Jan
13
2018

Immune Support For Cancer Patients

Immune support for cancer patients is necessary when their platelets are decreasing from chemotherapy. Dr. John L. Hall gave a talk at the 25th Annual World Congress on Anti-Aging Medicine in Las Vegas, Dec. 14-16, 2017. He pointed out that when cancer patients receive chemotherapy their platelet counts in the blood decline. Dr. Hall participated in a 2010 study that investigated the use of RNA fragments to protect stem cells in the bone marrow from chemotherapy. The study showed how  fragments coming from E.coli protected patients’ bone marrow cells. This immune support for cancer patients allowed physicians to carry on with regular dosing of chemotherapy treatments for the patients’ cancer. There was no dosage reduction necessary and no interruption of the treatment schedule. The optimal dose was 80mg sublingually of RNA derived from E. coli, and patients self-administered the dosage every other day.

Low platelets mean bleeding

Normally patients would bleed or bruise easily when they received chemotherapy without protection by RNA fragments. There would be frequent nosebleeds, bleeding in the gums or in the mouth. Patients would also have blood in urine and get petechia on their skin.

Consequences of low platelet count on cancer patients

There are several consequences for cancer patients, when their platelets are low with chemotherapy.

  • Patients with low platelets have fatigue
  • They experience limitations with regard to physical function
  • When platelets are low, patients need platelet perfusions
  • There is compromise of their cancer treatment because chemotherapy needs adjustment of  or the dosage, or the therapist needs to postpone further treatment.
  • Their survival rates are lower due to cancellation of chemotherapy treatments
  • More medical resources are necessary because of platelet transfusions

How do RNA fragments work?

RNA fragments act as primers triggering DNA synthesis in bone marrow stem cells. Fragmented RNA is also protective of bone marrow cells when the patient receives chemotherapy. In animal experiments, where toxic chemotherapy was given, fragmented RNA allowed these animals to survive. This prompted oncologists to introduce this treatment modality into end stage cancer patients who are receiving chemotherapy. Results were stunning. The patients from age 18 to 80 tolerated the RNA fragments well. They were able under the influence of the RNA fragments to continue with their regular chemotherapy to completion of the therapeutic course. When laboratory tests measured platelets, the results were normal. The investigators concluded that the RNA fragments protected the bone marrow stem cells of platelets.

The tumors in this trial involved pancreatic cancer, head and neck cancer and cancer of the breast. In addition physicians also treated colon cancer, esophageal cancer and lung cancer .

More details about RNA fragment therapy in cancer patients requiring chemotherapy

Cancer patients who had no protection by RNA fragments had platelet levels that became lower and lower with every chemotherapy treatment cycle. Some patients never returned to normal platelet levels even once the chemotherapy stopped. Other cancer patients’ platelets took month before they returned to normal. Patients in this group either needed to either reduce  their chemotherapy dosage or put treatments on hold. Alternatively their treatment stopped prematurely.

In contrast patients whose bone marrow received protection by RNA fragment therapy had stable platelet levels. Their platelet levels recovered quickly to normal after each cycle of chemotherapy. No unplanned chemotherapy reduction was necessary and no platelet transfusions were required. All the patients were able to complete the treatment plan.

The physicians also observed that with RNA fragment therapy the peak platelet counts were still in the normal range despite chemotherapy. When patients recovered from the chemotherapy effect the platelets stayed in the normal range.

Insulin potentiation therapy

Research has shown that cancer cells have more insulin receptors than normal cells. Physicians used this fact  with a form of chemotherapy where the patient receives small doses of insulin first. Following that the patient can receive lower doses of chemotherapy. Dr. Donato Perez Garcia MD is the inventor of the insulin potentiation therapy (IPT). With this treatment the patient can receive lower than normal chemotherapeutic agents , which reduces the toxic side effects of chemotherapy. Unfortunately the side effect of the lower dose of chemotherapy still hits the bone marrow. As a result the platelets are dangerously low. Dr. Hall mentioned that RNA fragments are also effective with insulin potentiation therapy. This keeps the platelets in the normal range and patients can complete the course of insulin potentiation therapy.

More background about the insulin potentiation therapy

Dr. Robert Baratz has reviewed the merits of IPT thoroughly. He came to the conclusion that the so-called research about the effectiveness regarding IPT has not been done properly. In his opinion it is not proven that less chemotherapy is required when pretreatment with insulin has been done. There are also dangers that connect with insulin therapy. If the insulin dosage is too high blood sugar will go into dangerously low levels. The FDA has never accepted that the IPT procedure would be superior to standard chemotherapy. However, regardless of the chemotherapy dosage these chemicals are bone marrow toxic. Particularly the toxic effect on stem cells of platelets will cause diminished platelet counts in the blood with both procedures. In both cases RNA fragment therapy will overcome the toxic effect on the bone marrow stem cells.

Immune Support For Cancer Patients

Immune Support For Cancer Patients

Conclusion

Bone marrow suppression by chemotherapy has been a limiting factor for many years prior to the detection of RNA fragment therapy (RFT). RNA for RFT is derived from E. coli cultures. RNA fragments act as primers triggering DNA synthesis in bone marrow stem cells. This leads to the production of platelets that protect the patients from the toxic effects of chemotherapy on bone marrow. RFT allows the patient to receive treatment with chemotherapy without having to worry about bone marrow toxicity. No chemotherapy dose reduction is necessary and no platelet transfusions are needed. RFT should be a regular accompaniment to chemotherapy treatments for any cancer patient.

Dec
30
2017

Fasting Mimicking Diet

The fasting mimicking diet (FMD) was at the center of this year’s anti-aging conference in Las Vegas. This was the 25th Annual World Congress on Anti-Aging Medicine in Las Vegas, Dec. 14-16, 2017. Dr. Valter Longo, PhD reviewed some of the research he had done on longevity in yeast cells, worms and mice.

Fasting mimicking diet relevant in humans

Dr. Longo pointed out that this type of research has relevance in humans. If there was a cure for cancer, heart disease, stroke and diabetes, we would live 13 years longer. But if we stimulated longevity with this pulsed calorie restricted diet, we would live on average 30 years longer. There is a rare genetic abnormality where people are deficient for IGF-1, a growth factor produced in the liver. These genetically IGF-1 deficient people live longer and do not develop cancer. Observations like these and detailed mouse experiments inspired Dr. Longo to develop a new diet plan. Patients would receive a fasting mimicking diet on 5 days per month. The rest of the month would consist of a normal, balanced diet. 5 days of the month the person would consume a low 800-calorie diet. This is enough to ensure adherence to the diet, but low enough to lead to enormous metabolic changes including youth-preserving stem cell stimulation.

Clinical Application of fasting mimicking diet in cardiovascular health

Dr. Joel Kahn, Prof. of Medicine at the Wayne State University School of Medicine lectured later that day. He is also the Director at the Kahn Center for Cardiac Longevity. His talk was entitled “The Fast Track to Slow Cardiac Aging: Fasting &Targeted Nutrition”. He mentioned that a fasting mimicking diet was a powerful tool in cardiology to prevent heart attacks and hardening of arteries. He explained in detail the complex aging pathways that involve three components, IGF-1, mTOR and PKA. When lifestyle choices stimulate these genetic markers, accelerated aging is a consequence. But with the inhibition of those markers longevity can happen. He added that researchers looked at heart cells, where the same principles apply. Dr. Kahn pointed out that the basic research of Dr. Longo enables clinicians to see positive results in patients who follow caloric restriction for 5 days in a month on a regular basis.

How does the fasting mimicking diet work?

It is best to let one of the users of this diet explain how it works. Once per month you eat calorie-restricted food with only 800 calories per day and you follow this regimen for 5 days. Some patients receive 1100 calories for the first of these 5 days, if they have difficulties switching from normal food to the boxed food. Dt. Longo has developed boxed food, called ProLon (from L-Nutra). ProLon stands for “pro longevity”. Dr. Longo and Dr. LaValle mentioned at the conference that these prepared meals make it a lot easier for patients to stick to the low calorie diet. Three hundred dollars for the boxed food for 5 days are a stiff price, and this may well be out of reach for you.

Alternative way to make your own 800 calorie food at home

Nevertheless, this should not stop you. You can look at the ingredients online and copy the boxed food by creating your own balanced 800 calories per day food at home. It is true: you have to do some research! But counting calories and finding information about the caloric content of food on the Internet is not difficult. And preparing these very, basic, small and simple meals does not require a degree in nutrition. Here is another testimony from a user of the fasting mimicking diet.

Effect of the fasting mimicking diet on the metabolism

In the past it was thought that only ketogenic diets or periods of fasting would trigger longevity genes. But the basic research of Dr. Longo and others has shown that a low calorie diet for only 5 days can achieve the same thing. Longevity genes are activated; the negative aging pathways including IGF-1, mTOR and PKA are suppressed. The immune system gets activated from this. It also  leads to lowering of LDL cholesterol, triglycerides, blood pressure, insulin resistance, and diabetes improves. With the fasting mimicking diet the stomach sees some food, but the cells are fasting. According to Dr. Kahn this combination down regulates the body’s key nutrient-sensing pathways, which activates cellular regeneration and rejuvenation.

Clinical observations

Dr. Khan observed a high compliance rate with 3 cycles of the fasting mimicking diet. 94% of a group of patients were compliant over 3 months. Mild fatigue, mild headaches and mild weakness were present, but improved with each cycle. In addition to the above findings Dr. Khan found that there was weight loss, abdominal fat loss and waist circumference loss. There was also a reduction in IGF-1 levels, a reduction of the C-reactive protein and stimulation of stem cells.

