Jun
15
2019

Replacing Part Of Red Meat With Fish Shows Health Benefits

A Danish study has shown that replacing part of red meat with fish shows health benefits.

The research was done by a PhD student and pointed out that men above the age of 50 were particularly benefitting from fish substituting part of red meat in their diet. Women in the childbearing age also benefitted greatly. On this diet pregnant women as well as the unborn children become healthier.

Risk versus benefit analysis

Sofie Theresa Thomsen, the PhD student who conducted this study did risk-benefit assessments regarding partial substitution of beef with low-mercury fish. Red and processed meat contains saturated fat, which is added to the other saturated fat in the Danish diet. Red meat and processed meats have been associated with colorectal cancer and some other cancers. But red meat also contains beneficial iron. In contrast, fish contains a lot of omega-3 fatty acids that are anti-inflammatory and also contains vitamin D. But one has to be careful about methylmercury content in fish. I reviewed fish, mercury contamination and the benefits in this link.

In her calculations Sofie Theresa Thomsen replaced 350 grams of beef per week with 350 grams of low-mercury fish per week.

If all the Danish households would do this partial beef/fish exchange, the Danes would gain 7,000 healthy years of life annually. This includes, among other health conditions, the prevention of 170 deaths from coronary heart disease.

What kind of fish can you eat?

As the link above shows, there are low, medium and high methylmercury contaminated fish. The higher the fish is in the predator chain, the higher the methylmercury content. This is of particular concern for pregnant women as mercury is toxic for the fetal brain tissue. But they consume low mercury fish and shellfish, like mackerel, herring, wild salmon, shrimps or clams, pregnant women benefit greatly from the beef/fish exchange. Tuna is too high in methylmercury to be included in the beef/fish exchange. If you were to include tuna in this, you would experience a health loss.

Vitamin D and iron

The study showed further that a partial exchange of beef by fish would reduce the number of Danes who are vitamin D deficient. The 350 grams of fish per week are sufficient to significantly raise the vitamin D blood level. Conversely, replacing a part of the beef intake with fish does not cause iron deficiency problems.

Who benefits most from replacing part of red meat by fish?

Sofie Theresa Thomsen asked who would benefit most from such a beef/fish exchange diet.

On the one hand it is the older than 50 year male population who is at a significant risk of developing heart attacks. The fatty fish with omega-3 fatty acids reverses some of the plaque in the arteries and keeps coronary arteries open. This prevents heart attacks and strokes.

On the other hand pregnant women and their children benefit greatly from the beef/fish exchange diet. The women will feel more energy and their offspring will have healthy brains.

Replacing Part Of Red Meat With Fish Shows Health Benefits

Replacing Part Of Red Meat With Fish Shows Health Benefits

Conclusion

A study from Denmark analyzed what happens when a person exchanges 350 grams of beef with low mercury fish or shellfish per week. The conclusion was that Danes would gain 7,000 healthy years of life annually. Among these is the prevention of 170 deaths from coronary heart disease. But the most lives saved would be among men older than 50 years due to heart attack and stroke prevention. Pregnant women are also benefitting tremendously, not only for themselves, but for their children. The fish needs to be low mercury fish, as mentioned above, as mercury is a central nervous system toxin. Tuna is too high in mercury.

I have cut out red meat and meat products from my diet since 2015, when the WHO came out with the statement that red meat causes colorectal cancer. As a result I eat a lot more low mercury seafood and shellfish.

Jun
08
2019

How Can We Prolong Our Lives?

The question “How can we prolong our lives?” is something that fascinates many people. It is not one thing, one activity, one diet, or one lifestyle factor that determines longevity. It is the combination of all of the things listed below that are necessary.

Longevity is partially inherited from your mother

The reason for this is that mitochondria in your body cells come from your mother’s body. As you know, the egg (ovum) contains the mitochondria (the energy packages of the cell). The sperm that is the winner penetrating the ovum is shedding the tail outside the ovum. The tail of the sperm had loads of mitochondria in it to give it the energy to wiggle its way up the Fallopian tube to meet the ovum. This is the reason why we all inherit our mitochondria from our mother. If there is longevity on your mother’s side, you likely will have the longevity gene as well. So, this certainly helps, but on the other hand, we cannot pick our ancestors! Don’t be discouraged! There is enough that you can do.

Diet

The best type of diet is a Mediterranean-type diet. There is a new fasting mimicking diet, that likely turns on latent longevity genes that need to be intermittently activated, if we are serious about wanting to increase longevity. Dr. Longo is the inventor of the fasting mimicking diet. I have discussed this in detail here. Briefly, it consists of eating 500 to 600 calories on 5 consecutive days. The rest of the month you eat normally. The important part is that Dr. Longo has shown in humans that telomeres get elongated by the 5-day protocol per month. Longer telomeres means longer life. This is what we want, because this adds life to our life expectancy!

Lifestyle

Don’t smoke and don’t do drugs. Drugs interfere with our hormone- and other cell surface receptors. Our body cells don’t like artificial chemicals from outside. Don’t overlook the fact, that alcohol is also a drug! Alcohol is a nerve and cell poison. It has been shown to even be toxic, so don’t drink all the time. If you want a drink here and there, you probably get away with it. But binge drinkers (6 drinks or more in one evening) are out of luck; their life expectancy is shorter than that of non-drinkers.

Exercise

Regular exercise recharges your mitochondria to give you extra energy. It conditions your heart and lungs and also your muscles. Many people think exercise would cause weight loss. But it is not leading to that much weight loss at all! What is more important is the fact that it is reducing the overall mortality from many diseases by up to 47%! Exercise also improves blood sugar control, energy levels and sleep patterns. There are also hidden benefits, as the heart is being conditioned and the lungs are improving their vital capacity from regular exercise, particularly aerobic exercises like running or using a treadmill. But muscle strength also benefits from regular exercise.

Get enough sleep

You need 7 to 8 hours of sleep, and it is best to go to sleep between 10 or 11 pm. During your sleep your brain is being renewed and your hormones are reloaded. There is a diurnal hormone rhythm that ensures you have enough energy for the following day. A Swedish study found that white-collar shift workers had a 260% higher mortality compared to a control group of daytime white collar workers: Shift work and mortality.

Vitamins and supplements

Some minimum vitamin and mineral supplements are helpful for longevity: Mornings: 2 capsules of molecularly distilled fish oil (omega-3 fatty acids). Two tablets of vitamin C 500 mg chewable, one capsule of 150mg of chelated magnesium, resveratrol 500mg, vitamin B complex B-50, zinc 30mg, vitamin K2 two capsules of 100 micrograms, vitamin D3 5000IU every morning, CoQ-10 400mg. Evenings: 2 capsules of molecularly distilled fish oil (omega-3 fatty acids). Vitamin B complex B-50, chelated magnesium 150mg, melatonin 3mg to fall asleep, valerian root 500mg capsule (if you have anxious thoughts); you may repeat melatonin and valerian root in the middle of the night, if you wake up at 2AM or 3AM in the morning.

Brief explanation for vitamin and mineral replacement

In case you wonder about the rationale of my suggestion for vitamin and mineral replacement, here is a brief explanation: vitamin C stimulates the adrenal glands and helps support the immune system. You get more energy and get fewer infections. Molecularly distilled fish oil is anti-inflammatory, helps prevent osteoporosis, but also prevents heart attacks by preventing inflammation of the arteries. Magnesium and zinc are co-factors in hundreds of biochemical reactions inside our cells, so this helps your metabolism.

Resveratrol an anti-aging supplement

Resveratrol is a bioflavonoid derived from red grapes. It has multiple beneficial effects. It lowers blood pressure, helps to control diabetes better and prevents osteoporosis. But resveratrol also elongates telomeres, which translated into a longer life and less diseases. B complex vitamins are good for energy and many metabolic processes. Vitamin K2 and vitamin D3 work together to get calcium out of our arteries and deposit calcium into our bones. This prevents osteoporosis, which is particularly important for postmenopausal women, but is also important for men. Resveratrol also prevents heart attacks and strokes. CoQ-10 is important to lower cholesterol, but also supports the metabolism of mitochondria, the energy packages of our cells.

