Aug
31
2013

Peanut Allergies Are Deadly

In the US 1.5 million suffer from peanut allergies (Ref.1). People who have peanut allergies have to avoid peanuts and foods that contain even traces of peanuts lifelong. Here is a recent example of a 13-year old girl who died at a camp when she tried food contaminated with peanuts. Before we discuss peanut allergies in detail, we need to review first how the immune system is functioning.

How the immune system is primed to develop an allergy

Our immune system knows the difference between our own body components and substances that come from the outside. Scientists call this tolerance to our own surface proteins; and scientists call it an immune reaction that is mounting as a reaction to anything different from the surface antigens. There are different cells that make up the immune system. One of the main working cells of the immune system are the lymphocytes, with B cells originating from the bone marrow producing antibodies when an immune reaction occurs. Antibodies fit like a lock and key to the surface of an antigen, in this case the peanut protein. T helper cells are T lymphocytes (thymus derived lymphocytes) that help the B cells to recognize the difference between the own protein components and the outside components. There are also T killer cells, which get activated when parasites or viruses enter the body. With regard to peanut allergies it is the B cells and T helper cells that interact and the B cells produce a powerful, very specific IgE antibody directed against peanut protein. There are memory B cells, which continue to produce these specific anti-peanut protein antibodies and cause severe allergic reactions when future exposure to peanuts (even traces) occurs. So, the more often a person who is allergic to peanuts encounters even traces of peanuts, the immune system will get boosted and produce even more antibodies of the IgE type through reactivated B memory cells (Ref. 2). 98% of the population does not react to peanut exposure with allergies, but the other 2% who may have genetic susceptibility factors that predispose them to this often develop life-threatening reactions (an anaphylactic reaction).

What is an anaphylactic reaction to peanuts?

The most extreme form of allergies involving IgE antibodies can cause anaphylaxis. In the beginning stages of a peanut allergy there may only mild symptoms such as hives on the skin, itching and tingling around the mouth, a runny nose, a scratchy throat, wheezing, stomach cramps, vomiting or diarrhea. However, with a more severe allergy an asthma attack can develop, blood pressure drops leading to fainting or shock and severe airway obstruction in the throat or lungs can cause suffocation.

I vividly remember an 11-year-old boy who was brought in by ambulance to the emergency room of the hospital where I was working as the on-call physician. He had a hard time talking as his throat was swelling up as part of his anaphylactic reaction, within minutes he passed out completely (shock). Fortunately an anesthetist was in the department and could intubate him very quickly. However, despite adrenaline treatment, oxygen  by artificial ventilation and high doses of corticosteroid drugs he did not wake up until 10 hours later. In retrospect it turned out that he had eaten some crackers of a familiar brand that he knew as being free of peanut flour. However, he had seen an ad that the same brand of crackers was available as cheese crackers and he tried one of these, which prompted his admission to the hospital. The parents read the ingredients later: the label on the cheese crackers noted in small print that the flour of the cheese crackers contained peanut flour! Always read labels, even if it is a familiar brand! Fortunately for this boy he did not have brain damage from the time of his unconsciousness. He has been extremely careful since and is reading labels and avoiding unknown food items.

Peanut Allergies Are Deadly

Peanut Allergies Are Deadly

Cross-reactions between peanuts and other allergens

Allergies can be made worse when a person has inhalant allergies from pollens of trees or grasses that can share protein components from protein found in foods. The latest findings are that there are cross allergies between Fenugreek and lupine, which are both legumes, as are peanuts, so there are common antigens present in their proteins. A mouse-testing model has shed more light on this. Fenugreek has been shown to control mild diabetes by improving insulin resistance, but it cannot be consumed by persons who are highly allergic to peanuts because of the cross allergy mentioned.

There are other possible cross allergies to legumes like lentils, soy and chickpeas.

Other factors that can cause allergies to get worse

In the past the RAST test was often used.  This is a blood test for common food allergies that can cause severe allergic reactions like egg, milk, peanut, tree nuts, wheat, crustacean shellfish and soy. However, since about 2010 this has been replaced by the more sensitive ImmunoCAP Specific IgE test. Children who have food allergies to egg, milk, wheat, nuts, peanuts and soy often outgrow these allergies when they age, in other words their immune system can develop tolerance to many of these foods. Not so with peanut allergies ! They tend to be very persistent.

The immune responses to food allergies are complicated as there are immediate type immune reactions and delayed type immune reactions. The immediate immune responses are investigated with the above mentioned ImmunoCAP Specific IgE test. The delayed immune responses can be measured using the ELISA test. Positive IgE antibody tests for peanut protein are a marker that the person affected likely has more other allergies and they should be investigated by a knowledgeable allergist in that regard (Ref. 2).