Inflammation reduced, autoimmune diseases improved

The reduction of the C-reactive protein proves that semi-fasting reduces inflammation. The finding of stimulation of stem cells explains that regenerative processes can take place. Pain disappears, people report more energy and are generally feeling better.

There are other clinical findings. The positive effects from following the fasting mimicking diet last for several months. Also, when patients are on chemotherapy for cancer, the FMD will protect the healthy cells from the side effects of chemotherapy.

Dr. Kahn and Dr. LaValle noted that autoimmune disease responded to FMD. This was shown in both animal experiments using mice and in clinical case reports. Dr. LaValle described a 46-year old former Olympic athlete swimmer who had multiple sclerosis. After FMD she lost all of her muscle aches and cured her optic neuritis. This was something conventional medicine could not do for her.

Clinical applications of fasting mimicking diet

Here are some of the conditions that will respond to it.

  • Obesity, because of the weight loss effect
  • Diabetes: insulin resistance becomes lower and blood sugar levels drop.
  • High blood pressure reduced: many patients were able to reduce their medications or discontinue them
  • Prevention of heart attacks and strokes
  • Pain conditions will improve as all kinds of pain disappears, an effect for which at this point is no explanation
  • Autoimmune diseases like MS and rheumatoid arthritis improve, likely because of the effect of increased stem cell circulation
  • Prevention of heart attacks because of reduction of LDL, triglycerides and CRP
  • Cancer cure rates improved by protecting normal cells and bone marrow
  • Longevity improved in mice with a 3-fold increase of their life span. Telomere length in humans was increased. Increased stem cells will find defective areas that need repair. This effect will open up a new chapter in medicine.

Maintaining the achievements of the fasting mimicking diet

At this point the implications of this new approach to weight loss and metabolic rejuvenation can only be estimated.

Limiting calories for 5 days triggers a metabolic change, which is permanent. You can experience the full effect of this rejuvenating low calorie treatment. You can do it every month without having to fear vitamin or mineral deficiencies.

Here is another link to the website of Dr. Axe where the fasting mimicking diet is also recommended.

Fasting Mimicking Diet

Fasting Mimicking Diet

Conclusion

The 25th Annual World Congress on Anti-Aging Medicine in Las Vegas, Dec. 14-16, 2017 had a new theme. Several talks dealt with the fasting mimicking diet (FMD). It is a calorie-reduced diet for 5 days in a month that will reset your metabolism. But it will also stimulate your stem cells and can heal autoimmune diseases. If you need chemotherapy for cancer, it protects your bone marrow and improves cancer cure rates. The interesting thing is that the effects of this low calorie treatment persist permanently for many months.

With the help of this diet longevity has been shown in mice; there has been a threefold life expectancy boost. Smaller trials in humans have shown telomere lengthening and stem cell stimulation. It is too early to say what the long-term effects will be for humans. But you can treat yourself with the FMD for 5 days of every month on an ongoing basis. The other days of the month you are eating a normal diet. This will ensure that your metabolism stays in top shape.

A healthier and longer life

Practical applications for the FMD are huge. Patients with obesity, diabetes and pain conditions all benefit from this. High blood pressure drops. There will be prevention of heart attacks, and there is improvement in patients with autoimmune diseases. There is better cancer survival when on the FMD. Finally there is a strong possibility that you will live longer, but also stay healthier on this intermittent calorie restricted diet.

As Dr. LaValle said: it is “fasting with food”, and Dr. Kahn added: “Eat less, live more!”

More info:  Life extension through calorie restriction.

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Dec
16
2017

Mouth Flora And Your Health

You may not be aware that there is a connection between mouth flora and your health. But a recent publication provided proof that certain bacteria can cause esophageal cancer.

Esophageal cancer from certain bacteria

In a 2017 publication a study of mouth flora from 122,000 people showed an association to two types of esophagus cancer. The finding was that the periodontal pathogen Tannerella forsythia had as association with esophageal adenocarcinoma. This cancer is originating from the glandular tissue of the esophagus. In contrast, the bacterium Porphyromonas gingivalis caused another histological type of esophagus cancer, namely esophageal squamous cell carcinoma. This cancer originates from the inner lining of the esophagus. In addition, two mouth bacteria showed a relationship with reduced risk of causing esophageal adenocarcinoma. These two common mouth bacteria were the Neisseria species and the species Streptococcus pneumoniae.

Clinical example of a patient with esophageal cancer

To illustrate this with a clinical case description, here is an example from another publication. This is regarding a man who suffered from esophagus cancer. Initially doctors were puzzled about his diagnosis. He was a 53-year old patient with chronic alcoholic liver disease. He had an increased white blood cell count. A blood culture isolated Parvimonas micra, which is a pathogen normally only living in the mouth flora. A gastroscopy as part of the work-up showed an invasive squamous cell carcinoma of the esophagus. It had almost completely blocked the passage to the stomach. The pathological bacterium had accessed the blood circulation via the tumor mass in the lower esophagus. In the past physicians did not know about these associations.

Brush your teeth and floss every day

Brushing your teeth and flossing everyday controls the bacteria in your mouth. It prevents leakage of bacteria into your blood affecting your heart valves. Studies have shown that this also prevents heart attacks.

The literature on this is clear: chronic gingivitis has a link with bacteria in the mouth. They grow on the gums and can spread into your blood. They can then colonize in your heart valves and even in the lining of the arteries. This is particularly so in cases where there is already hardening of the arteries (arterial plaque). This can lead to heart valve disease like mitral valve disease. If this process occurs in coronary arteries, it can lead to heart attacks.This reminds you that there is a connection between mouth flora and your health.

Mouth wash

Many people feel they have “bad breath” and they need a mouthwash product. This is good marketing for companies that produce mouthwash. However, the truth is you need to be diligent about appointments with a dental hygienist, brush your teeth regularly and floss your teeth. If you suffer of constipation, increase your fiber intake and consider colonics. If you still think you have bad breath, use a natural mint product (read the ingredients). Why do I not like mouthwashes? They kill your mouth bacteria that are naturally there; this can disbalance the rest of your gut bacteria as you swallow part of the mouth flora when you eat or drink fluids. If you still want to use a mouthwash, use one without alcohol and without any carcinogens such as parabens. Also read this 2009 news item. It is as valid as it was then.

Chronic gingivitis and heart disease

It was not until about the mid 1990’s when it became apparent that gum infections and severe tooth decay could cause inflammation in the blood measurable by using the CRP marker (C-reactive protein). Dr. Joseph Muhlestein at the University of Utah demonstrated in 1996 that chronic gum infection could cause a heart attack. He isolated the bacterium Chlamydia pneumoniae in 79% of patients undergoing coronary bypass surgery, while samples from heart transplant patients isolated this bacterium in only about 5%. The new thinking was that bugs that multiply in diseased gums could migrate into the blood and cause platelets from the blood to clump together and block coronary arteries causing heart attacks. Also, restenosis after percutaneous coronary intervention was more likely to occur, if the pathogen count of gum bacteria in the blood was higher.

Infectious causes of endocarditis and heart attacks

Harvard University researchers have confirmed this. In the past physicians did not know that a bad tonsillitis with an aggressive bacterium, Streptococcus viridans, could cause subacute endocarditis, a dangerous infectious disease of the heart valves, which can be responsible for sudden death in younger persons. Neglected cavities in teeth can also harbor this bacterium. Another study in 2009 showed that two particular strains of bacteria in infected gums, Tannerella forsynthesis and Preventella intermedia, showed a connection with an increased risk for heart attacks; but it was more the overall burden of bacteria in the infected gums than the specific bacteria strains that mattered most.

See your dental hygienist regarding your mouth flora and your health

Given this background it is easier to understand that we need to take good care of our teeth and gums, if we want to maintain good health. As a start most people should see their dental hygienist (who usually works in a dentist’s office) twice a year. The dental hygienist will probe the depth of gingival pockets with a periodontal probe. A normal depth measures up to and including 3 mm. Deeper pockets than that usually indicate that the patient did not floss the teeth regularly. One needs to floss at least once per day, better twice per day, and it should not bleed after flossing (initially when a person flosses for the first time the gums tend to bleed a bit).

What the dental hygienist does

The hygienist will do scaling of plaques on the tooth enamel. If the hygienist detects any cavity, he or she will bring it to the attention of the dentist. At the end of the scaling procedure the hygienist will apply fluoride, which puts a coating on the tooth surfaces to prevent tooth decay.

When deeper pockets (6 mm or more) are detected a trial of sub-gingival root brushings has shown to have a very beneficial result within only 14 days.

Periodontal pockets were improved and bacterial counts of periodontal infections also showed improvement.

Mouth flora in alcoholics

This 2016 study from Poland examined the mouth flora of 25 alcoholics. They were compared to the mouth flora of 25 patients from a periodontology clinic.

There were significant differences between the two groups. The alcoholic group had higher bacterial counts of these three strains: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Treponema denticola. There was no difference in bacterial counts between those who drank only little alcohol compared to those who drank lots. The bacterial concentration in the sub-gingival flora was the same. Patients with severe periodontal disease had the same distribution of the three strains of bacteria as chronic alcoholics. However, the concentration of bacteria in alcoholics was much higher. This fact may explain why chronic alcoholics are very sensitive to infections. Alcohol inhibits the immune system, but stimulates the growth of sub-gingival bacteria, which find their way into the system and in serious cases can kill the patient.

