Jul
01
2006

Better Blood Pressure Control With New Drug

By | Heart Disease, High Blood Pressure, Prevention, Stroke

Numerous medications for blood pressure control are in circulation. Treatment of high blood pressure patients is crucial in the prevention of strokes, but despite the multitude of drugs that are on the market, the treatment has its challenges. Some of the drugs have side effects, like an irritating cough, and a suitable medication has to be tried out first. Even, when all is well and there are no unpleasant side effects, many patients have a problem with compliance. Pills that have to be taken several times per day are forgotten. As a result, the patient will have poor blood pressure control.
Blood pressures must be controlled on an ongoing basis. Ideally there are no big fluctuations, whether it is day or night. For this purpose, a medication has to stay in the system of the patient long enough. This time stretch is called the half-life of a drug.
The first drug in a new class of agents for the treatment of high blood pressure does exactly that: it has a long half-life, so blood pressure control is smooth and continuous, day or night. The oral direct renin inhibitor aliskiren has the potential to protect the heart and other organs with a once-daily dosage of 150 mg or 300 mg. The drug is being developed by Novartis, and clinical trials are on their way.
The medication in combination with a diuretic provides significant additional blood pressure reduction. The agent at work is a renin inhibitor (also known medically as “renin antagonist” as it blocks the effects of renin). In the past, renin inhibitors for treatment of hypertension (high blood pressure) could only be used as intravenous solution and this was only effective for a short time.

Better Blood Pressure Control With New Drug

Better Blood Pressure Control With New Drug

The new development is a breakthrough, as the medication is taken by mouth and it continues to work even when the drug is gone from the blood stream. It is ideal for daily dosing, and there is no apparent buildup in the body.

More information about hypertension (high blood pressure): http://nethealthbook.com/cardiovascular-disease/high-blood-pressure-hypertension/

Reference: The Medical Post, June 13, 2006, page 38

Comment on Nov. 13, 2012: Aliskiren  (brand name “Tekturna”) was approved by the FDA in March of 2007. However, as all drugs, it does have some side-effects like headaches, cough, angioedema, skin rash, elevated uric acid with gout etc. (see this Wikipedia link).

Last edited Nov. 1, 2014

Jul
01
2006

Exercise Can Reverse Risk Of Heart Disease

By | Fitness, Heart Disease, Prevention

A growing health concern is cardiovascular illness. As a rule the risk increases with unhealthy life style choices. The most common neglect is the lack of physical activity, and a couch-potato existence is a sure recipe for poor health. Often juvenile “couch potatoes” lay the groundwork for health problems in their middle age years.
Jennifer Robbins of Duke University in Durham, N.C. led a follow-up study on a group of participants. The objective was to examine, how much impact an exercise program would have on the overall condition of the participants. Fitness parameters included weight, waist circumference, visceral and subcutaneous fat, cholesterol levels and metabolic score.
In a control group 61 subjects were instructed not to change their dietary habits or exercise habits for 6 months. Researchers expected that the general health condition of these people would stay the same. What was observed, however, was a deterioration of all the fitness parameters. The sedentary group actually got worse! At the end of the study, all the 61 were offered to participate in one of the exercise programs offered to the other groups. 53 participants decided to take part, and they were enrolled in a low- intensity, medium-intensity and high- intensity exercise program. The two lower groups managed to reverse the detrimental effects of inactivity on cardio-vascular risk in a half-year exercise program. The researchers noted also that the ones who had deteriorated the most during the sedentary period achieved the most improvement from the exercise program.

Exercise Can Reverse Risk Of Heart Disease

Exercise Can Reverse Risk Of Heart Disease

Exercise Physiologist Jennifer Robbins and her team concluded, that the study result gives encouragement to those who don’t exercise and feel bad about it, as they will reap the most benefits. The results also give doctors more incentive to make physical exercise part of a prescription regimen. With a word of recommendation from the physician patients are more likely to enrol in an exercise program and stick with it.

