Sleep More For Healthy Body Weight

Sleep deprivation is a common problem in a society governed by stress and hurry. Less hours of sleep may give us the illusion of being more effective, but it seems to be at the expense of our health. Lack of sleep affects our brain metabolism in various ways, and researchers at Columbia University recently examined data on 6115 people, ages 32 to 59 from a U.S. National Health and Nutrition Examination Survey. The findings were presented at a recent meeting of the North American Association for the Study of Obesity. Of those who slept less than four hours per night 73% were more likely to be obese. Those who slept six hours per night were 23% more likely to be obese. The findings further suggested that in people who sleep less than eight hours per night (about three quarter of the 1024 participants), body mass index was inversely proportional to sleep duration.

The researchers also reported the reasons for that. Sleep deprivation lowers leptin, a blood protein that suppresses appetite and sends the signal, when the body had enough food. Lack of sleep also raises ghrelin levels, a polypeptide hormone from the stomach wall, which makes people want to eat. Laboratory tests of one study showed that making do with only four hours of sleep resulted in an 18% reduction of the leptin (the “appetite stopper”) and a 28% increase of the ghrelin (the “appetite animator”). Translated into plain text, it means that the breaks were removed and the signal given to eat by 46% more than in persons with a sufficient dose of sleep.

Increase of obesity risk due to sleep deprivation

obesity risk with sleep deprivation

Obesity risk with sleep deprivation

In addition sleep deprived healthy persons in their 20’s also craved more sweets and starchy foods than well-rested individuals and these added calories are stored as body fat. These hormonal changes are the biochemical evidence pointing to the connection of a sleep-deprived lifestyle with obesity and the associated health problems like diabetes and cardiovascular illness.
Drastic diets don’t seem to hold the answer. Part of the entire picture may be as simple as sleeping more and as a result weighing less.

Reference: The Medical Post, February 1, 2005,page 17

Last edited December 7, 2012


Poor Lungs And Heart Attacks Related To Leptin Levels

It is known from the medical literature that poor lung function can often lead to heart attacks making it one of the important causes of premature death for patients with poor lungs (due to emphysema, chronic bronchitis, COPD etc.).

A research team led by Dr. Don Sin from the University of Alberta, Edmonton, Canada, asked the question recently whether there may be a circulating factor that would be responsible for this association of poor lung function and increased cardiovascular disease.

They studied serum leptin and a variety of other inflammatory markers such as C reactive protein, leukocytes, and fibrinogen in 2808 participants in the Third National Health, Nutrition, and Examination Survey. Apart from blood tests they also measured lung function by spirometry (forced expiratory volume in 1 second, called FEV1). The leptin levels found in these patients were then divided into 5 groups from low to high levels. They also carefully adjusted the data for body mass index, sex, age and other factors. They compared the group with the lowest leptin concentration (lowest quintile) with the highest group of leptin concentration (highest quintile) and looked for any significant differences in any of the markers.

Results: The highest quintile group (high leptin in blood samples) had also the highest other inflammatory markers in their blood (C-reactive protein, leukocytes and fibrinogen). This group was the one that was associated with advanced lung diseases as well as heart disease. The authors of this study, which was recently published in a medical journal (Thorax 2003;58:695-698), concluded that leptin plays an important role, if not the major role, in the development of both chronic lung disease and cardiovascular complications.

Poor Lungs And Heart Attacks Related To Leptin Levels

Poor Lungs And Heart Attacks Related To Leptin Levels

Links to lung disease:
Links to heart attacks:

Last edited December 9, 2012