Apr
11
2020

Our Immune System Needs Vitamin D3

When we age, our resistance to infections weakens, but this may be because our immune system needs more vitamin D3. I have reviewed the super powers of vitamin D3 before in 2014. In the past it was thought that the human body would need only 400 IU of vitamin D3 every day to cure rickets. And this was the daily recommendation for vitamin D3 for several decades. Gradually it became known that for cancer prevention, infection prevention, cardiovascular illness prevention and for diabetes prevention much higher doses of vitamin D3 were needed. As this link points out, almost 50% of the world population is deficient in vitamin D. This is due to a lack of exposure to sunlight and due to inadequate supplementation with vitamin D3.

25-hydroxy vitamin D level

For several years now the 25-hydroxy vitamin D level in serum is accepted as the best tool to assess the vitamin D status of a person.  In the following you find data from this link.

Various 25-hydroxy vitamin D levels

Vitamin D deficiency (leading to rickets in infants or osteomalacia in adults): less than 12 ng/mL (less than 30 nmol/L)

 Inadequate vitamin D levels in healthy individuals (inadequate for bone or general health): 12 ng/mL to less than 20 ng/mL (30 to less than 50 nmol/L)

 Considered adequate for bone and overall health: 20 or more ng/mL (50 or more nmol/L)

 “Emerging evidence links potential adverse effects to such high levels”: >50 ng/mL(particularly >60 ng/mL); or >125 (particularly >150 nmol/L)

Vitamin D requirement in diseases other than rickets

We see from this that in terms of rickets there is a clear dose-response curve, where low vitamin D serum levels give a child rickets and higher levels prevent rickets. This is historically how vitamin D was detected as a vitamin. In the meantime, researchers have found vitamin receptors on many cells, so that endocrinologists consider vitamin D3 a hormone and signalling molecule.

The above link said that a vitamin D level of 20 to 50 ng/mL is normal. This link says that 20 and 40 ng/mL would be normal. But it adds that others recommend a level between 30 and 50 ng/mL.

Mortality of ICU patients is higher when vitamin D is low

A study from 2015 examined the mortality of 135 ICU patients. The researchers correlated Vitamin D blood levels with mortality rates of the patients. When vitamin D levels were below 12 ng/mL, there was a mortality rate of 32.2%. Patients with higher levels of vitamin D had a mortality rate of 13.2%. The authors concluded that low vitamin D blood levels were an independent risk factor for mortality. Patients less than 12 ng/ml had a 2.4-fold higher risk of dying than patients with normal vitamin D levels.

Stroke patients with low vitamin D worse off

Studies have shown that patients with the lowest level of vitamin D have the poorest functional outcomes following a stroke. When the vitamin D level was below 30 ng/mL the area of dead brain tissue was about two times larger than in those who had adequate vitamin D levels. Moreover, for every 10 ng/mL decrease in vitamin D levels the odds of a healthy recovery 3 months after the stroke fell by about half. This was independent of age and the initial stroke severity.

Seasonal vitamin D3 deficiency from January through April contributes to influenza

In a publication of 2006 Dr. John Cannell and co-workers have reviewed why influenza has seasonal outbreaks. They found that the innate immune system was very dependent on vitamin D3. Those who did not get enough sunlight in the northern hemisphere during January, February, March and April have an average 25-hydroxy vitamin D level of only 15 to 17 ng/mL. In contrast, from July to September the same volunteers had vitamin D levels of 24 to 29 ng/mL. The authors stressed that this was the reason why in the late winter/early spring flu seasons come and go every year while in summer they disappear.

Vitamin D requirements for immune system is 2000 IU or more per day

Vitamin D is essential for the functioning of the innate and adaptive immune system. They also had a reason why children are not as affected by influenza viruses as adults are: “The innate immunity of the aged declined over the last 20 years due to medical and governmental warnings to avoid the sun. While the young usually ignore such advice, the elderly often follow it”. Had the older patients taken higher doses of vitamin D3 every day their immunity would have been as strong as the children’s immunity. The publication cites another publication that found that 2000 IU per day or more will strengthen the immune system. Note that this is a higher dose than for rickets that responds to only 400 IU of vitamin D3.

