Nov
16
2013

You Can Fight Back Against Arthritis

Osteoarthritis affects about 4 to 5% of the population with women outnumbering men by 2 to 1. The age of onset typically is less than 50 years, but becomes more evident and more disabling beyond the age of 50. About 40 to 60% of osteoarthritis is genetically linked as twin studies in women have shown (Ref.1).

Synonyms for osteoarthritis are degenerative joint disease, osteoarthrosis and arthrosis.

Till recently arthritis was accepted as something that was inevitable: people were getting old, were getting stiff and sore, and had to “take it easy” as a result when they got older. Things are not as uncomplicated, as arthritis affects about 53 million Americans, and it has become the leading cause of disability in the US.

Rheumatoid arthritis is an autoimmune disease. It is not a disease of “old age” but can affect people of every age group. The body reacts to components in joint tissue, and this immune reaction to collagen will produce inflammation, pain and ultimately disability.

So far osteoarthritis was believed to be the result of wear and tear affecting the aging population, but more recently it has been discovered that osteoarthritis is also accompanied by the same inflammatory immune factors that are involved in rheumatoid arthritis.

When the body attacks collagen, which is needed to keep the joints moving smoothly, microscopic particles of it wander into the blood stream. There they are perceived as foreign molecules, and the immune system produces inflammatory substances (cytokines). These are sending out an army of “killer T-cells” to combat the collagen, which is perceived as a foreign matter. They are bombarding the exposed cartilage with toxic substances. This means a chaotic combination of oxidative stress and more inflammation. Over time the cartilage that was meant to protect the joint in its function to move freely is eroded and destroyed. For the person suffering of this disordered reaction, it means that the joint is not only creaking but causing pain, which is made even worse by weight bearing (walking, standing). Any person suffering of osteoarthritis will complain that he or she feels stiff and sore especially after a period of inactivity.

Commercials for anti-inflammatory medication are plentiful, and many sufferers resort to the pain relief that is promised. The warnings are mentioned right after the commercial or on the medication package, if the patient reads the fine print. Most anti-inflammatory medications are causing irritation of the stomach, and the kidneys get damaged (nephropathy)with prolonged use from these pills despite the promises in commercials of a happy, active and pain free life.

You Can Fight Back Against Arthritis

Causes of arthritis

There are many varied causes that can all contribute to developing arthritis.

It is important to take a critical look at lifestyle choices. Excessive body weight puts an additional burden on the joints in the body. Increased body fat is not just sitting at the abdomen as an inert potbelly. Abdominal fat is a highly active metabolic organ that releases inflammatory substances into the blood stream, which distributes them throughout the body. It is known to damage blood vessels. Inflammation will damage the joints as well. The statistics show that 33.8 % of obese women have arthritis. The percentage for obese men shows that 25.2 % suffer of arthritis.

Smoking leads to circulatory problems, and lack of oxygenation in the body’s tissues. It is a mistake to believe that damage is done only to the lungs or the heart. The joints will be affected as well.

Mechanical stress with inadequate self-repair is one cause; misalignment of bones such as knock-knee (genu valgum) and bowleggedness (genu varum) will lead to premature osteoarthritis of the knees as can loss of muscle strength. Exercise without injury does not contribute the risk for developing osteoarthritis; it is actually part of the rehabilitation plan.

According to Ref. 2 there are other causative factors, such as increased age, female sex, race (black women have a twofold increase of arthritis over Caucasian women), estrogen deficiency, nutritional factors, genetics, metabolic and endocrine disorders, joint trauma, joint deformity, occupational factors and sports participation (accumulation of mini injuries).

One of the newer findings is that osteoarthritis is actually an inflammatory condition where numerous destructive processes occur within the affected joints leading to a breakdown of cartilage and supportive synovial fluid factors (proteoglycans). These findings lead to the possibility of new therapeutic approaches discussed below.

Diagnosis of osteoarthritis

According to Ref. 1 there are no blood tests and analysis of synovial fluid is non-diagnostic. Diagnosis of osteoarthritis is made by history, X-rays of the affected joints and clinical findings. There are joint tenderness and swelling of the affected joints. Heberden’s nodes (swelling of the distal interphalangeal joints or DIP joints) and Bouchard’s nodes (swelling of the proximal interphalangeal joints or PIP joints) are present. There can be a decreased range of motion and a grating sound of two ends of bones rubbing together (called “crepitus”).  X-rays show typical osteoarthritis details with a narrowing of the joint space of the affected joint, subchondral sclerosis (increased bone formation around the joint) and new bone formation at the joint margins, called “osteophytes”).

Integrative therapy of arthritis

Ref. 2 points out that integrative treatment of arthritis is aimed at reducing joint pain, increasing joint function and reducing further joint deterioration. Some measures are symptomatic only, others are disease modifying.

Nutrition

Dietary habits can promote good health or have disastrous consequences. The news has been out for some time that the typical North American diet with a high load of omega-6 fatty acids will stoke the fires of inflammation in the body and lead to arthritis, heart disease and cancer. Soybean oil, cottonseed oil and safflower oil contain the cheaper omega-6 oils that are widely used in food processing and bakery products. Refined carbohydrates contribute to unhealthy spikes in blood sugar levels and wreak havoc in their own way paving the downward slope to insulin resistance, metabolic derailment, and diabetes. Take a hard look at your shopping wagon. Stay away from processed foods, shop the periphery of the supermarket, and choose organic meats, vegetables and fruit. Use heart healthy fat in the form of virgin olive oil. A Mediterranean type diet will be a good choice. Just bear in mind, that a heap of pasta like Fettuccine Alfredo does not constitute what a healthy Mediterranean diet is all about. An anti-inflammatory diet such as a Mediterranean diet also includes deep-water fish as a source of omega-3 fatty acids or molecularly distilled omega-3 capsules (you need 7 to 8 high potency, molecularly distilled fish oil, 1000mg per capsule) every day.

This approach has shown beneficial effects in beginning stages of osteoarthritis.

It is important to cut out sugar and starchy foods to reduce insulin resistance, which would otherwise maintain the inflammatory chronic condition causing arthritis and cardiovascular disease. For the same reason cutting out wheat and wheat products has been shown to be beneficial in reducing inflammation. Such an anti-arthritis diet prevents heart attacks and strokes at the same time.

Weight loss

Ref. 2 points out that one study showed that weight reduction of only 10% had a 28% improvement in joint function. When this is combined with an exercise program the improvements are even more striking.

