• What lowers LDL cholesterol?

    What lowers LDL cholesterol?

    Many times we hear terms like LDL and HDL cholesterol , but what lowers LDL cholesterol? We have to go back to a time when the ongoing Framingham Heart Study wanted to find out what caused a heart attack or a stroke. In the 1960’s scientists found out that cigarette smoking increased heart attack risk and also blood … [Read More...]

  • Sex Stimulates Your Brain

    Sex Stimulates Your Brain

    Sex usually causes positive feelings, but how is it that sex stimulates your brain? Recently this publication reviewed exactly what is going on. The reason both sexes seem to seek out sex is the fact that it is sex that stimulates the brain a certain way, which is pleasing to both partners. Due to the stimulation … [Read More...]

  • The Benefits Of Drinking Green Tea

    The Benefits Of Drinking Green Tea

    Chances are you heard about the benefits of drinking green tea to reduce heart disease. But the polyphenols of green tea also prevent cancer, depression and cognitive decline. Green tea lowers cardiovascular mortality A study in the Chianti region of Tuscany, Italy consisted of 807 men and women aged 65 years and … [Read More...]

  • Animal Protein Is Bad And Nut Protein Good For You

    Animal Protein Is Bad And Nut Protein Good For You

    Recently a study from California and France showed that animal protein is bad and nut protein good for you. This review goes back to  this original study from April 2, 2018.  Other studies have shown that there is a higher mortality with a meat-based diet. How the study was done Researchers followed 81,337 men and … [Read More...]

  • 3 Cups Of Coffee Stop Clogged Arteries

    3 Cups Of Coffee Stop Clogged Arteries

    There is a new coffee study that says 3 cups of coffee stop clogged arteries. The study appeared in the Journal of the American Heart Association on March 24, 2018. It was part of the cross sectional Brazilian Longitudinal Study of Adult Health. This study took place from August 2008 to December 2010. It followed … [Read More...]

  • Where Does Fat Go With Weight loss?

    Where Does Fat Go With Weight loss?

    People often wonder where does fat go with weight loss? This question recently came up in a CNN conversation.  The answer was originally researched by Dr. Ruben Meerman and Professor Andrew Brown. Dr. Meerman is an assistant scientist at the University of New South Wales and author of "Big Fat Myths: When You … [Read More...]

    Mar
    10
    2018

    Dementia From Excessive Alcohol Abuse

    A new study from France documented dementia from excessive alcohol abuse. One million patients who needed admission to hospitals in France for early dementia took part in that study. This was based on this publication. Dementia is a clinical syndrome, where the cognitive ability deteriorates progressively.

    The study from France regarding dementia from excessive alcohol abuse

    According to the French National Hospital Discharge database it was especially relevant that alcohol use disorders were present in 16.5% of the men and 4% of the women with dementia. Those who did not have the diagnosis of dementia had only half the amount of alcohol abuse disorders in both sexes.

    There are other diseases that can lead to dementia like Parkinson’s disease and Huntington’s disease. These cases were not part of this study.

    The association with alcohol abuse was particularly evident in early dementia cases at an age below 65.

    Furthermore, alcoholics also have a shorter life expectancy.

    Several mechanisms responsible for dementia development

    Alcohol can cause dementia in several ways.

    • First of all, alcohol and the metabolic by-product acetaldehyde have toxic effects on the brain. They cause long-term toxic effects and functional brain damage is the result.
    • Furthermore, heavy alcohol abuse leads to liver damage with resulting changes in metabolism. Ammonia production from the cirrhotic liver causes brain damage in a condition called hepatic encephalopathy.
    • In addition, heavy drinking is a strong vascular risk factor. This leads to diabetes, high blood pressure, heart attacks and strokes.
    • Often it is the population group that is uneducated, people who smoke and people with depression who suffer from the effects of alcohol abuse.
    • Finally, heavy drinking is more frequent in men than in women. In men the dementia risk was 4.7-fold, in women 4.3-fold.
    • Obesity, smoking and high blood pressure are also risk factors for dementia. If these cases were not part of the study, heavy alcohol abuse caused an increase in dementia in both sexes by a factor of 3-fold.

    Possible biases of the study

    Dr. Kostas Lyketsos, a neuropsychiatry professor and director of the John Hopkins Memory and Alzheimer’s Treatment Center did not take part in the study and its investigation. A non- biased observer, Dr. Kostas Lyketsos stated that there is a problem with precision of the data the larger the study population is. In this case there were more than 1 million participants, so a number of biases can influence the outcome of the study. For instance, one problem is that these patients with mild cognitive impairment were inpatients in a hospital. Normally such patients would not be in a hospital. Another fact was that none of the participants had received questionnaires of the amount of alcoholic drinks they consumed, and as a result it is difficult to knows exactly how high the amount of alcohol was that caused the damage to the brain.

    Country bias

    The large sample size was from only one country, France. This means that we do not know whether there would be ethnic differences between countries. Nevertheless the findings of this study are important. In a 2014 review by the WHO the average person in France consumed 12.2 liters of pure alcohol per year. In contrast the average person in the US consumed only 9.2 liters of pure alcohol in this year. Apart from these concerns it is important to realize that alcohol has toxic effects on the brain. This can also result in dementia.

    Other studies regarding alcohol abuse and dementia

    The media has praised alcohol for preventing heart attacks. On the other hand, there are other articles in which we hear about alcoholic hepatitis and liver cirrhosis, both of which can be killer diseases. To get some clarification, let us examine the various facts.

    Dr. Finnel mentioned that 7.9% of all emergency room visits in the US are due conditions which have an association to alcohol(Ref.1). When the causes of deaths  that are a consequence to alcohol are listed, they are: cancer of the mouth and pharynx, alcohol abuse disorders, coronary heart disease causing heart attacks, cirrhosis of the liver, traffic accidents, poisonings, falls and intentional injuries. You don’t get that from the news. Instead you read about the one glass of red wine per day that is good for women and up to two glasses of red wine that is good for men to prevent heart attacks and strokes.

    Bioflavonoids

    It is the bioflavonoids and among those in particular resveratrol, that are the active ingredient responsible for heart health.

    Resveratrol is a powerful antioxidant that protects against ischemia-reperfusion injuries.  It is responsible for the cardio protective properties of red wine known as the “French paradox” (Ref.2). According to this reference resveratrol contributes to at least 3 processes that stabilize the metabolism.

    Toxicity of alcohol

    According to the WHO 5.9% of all deaths worldwide is a consequence of alcohol overconsumption.  In 2012 the WHO recorded that 7.6% of deaths in males, but only 4% of female deaths were due to alcohol. Toxicity comes from the breakdown product acetaldehyde, which all cells can convert from alcohol. Liver cells are especially able to do that. According to Ref. 3 alcohol diffuses easily through all of the cell membranes and reaches every organ in the body. The toxicity of acetaldehyde is shutting down the mitochondria, which affects the energy metabolism and causes cell death. The immune system reacts with inflammation, when it attempts to repair the damage.

    So, what are the major damages which alcohol can cause? First there is fat accumulation (steatosis), next chronic inflammation followed by necrosis (dying of cells) and finally fibrosis. An example of fibrosis is liver cirrhosis, where non-functioning connective tissue replaces liver cells.

    Different tissue sensitivity to alcohol

    Certain tissues are more susceptible to alcohol toxicity than others. As the concentration of alcohol is highest in tissues that are in direct contact with alcoholic drinks, cancers related to alcohol consumption develop in the oral cavity, pharynx, larynx, esophagus, and in the colon and rectum. The pancreas is particularly vulnerable to inflammation and fibrotic changes with degeneration into cancer of the pancreas. The heart tissue and the arteries are very sensitive to alcohol.  Hypertension, heart attacks, stroke, cardiomyopathy and myocarditis as well as irregular heart beats (arrhythmias) can develop. The brain is very sensitive to toxic effects of alcohol as well. This causes major depression, personality changes with violent behavior, car accidents and injuries.

    Other toxic effects of alcohol on organs

    Kidney disease (alcoholic nephropathy) is another illness due to too much alcohol. Five percent  of breast cancers in northern Europe and North America are a direct consequence to the toxic effects of alcohol (Ref.3). Finally, the liver being so active in detoxifying alcohol, will be not functioning and finally develops liver cirrhosis, as described before. This accounts for a lot of premature deaths at a relatively young age (typically in the mid to late 50’s).

    Ref. 3 goes on to say that literature exists which claims that 1 to 2 drinks per day would be useful for prevention of heart disease. But the observation of the authors is that people will not discipline themselves to stick to these limits and very quickly enter into the zone of alcohol toxicity. The authors further noted that with regard to causing any kind of cancer there is no safe lower limit; the risk is directly proportional to the amount of alcohol consumed and the risk starts right above the zero point.

    The pathologist has the last word

    When I studied medicine at the University of Tübingen, Germany I attended lectures in the pathology department where Professor A. Bohle, M.D. demonstrated pathology findings of deceased patients. Dr. Bohle had a special interest in Mallory bodies. These are alcohol inclusion cysts within liver cells that can be stained with a bright red dye.

    Histological documentation of toxic effects in livers of corpses

    I will never forget when Prof. Bohle pointed out that the livers of this most diverse population, whose bodies we had the privilege as medical students to study, had a rate of 25% positive Mallory bodies. He wanted to impress on us as medical students to watch out for the alcoholics that are usually missed in general practice. Obviously 25% of the pathology population was affected by the consumption of alcohol. It was Prof. Bohle’s hope that we could perhaps interfere on the primary care level before things went out of control. Many of these corpses were the sad results of traffic accidents that could have been prevented. (In 2018 things have changed: seat belts and alcohol limits are standard, in 1968 in Germany they were not).

    Alcohol as an aging substance

    Consistent use of alcohol on a regular basis will slow down cell metabolism and hormone production significantly. The major effect of alcohol leads to poisoning of the mitochondria in multiple organs, which translates into faster aging and a shortened life expectancy. This in turn results in a change of appearance. An older person who has abused alcohol for a number of years may look 5 to 10 years older than their chronological age.

