Jan
09
2016

Safety Of CT Scans And X-Rays

In the December 2015 issue of the LifeExtension Magazine Mr. William Faloon provided an interesting editorial that discussed the safety of CT scans and X-rays. Physicians often order CT scans to decrease their medico-legal risks or because they own part of the CT scan equipment.

Various publications give estimates of unnecessary CT scans in the order of 30% to 50%.

Brief history of X-ray machine inventions         

Wilhelm Conrad Roentgen, a German physicist was investigating electromagnetic wave lengths and detected electromagnetic waves in the range of X-rays. He won the first Nobel Prize in Physics in 1901 for his achievement.

Marie Curie

Marie Curie and her husband were experimenting with X-rays producing machines and developed the prototype of an X-ray machine that could be used for diagnostic purposes to visualize broken bones or the typical findings of pneumonia or tuberculosis on chest X-rays.

Thomas Edison

Thomas Edison was fascinated by this type of work and invented the fluoroscopy X-ray machine where the doctor could get instant feedback by watching on a screen when a needle was inserted. A helper, Clarence Dally who worked in Edison’s lab developed radiation sickness from X-ray overdoses and died. This haunted Edison for the rest of his life and he quit experimenting with X-rays.

CT scan 

The CT scan was invented in the 1980’s and was immediately used for difficult to diagnose clinical cases. The manufacturer of CT equipment did not advertise that the dosage of one abdominal CT scan was about 400-times stronger than that of a simple lung X-ray. This means that the danger of developing cancer as a late complication due to a CT scan also had a 400-fold higher risk. High sensitivity CT scans using lower X-ray doses have been invented, but they are not always available. It is simpler for the technician to keep the X-ray dose at the higher dosage setting than adjust the CT scanner to the body mass index of patients. A child should not receive the dosage of an adult, but again it is simpler to keep the CT dosage dial in the same setting. This is an unnecessary X-ray overexposure for the patient.

History of cancer complications from radiation

When Mrs. Curie was experimenting with X-rays and radioactive elements she was not aware of the potentially deadly effects of radiation. She died in 1934 at the age of only 67 of aplastic leukemia from unprotected exposure to radiation.

Unfortunately there were many radiation disasters throughout history. This made it clear that X-rays can cause cancer years after the original exposure.

The nuclear bombs of Nagasaki and Hiroshima are ugly reminders how ionizing radiation affects people in terms of getting cancer even years after the initial exposure.

The Chernobyl disaster exposed a lot of people not only in the Chernobyl area (the present state of the Ukraine), but also in Belorussia.

The latest experience comes from the Fukushima disaster in Japan, where authorities initially were slow to respond. Now they have a regular screening in place that identifies youngsters at risk for developing cancers and leukemia.

What all of these disasters have taught medical researchers is that cancerous transformation of tissues can occur even decades after prior exposure. At present there is no safe test that will predict with certainty when a cancer will develop.

Radiation exposure from various X-ray procedures

Because cases of cancer depend on the dosage used for diagnostic purposes, I am going to list dosages for common X-ray procedures, compared to a chest X-ray (modified according to article in the December 2015 LifeExtension Magazine):

Diagnostic             Effective dose (mSv)             Number of Chest               Time to reach dose from                                                          

procedure                                                               X-rays needed to                background radiation

                                                                               get equivalent dose

Chest X-ray                        0.02                                              1                                                 2.4 days

(PA film)

Skull X-ray                           0.1                                               5                                                 12 days

Lower back                          1.5                                             75                                                182 days

Kidney X-rays                      3                                               150                                                 1.0 year

Stomach and

intestine exam                      6                                               300                                                 2.0 years

Colon exam (Barium)           8                                               400                                                  2.7 years

CT scan head                       2                                               100                                                 243 days

CT scan abdomen                8                                               400                                                  2.7 years

You see from this overview that a CT scan generally has a higher X-ray dosage than a plain X-ray, but internal organ X-rays (stomach/intestine and colon X-rays) also use a high dosage of X-rays.