Hormone deficiencies

We all know that there is menopause for women and andropause for men. But there are silent hormone deficiencies that are less well known. For instance melatonin secretion gets reduced fairly quickly after the age of 20. Between the age of 50 and 60 you are basically deficient for melatonin, so using a supplement of melatonin tablets would be very reasonable. Another hormone, namely human growth hormone (HGH) is very likely deficient in us by the time we are 50 to 60 years old. I will deal with this further below.

Menopause

Women get into menopause between 45 and 55, but they can get there earlier or later. Women are missing estrogen and progesterone. Many women were horrified by the Women’s Health Initiative result in 2002. But this trial involved synthetic hormones that the body did not like. So women got breast cancer, colon cancer, heart attacks and strokes from Premarin and Provera, both synthetic hormones. Had physicians been sensible and put them on bioidentical hormones instead, they would have prevented heart attacks, strokes and osteoporosis. They would also have prevented breast cancer and colon cancer. The proper way to replace missing hormones in women with menopause is to replace them with bioidentical progesterone cream and bioidentical estrogen cream.

Andropause

Men get into andropause between 55 and 65. The testicles will no longer provide the man with enough testosterone. This leads to lack of sex drive, erectile dysfunction, but also to more heart attacks, muscle weakness and a lack of energy. The problem is that there is not enough testosterone to stimulate the mitochondria. Mitochondria are very prominent in the heart muscle, skeletal muscles, but also in the brain. When the doctor confirms a lack of testosterone with blood tests, he orders replacement with bioidentical testosterone cream or by a simple testosterone injection twice per week. The man will feel better after a short period of time (4 to 6 weeks) as all his functions return back to normal.

Many speakers at anti-aging conferences, which I attend every December in Las Vegas, seem to agree that bioidentical hormone replacement adds 10 to 15 years of life both in men and women. It also gives people renewed energy, and they look younger.

Human growth hormone

Many people do not know that human growth hormone (HGH) is important for longevity in adults. In childhood it was important for bone growth. Growth hormone deficiency is the one factor that has been underestimated. The discussion of dwarfs in comparison to their healthy brothers and sisters showed us the following. Growth hormone production can add between 19 and 34 years (average 26.5 years) of life. Dr. Hertoghe, an endocrinologist from Belgium has done blood tests (IGF-1) and lately also 24-hour urine metabolite tests of growth hormone on aging patients and found that many were deficient with regard to HGH production. These were patients where Dr. Hertoghe already replaced their thyroid hormones, if abnormal and replaced their sex hormones when they were low.

Symptoms of human growth hormone deficiency

But they lost hair, developed old looking faces with wrinkles. In addition, a loss of subcutaneous fatty tissue is giving the face a hollow appearance. They also had muscle and joint pains and thin skin, particularly over the back of their hands.

Replacement of growth hormone

He replaced their missing HGH using daily HGH self-injection with a tiny needle (similar to diabetes injections). Within 1.5 to 3 years the wrinkles disappeared, the faces started to look younger and patients did feel younger. Their muscle and joint pains had disappeared and their hair grew back. The dosage range is between 0.1mg and 0.3mg, a tiny amount of HGH daily. This is not inexpensive, but some health care plans pay for this, as a lack of HGH is a true hormone deficiency.

How Can We Prolong Our Lives?

How Can We Prolong Our Lives?

Conclusion

I have given you an overview of the important elements of what increases longevity. The key is to have a healthy, balanced diet and leave junk food out. Don’t smoke and don’t drink excessive amounts of alcohol. No alcohol consumption would be best, because alcohol essentially is a nerve poison and can lead to dementia. Exercise regularly to lower mortality and strengthen your heart and lungs. Get enough rest and sleep to refresh your diurnal hormone rhythm. When we age, it is important to keep an eye on our hormones. You need a physician who is knowledgeable about it.

Hormone replacement

Hormones that are missing need to be replaced by bioidentical hormones. In addition you need to know what the level of IGF-1 is. HGH controls the IGF-1 level. If IGF-1 is low, you need HGH replacement. Studies have shown that replacement of missing HGH may be able to add 2 decades of good life. All of the other hormones replaced by bioidentical hormones will add 10 to 15 years. As stated in the beginning, there is not one thing only that increases longevity, but a combination of all these factors.

First published here: https://www.quora.com/What-increases-longevity/answer/Ray-Schilling

May
26
2019

The Foods That Are Killing Us

There is an article in a CNN report talking about the foods that are killing us. This review is based on an article in the Lancet. The Lancet study was based on a global review of eating habits in 195 countries. The question in the study was which of 15 food items caused the diseases that killed people. The answer was surprising. There are either omissions or unhealthy components of foods that kill us. Here is a list of 12 food groups that are problematical.

A dozen foods that were found to be problematical in the global review

  • Diet high in sodium (4 grams per day, which is 86% above the optimal level)
  • Low intake of whole grains (only 23% of optimal levels)
  • Low fruit intake
  • Diet high in trans fatty acids
  • Low omega-3 fatty acid diet (due to low intake of sea food)
  • Diet low in calcium
  • Diet low in fiber
  • High intake of sugar beverages or sugary foods (49 grams of sugar per day)
  • Processed meat intake too high (4 grams per day, 90% more than optimal)
  • Red meat consumption too high (27 grams per day, 18% higher than optimal)
  • Nut and seed intake too low (only consuming 12% of desired amount)
  • Diet low in milk (16% of desired amount)

Each of these components or several of them in combination create deficiencies in us or overburden us to the point where we can get sick and disabled.

Different countries have different eating habits

Globally there were 11 million deaths found in 2017 and 255 million years of disability because of various dietary inadequacies.

Here is the lineup of the leading causes of death:

  • cardiovascular disease with 10 million deaths and 207 million years of disability.
  • Cancers caused 913,090 deaths and 20 million years of disability.
  • Type 2 diabetes caused 338,714 deaths and 24 million years of disability.

This was broken down into statistics for each of the contributory countries. Here I am only citing some pertinent data that shows the importance of balanced meals for a healthy life expectancy.

Different death rates in various countries

There were big differences in terms of cardiovascular disease deaths according to various regions. Central Asia had the highest death rate with 613 deaths per 100,000 people per year. In contrast the high-income Asia Pacific group had only a cardiovascular death rate of 68 per 100,000 people per year.

Cancer deaths were highest in East Asia with 41 deaths per 100,000 people. The lowest cancer rate was found in North Africa and the Middle East with 9 deaths per 100,000 people.

Among the 20 most populous countries Egypt had the highest diet-related deaths, namely 552 deaths per 100,000 people. On the other hand Japan had the lowest of all diet related deaths with 97 deaths per 100,000 people. 

Some highlights how unhealthy foods kill us

Globally people only eat 12% of the desirable amount of nuts and seeds. They only drink 13% of what they should consume in terms of milk. People worldwide eat 23% of the desirable amount of whole grains.

Nuts and seeds contain mono- and polyunsaturated fats and omega-3 fatty acids, which lower your risk of getting heart attacks and strokes.

Milk is a good source of calcium, protein, minerals and vitamins. However, milk, yogurt or cheese should be consumed as low fat varieties. Alternatively people who do not consume milk should look for protein carriers such as soy milk or pea milk.

If you eat nuts and vegetables you can largely compensate for low milk consumption. If you don’t get enough whole grains, you are missing a whole lot of nutrients. This makes you more vulnerable of getting cardiovascular disease, hypertension, type 2 diabetes, colon cancer, and obesity.

