Nov
22
2012

New Breast Cancer Treatment

By | Cancer, Health, Women’s Diseases

For decades the dogma in medicine has been that any kind of cancer, including breast cancer would be treated with surgery, radiotherapy and/or chemotherapy. However, the 5-year survival rates were disappointing as this table shows. In the 1980’s the idea of adjuvant treatments for cancer came up and one of the popular methods was hyperthermia treatment. Cancer cells of a variety of cancers were found to be very heat sensitive, but the limiting factor in treating with hyperthermia systemically was the fact that   bone marrow cells were found to be very heat sensitive, which limited this application. With respect to breast cancer a review of data pooled from 5 trials showed that there was an 18% survival advantage due to the added step of hyperthermia in addition to radiotherapy. With radiotherapy alone a group of advanced breast cancer patients had a 5-year survival of 41%, but a comparable group treated with a combination of radiotherapy and hyperthermia had a survival of 59%.

Let’s back track for a moment and ask what breast cancer is. In the past we thought it developed out of one mutated cell, a breast cancer cell that would multiply into a clone of cells, which would first grow locally and then spread as metastases throughout the body at a later time. Unfortunately further research has shown that breast cancer can simultaneously occur in several spots in one breast or even in both breasts. The spreading of the cell clones to distant areas can occur very early on, but cells can lay dormant for years and start growing again at a time when the immune system is weak. With these facts in mind it can readily be seen that surgery cutting out a “local breast lump” will not be successful in the long term as a treatment of breast cancer, even when radiotherapy treatment is added to sanitize the local lymph glands of local cancer metastases.  Adding chemotherapy to eradicate distant metastases may  sound like a good idea, but chemotherapy is very toxic to bone marrow cells and to the immune cells that are supposed to kill the last breast cancer cells. As a result, chemotherapy has its own problems. Medical researchers had to start thinking outside of the box to discover a breakthrough in breast cancer treatment.

Fast forward to 2012. We still need a breast cancer treatment method that is non-toxic, that kills the breast cancer cells and that ensures that there will be no recurrences in the future.

New Breast Cancer Treatment

New Breast Cancer Treatment

This new treatment method is called “laser-assisted immunotherapy“, and it is being studied in a pilot study right now. 62.5% of end stage breast cancer patients had a response rate, something that has never been achieved before. The systemic side-effects of hyperthermia are overcome by heating only locally and directing the laser beam to the diseased tissue. The quality of the Laser beam is close to the infrared frequency of light . This is amplified by injecting the FDA approved compound indocyanine green, which absorbs more heat from the laser beam right in the cancer cells where it is needed for local hyperthermia treatment. The immune cells and the bone marrow cells are not harmed. The killed cancer cells release the cancer antigens that the immune system could not recognized before, as the immune cells were suppressed by suppressor T lymphocytes. With this added immune booster which is called “glycated chitosan” the cancer patients’ immune cells(called “killer T lymphocytes”)  are now being stimulated and are in a position to eradicate the last trace of cancer cells anywhere in the body. This is similar to a vaccination procedure that takes place within the body of the cancer patient. The T lymphocytes remember the surface antigen of the cancer cells that were killed. As a result the same type of tumor will never reoccur in that person’s life. It also takes care of the dilemma of the past that sometimes more than one cell type clone was found among the biopsy material of a cancer patient.

At this point the trial has not reached the 5 year mark of survival. Only 15 patients of the total of 45 patients have so far been enrolled. But 80% of the 15 patients have survived 2.5 years, which is unheard of with stage IV (late stage) breast cancer. In an experimental breast cancer model in rats where laser assisted immunotherapy was first shown to be effective, there was 100% survival of the treated group. However, it was noted that it was essential that all three components of the new treatment modality were followed. The protocol for the human pilot study therefore is as follows:

1. After placement of an anesthetic in the tumor area the indocyanine green is injected into the tumor (placement of the photosensitizer).

2. The laser beam near infrared frequency of light is applied in the tumor area (or over the palpable metastases). This application takes about 10 to 12 minutes and two courses are given over two weeks. An option of a third course within one year may be considered, but did not have to be done so far.

3. The adjuvant immune booster (glycated chitosan) is injected into and underneath the tumor right after the laser treatment is finished.

This triple therapy is the secret to the success of the new breast cancer treatment as each step is augmenting the other steps resulting in a complete destruction of the breast cancer and an active immunization against any of the residual cancer cells.