Mouth Flora And Your Health

Mouth Flora And Your Health

Conclusion

It is now a well-established fact that mouth bacteria play an important role in our health. Some of the healthy bacteria find their way into the gut providing the foundation of a healthy gut flora. But as described above there are also pathological bacteria that can multiply in our mouth cavity and our gums. This happens particularly in people who do not floss and who develop gingivitis and periodontitis. Tannerella forsythia was associated with esophageal adenocarcinoma. In contrast, the bacterium Porphyromonas gingivalis caused esophageal squamous cell carcinoma. Streptococcus viridans could cause subacute endocarditis, a dangerous infectious disease of the heart valves. Tannerella forsynthesis and Preventella intermedia showed an association with an increased risk for heart attacks.

Bacteria associated with alcoholism

Here are three mouth bacteria associated with alcohol consumption and with chronic periodontitis. They are Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Treponema denticola. Don’t let the strange sounding names of mouth bacteria confuse you. Fact is that these bacteria, when entered into the blood vessels and the rest of the body, will play havoc with your health. Keep brushing your teeth at least twice per day and floss your teeth conscientiously once or twice per day as well. This will improve your mouth flora and your health.

More info: http://www.askdrray.com/flossing-and-brushing-saves-your-heart/

Nov
26
2017

Prevent Cancer, Cut Sugar

If you want to prevent cancer, cut sugar! This is the message of an Oct. 13, 2017 study. The research team had done experiments for 9 years, when they concluded that it was refined sugar that caused spontaneous mutations of RAS proteins. RAS proteins are responsible for cell growth. When a substance like sugar turns them on all the time, they can cause mutations that lead to cancer. In this article research concentrated on yeast cells, and the publication is in Nature Publication. The CNN publication describes this in simpler language. Essentially the research team found that a sugar molecule, fructose-1,6-bisphosphate, was responsible in obese patients and in diabetic patients to mutate a RAS protein, which as a result can turn into an oncogene causing cancer.

Evidence that sugar causes obesity and type 2 diabetes

  1. A September 2017 US study followed 41 children age 9 to 18 with initial fructose consumption of >50 g/d. The treatment of the children consisted of an isocaloric fructose restriction of only 9 days. Following that their liver fat content decreased from 7.2% to 3.8%. In addition intraabdominal fat decreased and new fat production was reduced from 68% to 26%. The authors pointed out that reduction of sugar consumption in obese children was a very effective treatment tool.
  2. This August 2017 study from Helsinki followed 71 obese males for 12 weeks. They consumed 75 grams of added fructose every day in addition to their normal food intake. The liver fat content increased and cardiovascular risk factors worsened as blood tests showed. The investigators concluded that the adverse cardiometabolic effects were a result of the added fructose. They were not secondary to the weight gain (a theory in the past).
  3. This February 2017 study from the US the Taiwanese Healthy Aging Longitudinal Study in Taiwan was also of interest. It consisted of a 5-year long study involving middle-aged and elderly patients with type 2 diabetes. The result was that patients with more physical activity, a better diet and a higher score regarding psychosocial health did much better with respect to managing their diabetes. Maintaining a healthy lifestyle is particularly important for the elderly to prevent diabetes.

Evidence that obese patients and type 2 diabetics get more cancer

  1. In this 2016 study from Poland the effect of diabetes causing various cancers was under investigation. The authors pointed out that worldwide in 2014 there were 387 million cases of type 2 diabetes and it was still rising. When they looked at correlation between various cancers and type 2 diabetes they found that diabetes had the strongest association between pancreatic cancer and liver cancer. But there was also an association between diabetes and breast cancer, bladder cancer and kidney cancer. Head and neck cancers were more frequent among diabetics. Some diabetic medications made cancer frequencies worse, others, like metformin made them better.
  2. In this March 2016 article from the BJC (British Journal of Cancer) cancer frequencies were correlated to patients with obesity and to patients with diabetes. Researchers found that some types of cancer correlated with obesity, whereas others did with diabetes and not with obesity. They found that type 1 diabetes had its own set of cancer risks while type 2 diabetes had a different set of cancers that correlated to the disease

More on cancer risks in diabetics

  1.  A 2015 study from Malaysia with an 11-year follow-up describes that type 2 diabetes had increased in the population which researchers studied. The investigators concentrated on a female population where they found a strong correlation between diabetes and endometrial cancer, ovarian cancer, breast cancer and cervical cancer. In a group of 860 cancer patients they found that 26.5% were diabetics. They were at a much higher risk of getting these cancers.
  2. A 2016 study from the US examined 2,836 veterans who had problems with their esophagus. 1,704 received a diagnosis of esophageal adenocarcinoma, 1,132 of them had gastroesophageal reflux disorder. Among the cancer patients there were 30.8% diabetics. The researchers calculated that for diabetics there was a 2.2-fold higher risk of developing esophageal cancer. The only other risk factor they could identify was nicotine dependence, which showed an association with a 1.7-fold risk of to develop esophageal cancer.

Evidence that sugar causes cancer

As explained earlier research found that fructose-1,6-bisphosphate is responsible in yeast cells to lead to RAS mutations. Human cells have the same metabolism as yeast cells, and they also have RAS protein and fructose-1,6-bisphosphate. Fructose-1,6-bisphosphate is important for cancer development in humans. Yeast cells are diploid cells as are human cells. But yeast cells are not human organisms, so the parallel stops at one point.

  1. A 2014 study from China showed that fructose-bisphosphate aldolase was a marker for lung cancer metastases. This enzyme breaks down fructose-1,6-bisphosphate. Depletion of fructose-bisphosphate aldolase A reduces cell motility of cancer cells and the ability to cause more tumors. In other words, the key for cancer cells to thrive is the presence of fructose-1,6-bisphosphate.
  2. In this 2013 study from Beijing gastric cancer biopsies research examined these samples for fructose-1,6-bisphosphatase, the enzyme that breaks down fructose-1,6-bisphosphate.

The enzyme was under expressed in 86.2% of the gastric cancer biopsies. This meant that glycolysis was stimulated in the cancer cells. An overabundance of fructose-1,6-bisphosphate caused tumor cells to get into an active phase and to metastasize.

Discussion of why sugar causes cancer

I have previously discussed this topic in a blog 3 ½ years ago. At the time a few steps were missing from the knowledge we have today. Nothing has become different regarding the connection of sugar overconsumption and the risk of developing cancer. First of all, we have learnt that fructose overconsumption or sugar overconsumption leads to fructose-1,6-bisphosphate in the blood, which stimulates RAS proteins to mutate and stimulate oncogenes to cause cancer. In addition, people who are overweight, obese or have diabetes have too much insulin production, which can also lead to cancer causation. Finally, obese people have a lot of very active kinins in the blood that can cause cancer as well. In conclusion, what has changed between March 2014 and now is that we have a lot more detail why things happen the way they do. Connections that used to be obscure have now a rational explanation.

The message is that we need to cut out refined sugar from our diet, cut out starchy foods and cut out processed foods. This will improve our metabolism and reduce our risk of getting cancer. We will also lose weight, which I have experienced in 2011 when I lost 50 pounds over 3 months. What did I do? I was just doing what I described to you: cutting out sugar, starchy foods and processed foods.

Prevent Cancer, Cut Sugar

Prevent Cancer, Cut Sugar

Conclusion

Want to reduce your risk for getting cancer drastically? Then cut out sugar and starchy foods along with processed foods (which have too much sugar in it).  Strangely enough it was only now that researchers have found the missing link. The culprit is fructose-1,6-bisphosphate, a metabolic byproduct from sugar consumption. It stimulates a RAS gene, which can mutate, turn into an oncogene and eventually cause cancer. This fact was not known a few years ago. But the knowledge that cancer can occur due to diabetes, obesity and insulin resistance goes back a long time.

We need to learn from science: cut out refined sugar, starchy foods and processed foods. This will change insulin resistance into insulin sensitivity. Fructose-1,6-bisphosphate will not accumulate, but get normally metabolized. This way fructose-1,6-bisphosphate does not pose a problem for RAS proteins. Your insulin level will normalize, the previous kinin overproduction will disappear and your risk for cancer will decrease.

We have allowed the sugar industry to undermine our health for too long. It is time to take back the control over our lives, assess our food habits and make the necessary changes.

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Nov
11
2017

Avoid High Temperature Cooking

In recent years publications have shown that you need to avoid high temperature cooking. This will prevent diseases, and this will also prevent premature aging. Cooking at high temperatures creates carcinogens and advanced glycemic end products (AGE’s). Both substances are harmful to our health. Carcinogens are mutagens that attack the DNA of your cells which increases a risk of developing cancer. AGE’s crosslink proteins like antibodies, hormones, enzymes, collagen, neurotransmitters and hemoglobin. When crosslinking like this has occurred, cells are not functioning optimally.

In the case of diabetes the hemoglobin, which is expressed as percentage of glycated hemoglobin, is rising. This leads to damage of hemoglobin by AGE’s. Above a certain normal value complications of diabetes occur, like blindness or amputations of limbs because of circulatory problems. Diabetics also can get excruciating pains from damage to nerves (neuropathies) and heart attacks. In the last few years it has become evident that the old “normal” glycated hemoglobin values recommended to patients were too high. This was the reason why complications still occurred when the patients’ hemoglobin A1C values were within the normal range.

