Aug
15
2020

Vitamin D Helps Combat the Covid-19 Coronavirus

An article in the Lancet describes that vitamin D helps combat the Covid-19 coronavirus. A publication in the Lancet (diabetes and endocrinology) on Aug. 3, 2020 reviewed randomized controlled trials between 2007 and 2020. The authors of the study wanted to see whether vitamin D had curative effects on Covid-19 coronavirus infections. Indeed, Dr. Adrian R Martineau and Dr. Nita G Forouhi pointed out that researchers examined vitamin D already in the 1930’s. In other words, at that time they showed that supplementation with cod liver oil prevented absenteeism in various industries. Notably, the active ingredient in cod liver oil was later found to be vitamin D. Vitamin D stimulates the immune system to overcome flu infections.

How Vitamin D overcomes Covid-19

The meta-analysis by Dr. Adrian R Martineau and Dr. Nita G Forouhi showed that vitamin D has several effects on Covid-19. In the early stages vitamin D stimulates host responses of the immune system against SARS-CoV-2 (= Covid-19 coronavirus). This involves the release of antimicrobial peptides, which have powerful antiviral effects making it more difficult for the virus to attack. Other publications showed that vitamin D stimulates autophagy, the process of “self-eating”. Cells that have been damaged by the virus or due to older age are removed by phagocytizing cells (monocytes, macrophages). This allows for new cells to take the place of the damaged cells.

Symptoms of Covid-19 are similar to the symptoms associated with vitamin D deficiency. Certain population groups are at a bigger risk, including older persons, obese individuals and persons Black ethnic or Asian ethnic background.  Several studies showed that supplementation with vitamin D3 became protective, preventative and therapeutic against Covid-19.

Vitamin D has specific effects

There are three major effects that vitamin D has.

  1. A strengthening of the epithelial barrier not allowing the coronavirus to penetrate into the lung tissue as easily.
  2. Release of defensins and cathelicidin, two crucial antiviral polypeptides that eradicate any virus in the system.
  3. Interruption of the “cytokine storm”, which is responsible for viral pneumonia to develop. Without the cytokine storm there is no damage to the lungs and people do not need treatment in the ICU. This is particularly important for people above the age of 60 and for people with pre-existing diseases.
  4. With the stabilizing effect of vitamin D regarding the immune function more severe forms of Covid-19 can turn into less severe forms with a better outcome.

Severe Covid-19 cases and vitamin D blood levels

There were two studies that have indicated that low vitamin D blood levels have a strong association with severe cases of Covid-19.  Extremely low vitamin D blood levels were found in severe Covid-19 cases in Spain, Italy and Switzerland. .

The authors concluded that any case of Covid-19 should receive adequate vitamin D3, but it is particularly important to the severe cases.

Two facts evolved from these studies: first, with low vitamin D blood levels there is a greater susceptibility to get Covid-19. Secondly, Covid-19 severity increases when the patient has low vitamin D blood levels.

What levels of vitamin D in the blood are required to fight Covid-19 coronavirus?

Vitamin D is very important for the integrity of the immune system. With  vitamin D blood levels below 15 to 20 ng/mL (37.5–50 nmol/L) there is a paralysis of the  immune system. Any viral or bacterial infection tends to overwhelm the body. This is the reason why the mortality due to Covid-19 coronavirus is highest in patients with these low vitamin D blood levels. People with secondary illnesses (diabetes, arthritis, autoimmune diseases, cancer) and patients above the age of 60 are at the highest risk. They have the lowest vitamin D blood levels and have the highest mortality rates. This publication describes this in more detail: Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths.

Above a vitamin D blood level of 30 ng/mL (=75 nmol/L) a patient’s immune system is functioning normally. However, the immune system is strongest at a vitamin D blood level of 50–80 ng/mL (125–200 nmol/L), which is the upper range of the normal level for vitamin D in the blood.

Keep in mind that vitamin D toxicity occurs only above 150 ng/mL (375 nmol/L). There is a wide margin of safety between 80 ng/mL (200 nmol/L, which is the upper range of normal) and the toxic level, which is 150 ng/mL (375 nmol/L). In any case it is important to have a blood test which gives information about the vitamin D3 blood level.

Vitamin D Helps Combat the Covid-19 Coronavirus

Vitamin D Helps Combat the Covid-19 Coronavirus

Conclusion

A new publication in the Lancet (diabetes and endocrinology) performed a meta-analysis of randomized controlled trials between 2007 and 2020. The authors found that a low blood level of vitamin D predicts that these patients are in trouble. They will have a severe form of Covid-19 when they get exposed to the coronavirus, SARS-CoV-2. Patients with higher normal vitamin D blood levels (50–80 ng/mL or 125–200 nmol/L) get very few symptoms of Covid-19 and have a low mortality. The reason is that their immune system is strong and they wall off the coronavirus at the epithelial barriers. Their immune system also releases polypeptides that eradicate the virus in the system. In addition, the “cytokine storm”, which is responsible for viral pneumonia is interrupted by vitamin D. Without the cytokine storm there is no damage to the lungs and people do not need treatment in the ICU.

Supplementation with vitamin D3 is safe

It is safe to supplement with vitamin D3 to bring the blood level into the upper range of normal. This keeps the immune system at its optimal functional level. There is a wide margin of safety between 80 ng/mL (=200 nmol/L, which is the upper range of normal) and the toxic level, which is 150 ng/mL (375 nmol/L).

Part of the text was published here before.

 

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Jul
25
2020

The Immune System Changes With Age

When we are young, we do not think about our immune system, but the immune system changes with age. When we are older than age 60, we notice that we may be taking longer to recover from a flu.

How does the immune system work?

There are two parts to the immune system, the innate immune system and the adaptive immune system. The innate immune system works to protect us from bacteria, viruses, toxins and fungi from the time we are born. The adaptive immune system uses B lymphocytes from the bone marrow to produce antibodies against viruses. This provides often lifelong immunity against this specific virus, but takes 3 to 5 days to kick in. Vaccinations can also trigger antibody production to protect us from viruses in the future. Both the adaptive and the innate immune system work together closely.

What are the ingredients for a fully functioning immune system?

The immune system consists of various immune organs that are distributed throughout the body. The bone marrow produces lymphocytes, granulocytes, macrophages, eosinophils and basophils. The adenoids in the back of the nasal passages and the tonsils in the back of the throat contain a lot of lymphocytes that are ready to protect us from colds and flus. We have lymph nodes throughout the body and they are connected with lymphatic vessels. The lymph nodes filter the lymph fluid that travels in the lymphatic vessels.

Other sites of lymphocyte production

The small intestine contains the Peyer’s patches, a collection of lymphocytes that protect our gut from invading bacteria or viruses. The spleen is located in the left abdominal cavity under the diaphragm. It removes old red blood cells and provides lymphocytes for the immune system. The thymus gland is located between the breast bone and the trachea. It changes bone marrow derived lymphocytes (B cells) into T lymphocytes that can process antigens from viruses and pass them on to the adaptive immune system for a full antibody response.

Cellular interactions between various players of the immune system

Back in the 1970’s it was already known that there were bone marrow derived B lymphocytes and thymus processed T lymphocytes. We knew then that B cells were involved in antibody production (adaptive immunity). T lymphocytes were thought to turn into killer T lymphocytes to kill cancer cells. But some T cells were T helper cells to process antigen and present it to B lymphocytes for antibody production.

More research since then refined what we know about the cells of the immune system.

Natural killer cells (NK cells)

Natural killer cells (NK cells) are part of the innate immune system. They attack cancer cells and cells that are infected by viruses. It takes about 3 days for their full action to develop. NK cells utilize the cell surface histocompatibility complex to decide whether to destroy a cell or not. T cell lymphocytes do not have the ability to do that. In the Covid-19 coronavirus situation NK cells play an important role to combat the disease right away.

Monocytes

They are large white blood cells that can differentiate further into macrophages and dendritic cells. Monocytes are part of the innate immunity, but they have an antigen presenting capability, which makes them also part of the adaptive immunity.

Memory T cells

The immune system learns to adapt to viruses and bacteria that we have come in contact with. The reason for the memory of the immune cells are the memory T cells. They replicate like stem cells, which keeps a clone of T lymphocytes, T helper cells and cytotoxic T killer cells in the background. They circulate through the body including the lymph glands and the spleen.

Immunosenescence as we age

There are several factors that come together, which age our immune system. The term for this is “immunosenescence“. There are genetic differences and differences due to the sex hormones. Estrogens increase the response of the immune system. In contrast, progesterone and androgens (including testosterone) decrease the immune response. This may be the reason why women tend to live longer than men.

As we age there are more and more memory T cells (both cytotoxic T cells and T helper cells). This weakens the formation of the natural killer cells (NK cells) of the innate immune system. Even the initiation of the adaptive immune system can be slower when we age and also the response to the flu vaccine. In addition, this can pave the way to autoimmune diseases.

The immune system changes with age: Evidence of immunosenescence

The following 3 factors show whether a person has immunosenescence:

  • The immune system has difficulties to respond to new viruses/bacteria or to vaccines
  • Accumulation of memory T cells crowding out cells of the rest of the immune system
  • Low-grade inflammation that is chronic and persists (“inflamm-aging”)

The process of immunosenescence starts with the involution of the thymus gland around the time of puberty. At that time the sex hormone secretion is highest. At the same time a growth factor from the bone marrow and the thymus gland decreases. It has the name interleukin-7 (IL-7). The end result is a slow decrease of the innate immune system with age and a more substantial weakening of the adaptive immune system due to a lack of naïve T and B cells. 

Chronic viruses can weaken the immune system further

The varicella herpes zoster virus causes chickenpox. In some people the chickenpox virus can persist, but the immune system actively keeps it controlled. In the 60’s or 70’s when the immune system is weakened from aging, there can be a flare-up as shingles, a localized form of the chickenpox virus.

Another virus, the human cytomegalovirus can cause a chronic infection that often persists lifelong. In this case the immune system is chronically weakened because of a massive accumulation of T memory cells, which keeps the human cytomegalovirus infection at bay.

What we need when the immune system changes with age 

Vitamin A

Both the innate and adaptive immunity depend on vitamin A and its metabolites. The skin cells and mucosal cells function as a barrier, which is important for the innate immunity. The skin/mucosal lining of the eye, the respiratory tract, the gastrointestinal and genitourinary tracts help the innate immunity to keep viruses and bacteria out of the body. Vitamin A is important to support macrophages, neutrophils and natural killer (NK) cells. In addition, vitamin A supports the adaptive immune system, namely T and B lymphocytes, so that the body can produce specific antibodies against viruses.