What complicates the allergy sufferers’ lives even more is the fact that new wheat varieties since the 1970’s, called Clearfield wheat have a much higher gliadin (gluten) and lectin content than the old wheat varieties. As a result of exposure to this new type of wheat gluten intolerance and leaky gut syndrome have increased substantially in the world population (Ref.3). In addition, genetically modified foods like soy, corn, sugar beets, canola and others have challenged the immune system of sensitive humans even more. We do know that some people can develop autoimmune diseases from GMO foods and modern wheat, and this may be the reason that a host of diseases that belong into this disease category (MS, rheumatoid arthritis, Hashimoto’s thyroiditis, ankylosing spondylitis etc.) are much more common now than in the past. The geneticists who developed GMO foods seemed to be unaware how sensitive the immune system is, which will detect a few different amino acid sequences in a protein mounting a strong immune response to it.

Treatment for peanut allergies

The key for sufferers from peanut allergies is to avoid exposure to it. Read labels and use common sense. If something is not labeled, do not be tempted to eat it. Peanut flour is often mixed into the dough of crackers, not being labeled properly or only in fine print. With peanuts the antibodies usually circulate in the blood life long as the B memory cells do not diminish and get reactivated very quickly on repeat exposure producing antibodies again. As exposure to peanuts can cause severe asthma or anaphylactic shock, it is important to carry an EpiPen with you and to know how to use it.

In Europe attempts have been made to develop an oral desensitization method for food allergies including peanut allergies, but it has not produced concrete results yet. Recently, however, research from Texas, USA showed that it is possible to desensitize patients with peanut allergy by oral desensitization. In Australia where food allergies are more prevalent than in the US, tolerance to peanut, nut and shellfish allergies is being pursued by oral immunotherapy. Another group in Australia has developed a vaccination method using peptides, which are a sequence of amino acids, but shorter than the full peanut protein. It appears that this is the future direction of  treatment for peanut and other IgE mediated allergies: a kind of vaccination treatment to induce competing antibodies, which will neutralize the allergic IgE antibodies.

Conclusion

Peanut allergies have become more troublesome as the food industry has mixed peanut flour into Thai sauces, drinks, cookies, crackers and such. The person allergic to peanuts must read food labels and eat as much single-ingredient natural food as possible. This goes against the tendency of food processors who produce foods with a long rat tale of ingredients. If you see a label “may contain nuts or peanuts”, stay away from this product, as it is safer. Always carry an EpiPen or Twinject with you, just in case you develop an anaphylactic reaction (you only have a few minutes to stop the allergic reaction with adrenaline). In the future vaccination with a peanut protein specific peptide vaccine as mentioned regarding the Australian research, will probably become the treatment of choice.

More information on status asthmaticus (an acute asthma attack): http://nethealthbook.com/lung-disease/asthma-introduction/asthma-treatment/

References

1. Adkinson: Middleton’s Allergy: Principles and Practice, 7th ed. Chapter: Food Allergy. © 2008 Mosby.

2. Mandell: Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th ed.© 2009 Churchill Livingstone.

3. William Davis, MD: “Wheat Belly Cookbook. 150 Recipes to Help You Lose the Wheat, Lose the Weight, and Find Your Path Back to Health”. HarperCollins Publishers LTD., Toronto, Canada, 2012.

Last edited Nov. 7, 2014

Aug
03
2013

Treating Symptoms Not Effective, Find And Eradicate Causes

When you see a physician about a health problem, he or she general listens to your symptoms, examines you, comes to a diagnosis and then treats the symptoms. Medicine has been evolving since, anti-aging medicine has become more prominent and comprehensive medical practitioners have started to treat differently. The changing approach is best explained with some examples below. This is important as many general practitioners continue to treat symptoms and neglect to search for causes. Big Pharma is trying to keep the medical system in the “status quo” (the way it is), because they make big money by having general practitioners try out different ineffective medications (this way the profits keep on coming in.) One example is the cholesterol story. Only 50% of heart attacks are caused by high cholesterol, but physicians keep on prescribing statins whenever high cholesterol is found to prevent a heart attack. But the finding of high cholesterol could be caused by hypothyroidism (when the thyroid gland does not produce enough thyroid hormone). Diet can also play  a role, if the patient eats too many helpings of fatty meats and drinks alcohol regularly. Just prescribing statins to lower cholesterol is not the answer, treating the cause is!

I am going to describe 5 examples where usually symptoms are being treated instead of the causes. If you are in a hurry, just read example 3 below (gastritis and duodenal ulcer). After that you can skip forward and read the conclusion, where I will summarize what I think we should learn from this.

Treating Symptoms Not Effective, Find And Eradicate Causes

Treating Symptoms Not Effective, Find And Eradicate Causes

1)  Rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease where autoantibodies attack the joint surfaces. It is a multifaceted disease and typically requires a rheumatologist to get involved in the treatment. The standard treatment for RA is summarized in this link. Before engaging in these toxic treatments, it is very worthwhile to study this link and see, if any of your food components may have triggered your arthritis. Various agents in the food can contribute to the development of autoantibodies, such as wheat, soy, MSG, even salicylates. An elimination diet approach could pinpoint if there is any food component that may be the cause of your RA.