Other unhealthy foods can kill us

The WHO has labelled red meat and processed meat as being carcinogenic

Studies clearly showed a higher than normal rate of colorectal cancer in those who consumed larger amounts of red meat and/or sausages.

Sugar overconsumption

Sugar overconsumption leads to a variety of conditions. Weight gain with the development of obesity and type 2 diabetes are common when you eat too much sugar. But even cancer like colorectal cancer and pancreatic cancer is more common in people who overindulge in sugar or sugary drinks. Sugar consumption raises your triglyceride and LDL level. This will eventually lead to hardening of the arteries, heart attacks and strokes.

Gout develops with purine containing foods

Gout can be caused by consuming a lot of red meat combined with copious amounts of beer. This is how royalty in the Middle Ages suffered from gout attacks. Gout had the nickname of “Disease of the affluent.” Both beer and red meat contain a lot of purines, which the kidneys cannot handle. The uric acid crystals that precipitate around joints cause excruciating pains.

 What the global health study showed

Researchers of the global health study stated that improving the diet habits could potentially eliminate 1 in 5 deaths globally. Dietary risks for major diseases like heart attacks, strokes and cancer are independent from sex, age and socioeconomic status.

Three dietary factors stood out: too much salt, too little fruit and too little whole grain. These three items were responsible for 50% of diet-related deaths and 66% of “disability-adjusted life years”. The authors used this expression to describe how years of disability had their root in diet deficits (e.g. too little fruit) or overdoses of unhealthy food components (e.g. salt).

The leading dietary risk factors are too much salt, low whole grain, low fruit consumption, low vegetable intake and low omega-3 fatty acid consumption. On top of that come the previously established risks due to sugar overconsumption, excessive fat intake and consumption of red meat and processed meat.

Discussion of the meaning of these results

Deaths from heart attacks and strokes

We know for some time that high sugar and high starchy food intake cause elevated triglycerides and elevated LDL cholesterol. This leads to hardening of the arteries and eventually to strokes and heart attacks.

High sodium intake

Sodium intake of more than 2300 mg per day is considered high and can cause high blood pressure. heart attacks, strokes and aneurysms.

Eating not enough fruit

If you eat too little fruit, your system does not get enough vitamin C and other vitamins. Heart disease, cancer and anemia could develop from that.

Eating not enough vegetables

People who do not eat enough vegetables do not have enough antioxidants that protect them from free radicals. Free radicals are unstable chemicals that attack cells and DNA. Mutated cells can cause cancer. If you eat too little vegetables, you are at a higher risk of getting cancer. But there is another aspect of vegetables: phytonutrients protect from hardening of the arteries and blockages of heart and brain vessels. When someone does not eat enough vegetables, the risk for heart attacks and strokes is higher. Eating vegetables also protects you from diabetes and keeps the blood sugar more stable.

Not eating enough whole grain

Whole grain was identified as missing in a lot of people’s diet. When you incorporate whole grains into your food, you reduce the risk of cardiovascular disease, hypertension, type 2 diabetes, colon cancer, and obesity.

There are vitamins, minerals, dietary fiber and lignans in whole grain. Other nutrients are beta-glucan, several phytochemicals, phytosterols, phytin, and sphingolipids. All of these are necessary to maintain good health.

Low omega-3 fatty acid consumption

Omega-3 fatty acids are important for healthy skin, brain development (neurodevelopment of children) and prevention of heart attacks. Omega-3 fatty acids reduce the risk of cancer because of their anti-inflammatory action and inhibition of cell growth factors. In one study rectal cancer showed a 21% reduction comparing the highest omega-3 fatty acid intake to the lowest intake of omega-3 fatty acids. Colon cancer showed no effect to omega-3 consumption, but breast cancer showed a reduction with omega-3 fatty acid supplementation. Researchers showed that omega-3 fatty acid supplementation can slow down dementia and Alzheimer’s disease. Protein deposits called amyloids were found less in the brain of patients with omega-3 fatty acid supplementation; in addition the brain volume was preserved more with the omega-3 supplement. Low omega-3 fatty acid consumption also has a detrimental effect on macular degeneration of the eyes and on joint pains of rheumatoid arthritis patients.

The Foods That Are Killing Us

The Foods That Are Killing Us

Conclusion

I have reviewed a global health study that described various risks that led to deaths from different diseases. It was noticeable that death and disability rates varied significantly according to different countries. The authors also looked into food habits and could pinpoint certain food deficiencies that caused diseases that prematurely disabled or killed people. I have described the various one-sided food habits that led to specific diseases.

What we should all learn from this complicated study is that we all can strive to eat more balanced meals. You want to eat a low sodium diet, eat enough fruit and vegetables, to which you add some nuts. Eat enough whole grains and add omega-3 fatty acids. This way the risk of getting cancer, cardiovascular diseases or other problems can be significantly reduced.

May
18
2019

A Pill Against Obesity

At the 26th European Congress on Obesity in Glasgow, Scotland a pill against obesity was introduced. Here is a report about this on CNN. The biotechnology company, Gelesis had funded the research. This company also developed the product. The FDA has accepted this product, which is marketed under the name “Plenity”. The FDA gave clearance for Plenity as a prescription weight loss product for use in overweight adults with a body mass index above 25.0. Genesis has announced that Plenity will be available in the US by 2020. The cost of it is yet unknown.

How Plenity, a pill against obesity, works

Plenity actually is a medical device. It is a capsule that contains tiny little gel pieces that dissolve in the stomach. Patients take one capsule with water before lunch and dinner. When the gel pieces swell it gives a fullness feeling that limits calorie intake. The hydrogel pieces increase the volume of the stomach and small intestine. By the time the gel particles arrive in the large intestine, enzymes have partially broken down the hydrogel, water is released and the rest is expelled in the feces. Dr. Ken Fujioka, a weight loss expert, endocrinology researcher at Scripps Clinic and scientific advisor to Gelesis said: ”The most compelling aspects of this approach are its effectiveness, novel mechanism of action and impressive safety data. This approach creates another arm in the treatment algorithm of weight management and could be used by an overwhelming majority of people struggling with weight issues”.

Randomized placebo controlled weight loss study with Plenity

Gelesis sponsored a weight loss study with 223 patients in the experimental group and 213 in the placebo group. The length of the weight loss study was 171 days. The placebo group lost 4.39% body weight, while the group on Plenity lost 6.41%. There were very few side effects, like an abdominal fullness or bloating.

Discussion regarding Plenity, a pill against obesity

Along with taking Plenity the investigators asked the patients to also stay physically active and adhere to a sensible diet. I know from my own experience that a change in diet can make you shed significant weight and you can keep it down. In 2001 I lost 22.7 kg (=50 pounds) over 3 months, down from 85.5 kg. I weigh now 62.8 kg. With this data you can calculate that I lost 22.7/85.5=26.5% of my original weight. I did so in 90 days, not in 171. It was the difference in food intake that enabled me to lose this weight. I had cut out all sugar, starchy foods, processed food and wheat.

The pill will help patients feel full after smaller helpings, instead of having hunger pangs, and this can be valuable and will contribute to being successful with losing weight. But long-term weight control only works with an adjustment of dietary habits and lifestyle choices. 

Keeping weight loss in perspective

The authors stated that their best patients were losing 5% and 10% when they watched their diet and exercised. When I compare my own data (26.5% weight loss) and theirs I conclude that they did not try hard enough. And they did not have to rely on any diet pills. It is clear from the data that the placebo group had significant weight loss with just watching their diet and exercising. I do acknowledge that Plenity has a slightly better effect. However, when people complete with their weight loss program, they will continue to eat their former diet regimen. This will make them gain everything back what they have lost.

For 18 years I have not gained back what I lost in 2001 because I have stayed on the same diet that some people may label as “radical”. There is nothing wrong with vegetables, salads, lean poultry, fish, nuts, fruit etc. I suspect that people could easily lose 10% to 20% of weight without any weight loss pills, if they took a similar approach as I did.

