Feb
14
2015

Laser Therapy Going Beyond Skin Deep

There was an interesting workshop alongside of the A4M conference mid December 2014 organized by Jonathan Schwartz who gave an overview of the use of low-dose laser therapy for various clinical applications. It involved the use of the Dr. Michael Weber low-dose laser machine, which has a lot of versatility.

  1. First there are 5 laser light frequencies in the rainbow colors (infrared, red, yellow, green, blue) and the colors have very special characteristics as will be explained further below.
  2. There are a multitude of applicators like skin acupressure point applicators, a shower for hair loss applications, a head adapter, which looks like a crown. With this device red light will penetrate into the brain through the skull bone. There is also a mouth shower and various lengths needle applicators that can be used to access the body intravenously or interstitially (direct tissue approach). At the center of the equipment is the Weberneedle Compactlaser, which can be attached to the various applicators.

Laser characteristics

The blue laser penetrates about 1 cm (0.39 inch) under the skin, a green laser penetrates only 0.5 cm (0.19 inch); like the blue laser the yellow laser penetrates through the skin with a depth of 1 cm (0.39 inch). The red laser has a penetration depth of 2-3 cm (a bit more or less than 1 inch) and the infrared laser penetrates 5-7 cm (2 to 2 1/2 inches).

In addition the various lasers have different inherent qualities: The red laser is good for tissue regeneration, which lends itself for chronic pain. Green and blue lasers have anti-inflammatory effects, which helps in acute pain. The yellow laser can be used for detoxification, has antidepressant qualities and photosensitizes hypericin, a substance derived from St. John’s wort, which is known to have antidepressant qualities. The various types of laser mentioned can be used interstitially, intravenously and just on the skin surface over acupuncture points. Dr. Weber explained that detailed research has revealed that the low-dose energy beam sends out energy that is taken up by the surrounding tissues and cells. The mitochondria of the cells get activated to produce more ATP, which the cells use to heal themselves.

Meeting in Placentia

Forward to a meeting in Placentia, CA on Feb. 7, 2015 where Dr. Michael Weber and several other speakers gave presentations on the use of the Dr. Weber laser system. A number of local doctors who had an interest in learning more about the low-dose laser system were there as well. It was a daylong mini conference.

Three volunteers were used to demonstrate the use of the system. I was volunteering about a chronic left lower back pain that various chiropractors had problems adjusting in the past year. I have a strong family history of arthritis on my mother’s side and my maternal grandmother’s side as well. The health professionals thought that I likely have developed arthritis in the left sacro-iliac joint. Dr. Weber used the interstitial needle, which is 4 cm (1.57 inches) long. The skin was injected with a local anesthetic first, and then the needle was inserted, which I could hardly feel. Now he injected 5 cc of normal saline. This was used, so that the laser light would spreads more into the surrounding area. Dr. Weber explained that he was very close to the SI joint with the tip of the needle on the left. He attached a blue laser to it for 20 minutes and switched it to a green laser for another 20 minutes.

In the meantime the other two volunteers were treated.

One was a physician in the group who had a chronic planter’s fasciitis. He was treated with an intravenous laser application. First a special butterfly was inserted, through which a sterile laser probe could be threaded and then attached. He received a red laser.

The third volunteer had a chronic right knee problem from congenital Osgood Schlatter disease. In him Dr. Weber used an approach of intraarticular injection and he attached a blue laser for 20 minutes, followed by a yellow laser for another 20 minutes. A physician with a California license supervised all of these procedures.

I woke up the following day with no pain in my left lower back, but at the same time the lesser right lower back pain had also disappeared. I figure that due to the fact that my back mobility is back the untreated right side must have normalized as well. It is now 7 days following the procedure and I still have no back pain. Yesterday I saw my local chiropractor in Southern California and he confirmed that my back was much easier to adjust than the month before (Update April 12, 2015: my lower back is still pain free!).

Normally a case like mine would require 5 to 6 weekly treatments before the problem is resolved. Dr. Weber explained that more complicated problems like fibromyalgia would take 15 to 20 treatments in succession or more. The principal is always that you treat where the symptoms are; in the follow-up visit the healthcare practitioner treats the remaining symptoms until all of the symptoms have resolved.

