Search Results for: vitamin D

Aug
29
2020

Health Benefits from Vitamin C Supplements

Notably, there are health benefits from vitamin C supplements as I will explain below. A recent publication in the Journal of Intensive Care stated that vitamin C may lower ventilator time for sick patients in the ICU. In this case, researchers performed  a meta-regression analysis. It is important to realize that higher doses of vitamin C changed the need for ventilation. Vitamin C given intravenously or by mouth significantly reduced the need for ventilation in sick patients. To explain, the researchers pooled eight clinical trials and compared them to a control group who did not receive vitamin C treatment. In detail, the researchers noted that there was a 14% reduction with regard to ventilator use in the treatment group. To clarify, they had received vitamin C infusions while patients who did not receive vitamin C infusions served as controls.

Five of the clinical trials involved patients who received 10 hours or more ventilation treatment. Certainly, these patients were sicker than the average ICU patients. They experienced a 25% reduction of ventilator time after receiving between 1 and 6 grams of vitamin C. The physicians gave this intravenous or orally.

History of Mega doses of vitamin C

Indeed, in the 1940’s mega doses of vitamin C were given intravenously in an attempt to treat polio. Eventually, in the late 1960’s Linus Pauling called high doses of vitamin C the “healing factors for diseases”. But subsequent clinical investigations showed that vitamin C had limitations. The Oregon State University website reports that some of the claims about vitamin C in the past went overboard. Here are some points about vitamin C that we need to remember.

  • Vitamin C is an important cofactor in many enzymatic reactions, such as the biosynthesis of collagen, carnitine and neuropeptides. In addition, the regulation of gene expression requires vitamin C and vitamin C is an important antioxidant.
  • A prospective cohort study showed that higher vitamin C blood levels lowered the risk of high blood pressure, coronary heart disease and strokes.

More effects of vitamin C

  • Patients in need of a surgical procedure benefitted from vitamin C. Researchers showed that vitamin C was a valuable adjunct to conventional medicine in cardiovascular disease  Vitamin C reduced arrhythmia and myocardial injury following cardiac procedures.
  • There is insufficient evidence that regular vitamin C intake prevents cancer. Randomized controlled clinical trials reported no effect of vitamin C on cancer.
  • 10 grams per day of vitamin C has no association with toxic or adverse effects in most people. However, some adults are more sensitive to vitamin C and develop gastrointestinal disturbances and diarrhea with megadoses of vitamin C. For these people physicians recommend  taking up to 2 grams per day of vitamin C.

Vitamin C and disease prevention

Several clinical trials involving vitamin C supplements showed significant positive effects on patients. Below I am briefly reviewing these clinical trials.

Endothelial function

Endothelial function was improved with doses of above 500 mg of vitamin C. This likely is the reason that there is a reduction of cardiovascular disease in people who consume 1000 mg of vitamin C daily.

High blood pressure

Vitamin C at 500 mg daily lowers high blood pressure. A clinical trial found that 500 mg of vitamin C daily lowers the systolic blood pressure by 3.84 mm mercury and the diastolic blood pressure by 1.48 mm mercury. Over several years’ time this can prevent premature heart attacks and strokes.

Vitamin C and the immune system

Vitamin C is a powerful antioxidant. It can neutralize reactive oxygen species, which are produced when the immune cells fight viruses and bacteria. Neutrophils, lymphocytes and phagocytes are all supported by vitamin C. Vitamin C and E co-operate in their antioxidant functions. Vitamin C is essential for a strong antibody response with bacterial or viral infections. I take 1000 mg of vitamin C once daily.

Heart failure, strokes and heart attacks

Many studies showed some effects on reduction of heart attacks, strokes and congestive heart failure. With respect to strokes there was a 42% risk reduction over 9.5 years when the highest vitamin C plasma level was compared to the lowest level. But results regarding heart attack prevention and prevention of CHF were only marginal.

Cancer and vitamin C

Stomach cancer: there was a 45% reduction of stomach cancer when high vitamin C plasma level cases were compared to low plasma level cases.

Colon cancer: A pooled study based on 13 prospective cohort studies showed that vitamin C supplementation reduced colon cancer risk by 19%.

Large B cell lymphoma: After 11 years of follow-up the Women’s Health Initiative found that vitamin C supplementation reduced diffuse large B cell lymphoma by 31%.

Researchers could not show significant effects of vitamin C on other cancers.

Type 2 Diabetes (=adult onset diabetes)

A large European study going on for 12 years showed a strong inverse relationship between blood levels of vitamin C and the onset of diabetes. Patients with the highest vitamin C blood levels had a 62% lower risk of developing diabetes. Physicians compared this to low level vitamin C controls.

Mortality reduction with vitamin C supplementation

In the EPIC-Norfolk prospective study a clear inverse relationship was found with higher vitamin C blood levels and a reduction in risk of all-cause mortality.