More info about:

Heart disease: http://nethealthbook.com/cardiovascular-disease/heart-disease/

Fitness and exercise: http://nethealthbook.com/health-nutrition-and-fitness/fitness/ 

Reference: The Medical Post, June 20, 2006, page 47

Last edited Nov. 1, 2014

Jun
01
2006

Probiotics Help Gut Against Stress

By | Cancer, Gastrointestinal Disease, Health, Heart Disease, High Blood Pressure, Nutrition

In times of stress our bodies react: the heart will beat faster, palms will feel sweaty, and a difficult situation may manifest itself in other reactions of the body. In every day’s terms we speak about something “being a pain in the neck”, or the fear of an exam showing up as “butterflies in the stomach”.
Dr. Mary Perdue of the Intestinal Diseases Research Program at Mc Master University in Hamilton, Ontario went a step further. The fact that mental stress can bring physiologic changes in the lining of the intestine has been known for some time. As a result the epithelium (the lining) is more vulnerable to the attack of pathogenic bacteria. The researchers put a solution of lactobacillus to the test, to see whether these gut-friendly bacilli could offer some help. Stressed rats that received the treatment with lactobacillus showed a remarkable degree of protection. The stressed and treated animals were almost as resistant to intestinal pathogens as animals that had not been stressed at all. Contrary to that the non-stressed animals did not show much evidence of bacterial adhesion or penetration: they were more resistant to the attack of bacteria to their guts.
Dr. Perdue explains that it may be difficult to extrapolate from the rat model to the human model. Yet it is clear that humans who are stressed can develop intestinal dysfunction over time, or gastrointestinal symptoms can be exacerbated by stress.
In the meantime probiotics are recommended by many doctors and nutritionists to help restore the gut’s natural flora. New guidelines from Yale Medical School recommend them for diarrhea in children and adults and in diarrhea, which comes as a result of treatment with antibiotics.

Probiotics Help Gut Against Stress

Probiotics Help Gut Against Stress

More research is needed, but existing data suggest that probiotics can help manage lactose intolerance, prevent infections, and reduce inflammation. It can lower cholesterol and lower blood pressure and may help with prevention of colon cancer.

More information on:

1. Stress management: http://nethealthbook.com/health-nutrition-and-fitness/fitness/stress-management-relaxation-techniques/

2. Probiotics: https://www.askdrray.com/probiotics-important-for-your-health/

Reference: National Review of Medicine, May 15, 2006, page 8

Last edited Oct. 31, 2014

May
01
2006

Blood Clots Related To Air Travel

By | Health, Heart Disease

Extended air travel and sitting in the narrow seat of a plane has been blamed for the risk of deep vein thromboses (DVT). The formation of a blood clot in the leg veins is not only an inconvenience that causes severe leg swelling. It cannot be ignored, as untreated it may progress to an embolus, a clot that travels in the blood stream to lung or brain. Pulmonary embolism can kill! The affected patient needs treatment with blood thinners to dissolve the clot.
Pamphlets in planes encourage the traveler to move legs, feet and toes to counteract a stagnant blood flow in the leg veins. It remains a good practice for any traveler to get up and move about on lengthy flights. Some individuals are more susceptible than others to develop blood clots. It has been known for a while that the use of oral contraceptives is associated with a risk of clotting.
Dutch researchers under the leadership of Dr. Frits Rosendaal of Leiden Medical Center in the Netherlands recently published some of their findings.

They examined, whether sitting for extended periods in narrow spaces would be the main risk for the formation of DVT. The volunteers were 15 individuals with no known risk factors for DVT. The group also had 11 women, who were carrying the factor V gene (a known risk for blood clotting), 15 women who were taking oral contraceptives, and another group of 15 women who had the factor V Leiden and were taking oral contraceptives. The entire group was taken on an 8-hour flight aboard a chartered 757 jet. Blood samples were taken before, during and after the flight. Several weeks later the same people sat through a movie marathon at a cinema, where the seats had the same legroom as the plane. Blood work was done as with the previous setting on the plane. No one was allowed to drink alcohol, take aspirin or wear compression stockings during the experiments. The test persons were asked to remain seated as much as possible, both during the flight and at the movies.
Finally the group was monitored for 8 hours while they went about their normal day-to-day routines.
The results showed that 17% of the entire group had early signs of possible clotting in their blood after the flight. After the movie marathon only 3% showed the same signs. The rates dropped to 1% during normal everyday routines. As predictable, the group with the factor V gene who were also taking oral contraceptives was at the highest risk.

Blood Clots Related To Air Travel

Blood Clots Related To Air Travel

As a result of these findings, the researchers believe, that sitting is not the only risk for the development of blood clots. The combination of low cabin pressure and low oxygen levels in jet travel may increase the risk for DVT in susceptible individuals.