Balance the patient’s need for an X-ray with the risk from it

A CT scan has the ability to image soft tissues, bone and blood vessels, which makes it a useful tool to depict bone fractures, distinguish between hemorrhagic and ischemic stroke and visualize an abscess in the soft tissue. On the other hand there are real concerns about radiation exposure and possible cancer development years after the tests have been done. With any medical procedure physicians have no problems accepting a risk versus benefit analysis. However radiation history showed that physicians were totally oblivious to the possibility of radiation being able to cause cancers until only recently. In the aftermaths of Hiroshima and Nagasaki it became clear that even decades after exposure physicians found new cancer cases among people who had exposure to radiation in the past.

Thyroid cancers in adults often due to radiation exposure in childhood

Most recently with children and adults exposed to radiation from Fukushima it is clear that thyroid cancers are much more frequent in exposed children and adults than in non-exposed controls.

Long-term cancer risk associated with CT scans

Researchers compared over 680,000 children and adults born in the 1980’s. Their physician ordered at least one CT scan. The examiners matched this with a similar large group who never experienced any exposure to a CT scan (Ref.1). The ones who had their CT scan in childhood had a risk of 24% to develop any kind of cancer. If the same person had more than one CT scan the cancer risk was even higher: 35% higher in the first 4 years of exposure; 25% higher at 4 to 9 years and 14% higher still at 10 to 14 years. A group who had their first CT scan exposure 15 years or more ago still had a 24% risk of developing cancer compared to controls who never had a CT scan.

What kind of cancers CT scans cause
What type of cancers did they get? It is a vary varied list: solid tumors in the digestive tract, urinary tract, brain, ovary/uterus, skin and thyroid; among blood cancers they got leukemia and lymphomas. There were also numerous varieties of other other cancers.

Consequences of this data for clinical studies of patients

If follows from this:

  1. If another study is available that can show an abscess, then an ultrasound that does not utilize ionizing radiation would be a superior test to use!
  2. An MRI scan of the brain is superior in stroke patients to distinguish between hemorrhagic and ischemic stroke than a CT scan.
  3. Plain X-rays with less radiation exposure than CT scans often show bone fractures well enough for the orthopedic surgeon to be able to say whether or not a surgical intervention is necessary or conventional management with casts is sufficient. As can be seen from the table above there is 20-fold less X-ray exposure than with a CT scan.

Protection from ionizing radiation

In the fall-out of Chernobyl and Fukushima researchers have gone back to some fundamental observations. There are certain supplements that show cancer protection.

Four plant-derived remedies are useful in fighting radiation damage from CT scans or X-rays.

Blueberries or blueberry extract

Blueberries or blueberry extract has been shown to repair DNA damage from radiation.

Ginkgo biloba

A well-known botanical, ginkgo biloba,  is capable of scavenging free radicals (reactive oxygen species) produced by radiation. Ginkgo biloba can reduce abnormal chromosomes by 60% in individuals who had previously experienced exposure to radiation compared to controls who had not received treatment. During the Chernobyl disaster blood samples from Armenian workers who cleaned up the nuclear reactor had 17.9 abnormal chromosomes per 100 cells; after 120mg of ginkgo biloba for 2 months the cells with chromosome damage showed reduction to 5.7 per 100 cells. These benefits persisted for 7 months, but after 1 year 33% of workers had abnormal chromosomes again.

Lemon balm extract

In the meat industry llemon balm extract is used  to keep meat from oxidizing. There are three stabilizing functions of lemon balm regarding ionizing radiation: it boosts the levels of an enzyme called superoxide dismutase, which is an essential component of the body’s system to protect itself from ionizing radiation. The second effect of lemon balm is to stabilize lipid cell membranes, which prevents direct cell damage following radiation. The third effect of lemon balm is protection of DNA similar to blueberries. In one study radiation technologists were given 1.5 grams/100ml of lemon balm tea twice daily for 30 days. Judging by various cell markers these radiation technicians experienced between 10% and 61% of lower radiation damage on their cells.

Spirulina extract

Spirulina extract stimulates white cell, monocyte and red cell production following exposure to radiation. Research has shown that 4 grams of Spirulina per day for 21 days following the Chernobyl nuclear plant explosion given to youngsters normalized their blood values and they survived. Other research has shown that Spirulina stimulates the granulocyte macrophage colony-stimulating factor (GM-CSF), which stimulates bone marrow precursor cells, the precursors of immune cells.