Recommended dietary allowance for vitamin C

The official dietary recommendation for vitamin C in adults is 90 mg daily for males and 75 mg daily for females. However, in view of the above mentioned clinical trials I would recommend the following. Supplement with 500 mg to 1000 mg of vitamin C daily to have enough vitamin C reserves. The reason I say this is that the official dietary recommendation was based on preventing scurvy, the historic insufficiency disease of vitamin C. In addition, as mentioned before, vitamin C is safe to take up to 10 grams per day. Many physicians recommend taking a smaller amount of vitamin C found to prevent strokes, high blood pressure, type 2 diabetes, improve endothelial function and strengthen the immune system.

Health Benefits from Vitamin C Supplements

Health Benefits from Vitamin C Supplements

Conclusion

In my review I discussed health benefits from vitamin C supplements. Briefly, doctors noted that severely sick patients on respirators in the ICU setting were able to reduce the ventilator use.  This was significant after they received between 1 and 6 grams of intravenous or oral vitamin C. However, patients with the highest vitamin C supplementation had a 62% lower risk of developing diabetes than low level vitamin C controls. Vitamin C lowered high blood pressure moderately and prevented strokes by 42%. Vitamin C stimulates the immune system together with vitamin D, A, E and some trace minerals. There are many more health benefits from vitamin C supplements. The official dietary recommendation for vitamin C in adults is 90 mg daily for males and 75 mg daily for females. However, I take 1000 mg of vitamin C daily as the evidence shows that this is healthier.

Incoming search terms:

Jan
05
2019

Health Benefits of Vitamin E Tocotrienols

Dr. Barrie Tan gave a talk about health benefits of vitamin E tocotrienols that I attended. This occurred at the 26th Anti-Aging Conference of the American Academy of Anti-Aging Medicine in Las Vegas (Dec. 13-15, 2018).

First of all, Dr. Tan stressed that there has been some confusion about vitamin E, as in the past the school of thought was that the main active ingredient of vitamin E would be alpha-tocopherol. Furthermore, many clinical trials with this ingredient go back to the 1960’s, which showed antioxidant activity. But further research revealed that there were many other tocopherols and isomers of tocotrienols. What is worse is that beneficial cardiovascular effects of the newer tocotrienols became null and void through traces of alpha-tocopherol in the mix.

Finally, this led to purer vitamin E production without alpha-tocopherol contamination. Recent clinical trials found that health benefits of vitamin E tocotrienols are linked to delta- and gamma-tocotrienols. They were many times more active in preventing heart attacks and strokes than former mixes of vitamin E.

Annatto derived tocotrienol

In 2002 scientists were able to extract pure tocotrienol without contamination of alpha-tocopherol from annatto. Prior to this vitamin E came from rice and the red palm fruit. But rice contained 50% of tocopherols, while the red palm fruit contained 25% of it.

Here are several sources of vitamin E. The components of tocopherols and tocotrienols vary depending on the source as follows.

Rice: 50% tocopherols (inactive or antagonistic), 15% alpha- and beta-tocotrienols (less active); 35% delta- and gamma-tocotrienols (most active).

Red palm fruit oil: 25% tocopherols, 25% alpha- and beta-tocotrienols, 50% delta- and gamma-tocotrienols.

Annatto: 90% delta tocotrienols and 10% gamma-tocotrienols.

Subsequent research was able to discern between the detrimental effect of alpha-tocopherol and the protecting effect of delta- and gamma-tocotrienols. Now the recommendation of Dr. Tan is to use only annatto-derived vitamin E to prevent heart attacks and strokes. He called annatto-derived vitamin E the vitamin E for the 21st century.

Tocopherol interfering with action of tocotrienols

Dr. Tan explained that alpha-tocopherol blocks absorption of tocotrienols from the gut. It also prevents storage of tocotrienols in liver and fatty tissue. By itself alpha-tocopherol leads to premature elimination of prescription drugs. It also increases blood pressure and cholesterol. What is worse is that alpha-tocopherol increases the risk of prostate cancer and glioblastoma in humans. It also decreases bone mass and increases LDL oxidation, which leads to accelerated hardening of the arteries.

Action of tocotrienols

In contrast to tocopherols, tocotrienols (particularly the delta and gamma isomers) have all the attributes that you want from vitamin E. It has the highest anti-oxidant properties among the tocotrienols. Delta- and gamma-tocotrienols accumulate in LDL cholesterol and in lipid-rich organs like the brain, heart, kidneys, lungs, spleen and skin. Abdominal adipose tissue from obesity also stores delta- and gamma-tocotrienols.

Tocotrienol’s antioxidant activity

When you use a vitamin E preparation consisting of only delta- and gamma-tocotrienols, the portion of vitamin E contained in cell membranes protects against oxidation. Vitamin E  also protects lipids from omega-3 supplements and lipids in foods and beverages from oxidation. Tocotrienols are about 50-fold more potent as antioxidants compared to tocopherols. Based on this information it is not by chance that the following statistics were the results of clinical trials.