I do not take vitamin A supplements as I eat diversified foods like spinach, vegetables, poultry, Brussels sprout, fish and dairy products that contain vitamin A and carotenoids.

Vitamin C

This vitamin is a powerful antioxidant. It can neutralize reactive oxygen species, which are produced when the immune cells fight viruses and bacteria. Neutrophils, lymphocytes and phagocytes are all supported by vitamin C. Vitamin C and E co-operate in their antioxidant functions. Vitamin C is essential for a strong antibody response with bacterial or viral infections. I take 1000 mg of vitamin C once daily.

Vitamin D

The immune system is very dependent on vitamin D as the immune cells all contain vitamin D receptors. People who have less than 10 ng/mL of vitamin D in the blood are vitamin D deficient. They have much higher death rates when they get infected with the Covid-19 coronavirus.

Vitamin D regulates the expression of target genes. At the center is the vitamin D receptor, which is a nuclear transcription factor. Together with the retinoic X receptor (from vitamin A) the vitamin D receptor binds small sequences of DNA. They have the name “vitamin D response elements” and are capable of initiating a cascade of molecular interactions. The result is a modulation of specific genes. Researchers identified thousands of vitamin D response elements that regulate between 100 and 1250 genes.

You need enough vitamin D for your immune system

When enough vitamin D is present in the blood (more than 30 ng/mL) the immune system releases the peptides cathelicidins and defensins, which effectively destroy bacteria and viruses.

Vitamin D has mainly an inhibitory function regarding adaptive immunity. It inhibits antibody production from B cells and also dampens the effect of T cells. Researchers reported that vitamin D3 is useful in the treatment of autoimmune diseases.

I am a slow absorber of vitamin D3 as repeat blood vitamin D levels showed. I need 10,000 IU of vitamin D3 daily to get a blood level of 50-80 ng/mL (=125-200 nmol/L). This is the higher range of normal. Everybody is different. Ask your physician to check your blood level of vitamin D. Toxic vitamin D blood levels are only starting above 150 ng/mL (= 375 nmol/L).

Vitamin E

This is a vitamin that is fat soluble and helps the body to maintain its cell membranes. But researchers found that vitamin E also stimulates the T cell-mediated immune response. This is particularly important for the aging person to prevent respiratory tract infections. I take 125 mg of Annatto tocotrienols per day (this is the most potent form of vitamin E).

Vitamin B6

This vitamin is important for antibody production by B cells. Vitamin B6 regulates the metabolism of amino acids, which in turn form proteins. Antibodies and cytokines require vitamin B6. The T helper immune cells that initiate an adaptive immune response depend on vitamin B6 as well. I take a multi B complex vitamin (Mega B 50) twice per day, so I supplement with a total of 100 mg of vitamin B6 daily.

Folate

Folic acid is a coenzyme for the metabolism of nucleic acids and amino acids. Studies in humans and animals have shown that folate deficiency leads to increased susceptibility to infections. People with folate deficiency develop a megaloblastic anemia with immune weakness that leads to chronic infections. With my B complex supplement I get 2 mg of folic acid daily.

Vitamin B12

Methylation pathways depend on vitamin B12 as a coenzyme. Vitamin B12 is also involved as a coenzyme in the production of energy from fats and proteins. In addition, hemoglobin synthesis depends on vitamin B12. Patients with vitamin B12 deficiency develop pernicious anemia. These patients also have a weak immune system due to natural killer cell activity suppression and because circulating lymphocyte numbers are significantly decreased.

Treatment with cyanocobalamin reverses the immune weakness rapidly and treats pernicious anemia at the same time. I take 50 micrograms twice per day as part of the Mega-B50 multivitamin tablet. But I also inject 1000 micrograms of vitamin B12 every 6 months subcutaneously to be sure it is absorbed into the body. In older age the intrinsic factor from the stomach lining, which is required for absorption of vitamin B12 in the small intestine, can be missing, leading to vitamin B12 deficiency despite swallowing supplements.

Minerals required for a good immune response

Researchers identified five minerals that are essential for a strong immune system. They are zinc, iron, selenium, copper and magnesium.

Zinc

Zinc is important for a normal function of the innate and adaptive immune system. As zinc cannot be stored in the body, taking regular zinc supplements (30 to 50 mg daily) is important. I take 50 mg of amino acid chelated zinc daily.

Iron

Iron is important for cell oxygen transport and storage, DNA synthesis and for mounting an effective immune response. In particular it is the T cell differentiation and proliferation where iron is needed. Iron deficient people get a lot of infections because the immune system is paralyzed. I eat one spinach salad or steamed spinach daily, which gives me enough iron supply per day.

Selenium

Selenium is a trace mineral that is important for a normal immune response and for cancer prevention. When selenium is missing, both the adaptive and innate immune system are suffering. In this case viruses are more virulent. With selenium supplementation cell-mediated immunity is improved and the immune response to viruses is more potent. I take 200 micrograms of selenium per day.

Copper

Deficiency in copper results in a very low neutrophil blood count and causes susceptibility to infections. Copper is a trace mineral that participates in several enzymatic reactions. It is important for the innate immune response to bacterial infections. A well-balanced Mediterranean diet contains enough copper, which is why I do not supplement with extra copper.

Magnesium

An important cofactor for vitamin D in the body is magnesium. Magnesium participates in many enzymatic reactions. Between vitamin D and magnesium, the immune system is strengthened. I take 150 mg of magnesium citrate twice per day. By the way, magnesium also helps us to get a restful sleep, if we take it at bedtime.

Other dietary factors that strengthen the immune system

Polyunsaturated omega-3 fatty acids are essential for the body and help to modulate the immune system. I take 1800 mg of omega-3 (EPA/DHA) twice per day. I also like to eat fish and seafood at least 3 times per week.

Probiotics benefit both the innate and the adaptive immune system. They strengthen the epithelial gut barrier, which is an important innate immune defence. Probiotics also lower the risk for Clostridium difficile gut infections. I take one probiotic every morning.

The Immune System Changes With Age

The Immune System Changes With Age

Conclusion

The immune system consists of different organs like the bone marrow, the spleen, lymph glands, Peyer’s patches in the gut, the thymus gland and more. There is the innate immune system, which responds immediately to a virus like the Covid-19 coronavirus. The adaptive immune response involves antibody production against, for instance, the measle virus or the mumps virus. With the aging process the immune system slows down (immunosenescence). This involves an accumulation of memory T cells and a depletion of natural killer cells (NK cells). This means that the innate immunity is getting weaker as we age and chronic inflammation occurs more often. This is the reason why people above the age of 65 get more severe symptoms from the Covid-19 coronavirus. They are also more affected by influenza-type illnesses.

Take supplements to strengthen the immune system

I reviewed the cofactors of a healthy immune system in some detail. It is important that you pay attention to these, particularly the vitamin D3 intake. With a strong immune system, we can survive viral infections better, including the current Covid-19 coronavirus. Future research will likely detect how to reactivate a sluggish immune system in older people. This way vaccination responses following flu injections will become more reliable in seniors.

Jun
20
2020

Chronic Inflammation Can Cause Many Diseases

We knew since the mid 1990’s that chronic inflammation can cause many diseases. Among these are cancer, hardening of the arteries (atherosclerosis), arthritis, dementia (Alzheimer’s disease), frailty and other degenerative disorders. LifeExtension reviewed this topic in 2019.

Older people often accumulate chronic inflammation, which associates with the aging process. Persistent pain is one of the symptoms that chronic inflammation can cause.

Doctors use tests like the C-reactive protein, hemoglobin A1C, homocysteine and the erythrocyte sedimentation rate to measure chronic inflammation.

When the doctor diagnoses chronic inflammation, it is important to find ways to inhibit it and finally resolve it. Curcumin, ginger and non-steroidal anti-inflammatories are examples of measures that help inhibit inflammation. But it is only lately that scientists have found specialized pro-resolving mediators (SPM) that help to resolve chronic inflammation. They are polyunsaturated fatty acids, which health food stores offer as supplements.

Specialized pro-resolving mediators (SPM)

Researchers isolated several pro-resolving mediators that are metabolites of omega-3 fatty acids. This link discusses an experiment where researchers obtained synovial fluid from arthritis patients who took omega-3 fatty acids. They compared this to synovial fluid from volunteers who also took omega-3 fatty acid supplements. Within 4 weeks there was a big difference for the arthritis patients with higher levels of E- and D-series SPMs in synovial fluid and plasma. Dr. Silverman reviewed the action of SPMs here. He points out that they can be taken as supplements and that they are safe, because they do not have any side effects. Conditions such as asthma, irritable bowel syndrome and various musculoskeletal conditions with chronic inflammation respond very well to SPM supplements. Omega-3 fatty acid supplements (EPA) metabolize into the E-series resolvins.  On the other hand, Krill oil with Docosahexaenoic acid (DHA) metabolizes into protectins, maresins and the D-series resolvins.

Three vital tasks of pro-resolving mediators

SPMs fulfill three vital tasks, called remove, restore and renew.  First, they activate macrophages, which remove dead cells and cellular debris as a result of chronic inflammation. Second, they restore the healthy balance of inflammatory compounds and anti-inflammatory substances. Third, SPMs help renew tissues that were damaged by chronic inflammation.

Some examples where SPM’s were helpful resolving inflammation in health conditions

  • Alzheimer’s disease patients had reduced SPMs in cerebrospinal fluid of living patients and in the hippocampus of corpses who had Alzheimer’s disease.
  • A research group showed that defective SPM resolution can be responsible for missing resolution of atheromatous plaques in arteries. This leads to more and more hardening of arteries until a heart attack or stroke occurs.
  • With obesity or metabolic syndrome insulin resistance develops. Researchers found that certain SPM’s are missing in obesity, which causes chronic inflammation. However, they also found that precursors of SPMs such as 17-hydroxydocosahexaenoic acid (17-HDHA) can serve as a novel treatment agent to treat obesity-related complications.