More on blood clots: http://nethealthbook.com/lung-disease/pulmonary-emboli/

Reference: The Medical Post, March 28,2006, page 50

Last edited Oct. 31, 2014

Sep
01
2005

Dark Chocolate For Lower Blood Pressure

By | Heart Disease, High Blood Pressure, Nutrition

Chocolate, as long as it is consumed in moderation, can be good for you. The beneficial ingredients are the bioflavonoids, the same substances that are also found in fruit and vegetables.
Dr. Jeffrey Blumberg, PhD, at Tufts University in Boston reported about a study, where 20 adults with hypertension (high blood pressure) were asked to eat white chocolate or dark chocolate for 15 days. Blood pressure was reduced by an average of 12/9 mmHg with the dark chocolate. White chocolate had no effect, as blood pressures stayed the same. Dark chocolate also caused a dip in the LDL cholesterol and lowered insulin resistance.
The reason for the benefits lies in the bioflavonoids content: dark chocolate is rich in bioflavonoids, whereas milk chocolate contains little, and white chocolate the least of the three.
For all chocoholics this is not a ticket for a box of Belgian dark chocolates or an assortment of candy bars in one sitting.

Dark Chocolate For Lower Blood Pressure

Dark Chocolate For Lower Blood Pressure

Moderation is still the key, and you may consider consuming cocoa, perhaps as a Mexican chocolate drink without the fat and without the sugar.

References: The Medical Post, August 9, 2005, page 19

Last edited December 7, 2012

Aug
01
2005

Tight Blood Sugar Control In Diabetics Cuts Heart Disease

By | Diabetes, Heart Disease

Successful treatment of type 1 diabetes in the past usually meant compliance in taking insulin shots and paying attention to a diabetic diet. Since the arrival of specific lab tests like the HbA1c levels, patient education has become more sophisticated: it is not enough to just be on shots, eat sensibly and otherwise hope for the best. As a result, it is a must for patients to monitor their glucose levels closely.
Research that was presented at the American Diabetes Association during the 65th annual scientific session spelled out the benefits very clearly: strict control of glucose levels helps patients with type 1 diabetes to decrease the risk of stroke and cardiovascular disease by 57%!

It has been known that tight glucose control helped to reduce diabetic nephropathy (kidney disease) and diabetic retinopathy (eye disease) in diabetics, but this is the first time that controlling glucose levels has been associated with cardiovascular disease, reports the main investigator, Dr.David Nathan from, director of the diabetes center at Massachusetts General Hospital in Boston. He also reported that every 1% reduction in HbA1c (glycosated hemoglobin) correlated with a 20% reduction in cardiovascular risk for the diabetes type 1 patient.

These findings are significant, as the risk reduction is larger than seen in any other trials, like administering medication (statins) or placing stents.

Tight Blood Sugar Control In Diabetics Cuts Heart Disease

Tight Blood Sugar Control In Diabetics Cuts Heart Disease

A similar risk reduction may also occur in patients with type 2 diabetes, but at this point no specific research on this group is available. In the meantime it is of great importance to any patient with type 1 diabetes.

More information about:

1. Diabetes treatment: http://nethealthbook.com/hormones/diabetes/type-2-diabetes/treatment-type-2-diabetes/

2. Heart attacks: http://nethealthbook.com/cardiovascular-disease/heart-disease/heart-attack-myocardial-infarction-or-mi/

Reference: The Medical Post, July 5,2005,page1, 58.

Last edited October 29, 2014

Jul
01
2005

Tooth Implants For Better Health

By | Dentistry, Health, Heart Disease

Missing teeth are often just ignored -why bother? There are still all the others around to assume the necessary functions! The truth is different: missing teeth can affect us in the way we eat, speak, rest, and appear. They can influence our behavior and overall functioning. A missing tooth can also compromise the dental health of its neighbor.
In the past the only options for missing teeth was either dental bridges or dentures. Bridges and dentures still have their place now, but the benefits for dental implants are significant.
-They help to preserve remaining natural bone structure.
-They reduce the need to cut out adjacent teeth for a bridge.
-They eliminate the need for removable partials or dentures and the sores that may go along with them.
-The roof of the mouth does not need to be covered by removable partials or complete dentures.
-They look, feel and work just like natural teeth.
-They support face shape, smile and provide confidence when eating and speaking.
-A few exceptions apply: people who smoke and people who have diabetes, particularly when uncontrolled and severe, have much less success with implants, as healing is impaired. However, you may consider quitting smoking and diabetes may be able to be controlled better with the help of a specialist. Other patients who have pacemakers, artificial heart valve replacements or other implanted devices may have to stay away from implants and they may have to stick to more conventional methods such as bridges and dentures.
The dentist will do a thorough examination to decide, whether you are a candidate for dental implants. Each tooth will be examined and a medical and dental history will be taken. Special x-rays (panoramic and tomograms) are needed to determine whether there is enough bone available. This helps to decide whether the implants can be placed directly, or whether grafting more bone will be necessary. This step is very important. It also helps the dentist to identify important structures, like nerves, sinuses and adjacent tooth roots. You will discuss all the treatment options with your dentist, which also helps to clarify expectations about the final results. This comprehensive treatment plan can be compared to building the foundation of a house. The foundation has to be solid, so the final structure holds up. A properly done dental implant should be a one-time job.