Cholesterol lowering effect of vitamin E delta- and gamma-tocotrienols

Dr. Tan cited a 6-week placebo controlled clinical study where the anti-oxidant power was measured in terms of reduction of LDL and total cholesterol.

A group of elderly patients were divided into a subgroup that had normal levels of cholesterol and another subgroup with elevated lipid levels. After 6 weeks of taking a vitamin E preparation consisting of 90% delta tocotrienols and 10% gamma-tocotrienols the blood levels dropped as follows.

Hypercholesterolemic group:    LDL cholesterol    Triglycerides       CRP

                                                          20-28%                11-18%         31-48%

In healthy elderly patients the CRP still dropped 21-29%. Gamma-glutamyl transferase, a predictor for heart attacks dropped by 14-20%.

Another study on postmenopausal women for 12 weeks also showed beneficial effects of tocotrienols.

Hardening of arteries

Dr. Tan explained that hardening of arteries is due to a combination of factors. It is due to combined chronic inflammation and deposits of LDL cholesterol in the wall of the arteries. Studies have shown that monocyte adherence is the first step in fatty streak formation in arteries. Delta-tocotrienol is 60 times more powerful than alpha-tocopherol in inhibiting monocyte adherence. Gamma-tocotrienol is 30 times more powerful than alpha-tocopherol. This proves that taking a vitamin E preparation of 90% delta tocotrienols and 10% gamma-tocotrienols is the most advantageous vitamin E combination to take.

Health benefits of vitamin E tocotrienols include hardening of carotid artery

A 4-year study examined the effect of taking 240mg of tocotrienol-tocopherol supplementation. 88% of patients who took the vitamin E supplement showed improvement (regression of the carotid artery stenosis). Placebo patients deteriorated 60%, only 8% improved. In the 4th year of the study total cholesterol decreased by 14% and LDL cholesterol fell by 21%.

Health benefits of vitamin E tocotrienols include type 2 diabetes

Patients with type 2 diabetes received tocotrienols. Within 60 days of taking 250 mg of tocotrienols the serum total lipids were reduced by 23% and total cholesterol by 30%. The LDL cholesterol was reduced by 42%. Triglycerides were also lowered by 15-20%. C-reactive protein (CRP), a marker for inflammation was lowered between 35-60%.

Beneficial effects of tocotrienols on the eyes and skin

Tocotrienols have antioxidant effects on the eyes and skin. With regard to eye diseases glaucoma and cataracts are improving and macular degeneration in diabetics is responding as well.

The subcutaneous fatty tissue absorb tocotrienols well. Delta- and gamma-tocotrienol largely neutralize oxidative stress from UV light and ozone.

Non-alcoholic fatty liver disease (NAFLD)

This condition has a close association with obesity and the metabolic syndrome. The liver stores excessive fats. About 30-40% of US adults suffer from this disease. Researchers conducted a 12-week study with 71 NAFLD patients. It was randomized, double blind and placebo-controlled. After 12 weeks of supplementation with delta- and gamma-tocotrienol there was evidence of reduction of stress on the liver by improved liver enzymes. The ALT and AST enzymes were reduced by 15-16%. There was also an 11% reduction of triglycerides and 18% lowering of CRP, which indicates a reduction of inflammation. The fatty liver index score showed a decrease of 11%. This suggests that there was intrahepatic fat reduction. The group with delta- and gamma-tocotrienol supplements lost on average 9.7 pounds. Here is another study regarding non-alcoholic fatty liver disease and using tocotrienols.

Health Benefits of Vitamin E Tocotrienols

Health Benefits of Vitamin E Tocotrienols

Conclusion

Vitamin E supplementation is undergoing rejuvenation after research has established that it is delta- and gamma-tocotrienol that are the active antioxidants among the 10 or so tocopherol and tocotrienol isomers. The most active of them, delta- and gamma-tocotrienol, have excellent absorption in the gut and migrate through the blood stream to the lipid rich cells in the body. Key organs like the brain, heart, kidneys, lungs, spleen and skin accumulate vitamin E. Even the abdominal adipose tissue takes up vitamin E, which is beneficial when a person becomes obese or develops diabetes. Apart from lowering triglycerides, total and LDL cholesterol, vitamin E (delta- and gamma-tocotrienol) is also important for directly interfering with hardening of the arteries.

Vitamin E protecting skin, eyes and liver

Vitamin E also protects the skin and eyes against UV light. There can be a partial reversal of tissue damages. Finally, I pointed out that vitamin E can reverse non-alcoholic fatty liver disease (NAFLD). It is important to leave out alpha-tocopherol, which is an older form of vitamin E that is cheaper to produce, but will interfere with the function of delta- and gamma-tocotrienol as explained. As I mentioned earlier, various vitamin E supplements are on the market. It is obvious that they are not equally beneficial.