Newer studies about SPMs

  • 62 patients with knee osteoarthritis had the precursor of resolvins, 17-HDHA tested in the blood. Compared to controls with no arthritis the 17-HDHA level in the arthritis patients was low. When levels of 17-HDHA were high, there was no pain in osteoarthritis patients.
  • Chronic periodontitis is a chronic inflammatory condition in the mouth. In a rabbit model this condition was cured with resolvin E1 derived from omega-3 fatty acids.
  • Delayed wound healing is typical for type 2 diabetes. In a mouse model with diabetic mice researchers inflicted skin wounds on mice. Subsequently they showed that with resolvins mice wounds healed much faster than in control mice.
  • Chronic kidney failure, liver impairment, diabetes, obesity and coronary heart disease showed abnormalities in the SPM system in humans. Potentially they will be healed with the help of resolvins or their precursors, which includes the omega-3 fatty acids EPA and DHA.
Chronic Inflammation Can Cause Many Diseases

Chronic Inflammation Can Cause Many Diseases

Conclusion

New compounds have been detected that derive from the omega-3 fatty acids EPA and DHA. They have the name specialized pro-resolving mediators (SPM). Included are the resolvins D1 and D2, the resolvins E1, E2 and E3 as well as the precursors 18-hydroxyeicosapentaenoic acid (18-HEPE) and 17-hydroxydocosahexaenoic acid (17-HDHA). The function of these compounds is to stimulate macrophages to clean up areas of chronic inflammation and remove cell debris and injured cells that cannot survive. While anti-inflammatories like ginger and curcumin only tone down the inflammation, SPMs help to resolve chronic inflammation. Various chronic clinical conditions were identified as being due to chronic inflammation. Chronic kidney failure, liver impairment, diabetes, obesity and coronary heart disease showed abnormalities in the SPM system. We may soon see alternative approaches treating these conditions with specialized pro-resolving mediators.

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Jun
06
2020

Adequate Vitamin D Level Strengthens the Immune System

The Covid-19 coronavirus crisis is teaching us that an adequate vitamin D level strengthens the immune system.

When we age, our resistance to infections weakens, but this may be because our immune system needs more vitamin D3. I have reviewed the super powers of vitamin D3 before in 2014. In the past the thought was that the human body would need only 400 IU of vitamin D3 every day to cure rickets. And these were the daily vitamin D3 recommendations from medical authorities for several decades. Gradually it became known that for cancer prevention, infection prevention, cardiovascular illness prevention and for diabetes prevention much higher doses of vitamin D3 were necessary. As pointed out in the previous link, almost 50% of the world population is deficient in vitamin D. This is due to a lack of exposure to sunlight and due to inadequate supplementation with vitamin D3.

History of vitamin D

Dr. Adolf Windaus received the Nobel prize for chemistry in 1928. It was to acknowledge “… his studies on the constitution of the sterols and their connection with vitamins”. His work involved the metabolism of vitamin D and the precursors of vitamin D.

Rickets

As the above link shows, rachitic children were treated since the mid 1800’s with cod liver oil and since the early 1900’s also with ultraviolet light. But we know now that 400 IU of vitamin D3 per day is just enough to cure rachitic children, but it is not enough to strengthen the immune system to fight influenza viruses or the Covid-19 coronavirus. I will discuss further below what vitamin D blood levels are important to achieve a healthy state of the immune system.

Adequate vitamin D level strengthens the immune system

The immune system is very complicated and consists of many cell types that interact with each other and the rest of the body. It is important to recognize that the innate immune system immediately inactivates intruding viruses. But the vitamin D blood concentration has to be high enough. The acquired immunity consists of antibodies that are produced by B cells. The antibodies were produced during prior infections that you have survived and you are now immune to. However, other antibodies that circulate in your blood may have originated from vaccines you received in the past (whooping cough, measles, tetanus, diphtheria etc.). With the Covid-19 coronavirus it is the innate immunity that plays the biggest role until a vaccine will be found in the future.

Vitamin D is a hormone

This 2013 paper explains that vitamin D is a hormone that stimulates its own vitamin D receptor. This is a nuclear receptor that has close relations to the cell DNA and can stimulate more than 900 polypeptides. They are messenger molecules that are involved in a variety of physiological functions. One of the key functions is the immune system. This link explains that T cells that have vitamin D receptors can develop into cytotoxic T cells (also known as “killer T cells”). They are important in fighting cancer, but also parasites.

The key is that the hormone vitamin D can release more than 100 polypeptides that have the power to fight virus attacks including the Covid-19 coronavirus.

Three mechanisms how vitamin D works against the virus

The researchers outlined 3 mechanisms of how vitamin D works:

  • Maintaining tight epithelial junctions making it more difficult for the Covid-19 coronavirus to penetrate.
  • “Killing enveloped viruses through induction of cathelicidin and defensins.” These powerful antiviral polypeptides can kill viruses that have invaded the blood stream within 1 to 2 days.
  • “…And reducing production of proinflammatory cytokines by the innate immune system, thereby reducing the risk of a cytokine storm leading to pneumonia.” It is people who get the viral pneumonia that are at a high risk of death. By bringing the blood level up to the higher range of normal, between 50 and 80 ng/mL, patients that have encountered Covid-19 coronavirus are more likely to survive.

Two polypeptides, cathelicidin and defensins

Again, I like to emphasize that it is not vitamin D that has a direct effect on the virus. It is two polypeptides, cathelicidin and defensins, which are powerful antiviral polypeptides, that are released by vitamin D.

They can kill viruses that have invaded the blood stream and can eliminate the cytokine storm. This all happens very fast, within only 1 to 2 days. But you have to have an adequate vitamin blood level for this to occur (about 50-80 ng/mL).

Sources of vitamin D

First of all, vitamin D is readily absorbed from food. But there are not many foods that contain enough vitamin D for the immune system. The ones that contain vitamin D are as follows:

  • “Fatty fish, like tuna, mackerel, and salmon.
  • Foods fortified with vitamin D, like some dairy products, orange juice, soy milk, and cereals.
  • Beef liver.
  • Cheese
  • Egg yolks. “

Sun induced amount of vitamin D

Secondly, vitamin D can be synthesized in the skin from exposure to sunlight. But for this to happen all the necessary enzymes need to be present.  This link explains that many older people above the age of 65 have low vitamin D blood levels because of a lack of sun exposure and a lack of cutaneous synthesis because of enzyme issues.

Vitamin D supplements

The most reliable source of vitamin D are vitamin D3 supplements. When people supplement with the same dose of vitamin D3 there will be people who get higher vitamin D blood levels than others, as absorption in the gut is different for different people.  The ones who have relatively low vitamin D blood levels are often called “slow vitamin D absorbers”. But when the vitamin D3 dosage is increased even those people will reach the recommended high normal range (50-80 ng/mL).

Vitamin D blood level

The vitamin D blood test has the scientific name “25-hydroxy vitamin D level”. This is now the recognized gold standard for determining who is deficient or has normal levels with respect to vitamin D. The following 2013 publication has studied the vitamin D level of 1,470 healthy Swiss men and women, 60 years or older. Vitamin D levels were classified as severely deficient when the level was below 10 ng/mL. The vitamin D level was deficient between 10 and 20 ng/mL. The level was insufficient when between 21 and 29 ng/mL. A level above 30 ng/mL is normal.

8 % of the subjects were severely insufficient and 66% had insufficient vitamin D levels. Only 26.1% of the subjects had normal levels. Over 50% of healthy older Swiss (above the age of 70) had insufficient vitamin D levels.

Which vitamin D level is safe and which is not?

A peer-reviewed publication of the effects of vitamin D in health and disease contains 269 references.

What vitamin D level is optimal? This question was reviewed in this paper.

  • Below 15 ng/mL the immune system is paralyzed
  • With a level above 30 ng/mL the immune system is working
  • A level of 50-80 ng/mL has the immune system working optimally
  • Above 150 ng/mL toxic vitamin D levels start
  • With 300 ng/mL severe toxicity begins

Vitamin D toxicity

It is only with high levels of vitamin D (more than 150 ng/mL) that you have to worry about high calcium levels in the blood or kidney stones (toxic levels). But the key is to not exceed 80 ng/mL regarding the vitamin D blood level. This gives you a lot of flexibility before you reach toxic levels (above 150 ng/mL). For those who want more information, here is a thorough, peer reviewed publication about vitamin D toxicity with 59 references.

Vitamin D supplement compliance

The question is why not more people take adequate vitamin D3 supplements.  We know that vitamin D can prevent so many chronic diseases including serious viral infections. The answer is complex, but it includes a fear of the population of vitamin toxicity (kidney stone and high calcium levels). However, as pointed out before, this occurs only above a vitamin D level of 150 ng/mL. With proper vitamin D blood level monitoring you never reach toxic levels of vitamin D.

Denial

Denial likely is another major factor. People feel that if they have a balanced diet, they would be protected from vitamin D insufficiency. As pointed out before this is a grave error to think as our food does not contain sufficient vitamin D to strengthen our immune system.

False security with low doses of vitamin D

Finally, there are people who think that low doses of vitamin D, like 1000 IU of vitamin D daily, would be enough. But it is not enough. This is why testing vitamin D blood levels is so important. It is a reality check. The blood level must be in the high normal range (50-80 ng/mL). At this level the immune system functions optimally.

Compliance issues

In this context there was an interesting study done by LifeExtension, a company that publishes monthly health magazines. In this study the company examined the vitamin D blood levels of LifeExtension members. They are the ones who should be knowledgeable in how important it is to have good, preventative vitamin D blood levels. The study showed that 38% of the vitamin D test results were less than 30 ng/mL. In addition, 69% of the vitamin D tests were less than 40 ng/mL. Finally, 85% of the vitamin D test results were less than 50 ng/mL. What this means is that LifeExtension members were non-compliant when it came to taking regular adequate vitamin D3 doses. This resulted in levels that were too low for the majority to protect them from the Covid-19 coronavirus.

Covid-19 coronavirus infections and vitamin D blood level

There is a tight relationship between vitamin D blood levels and the strength of the immune system. Essentially, coronavirus mortality measures who is vitamin D deficient. Without enough vitamin D on board the virus penetrates into the blood stream and penetrates the lining of the respiratory tract. Next the cytokine storm develops, which leads to viral pneumonia. Higher doses of vitamin D3 will mitigate the course of Covid-19 coronavirus.

Adequate Vitamin D Level Strengthens the Immune System

Adequate Vitamin D Level Strengthens the Immune System

Conclusion

The Covid-19 coronavirus pandemic has taught us how important an intact immune system is to survive the virus when you get it. We do know for some time how closely related a good vitamin D level is with the functioning of the immune system. I have reviewed here what a desirable vitamin D level is and how we can achieve this with oral vitamin D3 supplements. The goal is to achieve a vitamin D level in the upper range of normal (50-80 ng/mL). With a level like this the virus cannot penetrate the mucous membranes of the respiratory tract and even if it did, it cannot produce a cytokine storm in the blood that would lead to the deadly viral pneumonia or to blood clots. When the virus invades the bloodstream, vitamin D releases powerful antiviral polypeptides that can kill viruses within 1 to 2 days.

