May
18
2013

Treatment For Alzheimer’s Failed, But Prevention Succeeds

Recently another news story about a failed drug against Alzheimer’s disease (AD) went through the news media as shown in this link.

Donepezil, galantamine, rivastigmine and memantine are the most common drugs used to attempt to treat Alzheimer’s as this review explains. None of these drugs are a real breakthrough with regard to truly curing AD, as the drugs only achieve a few months of delay in the eventual deterioration of the AD patient’s symptoms. On the other hand there is an overwhelming accumulation of data in the last few years showing that many different factors can prevent AD and dementia. Below I am reviewing all these preventative factors and steps.

Genetic and epigenetic factors in Alzheimer’s disease

Early onset Alzheimer’s disease occurs between 30 and 60 years of age. It is due to a genetic predisposition (mutations on genes of chromosomes 1, 14 and 21). Only about 5% of all AD cases are caused this way. The remaining 95% of Alzheimer’s cases are due to late-onset Alzheimer’s disease. Here the causation is due to a combination of genetic, environmental and lifestyle factors. One genetic risk factor in this group is important, namely the apolipoprotein E gene (APOE), which is located on chromosome 19. There are several forms of APOE as this review explains. It also states that there is so much variation between the various APOE forms and even the worst form of this does not necessarily mean that the person who has this will come down with late-onset Alzheimer’s disease. So APOE is presently only used in research projects. Your doctor will only order genetic tests in people who have a strong family history of early onset AD.

There is another genetic marker, the CYP46 gene that was found to be present in some late-onset AD patients. If it is combined in a patient with the APOE gene, there is a much higher chance of developing AD as this review shows.

Epigenetic factors are probably more important than genetic factors for most cases of late-onset AD, as this review explains. Another review came to the same conclusion.

What are epigenetic factors? Exercising, replacing missing hormones, using a calorie restricted, only 15-20% fat containing diet; and taking supplements as listed below that will keep harmful genes in the “off” position and protective genes in the “on” position. Taking these preventative steps is probably more powerful than using any of the presently available medications mentioned above.

Treatment For Alzheimer’s Failed, But Prevention Succeeds

Treatment For Alzheimer’s Failed, But Prevention Succeeds

Exercise, diet, control blood pressure

As already mentioned, these are some of the powerful epigenetic factors that will prevent AD down the road. Controlling blood pressure has long been known to improve cognitive function. It is now evident that there seems to be a problem with microcirculation in brain tissue before it comes to neurodegenerative changes of AD and the underlying deficiency in nitric oxide production in the lining of the diseased arteries. Other research has shown that a lack of nitric oxide (NO) production is also the underlying problem with hypertension.

Green vegetables such as kale, spinach, also cabbage varieties and red beets are a source of nitric oxide and have also been shown to prevent AD at the same time.

Add to this exercise and you have a winning combination for the prevention of AD. You guessed right: exercise increases NO production from he lining of your arteries. When people age their lining of the arteries does not produce as much NO as in younger years. However, there is a supplement available, Neo40 Daily, that can be taken twice a day to compensate for this.

Here is another report about a 30% to 40% reduction in the incidence of AD when people do regular, simple exercises.

More good news about fruit and vegetables: tomatoes, watermelons, pink guava, pink grapefruit, papaya, apricot and other fruit all contain lycopenes, which have been shown to prevent AD.

Recently a new testing tool in combination with a PET scan of the brain has been developed, which may help the treating physicians to assess improvement or deterioration of an AD patient objectively using this method. However, this is still considered to be only a research tool at this time.

Supplements to prevent Alzheimer’s disease

The following brain-specific nutrients play a part in the prevention and treatment of AD (according to Ref.1):

1. B-vitamins: they are important to support the energy metabolism of brain cells.

2. Vitamin C: this has antioxidant properties and prevents brain cells and supportive glia cells from oxidizing.

3. Vitamin E in the form of mixed tocopherols: together with vitamin C has been shown to prevent Alzheimer’s disease

4. Phosphatidylserine (PS), with an intake of up to 300mg/day: counteracts and prevents memory loss.

5. Coenzyme Q10 (ubiquinone), 100mg/day (it would be safe to take 400 mg per day, which is also cardio protective): stabilizes the mitochondria of brain cells and heart muscle cells. It is a powerful neuroprotective agent and supports ATP production (energy metabolism of brain cells).

6. Ginkgo (Ginkgo biloba), at a dose up to 240mg/day: increases micro vascular circulation, neutralizes free radicals from oxidation and improves short-term memory.