I recommend you take about 125 mg of vitamin E in the form of delta- and gamma-tocotrienol every day. I take Annatto tocotrienols (Cardiovascular Research Ltd.) 1 softgel daily.

Incoming search terms:

Dec
02
2017

Vitamin K For Bones And Arteries

Vitamin K for bones and arteries is gaining a lot of attention as a valuable supplement. Most of all in the blood vessels, but in addition in the heart, lungs and kidneys the matrix GLA protein is a key substance. Vitamin K2 is crucial for removing calcium from these organs, as matrix GLA protein is carboxylated. Carboxylation of the GLA protein functions much as a broom. This removes all superfluous calcium from blood vessels and organ tissues. If there is a lack of vitamin K2 intake, matrix GLA protein is uncarboxylated, which as a result invites vascular calcification. Essentially vitamin K2 has emerged as an important player in the regulation of bone conditions like osteoporosis, but also in the prevention of hardening of arteries. Vitamin K2 removes calcium from blood vessels and deposits calcium in bone preventing osteoporosis. I will review some key publications, which support this.

Arterial stiffness study in postmenopausal women

Aging blood vessels become stiff from calcification. By removing calcium it seems like the arterial wall becomes more flexible again. Dr. Knapen and colleagues from Maastricht University, The Netherlands followed 244 healthy, postmenopausal women for 3 years in this double blind, placebo-controlled 2015 study.

120 women received 180 micrograms of vitamin K2 (as MK-7) once daily. 124 women received placebo pills. Next researchers checked arterial stiffness through two types of tests. First of all, carotid intima-media thickness was evaluated by echo tracking. In addition aortic stiffness was tested by carotid-femoral and carotid-radial pulse wave velocity. After 3 years there was a significant reduction of uncarboxylated matrix GLA by 50%. This was missing in the placebo group. All of the markers for arterial stiffness showed a reversal improving flexibility above the median. This shows that hardening of arteries in postmenopausal women is reversible with the help of vitamin K2.

Bone metabolism study in Japanese men and women

This 2015 Japanese study investigated what the minimum amount of necessary vitamin K2 would be to improve osteocalcin carboxylation.

First of all, study 1 examined the effect of 0, 50, 100, or 200 micrograms of vitamin K2 (=menaquinone-7) daily. A group of 60 postmenopausal women received vitamin K2 for 4 weeks. Only the 200 microgram per day dosage showed an effect of carboxylating osteocalcin.

Second part of study

Furthermore, study 2 consisted of 120 men and women. Measurements involved the ratio between carboxylated and uncarboxylated osteocalcin to demonstrate the effect of vitamin K2. As a result of study 1 only a placebo group, a 100-microgram and a 200-microgram daily vitamin K2 group was part of the investigation. Both, the 100 microgram and the 200 microgram doses, reduced the circulating uncarboxylated osteocalcin fraction. Hence they concluded that vitamin K-2 effectively keeps the calcium in the bones and prevents osteoporosis. The investigators recommended taking more than 100 micrograms of vitamin K-2 per day to improve osteocalcin carboxylation.

You can find more detail regarding the interaction of calcium, vitamin D3 and vitamin K2 in this link.

Trabecular bone structure preserved in postmenopausal women

148 postmenopausal women were participating for 12 months in a randomized, placebo-controlled, double-blinded clinical trial. All these women had osteopenia. All of them received supplements with calcium and vitamin D3. In addition they received 375 micrograms of vitamin K2 or placebo pills. Examination involved tests for bone mineral density with dual X-ray absorptiometry (DXA). Furthermore a high-resolution CAT scanner determined the microarchitecture of the tibia bone.

After 3 months the uncarboxylated osteocalcin decreased by 65.6% rather than the placebo group of only 6.4% decrease. The trabecular number, spacing and thickness in the tibial bone were unchanged in the vitamin K2 group. In contrast to that there was a clear deterioration of the bone structure in the placebo group.

Summary of trabecular bone study

The bone density studies showed no detectable difference between the groups. The deterioration of the trabecular microstructure in the placebo group was consistent with expected age-related changes. On the other hand, the vitamin K2 group clearly demonstrated preservation of the trabecular bone structure in the tibial bone.

Vitamin K2 helps to eliminate toxic effects of calcium

This 2015 publication from Krakow, Poland explains rather well how vitamin K2 is important to reduce calcium from blood vessels.

At the same time the article points out that vitamin K2 is important for depositing calcium into bones to prevent osteoporosis. The removal of calcium from blood vessels occurs by carboxylation of matrix GLA protein. This functions like a shield to protect blood vessels from calcium entering into the arterial wall. This way the arteries are probably safe from calcification, and hardening of the arteries cannot take place. On the other hand calcium is binding to the bone. As explained above the hormone osteocalcin is responsible for this.Vitamin K2 is the main player in the process of carboxylization. As a result vitamin K2 makes it happen that calcium travels into the bone, where it belongs.