Literature

Here are some peer-reviewed publications on vitamin D:

 

May
09
2020

Vitamin D Is the Definitive Link

Vitamin D deficiency caused rickets in the past, but now we know that vitamin D is the definitive link for other health problems. The lack of it is the reason for numerous illnesses. A search in my website gives you more than 170 blogs where I am discussing the effect of vitamin D. These describe how vitamin D is the definitive link in a lot of different diseases. In a 2015 study from Brazil the authors noted that a critical vitamin D blood level was 12 ng/mL. All these critically ill patients received treatment in an ICU setting. In vitamin D blood levels of 12 ng/mL the mortality rate was 32.2%. A control group of ICU patients with more than 12 ng/mL had a mortality rate of only 13.2%. The authors concluded that a low vitamin D level on ICU admission was an independent risk factor for mortality in this critically ill patient group.

A few diseases where low vitamin D is the definitive link for a poor outcome

In patients, who have arthritis, cardiovascular disease, breast cancer, diabetes, osteoporosis, influenza and others, the laboratory tests that shows their 25-hydroxy vitamin D level, are usually below 15 ng/mL. This link has 269 peer reviewed references.

2015 Italian study showed that microvascular complications in diabetes patients were high, if the vitamin D3 blood levels were low. If patients had high levels of vitamin D, there were no complications such as retinopathy or nephropathy. But if levels were below 20 ng/mL, damages were significant in the capillaries of the eyes and kidneys.

Multiple sclerosis

It has been known for some time that in the northern hemisphere MS is more common because of the lack of sunshine, which in turn leads to less vitamin D3 production in the skin. Multiple sclerosis (MS) is an autoimmune disease where immune cells attack the lining of nerves. Both nerve cells and immune cells have vitamin D receptors. It appears that vitamin D calms down immune cells and remission of an MS relapse is more likely.

Dr. Fitzgerald and colleagues published a study in JAMA Neurology in 2015. Results of this study showed marked differences between MS patients with high and low vitamin D levels.

Multiple sclerosis rates with high and low vitamin D levels

Patients with the highest vitamin D blood levels (more than 40 ng/mL) had the lowest rates of new MS lesions. Previous studies found that a low blood level of vitamin D (less than 25 ng/mL) had an association with a higher risk of developing MS. Dr. Fitzgerald’s study showed that a 20 ng/mL (50.0-nmol/L) increase in serum vitamin D levels associated with a 31% lower rate of new MS lesions. Patients with the highest vitamin D level of more than 40 ng/mL (100 nmol/L) had the lowest amount of new MRI lesions (47% less than the patients with the lowest vitamin D levels).

Dementia and Alzheimer’s disease

A 2014 study showed that patients with a low vitamin D level had a connection with a high risk of dementia and Alzheimer’s disease.

Specifically, the researchers found the following observations.

  • Vitamin D level of less than 10 ng/mL: 122% increased risk of Alzheimer’s
  • A vitamin D level of 10 to 20 ng/mL: 51% increased risk of Alzheimer’s

Vitamin D is the definitive link for the immune system

In a publication of 2006 Dr. John Cannell and co-workers have reviewed why influenza has seasonal outbreaks. They found that the innate immune system was very dependent on vitamin D. Those who did not get enough sunlight in the northern hemisphere during January, February, March and April have an average 25-hydroxy vitamin D level of only 15 to 17 ng/mL. In contrast, from July to September the same volunteers had vitamin D levels of 24 to 29 ng/mL. The authors stressed that this was the reason why spring flus in the late winter/early spring season are common, but disappear in summer.

Vitamin D requirements for immune system is 2000 IU or more per day

Vitamin D is essential for the functioning of the innate and adaptive immune system. They also are the reason why children are not as affected by influenza viruses as adults are. Dr. Cannell said: “The innate immunity of the aged declined over the last 20 years due to medical and governmental warnings to avoid the sun. While the young usually ignore such advice, the elderly often follow it”. Had the older patients taken higher doses of vitamin D3 every day, their immunity would have been as strong as the children’s immunity. The publication cites another paper that found that 2000 IU per day or more will strengthen the immune system. Note that this is a higher dose than  treating rickets. Treatment of rickets responds to only 400 IU of vitamin D3 per day.

Mechanism of action of vitamin D in infectious diseases like influenza or Covid-19 coronavirus

Here is evidence from US researchers that states that higher doses of vitamin D3 will mitigate the course of influenza and of Covid-19 coronavirus. The researchers outlined that vitamin D has 3 effects:

  1. Maintaining tight epithelial junctions making it more difficult for the Covid-19 coronavirus to penetrate them.
  2. “Killing enveloped viruses through induction of cathelicidin and defensins.” These powerful antiviral polypeptides can kill viruses that have invaded the bloodstream within 1 to 2 days.
  3. “…And reducing production of proinflammatory cytokines by the innate immune system, thereby reducing the risk of a cytokine storm leading to pneumonia.” People who get viral pneumonia are at a high risk of death. By bringing the vitamin D blood level up to the higher range of normal, between 50 and 80 ng/mL, patients that have encountered Covid-19 coronavirus are more likely to survive.

Criticism of high dose vitamin D treatment

A common criticism of treatment with higher doses of vitamin D is that people would develop high blood calcium levels and would get kidney stones. Three recent studies have demystified this. A 2012 study looked at patients who were in the higher range of calcium levels, but deficient in vitamin D. They were treated with vitamin D3 und closely supervised. The calcium levels did not change after 1 year of high doses of vitamin D.

This 2018 study observed that there is a small amount of kidney stone formers who will form kidney stone with or without vitamin D3 treatment.  However, the large majority of patients do not form kidney stones with vitamin D treatment and their blood calcium levels stay the same before and after vitamin D treatment.

Toxic vitamin D blood levels

Toxic levels of vitamin D blood levels are above150 ng/mL, or 375 nmol/L. The therapeutic levels discussed here are well below these toxic levels.

Placebo controlled New Zealand study fails to show kidney stones

A placebo-controlled study from New Zealand went on for 3.3 years. 100,000 IU of vitamin D3 monthly (3333 IU per day on average) in the experimental group were compared to a placebo group. There were no vitamin D induced kidney stones and also no changes in calcium levels.

In past studies regarding vitamin D toxicity were done. But with these investigations there were many confounding factors that led to false results.  The investigators at those times mistakenly thought that they were side-effects of vitamin D. Up to this day conventional medicine often warns of hypercalcemia and kidney stones with vitamin D treatment. While the patient is on higher vitamin D levels, the physician can do blood and urine tests to see whether or not there is any concern.

Polypeptides released by vitamin D

There are more than 100 polypeptide hormones that are controlled by vitamin D. The most important ones for control of bacterial and viral infections are the defensin family and the cathelicidin family of polypeptides. They are instrumental in preventing the cytokine storm with a Covid-19 coronavirus infection treated with high vitamin D doses.

Decades after the original description of vitamin D researchers found out that vitamin D actually is a hormone.

There are vitamin D hormone receptors on almost every cell of the body. Vitamin D integrates the body cells and they respond as one unit. It is only recently that researchers found out about the release of polypeptides, particularly defensin and cathelicidin. They are  vital in the defence against the Covid-19 Coronavirus and the various flu types.

Vitamin D Is the Definitive Link

Vitamin D Is the Definitive Link

Conclusion

The detection of vitamin D originally occurred when rickets was examined. But later researchers found that vitamin D has hormone qualities.

You can prevent several diseases, like arthritis, cardiovascular disease, breast cancer, diabetes, osteoporosis and influenza. But you must take adequate amounts of vitamin D to bring the vitamin D blood level up. 25-hydroxy vitamin D blood levels are now recognized as the standard test to measure whether you have enough vitamin D on board. When it comes to fighting infections the vitamin D blood level has to be above 30 ng/mL (above 75 nmol/L). At this level the immune system will release defensin and cathelicidin polypeptides. These are powerful antiviral and antibacterial substances that can even fight Covid-19 coronavirus.

High vitamin D therapy is safe

With careful monitoring of blood vitamin D levels side effects of high vitamin D dosages were not found. Conventional medicine keeps on repeating old studies with confounding errors. This scares people, and as a result they don’t want to take enough vitamin D for prevention. Hypercalcemia and kidney stones were NOT found in randomized newer studies. As long as the vitamin D level does not exceed 50-80 ng/mL (or 125-200 nmol/L) vitamin D therapy is perfectly safe.

Apr
19
2020

What are Toxic Doses For Vitamins and Supplements?

We hear that vitamins and supplements are good for us, but what are toxic doses for vitamins and supplements?

I am going to review the common supplements of vitamin A, C, D3 and calcium. Most people have no problems sorting out the correct dose of other supplements. But these 4 are fairly contentious.

Vitamin A toxicity

Vitamin A comes in various precursors that are metabolized in the liver into the active form of vitamin A. The precursors are retinol, alpha-carotene, beta-carotene, and beta-cryptoxanthin. The FDA has suggested to label supplements with RDA’s (recommended daily allowance). This is in micrograms instead of the IU’s (International Units). 1 IU of vitamin A is 0.3 micrograms (mcg) of retinol. 1 IU of beta-carotene is 0.6 mcg beta-carotene.

Vitamin A is required for normal vision, reproduction, embryonic development, immune function and growth. The recommended daily allowance is 900 mcg (2700 IU) for men and 700 mcg (2100 IU) for women. The tolerable upper intake level for both sexes is 3000 mcg (9000 IU) of preformed vitamin A per day.

Recommended intake of vitamin A for children and adults

Recommended intake for children and adults is as follows.

  • Infants (0-6 months): 400 mcg (1200 IU) of vitamin A per day
  • Infants (7-12 months): 500 mcg (1500 IU) of vitamin A per day
  • Children 1-3 years: 300 mcg (900 IU) of vitamin A per day
  • Children 4-8 years: 400 mcg (1200 IU) per day
  • Boys and girls age 9-13: 600 mcg (1800 IU) of vitamin A per day
  • Boys age 14-18: 900 mcg (2700 IU) of vitamin A per day
  • Girls age 14-18: 700 mcg (2100 IU) of vitamin A per day
  • Men age 19 to above 70: 900 mcg (2700 IU) of vitamin A per day
  • Women age 19 to above 70: 700 mcg (2100 IU) of vitamin A per day

Symptoms of vitamin A toxicity

With too much vitamin A on board the symptoms are nausea, blurred vision, dizziness (vertigo), headaches, vomiting and lack of  muscular coordination. These symptoms are from transient effects of short-term or single large doses of vitamin A of 150,000 mcg (450,000 IU) per day. Chronic toxicity occurs when 30,000 mcg (90,000 IU) of vitamin A is ingested daily for months and years. This is more than 100-fold of the recommended daily allowance as you see from the table above. These overdoses lead to bone mineral loss in animals and humans. They also cause various cancers as described in the link above.