    50% of people above the age of 65 drink daily (Ref.4). Some more statistics: alcohol abuse in elderly men is 4-times higher than in elderly women. 5% to 10% of all dementia cases are related to alcohol abuse. About 15% of older adults are experiencing health risks from abusing alcohol. And about 90% of older adults are using medications. Close to 100% of medications can adversely interact with alcohol (Ref.4).

    Social pressure

    These are the scientific facts, and then there is social pressure, when you are invited to a party.

    When you are young and believe that you are invincible, do you care what the science says? You want to have a “good time” and not worry about consequences. The data about long-term exposure and a slowly increasing cancer risk is there. The wine industry will remind you that 1 drink for women and two drinks for men will protect you from heart attacks. They will withhold the cancer information from you, as they don’t really want to hear about that (yes, it’s bad for their business!).

    Resisting social pressure and doing what is good for you

    Can you have a good time at a party without drinking alcohol? Yes, you can. You can talk and you can listen; you are probably more with it than those who had too much to drink. I like mineral water and hold on to a glass of that.

    I explained in a blog before how I was convinced by three speakers at an A4M conference to join those who abstain from alcohol.

    Socializing without alcohol is doable. You may at times miss it, but you can warm up even to a crowd that had a few drinks too much. It is about choice: we can choose what we want out of life.

     

    Dementia From Excessive Alcohol Abuse

    Dementia From Excessive Alcohol Abuse

    Conclusion

    Alcohol is a cell and nerve poison. The medical need for “one glass of wine for women and two glasses of wine for men to prevent heart attacks and strokes” has been vastly exaggerated. Fact is that resveratrol and other antioxidants like vitamin C and vitamin E can also prevent cardiovascular disease. They are alcohol-free! The risk of dementia development as a long-term result of alcohol exposure is something that is only now getting attention by the medical profession. We live longer these days, and this makes alcohol exposure over the decades a real threat to our mental wellbeing. Consumption of alcohol needs to be re-evaluated by every one of us. What risks are we willing to take? Is the stress-relieving effect of alcohol worth the risk of losing our mind to Alzheimer’s disease? If we care about our future the answer should be clear!

    References

    Ref. 1: John T. Finnell: “: Alcohol-Related Disease“ Rosen’s Emergency Medicine, Chapter 185, 2378-2394. Saunders 2014.

    Ref. 2: “Hurst’s The Heart”, 13th edition, The McGraw-Hill Companies, Inc., 2011. Chapter 54. Coronary Blood Flow and Myocardial Ischemia.

    Ref. 3: Ivan Rusyn and Ramon Bataller: “Alcohol and toxicity”, 2013-08-01Z, Volume 59, Issue 2, Pages 387-388; copyright 2013 European Association for the Study of the Liver.

    Ref. 4: Tom J. Wachtel and Marsha D. Fretwell: Practical Guide to the Care of the Geriatric Patient, Third Edition, Copyright 2007 by Mosby.

    Mar
    03
    2018

    Foods That Can Protect You From Cancer

    There are foods that can protect you from cancer. Generally speaking you want to remove cancer-producing substances from your diet. But diet is only part of your lifestyle that can contribute to cancer. I will list some of the more important dietary factors below and briefly also touch on important other factors.

    Avoid burning your meat 

    When you use the BBQ, avoid burning your meat. As a matter of fact it is a lot better to use a slow cooker at low heat, and cook the meat for a longer time. In this way you won’t create carcinogens, which are cancer-producing chemicals. Healthy Grilling Tips to Minimize Carcinogens in Your Food. This is particularly important for the red meats (like beef, lamb, bison or pork).

    Sugar can cause cancer

    You never thought that sugar and an overabundance of starchy foods can cause cancer, but they do. 5 Reasons Cancer and Sugar are Best Friends.  What is the reason for this? The answer is found in the metabolism of cancer cells. Cancer cells use 10- to 12-times more sugar for their metabolism than normal cells.  Over-consuming sugar is the worst thing a cancer patient can do. Replace sugar by stevia, which is a harmless sweetener. It does not lead to an insulin reaction. You need to avoid all other sugar substitutes as there are other health problems associated with them.

    Avoid macaroni and cheese because of phthalates

    Avoid macaroni and cheese: Phthalates are found in almost every sample of cheese powder used to manufacture macaroni and cheese. Phthalates can cause infertility and breast cancer. Toxic effects of the easily avoidable phthalates and parabens.

    High fat diet

    A high fat diet increases the risk for breast cancer: High-Fat Diet Increases Breast Cancer Risk, Study Finds. Limit your fat intake to about 10% of saturated fat. That is the recommendation of the FDA: New FDA Food Guidelines – Medical Articles by Dr. Ray. Increase your consumption of fish and seafood. Only one proviso: predator fish like shark, marlin, tilefish, swordfish and grouper are high in mercury. But wild salmon, sardines and oysters are low in mercury; so are shrimp and squid. Before You Buy Fish, Check This Mercury Level List.

    Take high dose vitamin D3 supplements

    In order to avoid cancer, take high dose vitamin D3 supplements to avoid cancer. Vitamin D3 in cancer prevention and therapy: the nutritional issue. Strong statistics exist showing that vitamin D3 is a powerful tool to lower your risk of developing cancer. Your family doctor should take a blood test called 25-hydroxy vitamin D level to monitor that you absorb enough vitamin D3. Some people absorb vitamin D3 slowly and fast absorbers absorb it more rapidly.  The only way how to find out how well your gut is absorbing vitamin D3, is by doing this blood test. It is now generally accepted that a good range of the 25-hydroxy vitamin D level is between 50 and 80 ng/ml.

    Also curcumin 500 mg per day is good for cancer prevention. Turmeric | Cancer in general | Cancer Research UK.

    Take enough fiber

    Make sure you take enough fiber, which does not only reduce colorectal cancer, but also many other cancers. Foods for Cancer Prevention. North Americans are not consuming enough fiber. Vitamin D3 in cancer prevention and therapy: the nutritional issue.

    Avoid processed meat

    The World Health Organization has determined that processed meat is causing a lot of cancer. They labeled processed meat as a probable carcinogen. Processed meat causes colorectal cancer, pancreatic cancer and prostate cancer.

    Moderate amounts of fruit and vegetables

    Eat moderate amounts of fruit and vegetables. The claim in the past that fruit and vegetables would protect you from cancer is not as solid as it was thought of in the past. Newer research has shown that a basic intake of fruit and vegetables is needed for essential nutrients, but consuming more than that will NOT protect you from cancer. Fruit and vegetables and cancer risk. This is a case where eating more vegetables or fruit beyond a certain point will not do harm, but it will not protect you further from cancer.

    Drink green tea or black tea

    Drink green tea or black tea, sweetened with stevia for cancer prevention: Winter Beverages for Cancer Prevention. Green tea contains polyphenols and antioxidants. One of the antioxidants is called catechin, which prevents cell damage. The antioxidants help to prevent breast cancer, colorectal cancer and prostate cancer. In addition tea is heart healthy.

    Avoid alcohol consumption 

    Avoid alcohol consumption as much as possible to prevent cancer: Drinking Alcohol Really Does Raise Your Cancer Risk, Doctors Warn. We were indoctrinated by cardiologists that one glass of wine per day for women and two glasses of wine per day for men would be a prevention against heart attacks. But these relatively small amounts of alcohol do have an effect on causing cancer.  This British study showed that small amounts of alcohol indeed are cardioprotective. In contrast, these amounts and higher alcohol amounts can also cause cancer of the pharynx, larynx (voice box), esophagus, liver, breast, colon and pancreas.

    Avoid too much red meat consumption

    Beef, lamb and pork probably contribute to causing cancer according to the WHO. Use common sense, and eat more fish, chicken and turkey. Reduce your beef consumption. My grandmother said when I grew up in Germany that beef was a meal reserved for Sunday dinner only. The rest of the days we ate little in the way of meats, but lentils, beans, eggs or fish instead. Ask your grandmother, what she used to cook. Or ask your mother what she ate as a child.

    Other lifestyle issues

    Quit smoking, if you still do. This is by and large the biggest risk for developing lung cancer, throat cancer, esophageal cancer and pancreatic cancer. Watch your calorie intake: eat smaller meals more often. This way the production of your digestive juices will consume some calories and because you satisfied your hunger for foods, you will not gain weight. This will help prevent obesity and type 2 diabetes, both of which are established risks for developing cancer. Here is a review that shows you, which cancer types are caused by obesity: Obesity and Cancer . With regard to diabetes, there is a strong association with developing liver cancer, pancreas cancer and endometrial cancer (=uterine cancer). There is a lesser risk (only 1.2 to 1.5-fold) to develop colorectal cancer, breast cancer and bladder cancer. Diabetes and Cancer: A consensus report.

    Pollution can also be a factor in causing cancer: How air pollution can cause cancer. If you can move to a less polluted city, do so.

    Foods That Can Protect You From Cancer

    Foods That Can Protect You From Cancer

    Conclusion

    As shown above there is strong evidence that certain foods can cause cancer. Others, including supplements like curcumin and vitamin D3, can help prevent cancer. If we avoid as many of the known cancer producing foods and eat more of the healthy foods that do not cause cancer, our cancer risk will decline significantly. In addition, if you quit smoking, avoid pollution as much as possible, reduce your alcohol intake and watch your calorie intake to prevent obesity and type 2 diabetes, you will move into the low-risk cancer group. We all need to work on this on an ongoing basis.

    Feb
    24
    2018

    What Causes Premature Aging?

    Some people look 10 years older than their stated age, and we often wonder: what causes premature aging? Accelerated or premature aging can have a multitude of underlying causes. I will list a few here:

    1. Weakening hormones

    Men go through andropause at around the age of 60 to 65 and women go through menopause around the age of 55 to 65. In both males and females it is the sex hormones that are missing around that age. If hormones replacement follows fairly quickly with bioidentical hormones, this will not affect the visual appearance that much. In contrast, if bioidentical hormones are not the therapeutic choice for  hormone replacement, but synthetic ones, the hormones are not in balance, as synthetic hormones do not restore the hormonal balance. Nothing is gained, as the person will still age prematurely.