The intriguing fact is that low-dose laser therapy seems to fit right into gap where conventional medicine has failed.

Clinical cases that respond to laser therapy

Dr. Weber has collected clinical cases that improve with laser treatments, such as diabetes, chronic liver diseases, chronic pain syndromes, rheumatoid arthritis, polyneuropathy, chronic inflammatory disease, cancer (with photodynamic therapy), fibromyalgia, high blood pressure, ringing in the ears (tinnitus), macular degeneration, multiple sclerosis, chronic fatigue syndrome, Lyme disease, allergies and eczema. This, however, is just a partial list.

Photodynamic cancer therapy is made possible by the fact that certain substances have absorption spectra that are activated by different wavelength. This amplifies the effect of the natural substance that is used by several folds. For instance Chlorin E6 absorbs a red laser (around 660 nm). A blue laser activates Curcumin. A yellow laser activates Hypericin. Here is a website that explains the principle of phototherapy.

Various cancers can be treated where conventional medicine has so far failed. Examples are lymph metastases from breast cancer, pancreatic cancer, and bladder cancer. I have blogged regarding a combination treatment for breast cancer before, where phototherapy with lasers and immunostimulation were combined. Esophageal cancer is treated through esophagoscopy combined with a laser that activates curcumin, which had been taken orally well before the procedure. Not all of the cases are successful, but the majority of them are.

Otherwise routine low-dose laser applications are used for tendinitis, tennis elbow, sprains and soft tissue injures.

Laser-Therapy-Going-Beyond-Skin-Deep

Laser-Therapy-Going-Beyond-Skin-Deep

You can combine the laser system with prolotherapy. Prolotherapy is done first by injecting hyperosmolar dextrose solution, which is a strong stimulator of stem cells. Using the same needle, but attaching the Weber low-level laser therapy will activate the stem cells and protect them from dying off.

Conclusion

Low dose laser therapy using the Weber Medical technology is a new treatment modality available to the interested physician. I think that it will cause a revolution within medicine. It is scientifically sound and it fits right into the difficult to treat patients; the patients that otherwise would be unlikely to respond. However, they will respond well to these new treatment modalities. Apart from musculoskeletal problems, various cancers will also respond to this. The Mayo clinic is starting a study on treating cancer using phototherapy and the Dr. Weber low-dose laser system.

Jan
30
2015

Prolotherapy And Stem Cell Therapy

This blog is the 5th blog and the last one of a series that dealt with telomeres, lifestyle and stem cells, topics that were on the agenda of the 22nd Annual Anti-Aging Conference in Las Vegas (Dec.10 to 14, 2014). Here are summaries of two talks from this conference that dealt with methods of repairing damage to your joints or bones without surgery. Treatments consist of stimulating local stem cells through a treatment called “prolotherapy” where needles are used to inject concentrated dextrose. I will explain below why this method is effective. A modification of this original prolotherapy is when the effect of it is amplified by growth factors from so-called platelet rich plasma (PRP), which is mixed with the dextrose injection. The ultimate healing jerk occurs when you mix in stem cells with the PRP into the injured tissues. Images before the procedures and images some time after the procedures were shown at both lectures with impressive results.

1. Dr. Fields’ talk was entitled “Repairing joints and spine without surgery: prolotherapy/PRP/stem cell therapy”.

This talk concentrated on the use of prolotherapy with concentrated dextrose and prolotherapy with platelet rich plasma (PRP) with or without the addition of stem cells in the treatment of various musculoskeletal injuries.