Safety Of CT Scans And X-Rays

Safety Of CT Scans And X-Rays

Conclusion

The medical profession belittled radiation damage, until the landmark study of 2013 emerged and showed the the consequences described above. Now there is no question that the radiation dosage of CT scans is responsible for the causation of cancer. The decision to order a CT scan requires caution. The physician needs to take into consideration the seriousness of the patient’s condition. Next the benefit of what CT scan findings would show and the risk that this CT scan will impose on the patient needs balance. Alternative non-ionizing tests such, as ultrasounds and MRI scans should be considered.

Minimizing damage from anticipated CT scan

If a CT scan is unavoidable, the physician should tell the patient to take the following. Blueberries, Ginkgo biloba, lemon balm and Spirulina. It is administered at least 5 days before and 5 days after the CT scan. This will minimize the ionizing radiation effect on the body’s tissues. The overall effect is that it will reduce the risk of developing cancer later. It is important for the patient to be informed. Anybody who is told that he or she needs a CT scan needs to talk to the doctor. Don’t be afraid to ask questions about alternative investigation techniques.

References

Ref. 1: Mathews JD et al. “Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians.” BMJ. 2013; 346:f2360.

Apr
30
2014

Overuse Of Supplements Can Create Health Risks

The Dietary Supplement Health And Education Act of 1994 made it easier for people to acquire supplements and vitamins from health food stores. But since then there has been a proliferation of various products that are sold as supplements and not as drugs. It may give you the impression that all supplements are harmless, but this is not so. There are some supplements like vitamin A where you need to watch that you are not inadvertently overdosing, as toxicity is a problem; calcium supplements are also potentially toxic, if overdone. And amino acid supplements (protein supplements) can lead to an overdose of brain hormones. Here is a sample of some of the supplements that I would want you to watch.

1.Vitamin A toxicity:

Vitamin A is essential for normal night vision, for red blood cell production in the bone marrow and for the immune system. Here is a brief review about its metabolism. But while small amounts are beneficial for the body, high doses are toxic. In the 19th century the Arctic explorer Elisha Kane reported that consumption of polar bear liver caused severe headaches, drowsiness, irritability and vomiting within a few hours of ingesting it.

It is now known to be due to “pseudotumor cerebri”, a condition that mimics a brain tumor, but is caused by an acute overdose of vitamin A contained in liver (Ref. 1).

In the US where people eat enough meat, fish and dairy products, there is no overt vitamin A deficiency. Read this link to avoid overdosing with vitamin A in multiple supplements.

Overuse Of Supplements Can Create Health Risks

Overuse Of Supplements Can Create Health Risks

2. Vitamin C:

Vitamin C is an important antioxidant vitamin and is needed as a co-factor for many metabolic reactions. It is participating in the production of collagen and connective tissues, helps with fatty acid transport and is necessary for the synthesis of neurotransmitters in the brain (Ref.2). The lack of vitamin C is known as scurvy; symptoms include bleeding gums from fragile capillaries, delay in wound healing and impaired bone metabolism. Although in the earlier research it was hoped that vitamin C would prevent colds and cure cancer, more recent reevaluations found that it does not prevent you from getting colds, but it accelerates the recovery from colds by cutting down the recovery time by as much as 25 to 30% and it also does have some cancer protective effects (Ref.2). Higher doses seem to be more beneficial, but 1500 mg per day seems to now be the consensus of a reasonable upper dose limit per day.

What about kidney stones? Several studies in the past have warned about vitamin C being broken down in some people into calcium oxalate kidney stones. Here is a brief review of the literature with regard to kidney stone formation. A study regarding the DASH diet, which is used for people with high blood pressure, showed that the incidence of kidney stones is almost half for both men and women compared to controls on a normal North American diet.

There has been a concern among the medical community that vitamin C as a supplement would increase kidney stones (oxalate stones). However a 2014 study showed that when both vitamin C and vitamin E are taken as supplements, the kidney stone formation goes down.

Many inhabitants of industrialized countries including the population in the US and other countries are magnesium deficient and this can be a major factor for forming calcium oxalate stones. But it has been known for decades that those who develop kidney stones excrete more oxalates in their urine (so-called “oxalate excreters”). Here is a 1996 study that measured this in detail.

