Jun
08
2013

Breast Cancer Due To Stress

The medical profession is of the opinion that breast cancer is multi-factorial, where genetics, body weight, hormonal and other factors play a role in causing it (details see Ref. 1). The Wisconsin Longitudinal Study (United States) showed in May 2012 that girls from families of lower socioeconomic status have a higher risk of breast cancer later in life. The study also showed that girls from families with a higher socioeconomic status had a low risk of breast cancer later in life.

The same cohort of women was the subject of another study, which was just published in April of 2013. In this study the question was asked whether stress in career women could cause a higher rate of breast cancer. Using 1957–2011 data showed that 297 of the 3682 White non-Hispanic women of the Wisconsin Longitudinal Study developed breast cancer. Details of the study showed that the peak of the age for breast cancer to develop was around 55 to 65. Women working with the lowest job authority had the lowest rate of breast cancer. High job authority, being the “boss”, was associated with a 1.57-fold (range 1.12 – 2.18-fold) increase in breast cancer. There was also a striking difference between the lengths of job stress exposure, 5 years versus 15 years with both groups, high and low job authority. The lowest risk of breast cancer was for the low stress group of women who worked under these conditions only for 5 years, followed by the same group who had worked there for 15 years. Slightly above that latter group was the breast cancer risk for the 5-year employed high job authority. The highest group of breast cancer risk, rising above all other groups, was the group with high job authority, exposed to this for type of stressful situation for 15 years (see Fig. 1 of the above link). The researchers interpreted their data to say that the majority of the breast cancer risk in these groups of women was due to the stress hormone (cortisol). Minor contributions were thought to be due to the carcinogenic effect of estrogens.

Breast Cancer Due To Stress

Breast Cancer Due To Stress

 

Review of the literature regarding this study

Dr. Lee had been publishing about estrogen dominance for many years (Ref. 2 and 3). When women age, their ovaries do not produce as much progesterone during the luteal phase as in younger years and above the age of 30 to 35 anovulatory cycles are common. During anovulatory cycles ovulation (=release of an egg) does not occur and there is no formation of a corpus luteum that would produce progesterone for 2 weeks. The end result is that there is a lack of progesterone as a woman ages. This has been discussed in detail in Ref. 3. Dr. Lee called this disbalance of estrogen and progesterone “estrogen dominance”. This is one of the important causes of breast cancer as explained in Ref.2. This can be caused by aging, xenoestrogens from exposure to artificial fertilizers, insecticides and cosmetics, but also taking the birth control pill for prolonged periods of time. However, stress by itself can also produce a state of estrogen dominance. Dr. Lee explained (page 180 of Ref. 2) that the cortisol-binding globulin (CBG), which binds both cortisol and progesterone, is a storage form for both of these hormones. As a person is under chronic stress the CBG is increased binding both cortisol and progesterone. This means that less of these hormones are preliminarily available in their free form for body consumption as CBG binding is a storage form for these hormones. The free progesterone, which is the only biologically active progesterone portion, is lowered as a result of stress causing estrogen dominance. If estrogen is not opposed by progesterone, it is cancer causing for breast tissue and the uterine lining, which translates into being at risk for breast and uterine cancer. Only supplementation with bioidentical progesterone cream as described in Ref. 3 will rebalance the hormones (progesterone/estrogen balance) and reduce the cancer risk. The symptoms of estrogen dominance according to Ref. 4 (p. 29) are fatigue, weight gain, less ability to handle stress, headaches, mood swings, loss of sex drive, irregular periods, uterine fibroids, fibrocystic breasts, fluid retention (particularly around the ankles), irritability and depression.

Practical recommendations for women in stressful jobs

Above the age of 35 it is wise to have a saliva hormone test done, checking the levels of 5 hormones (cortisol, DHEAS, estrogen, progesterone and testosterone). This establishes the baseline values for these hormones. The relationship between the levels of these hormones determines whether they are balanced or not. For instance, if the ratio between progesterone and estrogen (divide the level of progesterone by the level of estrogen) is less than 1 in 200 the patient has estrogen dominance (see Ref. 5). You may need to get a naturopathic physician or an A4M physician who is knowledgeable in interpreting these results and treating the patient with bioidentical hormones. Some women may need to start bioidentical hormone replacement at this point if a hormone deficiency is noticed.

