Jan
04
2015

Lifestyle Has Profound Changes On Our System

Dr. David Katz delivered a keynote address where he said that lifestyle has profound changes on our system. This took place at the 22nd Annual World Congress on Anti-Aging Medicine in Las Vegas Dec. 10-14, 2014. His talk was entitled “Integrative Medicine: A Bridge Over Healthcare’s Troubled Waters”.

He started the 1 hour talk with showing a slide of six blind men and the elephant. The conclusion was that each of the blind men saw only one aspect of the elephant, but no one saw the true elephant. With healthcare it is a bit like that.

Causes of death

Dr. McGinnis et al. in 1993 published the “Actual causes of death in the United States”.

Ten factors were responsible for chronic disease, but the first three things on McGinnis list were the most important ones: tobacco use, diet and lack of exercise.

Mokdad in 2004 noted that the revised list of “Actual causes of death in the United States”: tobacco was no longer number one.

Effect of healthy lifestyle

Ford et al. in 2009 stated: “Healthy living is the best revenge…Nutrition-Potsdam study

Although there is no magic pill for reducing disease, lifestyle is exactly “the magic pill” that reduces mortality by almost 80%.

Fastforward to 2014: Akkeson et al. came to the same conclusion when examining what would be able to prevent heart attacks. They stated that LIFESTYLE is what matters.

We live in the “epigenetic age: dinner is destiny!” With this Dr. Katz meant to say that our genes get switched on and off depending on what we put into our mouths. This determines whether we live shorter or longer lives.

He went on to say: “Feet (exercise), forks (diet), fingers (cigarettes) are what matters.” Oncogenes can get turned off in prostate cancer with the help of exercise, the right food intake and quitting to smoke.

Food addiction and obesity

Dr. Katz mentioned the book by Michael Moss “Salt, sugar, fat”, which made it to the cover story of Time Magazine in 2013. In it is described how the food industry employs PhD’s to include agents in processed foods to ensure that consumers get addicted to the food products. Food addiction leads to obesity; the CDC statistics show that it is effective! We have put up with this for far too long. There are differences of obesity rates between countries, here Canadian and US statistics shown.

Dr. Katz asked the audience to raise up their hands, if they had a person close to them die of cancer, a heart attack or a stroke. Almost all of the more than 500 participants in the Hall raised their hands.

Lifestyle Has Profound Changes On Our System

Lifestyle Has Profound Changes On Our System

Children education programs

So what is the ONE thing that can fix everything? He answered this rhetoric question by saying that there is no one thing that fixes everything. But we can start at a young age by educating our children. Dr. Katz has started a program for school kids called “ABC for fitness for kids” to prevent obesity. The program teaches children healthful food choices. Dr. Katz commented that a website, NuVal uses a nutritional value rating system to monitor food quality and manufacturers have improved the content of their products because the composition of their products were displayed on that website. We need to be vigilant and read labels.

Change one thing at a time

But we can only change one thing at a time, like we walk one step at a time on a spiral staircase to get to the next floor. We ask ourselves about our lifestyle: what is the first thing to fix? We fix this point (like exercise more), then we fix the second (adopt a Mediterranean diet), the third (take specific vitamins and supplements) and so on; in other words we approach one thing at a time. Integrative medicine, the fusion of conventional and non-conventional medicine, can help to solve problems one step at a time.

Effect of CoQ10

Despite a bias in the North American medical literature saying that CoQ10 was “useless”, the European Heart Journal reported in 2013 that CoQ10 decreases all-cause-mortality in patients with heart disease. Here is a link to a more recent article (Dec. 2014) regarding a two year trial with congestive heart failure patients taking only 100 mg of CoQ-10 three times daily that found that all-cause-mortality was reduced significantly.

Blue zones

There is a new wave going around the United States: It is the idea to copy the lifestyle of the blue zones around the world. Blue zones are areas in the world where the life expectancy is 100 years or more. This link leads you to a information about blue zones that is worth watching.