Rotterdam Study: reduced heart attack rates from vitamin K2

4807 subjects from the Rotterdam Study in the Netherlands were part of a study for considerable time (about 10 years) with no sign of any heart attack in the beginning.

The investigators were interested to correlate the effects of various doses of vitamin K1 and K2. How would this impact the frequency of heart disease, hardening of the aorta and all-cause mortality? Researchers adjusted the data for smoking, age, gender, body mass index, diabetes, education, and dietary factors. Next they compared the middle and upper tertile groups of vitamin K1 and K2 to the lower tertile of vitamin K1 and K2.

Results of Rotterdam Study

Most noteworthy, the relative risk for coronary heart disease was lower for the middle and upper tertile of the vitamin K2 group. They found that the middle tertile vitamin K2 intake lowered heart attacks by 27%. It was especially relevant that the upper tertile of vitamin K2 intake lowered heart attack rates by 57%.

In addition, all-cause mortality also showed a reduction for the middle tertile of vitamin K2 by 9% and for the upper tertile by 26%. Finally, severe aortic calcification was 29% less for the middle tertile of vitamin K2 and even 52% less for the upper tertile. Intake of vitamin K1 (=phylloquinone had no impact on any of the outcomes. The investigators concluded that adequate intake of vitamin K2 (=menaquinone) was crucial for anybody’s health. First of all, vitamin K2 lowers heart attack rates, in addition it reduces hardening of the arteries including the aorta and finally, it lowers all-cause mortality.

Vitamin K For Bones And Arteries

Vitamin K For Bones And Arteries

Conclusion

This review shows evidence that vitamin K2 supplementation is important for the prevention of osteoporosis and heart disease. It prevents heart attacks and hardening of arteries, including the aorta. The dosage necessary to achieve this is only 200 micrograms of vitamin K2 per day. However, in Japan higher doses like 375 micrograms per day are the common protocol for prevention of osteoporosis.

Effect of vitamin K2 for bones and arteries

How does vitamin K2 work? In the blood vessels vitamin K2 carboxylates the matrix GLA protein. Essentially this keeps calcium out of the arterial wall and prevents hardening of the arteries. This reduces heart attacks and significantly lowers mortality from heart attacks as well. The second effect of vitamin K2 is on bones. Vitamin K2 prevents osteoporosis to a large extent. It does so by binding calcium to the bone. The hormone osteocalcin, which is carboxylated by vitamin K2 effectively moves calcium from the bloodstream into the bone and keeps it in the bone. If you take vitamin K for bones and arteries, you double the benefit from this simple vitamin. Remember to take 200 micrograms of vitamin K2 daily. The benefits are certainly remarkable!

 

Mar
04
2013

Coffee, Tea, Vitamin C And E Prevent Stroke And Dementia

Introduction

It is important to realize that several studies showed that coffee, tea, vitamin C and E prevent stroke and dementia. Elizabeth E. Devore, ScD, now with Brigham and Women’s and Harvard Medical School, did a long-term study involving 5,395 people aged 55 and older who were part of the long-term Rotterdam Study of medical conditions and other factors in older adults. Notably, over the 14-year observation period 601 patients developed strokes and 599 patients developed dementia. Surely, detailed dietary questionnaires were available from the study that helped the author to detect what the protective factors were in those who did not develop strokes or dementia. Researchers excluded other factors (including tea and coffee consumption) and they studied only antioxidant factors. They noticed that there were no differences in terms of stroke or dementia rates when they compared the lowest and highest percentiles of antioxidant groups.

Tea and coffee consumption protective of strokes and dementia

But when the lowest and highest percentiles of tea and coffee consumers were analyzed and compared, about 90% of strokes and of dementia disappeared meaning that tea and coffee consumption is protective for both.  Dr. Devore explained that other studies have shown that vitamin C helps prevent strokes and vitamin E helps to prevent dementia and that both vegetables and fruit as well as tea and coffee have been shown in other studies to help reduce both.

Here is another article that investigated the role that vitamin E plays in reducing brain aging and preventing dementia and Alzheimer’s.

In a meta analysis vitamin C was shown to help prevent hemorrhagic and embolic strokes.

Coffee, Tea, Vitamin C And E Prevent Stroke And Dementia

Coffee, Tea, Vitamin C And E Prevent Stroke And Dementia

More studies show health benefits of vitamin C, E, vitamin D3, coffee and tea

Vitamin C and E are not the only beneficial vitamins for the brain. Vitamin D3 can help prevent thromboembolic strokes as the Honolulu study going on for 34 years showed.

What about coffee and tea? There is a 10-year study involving 32,600 women where 1 or two cups of coffee per day led to a 25-32% reduction of strokes compared to non-coffee or tea consuming controls.