At this point the offshore Caribbean breast cancer treatment pilot study has been chosen to bypass frustrating FDA slow-downs in the US. But I suspect that proper protocols in a much bigger randomized US based study will follow the obvious successes in these late stage breast cancer cases. New cancer therapies are urgently needed. They are typically introduced by treating “incurable” (late stage) patients first. We are about 2 1/2 years away from the completion of this pilot study so that 5-year cures rates can be compared to older studies with the conventional cancer treatment approach. I am convinced that this new approach will not only help breast cancer patients,  but will also help prostate cancer patients and pancreas cancer patients (these three come to mind as they all are glandular cancers). Surgery for the removal of lymph gland metastases in prostate cancer patients and breast cancer patients using laser assisted surgery with indocyanine green stained lymphatic tissue has already been pioneered. It also opens up possibilities of modifying the method to suit other types of cancers.

More information about breast cancer: http://nethealthbook.com/cancer-overview/breast-cancer/

Last updated Nov. 6, 2014

Dec
01
2008

Climb Stairs And Stay Healthy

By | Fitness, Health, Heart Disease, High Blood Pressure, Men's Health, Prevention, Women’s Diseases

Everybody knows that walking from the TV to the fridge does not qualify as exercise, and those few steps to the mailbox don’t do the trick either, when it comes to staying fit. But by the same token it is also a fallacy to believe that only the work-out in the gym will reap benefits and improve aerobic capacity. According to Dr. Philippe Meyer and colleagues at Geneva University Hospital in Switzerland, the mundane task of taking the stairs can show statistically significant changes in aerobic capacity, decrease in body weight, decrease in fat mass, waist circumference, decrease in diastolic blood pressure and increase in heart healthy HDL cholesterol. Dr. Meyer asked 77 healthy hospital workers including 20 physicians to exclusively use the stairs at the 12-storey hospital. During this 12 week quest for more fitness promotional signs encouraged stair climbing. All of those 77 participants were a sedentary group of individuals. Nevertheless they had to walk…the cafeteria was on the twelfth floor! At the baseline the participants walked up and down an average of 4.5 storeys per day, and at the end of the twelve weeks they were walking about 20.6 storeys per day.

Climb Stairs and Stay Healthy

Climb stairs and stay healthy

The tangible results showed that aerobic capacity and fat mass remained significantly improved, even though the participants walked less storeys after 12 weeks. It seems that initial change of habits-walking instead of taking the elevator- had made the difference in the transformation from couch potato to more active individual.

Stair climbing is an excellent exercise for healthy individuals in the general population. This high intensity exercise cannot be recommended to heart patients that are not entirely stable or to a patient who has angina. In these cases caution and a supervised exercise program is needed.

More information about fitness: http://nethealthbook.com/health-nutrition-and-fitness/fitness/

The Medical Post, November 18, 2008, page 17

Last updated Nov. 6, 2014

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Nov
01
2008

Early Childhood Weight Gain Leads To Weight Problems in Teens

By | Health, Nutrition, Obesity, Prevention

A Finnish Study enrolled 541 children in a prevention trial at the age of 7 months. The same children were seen again at the age of 13 years. Every year the height and weight were measured. By the time the children were 13 years old, 16% were classified as overweight, based on body mass index determinations. For girls, there was an abnormally high weight gain (2.8 to 7.5 kg annually) from the 3rd to 4th year until the 12th year of age while normal weight kids gained only 2.1 to 4.8 kg annually. Boys showed no difference in weight gain pattern until the age of 5 years or older. Now the boys who developed an overweight pattern showed an increase from 3.5 to 7.9 kg annually while normal weight boys gained only from 2.6 to 5.5 kg annually. With respect to the body mass index the upper limit of a normal was exceeded for girls at the age of 5 years and for boys at the age of 8 years. Another important finding of the study was that the parents of the overweight adolescents were also overweight while the parents of normal weight adolescents were also within the range of a normal body mass index.

Early Childhood Weight Gain Leads To Weight Problems in Teens

Overweight child turns into overweight teen

Two major risks of developing overweight and later obesity were found: overweight parents and abnormally high weight gain in early childhood (ages 2 to 4). The investigators concluded that treatment for developing overweight problems in childhood needs to be addressed at this age, not later when it is much more difficult to treat.