Evidence of toxicity from vitamin A

High doses like this are causing birth defects in the fetus of pregnant women. High vitamin A doses also cause liver fibrosis, liver cirrhosis and death. The liver is the main organ where vitamin A is metabolized and stored. It is no surprise that the liver is affected with overdoses of vitamin A. People with high alcohol intake, hyperlipidemia and pre-existing liver disease are particularly susceptible to vitamin A toxicity. Here is more information on vitamin A.

Vitamin C, what is a good supplement dose and what is an overdose?

Vitamin C was first found to be necessary to prevent scurvy in sailors. Eventually they took limes along, which contain vitamin C. A lack of vitamin C (scurvy) led to bleeding gums, painful arm and leg muscles, changes of hair growth and death from bleeding. Vitamin C supports the immune system, helps with the body’s chemical reactions to make tyrosine, carnitine, steroid hormones in the adrenal gland and neurotransmitters in the brain.

Daily recommended vitamin C allowances

Here are the recommended daily allowances (RDA) for vitamin C intake.

  • Infants 0-6 months: 40 mg daily
  • Infants 6-12 months: 50 mg daily
  • Children 1 to 13: between 15-45 mg daily
  • Boy teens age 14-18: 75 mg daily
  • Girl teens age 14-18: 65 mg daily
  • Adult men: 90 mg daily
  • Adult women: 75 mg daily
  • Pregnant women: 85 mg daily
  • Women who breast feed: 120 mg daily

Higher doses of vitamin C showed beneficial effects on the reduction of heart attacks. LifeExtension recommends a daily supplementation of vitamin C of 1000 mg to 6000 mg per day. Personally, I take 1000 mg of Esther vitamin C daily (Esther C is better absorbed than plain vitamin C). Vitamin C is eliminated from the body within 24 hours. This means that higher doses than the RDA listed above are easily handled by the body as there is no accumulation of vitamin C in the body.

Mega doses of vitamin C and adverse effects

Linus Pauling, a chemist who won the Nobel Prize in Chemistry in 1954, thought that higher doses of vitamin C would prolong life. He suggested daily doses of 2300 mg of vitamin C for maintaining good health. However, patients who have a Glucose-6-phosphate dehydrogenase deficiency can develop hemolytic anemia following intravenous vitamin C. With intermittent high dose vitamin C, often combined with glutathione for detoxification, oxalic acid is produced that shows up in the urine as hyperoxaluria. In time this can cause kidney stones with oxalic acid. Other symptoms with megadoses of vitamin C are diarrhea, reduced absorption of vitamin B12 and copper as well as iron overload. In addition, there can be acid erosions of the teeth with chewing of vitamin C tablets. Patients with kidney failure should not receive vitamin C mega doses.

Limit megadoses of vitamin C

The American Association of Poison Control Centers reported 0% deaths from vitamin C toxicity, but levels below 2000 mg per day are much safer in terms of possibly developing kidney stones. If you want to have intravenous glutathione and vitamin C infusions (typically 20,000 to 30,000 mg of vitamin C in one infusion) to detoxify you from mercury, keep the frequency of infusions at no more than once a month.

Vitamin D3 toxicity

Other publications have established that the original recommended dose of vitamin D3 by the Food and Nutrition Board of 2000 IU per day was way too low. According to this publication based on many other papers +/-10,000 IU per day should be considered the new recommendation. I have discussed the use of Mega vitamin D3 therapy for viral illnesses under this link before. Dr. Schwalfenberg stated: “This is a 1-time 50, 000 IU dose of vitamin D3 or 10, 000 IU 3 times daily for 2 to 3 days. The results are dramatic, with complete resolution of symptoms in 48 to 72 hours. One-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.”

The half-life of 25-hydroxy-vitamin D3 is 15.1 days. This means that the transient elevation of 25-hydroxy-vitamin D3 will last only 5 half-lives or 75.5 days. After that time (2 1/2 months) the elevation of vitamin D in the blood from the mega vitamin D3 dose, which was taken over 3 days, is eliminated.

Safety of vitamin D3

What is known about the safety of vitamin D3, particularly the higher vitamin D3 doses? First, it is wise to have your 25-hydroxy vitamin D blood levels taken from time to time. If any of these levels exceed 200 ng/ml it would be prudent to reduce the vitamin D dose or stop supplementation for a while. Otherwise it has been difficult to establish a toxic range. There are those who claim that 40,000 IU of vitamin D3 or more would lead to toxic levels of vitamin D3. With such vitamin D3 levels the blood calcium levels would show an increase and the physician can measure this as hypercalcemia. However, another study done in 2007 showed in MS patients that took 40,000 IU of vitamin D3 per day and that led to a blood level of 400 ng/ml of 25-hydroxy vitamin D did not lead to increased calcium levels and did not lead to hypercalciuria (too much calcium in the urine).

Do not exceed your upper 25-hydroxy vitamin D level 

But you should not exceed your vitamin D3 intake so that your 25-hydroxy vitamin D level exceeds 50-80 ng/ml. This is the ideal level for vitamin D3. Most patients have to take between 4000 IU of vitamin D3 and 6,000 IU of vitamin D3 to reach this blood level. There are slow absorbers of vitamin D3 who need 10,000 IU to achieve a 25-hydroxy vitamin D blood level of 50-80 ng/ml. (I am one of those.)

Evidence did not support toxicity for higher vitamin D3 doses

All of the papers that either indicated to the public that it would be unsafe or unnecessary to take vitamin D3 seem to have other agendas than communicating the truth. Had it been true that calcium leaked from the bones or the gut leaked calcium into the blood, calcifications of the bones or soft tissues, like the heart or kidneys, would have been evident. Also, kidney stones would have developed. However, a low calcium diet combined with corticosteroid drugs usually leads to a full recovery within a month. It is interesting to note that all of the dire predictions regarding toxic vitamin D3 levels did not materialize. Here is another website discussing vitamin D3 dosing.

Anecdotal report of 500,000 IU of vitamin D3 daily for 3 months

I talked to a conference participant (who has a fellowship degree of the A4M) at an Anti-Aging Conference about vitamin D3 toxicity. He told me that a compounding pharmacist made a mistake. His patient accidentally received a dosage of 500,000 Units of vitamin D3 per day for a full three months. Only then did he discover his mistake. The patient felt sluggish, but did not have any other symptoms. The patient stopped the vitamin D3 compound. He had an uneventful recovery with no detrimental effects. Researchers were not able to establish a toxic threshold for vitamin D3. It is needless to emphasize that we should never embark in experiments with “super dosages” of any supplement.

Calcium metabolism

There has been controversy about calcium supplementation. There is a fear of causing hardening of the arteries and a fear of causing kidney stones. Yet, with not enough calcium in the system you may develop osteoporosis.

Calcium levels in the blood are very stable because of a variety of mechanisms.

  • Vitamin D3 regulates the absorption of calcium from the gut.  Vitamin D3 together with vitamin K2 deposit calcium into the bone.
  • There is parathyroid hormone (PTH), which stimulates osteoclasts to release calcium from the bones.
  • The liver and kidneys metabolize calcitriol. It is a metabolic product of vitamin D3. Calcitriol increases the absorption of calcium in the kidneys and increases calcium and phosphorus from the gut. But calcitriol also increases the calcium and phosphorus release from the bones.
  • The parafollicular cells (also called C cells) in the thyroid gland produce calcitonin, another hormone.

Actions of Calcitonin

It counters the actions of the parathyroid hormone. Calcitonin inhibits the action of the osteoclasts thus lowering calcium, which stays in the bones. It also counters the resorption of calcium in the kidneys lowering calcium blood levels. PTH, calcitonin and calcitriol control the calcium level very tightly. This ensures that there is only a minimum of fluctuations of the blood calcium level. Apart from building bones and teeth calcium is important for a regular heartbeat, for blood clotting and for muscle contractions.

Calcium supplements

If you eat balanced meals, you may not need calcium supplements. Dairy products like milk, cheese and yogurt are high in calcium. Green vegetables, Tofu, beans, nuts and seeds also give you enough calcium.

If you don’t have balance in your diet, you may need more calcium intake as calcium supplements. But don’t exceed 1000 mg of calcium citrate or calcium carbonate per day. Calcium and magnesium have to always be balanced in the body. If you decide that you should supplement with calcium, you need to also supplement with magnesium citrate 150 mg twice a day to keep your minerals balanced.

Calcium toxicity

Antacids, hand lotions, mineral supplements and other vitamin and mineral supplements contain calcium. If you eat balanced meals with dairy products and vegetables, you may not need any calcium supplements. Symptoms of calcium overdoses are headaches, abdominal pain, bone pain, confusion, depression, diarrhea, irritability, irregular heart beat and more.

If you take the occasional antacid pills, do not supplement with calcium supplements, because you already consumed extra calcium inadvertently.

What are Toxic Doses For Vitamins and Supplements?

What are Toxic Doses For Vitamins and Supplements?

Conclusion

What are toxic doses for vitamins and supplements? Vitamins and supplements come in different versions. Vitamin A supplementation should not exceed 900 mcg (2700 IU) in men and 700 mcg (2100 IU) in women. But there is a fairly wide safety margin as only 30,000 mcg (90,000 IU) of vitamin A produce toxicity in both men and women.

The American Association of Poison Control Centers reported 0% deaths from vitamin C “toxicity”, but levels below 2000 mg per day are much safer in terms of preventing the  development of kidney stones.

With regard to vitamin D3 the recommended values of vitamin D3 for people is way too low. The 25-hydroxy vitamin D level should be in the 50-80 ng/ml range. Only when these values exceed 400 ng/ml is there cause for concern. Physicians found this level in people who consumed 40,000 IU of vitamin D3 daily. These doses did not lead to an increase in calcium levels and did not lead to hypercalciuria. But researchers consider them close to toxic levels.

Finally, calcium with normal balanced nutrition does not require calcium supplementation, particularly when a person consumes antacids. If a person eats a vegan diet, you may want to add 1000 mg of calcium carbonate or citrate and have your calcium level checked with a blood test.

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Apr
11
2020

Our Immune System Needs Vitamin D3

When we age, our resistance to infections weakens, but this may be because our immune system needs more vitamin D3. I have reviewed the super powers of vitamin D3 before in 2014. In the past it was thought that the human body would need only 400 IU of vitamin D3 every day to cure rickets. And this was the daily recommendation for vitamin D3 for several decades. Gradually it became known that for cancer prevention, infection prevention, cardiovascular illness prevention and for diabetes prevention much higher doses of vitamin D3 were needed. As this link points out, almost 50% of the world population is deficient in vitamin D. This is due to a lack of exposure to sunlight and due to inadequate supplementation with vitamin D3.