Black tea and coffee reduced stroke risk

Males also experience a reduction of thromboembolic strokes with tea or coffee consumption. There has been a Finnish study that consisted of 29,133 smokers (smoking 5 cigarettes a day) aged 50 to 69 who were stroke free when entering the study. It ended in 1993 and had lasted for at least 5 years. Drinking two cups of black tea or 8 cups of coffee reduced the stroke risk by 21 to 23%.

Fruit and vegetables contain a lot of vitamin B complex. As this link shows vitamin B can lower cysteine, a blood component that contributes to heart attacks and strokes.

So, what should you do to prevent strokes and dementia?

Stop smoking, if you do. Avoid alcohol and drugs as much as you can. Your brain cells have very sensitive mitochondria that give you energy, but they are very sensitive to toxins. Avoid brain injuries like concussions as they can accumulate and lead to dementia. Whatever you can do for your heart is good for stroke prevention. This includes weight loss (down to a body mass index of 22.0), exercise, and sensible food intake. Sensible food intake includes complex carbs, cut out sugar, have lean meat, more chicken, turkey, lean pork and only occasional beef. Take multiple vitamins including B, C, D3, E and drink tea or coffee. Some health-oriented people may not want to hear this latter point (tea, coffee), but the studies show it is brain and heart protective.

Further information

More information on dementia: http://nethealthbook.com/neurology-neurological-disease/alzheimers-dementia-and-delirium/dementia/

Links regarding the Elizabeth E. Devore, ScD study:

1) http://www.everydayhealth.com/stroke/how-antioxidants-really-protect-against-stroke-and-dementia-3194.aspx

2) http://www.webmd.com/healthy-aging/news/20130220/high-antioxidant-diet-may-not-prevent-stroke-dementia-study-finds

Here is a link to the National Stroke Association about stroke prevention: http://www.stroke.org/site/PageServer?pagename=prevent

 

Mar
01
2007

Check For Vitamin B12 Deficiency In Elderly

Elderly patients frequently are seen at the doctor’s office because they are “feeling poorly”. Concerned family members mention that there is lack of energy, and mental impairment may also be present. Immediately there may be the question, whether these are symptoms of Alzheimers disease. The other observation may be that the older person is not eating properly. Family physicians will order laboratory tests including vitamin B12 levels. If a deficiency is shown, patients will be advised to take a vitamin supplement, and they may receive injections of vitamin B12.
The unfortunate fact is that vitamin B 12 levels are notoriously unreliable in the diagnosis of deficiency. As early as 1988 a publication in the New England Journal of Medicine showed that neuropsychiatric disorder due to vitamin B12 deficiency can be present in a patient who had normal blood levels and no other findings. It does take some other avenues to detect the deficiency. The blood can be tested for the metabolite called MMA (methylmalonic acid) which is raised with vitamin 12 deficiency. A second test is the measurement of HTC (holotranscobalamin), which is the fraction of vitamin B12 bound to the plasma protein transcobalamin, which delivers the vitamin to the tissues of the body.
Dr. Cherie McCracken and colleagues from the department of psychiatry at Liverpool University, England studied 42 men and 42 women ages 69 to 93.They were tested for cognitive functions like orientation, language, attention and memory. In addition researchers took measurements of the MMA and HTC, the tests mentioned above. None of the test persons had dementia due to the selection criteria, but 31% were cognitively impaired. Mental scores indicating cognitive impairment were associated with increasing age and MMA, and the areas of language comprehension, language expression and ideation practice (translating an idea into an action) were affected.

Check For Vitamin B12 Deficiency In Elderly

Check For Vitamin B12 Deficiency In Elderly

The reason for the correlation of MMA with impairment of brain function can be explained by the fact that MMA is toxic to the oxidative function of mitochondria. The process is like a chain reaction: when mitochondria are poisoned, the nerve cells will lack energy for proper function.
Despite this sophisticated interplay of blood levels and cell function in the brain, the message that comes from the researchers is very simple. The MMA has to be ordered as a test in elderly persons, and the next important step is supplementation with vitamin B12 to prevent deterioration in mental functioning.

More information about:

1. Causes of dementia: http://nethealthbook.com/neurology-neurological-disease/alzheimers-dementia-and-delirium/dementia/

2. Pernicious anemia: http://nethealthbook.com/anemia/anemia-from-deficient-red-blood-cell-production/megaloblastic-macrocytic-anemia/

