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At a recent conference of the International AIDS Society in Toronto the full spectrum of the disease was covered: science, community, activism, and people with AIDS.
News Canada data released before the conference suggests that HIV infection remains a serious problem. There were somewhere between 2,300 and 4,500 new cases of HIV in Canada. The numbers are up from the estimated 2,100-4,000 cases that came up in 2002.
There is one statistic that can be a source of hope: the number of deaths from the infection has shown a steep decline in the mid-90's. This effect is largely due to the discovery and application of three-drug antiretroviral therapy. The widespread use of this therapy has also reduced the viral load, and as a result infectiousness may be reduced.
UBC epidemiologist Dr. Evan Wood sees the encouraging development, but he emphatically spoke of the horrendous effect of AIDS. He stated, " HIV remains the biggest threat to humanity globally." He feels that the threat of terrorism pales in comparison to the carnage HIV results in every day. In this light it is short sighted and non-supportive of Canada's PM, not to appear at this conference, as he had other commitments.
This year also marks the 25th anniversary of AIDS' discovery, but it is known that the disease was ravaging Africa at least 25 years before it first appeared in the West.
The diagnosis of HIV infection does no longer sound like a death sentence. Things have been improving, but not fast enough, says Dr. Wood. Also one of the speakers, Bill Gates, spoke against naïve insistence on abstinence as a primary weapon in the battle against AIDS. Dr. Wood shared this sentiment. He stated that while the whole idea is well intended, sexuality is part of normal human behavior, and everybody knows that abstinence cannot exist forever.

National Review of Medicine, August 30,2006, page 14

Food Choices Can Boost Good Cholesterol

Dr. Andrew Pipe, a cardiologist at the University of Ottawa Heart Institute, sees a lot of people with cardiovascular problems. He also has found that telling patients to "reduce their cholesterol and get the triglycerides down" is not very helpful. Dr. Pipe is aware that we are living in a world where people are constantly tempted by junk food, and it is not surprising that obesity is one of the consequences.
It sounds daunting to a person with a lifetime of poor food habits and poor lifestyle choices to make changes. He believes that simplifying advice for healthy living can be brought down to 5 F's for healthy living:

-Fruit and vegetables, 3-4 each day
-Fish, 3-4 per week
-Fibre, 5 per day
-Fat, 3-6 per day. Monounsaturated fats are best
-Fast food: avoid it!

To this list Dr. Pipe added two more Fs:
- "Fysical" activity, 30-40 minutes per day. This may be a misspell, but it is the best way to increase your good cholesterol (HDL)
-Fun, unlimited. Your food choices and exercise need to be enjoyable and appealing or the plan does not work in the long run.

National Review of Medicine, August 30,2006, page 10

Cartoons Help Kids Deal With Pain

Shots in early childhood are often approached with a sense of trepidation by parents. It means almost without fail, that there is crying and resistance. All the well meaning comments, that it is "only like a little mosquito bite" to get a shot at the clinic are of not much use.
Italian researchers were able to confirm that children feel significantly less pain from blood draws when their mother was at their side. But this study from Siena, Italy also suggests that there are additional ways to distract children from pain. Sixty-nine children aged 7-12 were observed, and the study suggests that TV cartoons have an even greater power to distract youngsters from pain. Researchers took note that children whose attention was focused on a cartoon reported only one-third of the pain reported by controls of those who did not watch a cartoon.
The practical application could be useful in labs or clinics, where children are receiving injections or may experience pain and discomfort. A funny cartoon may take some of the sting out of the dreaded shots!
The study originally appeared in the August 17 online edition of Archives of Diseases in Childhood.

National Review of Medicine, August 30,2006, page 11

Prostate cancer affects a significant percentage of male patients in the higher age groups. Early diagnosis and treatment has shown good success rates. Early surgery in the form of a radical prostatectomy has given patients virtually a new lease on life. Radiotherapy as an alternative form of treatment has been an option for those who could not undergo surgery. Once the treatment is completed there is reason for optimism, if the tumor could be removed in total.

Dr. Sara Strom, PhD and research colleagues from the M.D. Anderson Cancer Center in Houston, Texas analyzed findings of 873 patients over the course of 14 years with localized prostate cancer who had received external beam radiotherapy as their sole treatment. The objective was to determine, whether all patients were doing well, or whether some could be more at risk. It turned out that those with normal body weight fared best. 27% of them experienced a recurrence of the disease. Those who were overweight had recurrence rates that jumped to 55%. Those who were obese were most severely affected with recurrence rates of 99%. The researchers believe that there is a difference of tumor behavior between patients with normal body weight and those who are overweight or obese.
Future studies will be needed to evaluate the relationship of obesity with dietary factors, genetic modifiers of steroid androgen metabolism, insulin and insulin like growth factors. This will clarify the underlying mechanism of action in the development of prostate cancer.

The Medical Post, August 22, 2006, page 41

Suppression Of Estrogen Affects Cognitive Function

Female patients with gynecological problems such as fibroids and endometriosis can be treated with leuprolide acetate depot (LAD) or Lupron. LAD suppresses ovarian function and decreases estrogen to the levels of postmenopause. In menopause estrogen levels show a natural drop. In this group the estrogen levels were chemically suppressed. The patients ranged in the ages 25 to 40 years of age-all of them well before the age of menopause. The researchers were able to observe the effects of estrogen on cognitive function without the brain changes associated with normal aging.
Dr. Barbara Sherwin, PhD, professor for psychology and obstetrics at Mc Gill University in Montreal stated that previous research has shown a connection between decreased estrogen and the deterioration of verbal memory. Taking estrogen during menopause can prevent this deterioration. The current study also showed a significant decrease in working memory and scores regarding mood in the women who are taking LAD.
Dr. Sherwin suggested also that some research points to a window of opportunity around the time of menopause where estrogen will protect. But beyond that time, such as at the age of 65 or older, estrogen treatment does not provide these benefits. As shown in the Women's Health Initiative study it may be detrimental.

The Medical Post, August, 22, 2006, page 45

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