Exercise

Exercise consists of aerobic training, resistance training and muscle strengthening. When patients with osteoarthritis were observed throughout controlled exercise programs, flexibility and range of motion of the affected joints were improving. A minimum of three days per week of exercise was required to show improvements, but the best effects were observed when patients exercised most of the days. Joints become less swollen, show improved circulation and less pain. Before an exercise program is done, those with increased cardiovascular risk should first undergo an exercise stress test to measure their cardiovascular reserve and establish that it is safe to start a program. Secondly, an acutely inflamed or swollen joint should first be treated before an exercise program is started. Lack of exercise will promote more disability. While a person with arthritis may be unable to run a brisk race due to joint discomfort, he or she will find water exercises and swimming much more manageable. Group programs for people with arthritis are available and you may enjoy the supportive company.

Heat and cold therapy

Ref. 2 points out that three weekly 30 minute sessions of microwave diathermy for 4 weeks showed a significant reduction of joint swelling in knee osteoarthritis with improved joint function and reduced pain. On the other hand cold packs for aching muscles after strenuous exercises can decrease muscle spasm and increase the pain threshold. Range of motion increased with cold application and joint swelling was reduced. Patients who have cold sensitivity (such as Raynaud disease) need to refrain from the latter treatment modality.

Acupuncture and electro acupuncture

These treatments were found by Ref.2 to be useful as an adjunct to anti-inflammatory medication with NSAIDS (non steroidal anti-inflammatory drugs); the advantage was that the dosage of NSAIDS could be reduced, which reduced the potential serious side effects of gastric bleeds and kidney damage. Note that people with pacemakers or CNS stimulators cannot use electro acupuncture.

Intraarticular steroid injections

When only a few joints are affected by osteoarthritis (or rheumatoid arthritis), a physician can inject a corticosteroid into the joint. However, there are limitations, as each joint should not be injected more than 3 to 4 times per year. Otherwise there can be damage to the joint cartilage, which would make the arthritis worse. However, I have seen surprisingly good results for a long period of time, which allowed the patients to exercise and stabilize the joints that way.

Complementary treatments

A number of supplements and herbs are effective in reducing inflammation. Omega-3 fatty acids are the precursors for anti-inflammatory prostaglandins in the body, which helps both patients with osteoarthritis and rheumatoid arthritis. As indicated under nutrition above, higher doses are required for this effect and for safety (avoiding toxicity from mercury and PBC’s) molecularly distilled omega-3 fatty acid supplements should only be used (yes, they are more expensive).

Curcumin, the active ingredient of the spice turmeric, has been used in India and Asia for its anti-inflammatory and antioxidant properties for centuries. It helps not only arthritis, but also helps also against the illnesses that are often associated with it (obesity, diabetes, heart disease, autoimmune conditions). Ref. 2 points out that curcumin neutralizes inflammatory agents circulating in the blood of patients with arthritis.

Standardized ginger extract was shown to reduce pain significantly in patients with knee osteoarthritis.

Other common supplements for building up cartilage in the joint are glucosamine sulfate and chondroitin, both available at the health food store. They stimulate glycosaminoglycan formation, which in turn builds up hyaline cartilage, the enamel-like coating of the bone within the joint.

An oral desensitization to treat arthritis

Can joint health be helped in other ways? New answers have emerged. In the past, people who were suffering with colds or flus were consuming a steaming bowl of chicken soup. It should be mentioned that colds and flus are also an inflammatory reaction that occurs within the body.

While a lot of health professionals dismissed this home remedy as old-fashioned and useless, a team of scientist from the University of Nebraska decided to research the matter a bit closer. They discovered that it was not the vegetables, but a component in the chicken broth that showed anti-inflammatory activity. The chicken derived type II collagen functions to regulate the immune system, so it stops attacking proteins normally found in healthy joint cartilage. Results of a pilot study have shown remarkable results. A dose of 40 mg per day of un-denatured type II collagen (UC-II) showed a significant reduction in pain and swelling from arthritis. It also yielded good results in terms of relief from joint pain and stiffness due to exercise.

Animal studies on dogs and horses were also conducted demonstrating that both animal groups that frequently suffer from arthritis got significant relief. Human clinical trials with UC-II showed similar effectiveness.

A group of patients suffering from knee osteoarthritis were treated with the supplement for 90 days. 33% experienced a reduction in their osteoarthritis. The pain was reduced by 40%. Those patients who received the standard treatment without any supplement had 15.4% less pain. Joint function was improved by 20% in the group taking the supplement, while only 6% of improvement was seen in the patient group receiving standard care.

Healthy patients were also assessed who did not suffer of arthritis, but received the supplement to evaluate how they would fare with exercise-induced knee pain. They were treated with a daily dose of 40 mg of UC-II. After day 90 and 120 the group that was treated with the supplement could exercise for significantly longer periods before experiencing joint pain. They also recovered faster after joint pain. The placebo group who swallowed “fake pills” did not show these changes. When knee joint flexibility was examined, the supplement group had significant increases in their knee mobility, but no luck for the placebo group!

Numerous toxicological essays have evaluated the supplement. There is no oral toxicity. No mutations in bacterial genomes have been observed, which is a standard screen to ensure that a substance is non-carcinogenic.

The UC-II supplement works through a mechanism, where the immune system is desensitized by ways of oral administration. It reverses T-cell attacks on exposed cartilage. If our joints are healthy and intact, we normally do not react to our own cartilage. But the protective barrier between blood and cartilage diminishes as we age. Early treatment with UC-II may help induce immune tolerance even in healthy individuals and protect them from reactions of the immune system to their own cartilage.

Conclusion

The supplementation with UC-II offers a different approach to modify joint inflammation of arthritis. Standard treatment at this point consists mainly of symptomatic treatment. Side effects to the drugs can be serious, if they are used on a long-term basis. Few are tolerable to modify the course of the disease.

With the UC-II supplement the root of the disease (autoimmune disease) is being addressed, and relief can be achieved within a few weeks of starting it. With life style changes that were mentioned before and this supplement it is possible to fight back against arthritis!

More information on arthritis: http://nethealthbook.com/arthritis/

References

1. “Osteoarthritis. Basic information”. Ferri: Ferri’s Clinical Advisor 2014, 1st ed., © 2013 Mosby

2.  Rakel: Integrative Medicine, 3rd ed., 2012 Saunders

Last edited Nov. 7, 2014

Aug
10
2013

Bioidentical Hormone Replacement

In many previous blogs I have mentioned that bioidentical hormone replacement prolongs life. Here is a more detailed look at what such hormone replacement looks like for both women and men. Before I get into details I want to stress that I am talking about replacing what is missing and replacing only with natural hormones, not some artificial hormone derivative produced by a drug company. The reason this is immensely important is that hormone receptors in the body are distributed all over our vital organs including bones, blood vessels and the nervous system. If there is no lock and key fit (bio-identical hormone fitting the hormone receptor), there is trouble as the Women’s Health Initiative in 2002 has shown. Unfortunately they had used synthetic hormones for HRT that were not fitting the hormone receptors, and this caused many problems (heart attacks, strokes, osteoporosis, cancer).