A Pill Against Obesity

A Pill Against Obesity

Conclusion

Weight loss seems to be a topic that is of interest to many people. There is the expectation that the new weight loss pill Plenity will be the solution to people’s diet problems. However, the difference in weight loss between the placebo group and the experimental group was only 2.02%! It took the researchers 171 days to be able to say that there was a significant difference between the Plenity group and the placebo group.

Cutting out junk foods

When I did my own weight loss program based on dietary changes alone I had lost 26.5% in only 90 days. I suggest that people should not forget to change their food intake, cutting out junk food and adopting a healthy food intake. They may not require Plenity pills at all or for a much shorter time. Preparations for the time after the weight loss achievement are necessary or else there will be rebound weight gain. Long-term success is only possible with sensible dietary choices and lifestyle choices, such as regular physical activity.

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May
11
2019

Male Fertility Could Be Improved Naturally

A review article of CNN reviewed how male fertility could be improved naturally. Studies have shown that males contribute about 40 to 50% of the responsibility of any fertility problem of the couple. This means that a couple with infertility issues will benefit from interventions that include the male partner. Dr. Natan Bar-Chama is the director of the Center of Male Reproductive Health in New York. He is a board-certified urologist and male infertility specialist. Dr. Bar-Chama has done research into what affects male fertility. He found that there are several factors that are important for male fertility.

Lifestyle factors

The big factors that interfere with fertility are obesity, caffeine and alcohol intake, smoking, marijuana intake, lack of exercise and wearing too tight underwear resulting in increased scrotal temperature.

Obesity

Overconsumption of refined carbs like sugar and processed foods leads to obesity. The best for him is to change his diet to a Mediterranean diet. This supports weight loss and at the same time improves sperm quality.

Obese men tend to father children that often are not viable. It may be that it is due to genetic changes in the sperm in obese men. These changes can affect fertilization, but also embryo development. Researchers have detected sperm DNA fragmentation in sperm from obese men, which can lead to pregnancy loss. Weight loss in obese men improves sperm quality.

Caffeine and alcohol intake

More than 1 or 2 cups of coffee a day relates directly to difficulties for a couple to conceive. When it comes to alcohol intake, the male should not drink more than one glass of wine or the equivalent of alcohol in beer or spirits per day. Higher consumption results in male infertility due to poor sperm quality. Physicians have warned women for a long time that they should stop drinking alcoholic beverages, if they want to become pregnant. It is best, if both partners don’t drink for the sake of a healthy pregnancy.

Smoking

Stop tobacco and drug use. Smoking and drug abuse have been consistently shown to be bad for sperm quality and are associated with infertility. Marijuana use leads to low sperm counts, which is a cause of infertility.

Lack of exercise

Moderate aerobic exercise and resistance exercise can improve sperm quality.

However, excessive exercise has shown negative effects on sperm. Bicycling for 5 hours or more has been shown to reduce sperm quality due to the heating up of the scrotum and the testicular tissue. For the same reason men wearing boxer shorts instead of tight underpants were observed to have higher sperm concentration and sperm counts.

Antioxidants

Oxidative stress can damage sperm. This involves smoking, a junk food diet, obesity, pollution, radiation and heavy metals like mercury from big game fish (like tuna, shark, sable fish, sword fish etc.). Dr. Bar-Chama said: ”When you cause damage to cell membranes, you are impacting the ability of the sperm to attach, penetrate and activate the complex fertilization process”. In order to counter these negative effects of the environment it is helpful to take antioxidants.

Some of the common antioxidants are: vitamin C and E, beta-carotene, selenium, zinc, folic acid, lycopene and coenzyme Q-10. If you get 5 servings of fruit and vegetables, you get most of the antioxidant vitamins and minerals. You find selenium in Brazil nuts, sardines and halibut. Oysters, dark-meat poultry, crab, and fortified cereals contain zinc, which supports male fertility.

Omega-3 fatty acids

Omega-3 fatty acids from fish and seafood has been shown to increase the success rate of couples who want to get pregnant. Low mercury seafood like scallops, clams, shrimp, oyster, sardines, salmon and squid are a good source of omega-3 fatty acid.

Get some nuts

A handful of nuts or two also helps the male to produce more healthy sperm. This study showed that nut consumption improved the total sperm count. In addition, it increased vitality, motility, and morphology of the sperm.

Cut out processed meats

Another study showed that consumption of processed meat had a negative association with fertility rates in couples that desired children. However, eating chicken instead of processed meat gave the fertility rates a boost.

 

Male Fertility Could Be Improved Naturally

Male Fertility Could Be Improved Naturally

Conclusion

We have been lulled into thinking that when there are fertility problems in a marriage, it would likely be due to female reproductive problems. This kind of thinking is old school and has been disqualified by newer research. It turns out that often the problem originates from the man, if he is unwilling to change his lifestyle to get ready to father a child. As outlined above there are quite a few factors that interfere with sperm production and motility of the sperm. If he wants to father a child, he needs to take good care of his sperm by adopting healthy lifestyles. Sperm, it turns out are much more vulnerable to toxic changes, heat from tight clothing, and nutritional deficiencies.

Healthy food for the man results in a healthy child

Not everything is exclusively the responsibility of the female. The male also needs to eat balanced meals and might also benefit from some antioxidants and supplements. Omega-3 fatty acids from nuts and seafood are also good for sperm production and motility. Add some moderate physical exercise, and he will be ready to father a child. It is very much a team effort, as both parents- to- be have to do their part and embrace a healthy lifestyle.

Apr
20
2019

Some Reasons For Variations In Cancer Rates

It can be confusing to see that various countries have big differences in cancer rates, but here I am giving some reasons for variations in cancer rates.

The following countries have high cancer rates: Denmark, France, Belgium, United States, Hungary, Ireland, New Zealand, Australia.

These countries have low cancer rates: Niger, Yemen, Oman, Nepal, Mauritania, Gambia, Cape VerSe, Bhutan. These are only samples; it is not a complete list.

Short life expectancy in many low cancer rate countries

People in many low cancer rate countries do not live long lives because of parasitic infestations, bacterial infections and AIDS. Life expectancy in Gambia, for instance is only 61.15 years. People in Yemen suffer from malnutrition and the life expectancy is only 64.95 years. One can make an argument therefore that people do not live long enough to get a lot of cancer. Cancer is a disease of the older population, as DNA mutations, shorter telomeres, and loss of mitochondria in older cells cause many cancers.

These three countries have various cancer rates

Low cancer rates in India

India is one of the countries with lower cancer rates when compared to the US. Scientists have pointed out that 40% of Indians are consuming vegetarian diets without meat; (red meat consumed in high amounts like in the US is carcinogenic). India has some of the highest spice consumption in the world. We know that curcumin, for instance, has cancer-preventing qualities. You could say that Indians inadvertently treat themselves with herbal, non-toxic chemotherapy (curcumin and others spices) before a cancer even occurs. On the other hand India is a nation with high consumption of refined sugar, which is a factor that can cause cancer over a long period of time. The life expectancy in India is only 68.56 years, which skews the statistics towards lower cancer rates when one compares India to countries with a life expectancy of 80.0 years.

Why is Denmark a high cancer rate country?

The biggest factors are a reliable cancer reporting system, but also a high smoking rate among Danish women and high alcohol consumption in the Danish population. See below what these factors do.

Why is Oman a low cancer rate country?

A study done in Oman showed that a lot of people do not know that certain risk factors could be changed to lower the present cancer incidence. Cigarette smoking, passive smoking, excessive alcohol consumption, reduced intake of fruit and vegetables, increased consumption of red meat and processed meats, infection with HPV, being overweight, less physical activity and an age above 70 are all risk factors for cancer. At the present time Oman still compares favorably with the US, as there is less obesity in Oman. But the average person still eats fairly healthy with an emphasis on fruit and vegetables.