If you are taking in a lot of green smoothies from green leaf vegetables (spinach, kale, Swiss chard) that are high in water-soluble vitamins, you may not require any vitamin C supplements. In other words, think about what else you do and eat and add it up, so you do not exceed a total of 1500 mg to 2000 mg of vitamin C per day.

If you are taking in a lot of green smoothies from green leaf vegetables (spinach, kale, Swiss chard) that are high in water-soluble vitamins, you may not require any vitamin C supplements. In other words, think about what else you do and eat and add it up, so you do not exceed a total of 1500 mg of vitamin C per day.

3. Calcium supplements:

Calcium is a key mineral in the body, important not only for healthy bone structure, but also to balance the electrolytes within the blood, in the extra cellular fluid space and within our cells. If calcium is low, the brain is more prone to seizures and the heart can produce dangerously irregular heart beats. We definitely need a balance of calcium! Because calcium is so central to our wellbeing, several factors work together to keep our calcium levels stable: the kidneys, the thyroid, the parathyroid glands, the adrenal glands, the bone as a reservoir of calcium, the gastrointestinal tract for absorption and a good, balanced nutrition. The chapter on “Vitamins and Minerals” of Ref.3 points out that 4000 mg of calcium per day definitely causes toxicity (hypercalcemia and milk-alkali syndrome).

Absorption is dose dependent meaning that only 500mg of calcium carbonate is absorbed at a time. Vitamin D3 deficiency leads to reduced calcium absorption. But with high doses of vitamin D3, which is now often recommended, more calcium is absorbed, so it is important not to take too many calcium supplements. They can also interfere with iron and zinc absorption and when more than 2600 mg of calcium is taken magnesium absorption is inhibited as well. Calcium can interfere with thyroid hormone supplements (take 4 hours apart) and may reduce the effect of calcium channel blockers, drugs used for angina or high blood pressure.  There is a balance between calcium stored in bone (99% of total body calcium) and the circulating portion of 1% of calcium in the blood. The parathyroid hormone and calcitonin are also involved in this balance. Hypercalcemia is the condition when calcium is too high. Common causes are the improper use of diuretics (thiazide diuretics), overuse of calcium carbonate supplementation (often for osteoporosis) and overuse of vitamin D3, which increases the absorption of calcium (Ref.3). See your family doctor for blood tests and advice what to do in your case.

4. High protein diets and protein (amino acid) supplements:

Many protein supplements are available through health food stores and vitamin stores. The advertisers often state that our food would be substandard and these supplements would help “to regain strength”.  Athletes hope to get stronger muscles from amino acid supplements because they are the building block for protein that builds up muscles. Fact is that no supplements are needed when you eat balanced meals containing meat and fish and you exercise regularly. The protein in your food will be broken down into amino acids and your body metabolizes this into your own protein. Here is a website that reviews the subject of supplementation with amino acids.

It is clear from this that this is a rather complex problem. Vegetarians may require these supplements to replace protein for the missing meat intake. But the rest of us have to guard ourselves against overdosing with too much meat, amino acids supplements or protein supplements.

High protein diets (Atkins diet and others) have been glorified as being helpful for weight loss. But the long-term effect of such diets lead to chronic kidney damage in those with diabetes and high blood pressure as evidenced by protein leakage in the urine (called ”microalbuminuria”, Ref.4).

According to this reference the average protein requirement is 0.6 g of protein/kg body weight/day. This text comments that this would be compatible with the World Health Organization (WHO) recommendation for protein intake. For a person weighing 140 lbs. this translates into about 50 grams of protein per day. Here is a website that explains the upper limit of meat intake with the example of an 8-ounce portion of top sirloin steak.

Protein supplements have become very popular, but you need to be careful when you supplement with this that you do not get an overdose of amino acids. Amino acid profiling has been useful for physicians and naturopaths to examine deficiencies in children or adults checking for essential amino acids in the blood.  However, in the industrialized countries such as the US, Canada and others the larger concern is now the overuse of meat in our food (e.g. Atkins-like diets) and protein supplements. The same amino acid screening tests will find several of the ingredients (amino acids) in these protein supplements to be too high. In this case it is imperative to stop the protein supplements to prevent amino acid toxicity.