Physiology of aging

As we age, we gradually produce fewer hormones in our hormone glands, but the various hormone glands deteriorate in their functions at different rates. Beyond the age of 30 we produce less melatonin and less growth hormone. As a result our sleep pattern may change, as melatonin is necessary for a deep sleep. The decreasing growth hormone production means that we are losing some of our muscle mass and accumulate more fat in the subcutaneous tissues. Our adrenal glands produce less DHEA at the age of 35 to 40, a hormone that is a precursor to our sex hormones in males and females. The gonads (testicles and ovaries) also produce fewer hormones, a process which already starts 5 years before menopause and about 5 years before andropause (the male menopause equivalent).

Typically a woman will get into menopause at the age of 45 to 55 at which time the periods stop and postmenopausal symptoms are interfering with her well-being.  Men get into andropause (the male equivalent of menopause) at the age of 55 to 65 at which time erectile dysfunction occurs and often the individual will become the “grumpy old man”.

Other hormones such as thyroid hormones are also affected by the slow down. Hypothyroidism is common in people above the age of 50.

Bioidentical Hormone Replacement

Bioidentical Hormone Replacement

Baseline laboratory tests

In order to know what is going on, the physician or naturopath needs to order a number of tests to assess whether there is inflammation, how your key hormone levels are; the cardiovascular system markers should also be checked, the liver enzymes and vitamin D3 level. Inflammatory markers are fasting insulin levels and C-reactive protein (CRP). Fasting cholesterol and subfractions (HDL, LDL, VDLP, small LDL) and fasting triglycerides are also measured. Thyroid hormones (T3 and T4, TSH) are measured to rule out over or under function. Typically hypothyroidism is found, which would have to be rectified by taking Armour (a mix of T3 and T4 thyroid hormones).

At this point I need to explain that long time ago the research by Dr. Lee has shown that progesterone hormone levels are notoriously unreliable when blood tests are done. All of the other sex hormones, and cortisol are also not that reliable with blood tests. For this reason the saliva hormone tests have been invented that conveniently report a panel of 5 hormones from one saliva sample: DHEAS (which is the storage form of DHEA), estradiol (the major estrogen in a woman), progesterone, testosterone and cortisol. The saliva hormone tests correlate very well with the actual tissue hormone levels. You can order the saliva tests through Dr. Lee’s website. Another longstanding lab in the US is Dr. David Zava’s lab. In Canada the Rocky Mountain Analytical Lab can process your saliva tests.

Women’s hormone replacement

Let us assume that a woman is getting postmenopausal symptoms and bioidentical hormone replacement is being discussed. The physician will want to first rule out that insulin resistance is not present by ordering a fasting insulin level. If this is normal and the other baseline tests are normal as well except for missing estrogen and progesterone, the physician will usually start to replace progesterone first using a bioidentical hormone cream to be applied once or twice per day. If estrogen levels were also low, the next step in 4 weeks or so is to add Bi-Est, a bioidentical estrogen replacement cream. After 8 weeks of hormone replacement the saliva hormone test is repeated to see whether the estrogen and progesterone levels have come up and also, whether the ratio of progesterone to estrogen is at least 200 or more. Dr. Lee has extensively researched this and found that women with a ratio of less than 200 to 1 (progesterone/estrogen ratio) were more prone to breast cancer. He also stated in this link that there are 3 basic rules with regard to bioidentical hormone replacement:

1. only replace hormones, when they were measured to be low.

2. use only bioidentical hormones (never synthetic hormones) and

3. only replace with low doses of bioidentical hormones to bring hormone levels to physiological levels (body levels that were experienced to be normal before).

Many women who are not replaced in menopause have estrogen dominance meaning that the progesterone/estrogen ratio is less than 200:1, which puts these women at risk of developing breast cancer. Women who are overweight or obese also are estrogen dominant (from estrogen produced in excess through aromatase in the fatty tissue, explained further below), which makes them more prone to breast cancer, uterine cancer and colon cancer. Without bioidentical hormone replacement inflammatory processes take place in the joints (causing arthritis), in the nervous system (causing Alzheimer’s and dementia) and in the blood vessels (causing heart attacks and strokes). Rebalancing your hormones to a youthful state by paying attention to the hormone levels and the hormone ratios mentioned will remove the inflammatory reactions and reduce the risk for cancer.

Men’s hormone replacement

Males enter andropause 10 to 15 years later than women are entering menopause. Typically testosterone production slows down leading to hair loss, erectile dysfunction, loss of muscle mass, osteoporosis and Alzheimer’s/dementia. Blood tests (bioavailable testosterone) or saliva tests are both reliable in determining a deficiency. Replacement with bioidentical hormone creams once per day is the preferred method of treatment. Overweight and obese men produce significant amounts of estrogen through an enzyme localized in fatty tissue, called aromatase.

Aromatase converts testosterone and other male type hormones, called androgens, into estrogen. Estrogen causes breast growth, weakens muscles, and leads to abdominal fat accumulation, heart disease and strokes.

Similar to women, where the progesterone/estrogen ratio is important, there is another ratio for men, called testosterone/estrogen ratio. This should be in the 20 to 40 range for a man to feel good and energetic. Unfortunately many men above the age of 55 have testosterone/estrogen ratios much smaller than 20. This makes them more prone to heart disease and prostate cancer (Ref.1).

However, a male also does need a small amount of estrogen and normal thyroid hormones as well as all of the other hormones for his “hormonal symphony” (mentioned in Ref. 2) to function at his best.

Safety of hormone replacement

There are still otherwise reputable websites that state that bioidentical hormones are not safer than standard synthetic hormones. This confuses the consumer and does not serve the public well. I much prefer the text of the Wikipedia, which is a more thorough review regarding safety of hormone replacement and explains what the issues are.

In the US there is a collective experience of about 25 years on thousands of patients, but there have not been any randomized studies, as Big Pharma that would have the money to finance such studies is not interested in proving that bioidentical drugs would be safer than their distorted synthetic hormone copies that will not fit the body’s hormone receptors. There are some noble exceptions as Big Pharma is producing bioidentical insulin and human growth hormone that had toxicity studies done and showed safety. In Europe bioidentical hormones have been used since the 1960’s, on a larger scale since the 1970’s. So the European experience of safety of bioidentical hormones is presently about 40 to 50 years.

The FDA is contributing to the confusion of the public as can be seen from this publication. One example where the FDA is confusing the consumer, is the progesterone product Prometrium, a bioidentical micronized progesterone capsule that can be taken by mouth. By law the manufacturer had to put a warning label on the package identical to progestin, which is the synthetic, non-bioidentical hormone having been shown to have severe side effects. As is explained in this last publication Prometrium should not have been required to have a warning label in it ; the paper explains what I have already stated above, namely that bioidentical hormones are the safest form of hormone replacement and administered in the right ratios will actually prevent cancer and prevent premature cardiovascular and joint deterioration. In other words, bioidentical hormone replacement can add many years of useful life when started early enough before permanent organ damage sets in from the aging process (which would be due to missing hormones).