Reference: The Medical Post, January 16, 2007, page 27

Last edited November 2, 2014

Dec
01
2006

Cinnamon And Multivitamins May Boost Fertility

Prenatal vitamin supplements are the norm, as folic acid has been known to play a role in the prevention of neural tube defect. Generally they are taken once pregnancy has been confirmed.
Dr Jorge Chavarro from the department of nutrition at the Harvard School of Public Health in Boston pointed out, that multivitamin supplementation has its place earlier than just after the pregnancy test has become positive. In one of the largest studies involving 18,000 married pre-menopausal women, regular use of multivitamin supplements were associated with a decrease of infertility. The key is in the regular use. Women who took two multivitamin tablets per week had similar infertility rates as women who did not take supplements at all. Those who took 6 or more multivitamins had a 40% lower risk of anovultation, a condition where no eggs are released by the ovaries.
Most of the women were Caucasian between the ages 24 and 42.
The importance of nutrition is coming increasingly into the forefront in reproductive medicine. One condition known as polycystic ovary syndrome (PCOS) is often a reason for infertility. It is one of the red flags that point to the condition of insulin resistance, and it manifests itself in menstrual irregularity and higher levels of androgens, often showing as increased facial hair. As the metabolism is headed for trouble, diabetes, high blood pressure, high cholesterol and heart disease would tend to develop.
Researchers at Columbia University in New York conducted a pilot study to see if insulin sensitivity in women with PCOS could be improved. Cinnamon, a well-known spice, has been known to have a favorable effect on the insulin response of the body. Researchers found that eight weeks of treatment with cinnamon extract significantly decreased fasting glucose and insulin resistance in women with polycystic ovary syndrome.

Cinnamon And Multivitamins May Boost Fertility

Cinnamon And Multivitamins May Boost Fertility

Dr. Jeff Wang who conducted the study reported that no side effects or adverse reactions were reported throughout the study period. If large-scale prospective studies confirm these findings, then recommending cinnamon as a dietary factor may be a simple, inexpensive lifestyle change that can be easily followed. Reducing insulin resistance is a key to improve the overall health status in patients with PCOS, and it ties in with reproductive health benefits as well.

More information about infertility: http://nethealthbook.com/womens-health-gynecology-and-obstetrics/infertility-php/

Reference: The Medical Post, November 14, 2006, page 32

Last edited November 2, 2014

Incoming search terms:

Feb
01
2006

Macular Degeneration Risk Less With Vitamins

Age related macular degeneration (AMD) is one of the more frequent reasons for loss of vision in the ageing population. The disease is also the most prevalent reason for blindness in developed countries.
A group of researchers from the Netherlands made it their mandate to investigate, in which proportion antioxidants were useful in the prevention of AMD. Supplementation with vitamins C, D and E was used and also beta-carotene and zinc. The observations were made using questionnaires from the Rotterdam Study (1990-1993).

The group on which the research concentrated consisted of inhabitants 55 years of age or older living in a middle class suburb of Rotterdam. Of 5836 at the baseline with a risk of AMD 4765 had reliable data of their dietary habits. At the end of the study 4170 participated in the follow up.
Dietary intake of vitamin E and zinc was inversely associated with the development of AMD: the group with an intake of vitamin E and zinc had less macular degeneration than those whose diet was deficient. A higher than median intake of all the four nutrients, vitamin E, zinc, vitamin C and beta-carotene showed even more benefit. The risk to develop macular degeneration was reduced by an impressive 31 %.

Macular Degeneration Risk Less With Vitamins

Macular Degeneration Risk Less With Vitamins

These results are of importance to the ageing population and the elderly. A high dietary intake of the four nutrients is important in the risk reduction of age related eye diseases like AMD.

Reference: JAMA. 2005; 294:3101-3107; Vol. 294, No. 24, December 28, 2005

Last edited December 6, 2012

Nov
01
2004

Not All Vitamins Prevent Cancer

Even in the recent past, vitamins were looked at as an essential weapon to prevent illness, however, a large study by the Cochrane Hepato-Biliary Group at the Centre for Clinical Intervention Research at Copenhagen University has come up with disappointing evidence.

A large evidence-based analysis was performed involving a population of 170,525 persons who were enrolled in randomized trials. They received a regimen of antioxidant supplementation that included beta-carotene, vitamin A, vitamin C, and vitamin E daily or on alternate days for 1 to 12 years, along with selenium every year for 2 to 4 years.
All trials reported the separate or combined incidence of cancer of the esophagus, colon, pancreas, stomach or the liver.
Results showed that beta-carotene alone, the most widely tested antioxidant for cancer prevention, did not have substantial cancer-fighting properties in gastrointestinal cancers. The devastating blow is the fact that beta-carotene in combination with vitamin A and vitamin C significantly increased mortality! Recent studies examining vitamin C show, that it can be an antioxidant, but it also can be a pro-oxidant (the less desirable quality). Trials involving selenium very clearly showed that it might have beneficial effects on the incidence of gastrointestinal cancers.
Following these news it would be a grave mistake to assume, that fruit and vegetables with their built-in antioxidants, micronutrients, dietary fiber and beneficial plant-chemicals have fallen off grace.

Not All Vitamins Prevent Cancer

Not All Vitamins Prevent Cancer

The truth is, that fruit and vegetables typically contain safe levels of vitamins. Most studies have reported that adequate intake of fruit and vegetables are indeed associated with a low incidence of cancer.
The study, however, clearly points out the pitfalls of vitamin supplementation.
-“The more the better” does not apply when it comes to taking vitamins.
-Antioxidants according to this study are not as beneficial for cancer prevention as was thought of in the past.
– Only vitamin C and selenium held up to the scrutiny of the evidence-based researchers with regard to having preventative effects regarding the above named gastrointestinal cancers.