This study warns that not enough is known how performance-enhancing supplements affect the metabolism of the body. There are discussions that perhaps upper limits for amino acid supplements need to be established:

5. Creatine supplementation:

Other supplements of concern are creatine supplementation in the sports-minded and in athletes who want to build up muscle mass. Creatine is synthesized by the liver form amino acids derived from fish and meat that is broken down into the amino acids arginine, glycine and methionine. So, there is no shortage, but athletes and sports minded people want to push the envelope and take in additional creatine that helps their energy metabolism (ATP production) in the muscles to increase their performance (Ref. 5) Creatine is vital for the brain, the heart, the kidneys and the eyes (retina). It is a buffer for lactic acid during anaerobic exercise. Some of the side effects are muscle cramps, diarrhea, fluid retention and kidney failure when exposed to high heat and dehydration. There are no long-term studies of the use of creatine supplements, yet some athletes are taking them long-term.

Conclusion:

We are tempted by various merchants and infomercials to take in more and more vitamins and supplements including protein and amino acid supplements. But when you eat well-balanced meals, preferably organic food, you already have enough protein, nutrients, calcium, vitamin C and vitamin A contained in food. So you may be inadvertently putting a strain on your kidneys that have to eliminate whatever it is that is too much for your body to take. Your liver may also be quietly working overtime as well. Your brain gets overactive by the surplus of amino acids that are utilized by the brain to make brain hormones. Your system can only take so much; at one point a surplus of supplements will make you sick! So, be vigilant and think about what your regular food intake already provides. Do you really need that supplement or do you already get enough from your food intake? Are you falling for some marketing scheme? Remember, you are the steward of your own health!

References:

1.Shannon: Chapter 69: The Vitamins. Haddad and Winchester’s Clinical Management of Poisoning and Drug Overdose, 4th ed.© 2007 Saunders

2. Mandell: “Water-Soluble Vitamins”. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th ed. © 2009 Churchill Livingstone

3. Rakel: Chapter “Disturbances in Calcium and Phosphate” and chapter entitled “Vitamins and Minerals”. Textbook of Family Medicine, 8th ed. © 2011 Saunders

4. “High Dietary Protein Intake” in “Taal: Brenner and Rector’s The Kidney”, 9th ed. © 2011 Saunders

5. DeLee: DeLee and Drez’s Orthopaedic Sports Medicine, 3rd ed. © 2009 Saunders

Last edited April 30, 2014

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Jan
18
2014

The Super Powers Of Vitamin D

Originally, when vitamin D was found to be the missing ingredient in preventing rickets in growing children the recommended daily allowance (RDA) to prevent rickets was found to be 400 IU of vitamin D. The active metabolite has been identified as vitamin D3 for which the body has receptors on all vital organs (heart, brain, bones, kidneys, liver). In recent years new insights have been gained as it turns out that the RDA’s were set much too low for many diseases that can develop when vitamin D intake is too low, particularly in the aging population. Higher doses of vitamin D3 in the range of 800 to 1000 IU per day have been shown to prevent osteoporosis, falls and fractures in older adults and in nursing home populations. But the immune system of everybody is dependent on higher doses of vitamin D3. Recently (Dec. 12 to 15, 2013) I attended a lecture at the A4M conference in Las Vegas where Dr. Eisenstein reviewed the latest on vitamin D3. It is now known that 2/3 of the US population is deficient for vitamin D as measured by blood tests (less than 25 ng/ml).  The standard test is the 25-hydroxy-vitamin D level (abbreviated as 25(OH)D level). It is now known that you require at least a level of more than 40 to 60 ng/ml of 25(OH)D as measured in the US, which translates to more than 100 to 150 nmol/L measured in metric units in other countries, to prevent cancer.