Why bother about hormone replacement?

Nature has a plan of “knocking us off” to make room for the next generation. The only way that you can change nature’s plan of killing us prematurely through cardiovascular disease, arthritis, dementia and loss of your sexual life is by bioidentical hormone replacement. Of course you also need the other ingredients of known life prolongers such as healthy (preferably organic) foods, exercise and detoxification. Many women are scared to treat the hormone deficiencies that cause their menopausal symptoms because of the Women’s health Initiative results with synthetic hormones. Men who would benefit from testosterone are often anxious that they may get prostate cancer, when in reality it is the exact opposite: testosterone prevents prostate cancer (Ref.3).

Conclusion

I wrote this blog about bioidentical hormone replacement in order to clarify this often-misunderstood topic. Don’t get confused by the FDA, by highbrow medical websites (such as the likes I mentioned). Big Pharma has a powerful lobby that attempts to keep the medical profession in the belief that their products are better than those that nature has provided (I call it “defend your patent rights”). We are still in a flux state where anybody who tells the truth about hormones gets much criticism. In another few decades it will be an accepted fact and people will wonder why the Women’s Health Initiative was done without a control with bioidentical hormones. With bioidentical hormone replacement you can add about 20 years of youthful life without disabilities to the normal life expectancy. Exercise, detoxification and organic food with avoidance of wheat, starch and sugar can add another 5 to 10 years to your life. The baby boomers are lucky that they have this new tool to prolong life. I wonder whether they will put it to good use.

More information about bioidentical hormone replacement: http://nethealthbook.com/hormones/anti-aging-medicine-women-men/

References:

1. John R. Lee: “Hormone Balance for Men – What your Doctor May Not Tell You About Prostate Health and Natural Hormone Supplementation”, © 2003 by Hormones Etc.

2. Suzanne Somers: “Breakthrough” Eight Steps to Wellness– Life-altering Secrets from Today’s Cutting-edge Doctors”, Crown Publishers, 2008

3. Abraham Morgentaler, MD “Testosterone for Life – Recharge your vitality, sex drive, muscle mass and overall health”, McGraw-Hill, 2008

Last edited Nov. 7, 2014

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Apr
14
2013

Allergies Not Only In Spring

Springtime is the time of spring allergies: those affected develop a runny nose, itchy eyes and in more severe cases they may experience a flare-up of asthma. Allergies can be triggered by the increase of pollen counts in the air that occurs every spring. In those who are sensitive, this leads to antibody formation in the blood. But often people have not only sensitivities to the pollens of spring bloomers; they may also be allergic to spores from molds, to dust mites and may have underlying allergies to foods. The immune system has memory cells that memorize that a person has had an allergic encounter to one of these items in the past, and allergic reactions can become more significant with a future encounter. Allergies can also be made worse when a person has food sensitivities and there are cross reactions between pollens of trees or grasses that can share surface protein regions with similar protein regions in foods.

It is known that cross allergies are possible between birch pollen and apple, carrots or hazelnut. In its extreme form allergies due to antibodies, called IgE antibodies, can cause anaphylaxis. A person presensitized by inhaling birch pollen, after eating an apple, hazelnuts or a carrot can develop itching of the throat, swelling of the lips and very quickly deteriorate getting into an anaphylactic shock.

Other cross allergies exist between ragweed pollen, which is a powerful inhalant allergen and melons or bananas. Again there are specific IgE antibodies that are responsible for this immune reaction. In this case the ragweed allergy primes the immune system to produce IgE antibodies, which are potentiated by certain foods that share similar protein components as the ragweed pollen.

In the following I will deal with inhalant allergies separately from food allergies.

Allergies Not Only In Spring

Allergies Not Only In Spring

Inhalant allergies

Inhalant allergies are easier to diagnose and to treat than food allergies. Your doctor will likely refer you to an allergist when you have allergies that do not respond to treatment with intermittent over the counter antihistamines. Your symptoms may come on in the spring with itchy eyes and a runny nose. From year to year you find that you become more and more dependent on antihistamines and nose drops to unplug your nose. The allergist likely will do sensitivity tests, which consist of skin prick or scratch tests on the back or the forearms.

In more serious allergies, where the patient has coughing and wheezing attacks following allergic reactions, the allergist may suggest to start intermittent allergy injections alongside the standard inhalation therapy for asthma. An allergy serum is prescribed where the lab mixes ingredients based on all of the positive tests that led to a strongly positive skin reactions when allergy testing was done. Typically the family doctor or his nurse will start the allergy injections initially in weekly intervals, later when the maintenance dose is reached, it may be modified to injections every 10 to 14 days.

The allergy injections stimulate the immune system to produce harmless competing antibodies, which counteract the disease producing allergic antibodies. In the process of desensitization shots the immune system will normalize, which means that the inflammatory response of the immune system settles down to normal.

This is not the end of the story with inhalant allergies. The patient needs to be retested on a yearly basis by the allergist. The immune system changes all the time as new allergies can develop and old ones may go away.

Retesting is necessary to keep track of what is going on and to change the composition of the allergy serum. Those patients who are working together with the allergist can do very well, and often they gradually outgrow their allergies. Others may not be so lucky. They may have reactions to the allergy injections. In these cases avoidance of what causes the allergy may be the only solution to treat the allergies.

There is an alternative to allergy injections, which has been used in Europe, namely a sublingual immunotherapy. Recently there has been a review of the literature for FDA approval that is needed for oral desensitization for ragweed, dust mites, grass pollen and cat dander. It will take some time before the FDA approval process will become a reality for sublingual desensitization in the US.

A special form of inhalant allergies are allergies to pets (mainly dogs and cats, but also allergies to petting zoo animals). The dander that the human comes in contact with is a protein contained in the animal hair. It causes hives when it touches the skin. This occurs as the dander is absorbed through the skin and meets the local mast cells that release histamine. This in turn is responsible for the hive formation. Sneezing and even asthma can develop from inhaled protein particles that reach the lungs. Allergy injections for the treatment of animal dander allergies are very limited as they often do not help or make the allergies worse. Avoidance of animal contact is usually what the allergist recommends as the solution, a recommendation, which often is not appreciated by the affected animal lover.

Food allergies

Often we eat  some foods more frequently, because they are our favorites. This means that our gut lymphocytes that get in contact with these foods can start to react to one or more of the foods we ingest. At this time we may experience abdominal cramps, diarrhea, vomiting and a host of other possible symptoms.