Reference: The Lancet, Vol. 364, Number 9441, pg.1219-28,  October 2, 2004

Last edited December 7, 2012

Mar
01
2004

Vitamins C And E – A Weapon Against Alzheimers

A study in a recent edition of the Archives of Neurology reports about 4740 patients from Cache County, Utah, who were 65 years or older and were followed over 5 years. At the start it was found that those who had taken vitamin C and E on a regular basis as separate supplements had a 78% lesser risk of developing Alzheimers (correct medical term: “Alzheimer’s disease”).

5 years later out of 3227 survivors who were at risk 104 more people had developed Alzheimers, but 64% of those who combined vitamin C and E as a supplement did not develop Alzheimers. Dr. Peter Zandi from the Department of Mental Health, Bloomberg School of Public Health, The Johns Hopkins University/ Baltimore, Md was the lead author of this study. He stated that this was only an observational study, but that the data was convincing enough to warrant a full-scale controlled trial to examine the value of anti-oxidant agents (such as vitamin C and E) as a preventative against Alzheimers. There were a number of built-in controls such as vitamin C alone, vitamin E alone and multiple vitamins (including vitamin C and E in smaller dosages) that were all ineffective in preventing Alzheimers. The daily dosages that were necessary for the protective effect were vitamin C 500mg to 1000 mg or more per day as well as 400 IU to 1000 IU of vitamin E per day. The U.S. recommended daily allowance was insufficient for the protective effect. These dosages typically are in the order of 22 IU of vit. E and 75 to 90 mg of vit. C. Vitamin B complex alone was also ineffective in protecting against Alzheimers.

Vitamins C And E - A Weapon Against Alzheimers

Vitamins C And E – A Weapon Against Alzheimers

Comments: There are many unanswered questions about Alzheimers, but this paper gives valuable hints in terms of the protective effect of two vitamins (vitamin C and E taken as separate supplements daily). There are other factors such as genetic ones and perhaps a dysregulation of the cholesterol brain metabolism that lead to the production of a glue-like substance, called “beta-amyloid” ,that causes memory loss in Alzheimers patients. Testosterone has recently also been noticed to be important in the prevention of Alzheimers disease. In addition to these vitamin supplements a low glycemic, low fat diet would likely be very beneficial together with a regular exercise program and calorie restriction to prevent Alzheimers disease in many patients (prevention of the metabolic disease).

More info on Alzheimer’s disease: http://nethealthbook.com/neurology-neurological-disease/alzheimers-dementia-and-delirium/

Arch Neurol – 01-JAN-2004; 61(1): 82-8

Last edited October 26, 2014

Aug
01
2003

Parkinsons Disease From Too Much Meat And Too Little Vitamin B2

Parkinsons disease (correct medical spelling is ” Parkinson’s disease”) is a degenerative disease of the brain stem that presents with symptoms of shaking, tremor and gait problems.

It is a neurological disease of the elderly and often is a cause of disability leading to institutionilisation. New research at the University of Sao Paulo (UNIFESP) in Brazil has found that a diet rich in vitamin B2 and low in meat has helped to improve patients with Parkinsons disease.

It appears that it may not only be useful in alleviating symptoms of existing disease, but even more importantly to prevent this neurological disorder from developinlg. Dr. Cicero Galli Coimbra stated that in Buenos Aires (where the study was done) the consumption of meat is one of the highest in the world as is the rate of Parkinsons disease. Under his guidance a research team found that about 15% of the population do not absorb vitamin B2 adequately. In combination with excessive red meat intake a significant proportion of the population does not absorb enough of this vitamin resulting in Parkinsons disease.

In this study a group of patients with advanced Parkinsons disease were put on a special diet that included milk (which is a good source of vitamin B2). Other sources of vitman B2 as shown here were cereal, nuts, milk, eggs, green leafy vegetables and lean meat. Within one month 18% of their motor function had returned to normal. After the third month of this diet 60% of the motor function had returned.

Parkinsons Disease From Too Much Meat And Too Little Vitamin B2

Parkinsons Disease From Too Much Meat And Too Little Vitamin B2

Many had improved so much that they were able to drive a car safely again. Riboflavin (=vitamin B2) is an important ingredient in a number of metabolic processes in brain cells that result in the production of dopamine, a brain hormone that is required for regulating muscle coordination in various parts of the brain. This translates into a stable gait, normal muscle strength, good balance and normal cognitive functioning.

These findings were reported in the July 15, 2003 issue of The Medical Post, page 31.

Link to Dr. Schilling’s Net Health Book regarding Parkinsons disease.

Last edited December 9, 2012