When prolotherapy is done by itself 12.5% Dextrose is used to inject into the area of injury. Dr. Fields said that the reason it works is that local stem cells in the injured area are getting activated where the Dextrose is injected and these activated stem cells will do the healing (details explained in an interview with Dr. Reeves). This result can be improved by injecting a small amount of PRP very focally to an area of ligament rupture. PRP is obtained by centrifuging blood from the patient’s vein. The red blood cells are discarded, but the platelet fraction and some of the plasma is used as the PRP preparation. To amplify the effect of the PRP stem cells from bone marrow and from fatty tissue are mixed into the injection. Dr Fields explained that bone marrow is aspirated from the pelvic bone and in the same patient a liposuction is also done to receive adipose tissue. Both tissue samples are put through a cell separator to obtain bone marrow derived stem cells and adipose derived mesenchymal stem cells. Both fractions are combined as they make a superior stem cell mix and are activated by adding platelet rich plasma. This mix was used for bone fractures that were slow to heal, for ruptured tendons, ligaments, Achilles tendons and rotator cuff tears. Dr. Fields showed before-slides and several weeks to months after-slides with MRI scans of the original injuries and the final healed tendons and ligaments. I have never seen such beautiful healing with no residual scar. Stem cells are the specialists of healing such defects because they change into whatever cell type is required and they fill in the defects. This explains the perfect function after the injury is healed following stem cell and PRP injection. It also explains why many athletes who had this done went on to winning more medals after the repair. You do not hear about success stories that often after conventional surgery, because the range of motion and strength suffer from scarring following conventional surgical repairs.

Case histories: several patients with knee injuries that were treated with prolotherapy were shown on video testimonials explaining that their procedures only involved needles in the injured area, that they experienced almost complete pain relief on the day of the procedure and that they could rehabilitate right away.

Slides were also shown of specific knee ligament injuries involving the medial collateral ligament (MCL), the posterior cruciate ligament (PCL) and the anterior cruciate ligament (ACL). These are very important support ligaments within the knee.

But this was not all: there were lower back injuries with ruptured discs. Conventional medicine would have offered a discectomy, but here these patients were treated with prolotherapy. They experienced a stabilization of the weak areas, spontaneous resorption of the prolapsed disc and stabilization and strengthening of the weak spine. MRI scans of the spinal injury before treatment and several months after the treatment were shown with a complete normalization of the spine. In my work as a Medical Advisor for Workers’ Compensation cases that I was doing for 16 years I have never seen a single case like that.

A similar spinal injury in the neck was shown as well with a testimonial from that person. Again there was minimal pain, immediate rehabilitation and a full range of motion several weeks after the injury had been treated with stem cells.

What is treated with prolotherapy?

Basically all of the major joints can be treated with prolotherapy: the shoulder, knee, back, the neck, ankle, elbow and hip. The types of injuries that are treated are sports injuries, fibromyalgia, sciatica, muscle tears, tendonitis, arthritis, bursitis and temporomandibular joint problems (TMJ).

Dr. Fields also stressed (and so did Dr. Purita, which we will learn below) that activated platelet rich plasma needs to be used to activate stem cells.

Two special cases were presented, namely patellar tendinitis and Achilles tendinitis, which both respond very well to prolotherapy and PRP plus stem cell therapy. This provides complete healing of these otherwise very difficult clinical entities.

An image was shown from the late C. Everett Koop, MD, the former Surgeon General of the Untied States who had this to say about prolotherapy: ““I have been a patient who has benefited from prolotherapy. Having been so remarkably relieved of my chronic disabling pain, I began to use it on some of my patients.” This may yet be the strongest argument to at least consider prolotherapy in otherwise hopeless cases.

2. Dr. Joseph Purita gave a lecture on the “Effects of PRP And Stem Cell Injections”. As explained above PRP stands for platelet rich plasma, which is a “soup” of various growth factors and exosomes =cell-to-cell mediators). He discussed the importance of the proper harvesting of PRP. He explained that apart from white blood cells (WBC) and platelets an important component of PRP are very small embryonic like stem cells (VSELs). They can be seen with the microscope. The missing link has been the observation that white blood cells produce inflammatory substances, which have been detrimental when stem cell injections with PRP were done in the past (poor survival rate of stem cells). Now it has been detected that photo-activation of the PRP before injection leads to anti-inflammatory behavior of the WBC in PRP. Dr. Purita calls this “light activated PRP”, which leads to the best results with stem cell/PRP injections. Soft laser stimulation with red, green and blue soft lasers have been shown to improve tissue healing significantly when stem cells and light activated PRP are used. As already described in Dr. Field’s talk the main sources for good stem cells are the fat tissue (from the “love handles”) and the bone marrow (obtained from pelvic bone). Dr. Purita also explained that nitric oxide and electrical stimulation also help to improve stem cell survival and reduce inflammation. All of these methods are revolutionizing orthopedics where injured tissues can be mended with the help of injecting stem cells, light activated PRP and using laser treatments. Dr. Purita showed very detailed technical aspects of these procedures with various applications. For instance, he showed a slide regarding treatment for osteoarthritis of the knee. All this is contained in the plasma that is used to inject PRP into a joint with degenerative arthritis. When you mix this with bone and adipose tissue derived stem cells and inject it into the knees of a person with degenerative arthritis, you get the ideal remedy to calm down the degenerative process with instant pain relief and the stem cells are transforming into cartilage cells (chondrocytes) building up hyaline cartilage. The end result is a new knee surface where the old and the new repaired knee surfaces are knitted into one seamless unit.