25-hydroxy vitamin D level

For several years now the 25-hydroxy vitamin D level in serum is accepted as the best tool to assess the vitamin D status of a person.  In the following you find data from this link.

Various 25-hydroxy vitamin D levels

Vitamin D deficiency (leading to rickets in infants or osteomalacia in adults): less than 12 ng/mL (less than 30 nmol/L)

 Inadequate vitamin D levels in healthy individuals (inadequate for bone or general health): 12 ng/mL to less than 20 ng/mL (30 to less than 50 nmol/L)

 Considered adequate for bone and overall health: 20 or more ng/mL (50 or more nmol/L)

 “Emerging evidence links potential adverse effects to such high levels”: >50 ng/mL(particularly >60 ng/mL); or >125 (particularly >150 nmol/L)

Vitamin D requirement in diseases other than rickets

We see from this that in terms of rickets there is a clear dose-response curve, where low vitamin D serum levels give a child rickets and higher levels prevent rickets. This is historically how vitamin D was detected as a vitamin. In the meantime, researchers have found vitamin receptors on many cells, so that endocrinologists consider vitamin D3 a hormone and signalling molecule.

The above link said that a vitamin D level of 20 to 50 ng/mL is normal. This link says that 20 and 40 ng/mL would be normal. But it adds that others recommend a level between 30 and 50 ng/mL.

Mortality of ICU patients is higher when vitamin D is low

A study from 2015 examined the mortality of 135 ICU patients. The researchers correlated Vitamin D blood levels with mortality rates of the patients. When vitamin D levels were below 12 ng/mL, there was a mortality rate of 32.2%. Patients with higher levels of vitamin D had a mortality rate of 13.2%. The authors concluded that low vitamin D blood levels were an independent risk factor for mortality. Patients less than 12 ng/ml had a 2.4-fold higher risk of dying than patients with normal vitamin D levels.

Stroke patients with low vitamin D worse off

Studies have shown that patients with the lowest level of vitamin D have the poorest functional outcomes following a stroke. When the vitamin D level was below 30 ng/mL the area of dead brain tissue was about two times larger than in those who had adequate vitamin D levels. Moreover, for every 10 ng/mL decrease in vitamin D levels the odds of a healthy recovery 3 months after the stroke fell by about half. This was independent of age and the initial stroke severity.

Seasonal vitamin D3 deficiency from January through April contributes to influenza

In a publication of 2006 Dr. John Cannell and co-workers have reviewed why influenza has seasonal outbreaks. They found that the innate immune system was very dependent on vitamin D3. Those who did not get enough sunlight in the northern hemisphere during January, February, March and April have an average 25-hydroxy vitamin D level of only 15 to 17 ng/mL. In contrast, from July to September the same volunteers had vitamin D levels of 24 to 29 ng/mL. The authors stressed that this was the reason why in the late winter/early spring flu seasons come and go every year while in summer they disappear.

Vitamin D requirements for immune system is 2000 IU or more per day

Vitamin D is essential for the functioning of the innate and adaptive immune system. They also had a reason why children are not as affected by influenza viruses as adults are: “The innate immunity of the aged declined over the last 20 years due to medical and governmental warnings to avoid the sun. While the young usually ignore such advice, the elderly often follow it”. Had the older patients taken higher doses of vitamin D3 every day their immunity would have been as strong as the children’s immunity. The publication cites another publication that found that 2000 IU per day or more will strengthen the immune system. Note that this is a higher dose than for rickets that responds to only 400 IU of vitamin D3.

Patients with many diseases lack vitamin D, but improve with vitamin D3

Many diseases showed an association with an underlying lack of vitamin D. When doctors examine patients’ blood who have arthritis, cardiovascular disease, breast cancer, diabetes, osteoporosis, influenza and others, their 25-hydroxy vitamin D level is usually below 15 ng/mL. This means that these patients have a very weak immune system. Vitamin D3 can restore their immune system and also restore more than 100 polypeptides that contribute to the healing process.

Here is evidence from US researchers that states that higher doses of vitamin D3 will mitigate the course of influenza and of Covid-19 coronavirus. The researchers outlined vitamin D has 3 effects:

  1. Maintaining tight epithelial junctions making it more difficult for the Covid-19 coronavirus to penetrate.
  2. “Killing enveloped viruses through induction of cathelicidin and defensins.” These powerful antiviral polypeptides can kill viruses that have invaded the blood stream within 1 to 2 days.
  3. “…And reducing production of proinflammatory cytokines by the innate immune system, thereby reducing the risk of a cytokine storm leading to pneumonia.” It is people who get the viral pneumonia that are at a high risk of being killed. By bringing the blood level up to the higher range of normal, between 50 and 80 ng/mL, patients that have encountered Covid-19 coronavirus are more likely to survive.

Higher doses of vitamin D3 for various diseases

Dr. Norman Shealy has summarized here what Dr. Joe Prendergast, an endocrinologist and diabetologist did for various patients. This link also contains many references regarding the use of high doses of vitamin D3.

During 30 years of clinical practice Dr. Prendergast treated some conditions where the vitamin D level was extremely low and where patients had a profound weakness of the immune system.

He treated these patients with 50,000 IU of vitamin D3 daily for various times. The diseases that responded to vitamin D3 therapy follow.

Conditions responding to vitamin D3 therapy

  • Reversal of advanced coronary disease
  • Reversal of advanced lung disease, avoiding a lung transplant!
  • Cure of multiple sclerosis
  • Cure of amyotrophic lateral sclerosis
  • Regression of rheumatoid arthritis
  • Improvement in allergies
  • Control of many cancers including prostate, breast, colon, brain tumors, leukemia, myeloma, etc.
  • Reversal of osteoporosis
  • Prevention of influenza
  • Cure of depression and many other mental disorders
  • Hashimoto’s hyperthyroidism

No toxicity with higher doses of vitamin D3

LinkedIn summarizes Dr. Prendergast’s career as follows:

“J. Joseph Prendergast has been a practicing physician for over 30 years. He is Board Certified in Internal Medicine as well as Endocrinology and Metabolism. A graduate of Wayne State University in Detroit, Michigan he completed a fellowship in Endocrinology and Metabolism at Henry Ford Hospital Detroit, MI and his residency at the University of California, San Francisco. Dr. Prendergast has published over 40 medical articles in well-known publications such as the Journal of the American Medical Association, The New England Journal of Medicine and Diabetes Care.”

Do not take calcium supplements when on higher doses of vitamin D3

Dr. Prendergast had no complications in patients with these high doses of vitamin D3, but he stressed that the patient is instructed not to take calcium supplements to prevent high calcium levels. He checks vitamin D blood levels and aims at levels of 80 to 150 ng/mL.

The dosage suggested on this audiotape is 50,000 IU per day for one week, then a maintenance dose of 50,000 IU once per week (=7143 IU per day). But it is also important to change your nutrition to a well-balanced diet. He stated that there is no toxicity with this treatment schedule as long as you do not take additional calcium supplements. On the other hand, dairy products are OK to take.

Our Immune System Needs Vitamin D3

Our Immune System Needs Vitamin D3

Conclusion

Many patients with diseases like osteoporosis, high blood pressure, cardiovascular disease, influenza, multiple sclerosis, allergies and other disease listed above have very low vitamin D blood levels. Vitamin D is necessary to produce more than 100 polypeptides. The body requires these for normal cell function. Rickets was first cured by supplements of only 400 IU of vitamin D3 per day. In the meantime, it is recognized that a vitamin D level of less than 15 ng/mL constitutes a vitamin D deficiency. To cure other diseases requires much higher vitamin D levels in the blood, in the order of 50 to 80 ng/mL.

Dr. Prendergast uses higher vitamin D levels with better results

Dr. Prendergast states that patients with pre-existing diseases have to take much higher levels of vitamin D3. This rebalances their metabolism and cell function. In time this will gradually cure their disease. He suggests 50,000 IU of vitamin D3 daily for 7 days. This is then followed by 50,000 IU per week (7143 IU per day) for maintenance. He said that this will lead to a vitamin D level of between 80 and 150 ng/mL. In 30 years of practice he has not seen a single case of vitamin D3 toxicity, provided the patient refrains from taking calcium supplements. This is the exact opposite of what the Mayo Clinic or Harvard University websites say. It also shows that there are always some pioneering forces in the generally ultra-conservative medical society.

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Mar
21
2020

Coping with Covid-19 Coronavirus

Recently the topic of coping with Covid-19 Coronavirus is at the forefront of our thinking. Coronaviruses are a group of viruses that lead to severe respiratory distress. The first known coronavirus appeared in 2003 and was called Severe Acute Respiratory Syndrome (SARS). It originated in China. The second one was called Middle East Respiratory Syndrome (MERS), which began in Saudi Arabia in 2012. Covid-19 Coronavirus started in December 2019 in Wuhan, China.

The Wuhan market in Wuhan, China

This link contains a walk-around in the Wuhan market, where’re all kinds of animal parts are sold for the peculiar taste of Chinese connoisseurs. Unfortunately, it may be the mix of infected animal parts and crowds of humans that can lead to endemics like SARS or Covid-19 Coronavirus.

Covid-19 Coronavirus is a variation of a general flu virus. Coronavirus attaches to the mucous membranes of the nasal cavity, the sinus cavities and the pharynx. It sets up an inflammatory reaction of the mucous membrane cells. The cold-like symptoms in the head occur around the 5th day of infection, but sometimes there is a longer incubation and the cold-like symptoms occur only around day 10. A high fever and a cough are next. Next it affects the mucous membranes of the voice box, the trachea, the bronchial tubes and finally of the alveoli (the tiny air sacs of the lungs).

Viral pneumonia causes mortality

It is this inflammation of the alveoli, which can make a person dangerously sick. If the virus is stronger than your immune system, you can get viral pneumonia. With this condition there are a lot of secretions that must be coughed up or else there is not enough surface in the lungs to absorb oxygen. You can literally drown in your own secretions. It is the inflammation in the lungs, called viral pneumonia, which kills many patients.

Antiviral medication

Regular antibiotics will not help for a viral flu, whether this is the influenza virus or the Covid-19 Coronavirus. But antiviral medication like oseltamivir (Tamiflu), zanamivir (Relenza), or peramivir (Rapivab) might help. Despite these efforts the death rate of the ordinary influenza virus infection is about 0.13 %, as the Centers for Disease Control have calculated. In comparison, SARS had a mortality rate of 7.5 to 10% and MERS a mortality rate of 35%. The present new variation of a coronavirus has a mortality around 3.7% in China and 1.9%, outside of China according to the WHO.