More information about health for children: http://nethealthbook.com/news/health-children/

Lack of B vitamins in children predicts obesity: http://nethealthbook.com/news/lack-b-vitamins-children-predicts-obesity/

Pediatrics. 2008;122:e876-e883

Last updated November 6. 2014

Oct
01
2008

Concerns Over Bisphenol A Bottles

By | Cancer, Health, Nutrition

Early in 2008 polycarbonate bottles containing bisphenol A (BPA) have been deemed “toxic” under the Canadian Environmental Protection Act. The compound was first identified by researchers that autoclaved (heat sterilized) their polycarbonate flasks. They were studying the growth of breast cancer cells and found that the chemical which was identified from the flasks promoted growth of breast cancer cells. No human research was involved, and the data come from tests in animal research. Nevertheless BPA is an “endocrine disruptor”, that mimics the action of estrogen, reports Dr.Rebecca Sherlock, clinical assistant professor of pediatrics at the University of British Columbia. The question that remained was the leaching of the substance into food. As an experiment, bottles with the content of BPA were subjected to conditions that simulate household use. They were run through regular household dishwashers, but they also were subjected to the use of industrial dishwashers that have higher temperatures. Also the bottles were subjected to scrubbing with steel wool. Dr. Sherlock reported that the final result is that there is leaching of the substance into foods. None of the studies showed that the quantity of BPA is higher than the acceptable daily intake limit set in the U.S.A. and in Europe.

Concerns Over Bisphenol A Bottles

Concerns Over Bisphenol A Bottles

There are animal results that there may be some health effects, especially in the brain, the prostate and other endocrine tissues. Due to these results the federal Health Minister has proposed a ban on manufacture, import, and sale of baby bottles. Newborn babies and infants may be more sensitive to the effects of the chemical. A lot of controversy has surrounded the polycarbonate bottles containing bisphenol A.
In August the FDA has declared them “safe’, but by September a report from the National Institutes of Environmental Health Sciences cited once again “some concern”. There are potential effects on the behavior, brain and prostate gland in fetuses, infants and children at the current exposure level.

More information about toxins in the environment: https://www.askdrray.com/protecting-yourself-from-environmental-toxins/

85th Annual Conference of The Canadian Pediatric Society (CPS) in Victoria/BC as reported by The Medical Post, Sept. 16, 2008, p. 14

Last edited November 6, 2014

Sep
01
2008

Survey Shows People Underestimate Lifestyle Factors As Cancer Causes

By | Cancer, Health, Nutrition, Obesity, Prevention, Weight loss

Roy Morgan Research Company and Gallup International have released an opinion poll study at the recent International Union Against Cancer’s World Cancer Congress in Geneva (August 27 to 31, 2008) that reveals significant differences among low-income countries and high-income countries. Cancer of the liver and other cancers can be caused by alcohol and throat and lung cancer as well as others are caused by carcinogens from cigarette smoking. These are medical facts that have been well established. But the opinion poll showed that there is ignorance and confusion in the public both in poor and wealthy nations. For instance in high-income countries 42% felt that there was no cancer risk from drinking alcohol and 8% were unsure, in low-income countries 15% were of the opinion that alcohol was not a cancer risk and 29% were unable to say. Other differences were that 62% of people in wealthier nations believed that cancer was one of the three top health issues in the country, while only 36% of people in poorer nations believed this. On the other hand with so much information about pollution in the press 76% to 78% of people living in middle and high income countries are of the opinion that this is an important cause of cancer while only 30% believe this in the poorer countries. The reality is that smoking and drinking of alcohol are more important in terms of cancer causation than pollution is.

Survey Shows People Underestimate Lifestyle Factors As Cancer Causes

Survey Shows People Underestimate Lifestyle Factors As Cancer Causes

David Hill, president-elect of the International Union Against Cancer, said that these opinion polls reveal data about attitudes and believes previously unknown. This kind of data can be used to formulate programs for cancer prevention so that the public is accurately informed about cancer facts and they learn in rich and poor countries alike that factors like smoking, drinking alcohol and a high body mass index are more significant cancer causes than pollution. Pollution is more difficult to control by the individual, but these life style factors can be modified, and people need to be empowered to make the right choices. People have the power to stop smoking, to cut down their alcohol consumption and to increase their exercise, which helps them to shed pounds.