Dr.Lichten, in treating many RA cases has found (Ref.1, p. 85 and 86) that many patients had hormonal deficiencies, particularly a lack of DHEA when blood tests were done for this. DHEA is known to treat immune deficiencies and T cell responses were observed to raise 10-fold after DHEA supplementation; IGF-1 levels (an indirect measure of human growth hormone) increased and muscle mass improved when exercised as well along with DHEA replacement. RA patients responded well to relatively low doses of DHEA (25 mg daily for women and 50 mg daily for males). When other hormone tests are done to look for deficiencies, Dr. Lichten found sometimes thyroid deficiencies requiring hormone supplementation. Similarly when saliva tests are done to look for sex hormone deficiencies, there may be progesterone and/or estrogen deficiency in women and testosterone deficiency in males that needs to be replaced with bioidentical hormones. In RA patients there may be adrenal gland deficiency setting in, which can be diagnosed by a four-point saliva cortisol hormone test. Only these cases of true hormone deficiency will benefit from small doses of cortisol (the original bioidentical human hormone) given four times per day.

Here is a summary of the usual recommendations for home remedies for treating rheumatoid arthritis. Using electro acupuncture can be very useful for controlling chronic pain, but you still need to work out the cause for your particular case of RA.

2) High Blood Pressure

Most cases of high blood pressure (hypertension) are simply there without a particular cause. It used to be called “essential hypertension”, a fancy name meaning “essentially, we do not know the cause”. The doctor will start treatment with drugs to bring high blood pressure down. Before that the doctor is supposed to ask you to make a good effort to change your life style (cutting out additional salt, exercising, weight loss), but this is often glossed over and drugs are used right away. Drugs for hypertension are not harmless; here are some of the side effects.

The medical textbooks are not very clear on what causes high blood pressure. With renal causes (narrowing of a renal artery) a stent can be placed, the cause is treated and the blood pressure normalizes. As indicated, essential hypertension is the name for the majority of other cases of high blood pressure where officially no cause is known. Patients are usually put on life-long antihypertensive medications, often several drugs in combination, to bring the blood pressure down to 120 over 80.

Despite the notion that we do no know the cause of high blood pressure, we do know that a number of factors can contribute to developing high blood pressure: too much salt in the diet, too much nicotine from smoking and too much alcohol consumption.

A lack of nitrates from green vegetables can cause high blood pressure as well. Nitrates are necessary for the body to produce nitric oxide, a powerful messenger that dilates blood vessels lowering blood pressure. It is produced every second by the lining inside the walls of your arteries. Greens and vegetables, particularly beets, provide nitrates for nitric oxide production.

Nitric oxide, along with omega-3-fatty acid and prostaglandins are important in relaxing the arterial walls, thus lowering high blood pressure.

We also know that in diabetes and obesity high blood pressure is very common, because inflammatory substances circulate in the blood, which interfere with the normal production of the blood pressure lowering nitric oxide.

Treating high blood pressure with the conventional drugs will mask the real underlying causes.

The DASH diet has helped a lot of people to get their blood pressure under control. However, the limiting point in that diet is the amount of grains that are allowed. In my opinion, wheat and grains, starches and sugar are all empty calories and only stimulate your appetite because of the high leptin and gliadin content from wheat and wheat products. According to the cardiologist, Dr. William Davis, cutting these out will cure not only many cases of hypertension, but also diabetes and obesity. Many physicians have criticized him, but in my opinion his work is on solid researched ground. If a patient honestly gives lifestyle changes a try, many side effects and deaths from antihypertensive drugs could be avoided.

3) Gastritis and duodenal ulcer

You see your doctor, because lately you regurgitate acidy stomach contents. You may be diagnosed with gastritis and get a prescription for an acid suppressive drug. But before you take proton pump inhibitors (PPI) study the side effects here.

The interesting part is that many chronic gastritis cases are associated with a bacterium called H. pylori. Unfortunately it is now known that cimetidine, ranitidine and particularly PPI’s are treating the acid problem (the symptomatic treatment of acid suppression seems to work), but on the longer term they encourage H. pylori to grow more, particularly in the stomach. The bacterium undermines the lining of the stomach and the duodenum and interferes with the production of the protective mucous production, which is meant to protect you from gastritis and ulcers. Dr. Murray explains that the cause of gastritis, gastric ulcer and duodenal ulcer is the breakdown of the mucosal barrier (Ref. 3, p.73-75). So the symptomatic treatment of the H. pylori infection with triple therapy (2 antibiotics and a PPI) may be the medical treatment commonly accepted as the norm, but it does not cure H. pylori in many cases. Some patients develop diarrhea from a Clostridium difficile super infection as a result of the antibiotics from the triple therapy requiring even more expensive antibiotics for that condition. This only happened, because the patients’ symptoms were treated instead of the cause. The cause of gastritis and duodenal ulcers is a weakening of the lining in the stomach and the duodenum resulting in a breakdown of the mucous barrier. In some people dietary habits play a role, like too much cereal and wheat consumption with too little alkaline vegetables in the meals to neutralize the acid formation (see Ref. 2 for more details). However, when a simple licorice compound (DGL, which stands for deglycyrrhizinated licorice) is given, the symptoms from gastritis, acid reflux, and ulcers in the stomach or duodenum disappear. DGL supports the lining of the stomach and duodenum and reestablishes the defense against the acidy milieu. Not only that, but after a few weeks of DGL treatment all of the findings on endoscopy such as inflammation and ulcerations disappeared. Dr. Murray states that he has not encountered a case of gastritis or ulcer that would not have responded. It appears that the cause of gastritis and ulcers in the stomach and duodenum is not from too much acid, not from H. pylori infection, which appears to just be a concomitant infection, but actually is due to a breakdown of the barrier in the lining of the stomach and duodenum, which responds to DGL. The other interesting thing is that you can buy DGL in the health food store; the dosage is two to three chewable tablets on an empty stomach three times per day. According to Ref. 3 it needs to be taken 8 to 16 weeks, after which there is a full therapeutic response. Pepto-Bismol is another coating substance that is available over the counter and works well for minor stomach upsets.