New hemoglobin A1C ranges

At the 22nd Annual World Congress on Anti-Aging Medicine In Las Vegas (Dec. 10-14, 2014) Dr. Piliszek stated that the normal range for hemoglobin A1C is skewed in the medical literature. It should be: 3.8% to 4.9%. This is very important to know for diabetics and any caregiver who looks after diabetic patients. If you are satisfied with a hemoglobin A1C of 6.0 as still being “normal”, the diabetic patient has the risk of dying prematurely of a heart attack or a stroke. According to the new guidelines even a patient whose hemoglobin A1C is 5.5 has diabetes with the new guidelines and needs to be treated aggressively to prevent complications that occur due to diabetes. Conventional guidelines would have considered this patient to be normal. With these new guidelines there won’t be complications as long as the hemoglobin A1C stays in this range.

In a way diabetes is a special case of AGE’s accumulation leading to glycosylated hemoglobin. The hemoglobin A1C value measurement indicates how advanced the AGE’s accumulation is.

What can we do to lower our exposure to AGE’s?

Here is a list of more than 500 common foods. Keep in mind that less than about 700-kilo units/serving is a low glycation product, 700 to 5000 is a medium glycation product and above 5000 would be a high glycation product.

You can tell by comparing methods of preparing various meats how different the glycation product is. You want to avoid broiling, also you will want to poach eggs at medium heat or panfry foods at low heat to keep the glycation product of our food in the low to medium range.

Is preparing food in a microwave oven safe?

We have been indoctrinated that microwave cooking would be gentle and harmless to the food. Newer research has shown that this is not the case! Microwaves produce heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAHs). This is in addition to advanced glycation end products (AGEs), known as glycotoxins. All of them can damage your cells and can cause cancer. There were many investigations of microwave cooking in Russia and Switzerland that describe the problems.

The result of these studies was that microwaving food produced noxious substances that were carcinogenic, contained free radicals and changed blood composition in the volunteers ingesting microwaved foods. There was a leukocytosis (too many white blood cells); decreased immune cells (lymphocytes) and increased cholesterol levels just from consuming microwaved foods. The researchers concluded that microwaved food contained noxious components to which the body reacted. For years the microwave oven industry and various government agencies in Europe and North America have refuted this kind of information. Nevertheless, many people started to abandon their microwave oven based on this newer research.

Other cooking techniques causing AGE’s

Overcooking foods can also cause massive damage to the genes. Women exposed to AGE’s are at a higher risk of developing breast cancer. Their outlook is much worse than for women without exposure to AGE’s.

High temperature cooking causes inflammation, which in turn stimulates glycation of the body’s proteins. As I mentioned before, broiling, baking, grilling or panfrying at high heat will do exactly that. But broiling, roasting, frying and searing also generate AGE’s. Barbecuing belongs to the high temperature cooking methods as well. Unfortunately many of these methods are common in restaurant cooking. You are much better off to prepare your own meals at home where you have control over how many AGE’s you generate when you prepare your food.

Avoid high temperature cooking with these methods

If you don’t have a slow cooker, now is a good time to get one. The advantage of this method is that you can prepare dinner at breakfast time. If you choose to cook a stew, put your beef or bison in together with onions and vegetables in the morning, and let it cook at low heat. When you come home for dinner in the evening, you can smell when you open the door that dinner is ready. The meat is soft and tasty.

Alternatively, if you prepare meat or poultry, you may want to cook the meat at low heat in the oven until it is through. You can boil eggs or poach them. Cooking salmon or other fish works well with low- heat cooking in the oven. Alternatively steaming produces very good results.

Supplements, if you can’t avoid high temperature cooking

Fortunately for those who depend on restaurant foods, there are supplements that have shown to reduce AGE’s significantly. I am describing them in the following and what studies have shown that they are effective. Also, by reducing sugar and starchy foods, particularly processed foods, you can significantly reduce AGE’s in your diet.

1. Chlorophyllin

Chlorophyllin has been known for many years to be an anti-carcinogenic and antimutagenic. 100 mg taken with the heaviest meal will protect you to a large extent from AGE’s and carcinogens in food that has been cooked too hot.

2. Indole-3-carbinol

Cruciferous vegetables (cabbage, cauliflower and broccoli) contain the substance indole-3-carbinol. In mouse experiments it was suppressing carcinogens by up to 98%. It prevented DNA damage by carcinogens in rats up to 95%.

The dosage for humans is 200 mg twice per day, and it has no side effects.

3. Carnosine

Carnosine consists of two amino acids, L-histidine and beta-alanine. It has anti-AGE’s effects. Because of the carnosine enzyme, which degrades carnosine, it requires a fairly high dose of 500 mg twice per day to get a meaningful blood level.

Diabetics are most in need of protection from AGE’s. Prolonged elevation of blood sugars leads to glycation end products as sugar interacts with protein in the body. Carnosine interferes with this AGE’s formation.

In the past the dosage was too low(only 50 mg per day); newer studies established that for a sustained blood level you need 500 MG twice per day. 

4. Benfotiamine

This is another supplement that is of value in preventing damage from AGE’s.

The interested reader can follow the link and learn more about it.

5. Pyridoxal-5-phosphate

This is a metabolite of vitamin B6. It is also useful to counter AGE’s. Dr. Sahelian is of the opinion that for most patients supplementation with multiple vitamins (which includes vitamin B6) is sufficient to have protection through pyridoxal-5-phosphate as vitamin B6 gets easily metabolized into it.

Avoid High Temperature Cooking

Avoid High Temperature Cooking

Conclusion

Advanced glycemic end products (AGE’s) and mutagens from overheating the food we eat is a significant problem. Conditions like heart attacks, strokes and many cancers can have their root in this. The key is to reduce AGE’s by eating less sugar and starchy foods. A Mediterranean diet is a balanced diet that will help to reduce AGE’s in your diet. Besides that we need to watch that we do not overuse alcohol. It is important that we avoid eating fast foods and restaurant foods. Broiled food, baked items, as well as grilled or pan-fried foods contain AGE’s due to the high heat exposure during . Even microwaving food can produce AGE’s and mutagens in food.

What to do instead

Instead, we need to use a slow cooker, poach eggs at medium heat or panfry food at low heat to keep the glycation products of our food in the low to medium range. Once you see the black char marks on meats or a heavy, dark brown surface, you know, that the exposure to high heat has been too much. Overcooking food presents a problem for your health. If we cannot avoid this exposure, we can resort to several supplements that offer us some relief from AGE’s. It makes sense to use those, if we cannot avoid eating out, and we should take them with the heaviest meal of the day.

Sep
02
2017

Resveratrol Effective In Humans

Resveratrol has been labeled a powerful antioxidant; but is resveratrol effective in humans?

  1. Quack watch says: don’t buy into the hype that resveratrol is effective in humans.
  2. WebMD claims that there would not be enough medical evidence to say that the average person should supplement with resveratrol to receive benefits.

Despite these recommendations the following evidence supports that resveratrol is indeed effective in humans.

Resveratrol effective in humans: high blood pressure patients

A 2017 study of high blood pressure patients examined resveratrol supplementation with two groups, 46 stage 1 hypertension patients and 51 stage 2 hypertension patients. Stage I hypertension had a systolic blood pressure of 140–159 mmHg and a diastolic blood pressure of 90–99 mmHg. Stage 2 hypertension was defined as a systolic blood pressure of 160–179 mmHg and a diastolic blood pressure of 100–109 mmHg. Each subgroup was divided into two groups, one receiving regular antihypertensive medication, and the other group receiving regular antihypertensive medication plus Evelor. Evelor is a micronized formulation of resveratrol. The trial lasted two years. The purpose of the trial was to determine the effect of resveratrol, which was added to the regular antihypertensive medication (or not) to see whether it had blood pressure lowering effects. The interesting result showed that the resveratrol addition was sufficient to bring the blood pressure down to normal levels with only one antihypertensive drug. The control group without resveratrol needed two or three drugs to get the blood pressure under control. In addition, liver function tests showed that resveratrol normalized negative side effects of the antihypertensive drug on the liver. Both liver enzymes, glutamate-pyruvate transaminase (SGPT) and gamma-glutamyl transferase (Gamma-GT) were normal in the group where resveratrol had been added.

Resveratrol effective in humans: diabetes patients

Resveratrol helps diabetes patients. Resveratrol, the bioflavonoid from red  wine is a powerful anti-inflammatory. This antioxidant has several other effects, which make it challenging to measure each effect by itself. This group of investigators managed to simultaneously measure these effects. They found that resveratrol lowered the C-reactive protein by 26% and tumor necrosis factor-alpha by 19.8%. Resveratrol also decreased fasting blood sugar and insulin; in addition it reduced hemoglobin A1C and insulin resistance. The recommended daily dose of resveratrol was 1000 to 5000 mg.

Resveratrol effective in humans: improves bone density

Resveratrol improves bone density in men: 66 middle-aged obese men with an average age of 49.3 years and a mean body mass index of 33.7 were recruited for this randomized, double blind, placebo-controlled trial. The purpose was to study whether there would be changes in bone turnover markers (LDH, an enzyme involved in bone turnover), but also whether bone mineral density (BMD) would increase. Resveratrol was given to a high group (1000 mg per day), a low group (150 mg) and a placebo (fake pills) were given to the third group. The end point was an elevation of the bone alkaline phosphatase (BAP). This was measured in the beginning of the study and at 4, 8 and 16 weeks. The high group of resveratrol had a 16% increase of the BAP throughout the study and a 2.6% in lumbar spine bone density (measured by a trabecular volumetric method). The low resveratrol group showed no bone restoring effect. MJ Ornstrup, MD, the lead investigator said that this was the first time that a clinical team has proven that resveratrol can potentially be used as an anti-osteoporosis drug in humans. She added that resveratrol appears to stimulate bone-forming cells within the body.

Resveratrol effective in humans: anti-aging effects

The Nurses’ Health Study showed that both a Mediterranean diet and resveratrol can elongate telomeres.