The physician will tell the patient that testing for food allergies is a problem as most of the usual skin tests employed for inhalant allergies do not reliably work in determining food allergies. The doctor will ask the patient or the mother of the child with food allergies to keep a food diary and keep track of the allergic symptoms in the diary as well. An elimination diet will have to be devised based on the information gathered in the diary as it becomes clear from that record which foods cause which symptoms. The foods causing allergic symptoms are subsequently eliminated. This is a cumbersome process, but it is the most reliable method of testing and treating food allergies.

In the past there was a blood tests, called RAST test, which tested for common food allergies that can cause severe allergic reactions like egg, milk, peanut, tree nuts, wheat, crustacean shellfish and soy. Since about 2010 this has been replaced by the more sensitive ImmunoCAP Specific IgE test.

Children often develop food allergies to egg, milk, wheat, nuts, peanuts and soy, which are food allergies with positive IgE tests. When they age, their immune system develops tolerance to many of these foods and they often outgrow these allergies.

There are other popular lab tests where a blood drop is analyzed with IgG, IgM and IgE antibodies against a panel of foods. A number of suppliers offer these tests.  However, the specificity, sensitivity and reliability can pose problems with regard to the interpretation of the results: allergists often point out that a test may be a false positive when a person likes certain foods and IgG antibodies against this food show up despite the patient having no symptoms. Another specialist may interpret this to indicate that the body shows early sensitization to a certain food, but clinically it is not yet obvious. In other words the sensitivity of the test is so high that it undermines the validity of the test. Recently a panel of international scientists reviewed the validity of these IgG based food intolerance tests and they found the tests not reliable.

The immune responses to food allergies are complicated as there are immediate type immune reactions and delayed type immune reactions. The immediate immune responses are investigated with the above mentioned ImmunoCAP Specific IgE test. The delayed immune responses can be measured using the ELISA test.

Other considerations about allergies

You see from this discussion that a patient with allergies needs a properly trained allergist who will do a comprehensive analysis involving a thorough history, examination, blood tests and immune tests.  The test results have to be interpreted with the experience and the clinical judgment of the specialist.

Since the 1970’s when Clearfield wheat was introduced around the world on a large scale, which has a much higher gliadin (gluten) content than the old wheat varieties. As a result of exposure to this new type of wheat gluten intolerance and leaky gut syndrome have increased substantially in the world population. Genetically modified foods like soy, corn, sugar beets, canola and more have challenged the immune system of sensitive humans even more to an extent, which is not fully understood yet. We do know that some people can develop autoimmune diseases and this may be the reason that a host of diseases that belong into this disease category (MS, rheumatoid arthritis, Hashimoto’s thyroiditis, ankylosing spondylitis etc.) are much more common now than in the past.

After food elimination for 2 to 12 months depending on the severity of the food allergy, your body may have eliminated the allergy to the food you have avoided, in other words your body built up tolerance. Before you expose yourself to any food that you used to be allergic to and that you want to re-test, it is best to have an EpiPen ready in case your allergy has not resolved. Caution is necessary with regard to foods that cause more severe allergies, e.g. shellfish or peanuts, which may last life long. It is safer to avoid these foods that cause more severe allergies altogether.

Allergic reactions of the immune system belong into the category of chronic inflammatory diseases. These are known to be the root of chronic diseases like asthma, arthritis, heart disease, high blood pressure and cancer. When you are vigilant about allergies and get proper assessment and treatment by an allergist, you will prevent serious health problems including the above mentioned chronic diseases.

More on asthma, which is a chronic inflammatory lung condition, often associated with multiple environmental allergies:

http://nethealthbook.com/lung-disease/asthma-introduction/

Last edited Nov. 6, 2014

Apr
07
2013

Caution, Processed Food Ahead

Introduction

The title of this review is: caution, processed food ahead. During the last month there have been three large studies that drew media attention regarding healthy food intake. The first study dealt with processed meats (sausages, ham, bacon). Over 12.7 years those consuming 160 Gm per day (=5.64 oz.) were 44% more likely to die prematurely than those who ate only 20 Gm (=0.7 oz.) of processed meat per day. The study included 10 European countries including about 500,000 people over almost 13 years; nearly 10,000 people died from cancer and 5,500 from heart problems.

Harvard study 

Then there was the Harvard study that analyzed 114 national dietary surveys around the globe and came to the conclusion that every year there are 180,000 obesity related deaths from overuse of sugary drinks. The US stands third highest on the ranking list regarding deaths from drinking sugary soda pops. The deaths are due to heart attacks, strokes and diabetes, which associate with obesity.

15% of all death around the world from salt overuse

As if this was not enough the third bad news story came shortly after story about salt overuse: At a cardiology conference in New Orleans Dr. Dariush Mozaffarian, the main author regarding the sugar study mentioned above, revealed a long-term study regarding salt intake between 1990 and 2010 .  He determined that 15% of all deaths that occur around the world every year (which translated into 2.3 million people) are the result of salt overuse. The recommended salt limit is 1500 mg per day. But many people in the study consumed 4000 to 6000 mg of salt per day or more. This led to hypertension, heart attacks and strokes with the yearly mortality rates indicated.

Caution, Processed Food Ahead

Caution, Processed Food Ahead

What do these studies have in common and why is processed food so devastating?

All these studies pointed out that processed foods are dangerous to your health. Sausages, ham and bacon contain a lot of fat and salt; they are full of extra calories and they elevate your fatty substances in your blood (triglycerides, cholesterol). The extra salt raises your blood pressure. Processed meat is also poor in omega-3-fatty acids. No wonder that they can cause heart problems and cancer.

Sugar and processed food

Next, we have the sugary soda drinks, but also the hidden sugar in starchy processed foods like cookies, bagels, bread and cakes. Dough and pasta digests within 30 minutes into sugar, which your gut absorbs and your liver processes as extra calories to be stored as fat. Where? As visceral fat and subcutaneous fat, and the end result is obesity. At the same time the sugar from soft drinks and the sugar from starches stimulate the pancreas to produce extra insulin, which leads to hyperinsulinemia and insulin resistance. This is known as metabolic syndrome and was found to be an independent risk factor for heart attacks apart from high LDL cholesterol and high triglycerides. We know for quite some time that obesity, diabetes, insulin resistance and metabolic syndrome are all associated with a higher rate of deaths from heart attacks and strokes.

Salt overuse

Finally, there is the salt overuse story. In 2009 the same Harvard group that gave us the world data on salt mortality now, stated that 102,000 Americans die every year from salt overconsumption. The same study cited that 82,000 Americans die needlessly every year due to their love affair with deep fried foods (due to high trans fatty acids) , and 84,000 die from a lack of omega-3-fatty acids in their diet, which when present in the diet protects from heart attacks and strokes.

Food processing

What does food processing do? It reduces or eliminates dietary omega-3-fatty acids, adds cheap oils containing omega-6-fatty acids (the fatty acids that lead to inflammation), adds salt, sugar and starch. It is the perfect recipe to die from strokes and heart attacks. The same research group from Harvard University did a study in India, published in 2010, where they established that salt over consumption caused insulin resistance and this was the cause of higher mortality from heart attacks and strokes.