4) Chronic back pains and insomnia

Many people see their chiropractor for chronic recurrent back pains and their physician for insomnia to get sleeping pills. It all depends what the underlying causes are of back pains and insomnia.

If there is a misalignment in the spine, a chiropractor doing manipulation would be a reasonable approach and the back pain symptoms often disappear. However, thyroid deficiency or adrenal gland insufficiency or adrenal gland fatigue may be the cause of back pains and muscle cramps. Unless the underlying cause is treated (in the case of hypothyroidism treatment with thyroid hormones), the back pains will stay. In fibromyalgia where muscle pains are all over the body, the standard treatment with antidepressants and pain pills just will not do it on the long-term. These patients require a detailed work-up with analysis of the hormonal status. Often they are suffering from a lack of thyroid hormones, a lack of sex hormones (in women a lack of estrogen and progesterone, in men a lack of DHEA and/or testosterone). But they may also have weak adrenal glands and a lack of growth hormone. An anti-aging physician (A4M) can order the appropriate tests and treat the underlying causes.

Fibromyalgia patients often have insomnia (sleep disorders). Dr. Lichten (Ref.4) recommends GABA in small doses (125mg to 250 mg) at bedtime along with 500 mg of L-tryptophan. He also recommends 4000 IU – 5000 IU of vitamin D3 (as often insomnia patients are deficient in vitamin D3) as well as 500 mg to 1000 mg of magnesium. If this alone is not sufficient, melatonin, 1 mg to 3 mg at bedtime will be beneficial. Dr. Lichten cautions that GABA leads to tolerance quickly, so it should only be taken 5 days out of 7 to allow the body’s receptors to recover. This alternative approach to treating insomnia will prevent many patients from getting addicted to sleeping pills (hypnotics).

5) Asthma symptoms

Not every case of asthma needs steroid inhalers and salbutamol or other bronchodilator inhalers as treatment. This link shows that low thyroid can also cause asthmatic symptoms of wheezing and shortness of breath. It is important to listen to the patient’s symptoms, but the treatment will only be successful when the cause is treated. Dr. David Derry described in this link how many of his severe asthma patients had iodine deficiency and low thyroid hormones and no longer had to see him when iodine treatment and desiccated thyroid hormone replacement was given as treatment. This goes against what the standard recommendation for asthma treatment is, but it seems to get patients unhooked from dependence on steroid inhalers.

Steroid dependency from anti-asthmatic inhalers can suppress the adrenal glands and lead to adrenal gland insufficiency.

The adrenal glands are vital for coping with stress as the more stress you are under, the more your pituitary gland produces ACTH hormone, which in turn stimulates the adrenal glands to produce cortisol. However, a significant percentage of patients with asthma that been on corticosteroid inhalers for a long time, experience a suppression of the pituitary gland and the adrenal glands cannot produce the required stress hormones; in other words, adrenal fatigue or adrenal insufficiency can set in.

This is an example where during the treatment of asthma symptoms were controlled with corticosteroid inhalers, but the stress hormone circuit was undermined to the point where the patient experienced another disease (called a “iatrogenic disease”, a disease from the side-effects of drugs). Treatment of adrenal fatigue is described in this link.

Conclusion

Medicine can become quite complex as these examples show. Many times physicians tell their patients that the cause of their symptoms is not known. However, this is not always true, but conventional medicine continues to hold onto the old dogmas. With the third example above (gastritis and duodenal ulcer), until the mid 1980’s the original theory in medicine was that too much acid production would be the cause of these conditions and treatment concentrated on suppressing acid production. Then the new theory came up that H. pylori, a bacterium would be the cause of chronic inflammation, which together with too much acid would cause the condition. That is why physicians now treat it with the triple therapy, a good deal for Big Pharma, but a bad deal for many patients. They still do not get cured, but develop a worsening of their conditions as H. pylori growth proliferates, particularly from the PPI’s, which undermines the lining of the whole stomach. As pointed out above DGL, a simple licorice compound, which is available in health food stores, can strengthen the lining of the stomach and duodenum, which at the same time gets rid of the H. pylori problem without any other drugs.

The problem with conventional medicine is that in many cases physicians still treat symptoms instead of treating known causes. Big Pharma supports this, as it is expedient for them to protect their multi billion-dollar industry. Patients need to demand that the causes of their diseases are being treated rather than the symptoms.