The fact that you can have a longer life with a Mediterranean diet is known for some time. But now a study has shown that the reason for a longer life is the fact that telomeres get elongated from the Mediterranean diet. Telomeres are the caps at the end of chromosomes, and they get shorter with each cell division. This is the normal aging process.

The finding of elongated telomeres comes from the ongoing Nurses’ Health Study that started enrolling subjects in 1976. At that time 121 700 nurses from 11states enrolled in the study. In 1980 diet sheets were used to determine who was adhering to a Mediterranean diet. 4676 middle-aged participants were identified to qualify for this study. This diet consists of a combination of vegetables, legumes, fruits, nuts, grains and olive oil. Fish and lean meats were also consumed. The control group followed a regular diet. Between 1989 and 1990 blood tests were obtained to measure telomere length in white blood cells. It is known that smoking, stress and inflammation shortens telomeres. The lead author Marta Crous-Bou stated that overall healthy eating was associated with longer telomeres compared to the control group. But the strongest association was found in women who adhered to the Mediterranean diet when compared to the controls. For the best diet adherence score there was a 4.5 year longer life expectancy due to slowed telomere shortening.

Longer telomeres have been found to be associated with the lowest risk to develop chronic diseases and the highest probability of an increased life span. I have reviewed the importance of lifestyle factors in this blog where I pointed out that Dr. Chang found a whole host of factors that can elongate telomeres by stimulating telomerase. It has been shown in humans that increased physical activity elongated telomeres. So did vitamin C, E and vitamin D3 supplementation, resveratrol, a Mediterranean diet and marine omega-3 fatty acid supplementation. In addition higher fiber intake, bioidentical estrogen and progesterone replacement in aging women and testosterone in aging men, as well as relaxation techniques like yoga and meditation are also elongating telomeres.

Aging is due to shortening of telomeres. Elongation of telomeres by resveratrol leads to prolonged life (or anti-aging).

Resveratrol effective in humans: resveratrol and cancer

As this overview shows, it seems that several mechanisms of action give resveratrol the power to be an anticancer agent. Resveratrol is anti-proliferative and has anti-angiogenesis mechanisms. In addition resveratrol stimulates apoptosis, which is programmed cell death. All these actions together help resveratrol to have anticancer properties. Resveratrol can also be used in combination with other cancer treatments, which improves survival figures. As the link above explains, more cancer clinical trials with a variety of cancers and larger patient numbers are required, but many smaller clinical trials have already been very successful showing efficacy of resveratrol as a chemotherapeutic agent.

In this 2015 publication about malignancies and resveratrol an overview is given about the use of resveratrol and cancer treatment. It summarizes that the development of cancer is a multifactorial process that involves the 3 stages of initiation, promotion and progression. One of the cancer promoting factors is chronic inflammation. Resveratrol has been shown to be anti-inflammatory. At this point it is not clear how the animal experiments will translate into the human situation. More clinical observations are necessary.

Resveratrol effective in humans: cardiovascular disease

Resveratrol has beneficial effects on preventing hardening of the arteries, diabetes, various cancers and inflammatory conditions like Crohn’s disease and arthritis. As this link explains resveratrol also stimulates the antiaging gene SIRT1 by 13-fold. This confirms the anti-aging effect of resveratrol. This 2012 study has also confirmed that resveratrol from red wine is what is responsible for the “French paradox” (longer life expectancy despite high saturated fat intake).

Resveratrol effective in humans: polycystic ovarian syndrome 

Polycystic ovarian syndrome could be significantly healed with resveratrol in a randomized, double blind, placebo-controlled trial. It involved 30 subjects who completed the trial. 1500 mg of resveratrol or placebo were administered daily for 3 months. Serum total testosterone was decreased by 23.1% at the end of 3 months in the experimental group versus the placebo group. There was also a decrease of dehydroepiandrosterone sulfate of 22.2%. Fasting insulin level was reduced by 31.8%. At the same time insulin sensitivity was increased by 66.3%. The authors concluded that resveratrol had significantly reduced ovarian and adrenal gland male hormones (androgens). This may be in part from the drop in insulin levels and the increase of insulin sensitivity.

Resveratrol effective in humans: anti-arteriosclerotic effects in diabetics

A double blind, randomized, placebo-controlled study was done on 50 diabetics. The cardio-ankle vascular index (CAVI) was used to determine arterial stiffness. The purpose of this study was to determine the effect of resveratrol on the stiffness of arteries in a group of diabetics and compare this to a placebo. Diabetics are known to have premature hardening of the arteries (arteriosclerotic changes). After 12 weeks of taking 100 mg of resveratrol per day there was a significant reduction in arterial stiffness in the experimental group, but not in the placebo group. Blood pressure also decreased by 5 mm mercury (systolic) in the experimental group.

Resveratrol effective in humans: ulcerative colitis patients

56 patients with mild to moderate ulcerative colitis received 500 mg of resveratrol or placebo and were observed for 6 weeks. This was a randomized, double blind, placebo-controlled pilot study. Bowel disease questionnaires were used to assess the bowel disease activity before and after the treatment. The resveratrol group decreased the disease activity significantly, but it also increased their quality of life. Blood tests showed that this improvement occurred as a result of reducing oxidative stress by resveratrol.

Resveratrol effective in humans: Alzheimer’s disease prevention

Here is a study where 52 Alzheimer’s patients were divided into two groups; one group was given 200 mg of resveratrol for a number of weeks, the other group placebo pills. There was a significant improvement in memory tests in the resveratrol group and functional MRI scans showed better functional connectivity in the hippocampi of the subjects. It is known that the hippocampus is the seat for short-term memory, which is lost in Alzheimer’s patients.

Resveratrol Effective In Humans

Resveratrol Effective In Humans

Conclusion

Resveratrol has a long history of showing evidence of improving health. It does so by countering oxidation of LDL cholesterol, which lessens hardening of arteries. This prevents heart attacks and strokes. Resveratrol is also a powerful anti-inflammatory, which helps patients with diabetes, with Crohn’s disease and arthritis. There is even a cancer preventing effect of resveratrol because of anti-proliferative and anti-angiogenesis effects as well as stimulating apoptosis. Because of these combined anticancer properties resveratrol is a chemotherapeutic agent that can be combined with conventional anticancer drugs.

There are enough randomized, double blind, placebo-controlled trials in humans to show that resveratrol is effective in preventing and treating several disease conditions. The medical establishment claims that there would not be enough medical evidence to say that the average person should supplement with resveratrol to receive health benefits. After my review outlined above I come to the opposite conclusion. It is quite clear that resveratrol has several important healing properties. It can improve diabetes; prevent hardening of arteries, lower blood pressure, attack osteoporosis and prevent Alzheimer’s disease. I have been taking 500 mg of resveratrol daily for years. It has not harmed me.

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Aug
12
2017

Curcumin And Cancer

Many clinicians give their attention to curcumin and cancer. It may not be used as a primary treatment, but may be added as an adjunct to other cancer treatments. Curcumin is the effective ingredient of the old Indian spice, turmeric. The question is how effective curcumin is against cancer? Is it safe to use? What is the evidence?

Frequency of cancer

According to the American Cancer Society there will be 1,688,780 new cancer cases diagnosed in 2017 and 600,920 cancer deaths will occur in the US.

Causes of cancer

Cancer can be caused in many different ways. Hidden in the many causes may be the possible solution to new cures.

  1. A lack of exercise may contribute to the development of cancer because of a lack of tissue circulation. And exercise will help to support your normal cell metabolism (explained below). Wrong foods may or may not have a contributory role regarding cancer development (a high sugar and starch diet causing insulin response, which changes the metabolism). The Mediterranean diet is an anti-inflammatory diet and has been credited to prevent a lot of cancers.
  2. Cancer can be caused by chemicals, called carcinogens. But it can also be caused by oncoviruses. It can be genetically caused, that’s why it tends to run more often in certain cancer prone families. But Warburg has researched the metabolism of cancer almost 100 years ago, even got the Nobel price for it in 1931 and yet the elusive cancer cure has not materialized yet.
  3. Following Warburg’s research Watson/Crick detected DNA in our cells. Ever since geneticists were fascinated by it. They also found that a cancer suppressive gene, regulated by the p53 gene could develop mutations and then cancer would occur: Tumor Suppressor Genes For decades this was the “in” thing. But in the last 5 to 10 years there is a revitalization of the original Warburg idea that one should concentrate on the metabolic differences between cancer cells and normal cells. This is starting to show some timid results.
  4. Cancer cells are more acidic from lactic acid and burn glucose for energy without requiring oxygen (anaerobic pathway), while normal cells burn glucose in the aerobic pathway in the mitochondria. This difference is important. Cancer cells were found to be more vulnerable to be killed by certain manipulations.
  5. Take cryoablation therapy for prostate cancer. Cryosurgery for prostate cancer. The more vulnerable cancer cells are preferentially killed over the normal cells through a local deep freeze method. Another example is photodynamic therapy for cancer that has been used for lung cancer and esophageal cancer.  This method may be a lot more universally applicable than believed so far. A photosensitized dye is injected and later when normal cells have eliminated the dye, but the defective cancer cells are still containing the dye a laser beam is used to kills the cancer cells preferentially, absorbing the specific laser wavelength that is specific for the dye.
  6. Nobody knows which way cancer research is going. But I think it will be consumer driven: consumers want better cures, and when new methods appear that have better cure rates, these will be pushed forward while less effective methods will become history. I think that Warburg will be revitalized and new therapies will continue to be developed from this as I indicated.