Patients with many diseases lack vitamin D, but improve with vitamin D3

Many diseases showed an association with an underlying lack of vitamin D. When doctors examine patients’ blood who have arthritis, cardiovascular disease, breast cancer, diabetes, osteoporosis, influenza and others, their 25-hydroxy vitamin D level is usually below 15 ng/mL. This means that these patients have a very weak immune system. Vitamin D3 can restore their immune system and also restore more than 100 polypeptides that contribute to the healing process.

Here is evidence from US researchers that states that higher doses of vitamin D3 will mitigate the course of influenza and of Covid-19 coronavirus. The researchers outlined vitamin D has 3 effects:

  1. Maintaining tight epithelial junctions making it more difficult for the Covid-19 coronavirus to penetrate.
  2. “Killing enveloped viruses through induction of cathelicidin and defensins.” These powerful antiviral polypeptides can kill viruses that have invaded the blood stream within 1 to 2 days.
  3. “…And reducing production of proinflammatory cytokines by the innate immune system, thereby reducing the risk of a cytokine storm leading to pneumonia.” It is people who get the viral pneumonia that are at a high risk of being killed. By bringing the blood level up to the higher range of normal, between 50 and 80 ng/mL, patients that have encountered Covid-19 coronavirus are more likely to survive.

Higher doses of vitamin D3 for various diseases

Dr. Norman Shealy has summarized here what Dr. Joe Prendergast, an endocrinologist and diabetologist did for various patients. This link also contains many references regarding the use of high doses of vitamin D3.

During 30 years of clinical practice Dr. Prendergast treated some conditions where the vitamin D level was extremely low and where patients had a profound weakness of the immune system.

He treated these patients with 50,000 IU of vitamin D3 daily for various times. The diseases that responded to vitamin D3 therapy follow.

Conditions responding to vitamin D3 therapy

  • Reversal of advanced coronary disease
  • Reversal of advanced lung disease, avoiding a lung transplant!
  • Cure of multiple sclerosis
  • Cure of amyotrophic lateral sclerosis
  • Regression of rheumatoid arthritis
  • Improvement in allergies
  • Control of many cancers including prostate, breast, colon, brain tumors, leukemia, myeloma, etc.
  • Reversal of osteoporosis
  • Prevention of influenza
  • Cure of depression and many other mental disorders
  • Hashimoto’s hyperthyroidism

No toxicity with higher doses of vitamin D3

LinkedIn summarizes Dr. Prendergast’s career as follows:

“J. Joseph Prendergast has been a practicing physician for over 30 years. He is Board Certified in Internal Medicine as well as Endocrinology and Metabolism. A graduate of Wayne State University in Detroit, Michigan he completed a fellowship in Endocrinology and Metabolism at Henry Ford Hospital Detroit, MI and his residency at the University of California, San Francisco. Dr. Prendergast has published over 40 medical articles in well-known publications such as the Journal of the American Medical Association, The New England Journal of Medicine and Diabetes Care.”

Do not take calcium supplements when on higher doses of vitamin D3

Dr. Prendergast had no complications in patients with these high doses of vitamin D3, but he stressed that the patient is instructed not to take calcium supplements to prevent high calcium levels. He checks vitamin D blood levels and aims at levels of 80 to 150 ng/mL.

The dosage suggested on this audiotape is 50,000 IU per day for one week, then a maintenance dose of 50,000 IU once per week (=7143 IU per day). But it is also important to change your nutrition to a well-balanced diet. He stated that there is no toxicity with this treatment schedule as long as you do not take additional calcium supplements. On the other hand, dairy products are OK to take.