The Super Powers Of Vitamin D

The Super Powers Of Vitamin D

Metabolism of vitamin D3

90% of the vitamin D3 that we need comes from exposure to sunlight, which transforms a cholesterol metabolite (7-dehydrocholesterol) into the vitamin D precursor (vitamin D3 or cholecalciferol). This is what we absorb from naturally occurring fish oil and oily fish, but otherwise this does not naturally occur in foodstuffs (Ref. 1). Dr. Eisenstein pointed out that it is well known that people living north of the 37th degree latitude lack vitamin D3 because of a lack of sun exposure, particularly in the winter season. People south of the 37th degree latitude have enough sun exposure, but wherever you live, it is advisable to have your vitamin D3 level measured (as 25(OH)D level). If you do not eat enough fish or fish oil, the levels likely are too low as is the case for 2/3 of the US population. Vitamin D3 supplements will have to be taken by those whose levels are too low. Vitamin D3 is further metabolized by the liver and then by the kidneys into the active vitamin D compound, called 1,25(OH)2D3 (which is called “calcitriol”). The main effect of calcitriol is to absorb calcium and phosphate from the intestine into the blood stream. Together with vitamin K2 as explained in a prior blog these minerals are then taken up by the bone to prevent osteoporosis or rickets in the growing child. What has not been known for a long time is that vitamin D3 is also necessary for normal cell metabolism by most of your body cells, but particularly by the vital organs like the brain, the heart, the kidneys, the liver, the immune system and the bone. However, doses of 5000 IU to 10,000 IU of vitamin D3 capsules per day are required for optimal vitamin D3 health. This will lead to levels of below 200 ng/ml of 25(OH)D levels, which have been proven to be safe. According to Dr. Eisenstein no toxicity has been found below 30,000 IU of vitamin D3 per day, but based on other authors a dose of 10,000IU should be adequate for most people. Strangely enough colored people also have to take vitamin D3 supplements as their the higher melanin pigment in the skin filters out UV light so effectively that their 25(OH)D level can be low. Always err on the cautious side and have your vitamin D3 blood level taken.

Vitamin D3 has a characteristic stereotactic configuration (cis-triene structure), which allows it to bind free radicals and function as an antioxidant (Ref.2).

What are some of the clinical effects of vitamin D3?

1. Vitamin D3 has diverse effects on organs systems as Dr. Eisenstein summarized: vitamin D3 lifts depression and has been found to be of particular value for drug resistant depression. Take 5000 to 10,000 IU of vitamin D3 per day.

2. Muscle power increases with vitamin D3, particularly in those who work out regularly.

3. Many fertility clinics pay attention to vitamin D3 levels, as the higher the blood levels of vitamin D3 in a man, the faster this sperms move! And the more vitamin D3 she has on board, the better she ovulates. The end result is a higher pregnancy success rate when both partners take 5000 to 10,000 IU of vitamin D3 per day

4. Also, if a woman takes vitamin D3 during her pregnancy, the first set of teeth in the offspring will have fewer cavities.

5. Brain development in autistic children is much improved with vitamin D3 in higher doses. This needs to be combined with detoxification methods and supervised by one of the DAN physicians.

6.Chronic pain typically improves when vitamin D3 deficiency, which almost always is present in patients with chronic pain, is treated with vitamin D3 supplementation.

7. To prevent flus and colds and other infectious diseases, take higher doses of vitamin D3. When you come down with a flu, it is safe to increase your daily vitamin D3 intake to 30,000 IU of vitamin D3 for a few days until your symptoms improve, then resume your maintenance dose of 5000 IU to 10,000 IU per day.  This year’s dominant flu is the type A, subtype H1N1 – also known as the swine flu. Children should get 50% of the dose regimen detailed for adults when they develop a flu (for children: 15,000IU for three to five days , with tapering to a maintenance dose of 2500 to 5000 IU until blood levels of 25(OH)D are available). Here is a website of Dr. Cannell where he discusses dosages as well.

8. Asthmatic patients do better with vitamin D3 supplements requiring less maintenance anti-asthmatic medicine to keep them balanced with regard to their airways.

9. Chronic low vitamin D3 levels cause brain damage including Alzheimer’s disease. In this context it is important to know that the enzymatic conversion in the liver and kidneys slow down as we age requiring higher doses in older patients. This may have been the reason for the confusion about relatively low doses of 400 IU of vitamin D3 preventing rickets in children versus the need of vitamin D3 in middle aged and older patients where much higher doses are required as already explained.

10. High blood pressure is linked to vitamin D3 deficiency and it is better manageable with medication when vitamin D3 levels are normalized.