Tooth Implants For Better Health

Tooth Implants For Better Health

The procedure itself is done in the dental office or in a surgical suite under a local anesthetic, and over-the-counter pain medication may be needed after the surgery. The time it takes to heal can be variable. It may take up to six months, but it is important that healthy bone develop around your implant, which is the strong bond that is needed to hold the implant in place. Once the healing is complete, your dentist takes a final impression, which is needed by the dental laboratory to create the permanent teeth.
Once the permanent teeth are placed you will receive care and a dental hygienist will instruct you in dental hygiene. Special plastic cleaning instruments are used to avoid scratching the titanium surface of the implant. Just as with natural teeth, implant-retained teeth need to be cleaned daily and need to be regularly checked by a dentist.
Looking at the overall picture it is clear, that the dental health and function of our teeth closely relates to every facet of our overall health, from speech to the function of our digestive tract and proper nutritional status, which affects cardiovascular health as well. A tooth implant involves a lot of detail work and effort, but its benefits are far reaching.

Reference: Family Health, Vol. 21, No.2, Summer 2005 (June), page 9-13; published by The College of Family Physicians of Canada

Other links re dental implants:

Association of Prosthodontists of Canada

American College of Prosthodontists

Last edited December 7, 2012

May
01
2005

Inflammation Connected To Sudden Heart Death

By | Diabetes, Heart Disease, Prevention

It is a well-known fact that certain diseases go together, for instance diabetes and heart disease. Every effort has to be made for this reason to control a disease in order to minimize the risk for other associated illnesses.
New research from rheumatologist Dr. Sherin Gabriel at the Mayo Clinic points to another health condition. Patients affected by rheumatoid arthritis have a higher risk of early death than others, and these deaths are mostly due to cardiovascular disease. The relationship between these two diseases is complex, reports Dr. Gabriel, and the common denominator between heart disease and rheumatoid arthritis seems to be systemic inflammation.

Research from the Mayo Clinic in Rochester, Minnesota, has been published in March, and it was found that inflammation documented by laboratory tests such as an erythrocyte sedimentation rate of over 60mm per hour increased the risk for heart disease by a factor of two. Rheumatoid arthritis vasculitis increased the risk to 2.4, and RA lung disease showed a risk increase of 2.3. Traditional risk factors for heart disease like smoking, alcohol, obesity and diabetes were accounted for, yet the more dramatic risk factor in the population with RA (rheumatoid arthritis) was the aspect of inflammation. The results of this research are based on data from the Rochester Epidemiology Project, in which 603 persons with rheumatoid arthritis were followed over 15 years. In this time span 364 of these patients died, and heart disease was the primary cause of death in 176 of them. The subjects of this group were three times as likely as an age-matched population to have been hospitalized for a heart attack and had five times the risk of having an unrecognized heart attack. This group is also more vulnerable, because patients with rheumatoid arthritis suffer of joint pains, receive painkillers, and often chest pain can be masked by pain medication and go unrecognized.

Inflammation Connected To Sudden Heart Death

Inflammation Connected To Sudden Heart Death

Co-author Dr. Hilal Maradit points out that rheumatoid arthritis remains a multifactor problem, and one factor alone does not explain the entire story, but in the meantime the link of inflammation in RA to cardiovascular disease is an important step closer to early recognition and successful control.