Our Immune System Needs Vitamin D3

Our Immune System Needs Vitamin D3

Conclusion

Many patients with diseases like osteoporosis, high blood pressure, cardiovascular disease, influenza, multiple sclerosis, allergies and other disease listed above have very low vitamin D blood levels. Vitamin D is necessary to produce more than 100 polypeptides. The body requires these for normal cell function. Rickets was first cured by supplements of only 400 IU of vitamin D3 per day. In the meantime, it is recognized that a vitamin D level of less than 15 ng/mL constitutes a vitamin D deficiency. To cure other diseases requires much higher vitamin D levels in the blood, in the order of 50 to 80 ng/mL.

Dr. Prendergast uses higher vitamin D levels with better results

Dr. Prendergast states that patients with pre-existing diseases have to take much higher levels of vitamin D3. This rebalances their metabolism and cell function. In time this will gradually cure their disease. He suggests 50,000 IU of vitamin D3 daily for 7 days. This is then followed by 50,000 IU per week (7143 IU per day) for maintenance. He said that this will lead to a vitamin D level of between 80 and 150 ng/mL. In 30 years of practice he has not seen a single case of vitamin D3 toxicity, provided the patient refrains from taking calcium supplements. This is the exact opposite of what the Mayo Clinic or Harvard University websites say. It also shows that there are always some pioneering forces in the generally ultra-conservative medical society.

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About Ray Schilling

Dr. Ray Schilling born in Tübingen, Germany and Graduated from Eberhard-Karls-University Medical School, Tuebingen in 1971. Once Post-doctoral cancer research position holder at the Ontario Cancer Institute in Toronto, is now a member of the American Academy of Anti-Aging Medicine (A4M).

Comments

  1. Is there any evidence of increased risk of developing kidney stones when taking vitamin D3 supplements?

    • Here is a recent study that followed postmenopausal women with vitamin D3 and calcium supplementation: https://www.medicalnewstoday.com/articles/247284#1. In one year there was not a single case of kidney stones, although there were times when the blood calcium and the urine calcium were high. This means that the body regulates calcium levels to stay the same. If you take vitamin D3 supplements, it is best not to take extra calcium supplements. The calcium in dairy products is high enough to treat osteoporosis.The endocrinologist, Dr. Prendergast has stated this for over 20 years. But anybody who takes vitamin D3 supplementation should also take 200 micrograms of vitamin K2 daily as together with vitamin D it will remove calcium from the arteries and deposit the calcium into the bones where calcium should be. This is important both for women and males. Your blood vitamin D level should not exceed 50-80 ng/ml, which is the high normal range.

    • Here is another study that showed that in the range of 20 ng/mL to 100 ng/mL there is no danger of kidney stone formation: https://health.ucsd.edu/news/releases/Pages/2013-10-17-vitamin-d-and-kidney-stones.aspx There were older studies decades ago that had confounding problems, but websites like the Mayo Clinic and other “official” sites steadfastly base their judgement on these older, false studies.

  2. Hello, I just wanted to add my 2 cents on this article. I moved to my current city a couple of years ago and my new Dr. noticed that I was very low in Vitamin D. She put me on Vitamin D3 5000 I.U. supplementation daily, she said that I was to take that for the rest of my life. I have low bone density.

    I just want to say that I have a certain virus that comes under stress such as overeating on sugar, not getting adequate sleep, etc. I have not have this virus since starting the Vitamin D3 5000 I.U.

    I see many people questioning why some people get no symptoms of coronavirus and become carriers and why some people get very sick and eventually die from the coronavirus.

    I have been doing some research and find that Vitamin D seems to strengthen your immune system. Vitamin D also makes it difficult for the coronavirus to attach to your cells Having enough Vitamin D in your system, and not be deficient, seems to be the answer.

    So far, I have not been sick or had any symptoms of coronavirus. If I happen to exhibit symptoms of coronavirus, I will be taking a protocol – the Vitamin D hammer and also adding extra Vitamin C. It would be a good test to see if the Vitamin D hammer along with extra Vitamin C is the solution.