The previous three blogs have dealt with telomeres, stem cells and lifestyle as a theme. In this blog you find summaries from three talks at the 22nd Annual World Congress on Anti-Aging Medicine In Las Vegas (Dec. 10-14, 2014) that dealt with telomere length and how nutrition can positively influence what our genes express, which ultimately determines how long we live. This is at the center of anti-aging medicine and this is why I dealt with it in some detail.
1) Dr. Theodore Piliszek: “Personalized Genetics: Applying Genomics to General Health, Nutrition, and Lifestyle Modification”
The individual’s metabolism is different from one person to the next. As a result of this, one needs to match the diet one recommends for a patient to that person’s genetic make-up.
The Mediterranean diet has 20% protein, 35% fat, 45% carbs; here is the composition of other diets:
Low carb diet: 30% protein, 30% fat, 40% carbs
Low fat diet: 20-25% protein, 20-25% fat, 50-55% carbs
Balanced diet: 20% protein, 25% fat, 55% carbs
Snack only on low caloric foods; otherwise leptins react and make you hungry. A sweet tooth predisposes you to develop diabetes. Lactose intolerance is more common than previously thought. 30% of type II diabetics presently will develop dementia and Alzheimer’s is now often referred to as type III diabetes. With sugar being present in so many processed foods, this figure will likely jump to 60% in the future!
Methylation is very important for your well being. Here is a quick link to explain methylation in simple terms without getting too much into biochemical nomenclature. Having said this, vitamin B2, B6, B12 are needed for this biochemical process, SAMe is also a supplement that supports methylation.
If you do not have a longevity gene, you need to watch that you stick to organic food, stay active, may be add methylated folate and vitamin B12. Each patient should get a supplement list that is customized.
The health practitioner should ask the patient to keep a food diary for 1 week, which gives the doctor the nutritional profile including what the patient consumes in the way of drinks. Check vitamin D3 blood levels! Adequate levels of vitamin D3 are necessary for the musculoskeletal system and the immune system. Endurance training is important up to age 45. Beyond that age emphasis should be on isometric exercises (weight lifting).
Dr. Piliszek stated that the life expectancy in the US is falling behind many other countries. I did a quick Google check regarding life expectancy around the world as follows: US: 78.7 years; Canada: 81.2 years; France: 82.7, Italy: 82.9; Spain: 82.3; Portugal 80.37; Sweden: 81.7; Denmark: 80.05; Norway: 81.45; Germany: 80.89; Poland 76.8; Russia: 70.56. Seeing that the conference took place in the US, there is a lot of room for the US to improve habits with regard to food intake.
Dr. Piliszek stated that the normal range for hemoglobin A1C is skewed in the medical literature and the recommendations are too high; it should be: 3.8 to 4.9 %. This is very important to know for diabetics and any caregiver who looks after diabetes patients, because if you are satisfied with a hemoglobin A1C of 6.0 as still being “normal”, the diabetic patient dies prematurely of a heart attack or a stroke. Contrary to the National Diabetes Information Clearinghouse (NDIC) recommendation it is important to take note: the new normal range for hemoglobin A1C is 3.8 to 4.9%! A patient whose hemoglobin A1C is 5.5 has diabetes and needs to be treated aggressively to prevent complications associated with diabetes.
2) George Rozakis, MD: “Nutrigenomics”
This talk focused on how one could use nutrition to heal when genetic errors are present in the metabolism. This field is called “nutrigenomics”. It deals with using diet modifications and nutrients to change gene expression. Another way to express this is that with proper epigenetic changes by using the right nutrients for a person with an inherited weakness, using the right nutrients for a person with an inherited weakness can extend life. At the same time you need to avoid nutrients that would harm a person with a certain genetic weakness.
We all have inherited some minor or not so minor genetic errors in the genetic code. We are made up of 50 trillion cells with 30,000 genes and 23 pairs of chromosomes, so there are bound to be a few minor genetic code errors that make us more or less susceptible to develop disease, particularly when our telomeres are shortening with age making self-repair of many of our aging cells difficult, if not impossible.
Genes program our cells to run biochemical reactions within the cells. Correct methylation pathways are important for normal cell function. However, if there is a methylation defect, abnormalities set in and homocysteine accumulates.
With various enzyme defects you need to use appropriate supplements to normalize the metabolic defect. Vitamin B2, B6 and B12 supplementation will often stabilize methylation defects and homocysteine levels return to normal. This is important as severe, familial cardiovascular disease can be postponed this way by several years or more.
In a similar vein Dr. Rozakis mentioned that 92% of migraine sufferers have a defective methylation pathway involving histamine overproduction and they can be helped with a histamine-restricted diet.