In order to counterbalance stress you need to schedule some time for yourself regularly where you can relax, do yoga exercises, meditation, and/or self-hypnosis. Make sure you get enough sleep. Avoid alcohol, if you can as it interferes with a restful sleep, or reduce alcohol to the absolute minimum. Alcohol causes decreased hormone production of both ovaries. It also weakens the adrenal glands contributing to hormone disbalance. Usually the first hormone to show a decline with stress and aging is progesterone. It has to be measured by the saliva test. Ref. 2 and 3 explain why: progesterone is fat-soluble and is transported through the blood in its free form through red blood cells. However, a progesterone blood test measures the serum progesterone level after the red blood cells have been spun down in the centrifuge, which leads to misleading results; only the saliva test gives reliable results in terms of bio-available progesterone levels. Many conservative physicians blindly insist on blood progesterone levels, which will lead to false results. This is why you need a naturopathic physician or A4M physician to help you with the proper interpretation of the test results.

If saliva progesterone levels are low, progesterone cream (bio-identical, as explained below) is applied daily in a concentration that will normalize the levels. Physicians who have been influenced by drug company representatives may suggest to use Provera (or another progestin, which are synthetic hormone substances) as a “supplement”, but this is known from the Women’s’ Health Initiative to cause breast cancer, heart attacks and strokes.

Do the proper monitoring tests with saliva testing and only substitute what is missing with bioidentical hormone creams. Otherwise a low fat, low refined carbohydrate diet, exercise and other good health habits as I have summarized in this link will be very beneficial to prevent stress as a cause of breast cancer. Ref. 6 is also a useful text written for the layperson explaining what to do when stress leads to adrenal fatigue.

References

  1. A review of the causes of breast cancer: http://www.nethealthbook.com/articles/causesofbreastcancer.php
  2. Dr. John R. Lee, David Zava, Ph.D. and Virginia Hopkins: “What your doctor may not tell you about breast cancer”. 2002 Hachette Book Group, New York,NY, USA.
  3. Dr. John R. Lee: “Natural Progesterone”.  2nd edition. Jon Carpenter Publishing, 1999 Charlbury, England.
  4. George Gillson, M.D., Ph.D.: “You’ve hit menopause. Now what? 3 simple steps to restoring hormone balance” 2nd edition, 2004, Rocky Mountain Analytical Corp., Calgary, AB, Canada.
  5.  John R. Lee, M.D. and Virginia Hopkins: “Dr. John Lee’s Hormone Balance Made Simple- The Essential How-to Guide to Symptoms, Dosage, Timing, and More”. Wellness Central Hachette Group USA, New York, NY 10017. Published 2006. Page 57 discusses saliva testing and states: “The healthy ratio of progesterone to estradiol is at least 200 to 1 and can go up to 1,000 to 1 in women using transdermal (delivered through the skin with cream, gels, oils) progesterone.”
  6. James L. Wilson, ND, DC, PhD: “Adrenal Fatigue, the 21sty Century Stress Syndrome – what is it and how you can recover”; Second printing 2002 by Smart Publications, Petaluma, Ca, USA

Last edited Nov. 6, 2014

May
05
2013

Get Rid Of Toxins Safely

You often hear that chelation could be done effectively using home remedies. Is that true?

The standard chelation detoxification

I like to mention in the beginning that the proven way to reduce heavy metals in the blood (typically mercury and lead) is by intravenous chelating agents such as EDTA. However, the lowering of calcium levels as a severe side effect limits the application of it. There are also blood-thinning side effects to consider. EDTA is a chemically synthesized compound, not a natural substance. Conversely, vitamin C and Glutathione are both antioxidant substances that the body knows; they are non-toxic and can be used more easily intravenously to remove heavy metals like lead and mercury with fewer side effects than EDTA. Although I think that EDTA has a place in the hands of those who are knowledgeable about the side effects, the vitamin C/Glutathione combination is probably a more physiological detoxification method as glutathione is synthesized by the liver to detoxify our bodies. Intravenous chelation is expensive, requires access to a vein and may not be a suitable way for many people to detoxify. There are natural ways to detox for those who cannot afford chelation or cannot chelate for other health reasons.  The major detoxification organs are: the liver, the kidneys, the gut, the lungs and the skin.