Curcumin and cancer: malignant conversion

There are three development stages for any cancer to develop.

This was originally researched with skin cancer, but also confirmed with cervical cancer. It is called the “malignant conversion” that needs to take place before a normal cell has become a cancer cell. There are three stages.

  • Initiation
  • Promotion
  • Progression

This is important to know in the context of curcumin. Basic research has shown that curcumin interferes with all of these stages of tumor development, both in terms of prevention as well as in terms of being curative. Here is a link that points out the complex multiple steps of cancer growth that curcumin interferes with.

As can be seen from it, curcumin interferes with the initiation of multiple cancers, reduces inflammation, and interferes with angiogenesis and this reduces the amount of metastases that can form. But curcumin further interferes with proliferation of cancer cells, reduces invasion, prevents resistance and improves survival. The underlying molecular and genetic reasons for curcumin’s actions are all contained in that link.

Curcumin and cancer: research in tissue culture and animal experiments

When it comes to cancer research, you usually hear about in vitro culture experiments and animal experiments. This type of research is used to establish that there is an anti-cancer effect, that it is reproducible and non-toxic. The September issue of the 2016 Life Extension Magazine reviewed this in detail. It was entitled “How Curcumin Targets Cancer”.

But as a former clinician I am more interested in seeing cancer patients cured. This has to be verified by clinical trials first. When I looked through PubMed.com for objective evidence of the effects of curcumin in cancer patients, this type of information was more difficult to find. But in the following there are a number of examples that I did find.

Curcumin and cancer: clinical trials

1. Reduction of tumor necrosis factor-alpha

A 2016 meta-analysis of eight randomized studies investigated the effect of curcumin in patients with various inflammatory diseases including cancer. They found that curcumin consistently reduced tumor necrosis factor-alpha. In cancer patients this inflammatory substance is responsible for further cancer growth and developments of metastases.

2. Poor bioavailability of curcumin

A study with increasing amounts of curcumin showed poor absorption of curcumin into the blood. In this study dosages between 500 mg up to 12,000 mg per day of curcumin were given. 500 mg to 8000 mg of curcumin did not result in any positive serum level of curcumin. Only the higher dosages, 10,000 and 12,000 mg of curcumin were associated with positive curcumin levels in the blood serum. In order to have effects of curcumin, higher amounts have to be taken. Higher amounts of curcumin have been tested for toxicity and were found to be safe and were fairly well tolerated.

3. Precancerous colonic polyps reduced in number and size

A smaller study consisted of 5 subjects with familial adenomatous polyposis (FAP). This is an autosomal-dominant disorder where hundreds of colorectal adenomas develop in the lining of the colon. From these colorectal cancer can arise. Five patients received 480 mg of curcumin and 20 mg quercetin orally three times per day. After 6 months the number of polyps and the size had reduced by 60.4%.

4. Premalignant colonic lesions suppressed by curcumin

44 eligible smoker subjects received a baseline colonoscopy where aberrant crypt foci (ACF) were determined. ACI are the very first focal areas in the colon from which colon cancer develops. Smokers are known to have more of these lesions, which was the reason that smoker subjects were used for this trial. The patients received either a supplement of 2000 mg of curcumin or 4000 mg of curcumin for 30 days. These are fairly high doses, but they were used to overcome the poor absorption of curcumin. Colonoscopies were done again after one month of curcumin supplementation. 41 subjects completed the study. In the 4000 mg curcumin group the ACF numbers were reduced significantly by 40% compared to the 2000 mg group, which showed no reduction. The 4000 mg group showed a 5-fold increase of curcumin blood levels compared to baseline. There was no change in blood levels in the 2000 mg group.

5. Reduction of radiation dermatitis with radiation therapy in breast cancer patients

30 breast cancer patients were divided into an experimental group and a placebo group. All of them had a mastectomy first, which was followed by radiation therapy. The experimental group received 6 grams (2 grams three times per day) of curcumin during the time of radiotherapy following mastectomy. The severity of radiation dermatitis following radiotherapy was significantly reduced in the experimental group when compared to the placebo group. Only 28.6% had significant radiation dermatitis in the curcumin group versus 87.5% in the placebo group.

6. Chronic multiple myeloma patients

An Australian study involving chronic multiple myeloma patients found that curcumin at 4 Grams per day and even more so at 8 Grams per day stabilized the disease and improved kidney function.

7. Descriptive studies

Descriptive studies investigating the effect of various doses of curcumin have been done regarding breast cancer,  and advanced pancreatic cancer. But these clinical trials were all rather small.

8. Chemoprevention of cancer

A phase II trial enrolled 21 patients with end-stage pancreatic cancer patients. The only FDA approved treatments for this are gemcitabine and erlotinib, but this would normally only lead to clinical responses in less than10% of patients. In this study the investigators used curcumin to enhance the anti-tumor response of either gemcitabine or erlotinib. The study summary stated: “Oral curcumin is well tolerated and, despite its limited absorption, has biological activity in some patients with pancreatic cancer.” 2 of the 21 patients had stable disease for more than 18 months; one of the 21 patients had a brief tumor regression of 78%, but then relapsed and died.

9. Chemoprevention of cancer

Chemoprevention of cancer is discussed in this publication: There was specific reference made to prevention of prostate cancer and the opinion of the researchers was: “At present, there is no convincing clinical proof or evidence that the cited phytochemicals might be used in an attempt to cure cancer of the prostate.”

Curcumin And Cancer

Curcumin And Cancer

Conclusion

For years there have been reports to indicate that curcumin was a promising natural supplement that can improve cancer survival. There are poorly founded reports of effects of curcumin on colorectal cancer, pancreas cancer, prostate cancer, breast cancer, ovarian cancer and others. But on closer look the hype seems to come mostly from in vitro studies (tissue culture experiments) or from animal studies. Clinicians, however, demand well-constructed randomized clinical trials with clear research objectives before they can accept a new agent like curcumin to be effective. These clinical trials are missing! Instead there are many in-between trials of questionable quality as listed above.

There have been problems of bioavailability due to poor absorption of curcumin. To a certain extent this could be overcome by pushing the dosage to 6000 to 8000 mg per day. But a significant percentage of people (around 30%) suffered from abdominal cramps and nausea and had to discontinue these high doses of curcumin. Newer curcumin compounds have been developed, but at this point it is not known what the bioequivalent dosage is of these newer curcumin agents in comparison to the original curcumin dosages.

It is quite possible that new trials will one day be performed that may bring better news on survival rates of various cancer patients involving curcumin therapy. But in my opinion right now it is not yet prime time for curcumin!

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Jul
01
2017

Advanced Glycation End Products (AGEs)

Advanced glycation end products (AGEs) form when food is cooked at high temperatures. Sugar molecules react with proteins crosslinking them and changing how they function. It prevents proteins from doing their job. Glycation also causes inflammation, which damages mitochondria, the power packages inside cells that provide the body with energy. Overall AGEs lead to premature aging, which comes from the toxic protein reactions. Advanced glycation end products accumulate as glycated proteins in the tissues of the body. This leads to mitochondrial dysfunction.

Effect of advanced glycation end products (AGEs) on the body

The following tissues are frequently affected by the toxic effect of AGEs.

  • The accumulation of AGEs can cause kidney disease and kidney failure (renal failure). In this case the kidneys no longer filter the blood to excrete waste. Hemodialysis may be required.
  • Joint cartilage is damaged by AGEs so it can no longer handle stress and joint stiffness sets in. AGEs are now recognized as a major cause of osteoarthritis.
  • Cross-linked proteins from AGEs can cause Alzheimer’s and Parkinson’s disease. Damaged proteins accumulate in brain cells that disable and kill them eventually.
  • Glycation of LDL particles has been well documented as an important cause of increasing the plaque formation in arteries by LDL. Glycated LDL is much more susceptible to oxidation than regular LDL. Oxidized LDL causes damage to the lining of the arteries and destroys endothelial nitric oxide synthase. This is a critical enzyme, which is involved in maintaining vasodilatation and blood flow. Once LDL has become glycated, it is deformed and LDL receptors can no longer recognize it. This means that glycated LDL continues to circulate in the bloodstream where it contributes to the atherosclerotic process. It forms a plaque which becomes a reason for heart attacks and strokes. Glycation of LDL is particularly common in patients with diabetes.
  • Glycation of the skin sensitizes the skin to UV light damage. It triggers oxidative stress that increases the risk of skin cancer.
  • Glycation damages our eyes. It causes clouding of the lens (cataracts) and it damages the retina. Macular degeneration can ultimately cause blindness.
  • When glycation affects the discs in the spinal cord, this can cause disc protrusions and disc herniations. Often the spinal nerves that are nearby get injured causing limping and leg or arm weakness.

Nutrients to counter AGEs

There are nutrients that can slow down the rate of glycation and as a result will halt the aging process.

Benfotiamine

Benfotiamine is a fat-soluble form of the water-soluble vitamin B1 (thiamine). It has been shown to reverse glycation in cell cultures and in humans.

As a result the damage to the cells that are lining arteries is reduced. Benfotiamine also counters diabetic neuropathy, retinopathy and nephropathy.

Pyridoxal 5’-phosphate

Pyridoxal 5’-phosphate is a metabolite of vitamin B6. It is similar to benfotiamine in that it counters glycation and dissolves deposited AGEs. It is particularly useful to stop fat and protein glycation. In diabetic patients lipid glycation is often a problem as these authors have shown. Pyridoxal 5’-phosphate traps glucose breakdown products before they become part of glycation reactions.