It explains how Blue Zones are being established all around America. Dr. Katz explained that lifestyle is the medicine and the environment is the spoon. In Blue Zones the environment is such that people who live long, healthy lives influence you positively. They spoon it to you non-verbally by their example. Organic vegetables in stores are cheaper in Blue Zones, so it is easier to eat more of them; people socialize more with each other, they exercise more and dance. This is what people do who live longer than 100 years. In other words, you change the culture, you change your lifestyle, you exercise more, you stop smoking, you eat healthy and you live longer.

You must decide on which pathway to go

Dr. Katz ended his lecture with the image of you walking along and coming to a fork. To go further you must decide to go on the pathway to your right or on the pathway to the left. You turn on the right pathway by deciding to adopt the principles of the Blue Zones; you make the decision to want to turn older than 100 years and keep your vitality until it is time for you to pass on. In the meantime you enjoy every day, you are not disabled and your mind and body stay healthy. The other pathway was the one that the majority of the industrialized Western nations has taken in the last few decades. Which path will it be that you decide to take?

Conclusion

At the conference Dr Katz and a number of other speakers pointed out how powerful lifestyle is for our body functions. Other speakers stressed the importance of telomeres, the caps of the chromosomes, which comprise the end of the double stranded DNA. With every cell division our telomeres shorten. Stem cells also have telomeres, but they are on average longer than the somatic dells. It probably is like this to be able for stem cells to replace the aging somatic cells.

There is a new logic of a healthy lifestyle is. It says that a healthy lifestyle causes healthy telomeres of somatic cells and of stem cells. This causes health until a ripe old age. I will be blogging about some of the other key talks of the conference in the near future to clarify this point further.

Feb
12
2013

Stem Cell Treatments That Are Currently Available

In the first place I am discussing stem cell treatments that are currently available. By the same token stem cells got a bad reputation in the beginning of stem cell research. As a matter of fact, researchers at that time thought that embryonic stem cells were necessary to treat degenerative conditions. Be that s it may, immediately this raised an ethical flag, as physicians would harvest embryonic stem cells from a dying fetus. Similarly, this created a lot of unnecessary division among the public and scientists. To put it another way, it turns out that for most treatments there are enough stem cells in the body. As I will explain below,  this was not general knowledge in the beginning.

Dolly, the sheep

With this in mind, the next bad rep came from Dolly, the sheep that was born on July 5, 1996. She only lived for 6 years, because the telomeres were short like that of an old animal and she died of a progressive lung disease. It is important to realize that researchers used a complicated stem cell technique to create Dolly. The method went under the name of “somatic cell nuclear transfer”. Three animals were necessary to achieve this. Researchers used an unfertilized egg from one animal from which they extracted the nucleus. The second animal donated a cell nucleus of a breast gland cell. A third animal served as a surrogate mother. After some cell divisions the researchers introduced the blastocyst into the uterus of the surrogate mother who carried baby Dolly until birth.

Mesenchymal stem cells and bone marrow stem cells

Fast forward to 2013. We now know that stem cells are fragile cells that do not like too much manipulation. Stem cells have long telomeres so they are younger than the typical cells of the body. Stem cells are present in the bone marrow, in fatty tissue and many other organs. In the last few years research has shown that this has already translated into practical applications. Originally researchers thought that stem cells were cells that could develop into any variety of body cell. Physicians at that time thought that stem cells would derive from bone marrow or from fetal tissue. Scientists called these cells “pluripotent cells”.

Induced pluripotent stem cells and mesenchymal stem cells

In the last years researchers could show that it was possible to turn off the SP100 gene could also prompt a body cell to become such a versatile, pluripotent stem cell. They are called “induced pluripotent stem cells” to distinguish them from embryonic stem cells, which have been highly contentious with religious groups. In recent years matters have been simplified with the observation that mesenchymal stem cells are distributed freely throughout the body and can be harvested fairly easily from fatty tissue by liposuction. Physicians prefer this latter technique, as it does not involve any manipulation of the stem cells themselves.

 

Stem Cell Treatments That Are Currently Available

Non-Surgical Space Lift, Before and After

Here are a few examples of what is happening now and what developments are probable in the future:

Minimal invasive face-lift, called “space lift”

Mesenchymal stem cells are freely available in fatty tissue. Plastic surgeons in the US and elsewhere are using mesenchymal stem cells for a minimal invasive plastic surgery. In this “space lift” procedure the surgeon removes fat by liposuction. A cell separator separates the fat graft into a fat cell fraction and into a mesenchymal stem cell rich fraction. The physician injects fat cells and stem cell rich fraction together into various areas of the face where subcutaneous tissue is needed.