Interception of the multiplication of Covid-19 coronavirus

Why wait until the virus has traveled from the top (nose, sinuses) to the bottom (lungs)? There is a mega vitamin D3 dose therapy that became popular when the SARS epidemic was around. It was originally developed for influenza.

Recently I came down with a cold, when I remembered that you can fight the cold or flu with mega vitamin D3 doses. The cold did not fit into my plans. I was three days before singing as a lead singer in a local church and I needed my voice. I felt a burning in the back of my throat and knew I was coming down with a cold. Next I felt congested in my nose and sinuses.

Experience of the mega vitamin D3 therapy

I braced myself for the cold affecting my voice box and taking my voice away. But on the second day of the cold/flu I took 50,000 IU of vitamin D3. The following day the congestion was still confined to my nose and sinuses only. But it did not go further down into my throat or chest. I continued my dose of 50,000 vitamin D3 for the second day and a 3rd dose on the 3rd day. The mega vitamin D3 doses saved my voice. My cold/flu never progressed any further; it simply stopped.

Slow and fast absorbers of vitamin D3

I know that I am a slow absorber of vitamin D3 and normally need 10,000 IU daily to get into the normal range of 25-hydroxy vitamin D using a blood test. My cold symptoms settled down, there was no sign of laryngitis, where you sound scratchy. I also did not get a cough, which based on my past experience, would have lingered on for weeks. Other people who are fast absorbers get effective 25-hydroxy vitamin D blood levels with daily doses of only 4,000 IU or 5,000 IU. However, for the mega dose vitamin D3 therapy these subtle differences don’t matter. The whopping dose of vitamin D3 leads to a high 25-hydroxy vitamin D levels that last about 2 months.

Mechanism of stimulation of the immune system by mega vitamin D3 therapy

Taking high doses of vitamin D3 releases cathelicidin and defensins. These are polypeptides that have antibacterial and antiviral properties. The vitamin D antimicrobial pathway is described in this link. Vitamin D stimulates the immune system (B cells and T cells), which can suppress viral and bacterial infections. Dr. Thornburg describes that an adult should treat a cold/flu within 24 to 36 hours after onset with 50,000 IU of vitamin D3 once daily for 3 days. He also lists pediatric doses. A 30 lb child would receive 1/5th of the adult dose or 10,000 IU once a day for three days.

Following this treatment, the patient resumes the previous vitamin D3 maintenance dose.

Opinion of conventional medicine

The Mega vitamin D3 therapy approach is not part of conventional medicine. Here is a publication that states that Vitamin D, Vitamin C, Zinc, and Echinacea in combination can be useful in the treatment of the common cold. But the section that describes the use of vitamin D seems to be very conservative. It does not even mention the importance of measuring the vitamin D blood levels.

25-hydroxy vitamin D blood level

Without a 25-hydroxy vitamin D levels the physician cannot determine whether or not you have adequate vitamin D blood levels. The normal level is considered to be 25-80 ng/mL. Many physicians say a level of 50-80 ng/mL is better (higher end of normal). This blood test will measure the sum of vitamin D from oral vitamin D3 and from sun-induced vitamin D. This test also reveals whether a person is a fast or a slow absorber. What counts is that a person taking vitamin D3 gets the blood level into the therapeutic range.

Vitamin D Toxicity 

Are there toxic levels of vitamin D? Whenever the topic of mega dose vitamin D3 is mentioned, conventional medicine will warn that vitamin D toxicity could develop including kidney stones and “bone pain, drowsiness, continuous headaches, irregular heartbeat, loss of appetite, muscle and joint pains.” In these cases of toxicity the researchers did not indicate what the level of 25-hydroxy vitamin D level was. Other publications have established that the original recommended dose of vitamin D3 by the Food and Nutrition Board of 2000 IU per day was way too low.

According to this publication based on many other papers 10,000 IU per day or more should be considered the new recommendation.

Vitamin D3 Mega dose

Dr. Schwalfenberg stated: “This is a 1-time 50,000 IU dose of vitamin D3 or 10, 000 IU 3 times daily for 2 to 3 days. The results are dramatic, with complete resolution of symptoms in 48 to 72 hours. One-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.” The half-life of 25-hydroxy-vitamin D3 is 15.1 days. This means that the transient elevation of 25-hydroxy-vitamin D3 will last only 5 half-lives or 75.5 days. After that time (2 1/2 months) the body has eliminated the mega dose of vitamin D3.

Community-based measures to reduce spread of Covid-19

There are several measures that help to stop the spread of Codi-19 Coronavirus. As our hands are often transmitting flu bugs to our eyes or mouth, it is important to wash our hands frequently with soap and water. And do not touch your face!

Coughing, sneezing

Cough or sneeze into your bent elbow, not your hands or into a Kleenex.

Cleaning your home

Frequently clean toilet seats, light switches, door knobs and bedside tables. These are the items that are most frequently touched. Phones, computers and other devices should be wiped down with alcohol prep wipes (70% alcohol).

Social distancing

When Covid-19 Coronavirus is spreading in a community, it is important that people avoid large gatherings. This often includes school closures and closures of theatres, sports facilities etc. Droplets can fall up to 2 meters (6 ½ feet) from the mouth of an infected person. It makes sense that an infected person wears a mask to retain larger droplets with viruses, but the virus is small enough to directly penetrate a regular mask. The recommendation right now is that people who are self-isolating, but have no symptoms do not wear a mask. Masks are in short supply worldwide.

Self-quarantining

Many countries also recommend that all overseas travellers who come back home should voluntarily self-quarantine themselves for 14 days and watch for symptoms. The main two symptoms are a high fever and a persistent cough. Take your temperature once or twice daily when in self-quarantine. Make sure you have a friend bring you food items and whatever you need from a grocery store. If you are on regular medicine, talk to your pharmacist how this can be home delivered or picked up by a friend.

Vaccine development against Covid-19 Coronavirus

Vaccines against Covid-19 Coronavirus are still one year or more away from mass production. In April 2020 one of the vaccine manufacturer, Moderna will start testing on humans in the US. But it will take until next year before this vaccine will be available to everybody.

Another approach to help patients with Covid-19 Coronavirus infection is a plasma-derived hyperimmunoglobulin therapy.  Antibodies from patients who recently recovered from a Coronavirus infection are the basis for this treatment. Takeda, Japan’s largest drug manufacturer, announced on March 4, 2020 that it would develop a hyperimmunoglobulin against Covid-19 Coronavirus.  Recently recovered patients have specific antibodies in their blood, which the company can recover from their plasma. When physicians inject the recovery plasma into patients with a positive test against Covid-19 Coronavirus, their recovery accelerates and the course of the infection is much milder. This new therapy was dubbed “TAK-888”. However, testing requires still many more month of further research to ensure it is safe.

Why does Italy have high Corona death rates?

In the March 18, 2020 issue of the German Magazine stern.de this question was posed. There are 31,500 Italians with the Coronavirus infection so far. 2503 people died from the Covid-19 Coronavirus. This translates into a mortality rate of around 8%, which is more than double of average rate of in other countries. For comparison, here are the death rates in other countries: China 4%, South Korea 1% and Germany 0.26%. Why these tremendous differences?

Low testing rates

Scientists believe that the policy in Italy to only test patients with symptoms suppresses the number of reported infected patients. This leads to unreported cases and falsely reporting higher Corona death rates. In South Korea where mortality rates are low, physicians did 3692 tests for Covid-19 per a million people up to March 8, 2020. In contrast, health professionals in Italy did only 826 Corona tests per million people. This leads to underreporting of infected people, causes more transmissions and higher death rates. Dr. Jeffrey Shaman, an epidemiologist at Columbia University said: “If we have 3,500 confirmed cases in the U.S., you might be looking at 35,000 in reality”.

Physicians in the US do not test enough people for Covid-19, and like in Italy this will lead to much higher infection rates as assumed to occur in the beginning.

Seniors are at higher risk for mortality from Covid-19 Coronavirus

According a report from the UN in 2015 there were 28.6% of the Italian population were 60 years or older. In South Korea 18.5% of People were older than 60 at the same time. Seniors have other underlying diseases like type 2 diabetes, emphysema, heart disease and others. When patients with these conditions get Covid-19 Coronavirus, the mortality is higher. Children and people below the age of 60 may have clinically undetectable disease, and only a Covid-19 test would show it, if they were positive.

Coping with Covid-19 Coronavirus

Coping with Covid-19 Coronavirus

Conclusion

Vitamin D3 has long recognition as a stimulant of the immune system. We now know that high doses of vitamin D3 release two polypeptides, cathelicidin and defensins. They have antibacterial and antiviral actions. Several physicians have developed a mega vitamin D3 approach when a cold or flu just starts to hit you. An adult should then take 50,000 IU of vitamin D3 daily for 3 days. In many cases it will cut the cold/flu short within 48 to 72 hours. Dr. Schwalfenberg said that “one-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.”

Inflammation from Covid-19 Coronavirus

Any flu virus, including the coronavirus varieties, cause a lot of inflammation. When the inflammation reaches the lungs (inflammation of the air sacs or alveoli) a lot of patients die because they cannot get enough air. But with the use of mega vitamin D3 doses we have a powerful tool to prevent the further spread of the virus. If you take this on the first or second day of the flu, you can prevent the further spread of the coronavirus into the lungs. The reason is the release of cathelicidin and defensins from the action of vitamin D3. These polypeptides have antibacterial and antiviral properties.

Vaccine development

Vaccine development is still a year away from being available. In the meantime, high dose vitamin D3 therapy is available and is cheap.

Most importantly, help stop the spread by being meticulous about your hygiene, as mentioned before. Also, adjust your life style by staying away from larger crowds. You will not hang out in bars and clubs, and instead of going out for meals, prepare your own or arrange for food delivery. Panic never helped in crisis situations; common sense does!

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Dec
28
2019

Fight The Cold Or Flu With Mega Vitamin D3 Doses

Recently I came down with a cold, when I remembered that you can fight the cold or flu with mega vitamin D3 doses. The cold did not fit into my plans. I was three days before singing as a lead singer in a local church and I needed my voice. I felt a burning in the back of my throat and knew I was coming down with a cold. Next I felt congested in my nose and sinuses. I braced myself for the cold affecting my voice box and taking my voice away. But on the second day of the cold/flu I took 50,000 IU of vitamin D3. The following day the congestion was still confined to my nose and sinuses only. But it did not go any further down into my throat or chest.