More information about causes of cancer: http://nethealthbook.com/cancer-overview/overview/epidemiology-cancer-origin-reason-cancer/

International Union Against Cancer’s World Cancer Congress in Geneva (August 27 to 31, 2008)

Last edited November 3, 2014

Sep
01
2008

Ayurvedic Medicines Sold On Internet Can Contain Toxic Metals

By | Health, Prevention, Vitamins and supplements

In the wake of recalls on prescription drugs that showed hazardous side effects, many consumers seek alternatives. Often Ayurvedic medicine is seen as a less hazardous alternative, and medications are ordered on the internet or purchased in stores. There may be the notion that products that are manufactured in the US may be subject to stricter controls than imported items. All these assumptions leave the consumer confused as what to believe or trust. Investigators have tried to shed some more light on Ayurvedic medications. Six hundred and seventy three oral products were identified and random samplings of 230 products were purchased. Under the lead author Robert B. Saper of Boston University School of Medicine a technique called fluorescence spectroscopy was applied to examine the products for the presence of toxic metals. Of 193 products that were tested, 20.7% showed noticeable concentrations of toxic metals. Of those products that showed contamination 21.7% were US made and 19.5% were manufactured in India.The highest concentrations- namely 40.6%-were found in rasa shastra products, as compared to 17.1 % for non-rasa shastra products. The most prevailing contaminants were lead and mercury. Of these contaminated medicines 95% were sold by US websites, and shockingly 75% of the sites claimed “Good Manufacturing Products”.

Ayurvedic Medicines Sold On Internet Can Contain Toxic Metals

Ayurvedic Medicines Sold On Internet Can Contain Toxic Metals

All of the toxic metal levels exceeded standards for acceptable daily intake. Ayurvedic medicines are widely used in India and in other parts of the world. There are previous reports describing lead poisoning caused by these types of medicines. In rasa shastra products herbs are combined with metals such as lead, mercury, iron or zinc. Often mineral gems are also part of the compound. In view of the heavy metal levels the researchers suggest third party testing of the product and government-mandated daily dose limits.

More information on heavy metal poisoning:

1. From pollution: https://www.askdrray.com/protecting-yourself-from-environmental-toxins/

2. From cosmetics: https://www.askdrray.com/lead-still-poisoning-us/

Reference: JAMA. 2008;300:915-923

Last edited November 5, 2014

Aug
01
2008

Lead Poisoning Down, But Watch For Mercury

By | Health, Nutrition

The devastating results of lead poisoning in children have put consumers on alert. Lead in paint and in the glaze of ceramic products has gone unrecognized until the 1970’s. Since then stricter regulations have reduced or eliminated lead from paint products in North America. The additional move to unleaded gasoline has contributed to successful lead reduction. Consumers, however, should not let down their guard and be aware of the fact that there are still possibilities of lead exposure. Sources can be manifold. While most of lead exposure domes from old lead paint that was applied decades ago, especially in older homes, some exposure can come from imported toys, which just recently made headlines in the news. Some exposure can also come from medications and “nutritional products” imported from overseas. Imported cookware and other products have also been a significant source of lead contamination. The general awareness has paid off, as there is a significant reduction of lead levels since the ‘70’s. Public health warnings have been issued about mercury levels in fish, and this has led to concerns in consumer groups whether it is safe at all to consume fish. Blowing the warning whistle alone does not do a service to consumers. It is much more important to inform consumers to recognize, which of the fish species are averaging less than one tenth of Canada’s commercial mercury limit if 0.5 parts per million.

Lead Poisoning Down, But Watch For Mercury

Lead Poisoning Down, But Watch For Mercury

Dr. Copes, director of environmental health at the B.C. Centre for Disease Control explained at a recent meeting that salmon, rainbow trout and tilapia fall into this group of fish that can be enjoyed more frequently, whereas other species, such as halibut, tuna and sablefish have levels of mercury that are five to ten times higher. They are still under the commercial limit, but it means that the consumer could enjoy 10 meals of salmon as opposed to one meal of halibut, tuna or sable fish. The recommendation is not total avoidance, but less frequent consumption.

Reference: The Medical Post, July 22, 2008, page 17

Comment on Nov. 17, 2012: The oceans are continuing to deteriorate with regard to mercury content. It is no longer safe to eat halibut, tuna or sable fish. Salmon, rainbow trout and tilapia should be limited to perhaps once per week. Avoid salmon that has migrated past Japan because of radioactive contamination of the coast region there (due to the earth quake in March 2011, the devastating tsunami and subsequent radiation crisis from the nuclear plant).

More information about toxins in the environment: https://www.askdrray.com/protecting-yourself-from-environmental-toxins/

Last edited November 4, 2014

Jul
01
2008

Have A Cup Of Coffee And Decrease Your Death Risk

By | Health, Heart Disease, Nutrition

Coffee can be good for you, and this is one of the items, which even tastes good! There are some exceptions as discussed in previous articles: more than 2 cups per day can increase the risk for miscarriages in pregnant women. People who are anxious or nervous can find that coffee will aggravate anxiety. Patients with rheumatoid arthritis should also not indulge in the flavorful brew.