Increasing cancer rates in Oman

The cigarette consumption per year per person in Oman is 271.1 versus 1016.6 in the US. The life expectancy has increased from 50.47 in 1970 to 77.03 in 2016. Oman is expecting the cancer rate to double by the year 2030 due to the increasing life expectancy and lifestyle factors (more drinking, smoking and gaining weight from junk food). A lot of the differences in the cancer rates between the US and Oman are simply due to lifestyle differences. 

Cancer risk factors analyzed

What do the various cancer risks mean in terms of cancer development?

Cigarette smoking

About 480,000 premature deaths are caused by cigarette smoking in the US. This is due to a combination of cancer, heart attacks and strokes. Smoking causes cancers of the lung, esophagus, larynx, mouth, throat, kidney, bladder, liver, pancreas, stomach, cervix, colon, rectum, but also acute myeloid leukemia.

Passive smoking

Passive smoking is as bad, if not worse than smoking. This reference explains that a passive smoker has double exposure to cigarette smoke, namely to the smoke from the smoker, but also to the direct smoke from the burning cigarette. This means that a passive smoker may have exposure to a higher concentration of carcinogens than the smoker!

Excessive alcohol consumption

Heavy alcohol consumption introduces a cell poison into your body. If you drink more than 8 drinks per week as a woman or more than 15 drinks per week as a man, you are a heavy drinker. It leads to cancer of the mouth, esophagus, throat, colon, liver, breast and prostate. The data on prostate cancer is somewhat weaker.

Reduced intake of fruit and vegetables

Consumption of fruits and vegetables, but also foods high in fibre are known to reduce the risk of cancer. This is why the WHO brought out this fact sheet. So, when you lower the intake of fruits and vegetables, you have less of a cancer protective effect, which leads to more cancer.

Increased consumption of red meat and processed meats

Another big factor about cancer causation is when you eat foods that contain known carcinogens. Such cancer causing substances are contained in red meat, processed meat like sausages, and salt-preserved foods.

Infection with HPV

Type 16 and 18 HPV virus is the cause of cervical cancer, penile cancer, oropharyngeal cancer, anal cancer, vulvar and vaginal cancer. It can be of concern for all sexually active people.

Being overweight

When a person gets overweight or obese, there is more estrogen production from the fat cells that circulate in your blood.  There is also more insulin production and IGF-1 production, which is a growth factor for cancer cells. Estrogen dominance due to estrogen production from fat cells with a relative lack of cancer-controlling progesterone tips the balance towards cancer development. These are the cancers that are common in obesity: breast (in women past menopause), colon and rectum, endometrium (lining of the uterus), esophagus, kidneys and pancreas.

Less physical activity

Breast cancer and colon cancer are reduced when people exercise regularly. This seems to be because of a reduction in circulating estrogen in women and because of reduced insulin and insulin-like growth factors. Even prostate cancer can be kept at bay with a regular brisk walk.

An age above 70

The medium age for cancer diagnosis is 66 years. This means that half of the cases are below this age, the other half above it.  25% of new cancer cases are diagnosed in the age group of 65 to 74. Age is an independent, but important risk factor for the development of cancer.

Sugar and starchy food consumption

Refined sugar and starchy foods lead to an accumulation of fat. At the same time there is a metabolic change with more insulin production and growth factors appear in the blood. It is these growth factors and an increase in estrogen (via aromatase) from the fat cells that lead to conditions that favor cancer development. Switch to a low-glycemic diet like a Mediterranean diet, and you can reverse this process.

Some Reasons For Variations In Cancer Rates

Some Reasons For Variations In Cancer Rates

Conclusion

It is never too late to reduce your cancer risk. No matter how old we are, it is never too late to live healthier, which translates into a stronger immune system. We can stop smoking, or cut out drinking too much. If we keep a healthy weight and eat a healthy diet we will stop chronic inflammation in our bodies and strengthen our immune system. We need to stay away from ultraviolet light (direct sun exposure). We also need to stay active, no matter whether it is choosing to take the stairs and take daily walks, or whether we exercise regularly in a gym.

Apr
06
2019

Healthier After Age 60

Unhealthy lifestyles have staying power, so what can we do be healthier after age 60? A recent CNN article describes 10 ways how to adopt a healthier lifestyle when you get close to retirement.

The thinking is that 5 years before your retirement at 65 you should perhaps adopt a healthier lifestyle.

2017 study by Dr. King regarding lifestyles before and after retirement

Dr. Dana King was the author of a 2017 study where lifestyles before and after retirement were compared.

Seven factors were examined, namely cardiovascular factors including physical activity, healthy diet, healthy weight, smoking status, total cholesterol, glucose, and blood pressure. Retirees were more likely to have poorly controlled blood pressures compared to non-retirees. 23.9% of retirees had uncontrolled blood pressure versus 15.1% of non-retirees. This difference was statistically significant. There was another significant difference with regard to physical activity. Retirees were 1.85-fold more active than non-retirees. But sadly, the other 5 of the 7 points did not significantly improve. There were no differences in healthy weight, smoking rates, healthy diet, glucose levels or cholesterol control.

Healthier after age 60: how to change your diet

Adopt a Mediterranean diet. This is an anti-inflammatory diet that prevents hardening of the arteries. It lowers the bad LDL cholesterol and also triglycerides. It is also recommended to consume at least 2 tablespoons of olive oil per day. When you cook only with olive oil and use only olive oil and Balsamic vinegar for salads, it is relatively easy to reach or surpass the recommended 2 daily tablespoons of olive oil.

Healthier after age 60: how to change your exercise status

You have more time when you retire. The easiest to get into a routine regarding regular exercise is to get a membership in a gym. In the beginning you may want to see a trainer to show you some routine exercises on weight machines. You start the program off with 30 minutes on the treadmill. Before long you get used to the exercise routine and you feel stronger. But your system also produces much more of the protective HDL cholesterol, which is sensitive to regular exercise. If you have been physically inactive, get some input from your health care provider.

Healthier after age 60: how to change your weight

It is not exercise, but a healthy diet, which controls your weight. Having adopted a Mediterranean diet is a big first step in that direction. But it is also important to cut out sugar and starchy foods (potatoes, rice, bread, muffins, pasta etc.). This will reduce your LDL cholesterol and triglycerides. On the long term you prevent heart attacks and strokes.

Healthier after age 60: how to change your smoking status

It is old knowledge that smoking cuts down on life expectancy. Better quit smoking now than later. It prevents heart attacks, strokes, lung cancer and many other cancers.

Healthier after age 60: how to lower your blood pressure

Regular exercise, weight loss and quitting to smoke will all lower your blood pressure. Some people though continue to have high blood pressure. It is important to seek medical advice regarding this. People with persistent elevated blood pressure need medication to have this controlled in order to avoid getting a hemorrhagic stroke.

Healthier after age 60: how to lower your glucose levels

The diet I described will help you to control your blood sugars. Your doctor can order a hemoglobin A1C, which summarizes your average blood sugars over the past 3 months. Controlling your blood sugar is important to prevent type 2 diabetes. Diabetes reduces your life expectancy significantly. The risks are heart attacks, strokes, blindness, leg amputations, kidney damage and cancers.

Healthier after age 60: how to lower your cholesterol

When I discussed a healthy diet, I indicted that it lowers the LDL cholesterol and triglycerides. This reduces the risk of hardening of the arteries. A regular exercise program increases the protective HDL cholesterol, which reinforces the protection from heart attacks and strokes.

Healthier After Age 60

Healthier After Age 60

Conclusion

Whether we retire or not, we should all strife to achieve these 7 changes of lifestyle that Dr. Dana King has discussed. They were cardiovascular factors including physical activity, healthy diet, healthy weight, smoking status, total cholesterol, glucose, and blood pressure. Each of these factors is important on its own. But when you tackle all of them simultaneously, there is a potentiation of these factors that allows you to get super-healthy. That’s what you want for your life after age 60. It is not too late to start! You want to be healthier after age 60!