Mega vitamin D3 doses saved my voice 

The following day was the church performance and everything went well. The Christmas songs created a festive atmosphere in the congregation. The psalm melody that my wife had composed was a welcome change from the normally stuffy psalm. And despite the feeling of an oncoming cold, my voice was still clear.

My cold did not progress

Since then I noticed some more mucous formation and I continued my dose of 50,000 vitamin D3 for a total of 3 doses. Through blood tests for vitamin D 3 levels I know that I am a slow absorber of vitamin D3 and normally need 10,000 IU daily to get into the normal range of 25-hydroxy vitamin D using a blood test. Now the cold symptoms settled down. There was nothing of the common laryngitis, where you sound scratchy. I also did not get a cough, which based on past experience, would have lingered on for weeks.

How vitamin D stimulates the immune system

Taking high doses of vitamin D3 releases cathelicidin and defensins.

These are polypeptides that have antibacterial and antiviral properties. The vitamin D antimicrobial pathway is described in detail here:

Vitamin D stimulates the immune system (B cells and T cells), which can suppress viral and bacterial infections. Here is another article that recommends the “vitamin D hammer” as the authors term the mega vitamin D3 therapy. Dr. Thornburg describes that an adult should treat a cold/flu within 24 to 36 hours after onset with 50,000 IU of vitamin D3 once daily for 3 days. He also lists pediatric doses. Following this treatment the patient resumes the previous vitamin D3 maintenance dose.

Opinion of conventional medicine

This approach is not conventional medicine. Here is a publication that states that Vitamin D, Vitamin C, Zinc, and Echinacea in combination can be useful in the treatment of the common cold.

But the section that describes the use of vitamin D seems to be very conservative. It does not even mention the importance of measuring the vitamin D blood levels. It is 25-hydroxy vitamin D which is what one needs to determine blood levels.

The normal level is considered to be 25-80 ng/mL. Many physicians say a level of 50-80 ng/mL is better. This blood test will measure the sum of vitamin D from oral vitamin D3 and from sun-induced vitamin D. This test also shows whether a person is a fast absorber or a slow absorber. What counts is that a person taking vitamin D3 gets the blood level into the therapeutic range.

Are there toxic levels of vitamin D?

Whenever the topic of mega dose vitamin D3 is mentioned, conventional medicine will warn that vitamin D toxicity could develop including kidney stones and “bone pain, drowsiness, continuous headaches, irregular heartbeat, loss of appetite, muscle and joint pain”.

In these cases of toxicity the researchers did not indicate what the level of 25-hydroxy vitamin D level was.

Other publications have established that the original recommended dose of vitamin D3 by the Food and Nutrition Board of 2000 IU per day was way too low. According to this publication based on many other papers 10,000 IU per day or more should be considered the new recommendation.

Dr. Schwalfenberg stated: “This is a 1-time 50, 000 IU dose of vitamin D3 or 10, 000 IU 3 times daily for 2 to 3 days. The results are dramatic, with complete resolution of symptoms in 48 to 72 hours. One-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.”

The half-life of 25-hydroxy-vitamin D3 is 15.1 days. This means that the transient elevation of 25-hydroxy-vitamin D3 will last only 5 half-lives or 75.5 days. After that time (2 1/2 months) the mega dose taken over 3 days is eliminated.

Fight The Cold Or Flu With Mega Vitamin D3 Doses

Fight The Cold Or Flu With Mega Vitamin D3 Doses

Conclusion

Vitamin D3 has long recognition as a stimulant of the immune system. We now know that high doses of vitamin D3 release two polypeptides, cathelicidin and defensins. They have antibacterial and antiviral actions. Several physicians have developed a mega vitamin D3 approach when a cold or flu just starts to hit you. An adult should then take 50,000 IU of vitamin D3 daily for 3 days. In many cases it will cut the cold/flu short within 48 to 72 hours. Dr. Schwalfenberg said that “one-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.”

Possible future clinical trial could verify effectiveness of mega vitamin D3

It would be desirable that the medical establishment conduct a clinical trial about the effectiveness of mega vitamin D3 use in colds/flus. Once the results are out, it would be loss of business for the pharmaceutical manufacturers.  Most of the cold-remedies would no longer be in high demand. For this reason it does not appear that it would be in the interest of Big Pharma or of organized medicine to organize such a clinical trial!

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Aug
03
2019

The Best Ways To Prevent Cancer

Cancer is the second leading cause of death, that’s why it is important to learn about the best ways to prevent cancer. Generally speaking you want to remove cancer-producing substances (carcinogens) from your diet. But diet is only part of your lifestyle that can contribute to cancer. I shall list some of the more important dietary factors below and briefly touch on important other factors.

Avoid burning your meat

When you use the BBQ, you should avoid burning your meat. Even though the marks of “charring” are considered desirable on meat from the grill, this is really burnt! As a matter of fact it is a lot better to use a slow cooker at low heat and simply cook your food longer. This way you don’t create carcinogens. Avoiding to burn your meat is particularly important for the red meats.

Sugar and an overabundance of starchy foods can cause cancer

You never thought that sugar and an overabundance of starchy foods could cause cancer, but they do. The reason is that the metabolism of cancer cells is using 10- to 12-times more sugar than the metabolism of normal cells. The worst thing a cancer patient can do is to over-consume sugar. Replace sugar by stevia, which is a harmless, plant-based sweetener and does not lead to an insulin reaction. Avoid all other sugar substitutes, as there are other heath problems with most of them.

Avoid phthalates

Those who have a craving for macaroni and cheese are out of luck. This food contains phthalates that are part of the ingredients of almost every sample of cheese powder used to manufacture macaroni and cheese. Phthalates can cause infertility and breast cancer. So you must definitely avoid macaroni and cheese, at least the stuff from the box. Prepare your own!

A high fat diet

What does a high fat diet do? It increases the risk for breast cancer. But it can also increase colorectal cancer risk. Limit your fat intake to about 10% of saturated fat. That is the recommendation of the FDA. Increase your consumption of fish and seafood. Only one proviso: predator fish like shark, marlin, tilefish, swordfish and grouper are high in mercury. But wild salmon, sardines and oysters are low in mercury. You can also enjoy shrimps and prawns.

Take high dose vitamin D3 supplements

High dose vitamin D3 supplements help you to avoid cancer. There are strong statistics showing that vitamin D3 is a powerful tool to lower your risk of developing cancer. Your family doctor should take a blood test called 25-hydroxy vitamin D level to make sure that you absorb enough vitamin D3. There are slow and fast absorbers and the only thing to know how well your gut absorbs vitamin D3 is in doing this blood test.

Also, curcumin (turmeric) 500 mg once per day is good for cancer prevention.

Take enough fiber

Make sure you take enough fiber, which does not only reduce colorectal cancer, but also many other cancers. When you eat plant-based food, you automatically get fiber in it. North Americans are not consuming enough fiber in their diet.

Avoid processed meat and too much red meat consumption

Processed meat and red meat cause cancer.

Beef, lamb and pork seem to contribute to causing cancer according to the WHO. Use common sense and eat fish, chicken and turkey. Reduce your beef consumption. My grandmother served beef as a Sunday dish.The rest of the week simple, plant-based foods appeared on the table. Ask your grandmother, what she used to cook. Or ask your mother what she ate as a child.

Eat moderate amounts of fruit and vegetables

The claim that fruit and vegetables would protect you from cancer is not as solid as researchers thought of in the past. Newer research has shown that a basic intake of fruit and vegetables is needed for nutrients, but consuming more than that will NOT protect you from cancer.

This link explains that eating more vegetables or fruit beyond a certain point will not do harm, but will not protect you further from cancer.

Drink green tea or black tea

If you like tea, drink green tea or black tea. Sweeten it with stevia, but not with sugar. Tea has been shown to have cancer prevention properties.

Avoid alcohol consumption to prevent cancer.

Coffee is a healthy drink and it has mild anti-cancer effects as well. It does not matter whether you drink it caffeinated or decaffeinated.

Other lifestyle issues

Quit smoking

If you are still smoking, quit smoking! Smoking is by and large the biggest risk for developing lung cancer, throat cancer, esophageal cancer and pancreatic cancer.

Watch your calorie intake

Eat smaller meals more often. This way the production of your digestive juices will consume some calories. In addition your taste buds are satisfied, so your hunger for food is more controlled. The end result is that you will not gain weight.

Prevent obesity and type 2 diabetes

This will help prevent obesity and type 2 diabetes, both of which are established risk factors to develop cancer. Here is a review that shows you, which cancer types are caused by obesity. With regard to diabetes, there is a strong association to developing liver cancer, pancreatic cancer and endometrial cancer (=uterine cancer). There is a lesser risk (only 1.2 to 1.5-fold) to develop cancer of the colon and rectum, breast cancer and bladder cancer.

Pollution

Poor air quality with pollution can also be a factor in causing cancer. Pollution does not stay local, but travels through the stratosphere around the globe. The result is that now 10 to 15% of lung cancer in the US occurs in patients who never smoked. This translates into 16,000 to 24,000 deaths annually of never-smokers in the US. In certain cities such as Beijing lung cancer rates have doubled in 9 years between 2002 and 2011. Lung cancer in non-smokers can be caused from exposure to radon, to second-hand tobacco smoke, and other indoor air pollutants.

Bioidentical hormone replacement

When males do not replace missing testosterone in andropause they are much more prone to develop prostate cancer. Similarly, when women are menopausal and do not get progesterone supplementation, they develop a higher amount of breast cancer due to estrogen dominance. It follows from this that bioidentical hormone replacement in menopause and andropause will help to prevent prostate cancer and breast cancer.

The Best Ways To Prevent Cancer

The Best Ways To Prevent Cancer

Conclusion

There is strong evidence that certain foods can cause cancer. Other foods including supplements like curcumin and vitamin D3 can help prevent cancer. Basically, you want to avoid all that is known to cause cancer and eat more of the healthy foods that do not cause cancer. This will help to decline your cancer risk. I suggest that in addition you should quit smoking, avoid pollution as much as possible, reduce excessive alcohol intake and watch your calorie intake. By doing this you prevent obesity and type 2 diabetes, and you will move into the low-risk cancer group. We all need to work on this on an ongoing basis.

Practical hints regarding the best ways to prevent cancer

The best ways to prevent cancer is to avoid processed red meat and all other processed foods. Eat more vegetables, fruit, wild salmon and other seafood. Don’t eat red meat more often than once a week and make it red meat from grass fed animals. In addition exercise regularly, get enough sleep and practice some form of relaxation (yoga, Tai Chi, self-hypnosis etc.). This lifestyle will not only prevent heart attacks and strokes, but also the majority of cancers.

Previously published here.

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