Other studies pointing to the dangers of processed food

Deficits in cognitive function (dementia or Alzheimer’s disease) are associated to dietary habits, particularly sugar and starch overconsumption. Research has established that hyperinsulinemia or insulin resistance is responsible for the degenerative changes in the brain of Alzheimer patients. This study also pointed out that these diets are typically very low or deficient in omega-3-fatty acids, which is necessary for normal nerve cell metabolism in the brain. The lack of it leads to brain cell disease like Alzheimer’s and a lack of omega-3 fatty acids in nerves leads to damaged nerves which in turn cause excruciating pain.This condition is also known as neuropathy.

Gout was around in the Middle Ages

In the Middle Ages it was first observed that overindulging in red meat and sausages caused gout attacks. A nickname for gout was “a disease of the rich”. Higher uric acid levels, which are found in gout have been linked to higher mortality rates from heart attacks and stokes. A low purine diet can lower the risk for gout and also the risk for heart attacks and strokes. It is interesting that this type of a diet is also devoid of processed food at the same time.

What can we do to reduce dangers to our health?

We have identified the suspects; it is sugar, starchy foods, salt and processed meats. Instead of just buying precooked meals, boxed foods and other processed foods from the center of the grocery store or from a fast food place, look for original ingredients more at the periphery of the grocery store.  Read food labels and look for sugar, fat and salt content. Start buying organic food and buy the ingredients you need to prepare a meal by yourself. When you start preparing your own meals with organic ingredients, you may as well avoid the toxins that I described in a recent blog.

Buy organic foods

By buying organic foods, you largely avoid these toxins. Don’t exceed your daily limit of 1500 mg of salt, as your kidneys are not able to process this and would cause you to get high blood pressure. Personally, I cut out all sugar and starch from my diet since 2001. This includes potatoes, pasta, bread, bagels, French fries, toast etc. However, you will get enough complex carbohydrates (from vegetables and greens). The body absorbs them much slower and does not cause the insulin surge by the pancreas. In contrast, highly processed carbs lead to an insulin surge.

Omega-3 fatty acids important for health

You want to eat foods rich in omega-3-fatty acids, but seafood (even salmon) has a contamination with mercury. You can circumvent this by taking 3 or 4 capsules of high potency, molecularly distilled omega-3 per day. This is free of toxins and protects your brain and nerves from the dangers mentioned above. Your organic vegetables/greens have enough natural minerals that you will seldomly want to add salt to your food. Do not add extra salt when you cook or when you eat your prepared meals. Use spices instead. Also avoid eating out too often. Restaurants are notorious for overusing salt.

More information

More information on nutrition: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/

Here is a useful blog that helps you to identify the problems with processed food: http://www.healthy-eating-politics.com/processed-foods.html

Other links:

1. Processed meat: http://www.huffingtonpost.com/2013/03/07/processed-meat-cancer-heart-disease-death-risk_n_2829092.html

2. Sugary drinks: http://www.cnn.com/2013/03/19/health/sugary-drinks-deaths/index.html?hpt=he_c2

3. Alzheimer’s and pre-diabetes with insulin resistance: http://www.usatoday.com/story/news/nation/2012/10/17/carb-diet-alzheimers/1637481/

Feb
19
2013

Forget The Glass Of Red Wine For Good Health

We have been hearing for over 10 years that 1 glass of red wine per day for women and 2 glasses of red wine per day for men would be recommended in order to prevent a heart attack or a stroke. Now we are confronted with new research from Boston showing that even small amounts of alcohol are bad for you as alcohol is a carcinogen (=cancer producing substance). Misinformation like this occurs when science concentrates only on one angle of health, such as cardiovascular disease prevention and the other part of the equation, the cancer producing (carcinogenic) effect of alcohol, is disregarded.

In 1996 this Australian study followed 1236 men and 1569 women 60 years and over for more than 5 years and studied their mortality rates as a function of alcoholic drink intake. The authors found that there was a short-term protective effect with regard to cardiovascular/stroke mortality. But due to the fact that mortality was the end point for both cardiovascular disease and for cancer, the study was mostly taken as evidence that alcoholic beverages would protect to a certain degree from strokes and heart attacks. The authors were aware that alcohol was cancer causing as they stated, “Those taking any alcohol exhibited an increased proportion of deaths due to cancer at the expense of a reduced proportion of CHD and stroke deaths”. But this part was not mentioned in the popular press or in future alcohol/cardio-protective recommendations. The authors also were aware that the observation time of 5 years was on the short side. We know from other studies that alcohol toxicity requires a longer observation time such as 15 to 20 years or longer to show significance in a multitude of cancers.

Forget The Glass Of Red Wine For Good Health

Forget The Glass Of Red Wine For Good Health

As already mentioned above, recently a new survey of alcohol-caused cancer was published and went through the popular press. Dr. Timothy S. Naimi from Boston University Medical Center was the main investigator of an international team of scientists. The study found that every year 18,200 to 21,300 cancer deaths in the US (that is 3.2% to 3.7% of all US cancer deaths) are directly caused from alcohol consumption. The authors of the study determined that every person who dies from alcohol related causes lost on average approximately 18 years of his/her life (scientists call this “years of potential life lost”).  51% of women developed breast cancer from alcohol exposure, 62% of men came down with upper airway and esophageal cancers. Less than 1.5 drinks per day caused between 26% and 35% of alcohol-related cancer deaths. There was no safe lower margin. The authors concluded, “Reducing alcohol consumption is an important and underemphasized cancer prevention strategy”.

Interestingly, in 2006 other research looked at alcohol caused cancer cases in the world based on WHO data and came to the conclusion that with the increased worldwide consumption, particularly in East Asia, preventative steps by eliminating or replacing alcoholic drinks would be wise.

A recent study in 2012 where cancer rates in the US were compared between Hispanics and Caucasians showed that Hispanics had higher rates of stomach cancer, liver cancer, uterine/cervix cancer and gallbladder cancer. The authors concluded that Hispanics need more screening done such as Pap tests and that effective vaccines (like Gardasil) should be used. In addition effective interventions should be applied to reduce obesity, curtail alcohol consumption and reduce tobacco use.

Studies have shown that there is no safe level of alcohol consumption, not even the famous 1 drink for women and 2 drinks for men (with regard to heart attack prevention), because cancer incidence increases with increasing alcohol consumption in a linear relationship.