References

1. Dr. Edward M. Lichten: Textbook of bio-identical hormones. ©2007 Foundation for Anti-Aging Research, Birmingham, Michigan, USA

2. William Davis, MD: “Wheat belly. Lose the wheat, lose the weight, and find your path back to health.” HarperCollins Publishers Ltd., 2011.

3. Michael T. Murray, ND: “What the drug companies won’t tell you and your doctor doesn’t know”. Atria Books, New York, 2009.

4. Dr. Edward M. Lichten: Textbook of bio-identical hormones. ©2007 Foundation for Anti-Aging Research, Birmingham, Michigan, USA

Last edited Aug. 3, 2013

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Jul
20
2013

Our Endangered Food

Our grandparents were eating foods that were healthier and more pure than today’s mass produced food. Beef came from grass-fed cattle; milk came from cows that grazed on pastures; bread was baked from the old Emmer wheat or Einkorn wheat. Geneticists were not around yet, so their food was safe from adulteration.

The adulterated modern wheat

Fast forward to the late 1990’s. Now farmers around the world are growing 19 different Clearfield wheat varieties that were produced by hybridization from exposure to toxic chemicals in the 1960’s and 1970’s when GMO (genetically modified organisms) regulations were not around yet.  Modern wheat was produced by hybridization with grasses using exposure to a toxic substance, sodium azide. Technically this forced chemical hybridization is different from genetic engineering although in both cases there are significant genetic changes of the chromosomes in the plant. The end result with regard to wheat hybridizations were wheat varieties that grow under adverse conditions and that have much faster growing rates, higher yields and are easier to harvest because they grow only to a about 2 feet height instead of 4 feet.  When compared to the older Emmer and Einkorn types of wheat there have been significant chromosomal changes. Einkorn (Triticum monoccocum) has 14 chromosomes; Emmer (Triticum diccocum) has 28 chromosomes. Modern wheat, the Clearfield variety has 42 chromosomes, like spelt. The hybridization process for Clearfield wheat by BASF is summarized in this link. Here is a discussion with Dr. Davis, the author of the book “Wheat Belly” (Ref.1), which reviews the history of modern wheat

The point of mentioning all this here is that modern wheat with many more chromosomes than the original Einkorn wheat has also much more gliadin content, which is the protein that makes celiac disease sufferers sick when they eat wheat. However, despite the significant chromosomal changes of modern wheat, which his grown in 99% of the world today no safety experiments were done to show that it is harmless to your health. There were no animal experiments and no human exposure trials with proper controls to show that it is safe to be exposed to the modern wheat varieties on the long-term.

It turns out now in hindsight that it is not only the person with celiac disease that has to fear modern wheat. The increased concentration of gliadin in modern wheat is the protein that splits the sealant between gut cells and sensitizes your body to produce autoantibodies. The food processing plants mix wheat into soups, baby food, lip stick, sauces and a host of other processed foods,which increases the concentration of gliadin that you are exposed to, if you do not eliminate it. You have to be a detective in the supermarket and constantly read labels to look for wheat and avoid it, at least I do. The reason is that even low doses of wheat over a long period of time cause leaky gut syndrome and cause antibodies against gliadin. Soon after autoimmune antibodies against your own tissues are formed that will attack your gut cells (causing irritable bowel syndrome, celiac disease and ulcerative colitis); joint cells (causing rheumatoid arthritis), thyroid cells (causing Hashimoto disease) and it can even cause colon cancer.

Remember, there have never been any clinical trials to show that modern wheat is safe.

Our Endangered Food

Our Endangered Food

Alternatives to wheat

Oats used to be thought safe to eat for celiac disease patients, provided they are not contaminated with rye, wheat or barley.

As this publication shows there can still be prolamins in oats, which are different from gliadin, but may be toxic for celiac patients. Another paper showed that there are different levels of gliadin- and glutenin-like avenins in different varieties of oats. These are subunits of prolamin. Depending on what type of avenins or prolamins are contained in an oat variety, the oat brand could be entirely gluten free, but the question is whether the manufacturer tested this before it reached the shelves of the grocery store. For a celiac patient it would not be safe to eat these types of oats as labeling requirements for avenins or prolamins do not yet exist. So the label “gluten free oats” may be misleading as oats containing prolamins or avenins still could make celiac patients sick.

So, what are safe gluten substitutes? Rice, corn, soy, chickpeas, sweet potatoes and nuts. A helpful reference can be found through this link.

As we will discover below, unfortunately in the US most rice, corn and soy is now GMO food and celiac patients will likely react much more to these as they are more sensitive and will likely produce autoantibodies easier. So stick to organic rice, organic corn and organic soy (often the package will mention ”free of GMO”).

GMO foods to avoid

It is interesting that no law was passed so far in the US and in Canada that GMO foods should be labeled. This is changing rapidly as people realize that in Europe many countries have required all GMO foods to be labeled as such. Here is a publication that shows that the GMO labeling campaign is gaining momentum.