Mar
30
2019

Obesity Fuels Cancer Development

A recent review by the American Cancer Society found that obesity fuels cancer development. As a matter of fact, what the researchers found was that younger millennials are more in danger of both getting obese and of getting obesity related cancers. Also, the rates of baby boomers with respect to obesity-related cancer were much lower than rates from millennials.

Results of the study showing obesity fuels cancer development

In like manner, as the summary by CNN shows, there is an increase of obesity and also an increase of various cancers of the population of millennials versus the same age group among baby boomers. As an illustration, take pancreatic cancer, one of the obesity related cancers. Normally it occurs in people above the age of 65. Here is the increase of frequencies according to age group:

Ages 25 to 29: 4.34% increase.

People aged 30 to 34: 2.47% increase.

Age bracket 35 to 39: 1.31% increase.

Those aged 40 to 44 years: 0.72% increase.

With this in mind you can see clearly that the younger age group is at a higher risk for developing pancreatic cancer. Certainly, the problem is that obesity in children has become more rampant and this has led to early obesity by the age of 35. The other side of the coin in this case is an increased pancreatic cancer rate.

Other cancers that are obesity-related

Indeed, 6 out of 12 obesity related cancers have shown an increase in frequency because of increasing obesity. These cancers are: multiple myeloma, colorectal cancer, uterine cancer, gallbladder, kidney, and pancreatic cancer.

Notably, people born around 1985 had a higher rate of multiple myeloma and kidney cancer than people born around 1950. Multiple myeloma was 1.59-fold higher and kidney cancer 4.91-fold higher in the group of people born around 1985 in comparison to people born around 1950.

Cancer associated with obesity, but may not be caused by obesity

MD Anderson Cancer Center’s Dr. George Chang, who was not associated with the analysis cautioned: “The study was not set up to establish causation. We know there are many factors that have an association with both obesity and cancer, such as lack of exercise and poor diet. How much each of those factors contribute to cancer is less clear.” Specifically, the study found that the rate of obesity-related cancers in millennials now is about double the rate of what it was in baby-boomers at the same age.

Discussion of the obesity and cancer problem

  1. First of all, obesity is now starting in childhood, teenagers and young adults. 5 of the 6 obesity related cancers (colorectal, uterine, gallbladder, kidney and pancreatic cancer) have increased in the younger population. These require mostly surgery and according to Dr. Chang, who is an oncological surgeon, complication rates are higher among obese patients. Dr. Chang added that chances are also that complications will be more severe.
  2. Secondly, we need government-sponsored programs to reverse the obesity trend. This should include changing the diet from the Standard American diet (essentially junk food) to a Mediterranean diet. There should be an elimination of sugar and starchy foods or the use should be just a bare minimum. Reducing or even eliminating red meat is definitely necessary. The WHO has determined that beef, pork and lamb are causing cancer, because they contain weak carcinogens.  Coupled with this is the necessity to initiated regular exercise programs.
  3. Thirdly, fatty tissue in obese patients release growth factors and proteins that function as hormone-like factors stimulating cell growth. These factors stimulate any carcinogenic process. Researchers are still actively working on analyzing this process further.
Obesity Fuels Cancer Development

Obesity Fuels Cancer Development

Conclusion

Childhood obesity has already had the result that obesity-related cancers (multiple myeloma, colorectal cancer, uterine cancer, gallbladder, kidney, and pancreatic cancer) occur at a younger age and more frequently. The cancer rate among obese millennials now is already double the number of what the baby-boomers was at the same age. The key is to treat obesity aggressively with regular fitness programs and with a major diet shift. We know what caused the obesity wave. It is overconsumption of sugar, junk foods, starchy foods, processed foods and fat overuse.

A major change in diet

This means the kids need to cut out sugar. An alternative is to sweeten only with stevia, if they need a sweet taste. They also need to cut out starchy foods like potatoes, pasta, rice, bread and processed food. Processed food contains a lot of sugar and gluten from wheat. Gluten and sugar both stimulate the appetite center. This is what we want to avoid. What remains is a Mediterranean diet without the junk from the North American diet. You end up eating a lot of vegetables, salads and fruit. Fish is a good protein source, poultry as well. Implementing these changes will show positive results for the health of the entire population, not only the millennials.

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Mar
09
2019

Live The Life That We Evolved For

A review article at CNN by a psychiatrist recommends that we live the life that we evolved for. Dr. Arash Javanbakht, an assistant professor of psychiatry at Wayne State University in Detroit, MI explains that man lived on this planet only since 200,000 years. But it takes about 1 million years for evolutionary changes to take place. As a result of this we tend to still behave in our lives the way we may have reacted 10,000 years ago. It is useful to think back of us being hunters and gatherers.

Anxiety, an ancient emotion

Anxiety, for instance, is an emotion that goes far back to 10,000 years ago when humans had to be part of the tribe. If an opposite tribe was fighting them chances were high that they could get killed. Even if your own tribe did no longer like you, there was a strong possibility that you were driven out or killed. This left us with an inheritance going back many millennia of anxiety. In modern life though it is the boss who does not like something you did. It could be a deadline for a school or college project that makes us anxious or some political news. The reasons have changed, but anxiety is still there!

Live the life that we evolved for: assess what we eat

Food was very scarce 10,000 years ago. When the tribe finally caught some prey, there was a feast where fatty food, meat, vegetables, fruit, nuts and seeds were eaten. Refined sugars were not available. You did not know when the next time would come where you had ample food. Today we still behave this way: we eat what we can and eat some more. The only problem is that there is no longer the pattern of famine orfeast. Instead there is easy access to the fridge with all kinds of food. We also have access to fast food places. And we drink sodas, eat candies and other sweets. Eventually we end up fat and fatigued.

Live the life that we evolved for: which way do we move?

Our ancestors had to run and walk many miles a day to find food. They may have been attacked by wild animals and had to flee. They also needed to chase a prey for food. Constant movement was the order of the day. What are we doing today? We did not evolve to step into a car and drive to work. We also did not evolve to sit at a desk from 9AM to 5PM. In the evening we sit in front of the TV or lie on a couch eating munchies and drinking beer.

Our modern life

It is no wonder that we gain weight, that our heart and lungs do not get conditioned, and that our muscles are a pile of mush. We need to think back what our bodies were built to do. Perhaps a long walk would be healthier than sitting all the time. Some of us do not mind to visit a gym daily and build an exercise routine into the day. This mimics the activities of the hunter/gatherers and is a lot better for our bodies.

Live the life that we evolved for: sleep problems

Many people today have problems to fall asleep. The sun had 100% control of the diurnal rhythm in the past. Now we have artificial lightning, blue light from TV’s, computer screens and iPhones. We are constantly getting stimulated. In addition, the stories we read or see on TV get us excited, so that the stress hormone, cortisol is released and melatonin, the sleeping hormone gets suppressed. Taken all this together, it is not really a wonder we have problems sleeping. Relaxation methods can help us to tone down before we go to sleep. You may want to meditate, do self-hypnosis, practice some yoga or just lie still and relax, clearing your mind, and more importantly switch the TV off and put the computer on “sleep”. Sleep for you comes easier this way.

Live the life that we evolved for: our fears

10,000 years ago fear was a normal part of our lives. There were predators you had to fear. There were tribal wars where you had to fight for your survival. You had to fear starvation. The fight/flight response was a reality. Compare this to our lives now. We may fear an exam, a meeting at work or agonize what to wear for a party. We have no real existential fears unless you live in a war zone. Many people may feel that they do not have enough fear in their lives, so they get drawn to horror and mystery stories, computer games, haunted houses etc. But this is fodder for anxiety!