    Synthetic versus bioidentical hormone replacement

    In addition the synthetic hormones will cause heart attacks, strokes, clots, and cancer. Prescriptions for synthetic hormones are often the cause that the aging patient population gets these serious complications. Frequently physicians insist on using synthetic hormones from a “reputable” drug company to replace missing hormones. The reason this does not work is that a male has testosterone receptors. They need to be stimulated by bioidentical testosterone to restore all of his missing functions. Also, the same is true in menopausal females who need stimulation of their estrogen receptors and progesterone receptors. Consequently, only bioidentical hormones will return a postmenopausal woman back to normal. There is a perfect fit between the bioidentical replacement hormones and her hormone receptors. Using synthetic hormones is like trying to unlock a door with a key that does not have a perfect fit: you damage the lock!

    2. Missing human growth hormone (HGH) and thyroid hormones

    These hormones have a special place in aging.

    Human growth hormone deficiency

    First, HGH production is running out in many people at age 60. A person with HGH deficiency will have lower muscle mass and strength. Other symptoms are dry and thin skin, particularly at the back of the hands. Men are balding, and they loose interest in sex. There are difficulties concentrating and they may have “senior moments”, which are memory lapses. Often they are prone to depression and anxiety. A blood test will frequently show elevated triglycerides. A blood test (IGF-1) and a urine test exist which make it possible to look for HGH metabolites to assess whether a 40, 50 or 60 year-old person is producing enough HGH. Many may need replacement of HGH. This is administered by injection through a tiny needle into the skin, similar to a diabetic injecting insulin. This will bring back what was missing due to HGH deficiency.

    Thyroid hormone deficiency

    Thyroid hormones (T3 and T4) are other important factors that could make you look older prematurely. Your hair is getting thinner; your skin turns dry and pale. The nails may be getting brittle. When the outside half of the eyebrows is very thin or missing, this can be a sign of hypothyroidism. In a similar vein the skin in the face may be puffed up due to swelling of the layers under the skin (myxedema). It is important to diagnose hypothyroidism, which is common in the aging population. The physician needs to order a blood tests (TSH, T3 and T4). If TSH is above the upper limit, your physician needs to replace both T3 and T4 by tablets (I prefer Armour as the T3 and T4 is balanced).

    3. Smoking

    The lining of the airways absorb cigarette smoke. The chemicals circulate around in the blood and lead to aging of the skin. Chronic cigarette smoke exposure also melts away the subcutaneous tissue. The end result is a haggard look. The natural glow disappears from the skin and because of carbon monoxide binding to hemoglobin the skin color looks more greyish. In addition the blood vessels are narrowing or clogging. This means that the body cannot absorb nutrients as well, and cells are starving. There is only one remedy for this: quit smoking!

    4. Overexposure to ultraviolet light

    The radiation of UV light can penetrate deep into and under the skin. This makes the subcutaneous fat melt away. The largest UV exposure is in the facial area. As a result we see aging there. The end result is a sagging appearance of the face. This link has an image of a woman before and after a non-surgical facelift with stem cells and fatty tissue: Stem Cell Treatments That Are Currently Available – Medical Articles by Dr. Ray

    In a surgical procedure the physician harvests mesenchymal stem cells from fatty tissue by liposuction. A cell separator separates the mesenchymal stem cells, the connective tissue and the fat cells. The connective tissue is discarded. Mesenchymal stem cells and fat cells are mixed and injected into the thinned subcutaneous fatty tissue until the person’s younger facial contour is back to normal. Typically this will last for 10 years or more.

    5. Drugs and alcohol abuse

    Both can lead to malnutrition with weight loss and loss of subcutaneous fatty tissue, which causes sagging breasts in women. In men “beer tits” are common. The reason for this is estrogen accumulation, as alcohol interferes with the elimination of estrogen in the liver. Alcohol is a general cell poison. It causes all of the cells to age prematurely. The more alcohol you drink, the faster you age. The skin develops wrinkles, loss of elasticity and collagen, redness and puffiness. In other words chronic alcohol abuse ages you prematurely. The only remedy for this is to quit drinking. Some of your skin vitality may come back. Our body has an amazing capability to heal itself!

    6. Medical illnesses

    Many medical illnesses like diabetes, mental illness (depression and schizophrenia), multiple sclerosis, inflammatory bowel disease; cancer and others make you look a lot older very fast.

    I will briefly explain the reasons for this.

    • Diabetes

    With diabetes type 2 the pancreas releases too much insulin after a meal with starches and sugar; think about a sweet muffin or a toast with jam. The extra insulin causes inflammation. This stimulates enzymes that break down elastin and collagen, leading to wrinkles and sagging skin.

    • Mental illness like depression and schizophrenia

    We know from studies that depression leads to shortening of telomeres. This in turn causes cell death in the most rapidly dividing cells like in the skin and hair follicles. The end result is prematurely aged hair and skin. Schizophrenia also leads to premature shortening of the telomeres, which causes premature aging, mitochondrial dysfunction, inflammation and oxidative stress. The end result is that the person looks older than what their chronological age is.

    • Multiple sclerosis

    It is sometimes difficult to discern in patients with MS what is normal aging and what is aging from the disease. This link gives some background on this. Many MS patients are anxious, and anxiety and stress by itself also leads to premature aging.

    • Inflammatory bowel disease

    The chronic inflammation of either ulcerative colitis or Crohn’s disease can lead to premature aging. High doses of vitamin D3 and molecularly distilled fish oil can be useful to help treat the inflammation. Probiotics are also important to restore the bowel flora.

    • Cancer

    Cancer leads to cachexia (excessive weight loss). There is also excessive inflammation, which leads to accelerated aging. The inflammation causes increased oxidative stress. This leads to tissue damage and DNA damage, which makes all cells more vulnerable to develop other cancers. Oxidative stress can substantially accelerate telomere shortening. As a result skin can become saggy, wrinkles develop and the person looks prematurely aged.

    7. A chronic lack of physical activity

    People who never exercise tend to get overweight and eventually obese. This leads to premature aging. Exercise would elongate telomeres, but inactivity shortens them. Obesity leads to increased oxidative stress and to DNA damage. Obesity also shortens telomeres. All of this leads to premature aging.

    What Causes Premature Aging?

    What Causes Premature Aging?

    Conclusion

    These are only a few examples of causes of accelerated aging. The key is to stick to a healthy, balanced diet (like the Mediterranean diet) and exercise regularly. Stop smoking (if you do), don’t take street drugs, and make sure you get enough sleep. Getting enough sleep helps your hormones regenerate overnight. The sympathetic overdrive from your daily activities is counterbalanced by the parasympathetic activities during sleep that causes relaxation. For hormone replacement you may have to see an anti-aging physician, a naturopath or integrative medicine physician. This may be your only chance to address any hormonal deficiencies. Conventional medicine does a very poor job of HRT (hormone replacement therapy) with synthetic hormones. Conventional practitioners want to treat you with synthetic hormones that will make you sick. Hormones for replacement have to be bioidentical! This way you will live 10 to 15 years longer, look younger and stay healthy.

    Feb
    18
    2018

    Causes Of Back Pain And Their Treatment

    There are many possible causes of back pain and their treatment is described in this blog. I have listed the 10 most common causes of back pain below. I also added brief therapeutic suggestions.

    Facet joint disease (lower back strain)

    When there is a misalignment of the facet joints, the joint capsules of these small joints are pulled, which can cause severe back pain. Chiropractic or physiotherapy treatments initially followed by active exercises will help (facet joint pain).

    Degenerative disc and facet joint disease

    Degenerative changes of the disc material between vertebral bodies and osteoarthritis of the facet joints can cause back pain. This is due to irritation of the nerve roots. Anti-inflammatory medication and physiotherapy treatments often help; swimming will be beneficial as well. End stage intractable disease, if confined to one or two levels, may respond to fusion surgery by a spinal surgeon. While you research the surgical option, I suggest you investigate about the possibility of stem cell therapy with PRP (platelet rich plasma). This is less invasive and will likely heal better than conventional surgery.

    Spondyloarthropathies

    This is a family of chronic inflammatory joint diseases of the spine . The physician treats the underlying disease and uses anti-inflammatories to control inflammation. Most of all, a person with this condition needs a referral to a rheumatologist for more specific therapy.

    Osteoporosis

    Osteoporosis is a bone condition that can lead to compression fractures of the spine. These in turn can irritate one of the nerve roots to lea to radiating pain into one or both legs. The physician will treat the underlying hormone disbalance, if present. Regular walking and swimming are used to remobilize. Avoid alcohol, caffeine and stop smoking. Supplements like calcium, bisphosphonates, vitamin D in higher doses and vitamin K2 can help re-calcify the bone.

    Scoliosis

    Scoliosis is often congenital. This spinal curvature leads to back pain and hurts more the more the spine is curved. Treatment: bracing during growth spurts; good posture; strengthening exercises; in severe cases corrective surgery by a spinal surgeon through the use of Harrington rods.

    Spinal stenosis

    Spinal stenosis is often the end condition of severe degenerative arthritis of the spine. It is more common in the older generation. As this link explains, there is a narrowing of the channel through which the spinal cord travels. In the past decompression surgery for severe cases was the only means to free spinal cord and nerve roots. In the last few years stem cell therapy is a new addition as an alternative to orthopedic surgery. The advantage of stem cell therapy is that there is no scarring following the procedure and the stem cells function like a biological knife from inside.

     Posttraumatic fibromyalgia

    Some people develop lower back pain following traumatic injuries. Instead of resolving their muscle sprain, they end up with chronic pain. Often low dose antidepressants and cognitive therapy will help. Mild physical exercises may help to rehabilitate the patient and return to normal muscle mobility. Unconventional therapy like prolotherapy, dry-needling and low-dose laser therapy (Dr. Weber) may be useful.

    Disc herniation with or without sciatica

    With disc herniation the back pain is intense, which often prompts the orthopedic surgeon to do an early discectomy (back surgery). But long term studies have shown that only in 3% of all acute back pain cases surgery is necessary; many cases heal on their own. In this case the new regenerative medicine approach of stem cell therapy with PRP will give superb clinical results. Stem cells will rebuild the disc and also take care of any arthritis in the small joint along the spine.