Carnosine

Carnosine is a dipeptide, made up of the amino acids histidine and beta-alanine. It is found in higher concentration in muscle and brain tissue. It scavenges for free radicals and prevents AGE formation. It is preventing both lipid glycation and protein glycation. This publication states that carnosine can play a role in preventing Alzheimer’s disease. As protein crosslinking is prevented with carnosine, tangled protein clumps cannot accumulate and cause Alzheimer’s disease.

Carnosine also reduces blood lipid levels and stabilizes atherosclerotic plaques. This reduces the risk of plaque rupture, which can cause a heart attack or stroke.

Carnosine also has a mitochondria stabilizing function resisting the destructive effects of oxidative stresses.

Luteolin

Luteolin is a bioflavonoid, which can be found in many plants. It has anti-inflammatory effects and works by suppressing the master inflammatory complex, called NF-kB.  NF-kB triggers the production of multiple cytokines and is associated with many cancers, chronic diseases, autoimmune diseases and septic shock. Kotanidou et al. did an experiment where they injected mice with Salmonella enteritis toxin, either with or without luteolin protection. Without luteolin only 4.1% of the mice survived on day 7. With luteolin protection 48% were alive on day 7.

Luteolin has been shown to be effective as an anti-inflammatory in the brain, the blood vessel lining, intestines, skin, lungs, bone and gums.

All these four supplements are available in the health food store. They work together and would be recommendable in diabetic patients where glycation is most prominent. But these supplements are also useful for older people who want to slow down the aging process in general.

Nutrients to slow down mitochondrial aging

Glycation is linked to mitochondrial deterioration and dysfunction. It accelerates aging in every aspect. AGEs (advanced glycation end products) crosslink proteins, lipids, but also damage enzymes and DNA. Mitochondrial energy production is slowed down by glycation. The end result is a lack of energy and slower repair processes, which all depend on mitochondrial energy production. The following supplements have shown some merit in reversing this process.

Pyrroloquinoline quinone (PQQ)

PPQ is a supplement that is known to produce new mitochondria in cells. This helps the energy metabolism of aging cells to recover.

Taurine

Taurine is an amino acid that is found abundantly in heart and skeletal muscles cells, brain cells and cells of the retina. These are areas in the body with high metabolic rates that can burn out mitochondria. Taurine regulates enzymes in mitochondria that harvest energy from food substances. In patients who experience accelerated aging, a lack of taurine can produce an energy crisis. But supplementation with taurine can rescue the cells by reducing oxidative stress and restoring the function of mitochondria in cells that are aging. Brain cells were putting out new shoots, called neurites when taurine was given as a supplement. This helps to improve brain connection, and preserves memory and cognition.

R-lipoic acid

R-lipoic acid helps with mitochondrial function by being involved with extracting energy from foods. When R-lipoic acid is given to aging animals, their metabolic function improves, the mitochondria become healthier and there are less oxidative stress-inducing byproducts. It protects their liver, heart and brain cells from oxidative stress in their mitochondria. It is becoming known as an energy-giving supplement.

Advanced Glycation End Products (AGEs)

Advanced Glycation End Products (AGEs)

Conclusion

Sugar overconsumption and overcooking food can cause advanced glycation end products (AGEs) where lipids and proteins get cross-linked. This leads to premature loss of organ function. The mitochondria are also slowed down. This creates prematurely aging. Fortunately there are a few supplements like benfotiamine, pyridoxal 5’-phosphate, carnosine and luteolin. They protect against glycation. Mitochondria can also be protected by PPQ, taurine and R-lipoic acid. Although we cannot stop the aging process, avoiding sugar and stopping to consume overcooked food, such as barbecued meats and deep fried food is a sensible step in prevention.

With this approach and some supplements a lot can be done to slow down aging.

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Jun
17
2017

Prostate Cancer Treatment Is Often Inadequate

Prostate cancer treatment is often inadequate when you follow the advice of conventional physicians. The gold standard for prostate cancer treatment is considered to be a radical prostatectomy. Below I am explaining that this often leads to recurrences of prostate cancer in the order of 25 to 35% when patients are followed up for 10-years. There is, however, another method of diagnosing and treating prostate cancer, which reduces the recurrence rate to only 6% at 10 years of follow-up. I will first explain the process of the initial assessment of prostate cancer, and then describe different treatment modalities.

Which prostate cancer biopsy method is superior?

  1. The standard biopsy method consists of 6 to 16 random biopsies via the transrectal approach. However, this approach has two downfalls. One is the danger of infection. The rectum is full of E. coli bacteria, which can be spread into the bloodstream. This can cause septicemia in 1 out of 200 biopsies, which is a medical emergency. It is treated with high doses of antibiotics. The second problem with the standard biopsy method is that 25 to 35% of prostate cancers are missed, which may take 10 years to show up as a prostate cancer recurrence. A careful study by the John Hopkins University, Cleveland, OH still showed a 23% recurrence after 10 years. Conventional specialists tend to downplay this long-term risk, but all of the publications that I have reviewed in my book show similar poor long-term results.
  2. The interventional radiologist, Dr. Gary Onik from Ft. Lauderdale, invented the 3-dimensional mapping biopsy. In this case the needles are inserted through a brachytherapy grid over the perineum, the skin between the scrotum and the anus. The area can be thoroughly disinfected, which eliminates the risk of infection as the needles are placed. The patient is under a general anesthetic, and the specialist inserts between 60 and 90 biopsy needles through the perineum into the prostate gland depending on the prostate gland size. This way the entire prostate gland is probed using biopsy needles, and no area of cancer is missed. The procedure is observed through a transrectal ultrasound (TRUS) probe. Each of the biopsies is carefully labeled and kept track of, so the results from the pathologist can be entered on a map, (hence the name mapping biopsy). This is like a geographical image of the areas where prostate cancer was found. It is not a paper map, but a computer generated ultrasound image of the patient’s prostate gland with overlaying histology results. Because of the higher number of biopsy needles used with mapping biopsies the resolution is much better compared to the TRUS guided rectal biopsies. It also tells the treating physician exactly where the cancer is located, if this is going to be treated with ablative cryotherapy. Dr. Onik has published a 10-year follow-up of 70 prostate cancer patients treated in this way. There was a 100% survival of the prostate cancer patients treated with cryotherapy. 94% were completely free from any recurring prostate cancer. 6% had recurrent disease. These kinds of statistics are unheard of with other treatment modalities. The patients’ ages were between 45 and 77 years at the time of surgery.

My own personal experience with prostate cancer

As I have explained in my book entitled “Prostate Cancer Unmasked”, I was diagnosed with prostate cancer in early 2016. Tests were initiated because my blood PSA (prostate specific antigen) test was elevated. I started reviewing the medical literature to see what was the most optimal survival with the least possible side effects. This is how I came across the name of Dr. Gary Onik who has been a pioneer of prostate cancer research for decades. I was impressed by his extremely low prostate cancer relapse data after 10 years of follow-up. I decided to be treated by him in Ft. Lauderdale, FLA. I had the 3-D prostate biopsy involving 96 biopsy needles (due to an enlarged prostate gland, called prostate hypertrophy). One month later I was treated with ablation cryotherapy, which is the equivalent of a lumpectomy for breast cancer in women. Since then (Aug. 17, 2016) my 3 monthly PSA levels have stayed extremely low meaning that there is no recurrence of prostate cancer. I also have tested negative using the Oncoblot test, an extremely sensitive cancer test that had been positive prior to the prostate cancer surgery.

Combination treatment with ablation cryotherapy and IRE surgery

Dr. Onik told me that he wanted to use two procedures simultaneously in my case to treat my lesions optimally. His concern was the neurovascular bundles that cross through the outer aspect of each lobe of the prostate to the penis. The ablation cryotherapy could destroy them, if he came too close to them, which would result in sexual problems. On the other hand he needed to treat the prostate cancer until all of the cancer cells were dead. The surface antigens would still be intact and would stimulate my immune system to destroy any remaining prostate tumor cells. Dr. Onik has done extensive research regarding the immune response in prostate cancer patients and he was working on a publication in end-stage cancer patients.

The other procedure that was patented in the past and was FDA approved 4 years ago was IRE surgery.

IRE surgery

Another technique pioneered by Dr. Onik is the NanoKnife or irreversible electroporation (IRE surgery).

This is another tumor ablation method using high voltage electrical impulses that put nano-sized holes into cancer cells, but not into surrounding healthy tissue.

Dr. Onik has been pioneering this procedure on prostate cancer patients, but he has also shown in liver cancer that these methods can double the survival rates, compared to conventional treatment methods. Cancer cells are killed by this method, and the released surface antigens of cancer cells stimulate the immune system to further the healing. The interesting finding in Dr. Onik’s past research regarding the IRE surgery is that the neurovascular bundle is not damaged by the IRE surgery within the prostate. With the two lesions in my right prostate lobe Dr. Onik wanted to use mainly IRE surgery, because they were in closer proximity to the neurovascular bundle.

Summary regarding mapping biopsy and prostate surgery

There are several points that impressed me with ablation cryotherapy.