Live the life that we evolved for: how to feel better

When we adopt a pet, let’s say a dog, we understand that it needs food, exercise, love and sleep. But when it comes to the human animal in us, we find it hard to understand that we need that too. In fact, we need to live the life that we evolved for. We need some form of exercise all the time, because that is what we were meant to do 10,000 years ago and our bodies are still built for that. When you walk the dog, you may make new friends or even a date. If you go to the gym, you realize that your muscles work better and begin to make your body fitter. You will also feel better about yourself. You appreciate that your mood is lifting, and you feel the increased energy and strength.

Dr. Arash Javanbakht said about the bottom line:

“If we treated our body the way responsible dog owners treated their dog, we would live a much happier life.”

Live The Life That We Evolved For

Live The Life That We Evolved For

Conclusion

It takes people 1 million years for evolutionary changes. We do not change our behavior fast. Dr. Arash Javanbakht, an assistant professor of psychiatry at Wayne State University in Detroit, MI compared our lives now with the lives of the hunters/gatherers in the past. People ate fatty food, meat, vegetables, fruit, nuts and seeds when a prey was hunted. But then there was an episode of fasting. People then had to walk and run all day long to catch some food again or they had to run to escape from a predator. Nowadays we use cars for transportation, use the elevator to get upstairs and walk from the table at home to the TV set. If we do not move enough and we eat the wrong foods, we do not turn fit but we turn fat.

Our modern lives

We also use LED lights from TV’s, computers, iPhones and tablets that interfere with our diurnal hormone rhythm. It is not about going back to sending smoke signals, but it is all about setting limits and when to stop and disengage from social media and the phone. Not setting limits is part of why we have problems to sleep. Stress can also be a factor of insomnia. Dr. Javanbakht says that we need to relearn how our bodies were built. We need proper nutrition without high-energy carbs. In addition we need regular exercise that will help us to relax and feel more energy. Anxieties will lift and we will feel better about ourselves.

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Jan
19
2019

Alzheimer’s disease is treatable with hormones

Dr. Thierry Hertoghe, an endocrinologist from Belgium, stated that Alzheimer’s disease is treatable with hormones. This talk was part the 26th Anti-Aging Conference of the American Academy of Anti-Aging Medicine in Las Vegas (from December 13 to 15, 2018).

First of all, Dr. Hertoghe treated many Alzheimer’s patients himself and noted that they often have multiple hormone deficiencies. Secondly, common deficiencies affect thyroid hormones, human growth hormone, estradiol for women and testosterone for men. But even vasopressin and oxytocin are hormones that may be lacking. Third,  after doing thorough blood tests to assess hormone levels, Dr. Hertoghe replaced what hormones were missing. Finally, many Alzheimer’s patients got their energy, muscle strength and memory back.

In the following I am summarizing what Dr. Hertoghe told the audience about the various hormones. Alzheimer’s disease is treatable with hormones. Later I provide the hormone doses that Dr. Hertoghe uses for replacement.

Progressive memory loss

Generally, patients who develop Alzheimer’s disease start losing short-term memory first, but in time they will also lose long-term memory. Often this disease process starts in the 60’s as age-associated cognitive impairment. In the 70’s it may progress further to mild cognitive impairment, only to take off in the 80’s as Alzheimer’s disease. The astute clinician may order some screening blood tests in the 60’s and 70’s. In a male low testosterone, low DHEAS and low thyroid hormones may be present. Certainly, blood tests will show this readily. Frequently, in women low estradiol, low thyroid and low DHEAS may also be present. The reason this is important is that simple hormone replacement can return a person back to normal. Yes, this is right: hormone replacement can bring a person with age-associated cognitive impairment or mild cognitive impairment back to normal! In other words, Alzheimer’s disease is treatable with hormones.

Hormones important to monitor with Alzheimer’s disease

There are 6 hormones that are important for memory restoration in Alzheimer’s patients: IGF-1 (and growth hormone), thyroid hormones, estrogen and testosterone, vasopressin (and oxytocin) and pregnenolone. However, as Alzheimer’s patients often have sleep problems, another important hormone is melatonin.

Oxytocin to calm down aggressive Alzheimer’s patients

Notably, Dr. Hertoghe found that Alzheimer’s patients often are restless and can be aggressive. This makes it difficult to care for them in a home. Oxytocin is the hormone of trust, affection, sociability and concerns about others. It calms down aggressiveness. But with oxytocin treatment the Alzheimer’s patient feels better, becomes friendly, cooperative and warm-hearted.

As an illustration Dr. Hertoghe gave an example of one of his 80-year old patients with aggressive Alzheimer’s disease. She became unmanageable for her non-married son and other contacts. 5 IU of oxytocin sublingually changed this woman into a friendly, compassionate, warm-hearted woman, and the aggressiveness disappeared completely.

Insomnia in Alzheimer’s patients

About 45% of Alzheimer’s patients develop “sundowning”. When the sun goes down they start getting hyperactive, develop unacceptable behaviors and they become restless. Research papers showed that blood melatonin levels are low in these patients. Indeed, this is why they respond very well to small amounts of melatonin at bedtime. As a conclusion, within only a few days of starting this, their sundowning disappears, and they become easier to look after.

Dr. Hertoghe provided material from several research papers that showed that Alzheimer’s patients are often deficient for melatonin. Replacement with varying doses of melatonin solved even more complicated insomnia problems.

Melatonin is a powerful anti-oxidant. Interesting animal experiments have shown that melatonin has memory-enhancing properties. Researchers believe that melatonin improves the extracellular senile plaques with amyloid-beta peptide accumulation (first of 2 Alzheimer’s lesions). In addition melatonin also decreases the intracellular neurofibrillary degeneration tangles, the second of the two specific Alzheimer’s lesions.

IGF-1 and human growth hormone

Several studies have shown that Alzheimer’s patients have a significant drop in IGF-1 levels and growth hormone levels. This affects their short-term and long-term memory. Serum IGF-1 has an inverse correlation with cognitive impairment. Dr. Hertoghe said that IGF-1 treatment in Alzheimer’s patients increases their brain volume, increases the functional network of neurons in the brain and increases memory.

Brain atrophy in Alzheimer’s patients from chronically depleted IGF-1

Dr. Hertoghe showed a slide of a normal brain with a view from the outside and a cross section view of the brain. The same slide contained the view of an Alzheimer’s patient’s brain. It showed brain atrophy resulting in a much smaller brain and the cross section displayed an increase of the hollow spaces (e.g. the third and forth ventricle). He stressed that in his view the brain shrinkage of Alzheimer’s patients is due to prolonged low levels of IGF-1. This in turn is due to a lack of production of human growth hormone.

With IGF-1 treatment the serum IGF-1 was increasing and the cognitive function in older adults recovered. Dr. Hertoghe provided many literature citations to support this, which I will not repeat here.

Case report of a male patient with Alzheimer’s disease

Dr. Hertoghe presented one of his patients with Alzheimer’s. Lab tests showed that he had deficiencies of thyroid hormones, DHEA and testosterone. But despite replacement of these hormones he remained severely affected with Alzheimer’s. He did not remember his own name, could not go to the toilet on his own, spoke only a few words and suffered from severe fatigue. He received 4 injections around his eyes with IGF-1 and mesotherapy from his doctor (described below) with human growth hormone and IGF-1. Within a few weeks he had a complete reversal of his cognitive decline. He could return to his professional driving career doing halftime work with a delivery van in the city. He could read a newspaper and understood what he was reading. Alzheimer’s disease is treatable with hormones.

Thyroid hormones

According to Dr. Hertoghe thyroid hormones help to establish short-term and long-term memory and treat the apathetic depression in Alzheimer’s patients. Many Alzheimer’s patients are hypothyroid.With this deficiency they have swollen lower eyelids, a puffy face and paleness of the face. In a 1990 study a group of Alzheimer’s patients had 26% lower T3 levels when compared to normal controls. Many patients with hypothyroidism have memory loss, before their deficiency is corrected. Dr. Hertoghe stated that 13% of all dementia cases are reversible by proper thyroid hormone treatment.