    Spondylolisthesis and other congenital malformations

    There are 4 grades of slipped vertebral body diseases (spondylolisthesis), where grade IV is the most severe case. Grade I to IIIA do not need surgery, stage IIIB and IV need fusion with instrumentation by a spinal surgeon.

    Bone metastases

    In stage 4 of many cancers metastases travel through the whole body including the skeleton. The underlying cancer needs treatment, often chemotherapy is required. Unfortunately cancers with bone metastases have a very poor prognosis. Here is a link how to manage symptoms of bone metastases.

    Causes Of Back Pain And Their Treatment

    Causes Of Back Pain And Their Treatment

    Conclusion

    I have listed the ten most common ones of back pain. For muscle spasms, simple physiotherapy or chiropractic treatment are often very helpful. Early degenerative changes in joints and discs will often respond to anti-inflammatory medication. But anti inflammatory drugs can be hard on your liver and your kidneys. If your back pain is getting more chronic, your doctor may want to arrange for an MRI scan of the area that causes pain. If this shows degenerative change in the discs and facet joints it is time to contact a regenerative medicine clinic. They specialize in stem cell and platelet rich plasma (PRP) treatments. This may be what you need to restore your back to normal. Conventional surgical methods are often the choice, but they are not always successful. Surgery can leave scarring behind, which by itself can give you chronic back pain.

    Feb
    10
    2018

    What To Do To Stop Eating Junk Food

    Eating junk food is a favorite pastime in North America, so what to do to stop eating junk food? Everybody knows that it is not a good choice, and it is known that health problems have a connection to unhealthy eating habits. When you are used to eating junk food, your taste buds are accommodated to the inferior foods that you want to avoid. I would suggest you educate yourself first regarding what junk food is, and next compare it to healthy food. Junk food has additives and taste enhancers.

    Monosodium glutamate

    Monosodium glutamate is one additive that often is on the ingredient list of processed foods. This is not a harmless flavor enhancer. It belongs into the group of excitotoxins. The substance can destroy brain cells. It also has the potential to give you a nasty headache, especially if larger quantities are in the food. When we look for food, we do not want to get a headache or risk losing our memory down the road. I threw out all MSG containing foods in 2001. To make it challenging MSG comes under many disguised names: autolysed yeast, monosodium glutamate, textured protein, yeast food, sodium caseinate and others.

    Read labels and exclude products with MSG in it. It is a good investment into your future without Alzheimer’s disease or other cognitive disorders.

    Avoid refined sugar

    Next you want to make sure that sugar is excluded from your diet; with this I mean refined sugar as well as sugar from processed foods. If you read food labels, you probably are aware of how much sugar manufacturers include in processed foods. It tastes pleasing, it is cheap and it makes people come back to buy more. But you as the consumer have a right to get rid of this as it causes your insulin level to increase, and on the long term paves the way to diseases such as diabetes, cardiovascular diseases (heart attacks and strokes), Alzheimer’s disease and others. As a result I do not buy anything with added sugar.

    Use stevia instead of sugar

    If I like to sweeten my coffee or yogurt, I can do it by adding a tiny bit of stevia, a natural plant sweetener. There are no calories, there is no insulin response, no worry about diabetes or Alzheimer’s, and no tooth decay either.

    Cook more meals at home and avoid restaurants

    The more you can cook at home, the easier it is to take your lunch salad along in a BPA free container. It is better for you, better for your health, and by actively avoiding junk outlets; restaurants will get the message and offer healthier food choices down the road. It is a process of years to change consumer habits. You will be the beneficiary. Here is an example how to order food in a restaurant, if you want to make healthy choices:

    Eating out at a restaurant

    What would you like for a drink?

    The first thing the waiter will do is asking you what drinks you want to order. My answer is sparkling (or non-sparkling) mineral water. This establishes that I do not want to order alcoholic drinks or sugary sodas. They are empty calories; they are also overpriced. But if you really want to have a glass of red or white wine, make sure that you pick a good one and only one glass. Studies have shown that the resveratrol in it will prevent heart attacks, but too much of it undermines your liver and the healthy condition of your pancreas.

    The main event

    Next the waiter will come with bread and butter. It is best to skip these offerings. I just say: “Thank you, but I don’t eat bread or pasta”. As a matter of fact I usually tell the waiter when I order the mineral water that I do not want any bread. Waiters nowadays understand: no carbs! (The truth is that you do indeed eat carbs. Vegetables and fruit are low-density carbs!) It goes like a red line through the rest of the order. It starts when I order my meal: a bowl of salad as a starter is great, and next I order meat or fish with a side of vegetables. The waiter understands, and often restaurants will offer to substitute the pasta or potatoes with extra vegetables.

    Dessert anybody?

    After the meal the waiter will temptingly produce the dessert menu: any dessert today? The answer is a simple “no, not today”. After a filling meal nobody needs a dessert that is off the calorie Richter scale!

    Usually this is the blueprint for me at a restaurant. With this approach you will avoid weight gain, but you will leave the restaurant satisfied. Unfortunately these days in most restaurants we do not have any choices yet with regard to organic food. More restaurants are starting to pay attention. Again, it is consumer habits that make a change!

    At home the thought processes are very similar to eating out in a restaurant. You develop some discipline and stick to healthy foods. Avoid sugar, MSG, too many starchy foods and processed foods. Before you know it, it becomes a lifestyle that you take with you wherever you go.

    Shopping for healthy foods

    As we want to go out to restaurants less and eat at home more, it is important that I tell you how to shop. We want healthy food with no or a minimum of insecticide residues on vegetables or fruit. This is why it is important to buy a lot of organic vegetables and fruit.

    Before you start shopping I suggest you look at your fridge critically. Cut out all refined sugar and starchy foods. So you go through the content of your fridge and look at all of the labels to assess what every food contains. I did exactly this in 2001 and 1/3 of the content of my fridge had to be thrown out, as it was incompatible with a sensible diet. Not to add any additional sugar was easy, but things like jams that have 45% to 50% of sugar in them had to be removed as well. Bread had to go and all soft drinks (=sugary drinks) had to go. It was quite an eye opener.

    Maintenance of your no sugar program

    In the meantime we shop at the periphery of a grocery store as follows.

    Start at the deli: your low fat cheese varieties, roasted chicken or turkey breast or lean ham if you choose are all found here.
    Go on to the meats: lean cuts of beef, pork, chicken, lamb will be found here.
    Fish and seafood: salmon, sole, cod, halibut, trout, mussels, shrimp will be there to choose from.

    Continue at the vegetarian section: tofu, tempeh and veggie burgers. It is debatable how valuable soy products really are. About 95% of the soy crop is genetically engineered, and textured soy protein has nothing to do with a “natural” product.
    At the dairy section you will look for 1% milk, almond milk or pea protein milk, yogurt, low fat cottage cheese, and more low fat variety of cheeses.

    More shopping

    The bakery section is also at the periphery, but you will want to be very discerning, as these are products which offer not much more than dense carbohydrates, trans fats, and a lack of minerals. The dozen bagels will not offer you much nutritional bang for your buck!
    Finally you will arrive at the produce department. You will likely go for all the green leaf choices like leaf lettuce, kale, chard, spinach, as well as the cabbage varieties (broccoli, green cabbage, sui choy, napa cabbage and cauliflower).

    More shopping for the right foods

    The other ones on your list are the intensely colored non- root vegetables like tomatoes, red and green peppers, also mushrooms, which are a power house of minerals, green beans, asparagus, as well as onions and garlic. You will also buy your fruit: apples, oranges, grapefruit and other citrus, pears, berries, and pineapple. You will go easy on mango, papaya, and banana because of their high sugar content.

    The deep frozen section can be your best ally

    Look for deep frozen vegetables, fruit, and fish as well as meats. As vegetables are quickly readied for the freezer, their vitamin content can be higher than that of a vegetable that has spent 8 days in transit from the field to the produce department. The deep frozen section also gives you access to a lot of variety. You’ll be able to enjoy some strawberries, even when they are not in season. Read the labels, as some fruit have been packaged with sugar syrup. Look for the varieties, where no sugar has been added. The frozen section also contains some highly processed items: deep-fried foods and dessert selections, which may not be an accessory to full health, but rather to an empty wallet.

    Canned foods

    Canned foods can be useful, as long as you are dealing with fruit that are canned in their juices and not in sugar syrup. The vegetables are less valuable in vitamins than their deep frozen counterparts. Watch out for varieties, where less salt is added. The label will tell you” low sodium”. With canned products it is also important to pay attention to the can. Many of the cans are lined with a BPH product, which is an immune disruptor. Look out for cans, where the label clearly states that they are “BPH free.”

    Some more staple foods

    You will not have to navigate all the aisles, except for your cleaning products and your cosmetics. There are some staples, which you will also require: olive oil, some olives, almonds or macadamia nuts (raw or dry roasted). The one cereal product, which is valuable, are coarse rolled oats and some pot barley. Both varieties carry a lot of fibre, which makes them very useful food staples. Avoid the “quick cooking” or “instant” oats. Due to the processing, the carbohydrates are absorbed a lot faster and consequently trigger a higher insulin response.

    Shopping for drinks

    You will wonder about drinks next. Having passed the colas, ginger ales and other sugar sodas you may eye the diet drinks. Beware of drinks sweetened with aspartame. There is increasing evidence that phenylalanine (brand names: Aspartame, NutraSweet and Sweet’N Low) is not a “harmless” sweetener. Newer research has shown that it can cause gastroesophageal reflux (=GERD) and migraine headaches.

    Stevia, a sweetener from a South American plant, does not have harmful effects. It is safe to use as a sweetener and does not cause an insulin response. You are best served with mineral water, purified drinking water, herb teas, tea or coffee. Fruit juices do have vitamins and minerals, but they are high in sugar causing an insulin release.