Facial rejuvenation

The mesenchymal stem cells enable the fat cells that were transplanted to latch on to the small vessels in the transplanted area so that they survive permanently. The result is a more youthful appearance of the face (see image). This is the secret of film stars in Hollywood. Nowadays the plastic surgeons in Beverly Hills do not do the conventional facelifts so much as they lead to artificially looking faces. They rather do the minimal invasion space lift for the natural look.

Knee problems, hip problems and lower back problems

Why wait with degenerative diseases of the knees, hip or of the lower back until there is permanent scarring and disabilities? Physicians can inject the mesenchymal stem cell rich fraction (without the fat cells this time) into diseased joints. This is a useful tool for degenerative changes in knee joints, hips and facet joints along the spine. The result is that the transferred mesenchymal stem cells recreate cartilage and the patient becomes pain free and regains mobility! But as with other diseases it is important to intervene early enough before permanent damage has set in.

Organ failures

Another exciting development is intravenous injection or injection via an arterial catheter into failing organs. Heart failure is an end-stage heart disease, where conventional medicine has nothing to offer other than symptomatic supportive medication. In contrast, physicians can inject mesenchymal stem cells into the blood. The pluripotent stem cells will find the weak areas in the heart muscle.  It is there that they transform into heart cells and give the existing heart cells a boost.

The result is that the heart pumps more forcibly and the symptoms of heart failure disappear.

Parkinson’s disease and liver failure

Similarly, there are trials that show that Parkinson’s disease can be positively influenced with injections of the mesenchymal stem cell rich fraction.

Treatment of patients with liver failure using mesenchymal stem cells is being investigated, but is still in its infancy.

Chronic kidney failure

With regard to mesenchymal stem cell treatment of chronic kidney failure early human experiments on 30 patients showed very encouraging results.

Although this field is very promising, more caution is in order with regard to laboratory-manufactured stem cells. Researchers need to do more trials to show that they are ready for use in regenerative medicine. They have to show similar or even better successes as the present results achieved with mesenchymal stem cells. Physicians harvested mesenchymal stem cells directly and did not change them as described above.

More information on:

1. stem cells for stroke victims: http://nethealthbook.com/news/stem-cells-help-stroke-victims/

2. stem cells for knee osteoarthritis.

Feb
01
2005

Stress Incontinence Stopped with Stem Cells

About 30% of people over 60 suffer from urinary stress incontinence, a frustrating and embarrassing condition. It tends to occur, when the sphincter muscles that open and close the urethra become weak and diminished or when the urethra becomes narrowed. Urine leakage will occur, if a person coughs, sneezes, lifts heavy objects, exercises or laughs. For the patient it is no laughing matter, and neither surgery nor incontinence pads have proven to be the solution to the problem. Medication has been available, however with any medication, side effects remain a reality.

According to new research from The University of Innsbruck, Austria, a revolutionary treatment for stress incontinence has been developed. Dr. Ferdinand Frauscher presented findings at a meeting of the Radiological Society of North America in Chicago, which look very promising. The treatment involves the removal of stem cells from a patient’s arm, which are cultured for six weeks and then injected into the sphincter muscle and the wall of the urethra. To achieve this stem cell therapy a special three-dimensional transurethral ultrasound had to be developed, so researchers could see exactly where the new cells had to be placed. The therapy is minimally invasive and can be done under local anesthesia. The initial study involved 20 women with minor to severe stress incontinence. Many reported an improvement after only one day, and 18 remained continent one year after injection. Ultrasound findings showed a significant increase in the thickness of the urethra and the sphincter muscle.

Stress Incontinence Stopped with Stem Cells

Stress Incontinence Stopped with Stem Cells

The muscle also showed an improvement in contractibility. The cost of the procedure was comparable to other popular incontinence treatments, such as collagen injections and the long-term purchase of adult diapers.

At this point it is not known, when this treatment will become widely available in North America.

References: The Medical Post, January 4,2005, page 18

Last edited December 7, 2012