  1. It starts with the mapping biopsy, which gives an exact histological picture of any prostate cancer in your prostate. This provides the roadmap for the surgeon to treat any lesions that are found in the biopsy with ablation cryotherapy. While the biopsies are taken there is transrectal ultrasound guidance (TRUS) using a rectal probe. This helps in locating the cancer 3- dimensionally.
  2. Like the mapping biopsy ablation cryotherapy is done under general anesthetic. The same lesions found with the mapping biopsy are treated now with special Argon sounds, and temperature probes measure the temperature to make sure the cancer was frozen long enough to be destroyed. This is repeated one more time to be certain that all cancer cells are killed.
  3. For cancer lesions too close to the neurovascular bundle to be removed with cryotherapy, the surgeon can use the alternative, IRE or also called NanoKnife. It had been researched in dogs and later in humans that it will  eradicate cancer cells, but not normal cells. It also does not attack the neurovascular bundle. Between the two procedures the entire cancer within the prostate can be removed safely.
  4. This means that the side effects are much less than with conventional prostate surgery. The erectile dysfunction is only temporary for 3 to 5 months, but Cialis and/or Viagra can be titrated to achieve normal sex until your own erections come back. There is no effect on the rectum and no sign of bladder leakage. Problems urinating are only temporary in the beginning and can be overcome with self-catheterization or with an indwelling catheter for a period of time. The end result is that the patient is back to normal, and the prostate cancer is removed.
Prostate Cancer Treatment Is Often Inadequate

Prostate Cancer Treatment Is Often Inadequate

Conclusion

When I compared all of the other prostate cancer procedures to ablation cryotherapy, I came to the conclusion that ablation cryotherapy was the best solution for me. It is straightforward, cancer specific and works with the least amount of damage to the normal surrounding tissue. The 10-year survival was 100% with a tumor free rate of 94%. Another advantage of this method is that anytime the PSA would be elevated in the follow-up blood tests, the mapping biopsy could be repeated, and if a recurrent cancer should be found, the ablation cryotherapy can be done again.

Reference: https://www.amazon.com/Prostate-Cancer-Unmasked-Ray-Schilling/dp/1542880661

May
27
2017

What Your Shopping Cart Reveals

What your shopping cart reveals is what I studied on several of our trips to the US. As I am retired, my wife and I travel quite a bit in the US and find it interesting to watch what people place into their shopping carts.

Typical shopping cart I have observed

The typical shopping cart in a US grocery store seems to consist of white bread, pizza, bacon, hamburger meat, potato chips, cookies, cornflakes, grapes, celery, peppers, strawberries and apples. In addition many people buy prepared breaded chicken strips, milk and an assortment of fruit yogurts.

I like to comment on each of these items, what I am thinking and what precautions you need to be aware of.

White bread and pizza

The problem with white bread and pizza is the wheat, which nowadays is Clearfield wheat. A chemical company from Germany was able to chemically modify the genes of wheat in the 1960’s and 1970’s; in addition they used radiation of the seeds. The farmers liked that the new wheat (called Clearfield wheat) grew with stronger roots, shorter final stems and much larger grains so the yield per acre was higher. This type of wheat was patented under the name of Clearfield wheat and sold all around the world. What was not publicized at the time was that the gliadin content increased manifold from the composition of wheat strains used for thousands of years before. Gliadin gets rid of the glue like substance between the gut cells and causes leaky gut syndrome, something that I heard mentioned at many lectures at several of the Anti-Aging conferences of A4M in Las Vegas. This leads to exposure of immune cells to foreign proteins from the gut, which causes the immune system to hyper react with autoimmune antibodies. As a result, many persons react to wheat with indigestion and digestive problems. They may believe that they react to gluten. It is true that Clearfield wheat also has a higher gluten contents. But any tests for celiac disease will come up empty.

We don’t want to eat this as bread, burgers or pizza: but all of them are baked with the wheat that has been chemically force-hybridized into Clearfield wheat.

Bacon and hamburger meat

A prospective study of 72,113 women over 18 years found a definitive relationship between dietary patterns and cancer and heart attacks. A prudent diet with a high intake of vegetables, fruit, legumes, fish, poultry, and whole grains had a very low cancer and heart attack rate. Conversely a Western diet consisting of high intake of red meat, processed meat, refined grains, French fries, and sweets/desserts led to a higher cardiovascular mortality risk of 22% and a higher cancer mortality risk of 16%.

There is another question you should ask: is it grain-beef or is the beef grass-fed?

Meat from grass-fed beef contains 5-times the amount of omega-3 fatty acids compared to corn- or grain-fed beef. Another issue is corn, if that is fed to beef cattle. There is obviously a deliberate marketing drive claiming that corn-fed beef would have a superior taste.

This link shows that the producers only care about their profit and how much of corn-fed beef they can sell. They do not mention that corn is a GMO crop, so this feed is somehow incorporated into the meat. No one has done long-term experiments to ensure that this meat is safe to eat. Moreover, we do know from measurement that corn-fed meat contains much less omega-3 fatty acids and much more omega-6 fatty acids than grass-fed beef. Cows are meant to be grass-feeding animals. If you want to stay healthy, eat grass-fed beef, but do not consume too much or you put yourself at risk for gout from purine metabolites. Corn-fed and grain-fed beef cattle have a lot more infections including liver disease. To control this, the animals are receiving antibiotics. These antibiotics end up in the meat, which can produce superbugs. These superbgs can enter into humans through the food chain.

Bacon is another food that is not only full of saturated fat, but it contains additives, such as sodium nitrite. Give the matter some thought before you put hamburger meat and bacon into your shopping wagon!

What’s wrong about potato chips, cookies, and cornflakes?

1. Potato chips

Potatoes are rich in carbs, but they are empty carbs. Their glycemic index is in the 70 to 80 ranges. I avoid any carbs that exceed 55 (the upper limit of the low-glycemic index). Strangely enough by the time potatoes are processed into potato chips, the glycemic value is only 51, but this is deceiving. The potatoes have been processed in fat and with tons of salt. We now have a product that surely will be bad for your arteries and cause high blood pressure over the long haul. Another important fact is that potatoes belong to the 12 dirty dozens fruit and vegetables that are heavily sprayed with pesticides (see below).

2. Cookies

Cookies are a mix of various ingredients. Here is a recipe for cookies. This is even a better than average quality cookie recipe as they used unsalted butter as a fat source. In many recipes they use margarine, which is an inferior fat. It contains free radicals from the manufacturing process. It is derived from omega-6 fatty acid vegetable oils. But the worst ingredients of cookies are the nutritionally empty white flour and the sugar. Both together are digested, absorbed as sugar into your blood, and a huge insulin response occurs after you have eaten it. Even the cheap chocolate used for the chips is full of unhealthy table sugar causing your pancreas to overproduce insulin.

3. Cornflakes

As mentioned above corn is a GMO crop and we do not know the long-term effects of GMO food on humans. There are more and more reports about gut dysbiosis, leaky gut syndrome and autoimmune diseases as a result of the breakdown of the gut barrier. Pro-GMO advocates deny these possibilities. I play it safe and stick to organic fruit and vegetables. But cornflakes are also high on the glycemic index (between 77 and 93). Usually there is sugar mixed in, and the starchy component consists of empty calories. It is simply not a sensible food choice!

The dirty dozen: grapes, celery, peppers, strawberries and apples

It is known for some time that certain foods are more contaminated with pesticides than others. Some of these fruit and vegetables contain between 13 and 15 different pesticides from spraying, as this link describes. Potatoes are one of the top contaminated crops among the dirty dozen.

Why is it important to know which crop is contaminated with pesticides? Pesticides are immune disruptors. Vegetables that are supposed to be healthy for us contain residues from insecticides and herbicides that have estrogen-like activities called xenoestrogens.They are known to cause breast cancer in women and prostate cancer in men.

Breaded chicken strips, milk and fruit yogurt

1. Chicken strips

Chicken are fed arsenic type antibiotics for faster growth.

The only way how to protect yourself from this contamination is by buying organic chicken, which I have done since 2001. Also, don’t buy breaded “anything” This brings us back to the wheat story mentioned under “White bread and pizza” above.

2. Milk

Milk in the US often contains antibiotics and genetically modified bovine growth hormone (rBGH), which can cause various cancers in humans as this link shows. Recombinant BGH is banned in Europe and in Canada.

3. Yogurt

Most people like fruit yogurt, which is full of sugar and fruit syrup. Plain yogurt, sweetened with a bit of stevia is healthy. But the moment it is adulterated with minimal amounts of fruit, and high amounts of sugar,this “fruit yogurt” leads to weight gain and hardening of arteries. The best yogurt product is organic 1% or 2% plain yogurt. Use fruit of your choice to make a real fruit yoghurt!

What Your Shopping Cart Reveals

What Your Shopping Cart Reveals

Conclusion

Life is all about decisions. I like to make healthy food choices for myself. When I go grocery shopping, I notice that many people do not seem to give much thought to what they are purchasing. They likely also have never read the details about the type of facts I mentioned above. The ingredients that people buy at the grocery store are the ingredients of the Standard American Diet, a sad state of affairs indeed.

The key is to avoid wheat products because Clearfield wheat leads to leaky gut syndrome and autoimmune diseases. Next avoid processed foods and added sugar. What I have not mentioned above is the importance of cutting down on omega-6 fatty acids and to increase omega-3 fatty acids (fish, fish oil supplements). Omega-3 fatty acids are anti-inflammatory. Omega-6 fatty acids stimulate the arachidonic acid pathway leading to hardening of arteries and arthritis. This leads to stents of the coronary arteries and joint replacements of the hips and knees.

Avoid the dirty dozen of crops and buy them organic instead. Avoid milk products in the US; instead buy them organic to avoid exposure to recombinant bovine growth hormone.

It takes a bit of homework and re-education to eat healthy foods. Start reading labels! If a ten year-old cannot read the name of an additive, it should most likely be a signal for you not to buy this product! The more processed food is, the less nourishing it is likely to be. It is not a huge effort to educate yourself about products, but it does take time to steer away from old habits that are not the best for your health. Ultimately your efforts will pay dividends in terms of good health for years to come!