    No canned fruit juices

    You would not really eat 3 large apples in one sitting. So why insist on drinking 8 oz. of apple juice? You’ll ingest all the sugar and forgo the fibre! You’ll also notice, that a lot of fruit juices have been mixed with sugar, water, artificial flavor, some color, and as an apology some vitamin C is often on the list of ingredients. They are appearing on the shelves as “a good source of vitamin C”. In reality we are dealing with flavored, colored sugar water. Use your own judgment, whether you want to spend your dollars on this selection!

    Convenience and snack foods

    In the aisle adjacent to the pop you will very likely encounter a huge selection of convenience and snack foods. They have several things in common: you have met them on TV, some will be high in starches and fat (chips), others will be high in starches, sugar, and fat (cookies, donuts, cream pastries), and we are dealing with trans fats. Do take time to read the listed ingredients, and then decide, whether you and those who eat in your household deserve nutritional garbage. You have now completed your round trip in the supermarket.

    Summary of your round trip in the supermarket

    To sum up the most important facts, remember the following:

    • Do most of your shopping at the periphery of the store.
    • Look for fresh products – the less processed, the better.
    • Read the ingredients on labels.
    • Stay away from nutri-garbage
    • Buy the majority of your fruit and vegetables as organic produce. There are exceptions like raspberries, blackberries, asparagus, avocado where the regular produce is clean. But strawberries, bell peppers, broccoli, celery, grapes, spinach and tomatoes are all part of the crop that has been sprayed. Beware of the “Dirty Dozen“!
    What To Do To Stop Eating Junk Food

    What To Do To Stop Eating Junk Food

    Conclusion

    When you cut out junk food and adopt healthy food habits , you will loose a few pounds, which is natural. The sugar and starchy food you cut out had calories that you are no longer consuming. This makes you loose some weight. But you will feel more energy, because you are feeding your body what it needs. You no longer get those hypoglycemic episodes that made you tired before. Essentially you switched from the Standard North American diet that includes junk food to a Mediterranean-type diet. This type of a diet has been found to be anti-inflammatory. It prevents arthritis, diabetes, heart attacks and strokes. It may also prevent some cancers, but various studies on cancer get different results. If you follow this type of a diet without junk food you will live a longer life and stay healthier.

    Feb
    03
    2018

    Drugs Are Not An Escape

    We have a drug epidemic, but drugs are not an escape. Along with this epidemic there have been thousands of lethal overdoses. I like to review why so many people use street drugs or prescription pain pills. It started years ago with heroin injections had become more popular. But then heroin was getting a bad name, it became illegal, and prescription pain pills replaced heroin. Percocet, OxyContin and morphine prescriptions took off. Together with it the number of people with addiction increased drastically. The latest fashion craze is Fentanyl.  Fentanyl works faster than morphine, but also wears off faster. One of the deadly side effects is respiratory depression. This  means that a person cannot breathe and as a result will die. This is what is happening right now and what creates the news headlines.

    Pain receptors

    There are pain receptors all over the body, in muscles, organs and the skin. They are called nociceptors. Many medical conditions lead to pain in various parts of the body. For instance, with end stage degenerative arthritis bone rubs on bone. This causes a lot of pain in joints like the knees or the hips. Physicians often prescribe narcotics like OxyContin to control the pain. It may help for some time. But after a few weeks patients complain that the strength of OxyContin has worn off. The same dosage that gave them relief from the pain initially just does not give them relief any more. This observation is crucial. It is exactly what people who use OxyContin as illicit street drug found as well. The drug wears off, because the opioid receptors are getting weaker.

    Pain receptor resistance

    Nociceptors or opioid receptors are pain receptors. These receptors report pain to the body, and they have connections through the spinal cord to the brain. When an opioid is interacting with the pain receptor it inhibits acute pain to a large extent. But when the pain becomes chronic, the pain receptor is not working as well. More and more of the pain medication is necessary to achieve pain relief.  Eventually the opioid medication is not working to relieve pain any more. The name for this phenomenon is “pain receptor resistance”. Scientific work behind why pain receptors get lazy in responding to opioids is still ongoing. In the meantime it simply is an observation. This is the reason why drug addicts are tending to increase the dosage of OxyContin or of Fentanyl. The toxic threshold of Fentanyl that is exceeded in the process is the reason for the deaths.

    Insulin resistance

    You may have heard of insulin resistance in diabetics. This is a very similar problem. With insulin resistance the diabetic no longer has a 100% response to insulin. This means that blood sugar is not going through cell membranes effectively as it should when the insulin receptor is working. The blood sugar values stay high and make the diabetes worse.

    With pain receptor resistance the opioid is not giving the relief from pain it used to give. No wonder that the patient is feeling frustrated that the pain medication is no longer working properly.

    Therapeutic index

    The layperson does not normally know that there is a dosage for any drug where it becomes toxic. There is also a lower dosage where the drug is becoming effective. The difference between the two dosages is the “therapeutic window” or the “therapeutic index”.

    Morphine has a therapeutic index of 70:1. Compare that to alcohol with a therapeutic index of only 10:1. Fentanyl has a therapeutic index of 300:1.

    The danger of Fentanyl

    One would think that Fentanyl should be safer than morphine, because the therapeutic index is larger. But the onset of Fentanyl is much faster than that of morphine and by the time drug users take Fentanyl they often are desperate for the drug to take their pain away and they overdose, which causes respiratory depression. If they are not intubated by an anesthetist and connected to artificial respiration, they die very quickly. Janssen Pharmaceutica first developed Fentanyl in 1959. Fentanyl was strictly part of the pre-anesthetic medicine for patients before going into surgery requiring a general anesthetic. The anesthetist was right there and would intubate the patient. That’s why we never heard of deaths from Fentanyl in the past.

    If a person gets no pain relief from any opioid because of receptor resistance, the tendency is to increase the dosage. But this is what pushes the person into toxic ranges and this is what causes death from inadvertently suppressing the ability to breathe. People can get into trouble with alcohol overdoses, but the ordinary person usually knows how to handle alcohol. Fentanyl is a lot different due to the fact that respiratory depression (not being able to breathe) is one of the early symptoms that hits you suddenly.

    What drugs do to your brain

    Dr. Daniel Amen, a psychiatrist and brain researcher has used SPECT brain scans to produce images of different clinical conditions. This link shows the effect of a stroke, of Alzheimer’s disease and of drug abuse on the brain. Dr. Amen says that a brain can be rehabilitated. He has other SPECT images showing the images of an addicted brain and that of a rehabilitated brain. Spect scans are expensive.  But they may be worth it, to impress a drug addict to stop the drugs and get rehabilitated.

    Big Pharma and opioid drugs

    In 1995 the FDA approved the use of OxyContin for chronic pain. Perdue Pharma, the drug company that had developed this opioid convinced the FDA that OxyContin stayed in the blood for 12 hours and they claimed that by being active longer than other opioids this would lead to better pain control and less addiction. It turns out that this was a slick sales pitch, however it was not true. Pain receptor resistance is as much a problem with OxyContin as with any other opioid. And the drug is as addictive as all the others. But the problem is that the FDA had approved OxyContin. What’s more, Purdue Pharma sent aggressive drug representatives to all the practicing physicians misleading them as well as the FDA that OxyContin would not be as addictive as other opioids.

    Penalty for misrepresentation of OxyContin

    In 2007 Purdue Pharma had to pay a fine of 634 million $ for misrepresenting the addiction potential of OxyContin. But the drug company was allowed to continue to market OxyContin. Since 2015 Purdue Pharma has been cashing in 2.4 billion $ annually from the sales of opioids including OxyContin. In the meantime Fentanyl, despite its danger of suppressing the ability to breathe, has taken off with regard to sales. Fentanyl also has taken over in terms of causing deaths across the US and other countries.

    Alternative treatment of pain

    According to Ref. 1 chances are that 70% of patients with back pain will get better with a few visits to an acupuncturist. In 1972 Dr. Ulett’s laboratory at the University of Missouri succeeded in getting the first NIH research grant for the study of acupuncture in the US. During these studies they found remarkable facts, the most important perhaps that electrical stimulation of acupuncture needles resulted in a doubling of the effectiveness of traditional Chinese acupuncture. After extensive research Dr. Ulett stated: ”The ancient practice of traditional Chinese acupuncture is now obsolete” (Ref.1). in the meantime the more effective electro-acupuncture has replaced acupuncture needles with the use of electrical skin pads.”

    Other applications for electroacupuncture

    Beside pain relief many other applications exist for electro-acupuncture. Addiction medicine makes use of electro-acupuncture in weaning people from morphine or heroine etc. It is effective to treat psychiatric illness, particularly depression. It is useful in relieving nausea and vomiting due to chemotherapy with cancer treatments or associated with pregnancy without affecting the pregnancy.

    Prolotherapy

    Prolotherapy has been successful for the treatment of back and neck pain, for arthritic pain and pain from chronic muscle spasm. When prolotherapy is done by itself 12.5% Dextrose is injected into the area of injury. Dr. Fields said that the reason it works is that there is activation of local stem cells in the injured area in the area of the Dextrose injection site. These stem cells will do the healing (details explained in an interview with Dr. Reeves). Further improvement of this technique and better results are possible by injecting a small amount of platelet rich plasma (PRP) very focally to an area of ligament rupture. PRP is obtained by centrifuging blood from the patient’s vein. The red blood cells are not necessary, but the platelet fraction and some of the plasma are part of the the PRP preparation.

    It is often striking how much pain control occurs after only one or two prolotherapy treatments.

    Stem cell therapy with PRP and low-dose laser therapy

    This is a more direct way to get stem cells where the doctor wants them to do their work. Stem cell therapy with PRP and low-dose laser activation is the latest in terms of controlling pain. At the 22nd Annual Anti-Aging Conference in Las Vegas (Dec.10 to 14, 2014) Dr. Purita gave an overview of this method of pain control. He discussed the importance of the proper harvesting of PRP. He explained that apart from white blood cells (WBC) and platelets an important component of PRP are very small embryonic like stem cells (VSELs). They are visible through the microscope. The missing link has been the observation that white blood cells produce inflammatory substances, which have been detrimental in stem cell injections with PRP in the past. There was a poor survival rate of stem cells.