PRP by itself can be used successfully for repairing bursitis of shoulders and rotator cuff tears, muscle tears and sprains, meniscus tears of the knee, mild to moderate osteoarthritis of various joints and spine disorders, particularly facet joint problems.

Prolotherapy And Stem Cell Therapy

Prolotherapy And Stem Cell Therapy

Dr. Purita gave a thorough overview of stem cells. He pointed out that stem cells fulfill two criteria:

  1. They are undifferentiated and they are capable of self-renewal by replication
  2. They can undergo differentiation into specific cell lineages.

From a practical point of view as already mentioned in Dr. Field’s talk there are two sources for stem cells that are important: stem cells derived from adipose tissue (also called MCS or mesenchymal stem cells) and bone marrow derived stem cells, obtained usually from the pelvic bone. When they are mixed and stimulated with PRP they are the miracle mix that will help heal all these injuries.

What does the FDA say to stem cell therapy? “The FDA states it is ok to use these cells as long as they are put back into the same patient and they are minimally manipulated.”

Dr. Purita listed a host of other factors beside platelet rich plasma that supports stem cells, increases their survival on transplantation and stimulates them to differentiate and heal the defect at the recipient site as quickly as possible. Photoactivation of platelet rich plasma with low level lasers (soft lasers) will release exosomes, which are tiny particles, released by platelets and white blood cells. They contain proteins and genetic material required for wound healing and stimulation of stem cells.

Towards the end of the talk Dr. Purita showed an MRI scan of a knee with avascular necrosis (dead bone) before and after treatment with stem cells, PRP and low level laser therapy. There was a complete resolution of the avascular necrosis without any surgery. A second case was shown where the initial MRI scan showed a complete tear of the medium collateral ligament (MCL tear) of the knee and the follow-up scan showed the same ligament intact. This was achieved without surgery, just by treating the patient with an injection of stem cells; PRP and using low-level laser therapy to activate PRP.

Conclusion

Prolotherapy and stem cell therapy are the hottest new treatment modalities for ruptured tendons, ligamentous injuries, and disc herniations in the neck and in the lower back. You will not get this from your primary care physician or from your regular orthopedic surgeon at the present time, because they profit from the conventional procedures. But you owe it to your health to try these alternatives first as they are much less invasive and they involve your own cells that will heal the defects with a very high probability. You still have the option to seek the advice of an orthopedic surgeon, should these alternative procedures fail (which is unlikely). Unfortunately most insurance carriers will not pay for this service at this time.

Disclaimer: Dr. Schilling has no conflict of interest with regard to Regenexx or any of the other companies of which images were shown; they simply displayed the best images with regard to the many illustrations in this blog.

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Jan
22
2015

Life Expectancy Is Influenced By Lifestyle

The previous three blogs have dealt with telomeres, stem cells and lifestyle as a theme. In this blog you find summaries from three talks at the 22nd Annual World Congress on Anti-Aging Medicine In Las Vegas (Dec. 10-14, 2014) that dealt with telomere length and how nutrition can positively influence what our genes express, which ultimately determines how long we live. This is at the center of anti-aging medicine and this is why I dealt with it in some detail.

1) Dr. Theodore Piliszek: “Personalized Genetics: Applying Genomics to General Health, Nutrition, and Lifestyle Modification”

The individual’s metabolism is different from one person to the next. As a result of this, one needs to match the diet one recommends for a patient to that person’s genetic make-up.