What does alcohol do in the body that it is so dangerous to your cells? Many cancer researchers have researched this question in detail. Essentially, alcohol is by itself a toxin for your cells (the targets being sub particles in your cells called microsomes and mitochondria). Your liver metabolizes alcohol into acetaldehyde, your kidneys excrete it and your lungs exhale it (this is how a breathalyzer can detect how much you have been drinking). All of these chemical changes in your cells release free radicals, which in turn attack other cells. This sets up a chronic inflammatory process, which breaks down your immune system, leads to cell mutations and finally to cancer.

What protects you from cancer?  It is the antioxidants that stabilize the above-mentioned processes: vitamin C, glutathione, vitamin D 3, curcumin, multiple vitamins, magnesium, flavonoid foods, cruciferous foods (like broccoli), exercise and soluble fiber.

So, if you were serious about cancer prevention, you may want to stop any alcohol intake and take the above supplements instead. The heart attack and stroke protection will be achieved by flavonoid foods (perhaps specifically adding resveratrol 250 mg per day as well) and exercise.

If you were less conscientious about cancer prevention, at least reduce your alcohol consumption perhaps to the occasional glass of wine or beer, but avoid high percentage spirits and remember, the less the better! You may be toasting to ill health with that glass of wine. Say no to false advertising of the wine industry! Your body will thank you for it.

More information on alcoholism: http://nethealthbook.com/drug-addiction/alcoholism/

Here is another reference where you can read about the recent Boston study:

http://www.physbiztech.com/news/ceasing-alcohol-consumption-leading-way-prevent-cancer-death-study-finds

Last updated Nov. 6, 2014

Jan
22
2013

Long-Term Multistep Weight Management

In February of 2001 my wife and I attended an anti-aging conference in San Diego. The keynote speaker was Dr. Barry Sears who is the inventor of the zone diet. We had read a book from him before the conference and were excited to hear him speak in person. We liked the book; we liked the talk, so we cut out sugar, starchy foods and stuck to a diet where the calories derived 50% from low-glycemic, complex carbohydrates, 25-30% from lean meat, poultry and fish. Calories derived from fat were reduced to about 15-20% (there is hidden fat even in lean meat). No butter, but instead some lean cheeses and olive oil for cooking and in salad dressings. We shed both 50 pounds within 3 months without any hunger pangs. Our energy increased and this has stayed  this way ever since. There was no problem getting down with our BMI’s (body mass index) to 23.5 or 24.0, which is usually viewed as normal by the medical profession. We noticed, however, that when we did not exercise, there was a problem maintaining our normal weight.  We are under the care of an anti-aging physician who did special tests like fasting insulin, C- reactive protein, and hormone tests. They were all normal. We took up ballroom dancing really seriously having been inspired by “Dancing With the Stars”. This was 6 years ago. What started innocently with only a few basic ballroom lessons three times per week has now blossomed into dancing more than 10 different dance styles 5 times per week.

Long-term Multistep Weight Management

Long-term Multistep Weight Management

3 ½ years ago both of our energy levels were slowly going down, particularly after a long night of dancing. Hormone tests revealed the initial stages of age-related hormone deficiencies which did not come as a surprise , as  decreasing hormone levels was a topic discussed  in detail at the conference in San Diego in 2001 (we also attended several other anti-aging conferences on a yearly basis from 2009 onwards). With bioidentical hormone replacements these levels normalized within one year, our energy was back and our weight stayed normal. We enjoy travelling, but there can be problems with our multistep weight management program. We need to watch our diet (no toxins, preferably only organic food), and physical exercise may be less regimented. In 2008 we read Suzanne Somers’ book “Breakthrough”. We ordered urine tests for toxic metals and we were shocked that we had noticeable levels of mercury and lead. Since then we started to cut our salmon consumption from 3 to 4 times per week down to once or twice per week. To get rid of the heavy metals we started intravenous chelation treatments with vitamin C (10 Gm) and Glutathione (1250 mg) every two weeks. In July 2012 there were reports of radioactive salmon from the Japan nuclear disaster earlier that year in the Canadian media. After this news we stopped eating all fish and other seafood, not only because of radioactivity, but also because of other toxins like mercury, cadmium, PBC’s etc.  We do take high doses of molecularly distilled omega-3 fatty acids along with our other supplements. We also started eating mostly organic foods as we do not want to ingest insecticides, herbicides and other toxins.

We acquired body composition scales, which give information about fat percentage including visceral fat percentage, muscle mass percentage, BMI, weight and the basic metabolic rate. We wanted to define the end point of what our ideal body weight would be. We noticed that our dance program was not good enough to lower the BMI below about 23.5; using the body composition scales we noted that our body fat content was still too high and the visceral fat percentage was still in the 6% range. It took a prolonged trip to the US where we could not find enough dance events to decide that we would introduce a one hour gym program consisting of 30 minutes of treadmill, 15 minutes of upper body circuits, and 15 minutes of lower body circuits every day as a basis to our exercise program. Any dance activity would be just an additional exercise on top of the base exercise from the gym. It took only about 2 months before our fat composition decreased, our muscle mass increased, the visceral fat went to a normal at 5% and the BMI was now stabilized at the 21.5 to 22.0 range. We feel a lot more confident in managing our weight long-term without really thinking much about the weight. It is now a routine we follow, like an athlete would do to stay in shape. While nobody has a permanent guarantee to everlasting health, we do it to prevent the diseases we do not need in our retirement like diabetes, arthritis, heart attacks, strokes, cancer or Alzheimer’s.

What we did not know until after the 20th A4M Anti-Aging Conference in Las Vegas (mid December 2012) was that inadvertently we were protected from exposure to chemically modified wheat from 2001 onwards as we had cut out all refined carbohydrates and starchy foods (including wheat) since then. Unfortunately many Americans still expose themselves unknowingly to larger or smaller quantities of wheat, suffer from leaky gut syndrome with the associated changes in the immune system and the development of autoimmune diseases.

Personally, I believe that long term weight management is possible: you can turn older and hopefully wiser…not wider. The good news: it can be done. The bad news: this is not an instant fix, but a program that needs to be part of your lifestyle package.

More information on weight loss: http://nethealthbook.com/health-nutrition-and-fitness/weight-loss-and-diet/

Last updated Nov. 6, 2014

Oct
01
2008

Lifestyle Can Be A Killer For Middle Age Women

Generally it is assumed that persons in their thirties and forties should be in their prime, and health concerns are cropping up in the higher middle age or only in old age.
Also, women were thought to generally enjoy better health and life expectancy, but the large Nurses’ Health Study on 77,782 women in the age group of 34 to 59 years shows other aspects.
Even in females who had no heart problems and no cancer at the onset of the study, lifestyle choices can make it or break it. At the end of the study that spanned 24 years, it became obvious that a total of 28% of all the mortalities could be attributed to smoking. If risky lifestyle choices were combined in the form of smoking, being overweight, having a lack of physical activity and a qualitatively poor diet, this number jumped to 55%. Alcohol intake did not change this estimate significantly.