    Low dose laser activation of stem cells and PRP

    Photo-activation of the PRP before injection leads to anti-inflammatory behavior of the WBC in PRP. Dr. Purita calls this “light activated PRP”, which leads to the best results with stem cell/PRP injections.

    Soft laser stimulation with red, green and blue soft lasers have also been effective to improve tissue healing significantly when stem cells and PRP are used together with light activation. The main sources for good stem cells are the fat tissue (from the “love handles”) and the bone marrow (obtained from pelvic bone). The stem cells mesenchymal stem cells (from fatty tissue) and bone marrow stem cells. The mix of all of this can mend osteoarthritic joints, degenerative disc of the spine, in short all musculoskeletal injuries that may be painful. The hallmark of healing with stem cells is that chronic pain disappears.

    Curative treatment versus symptomatic treatment

    It is one thing to treat a patient for pain symptomatically by prescribing OxyContin or other opioids. It is a completely other thing when the physician cures the pain by one of these alternative methods. Let us assume that a patient has a fall of a few step from a ladder and sustains a contusion of the lower back. This can be painful and may require a few pain pills. But if it does not improve within one week and diagnostic tests show that there is no fracture, electroacupuncture may be the solution to treat the pain rather than the use of an opioid. If this does not help, consider the combination stem cell/PRP/low-dose laser therapy. Chances are better than 80% that this will help. The patient will no longer suffer of pain. With healing life can go on: no pain pills. No addiction. No death.

    Drugs Are Not An Escape

    Drugs Are Not An Escape

    Conclusion

    Conventional medicine treats pain symptomatically instead of treating the cause. It gets the physician to prescribe opioids, which can be the beginning of a series of tragic events. It can lead to drug addiction, dose acceleration, toxic effects of opioids including possible death through asphyxiation from no longer being able to breathe.

    Stem cell therapy

    The physician who concentrates on treating causes will use alternative methods to treat pain. The most effective of these methods is stem cell therapy. It is a mixture of adipose mesenchymal stem cells with bone marrow stem cells that are part of the therapy. The addition of platelet rich plasma is another part of the mix, and the final step is activation of stem cells with low-dose laser therapy. The cell mix is injected in the critical area. The end result is that the patient’s pain disappears, and it leads to a cure. The only situation where short-term opioids are justifiable is following surgical procedures. But even in these cases the narcotics should only be necessary for a few days to avoid serious side effects.

    Reference 1: George A. Ulett, M.D., Ph.D. and SongPing Han, B.M., Ph.D.: “The Biology of Acupuncture”, copyright 2002, Warren H. Green Inc., Saint Louis, Missouri, 63132 USA

    More info about electroacupuncture: http://www.askdrray.com/electro-acupuncture-twice-as-effective-as-conventional-acupuncture/

    More about prolotherapy stem cell therapy: http://www.askdrray.com/prolotherapy-and-stem-cell-therapy/

    Jan
    27
    2018

    Bacterial Toxins Threatening The Brain

    Dr. Robert G. Silverman gave a talk about bacterial toxins threatening the brain. He spoke at the 25th Annual World Congress on Anti-Aging Medicine in Las Vegas on Dec. 15, 2017. First of all, he pointed out how changes in the gut flora can affect the integrity of the gut wall. In addition this can eventually this lead to a leaky gut syndrome. But it does not end here. As a result the toxins enter the blood stream and affect the blood/brain barrier. Consequently in the end various neurological diseases can develop from this.

    Here I am giving a brief overview of the talk by Dr. Silverman. But he was not the only one speaking to this subject. Several other speakers also brought up this subject throughout the conference. They stressed the importance of rectifying any gut dysbiosis to stop leaky gut syndrome and a leaking blood/brain barrier.

    Leaky gut syndrome

    When the gut flora changes there are often enteropathogenic E. coli strains, Shigella and Salmonella that invade the lining of the gut causing leaky gut syndrome. When toxins enter the blood stream, the body is starting to form antibodies against various proteins. Antibodies are acting against various targets: bacterial cytotoxins, cytoskeletal proteins, tight junction proteins and food antigens. Lipopolysaccharides (LPS) from toxins of gram-negative gut bacteria can also leak into the blood. This affects key organs like the liver, the heart, lungs, the joints, the immune system and the thyroid. When this process has gone on for some time, the blood/brain barrier is breaking down next. The intestinal inflammation causes the release of inflammatory cytokines that circulate in the blood stream. The cytokines cross the blood/brain barrier and activate the support cells in the brain, called microglia. This in turn causes inflammatory degenerative changes in the brain.

    Blood/brain barrier

    LPS circulating in the blood from gut bacteria endotoxins increase the permeability of the blood/brain barrier. This is bad news for the brain as it becomes vulnerable to attacks from the antibodies mentioned and from food particles. Dr. Silverman cited papers showing that circulating antibodies that cause inflammation in the brain can be the starting point for early Parkinson’s disease. Autoimmune antibodies can cause even depression.

    Intestinal permeability can be assessed by various antibody constellations. For instance IgA antibodies point to an ongoing issue/early leaky gut syndrome. IgM antibodies indicate early onset and IgG antibodies chronic issues of leaky gut syndrome. If you add various antigens like LPS, zonulin and actomyosin you can pinpoint which structure of the gut wall is affected by leaky gut syndrome, and the antibody type adds more information about the timing of the onset of leaky gut syndrome.

    Bacterial toxins threatening the brain when BBB damaged

    As I already mentioned the blood/brain barrier (BBB) is often simultaneously affected when there has been leaky gut syndrome. There may be a delay, but eventually the BBB breaks down also, and the brain will be in jeopardy. Dr. Silverman gave an example of how depression can develop as result of a breakdown of the BBB. Chronic intestinal inflammation can suppress the sensitive hippocampus cells from regenerating. Physicians call that impairment of hippocampal neurogenesis. Inflammatory cytokines damage the neuronal cell progenitors. As a result patients with inflammatory bowel disease can have mood disorders and cognitive impairment. Sophisticated BBB blood tests can pinpoint whether the BBB is intact or establish whether there is impairment. The important thing to remember: there is a gut brain connection.

    Fixing the gut to stop bacterial toxins threatening the brain

    In order to fix the BBB, you must first concentrate on fixing leaky gut syndrome.

    • Avoid gluten, as gluten is causing inflammation of the gut wall.
    • Start taking probiotics that contain more than 30 Billion lactobacillus plantarum, lactobacillus acidophilus and Bifidobacterium lactis per daily dose.
    • Do a heavy metal detox involving phytonutrients, hops, turmeric, Andrographis, zinc, polyphenols, omega-3 fatty acids, and watercress plant extract. Andrographis, also known as the “King of Bitters”, is an Ayurvedic medicine used to promote digestion and stimulate appetite.

    Nutrients to fix the blood/brain barrier

    Dr. Silverman uses the following nutrients to repair the blood brain barrier.

    • Acetyl L-Carnitine: this helps to protect the mitochondria from oxidative damage
    • Berberine: reduces inflammation in brain injuries
    • Alpha-lipoic acid: preserves the integrity of the BBB by controlling oxidative stress
    • Curcumin: decreases brain swelling, preserves the BBB and increases tight junction protein in brain cells
    • Vitamin D3 (5000 IU or more): protects the BBB by various mechanisms
    • Omega-3 fatty acids: they increase cell membrane fluidity and protect the BBB
    • Resveratrol: reduces inflammation and restores the BBB

    Neuroplasticity

    In order for the brain to adapt to changes, it must be flexible, which means on a cellular level that nerve cells form new synapses, neurological pathways etc. This is what neuroplasticity means. Here are the factors that Dr. Silverman listed as facilitating neuroplasticity.

    • Regular exercise
    • DHA from fish oil capsule supplements
    • Turmeric
    • Whole coffee extract
    • Alpha-lipoic acid
    • Lactobacillus brevis and Bifidobacterium longum
    • Bifidobacterium animalis Lactis 420 (B420)
    • Probiotics: they feed the healthy gut bacteria (e.g. apple cider vinegar)
    • Elevate magnesium in the brain through L-threonate
    Bacterial Toxins Threatening The Brain

    Bacterial Toxins Threatening The Brain

    Conclusion

    In the last few years it has become abundantly clear that leaky gut syndrome is not an isolated matter. It is invariably connected to a breakdown of the blood/brain barrier (BBB). Leaky gut syndrome alone is bad enough as it can lead to a number of autoimmune diseases, like Hashimoto thyroiditis and others. But when the BBB is affected, antibodies can now affect nerve cells, can cause Parkinson’s disease, depression, and even Alzheimer’s disease. There is no reliable database for what can happen to the brain when the BBB breaks down.

    Because of these connections it is important to sanitize the gut, re-establish a healthy gut flora and overcome leaky gut syndrome. This will at the same time repair the broken down BBB. It will also prevent further possible damage to the brain in the future. Your gut health is your brain health. Take care of both your gut as well as your brain!

    Jan
    20
    2018

    Lower Cholesterol

    When your cholesterol is high, what can you do to lower cholesterol? First, there is the bad cholesterol, called LDL cholesterol that should not be too high. Furthermore, there is the good cholesterol, called HDL cholesterol that you want to be to higher to protect you from hardening of the arteries. LDL cholesterol finds its way into plaques of arteries, and later calcification occurs. HDL cholesterol does the opposite; it dissolves LDL cholesterol and brings it to the liver.

    Food contributes only to a small portion to the increases of your LDL cholesterol (the bad cholesterol) in the blood. The minor part of the body’s cholesterol stems directly the refined carbs and trans fats from your diet. Here are a number of steps that will protect your heart from LDL cholesterol.

    1. Cut out red meat

    Cutting out red meat (like beef, pork and sausages) to an absolute minimum, for instance once per week or less is important. The reason is that these meats have more cholesterol in them and also more saturated fats than any other foods. Compare that to poultry, fish and vegetables like beans, which are healthy food sources.