Autism, ADHD (hyperactivity) and learning disabilities are other diseases where methylation pathway defects are present. Every patient with autism should be checked for methylation pathway defects, and appropriate supplements and diet restrictions can help in normalizing the child’s metabolic defects. DAN physicians (“defeat autism now”) are well versed in this and should be consulted.
S-adenosylmethionine (SAMe) defects are another type of methylation defect, which is important in certain liver, colon and gastric cancers.
Dr. Rozakis went on to say that methylation defects lead to disbalances between T and B cells of the immune system and are important in autoimmune diseases like lupus or rheumatoid arthritis.
Methylation defects can also cause autoimmune thyroiditis and type 1 diabetes. They can also cause cardiac disease by raising homocysteine levels, which causes dysfunction of the lining of arteries and premature heart attacks.
Epigenetic factors through global methylation defects from vitamin B2, B6 and B12 deficiency cause many different cancers. Hypomethylation is the most common DNA defect of cancer cells.
Mental illness is another area where epigenetic factors play an important role. Depression that responds only partially or not at all to SSRI’s (antidepressants) often responds to L-methylfolate, a simple supplement from the health food store as a supplement. Similar epigenetic approaches can be used to treat psychosis, schizophrenia, bipolar disorder and Alzheimer’s disease.
With skin diseases it has come to light that atopic dermatitis, eczema, psoriasis, scleroderma and vitiligo are related to methylation.
When we age, certain hormones are gradually missing, which leads to menopause and andropause. This leads to impaired cell function, elevated cholesterol, arthritis, constipation, depression, low sex drive, elevated blood pressure, insomnia, irritable bowel syndrome and fatigue. Replace the missing hormones with bioidentical ones and symptoms normalize.
3) Dr. Al Sears: “Telo-Nutritioneering: The latest generation of telomere modulators”.
Shortened telomeres are causing cells to behave like old cells. In the lab we can lengthen telomeres. Telomerase activated animals regrew their brains!! In the human situation the goal is to find ways to preserve the length of our telomeres in all our key organs. Alternatively this can also be reached by inhibiting the breakdown of the enzyme telomerase, which will lead to a lengthening of telomeres. In his research Dr. Sears found at least 123 nutrients, vitamins and natural compounds that will elongate telomeres, often by stimulating telomerase.
Testing for critically short telomeres (HT Q-FISH method) is clinically more important than using average telomere length tests. Dr. Sears said when a patient has been shown to have short telomeres and this patient is started on telomerase stimulating supplements, telomere lengthening can be documented within one month of starting the supplementation. Acetyl-L-carnitine and resveratrol are two substances that reliably elongate telomeres.
Vitamin C will significantly delay shortening of telomeres, which translates into delayed aging. In addition vitamin C has recently been shown to stimulate telomerase activity in certain stem cells. There is an herb, called Silymarin extract, which was found to increase telomerase activity threefold. N-acetyl cysteine is a building block for glutathione, a powerful ant-oxidant. In addition it has been shown to turn on the human telomerase gene. Other telomerase stimulators are green tea extract, ginkgo biloba, gamma tocotrienol (one of the components of the vitamin E group), vitamin D3 and folic acid.
Dr. Sears suggested that we should take the following supplements and vitamins for “telo-nutritioneering” (alphabetically arranged) with recommended dosages:
Acetyl L-carnitine: 1,000 mg daily; alpha tocopherol: 400 IU daily; folic acid: 2 mg to 5 mg daily; gamma tocotrienol: 20 mg minimum daily; ginkgo biloba: 40 mg to 80 mg daily (cycle every 4 to 6 weeks); green tea (EGCG): 50 mg daily; L-arginine: 500 mg to 1,000 mg daily; N-acetyl cysteine: 1,800 mg to 2,400 mg daily; resveratrol: 10 mg to 20 mg daily; silymarin: 200mg twice daily; vitamin C: 540 mg minimum daily; and vitamin D3: 2,000 IU daily.
Even if you are only taking 5 or 6 of these twelve telomerase boosters daily, you are doing well, particularly if you are also watching your lifestyle (regular exercise, not smoking, cutting out excessive alcohol intake and avoiding sugar).
This is only the beginning of rethinking epigenetic treatment approaches. For too long organized medicine has used a “cookie-cutter” approach of diagnosing and treating diseases. Now we are realizing that changes in hormones and shortening of telomeres with aging can cause inflammation and premature deaths. The future of medicine, which has already started, uses nutritional changes, vitamins and supplements, bioidentical hormone replacements and exercise to stabilize cell metabolism and postpone age-related diseases.