What about oral methods to detoxify?

Several methods of cleansing are fasting, the major cleanse or the raw food cleanse. I would not advise to do strict fasting without fluid intake as it takes fluid intake to be able to dissolve any released toxins into urine, feces, invisible fluid from exhaled air and nasal discharge. Next there is the “master cleanse” with lemon juice, maple syrup and cayenne pepper as indicated in the link above. Some people like trendy procedures that are written up in a magazine or in a self-help book. I do not like it, as it reminds me too much of a cookbook approach.

I feel differently about a raw food cleanse as I will explain. First, I like to point out that raw food is not easily digested as your gut absorbs only about 30 to 40% of the nutrients. The cell walls of the vegetables you use are the barrier towards absorption. This is much different, if you put the raw fruit and vegetables into a blender with a high power motor. (There are several brands like the BlendTec or the Vitamix.) The powerful blending process breaks up the cell walls and releases the content of the plant cells including their enzymes and nutrients, so that 80% of the nutrients are absorbed in your gut.

Get Rid Of Toxins Safely

Get Rid Of Toxins Safely

If you use organic ingredients (they do not contain toxins, artificial fertilizer residues etc.) you cannot go wrong! Use spinach, kale, banana, mango, greens, lemon juice, and for fat add some nuts like walnuts, Macadamia nuts, almonds (provided you are not allergic to them). With the help of a powerful blender all this will turn into a liquid drink that actually tastes OK. For protein supplementation I would also add some protein supplement like vegan protein from the health food store, whey protein or egg white protein (good to rotate these protein supplements). This mix is a complete nutritional program as it contains complex carbohydrates from fruit and vegetables, fat from nuts, protein from the protein supplement and fiber (from the whole vegetables and fruit). You will not get hunger pangs as with a fast or the master cleanse. Use the signs of your body as guidance. If you feel energized after 5 days, stop then and return to your normal food intake (zone type diet, a Mediterranean diet or South Beach diet as explained below). Some people have the will power to do 7 to 10 days of the liquid diet described. Good for them, at least they do not starve themselves as the calories and total nutrient content are there while they detoxify. What are the agents that lead to the detoxification process? It is the enzymes released from the fruit and vegetables, the lack of toxins as you only consume organic ingredients , the extra vitamin C from the food and the glutathione contributed from your liver that are working together.

Are there supplements that can help you to detoxify?

Chlorella powder, which you can buy in health food stores, is one of the few supplements that can detoxify your body from heavy metals. As Dr. Mercola describes that in Japan chlorella powder is one of the most popular supplements to detoxify. It is difficult to get a complete, non-biased picture about chlorella. I did an extensive research in MD Consult about the scientific evidence for detoxification by chlorella in humans. Unfortunately the search results came back only for experiments with mice and rats, but there were no human detox results. Perhaps the Wikipedia description about the history of algae and chlorella as a possible food supplement sheds some light on the difficulties getting real hard data on chlorella detoxification. In rats that were deliberately poisoned with cadmium (a heavy toxic metal) no convincing detoxification with chlorella could be detected when cadmium poisoning was stopped. However, the article goes on to say that chlorella did prevent absorption of cadmium from the intestines to a certain extent (in rats).

