980’s a member of the orthomolecular society of BC lost his license because of the use of mega doses of intravenous vitamin C. At this time the College considered these infusions useless or hazardous. Nowadays, any naturopathic and orthomolecular physician uses these intravenous vitamin C treatments as standard therapies. It shows how times have changed.

What has not changed is the food industry that undermines our health every day with hidden sugar contained in processed foods. In social functions it is customary to have a drink or two, if not more, which uses up our thiamine faster than we can replace it. Pandeficiency disease is alive and well as it was many years ago. It is in front of our eyes, but can we see it? Depending on what your eating habits are, do you need to make changes in your diet and perhaps take some or all of the ingredients of the multivitamin and mineral list above? Start by adopting a Mediterranean type diet, then add some of the supplements listed above. It is time to take a thorough look at natural treatment modalities against arthritis in the interest of preserving your health!

References:

Ref. 1: Andrew W. Saul, Ph.D.: “The Orthomolecular Treatment of Chronic Disease. 65 Experts on Therapeutic and Preventative Nutrition”, Basic Health Publications, Laguna Beach, CA, 2014.

Ref. 2: Chapter in Ref. 1 by Dr. Hoffer: “Pandeficiency Disease”, pages 24-30 (2014).