Genetically modified corn and soy contains the Bt toxin; it has been found in babies as mentioned in this article. Bt toxin damages the small bowel (the ileum) through Cry1Ab (the protein produced in genetically modified corn and soy), which disables the absorption of vitamin B12. This in turn will cause anemia (historically the cause of pernicious anemia was found to be due to a lack of vitamin B12 absorption).

Drs. Anthony Samsel and Stephanie Seneff  stated about the effects of Roundup in a publication dated April 2013  that glyphosate’s inhibition of cytochrome P450 (CYP) enzymes, which is a crucial detoxification enzyme complex in the liver has been overlooked when studies were done regarding toxicity in mammals. The CYP enzymes in the liver is important to metabolize and eliminate estrogens and also helps to detoxify xenobiotics, which are estrogen-like substances as residues from insecticides and other chemicals. Thus, glyphosate (=”Roundup” produced by Monsanto) amplifies the damaging effect of environmental toxins and chemical residues from non-organic food that we eat. The build-up of estrogens and xenoestrogens has been shown to be responsible for many cancers (atypical Hodgkins lymphoma, breast cancer, prostate cancer, colon cancer etc.).

Here is a summary of the 10 most common GM foods in the US : Sugar beets, potatoes, corn, tomatoes, squash, golden rice, soybeans, soybean oils, animal feed, salmon. You see that almost all of our foods are being invaded by genetic engineering.

Why is that of any concern?

The problem is that it is extremely difficult to conduct safety studies for human consumption. It likely takes three generations of feeding GMO food before diseases develop and in the case of humans where the reproductive cycle is 30 years this would mean that it could take up to 90 years to obtain meaningful human safety study results. From a commercial point of view this is perceived as too long, so the standard rat or mouse model of testing for 90 days was introduced, which is used instead as a “test for toxicity for mammals”, but typically this does not show any change between GMO food compared to regular food (as it is too short an observation time). I have described this earlier in this blog. In this recent publication pigs fed GM crops were found to have severe stomach inflammation and the female GM fed pigs developed a 25% larger uterus than the non-GM-fed controls. The 20-year approval process for GMO foods is flawed according to this review. It states that Belgium researchers found virus particles in GMO foods that were not assumed to be present, but never tested for. This is fed in feedlots to milk producing animals and beef cows and gets transmitted into milk and beef. The FDA, USDA and other official food safety agencies continue to state that GMO foods are safe. As outlined in the beginning of this blog a significant proportion of the US public disagrees about the safety of GMO foods and wants all GMO to be clearly labeled. We should have a choice whether we get organic food with no chemicals, no antibiotics and no GMO in it or whether we buy the cheaper regular food.

You are what you eat.

Conclusion

Originally wheat was modified by hybridization to safe the world from hunger. The production worldwide has improved tremendously so that this objective has been reached. However, since then genetic engineers have worked on adulterating the rest of our foods mostly with the aim to make farming on a large scale easier. In both instances safety testing on animals and humans was never properly done, and it is only now that it is becoming apparent that there are flaws with regard to food safety both in wheat and with GMO foods. With wheat it is the higher concentration of gluten and gluten-like substances that cause a leaky gut, a breakdown of the gut/blood barrier and cause autoimmunity and colon cancer. GMO foods may transmit viral particles and Bt toxin, which can cause autoimmune diseases and fertility problems as well as interference with the liver’s detoxification system, which causes cancers. The full health impact is not clear at this point and it may take another 70 years for wheat and another 80 years for GMO foods to find out all the consequences. Some people have decided not to be part of this mass experiment and rather buy organic foods. I belong to this group.

More information on genetically modified food: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/genetically-engineered-foods/

Reference:

1. William Davis, MD: “Wheat belly. Lose the wheat, lose the weight, and find your path back to health.” HarperCollins Publishers Ltd., 2011.

Last edited Nov. 24, 2014

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Apr
14
2013

Allergies Not Only In Spring

Springtime is the time of spring allergies: those affected develop a runny nose, itchy eyes and in more severe cases they may experience a flare-up of asthma. Allergies can be triggered by the increase of pollen counts in the air that occurs every spring. In those who are sensitive, this leads to antibody formation in the blood. But often people have not only sensitivities to the pollens of spring bloomers; they may also be allergic to spores from molds, to dust mites and may have underlying allergies to foods. The immune system has memory cells that memorize that a person has had an allergic encounter to one of these items in the past, and allergic reactions can become more significant with a future encounter. Allergies can also be made worse when a person has food sensitivities and there are cross reactions between pollens of trees or grasses that can share surface protein regions with similar protein regions in foods.

It is known that cross allergies are possible between birch pollen and apple, carrots or hazelnut. In its extreme form allergies due to antibodies, called IgE antibodies, can cause anaphylaxis. A person presensitized by inhaling birch pollen, after eating an apple, hazelnuts or a carrot can develop itching of the throat, swelling of the lips and very quickly deteriorate getting into an anaphylactic shock.

Other cross allergies exist between ragweed pollen, which is a powerful inhalant allergen and melons or bananas. Again there are specific IgE antibodies that are responsible for this immune reaction. In this case the ragweed allergy primes the immune system to produce IgE antibodies, which are potentiated by certain foods that share similar protein components as the ragweed pollen.