Aside from these exceptions researchers have found that coffee consumption can be beneficial. A recent study using the data from 41,736 male and 86,214 female subjects has evaluated data over a follow- up time of 18 years in the male group and 24 years in the female group. The risk of all-cause mortality decreased significantly with increasing coffee consumption in the male as well as in the female group.

Men had a relative risk reduction of 20% as compared to their counterparts with the lowest level of coffee consumption. Women with intermediate to high consumption had a relative risk reduction of 10% to 30 % as compared to the group that drank less than 1 cup of coffee per day.

Have A Cup Of Coffee And Decrease Your Death Risk

Have A Cup Of Coffee And Decrease Your Death Risk

The limit of the study in this case was the self-reported nature of coffee consumption, but the researchers feel that the modest benefit of reduction of all-cause and CVD death warrants further investigation.

Reference: June 17, 2008 Annals of Internal Medicine

Last edited December 4, 2012

Jun
01
2008

Boost Babies’ Health with Mom’s Diet

By | Allergies, Asthma, Health, Nutrition, obstetrics, Prevention, Vitamins and supplements

Prenatal supplements and good advice on proper nutrition during pregnancy have long been included in proper prenatal care. Importance has been placed on folic acid to prevent neural tube defects in the fetal development. Calcium is recommended, often in the form of dairy products, but it does not end there: just swallowing the supplement and adding some more milk may be helpful but not quite enough. Certain dietary habits have been found more beneficial, such as the eating habits in the Mediterranean countries. A research team from the University of Crete in Heraclion, Greece included women who were involved in antenatal care at all general practices in Menorca, Spain. The study took place in the time frame of 12 month starting in 1997. After six and a half years 460 children were also included in the analysis.

Dietary habits were studied and assessed by food questionnaires and the children were assessed for the development of allergies and asthma.

Boost Babies’ Health with Mom’s Diet

Boost Babies’ Health with Mom’s Diet

The children of mothers who consumed the most vegetables, fish and legumes were almost 80% less likely to have persistent wheeze and more than 40 % less likely to have allergies. The results are consistent with the fact that a high level of adherence to the Mediterranean diet during pregnancy is protective not only to the mother but also to the child.

More information about prenatal visits (where nutritional habits are checked as well): http://nethealthbook.com/womens-health-gynecology-and-obstetrics/pregnancy-labor-delivery-2/prenatal-visits/

Reference: The Medical Post, April 22, 2008, page 25

Last edited December 18, 2014

Apr
01
2008

Short Daily Exercise Helps Chronic Pain Patients

By | Arthritis, Fitness, Health, Pain

Chronic pain can be an affliction that turns normal living and functioning upside down. Quality of life will be negatively affected, and often depression and anxiety are resulting mental problems. Effective pain relief is crucial, but often there are undesirable side effects to pain medication, and the patient will explore other avenues that bring a measure of relief. Amy Burleson, Psy.D. of the Cleveland Clinic’s chronic pain rehabilitation program found that chronic pain patients were physically deconditioned due to chronic pain and a chronic lack of physical activity. Depression and other mood disorder also were very common. A 10 minute exercise program was added to the treatment of a group of 28 patients who suffered of various chronic pains: back pain, fibromyalgia, neuropathy and migraines. Patients started a simple routine of walking on a treadmill, starting with a low speed of 1 mile per hour and increasing the speed every few minutes, till they walked at a speed of 3 miles per hour, a speed which was manageable for all patients. After 3 weeks patients found that their physical endurance had increased. They also experienced less depression and anxiety. Even more remarkable was the fact that the patients’ pain perception had diminished.

Short Daily Exercise Helps Chronic Pain Patients

Short Daily Exercise Helps Chronic Pain Patients

Likert scale scores which were used in the assessment of pain perception showed a drop from 7.32 in the beginning of the program to 2.75 at 3 weeks. It is obvious that even mild exercise has benefits for patients with chronic pain: the overall well being receives a noticeable boost through an approach that has no pharmacological impact, no side effects and has no high cost of health care.

More information on the right dose of exercise: http://nethealthbook.com/health-nutrition-and-fitness/fitness/right-dose-exercise/

Reference: Pain Medicine, Volume 9, Issue 1, Page 88-141 (January/February 2008)

Last edited November 3, 2014