The Mediterranean diet has 20% protein, 35% fat, 45% carbs; here is the composition of other diets:

Low carb diet: 30% protein, 30% fat, 40% carbs

Low fat diet: 20-25% protein, 20-25% fat, 50-55% carbs

Balanced diet: 20% protein, 25% fat, 55% carbs

Snack only on low caloric foods; otherwise leptins react and make you hungry. A sweet tooth predisposes you to develop diabetes. Lactose intolerance is more common than previously thought. 30% of type II diabetics presently will develop dementia and Alzheimer’s is now often referred to as type III diabetes. With sugar being present in so many processed foods, this figure will likely jump to 60% in the future!

Methylation is very important for your well being. Here is a quick link to explain methylation in simple terms without getting too much into biochemical nomenclature. Having said this, vitamin B2, B6, B12 are needed for this biochemical process, SAMe is also a supplement that supports methylation.

If you do not have a longevity gene, you need to watch that you stick to organic food, stay active, may be add methylated folate and vitamin B12. Each patient should get a supplement list that is customized.

The health practitioner should ask the patient to keep a food diary for 1 week, which gives the doctor the nutritional profile including what the patient consumes in the way of drinks. Check vitamin D3 blood levels! Adequate levels of vitamin D3 are necessary for the musculoskeletal system and the immune system. Endurance training is important up to age 45. Beyond that age emphasis should be on isometric exercises (weight lifting).

Dr. Piliszek stated that the life expectancy in the US is falling behind many other countries. I did a quick Google check regarding life expectancy around the world as follows: US: 78.7 years; Canada: 81.2 years; France: 82.7, Italy: 82.9; Spain: 82.3; Portugal 80.37; Sweden: 81.7; Denmark: 80.05; Norway: 81.45; Germany: 80.89; Poland 76.8; Russia: 70.56. Seeing that the conference took place in the US, there is a lot of room for the US to improve habits with regard to food intake.

Dr. Piliszek stated that the normal range for hemoglobin A1C is skewed in the medical literature and the recommendations are too high; it should be: 3.8 to 4.9 %. This is very important to know for diabetics and any caregiver who looks after diabetes patients, because if you are satisfied with a hemoglobin A1C of 6.0 as still being “normal”, the diabetic patient dies prematurely of a heart attack or a stroke. Contrary to the National Diabetes Information Clearinghouse (NDIC) recommendation it is important to take note: the new normal range for hemoglobin A1C is 3.8 to 4.9%! A patient whose hemoglobin A1C is 5.5 has diabetes and needs to be treated aggressively to prevent complications associated with diabetes.

2) George Rozakis, MD: “Nutrigenomics”

This talk focused on how one could use nutrition to heal when genetic errors are present in the metabolism. This field is called “nutrigenomics”. It deals with using diet modifications and nutrients to change gene expression. Another way to express this is that with proper epigenetic changes by using the right nutrients for a person with an inherited weakness, using the right nutrients for a person with an inherited weakness can extend life. At the same time you need to avoid nutrients that would harm a person with a certain genetic weakness.

We all have inherited some minor or not so minor genetic errors in the genetic code. We are made up of 50 trillion cells with 30,000 genes and 23 pairs of chromosomes, so there are bound to be a few minor genetic code errors that make us more or less susceptible to develop disease, particularly when our telomeres are shortening with age making self-repair of many of our aging cells difficult, if not impossible.

Genes program our cells to run biochemical reactions within the cells. Correct methylation pathways are important for normal cell function. However, if there is a methylation defect, abnormalities set in and homocysteine accumulates.

With various enzyme defects you need to use appropriate supplements to normalize the metabolic defect. Vitamin B2, B6 and B12 supplementation will often stabilize methylation defects and homocysteine levels return to normal. This is important as severe, familial cardiovascular disease can be postponed this way by several years or more.

In a similar vein Dr. Rozakis mentioned that 92% of migraine sufferers have a defective methylation pathway involving histamine overproduction and they can be helped with a histamine-restricted diet.