In the following I will deal with inhalant allergies separately from food allergies.

Allergies Not Only In Spring

Allergies Not Only In Spring

Inhalant allergies

Inhalant allergies are easier to diagnose and to treat than food allergies. Your doctor will likely refer you to an allergist when you have allergies that do not respond to treatment with intermittent over the counter antihistamines. Your symptoms may come on in the spring with itchy eyes and a runny nose. From year to year you find that you become more and more dependent on antihistamines and nose drops to unplug your nose. The allergist likely will do sensitivity tests, which consist of skin prick or scratch tests on the back or the forearms.

In more serious allergies, where the patient has coughing and wheezing attacks following allergic reactions, the allergist may suggest to start intermittent allergy injections alongside the standard inhalation therapy for asthma. An allergy serum is prescribed where the lab mixes ingredients based on all of the positive tests that led to a strongly positive skin reactions when allergy testing was done. Typically the family doctor or his nurse will start the allergy injections initially in weekly intervals, later when the maintenance dose is reached, it may be modified to injections every 10 to 14 days.

The allergy injections stimulate the immune system to produce harmless competing antibodies, which counteract the disease producing allergic antibodies. In the process of desensitization shots the immune system will normalize, which means that the inflammatory response of the immune system settles down to normal.

This is not the end of the story with inhalant allergies. The patient needs to be retested on a yearly basis by the allergist. The immune system changes all the time as new allergies can develop and old ones may go away.

Retesting is necessary to keep track of what is going on and to change the composition of the allergy serum. Those patients who are working together with the allergist can do very well, and often they gradually outgrow their allergies. Others may not be so lucky. They may have reactions to the allergy injections. In these cases avoidance of what causes the allergy may be the only solution to treat the allergies.

There is an alternative to allergy injections, which has been used in Europe, namely a sublingual immunotherapy. Recently there has been a review of the literature for FDA approval that is needed for oral desensitization for ragweed, dust mites, grass pollen and cat dander. It will take some time before the FDA approval process will become a reality for sublingual desensitization in the US.

A special form of inhalant allergies are allergies to pets (mainly dogs and cats, but also allergies to petting zoo animals). The dander that the human comes in contact with is a protein contained in the animal hair. It causes hives when it touches the skin. This occurs as the dander is absorbed through the skin and meets the local mast cells that release histamine. This in turn is responsible for the hive formation. Sneezing and even asthma can develop from inhaled protein particles that reach the lungs. Allergy injections for the treatment of animal dander allergies are very limited as they often do not help or make the allergies worse. Avoidance of animal contact is usually what the allergist recommends as the solution, a recommendation, which often is not appreciated by the affected animal lover.

Food allergies

Often we eat  some foods more frequently, because they are our favorites. This means that our gut lymphocytes that get in contact with these foods can start to react to one or more of the foods we ingest. At this time we may experience abdominal cramps, diarrhea, vomiting and a host of other possible symptoms.

The physician will tell the patient that testing for food allergies is a problem as most of the usual skin tests employed for inhalant allergies do not reliably work in determining food allergies. The doctor will ask the patient or the mother of the child with food allergies to keep a food diary and keep track of the allergic symptoms in the diary as well. An elimination diet will have to be devised based on the information gathered in the diary as it becomes clear from that record which foods cause which symptoms. The foods causing allergic symptoms are subsequently eliminated. This is a cumbersome process, but it is the most reliable method of testing and treating food allergies.

In the past there was a blood tests, called RAST test, which tested for common food allergies that can cause severe allergic reactions like egg, milk, peanut, tree nuts, wheat, crustacean shellfish and soy. Since about 2010 this has been replaced by the more sensitive ImmunoCAP Specific IgE test.

Children often develop food allergies to egg, milk, wheat, nuts, peanuts and soy, which are food allergies with positive IgE tests. When they age, their immune system develops tolerance to many of these foods and they often outgrow these allergies.

There are other popular lab tests where a blood drop is analyzed with IgG, IgM and IgE antibodies against a panel of foods. A number of suppliers offer these tests.  However, the specificity, sensitivity and reliability can pose problems with regard to the interpretation of the results: allergists often point out that a test may be a false positive when a person likes certain foods and IgG antibodies against this food show up despite the patient having no symptoms. Another specialist may interpret this to indicate that the body shows early sensitization to a certain food, but clinically it is not yet obvious. In other words the sensitivity of the test is so high that it undermines the validity of the test. Recently a panel of international scientists reviewed the validity of these IgG based food intolerance tests and they found the tests not reliable.

The immune responses to food allergies are complicated as there are immediate type immune reactions and delayed type immune reactions. The immediate immune responses are investigated with the above mentioned ImmunoCAP Specific IgE test. The delayed immune responses can be measured using the ELISA test.

Other considerations about allergies

You see from this discussion that a patient with allergies needs a properly trained allergist who will do a comprehensive analysis involving a thorough history, examination, blood tests and immune tests.  The test results have to be interpreted with the experience and the clinical judgment of the specialist.