Liver detoxification and colonic detoxification

Dr. Max Gerson invented coffee enemas many years ago when he treated end stage cancer patients with natural methods. He found that when he detoxified them with raw juices, many cancer patients died from the toxic breakdown products of dying tumor cells. So he was in dire need of a procedure that would remove the toxic tumor substances efficiently.  This is when coffee enemas were used. As the link above describes, coffee given through the colon as an enema (we would perhaps call it “coffee colonics” today) stimulates the liver and the bile flow thus detoxifying the blood effectively of toxic materials. In addition the secretory capability of the large surface of the colon wall also helps the detoxification process. Juicing in combination with coffee enemas improved Dr. Gerson’s end stage cancer cure rates dramatically. Subsequently, Dr. Kelley developed his nutritional-metabolic therapy for end stage cancer patients where he added large amounts of pancreatic enzymes in addition to coffee enemas. Dr. Denis Burkitt is credited for recognizing the importance of fiber in the diet. He noticed that there was a striking difference between the colon cancer rates in England versus the rates in Africa. He analyzed food habits and came to the conclusion that back home there was not enough fiber consumed. A large study done by the Harvard Medical School showed that it was not so much the fiber that helped to prevent colon cancer. Further large scale studies were done and it was shown that a diet high in vegetables, fruits, and whole grains was what was responsible for a reduction in colon cancer rates. This type of diet will also help detoxify your system from carcinogenic substances in general and from other toxins as the soluble fiber inside the gut will attach to it and go down the toilet instead of being reabsorbed in the colon into your system causing cancer.

Skin detoxification

The skin is the largest body organ with a lot of skin surface where skin pores can help detoxify under the right circumstances. This can be achieved with infrared saunas, with exercise that leads to production of sweat and by soaking in Epsom salt baths. Traditionally this has been done for centuries in the European spas, originally described by Sebastian Kneipp. The medical establishment in Europe (France, England, Germany, Austria), unlike American physicians, embraced the concept of natural therapies under the term “balneology”, at least for a number of decades. But  overuse by patients (abusing the system), badmouthing the relatively weak effect of detoxifying by Big Pharma and lack of funds from the health insurance companies put a damper on his movement. Part of this approach was the use of skin detoxification with healing baths (using Epsom salt and other salts) and physical exercise to the point of sweating. In addition “Waechselbaeder” according to Sebastian Kneipp (alternating hot and cold baths) were also used to stimulate the circulation and the immune system. The major component of Epsom salt is magnesium sulfate, which can be absorbed through the skin to a certain degree. So, some of the healing effect of Epsom salt baths may have come from an indirect balancing of low blood magnesium and the normalization of many metabolic processes that require magnesium as co-factors. Here is another, more vernacular description of Epsom salt use. Some of the assumptions such as improvement of diabetes, improvement of digestive absorption or relief from migraine headaches may be a combination of exaggeration and placebo effect rather than reality.

Kidney detoxification

The kidneys along with the liver are the major, natural detoxification organs of the body. However, they need enough fluids to dissolve water-soluble toxins and eliminate them from the body through the urine. Clean water should be consumed intermittently during the day (reverse osmosis water in glass bottles or BPA free bottled water). Because alcohol is a cell poison damaging the vital organs like the brain, heart, liver and kidneys it is best to minimize any alcohol intake to the absolute minimum (best to avoid alcohol altogether). The main filtration devices in the kidneys are the glomeruli, little packages of convoluted capillaries, which filter the blood several times per day. High salt intake, too much sugar and too much starch interfere with normal function of the glomeruli. Insulin resistance as is the case with metabolic syndrome and diabetes (often associated with obesity) will damage the filtration devices of the kidneys and cause toxin accumulation. To prevent damage of the kidney capillaries you need a healthy, basic diet like the Zone diet, South Beach diet or the Mediterranean diet as mentioned in this link.

This will keep fat deposits out of your arteries and the capillaries of the glomeruli of your kidneys, so the filtration process continues to work until a ripe old age. Your doctor can order tests (creatinine clearance) to assess whether the filtration capacity of your kidneys is normal.

Many toxins are fat-soluble and are stored in the fatty tissues. When you lose weight, you will need to drink more fluids to get rid of the water-soluble toxins through the kidneys and use coffee enemas to rid yourself of fat-soluble toxins (through bile and bowel movements).

There are a lot of websites that want to sell you herbs that should cleanse your system. They have a marginal effect, but I would stress that you want to adopt one of the diets mentioned above first to start with a healthy baseline. Such herbs as Buchu (Agathosma Betulina), Burdock, Echinacea and Yellow Dock Root (Rumex Crispus) are supposed to help the kidneys to detoxify. I am not certain whether there is medical proof for this.