    2. Eliminate trans fats

    We need to eliminate trans fats as they are causing heart attacks. There is an important difference between ruminant trans fats and artificial trans fats. Ruminant trans fats have been part of the human diet for millennia like milk fat and fat from cows that are on pasture and lamb. Milk products for instance contain fat with 2-5% natural trans fats. 3-9 % of the fat in beef and lamb consists of natural trans fats. Studies have shown that the body is able to handle these natural trans fats and heart attacks are not more frequent in people eating moderate amounts of these products including butter from cows that graze on pasture.

    Artificial trans fats

    Quite the opposite is true for artificial trans fats in margarine that comes from vegetable oil. Avoid bakery items like sweet pieces or muffins and other products that contain hydrogenated oils. Read labels! Use olive oil or coconut oil, but avoid vegetable oils like corn oil, safflower oil or grape seed oil to get away from trans fats and unstable oils that turn rancid. Rancid oils contain free radicals that oxidize LDL cholesterol and attack the lining of your arteries.

    3. Cut out sugar and starchy foods

    You need to cut out sugar and starchy foods because these will raise your LDL cholesterol and triglycerides, which also leads to hardening of your arteries. This is an important observation. Starchy foods are broken down by  pancreatic juices into sugar, which enters your blood stream, causing an outpouring of insulin from the pancreas. When the short-term storage of sugar as glycogen is exhausted in muscle and liver tissue, the liver has to process any surplus of sugar that is still there. The end results are triglycerides and LDL cholesterol. Unfortunately the protective HDL cholesterol does not reach higher levels, when the LDL cholesterol is increased. A persistent diet of high-refined carbs will increase the risk for heart attacks and strokes. It follows from this that we are all better off cutting out sugar and starchy foods from our food intake.

    4. Increase your soluble fiber intake

    Increase your soluble fiber intake by eating vegetables, oats and oat bran, lentils, fruits and beans. Why does this decrease LDL cholesterol? The liver tries to eliminate too much cholesterol by binding it to bile salts and excreting it into your small bowel. But the last part of the small bowel reabsorbs some of these bile salts , and from there they return to the liver. This is called the enterohepatic pathway of bile salts. Soluble fiber intake binds those bile salts and prevents re-absorption in the enterohepatic pathway, eliminating cholesterol safely in stool. Soluble fiber from psyllium, pectin, beta-glucans and others have been shown in clinical trials to reduce LDL cholesterol by binding bile salts in the gut (interrupting the enterohepatic pathway).

    Plant sterols and fiber supplements

    Plant sterols (usually sold as sterol esters) are recognized by the FDA as reducing the risk of coronary heart disease, if taken in high enough amounts (2.4 grams of sterol esters per day). There are other useful supplements like artichoke extract, pomegranate, soy protein, Indian gooseberry (Amla), garlic and pantethine (vitamin B5) that are beneficial in terms of prevention of heart attacks and strokes. It would be too lengthy to get into more details here.

    5. Take a whey protein supplement

    There are two major milk proteins, whey and casein. Only whey protein binds to total and LDL cholesterol, lowering both. It is available in health food stores. Follow the package insert of the whey product for dosing.

    6. Increase your omega-3 fatty acid intake

    Omega-3 fats are healthy fats naturally present in fish oils and nuts. They increase the amount of circulating HDL cholesterol, which binds the bad LDL cholesterol. Go ahead and eat salmon, herring and mackerel as well as walnuts, ground flaxseeds and almonds. You can also take molecularly distilled (or pharmaceutically pure) EPA/DHA supplements. This pure form of fish oil is free of mercury and other heavy metals. EPA stands for eicosapentaenoic acid or omega-3 fatty acid. DHA is the acronym for docosahexaenoic acid, an important supplement for the brain. Tests have shown that fish oil supplements at a dosage of 3.35 grams per day of EPA plus DHA reduce triglycerides by up to 40%, equally to Lipitor or even more effective, but without the statin side effects. The end result is that your total cholesterol/HDL ratio decreases. This reduces the risk for heart attacks and strokes.

    7. Eat foods with anthocyanin

    In a 24-week study with diabetic people HDL levels rose by 19% when food was eaten that was rich in anthocyanin. This consisted of eggplant, purple corn, red cabbage, blueberries and blackberries. The advantage of raising the HDL cholesterol level is that the total cholesterol to HDL ratio decreases, which lowers the risk for heart attacks and strokes.

    8. Exercising regularly

    Exercising will increase your HDL cholesterol, which again decreases the ratio of total cholesterol to HDL cholesterol. This number should be between 1 and 3.5, the lower, the better.

    9. Take a supplement called Ubiquinol, or Co-Q-10

    Adults above the age of 60 need 400 mg once daily, younger people need between 200 mg and 300 mg daily. Co-Q-10 prevents oxidation of LDL cholesterol, which would aggressively attack the arterial walls causing hardening of the arteries. What causes oxidation of cholesterol? The answer is clear: fried foods like french fries or deep fried chicken will lead to oxidation; other culprits are margarine, commercially baked goods and cigarette smoking.

    10. Calcium and vitamin D3

    Recently a study on postmenopausal and overweight or obese women found that supplements of calcium combined with vitamin D3 lowered cholesterol.

    11. Polyphenols

    Flavonoids are the largest group among the polyphenols  in such common foods as vegetables, fruits, tea, coffee, chocolate and wine. Over 130 studies on humans have shown improvement of the lining of the arteries (endothelial functioning) and lowering of blood pressure. Polyphenol consumption has a connection  to a lower risk of mortality from heart attacks. Eat a Mediterranean type diet or a DASH diet, and you will automatically get enough polyphenols with your food. However, resveratrol, the powerful red wine polyphenol, warrants a separate daily supplementation as it prevents LDL oxidation in humans (Ref.1). Take about 250 mg of resveratrol daily.

    12. Niacin/ nicotinic acid

    This supplement comes as “flush-free niacin” and also as extended release niacin; it can raise the beneficial HDL cholesterol by 30 to 35% when patients take higher doses of 2.25 grams per day. In a metaanalysis of 7 studies researchers found a significant reduction of heart attacks and transient ischemic attacks (precursor syndrome before developing a stroke). Niacin can change the small particle LDL into a large particle size LDL, which is less dangerous. Niacin also reduces oxidation of LDL, which stops the atherosclerotic process. For a healthy person 500 mg per day of flush-free niacin is adequate.

    13. Curcumin

    This is a powerful heart and brain protector combining three different mechanisms in one; it is reducing oxidative stress, is an anti-inflammatory and counters the process that threatens to destroy the lining of the arteries. One study on healthy volunteers showed reduction of 33% in lipid oxidation, a 12% reduction of total cholesterol and an increase of 29% of the protective HDL cholesterol when patients took 500 mg of curcumin for only 7 days (Ref.1). This is the daily dose I would recommend for prevention of heart attacks and strokes.

    14. Vitamin E (tocopherols)

    This fat soluble vitamin is an antioxidant and in the past knew about its use as being heart supportive. Strangely enough some conservative physicians bad-mouthed this vitamin. In the meantime health practitioners have returned to using the vitamin. It turns out that there are 8 different types of tocopherols, with the alpha tocopherol being the best-known, but you also want to be sure that you are getting gamma tocopherol with your balanced vitamin E supplement every day. It remains the one that is a powerful anti-inflammatory. Simply ask staff at your health food store for a vitamin E supplement with gamma tocopherol in it. Take 400 IU per day (of the mix).

    Lower Cholesterol

    Lower Cholesterol

    Conclusion

    There is a lot you can do to control your cholesterol level by changing your diet, shedding some pounds, exercising and quitting smoking. All this will contribute to lower cholesterol. This will have a beneficial, long-term effect regarding prevention of heart attacks and strokes. In addition there are specific supplements and vitamins, which prevent heart attacks and strokes as well. With these measures the majority of people with high LDL cholesterol can change their cholesterol levels without taking statins. Statins have serious side effects like Alzheimer’s disease and a painful muscle condition called rhabdomyolysis. None of the other measures described here have any such side effect. Even if you chose to only concentrate on a few of these 14 points to lower cholesterol there will be significant improvements in your LDL and HDL cholesterol levels, when you ask your doctor to order these blood tests.

    More info: http://www.askdrray.com/statins-can-hurt-the-consumer/

    References

    Ref. 1: Life Extension: Disease Prevention and Treatment, Fifth edition. 130 Evidence-Based Protocols to Combat the Diseases of Aging. © 2013

     

    Jan
    13
    2018

    Immune Support For Cancer Patients

    Immune support for cancer patients is necessary when their platelets are decreasing from chemotherapy. Dr. John L. Hall gave a talk at the 25th Annual World Congress on Anti-Aging Medicine in Las Vegas, Dec. 14-16, 2017. He pointed out that when cancer patients receive chemotherapy their platelet counts in the blood decline. Dr. Hall participated in a 2010 study that investigated the use of RNA fragments to protect stem cells in the bone marrow from chemotherapy. The study showed how  fragments coming from E.coli protected patients’ bone marrow cells. This immune support for cancer patients allowed physicians to carry on with regular dosing of chemotherapy treatments for the patients’ cancer. There was no dosage reduction necessary and no interruption of the treatment schedule. The optimal dose was 80mg sublingually of RNA derived from E. coli, and patients self-administered the dosage every other day.

    Low platelets mean bleeding

    Normally patients would bleed or bruise easily when they received chemotherapy without protection by RNA fragments. There would be frequent nosebleeds, bleeding in the gums or in the mouth. Patients would also have blood in urine and get petechia on their skin.

    Consequences of low platelet count on cancer patients

    There are several consequences for cancer patients, when their platelets are low with chemotherapy.

    • Patients with low platelets have fatigue
    • They experience limitations with regard to physical function
    • When platelets are low, patients need platelet perfusions
    • There is compromise of their cancer treatment because chemotherapy needs adjustment of  or the dosage, or the therapist needs to postpone further treatment.
    • Their survival rates are lower due to cancellation of chemotherapy treatments
    • More medical resources are necessary because of platelet transfusions

    How do RNA fragments work?