Autism, ADHD (hyperactivity) and learning disabilities are other diseases where methylation pathway defects are present. Every patient with autism should be checked for methylation pathway defects, and appropriate supplements and diet restrictions can help in normalizing the child’s metabolic defects. DAN physicians (“defeat autism now”) are well versed in this and should be consulted.

S-adenosylmethionine (SAMe) defects are another type of methylation defect, which is important in certain liver, colon and gastric cancers.

Dr. Rozakis went on to say that methylation defects lead to disbalances between T and B cells of the immune system and are important in autoimmune diseases like lupus or rheumatoid arthritis.

Methylation defects can also cause autoimmune thyroiditis and type 1 diabetes. They can also cause cardiac disease by raising homocysteine levels, which causes dysfunction of the lining of arteries and premature heart attacks.

Epigenetic factors through global methylation defects from vitamin B2, B6 and B12 deficiency cause many different cancers. Hypomethylation is the most common DNA defect of cancer cells.

Mental illness is another area where epigenetic factors play an important role. Depression that responds only partially or not at all to SSRI’s (antidepressants) often responds to L-methylfolate, a simple supplement from the health food store as a supplement. Similar epigenetic approaches can be used to treat psychosis, schizophrenia, bipolar disorder and Alzheimer’s disease.

With skin diseases it has come to light that atopic dermatitis, eczema, psoriasis, scleroderma and vitiligo are related to methylation.

When we age, certain hormones are gradually missing, which leads to menopause and andropause. This leads to impaired cell function, elevated cholesterol, arthritis, constipation, depression, low sex drive, elevated blood pressure, insomnia, irritable bowel syndrome and fatigue. Replace the missing hormones with bioidentical ones and symptoms normalize.

Life Expectancy Is Influenced By Lifestyle

Life Expectancy Is Influenced By Lifestyle

3) Dr. Al Sears: “Telo-Nutritioneering: The latest generation of telomere modulators”.

Shortened telomeres are causing cells to behave like old cells. In the lab we can lengthen telomeres. Telomerase activated animals regrew their brains!! In the human situation the goal is to find ways to preserve the length of our telomeres in all our key organs. Alternatively this can also be reached by inhibiting the breakdown of the enzyme telomerase, which will lead to a lengthening of telomeres. In his research Dr. Sears found at least 123 nutrients, vitamins and natural compounds that will elongate telomeres, often by stimulating telomerase.

Testing for critically short telomeres (HT Q-FISH method) is clinically more important than using average telomere length tests. Dr. Sears said when a patient has been shown to have short telomeres and this patient is started on telomerase stimulating supplements, telomere lengthening can be documented within one month of starting the supplementation. Acetyl-L-carnitine and resveratrol are two substances that reliably elongate telomeres.

Vitamin C will significantly delay shortening of telomeres, which translates into delayed aging. In addition vitamin C has recently been shown to stimulate telomerase activity in certain stem cells. There is an herb, called Silymarin extract, which was found to increase telomerase activity threefold. N-acetyl cysteine is a building block for glutathione, a powerful ant-oxidant. In addition it has been shown to turn on the human telomerase gene. Other telomerase stimulators are green tea extract, ginkgo biloba, gamma tocotrienol (one of the components of the vitamin E group), vitamin D3 and folic acid.

Dr. Sears suggested that we should take the following supplements and vitamins for “telo-nutritioneering” (alphabetically arranged) with recommended dosages:

Acetyl L-carnitine: 1,000 mg daily; alpha tocopherol: 400 IU daily; folic acid: 2 mg to 5 mg daily; gamma tocotrienol: 20 mg minimum daily; ginkgo biloba: 40 mg to 80 mg daily (cycle every 4 to 6 weeks); green tea (EGCG): 50 mg daily; L-arginine: 500 mg to 1,000 mg daily; N-acetyl cysteine: 1,800 mg to 2,400 mg daily; resveratrol: 10 mg to 20 mg daily; silymarin: 200mg twice daily; vitamin C: 540 mg minimum daily; and vitamin D3: 2,000 IU daily.

Even if you are only taking 5 or 6 of these twelve telomerase boosters daily, you are doing well, particularly if you are also watching your lifestyle (regular exercise, not smoking, cutting out excessive alcohol intake and avoiding sugar).