Conclusion

Detoxification starts with adopting healthy food and lifestyle habits first. A low carb, low fat type diet as indicated (zone diet, a Mediterranean diet or South Beach diet) will be the footing from which the other detoxification methods will work. Some of the toxins will leave you when you work out and sweat. More will leave you when you enjoy an Epsom salt bath. This will give you some extra magnesium, which in turn will help to detoxify your system through several biochemical reactions where magnesium is a co-factor. Colonics or enemas will help remove toxins through your colon and they are more effective when coffee enemas are used (stimulation of your liver through the splanchnic nerves).

Infrared saunas can help to mobilize toxins and detoxify them through your skin. Take ample amounts of fluids as this will help remove some toxins through the kidneys and the urinary system. If major heavy metal poisoning were detected, the traditional intravenous chelation treatments described at the beginning of this blog would be more recommendable. A naturopathic physician or A4M physician (anti-aging physician) could advice you what is best in your case. Overall the thought is that by removing toxins the mitochondria in our cells, particularly in the brain, heart, liver, and kidneys can work more effectively giving you more energy and preventing the major diseases like cancer, cardiovascular disease (heart attacks and strokes), diabetes, arthritis and loss of cognitive function (Alzheimer’s disease and dementia).

More information about:

1. Chelation therapy: https://www.askdrray.com/tact-study-proves-effectiveness-of-chelation/

2. Vitamins, minerals and detoxification: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/vitamins-minerals-supplements/

Last edited Nov. 7, 2014

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Mar
04
2013

Coffee, Tea, Vitamin C And E Prevent Stroke And Dementia

Several studies showed that coffee, tea, vitamin C and E prevent stroke and dementia. Elizabeth E. Devore, ScD, now with Brigham and Women’s and Harvard Medical School, did a long-term study involving 5,395 people aged 55 and older who were part of the long-term Rotterdam Study of medical conditions and other factors in older adults. Over the 14-year observation period 601 patients developed strokes and 599 patients developed dementia. Detailed dietary questionnaires were available from the study that helped the author to detect what the protective factors were in those who did not develop strokes or dementia. When all other factors were excluded (including tea and coffee consumption) and only anti-oxidant factors were looked at, it turned out that there was no difference in terms of stroke or dementia rates when the lowest and highest percentiles of antioxidant groups were compared. But when the lowest and highest percentiles of tea and coffee consumers were analyzed and compared, about 90% of strokes and of dementia disappeared meaning that tea and coffee consumption is protective for both.  Dr. Devore explained that other studies have shown that vitamin C helps prevent strokes and vitamin E helps to prevent dementia and that both vegetables and fruit as well as tea and coffee have been shown in other studies to help reduce both.

Here is another article that investigated the role that vitamin E plays in reducing brain aging and preventing dementia and Alzheimer’s.

In a meta analysis vitamin C was shown to help prevent hemorrhagic and embolic strokes.

Coffee, Tea, Vitamin C And E Prevent Stroke And Dementia

Coffee, Tea, Vitamin C And E Prevent Stroke And Dementia

Vitamin C and E are not the only beneficial vitamins for the brain. Vitamin D3 can help prevent thromboembolic strokes as the Honolulu study going on for 34 years showed.

What about coffee and tea? There is a 10-year study involving 32,600 women where 1 or two cups of coffee per day led to a 25-32% reduction of strokes compared to non-coffee or tea consuming controls.

Males also experience a reduction of thromboembolic strokes with tea or coffee consumption. There has been a Finnish study that consisted of 29,133 smokers (smoking 5 cigarettes a day) aged 50 to 69 who were stroke free when entering the study. It ended in 1993 and had lasted for at least 5 years. Drinking two cups of black tea or 8 cups of coffee reduced the stroke risk by 21 to 23%.

Fruit and vegetables contain a lot of vitamin B complex. As this link shows vitamin B can lower cysteine, a blood component that contributes to heart attacks and strokes.

So, what should you do to prevent strokes and dementia?