    RNA fragments act as primers triggering DNA synthesis in bone marrow stem cells. Fragmented RNA is also protective of bone marrow cells when the patient receives chemotherapy. In animal experiments, where toxic chemotherapy was given, fragmented RNA allowed these animals to survive. This prompted oncologists to introduce this treatment modality into end stage cancer patients who are receiving chemotherapy. Results were stunning. The patients from age 18 to 80 tolerated the RNA fragments well. They were able under the influence of the RNA fragments to continue with their regular chemotherapy to completion of the therapeutic course. When laboratory tests measured platelets, the results were normal. The investigators concluded that the RNA fragments protected the bone marrow stem cells of platelets.

    The tumors in this trial involved pancreatic cancer, head and neck cancer and cancer of the breast. In addition physicians also treated colon cancer, esophageal cancer and lung cancer .

    More details about RNA fragment therapy in cancer patients requiring chemotherapy

    Cancer patients who had no protection by RNA fragments had platelet levels that became lower and lower with every chemotherapy treatment cycle. Some patients never returned to normal platelet levels even once the chemotherapy stopped. Other cancer patients’ platelets took month before they returned to normal. Patients in this group either needed to either reduce  their chemotherapy dosage or put treatments on hold. Alternatively their treatment stopped prematurely.

    In contrast patients whose bone marrow received protection by RNA fragment therapy had stable platelet levels. Their platelet levels recovered quickly to normal after each cycle of chemotherapy. No unplanned chemotherapy reduction was necessary and no platelet transfusions were required. All the patients were able to complete the treatment plan.

    The physicians also observed that with RNA fragment therapy the peak platelet counts were still in the normal range despite chemotherapy. When patients recovered from the chemotherapy effect the platelets stayed in the normal range.

    Insulin potentiation therapy

    Research has shown that cancer cells have more insulin receptors than normal cells. Physicians used this fact  with a form of chemotherapy where the patient receives small doses of insulin first. Following that the patient can receive lower doses of chemotherapy. Dr. Donato Perez Garcia MD is the inventor of the insulin potentiation therapy (IPT). With this treatment the patient can receive lower than normal chemotherapeutic agents , which reduces the toxic side effects of chemotherapy. Unfortunately the side effect of the lower dose of chemotherapy still hits the bone marrow. As a result the platelets are dangerously low. Dr. Hall mentioned that RNA fragments are also effective with insulin potentiation therapy. This keeps the platelets in the normal range and patients can complete the course of insulin potentiation therapy.

    More background about the insulin potentiation therapy

    Dr. Robert Baratz has reviewed the merits of IPT thoroughly. He came to the conclusion that the so-called research about the effectiveness regarding IPT has not been done properly. In his opinion it is not proven that less chemotherapy is required when pretreatment with insulin has been done. There are also dangers that connect with insulin therapy. If the insulin dosage is too high blood sugar will go into dangerously low levels. The FDA has never accepted that the IPT procedure would be superior to standard chemotherapy. However, regardless of the chemotherapy dosage these chemicals are bone marrow toxic. Particularly the toxic effect on stem cells of platelets will cause diminished platelet counts in the blood with both procedures. In both cases RNA fragment therapy will overcome the toxic effect on the bone marrow stem cells.

    Immune Support For Cancer Patients

    Immune Support For Cancer Patients

    Conclusion

    Bone marrow suppression by chemotherapy has been a limiting factor for many years prior to the detection of RNA fragment therapy (RFT). RNA for RFT is derived from E. coli cultures. RNA fragments act as primers triggering DNA synthesis in bone marrow stem cells. This leads to the production of platelets that protect the patients from the toxic effects of chemotherapy on bone marrow. RFT allows the patient to receive treatment with chemotherapy without having to worry about bone marrow toxicity. No chemotherapy dose reduction is necessary and no platelet transfusions are needed. RFT should be a regular accompaniment to chemotherapy treatments for any cancer patient.

    Jan
    06
    2018

    Lyme Disease The Great Imitator

    Dr. Pamela Smith talked about Lyme disease the great imitator when she gave a presentation. This was at the 25th Congress of the American Academy of Anti-Aging Medicine, Dec. 14-17, 2017, which I attended. Dr. Smith gave a talk about how to approach a complex patient when multiple systems are affected. Part of that talk dealt with Lyme disease, which I will review below in some detail.

    Transmission of Lyme disease

    Lyme disease is one of the fastest growing infectious diseases in the US. As a result about 200,000 new cases of Lyme disease occur in the US every year.

    The transmission occurs through ticks that that carry a spirochete, called Borrelia burgdorferi.

    This bacterium, much as syphilis, which also is caused by a spirochete, produces imitator disease patterns. Clinically it can be a challenge to diagnose Lyme disease.

    The common way of transmission to humans is by infected ticks that bite the skin. But Dr. Smith said that transmission of the spirochete can also occur by breastfeeding, blood transfusions, in vitro fertilization and finally by sex. Although originally Lyme disease infected ticks were found on deer, other species can also be carriers. Ticks from mice, foxes, raccoons, songbirds, chipmunks, and squirrels can also transmit Lyme disease.

    Clinical presentation of Lyme disease

    Only 30 – 40% of adults with Lyme disease have the characteristic rash of the “bull’s-eye lesion” (erythema migrans). With children this presentation is even less common (only 10% have erythema migrans). If there is a bull’s-eye lesion, this will last from one week to several months. A laboratory test using an enzyme-linked immunosorbent assay (ELISA test) can confirm the diagnosis of the disease.

    Disseminated early or late Lyme disease

    Fatigue, headaches and weakness can be non-specific symptoms of Lyme disease. Furthermore, other non-specific symptoms like back pain, muscle and joint pains as well as chills can detract the physician from diagnosing Lyme disease. In addition irregular heartbeats, nausea, vomiting, swollen lymph glands, memory loss, gait problems, bladder and kidney problems are other symptoms. Finally, liver problems, sore throat, fever, seizures, depression, dementia, hallucinations, mood swings and arthritis can be other symptoms.Even eating disorders, verbal aggression, schizophrenia and suicide can be symptoms of Lyme disease.

    Common symptoms that have a link to Lyme disease

    Common symptoms of Lyme disease include headaches, fatigue, joint pain and swelling of joints, stiffness of the neck or back. There can be difficulties with concentration, speech or writing. Further symptoms are sleep disturbances, numbness or tingling of arms or feet and forgetfulness. 

    Lyme disease development

    Borrelia burgdorferi can be found inside body cells and outside of cells as biofilms. This form makes them resistant as it allows Borrelia burgdorferi to exchange DNA and makes them resistant to antibiotics. There are also two major forms of Borrelia burgdorferi, namely cell-wall forms and cystic forms. Once the patient has been bitten by the infected tick Borrelia can quickly change shape into the more difficult to treat cystic form. Within 24 hours Lyme disease can spread to other parts of the body. Common such areas are the eyes, brain tissue and glial cells, heart, collagen, synovial fluid of joints and skeletal muscle fibers.

    Lyme disease can also complicate many other diseases. These are ALS, Alzheimer’s disease, fibromyalgia, MS, bipolar disorder, neurological disease, heart disease (Lyme carditis) and autism.

    Treatment of Lyme disease

    1. Dr. Smith said that Lyme disease is often complicated by dysfunctional gut flora. She prefers to start patients on a sugar-free and gluten-free diet. The patient also has to take probiotics.
    2. 75% of Lyme disease patients show a cure after three weeks of Doxycycline 100 mg twice per day. Alternatively cefuroxime 500 mg twice per day is a medication of choice.
    3. Cefuroxime only treats the cell‐wall forms. Doxycycline treats the intracellular forms. Metronidazole or tinidazole will help to eradicate the cystic forms of Lyme disease.
    4. Grapefruit seed extract is another treatment modality if the patient is allergic to Metronidazole. It eradicates the cystic form of Lyme disease.
    5. Serrapeptase from whole leaf stevia extract will also help to eradicate Borrelia biofilms and persisters.
    6. Monolaurin, a coconut oil extract is effective in treating all three morphological forms of Borrelia burgdorferi.

    Patients with neurological symptoms

    Patients with neck stiffness, headaches or neuropathy need treatment for a longer period of time. These patients also need monitoring for recurrent Lyme disease at the end of the treatment.

    Case presentation of a patient with Lyme disease

    Dr. Smith presented one of her patients with Lyme disease in detail. She was a 45-year old executive. She suffered from extreme fatigue. It took quite a few tests to find out that her antibody titers against Lyme disease were very high.

    Here is her long list of symptoms: hair loss, four urinary tract infections in quick succession, brain fog, extreme fatigue, systemic pain, musculoskeletal pain, anxiety and depression, eczema, psoriasis, itching, stomach ache, trouble eating, weight loss of 12 pounds, flu, strep presented like meningitis.

    Comprehensive treatment of patient with Lyme disease

    Dr. Pamela Smith instituted a comprehensive treatment protocol. It turned out that she had developed gastritis, which was the reason for her weight loss. This needed conventional treatment. After the treatment with antibiotics, her energy picked up, and her appetite came back. She also engaged in yoga and other self-awareness programs. She deliberately slowed down her lifestyle activities. Her symptoms were mostly gone or significantly diminished. She was able to function. She experienced energy, joy, and could focus again. The only symptoms left were some mild pain, some bladder problems, some limitations with her diet and mild brain fog.

    Husband had Lyme disease

    Part of the work-up was to test her husband for Lyme disease. He tested positive. He was also treated although he was entirely asymptomatic. When his treatment was finished, the doctor tested him for a specific antibody and this came back as negative. This meant that he now was free of Borrelia burgdorferi and would no longer be able to infect her. The doctor thought that it was most likely through sex that she had contracted Lyme disease. The problem is that some people are completely asymptomatic, but nevertheless they can be carriers of Lyme disease.

    Lyme Disease The Great Imitator

    Lyme Disease The Great Imitator

    Conclusion

    Lyme disease, the great imitator, has become a more common disease in the US and around the world. Years back Lyme disease was often overlooked. But lately physicians have diagnosed Lyme disease earlier as diagnostic tests have improved. With earlier treatment a lot of suffering of the patient can be prevented. But in many cases symptoms are confusing as Lyme disease involves several organ systems. This makes the diagnosis more difficult. By diagnosing Lyme disease earlier, treatment can start at an earlier stage, and the patient will soon return to a state of wellness.