11. Live longer with vitamin D3. How is this possible, you might ask: the answer has been found in the telomeres, the shoelace like structures at the end of the DNA strand of each cell. Vitamin D3 lengthens the telomeres and promotes telomere repair; this is associated with a longer life span. Centenarians have longer telomeres. You can measure telomere length, but it is a pricey test, which is not for everyone, contrary to supplementation with vitamin D3 that should be taken by everyone!

12. As already indicated, vitamin D3 strengthens the immune system, but it also modulates the inflammatory response from muscle damage, so athletes can perform better. Patients with multiple sclerosis will improve as it slows down the inflammatory process. But other inflammatory diseases like arthritis, inflammatory bowel disease and even cancer will respond favorably to higher doses of vitamin D3 (20,000 to 30,000 IU of vitamin D3 in these cases). This is information that has not yet percolated into mainstream medicine, but will do so in the next few years (or decades?).

13. Higher percentages of cardiovascular disease are found in patients who have lower than 15 ng/ml  25-Hydroxy- vitamin D3 levels in their blood meaning that vitamin D3 supplementation prevents heart disease (Ref.3).

What are toxic vitamin D levels?

What is known about the safety of vitamin D3, particularly the higher vitamin D3 doses? First, it is wise to have your 25(OH)D blood levels taken from time to time. If any of these levels exceed 200 ng/ml it would be prudent to reduce the vitamin D dose or stop supplementation for a while. Otherwise it has been difficult to establish a toxic range.

This website claims that 40,000 IU of vitamin D3 or more would lead to toxic levels where the blood calcium levels would be increased, which can be measured as hypercalcemia. However, another study done in 2007 showed in MS patients that took 40,000 IU per day and that led to a blood level of 400 ng/ml of 25(OH)D did not lead to increased calcium levels and did not lead to hypercalciuria (too much calcium in the urine). So, all of the papers that either indicated to the public that it would be unsafe or unnecessary to take vitamin D3 seem to have other agendas than communicating the truth. Had it been true that calcium would be released from the bones or calcium were absorbed too much from the gut, this would have caused calcification of the bones, soft tissues, heart and kidneys. Also, kidney stones would have developed. However, a low calcium diet combined with corticosteroid drugs usually leads to a full recovery within a month. Interesting that all of the dire predictions regarding toxic vitamin D3 levels did not materialize. Here is another website discussing vitamin D3 dosing.

I talked to a participant of the conference (who has a fellowship degree of the A4M) about what is really known about vitamin D3 toxicity. He told me that there has been an unintentional overdose where a compounding pharmacy made a mistake, so that a patient accidentally received a dosage of 500,000 Units of vitamin D3 per day for a full three months, before the mistake was uncovered. The patient felt sluggish, but did not have any other symptoms. He was told to stop the vitamin D3 compound. He had an uneventful recovery with no detrimental effects. At this point no overdose of vitamin D3 has been established.

Conclusion

Vitamin D3 is a vital supplement that has been shown to prevent not only rickets in children, but also depression, MS, infections and even many cancers (Ref. 4). As usual there will be many critiques that doubt the validity of the above statements. But I have found that all of these effects described above were confirmed in several sources of various medical information. Keep in mind that negative rumours have a tendency to linger on for years.

More information on vitamin D3 for prevention of osteoporosis and hardening of arteries: https://www.askdrray.com/calcium-vitamin-d3-and-vitamin-k2-needed-for-bone-health/

Vitamin D3 deficiency can cause pancreatic cancer: http://nethealthbook.com/news/insufficient-vitamin-d3-linked-to-pancreatic-cancer/

References

1. McPherson: Henry’s Clinical Diagnosis and Management by Laboratory Methods, 22nd ed.,  © 2011 Saunders

2. Rheumatic Diseases Clinics of North America – Volume 38, Issue 1 (February 2012) , © 2012 W. B. Saunders Company

3. Wang TJ, Pencina MJ, Booth SL, et al:  Vitamin D deficiency and risk of  cardiovascular disease.   Circulation 117. (4): 503-511.2008.

4. “Recognition and Management of Vitamin D Deficiency”: American Family Physician – Volume 80, Issue 8 (October 2009),  © 2009 American Academy of Family Physicians

Last edited Nov. 7, 2014