More info about:

Rheumatoid arthritis: http://nethealthbook.com/arthritis/rheumatoid-arthritis/

Gingivitis: http://nethealthbook.com/dentistry/gingivitis/

Heart attacks: http://nethealthbook.com/cardiovascular-disease/heart-disease/heart-attack-myocardial-infarction-or-mi/

Reference: National Review Of Medicine, April 15, 2005, page 3

Last edited October 28, 2014

May
01
2005

Burgers, Fries and High Healthcare Costs

By | Cancer, Health, Heart Disease, Nutrition, Obesity, Stroke

“Everything in moderation” and “A little bit cannot harm” are the deceptively soothing terms that can lull consumers into the belief, that fast foods cannot be so bad after all. A study, called the” Coronary Artery Risk Development in Young Adults” however gives us the facts, that paint a more realistic picture: the “little bit” actually has fairly serious consequences!
In this U.S. study a wide cross section of young adults were followed in four U.S centers: Birmingham, Ala., Chicago, Minneapolis and Oakland Calif. 3031 people in the age of 18 to 30 years were recruited in 1985 and followed until 2001.

Lifestyle habits, such as smoking, watching TV and intake of other foods were recorded, and insulin resistance was measured. In addition there were detailed studies of weight, height, waist size and other body measurements. Some interesting facts emerged: women ate fast foods less frequently than men. Fast food intake was associated with lower education, more TV watching, lower physical activity, high intake of trans fats and alcohol intake. In short: fast foods and other unhealthy lifestyle choices were correlated.

Dr. Mark Pereira, PhD of the University of Minnesota School of Public Health, who is one of the authors of the study, points out that it is extremely difficult to eat in a healthy way in a fast foods restaurant. The menus still include foods high in fat, sugar and calories and low in fiber and nutrients. Dr. Arne Astrup from the RVA University in Copenhagen found the same issues: besides the fact that serving sizes have increased two to five fold over the past fifty years, the energy density is twice as high in fast foods as compared to food in healthy diets. Dr. Astrup also points out in his publication, that humans have only a weak innate ability to recognize foods with high energy density and then down-regulate the amount eaten to meet and not exceed energy requirements.

Burgers, Fries and High Healthcare Costs

Burgers, Fries and High Healthcare Costs

If a person ate more than 2 fast food meals per week, which would be a modest increase of the control group that ate less than 1 fast food meal per week, the 2 meals per week group was about 5 kg heavier after 15 years, as opposed to 11 kg in the control group. The insulin resistance increased by an alarming 230 %. This finding is of significance, as insulin resistance (=metabolic syndrome) promotes the occurrence of cardiovascular disease and cancer, especially breast and colorectal cancers. The data are showing that even a modest increase has a unique effect in increasing the risks for these disease patterns, and the message is, that health care costs will only come down, if the root cause of disease is attacked at the societal and lifestyle level.

More information about the metabolic syndrome (insulin resistance): http://nethealthbook.com/hormones/metabolic-syndrome/

Reference: The Medical Post, March 8, 2005, page 20

Last edited October 28, 2014

Incoming search terms:

Feb
01
2005

Public Strategies Help Quit Smoking

By | Cancer, Heart Disease

Quitting to smoke has been a New Year’s resolution for many, and in view of the health care dollars spent for diseases related to smoking and the approximately 440,000 deaths in the United States per year alone, it should be a priority to implement comprehensive tobacco-control programs.
Smoking was more common among men (an average of 24.8 % nationally), whereas a national average of 20.3% of women lit up. There are also considerable differences between various states. In Kentucky 33.8% of men and 28.1% of women were smokers. Utah had the lowest prevalence with 14% men and 9.9% women. The national health objective is a goal for 2010 is to reduce the numbers to 12% smokers, which underscores the need for increased efforts to reduce tobacco use. Strategies include a clean air act to ensure clean indoor air laws, media campaigns, telephone support quit lines, insurance coverage for cessation counseling and pharmaceuticals are effective, but there are substantial variations across the states. In addition there are significant differences in the cost of cigarettes. It comes as no surprise, that Kentucky, which has the lowest price at $3.10 per pack, also has the highest number of smokers. Telephone support lines are available in the majority of states, but in 2002 only 2 states offered Medicaid coverage for medication treatment or counseling, and only six states (California, Conneticut, Delaware, Maine, Massachusetts, and New York) have comprehensive statewide smoking bans in effect on indoor workplaces and public places.

Public Strategies Help Quit Smoking

Public Strategies Help Quit Smoking

Too few states have public smoking bans in effect. Only four states (Arkansas, Delaware, Maine, and Mississippi) were investing at least the minimum per capita amount that the CDC recommends for tobacco-control. There is obviously the need to expand efforts and resources, to achieve the goal to reduce the smoking habit to 12% in the population by 2010.

Reference: Journal Of The American Medical Society, December 22/29,2004,Vol.292, No.24