Since the 1970’s when Clearfield wheat was introduced around the world on a large scale, which has a much higher gliadin (gluten) content than the old wheat varieties. As a result of exposure to this new type of wheat gluten intolerance and leaky gut syndrome have increased substantially in the world population. Genetically modified foods like soy, corn, sugar beets, canola and more have challenged the immune system of sensitive humans even more to an extent, which is not fully understood yet. We do know that some people can develop autoimmune diseases and this may be the reason that a host of diseases that belong into this disease category (MS, rheumatoid arthritis, Hashimoto’s thyroiditis, ankylosing spondylitis etc.) are much more common now than in the past.

After food elimination for 2 to 12 months depending on the severity of the food allergy, your body may have eliminated the allergy to the food you have avoided, in other words your body built up tolerance. Before you expose yourself to any food that you used to be allergic to and that you want to re-test, it is best to have an EpiPen ready in case your allergy has not resolved. Caution is necessary with regard to foods that cause more severe allergies, e.g. shellfish or peanuts, which may last life long. It is safer to avoid these foods that cause more severe allergies altogether.

Allergic reactions of the immune system belong into the category of chronic inflammatory diseases. These are known to be the root of chronic diseases like asthma, arthritis, heart disease, high blood pressure and cancer. When you are vigilant about allergies and get proper assessment and treatment by an allergist, you will prevent serious health problems including the above mentioned chronic diseases.

More on asthma, which is a chronic inflammatory lung condition, often associated with multiple environmental allergies:

http://nethealthbook.com/lung-disease/asthma-introduction/

Last edited Nov. 6, 2014

May
01
2006

Peanut Traces Still Present After Brushing Teeth

Education of the person with allergies is of great importance. Effective treatment does not only involve taking an antihistamine against allergies, which can be bought over-the counter. To get optimal control of allergy symptoms, evaluation with the help of an allergist is necessary, and skin tests will give more information. A regimen of allergy shots is an effective way to control allergies. It is also up to the allergic person to avoid substances that can be the cause of the problem. Allergy season triggers a lot of questions in patients who have had allergic reactions in the past. The most feared ones are anaphylactic reactions or anaphylactic shock from exposure to peanuts or ragweed. People with a history of allergies all have the risk of more severe reactions that need rapid intervention as anaphylactic shock can be deadly. People can be sensitized to various foods (peanuts, nuts, fish, shell fish, soy, wheat). Food additives often associated with allergic reactions can be sulfites (present in dried fruit and wine), food coloring (tartrazine) and flavor enhancers like monosodium glutamate. Beside those allergies, reactions to animal fur and dander, feathers, pollen of trees, grasses and weeds (ragweed being one of the worst) can be a challenge to allergy sufferers. People can get sensitized in any age group. Even adults who showed no allergic reactions in the past can come down with allergies later in life.

Patients with food-related allergies should be aware that an injection with adrenaline (epinephrine) could make a difference between life and death in severe allergic reactions. Carrying an EpiPen (an injectable dose of epinephrine) is one important way of having an “emergency break”. But carrying the device at all times is not enough. The user has to be fully knowledgeable as to how to use it and when to use it. Getting a prescription from the physician and proper explanation from physician as well as the pharmacist is the next important step.
Food allergies have received more attention over the past years. Food labels will show, whether a product may contain traces of nuts or peanuts, and many schools have banned the use peanuts among their students (see the result of an inadvertent exposure to peanuts in a child who is allergic to it in the image above). It may sound like a radical approach, but given the fact that peanuts have shown disastrous reactions in allergic individuals, it is not a surprise. A new Ontario law, which was passed in 2005, is geared to make schools safer for children with allergies. After 13-year-old Sabrina Shannon from Pembroke, Ontario died at school in 2003 following food-allergy related anaphylaxis, the law requires every school board to establish and maintain an anaphylaxis policy. School staff must be trained in dealing with life-threatening allergies and emergency procedures must be in place.
Studies by researchers at the Mount Sinai Medical Center in New York showed that levels of Ara h 1, the major peanut allergen has staying power. Volunteers who ate a peanut butter sandwich had the allergen in their saliva for several hours after the meal. Clearance took up to 4.5 hours. The researchers went on to assess several interventions: vigorous tooth brushing for two minutes, tooth brushing and rinsing the mouth twice with water, rinsing the mouth without tooth brushing, and chewing gum for 30 minutes. All those intervention reduced the amount of peanut allergen, but none uniformly removed it!

Peanut Traces Still Present After Brushing Teeth

Peanut Traces Still Present After Brushing Teeth

For persons with food allergies it is a warning signal: even a kiss from a person who recently ate the food (peanuts in this case) can cause dangerous allergic reactions. The presence of allergens in the saliva may or may not be applicable to other foods besides peanuts. More studies are needed, said Dr. Jennifer Maloney and her colleagues.

More information about treatment of asthma caused by peanut allergy: http://nethealthbook.com/lung-disease/asthma-introduction/asthma-treatment/

Reference: The Medical Post, April 4,2006, page 19-21

Last edited Oct. 31, 2014