Conclusion

This is only the beginning of rethinking epigenetic treatment approaches. For too long organized medicine has used a “cookie-cutter” approach of diagnosing and treating diseases. Now we are realizing that changes in hormones and shortening of telomeres with aging can cause inflammation and premature deaths. The future of medicine, which has already started, uses nutritional changes, vitamins and supplements, bioidentical hormone replacements and exercise to stabilize cell metabolism and postpone age-related diseases.

Dec
27
2014

Stem Cells, Telomeres, Hormones And Lifestyle

I recently attended the 22nd Annual World Congress on Anti-Aging Medicine in Las Vegas (Dec.10 to 14, 2014) and stem cells, telomeres, hormones and lifestyle were the highlights this year. Every year there seems to be something new to learn. There were a lot of talks about stem cell treatments, about how lifestyle changes can be healing and how telomeres are in the center of epigenetics. Epigenetics is anything a person can do with lifestyle to help the body work better. In the center of many talks were telomeres, the small caps at the end of the DNA. With every cell division telomeres get shortened a bit until at the end of our lives our telomeres are significantly shorter. In one talk a slide was shown where the measurements of white blood cell telomeres from blood tests of a population from 20 to 100 years were shown. At the age of 100 the average telomere length was only 40% of the average length of telomeres of the group at the age of 20.

In the past it was thought that our genes and how they function was something constant. Well, we have to rethink this both in positive ways as well as negatively. Using telomere blood tests it has been shown that certain diseases are associated with shorter telomeres. But on the other hand positive lifestyle changes and certain supplements can elongate telomeres by stimulating an enzyme called telomerase. Drinking excessively, doing drugs, smoking and even using non-steroidal anti-inflammatory drugs (NSAIDs) shorten your telomeres. This is what epigenetics is all about. It is true that you cannot change your genetics, but you can change the epigenetics (meaning the length of telomeres).

As this topic is so large, I have decided to give an overview about the conference in this blog and in future blogs provide more details about some of the key talks.

A review like this is always personal. Other people probably would find other talks more illuminating. So here are my personal impressions about the topics that I found most fascinating.

Stem cells

There were several talks about stem cells. Dr. Joseph Purita talked about the rejuvenating effects of PRP (platelet rich plasma) on stem cells that are injected. This was a fairly technical talk, but pointed out how important it is to provide the appropriate growth factors to nurture transplanted stem cells for a long-term success. The sources of stem cells can be from fatty tissue around the “love handles” or the abdominal fat. A stem cell separator is used to separate stem cells from the rest of the tissue. This is combined with PRP coming from centrifuged blood and is combined with the stem cells and injected. The newest insight is that short-term exposure to red, green and blue soft lasers further activates stem cells. Another source for stem cells is the bone marrow, usually from the pelvic bone, particularly for orthopedic surgical problems like non-healing fractures or torn ligaments. Slides were shown of completely healed avascular necrosis following stem cell treatment. At other lectures on prolotherapy combined with stem cell therapy completely torn anterior cruciate ligaments in the knee and a complete rotator cuff tear in the shoulder in another patient were healed (MRI scan shown before and after treatment).

Lifestyle

Dr. David Katz gave a presentation about “Integrative Medicine: A Bridge Over Healthcare’s Troubled Waters”. He pointed out that the first three things on the McGinnis list of actual causes of deaths in the US in 1993 were tobacco use, diet and lack of exercise. In 2004 the revised list no longer contained tobacco as the number one killer. All of the public campaigns had changed the culture of smoking so that the average American has changed the lifestyle. Stopping smoking has become desirable, and people know the devastating consequences of smoking. Dr. Katz stated that there is no magic pill to reduce mortality. However, if a healthy lifestyle were a pill, this is exactly what would reduce mortality by 80%. If you exercise on a regular basis, eat a Mediterranean type diet, and avoid sugary drinks you will prevent 80% of heart attacks, strokes and many cancers.