Estradiol can improve long-term memory loss

Research showed that estradiol could improve long-term memory in dementia and Alzheimer’s disease cases. Many female Alzheimer’s patients are deficient in estrogens. If they do, they have dry eyes, a pale face and thin, dull hair. In a 2005 study 33 control women were compared to 48 women with Alzheimer’s disease. The estradiol levels in the Alzheimer’s disease group showed significant depletion compared to the normal control group. There was no significant difference found with regard to progesterone, testosterone and LH&HSH levels. Another study showed that in cerebrospinal fluid of women with Alzheimer’s disease the estradiol level was significantly reduced while the beta-amyloid levels were significantly increased.

Dr. Hertoghe reviewed several studies that showed that symptoms of Alzheimer’s disease disappeared with estradiol supplementation. Both memory and mood responded to the treatments.

Men with Alzheimer’s disease are often testosterone deficient

Testosterone is important for long-term memory. Men in andropause report erectile dysfunction, general weakness and memory loss. The physician needs to be aware that the patient may be starting to develop Alzheimer’s disease. Dr. Hertoghe showed a slide based on a publication, which stressed that testosterone enhances memory. It increases brain blood flow and thickens the myelin sheets. Testosterone increases dendrite and synapses and in addition decreases amyloid beta-peptide production. Neurotoxicity is also reduced. The end result is improvement of Alzheimer’s in males with testosterone replacement.

Pregnenolone improves short-term memory

Pregnenolone gets synthesized in the brain, spinal cord and peripheral nerves. Dr. Hertoghe said that pregnenolone is a neurostimulating “neurosteroid”. Pregnenolone concentrations in brain tissue are about 25- to 35-fold higher than in the blood stream. Some cases of Alzheimer’s disease can come from a lack of pregnenolone and pregnenolone sulfate. Patients who have Alzheimer’s because of a lack of pregnenolone have blood levels that are 2.5-fold lower than pregnenolone levels in normal controls. When these patients are treated with pregnenolone, their memory improves. The mechanism of the effect of pregnenolone is by increasing acetylcholine by more than 50% in the hippocampus. It also protects the hippocampus from glutamate and amyloid beta. Pregnenolone improves short-term memory over a period of 3 to 4 months of treatment.

Vasopressin improves short-term and long-term memory loss

Postmortem studies on Alzheimer’s patients showed that there is decreased vasopressin in the brain cortex. In patients with alcoholic dementia (Korsakoff psychosis after recovery) there was decreased vasopressin in the cerebrospinal fluid. Often patients with diabetes insipidus have decreased vasopressin and are in danger of developing dementia. If not treated, they develop short-term and long-term memory loss. When treated with vasopressin or Desmopressin their memory recovers within 4 hours of starting therapy. Younger patients (50 to 73) do better with memory recovery than older patients (74 to 91).

Treatment details of hormone replacement for Alzheimer’s disease

Before hormone treatments are given to a patient it is important to do a battery of blood tests. This will help the physician to identify the missing hormones in a particular patient. Each of the missing hormones are then administered separately.

Oxytocin

This hormone can be given sublingually or intranasally. Sublingually 5-10 IU are given daily. With the sublingual approach 1 or 2 sprays are given daily. Each spray contains 8 IU of oxytocin. Improvement is visible within 2 to 5 days. A full recovery takes 2 to 3 months.

Melatonin

Most patients in the higher age group do no longer produce their own melatonin. With the oral route 1-3 mg are given every night before going to bed. An alternative is to use sublingual tables 0.5mg to 1.0mg at bedtime. The first improvement can be seen 2-5 days after the start of replacing melatonin, the full impact takes about 2-3 months from the start of the treatment.

IGF-1 and human growth hormone

Replacement of IGF-1 can be done by injecting IGF-1 or human growth hormone (HGH). HGH stimulates the liver to produce IGF-1. IGF-1 is somewhat cheaper than HGH. When IGF-1 is used, 0.3mg to 1mg is injected at bedtime. Progress is slow; the first improvement is visible at 2-4 months, it takes up to 24 to 36 months for a full recovery.

For severe memory impairment with Alzheimer’s, the doctor does a double treatment approach with both IGF-1 and HGH: first subcutaneous IGF-1 injections around the eyes 4 times per day (0.01mg each). Secondly, at the doctor’s office the doctor administers mesotherapy injections with 1mg of HGH and 1mg of IGF-1 and vasodilators 3 times per week. Two weeks later the doctor administers another course of mesotherapy. He may repeat this twice in 14-day intervals. Now the interval increases to monthly therapy for 3 months and finally every 3 to 4 months. The patient can use IGF-1 nose drops instead of subcutaneous IGF-1 injections.

Thyroid hormones

Dr. Hertoghe prefers desiccated animal thyroid hormone replacement as the T3/T4 ratio is best matched to what the ratio is in humans. Depending on the severity of thyroid hormone deficiency the patient takes 30-150mg of thyroid hormone every morning. Dr. Hertoghe starts with a low dose and slowly increases the dosage. Clinical progress is very slow. It takes until the second month before the first improvement takes place. Full improvement can take 8-12 months.

Estradiol

Replacement of estradiol in postmenopausal women with Alzheimer’s disease received ether more than 0.1mg per day or 0.625mg of conjugated equine estrogen daily. In both cases there were improvements of their memory and improvement on the Hamilton depression scale.

Dr. Hertoghe’s preferred way to treat postmenopausal women with Alzheimer’s disease is as follows. The first 25 days of each month he gives them 1-2mg of oral estradiol valerate each day and 100mg of micronized progesterone. If they prefer an estrogen cream, he gives them 1-3mg per day transdermal estradiol and 100mg micronized progesterone capsules.

The first improvement is visible after 2-4 months; there is further improvement the next 8-12 months.

Testosterone

There are two methods of how to do hormone replacement with testosterone, either by injection or as transdermal cream. The injection treatment uses 250mg of testosterone enanthate or cypionate every 2 -3 weeks. The patinet can also self-administer testosterone enanthate (50mg twice per week) for a more even blood level of testosterone. The transdermal approach involves 100-250mg transdermal, nanoliposomal testosterone daily.

The memory will improve 2-4 months into replacement therapy. The full improvement takes 8-12 months.

Pregnenolone

The replacement therapy is 100mg per day in the morning for the first 4 months. Then there is a dosage reduction to 50mg daily. Studies have shown that 30mg of pregnenolone is not enough to treat memory loss. Short-term memory improved after 3 to 4 months in about 75% of patients.

Vasopressin

The best vasopressin preparation to use is bio-identical vasopressin. It comes as 1 nasal spray with 10IU of vasopressin. Upon awakening the patient or caregiver applies 1-2 sprays into the nose. The patient receives the second dose 10 minutes before lunch by nasal spray.

Apart from hormones, lifestyle changes are also recommendable.

Alzheimer’s disease is treatable with hormones

Alzheimer’s disease is treatable with hormones

Conclusion

Who would have thought that Alzheimer’s disease could have anything to do with hormones? Dr. Hertoghe, the endocrinologist from Belgium did many hormone tests on Alzheimer’s patients and concluded that various degrees of hormone deficiencies can indeed cause Alzheimer’s disease. But what is more is that you can replace the missing hormones and see complete cures in patients with Alzheimer’s disease. Alzheimer’s disease is treatable with hormones. This is something conventional medicine can only dream of. At this point this hormonal approach is not yet mainstream medicine; but it would not be a surprise to me, if in 10 or 20 years interested physicians do this type of therapy routinely in their practice. When hormones are missing, replace them. When the memory is fading, think about testing for missing hormones! It will make a difference in the quality of life for the patient as well as for his family.

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