Lifestyle Can Be A Killer For Middle Age Women

Lifestyle Can Be A Killer For Middle Age Women

It is obvious that for the benefit of better health and less mortality in middle age women, diet, exercise, a healthy body weight and eradicating smoking are key factors.

Reference: BMJ 2008;337:a1440

Comment on Nov. 18, 2012: So how many years longer will a woman live, if she quits at age 30? The Million Women Study found out that she will live 10 years longer than the control group of smoking women (see link). Nothing has changed since 2008. Lifestyle issues remain at the forefront.

Last edited December 3, 2012

Mar
01
2006

Knowledge Needed For Herbal Remedies

Herbal remedies have stood the test of time, and today roughly 80% of the world’s population relies on traditional medicines for primary health care needs. Herbal remedies and their efficacy have been confirmed in research, but nevertheless caution is necessary.
Not all herbal preparations are equal. Herb potency can differ due to growing and storage conditions. Toxic contaminants can be present in herbal preparations, and the best way to ensure a quality product is to purchase a product from a quality controlled source.

Anybody using herbal products should bear in mind that “natural” does not mean “harmless”. Many plants like catnip, juniper, lobelia, jimson weed, wormwood and nutmeg can inhibit the parasympathetic nervous system significantly and cause severe hallucinogenic effects. Patients with allergies to asters, chrysanthemums and ragweed should avoid teas from goldenrod, marigold, yarrow, St. John’s Wort and chamomile, as there is the possibility of cross-reactivity. Comfrey, which is a commonly used folk remedy in Europe and North America, has been shown to contain pyrrolizidine alkaloids, which causes liver damage and cancer in animals and in humans.
There is a common notion that herbal teas that are used as laxatives would be entirely safe. Unfortunately it is not as simple as that. The continued use of cathartics (herbs that are laxatives) can be dangerous, as they cause a dependency or the so-called lazybowel problem.
If herbs are used it is important to be vigilant to negative interactions with medications. St. John’s Wort interferes with cyclosporin, digoxin, epileptic drugs and indinavir. Gingko should be used with caution by patients who are on warfarin (a blood thinner) because it can cause excessive bleeding. Deaths have been associated with the use of ephedra.
It is also of importance that herbal remedies should not been taken during pregnancy, unless the safety of taking them has been assured. To get qualified information the consumer should beware of flashy headlines promising miracle cures and seek the advice from a licensed health professional who is properly trained in the prescription of herbs.

Knowledge Needed For Herbal Remedies

Knowledge Needed For Herbal Remedies

It is also of importance to mention the use of herbal medications along with other medications that are used in order to assure the therapeutic benefits for the patients who uses them.

Reference: The Canadian Journal Of Diagnosis, January 2006,page 35 and 36

Last edited December 6, 2012

Feb
01
2006

Chronic Pain A Cancer Risk

Chronic pain can be an undermining force in people’s well being. Often it is more perceived as a nuisance or an inconvenience. How serious it really is as a health risk, has been emerging only in more recent observations.
Two well designed, population based studies in the UK are showing that there is an increased risk in people with chronic pain to die prematurely or to develop cancer.
In a study by J. Mc Farlane, MD individuals with chronic back pain or patients suffering of fibromyalgia show an increased risk for premature death and cancer. Often pain sufferers have not only one pain condition but also multiple ones. Mc Farlane quoted an excess risk of 30% for premature mortality in pain patients. At the same time he states that the risk is “relatively modest”. Another study noted that patients who suffered of widespread pain over a 10-year period had a 50% increased risk of developing cancer than those who were pain free at the baseline. Statistically it means that 2.5% of patients with widespread pain over a time of 10 years will develop cancer, which remains a small percentage.
The author notes that there is no reason to feel overly threatened by these results. More research will tell more. For the practical application the results point to the need for effective treatment and pain control before chronic pain patterns become detrimental to the patient’s health.

Chronic Pain A Cancer Risk

Chronic Pain A Cancer Risk

More information on:

Pain can affect many areas:  http://nethealthbook.com/neurology-neurological-disease/pain/

Cancer risks: http://nethealthbook.com/cancer-overview/overview/epidemiology-cancer-origin-reason-cancer/

Reference: The Back Letter, December 2005,Vol.20, Nr.12, page 139

Comment on Nov. 11, 2012: Chronic pain can indicate that the patient may be hormone deficient. When hormones are tested, some patients may be hypothyroid, others may lack steroid hormones like testosterone, estrogen, progesterone or DHEA as is normal with the aging process. In these cases often restoration of the hormone balance with bio-identical hormones can treat the pain condition successfully and can prevent cancer by restoring normal immune function.

Last edited October 30, 2014

Jan
01
2006

Face Transplants For Disfigured Patients

Patients with severe burns to their face have been treated with skin transplants in order to help them cope with common body functions which the average person takes for granted, like opening and closing of eyelids or breathing. Patients have to undergo numerous skin grafts, where skin is transplanted from other body areas. The process can take years, as multiple surgeries are needed. Facial skin is also more tender and pliable, making it different from the type of skin in other areas of the body, and plastic surgeons are working to make the facial appearance of the patient less mask-like. The journey to recovery becomes a long and difficult one, which can be likened to an emotional roller coaster: there is surgery and the time to heal, after which more surgery is required.
The possibility of a face transplant sounded like a futuristic item till a short time ago, but French doctors have used new techniques to restore the facial features of a 38-year-old woman, whose face had been mauled by a dog. The partial transplant was done using the mouth, nose and chin of a brain dead donor.
Maria Siemionow, the director of plastic-surgery research at the Cleveland Clinic states, that facial transplant can only be considered as a treatment for severely disfigured patients who have exhausted all conventional options. The procedure itself remains controversial and risky. It involves harvesting the face from a brain-dead organ donor in a 4 to 6 hour surgery. In the following 10 to 15 hour procedure the face is draped over the bones and muscles of the recipient. Following surgery the transplant patients needs to take medication to prevent the rejection of the transplant. Even though the risk is not any different than the risk, which goes along with a kidney transplant, there is the possibility of transplant rejection and of side effects from immunosuppressants. Patients, who take this medication that will cost about $2000 per month, are more susceptible to infection, cancer, metabolic disorders, and liver and kidney damage. The psychological impact on the patient will also be significant, as there could be a feeling of having a different identity. Dr. James Zins, chairman for plastic surgery at the Cleveland Clinic, insists that there are no races to be won and the approach to this new option should be methodical and slow.

Face Transplants For Disfigured Patients

Before and after face transplant

Not all potential candidates for the surgery are willing to take the risk of life-long immuno-suppressants and it is only a consideration for physical as well as psychologically suitable patients who are willing to take the risk of receiving a new face after devastating accidents.

Reference: December 12, 2005 issue of Newsweek, pages 60-61

Last edited December 6, 2012