Stop smoking, if you do. Avoid alcohol and drugs as much as you can. Your brain cells have very sensitive mitochondria that give you energy, but they are very sensitive to toxins. Avoid brain injuries like concussions as they can accumulate and lead to dementia. Whatever you can do for your heart is good for stroke prevention such as weight loss (down to a body mass index of 22.0), exercise, and sensible food intake (complex carbs, cut out sugar, have lean meat, more chicken, turkey, lean pork, only occasional beef). Take multiple vitamins including B, C, D3, E and drink tea or coffee. Some health oriented people may not want to hear this latter point (tea, coffee), but the studies show it is brain and heart protective.

More information on dementia: http://nethealthbook.com/neurology-neurological-disease/alzheimers-dementia-and-delirium/dementia/

More links regarding the Elizabeth E. Devore, ScD study:

1) http://www.everydayhealth.com/stroke/how-antioxidants-really-protect-against-stroke-and-dementia-3194.aspx

2) http://www.webmd.com/healthy-aging/news/20130220/high-antioxidant-diet-may-not-prevent-stroke-dementia-study-finds

Here is a link to the National Stroke Association about stroke prevention: http://www.stroke.org/site/PageServer?pagename=prevent

Last updated Nov. 6, 2014

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Aug
01
2005

Comfort Foods Make PMS More Uncomfortable

Premenstrual depression, moodiness, insomnia, abdominal cramps and headaches are some of the symptoms that create havoc for up to 40 % of menstruating women. Premenstrual Syndrome (or PMS for short) does not just mean a” cranky” few days for the women who suffer from it, but a host of unpleasant effects. Many experience bloating and breast tenderness, and they find that their daily functioning at work and in personal relationships is impaired. Food cravings are part of the picture, and often the so-called “comfort foods” are high on the list like ice cream, chocolate, cookies, or cake. Unfortunately these are not helpful at all, whereas other foods can be beneficial. The American College of Obstetricians and Gynecologists has published recommendations already in 2000 in which a diet of complex carbohydrates was recommended and supplementation of calcium, magnesium and vitamin E. Small meals that are rich in complex carbohydrates and that also contain protein and fat are useful to keep blood sugar levels stable. Even though some women crave sugar, candy, baked goods and pop, the rapid fluctuations in blood sugar only contribute to moodiness and irritability. Caffeine can also contribute to irritability, but by the same token, quitting coffee or tea abruptly will make many feel worse. A gradual decrease would be the gentler approach.
Alcohol intake is an especially bad idea, as it is a depressant and does nothing to lift the mood. People who have bloating or edema should avoid sodium.
Trials have shown what works to control PMS. More than 400 women were enrolled in a study group and were given 1,200 mg of chewable calcium carbonate daily. Those taking the supplement benefited from a 48% decrease of symptom severity. Within the Nurses’ Health Study II researchers followed up on a group of 1,057 women who got PMS and another group of 1,968 women who did not during 1991 and 2005. Women who consumed 400 IU of vitamin D a day had a lower relative risk of developing PMS. Consumption of calcium and vitamin D were measured by a food questionnaire. Calcium consumption of about four daily servings of fortified orange juice, skim-or low-fat milk or low-fat yogurt was inversely related to PMS.

Comfort Foods Make PMS More Uncomfortable

Comfort Foods Make PMS More Uncomfortable

The lead author of the study was Dr. Elizabeth Bertone-Johnson PhD, from the department of public health at the University of Massachusetts in Amherst. Her colleagues agree that vitamin D and calcium is beneficial to women of all ages, since these nutrients also reduce the risk of osteoporosis. Trials of vitamin B6 in doses of up to 100 mg daily seemed to help, as reported already in 2003 in a review by American Family Physician.

For the patient it means that small, regular meals are a good idea. So are complex carbohydrates, low-glycemic fruit like apples or berries and lots of vegetables. Consume low-fat milk or low-fat yogurt. Give the calcium supplements and the vitamin B6 a try. Minimize red meat, saturated and trans fats. Avoid salt, refined carbs, sugar, salt and alcohol. All of these aspects can make a significant contribution to a reduction of PMS symptoms as well as to health and wellness.

More info on premenstrual syndrome: http://nethealthbook.com/womens-health-gynecology-and-obstetrics/pms/

Reference: The Medical Post, June 28.2005, page 23

Last edited October 29, 2014

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