Telomeres

Dr. Sandy Chang gave a talk about “Telomere measurement as a diagnostic test in cardiovascular and age-related disease”. He pointed out that there is a large body of literature showing that telomere length is directly related to health. The shorter the telomeres are, the higher is the probability to experience problems: early menopause, infertility, diabetes, wrinkles, arthritis, osteoporosis, cardiovascular disease, Alzheimer’s, Parkinson’s, dementia, cancer, stress, a lack of stem cells. These are a number of factors that shorten telomeres: stress, poor diets, smoking, obesity, chronic inflammatory diseases, metabolic disorders like diabetes, over consumption of alcohol and lack of sleep.

Dr. Chang mentioned that there is a whole host of factors that can elongate telomeres by stimulating telomerase. It has been shown in humans that increased physical activity elongated telomeres. So did vitamin C, E and vitamin D3 supplementation, resveratrol, a Mediterranean diet and marine omega-3 fatty acid supplementation. In addition higher fiber intake, bioidentical estrogen in women and testosterone in men, relaxation techniques like yoga and meditation are also elongating telomeres.

Other speakers also talked about telomeres: Dr. Al Sears’ talk was entitled: “Telo-Nutritioneering: The latest generation of telomere modulators”. He mentioned that in his research he has identified at least 123 nutrients, vitamins and natural compounds that will elongate telomeres, often by stimulating telomerase. Vitamin C will significantly delay shortening of telomeres, which translates into delayed aging. In addition vitamin C has recently been shown to stimulate telomerase activity in certain stem cells. There is an herb, called Silymarin extract, which was recently found to increase telomerase activity threefold. N-acetyl cysteine is a building block for glutathione, a powerful anti-oxidant. In addition it has been shown to turn on the human telomerase gene. Other telomerase stimulators are green tea extract, ginkgo biloba, gamma tocotrienol (one of the components of the vitamin E group), vitamin D3 and folic acid.

Dr. George Rozakis gave a talk entitled “Nutrigenomics” where he mentioned that many diseases are due to methylation defects, a cellular pathway that required vitamin B2, B6 and B12. People with this defect have minor genetic variations that lead to elevated homocysteine in the blood. For instance migraine sufferers often have methylation pathway problems, which involves histamine overproduction and 92% of them can be helped with a histamine-restricted diet. Correcting a methylation pathway defect with the help of L-methylfolate can cure other diseases like depressive illness that does not respond to conventional antidepressant medication.

Stem Cells, Telomeres, Hormones And Lifestyle

Stem Cells, Telomeres, Hormones And Lifestyle

Hormone changes with stress

Dr. Thierry Hertoghe gave a lecture on “Burnout: A multiple hormone deficiency syndrome”. He said that burnout is a common condition where several hormones are affected, with the cortisol axis being the main one, but other hormone glands being stressed as well. As a result endocrine glands age prematurely. Symptoms are fatigue, exhaustion, gastrointestinal problems, anxiety, depression and aggressiveness. The underlying hormone abnormalities are a lack of cortisol, thyroid deficiency, growth hormone deficiency, testosterone and estrogen deficiency and oxytocin deficiency. Burnout is common in teachers and there is a questionnaire that has been developed for teachers (teacher’s burnout scale) to monitor them whether they are heading this way. Soldiers who return from combative situations often suffer from burnout or from PTSD. In suspected cases laboratory tests that measure hormone levels give concrete answers about deficiencies. Treatment protocols were discussed in detail. Multiple bioidentical hormone replacements are necessary, possibly for prolonged periods, if not life long. In addition supportive counseling sessions from a counselor or psychiatrist will help to tone down increased brain activity and help regain the internal balance. Why is this important? Because hormones are necessary on a cellular level and regulate the energy metabolism of every cell in the body.

Conclusion

This year’s conference was a very interesting combination of new information on stem cell therapy, telomeres and lifestyle intervention. As we age we lose hormones, which makes us age faster as the telomeres shorten faster. Shorter telomeres lead to inflammation in the body, which cause a myriad of disease processes. This aging process can be countered by adopting a healthier lifestyle with regular exercising, a Mediterranean diet and abandoning unhealthy habits like smoking, excessive drinking or taking illicit drugs. Vitamins and supplements, particularly resveratrol, CoQ-10 and omega-3 fatty acids will help to elongate and stabilize our telomeres. As Dr. Katz said: “A healthy lifestyle will reduce your mortality rate by 80%”.

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