7. Omega-3 fatty acid and DHA, 1500mg/day: has anti-inflammatory properties.

Other nutrients that hold promise are:

8. Huperzine A, 100 to 200mg/day: natural anticholinesterase inhibitor, derived from the Chinese club moss, surpasses donezepil according to studies by doctors in China

9. Vinpocetine, 2.5 to 10mg/day: comes from the periwinkle plant, increases cerebral blood flow and stimulates brain cell metabolism

10. Turmeric extract (curcumin) is very beneficial in reducing tau protein deposits in AD.

All these statements and dosages are cited from Ref.1.

Hormones to prevent Alzheimer’s disease

According to Ref. 1 there are certain hormones that can prevent AD: DHEA, pregnenolone, estrogen (bioidentical estrogen only).

  1. DHEA is persistently low in AD patients and replacement with DHEA at 50 mg daily has shown improvements in muscle strength and energy of AD patients.
  2. Pregnenolone has been shown to be a powerful memory enhancer in animals and humans alike.
  3. Estrogen, if taken as bioidentical estrogen cream (Bi-Est) can improve brain function. Estrogen is a strong epigenetic switch that keeps a woman mentally younger for longer, but has to be balanced with bioidentical progesterone cream to prevent breast cancer and uterine cancer. A study showed that estrogen replacement early in menopause will cut down on the heart attack rates, but it is also known, particularly when given as bioidentical hormone cream to prevent AD.
  4. In addition progesterone has been described to be of value in the aging woman to preserve brain metabolism.
  5. Testosterone is known to protect against Alzheimer’s disease in the aging male.
  6. Melatonin at a starting dose of 1 mg to 3 mg at bedtime often helps to restore the disturbed sleep pattern, but also augments the effects of the other hormones (Ref.1).

Removal of toxins, particularly mercury

Mercury is extremely toxic in minute amounts and affects brain cells preferentially. Intravenous vitamin C/glutathione treatments as described in this blog will remove mercury from your system including the brain.

It may take 20 to 30 such treatments in weekly intervals followed by a maintenance program every two to three weeks to remove mercury from the body.

Other heavy metals can accumulate in the brain as well and must be removed. This is described here in more detail.

Conclusion

There have been major breakthroughs in prevention of Alzheimer’s disease and dementia over the past few years, many unnoticed by the media. The search is still on for an effective drug that would treat AD when it is present. However, this may be 10 or 15 years away and we cannot afford to wait that long. Instead I suggest that people should embrace the concept of preventing AD by using as many of the factors described above. Both at the 2011 and the 2012 Anti-Aging Conferences in Las Vegas several speakers pointed out that a combination of several preventative factors will be much more effective than one factor alone and they estimated that about 80% of AD could be prevented this way.

References

Ref.1. Rakel: Integrative Medicine, 3rd ed., Copyright © 2012 Saunders, An Imprint of Elsevier. Chapter 9 – Alzheimer Disease. Integrative Medicine: “Kirtan Kriya, Telomeres, and Prevention of Alzheimer Disease”, by Dharma Singh Khalsa, MD

Last edited Dec. 18, 2014

May
05
2013

Get Rid Of Toxins Safely

This article is about “get rid of toxins safely”. You often hear that people use chelation at home with natural foods. Is that true?

The standard chelation detoxification

I like to mention in the beginning that the proven way to reduce heavy metals in the blood (typically mercury and lead) is by intravenous chelating agents such as EDTA. However, the lowering of calcium levels as a severe side effect limits the application of it. There are also blood-thinning side effects to consider. EDTA is a chemically synthesized compound, not a natural substance. Conversely, vitamin C and Glutathione are both antioxidant substances that the body knows; they are non-toxic and can be used more easily intravenously to remove heavy metals like lead and mercury with fewer side effects than EDTA.

Natural ways to use chelation in order to detoxify

Although I think that EDTA has a place in the hands of those who are knowledgeable about the side effects, the vitamin C/Glutathione combination is probably a more physiological detoxification method as glutathione is synthesized by the liver to detoxify our bodies. Intravenous chelation is expensive, requires access to a vein and may not be a suitable way for many people to detoxify. There are natural ways to detox for those who cannot afford chelation or cannot chelate for other health reasons.  The major detoxification organs are: the liver, the kidneys, the gut, the lungs and the skin.

What about oral methods to detoxify?

Several methods of cleansing are fasting, the major cleanse or the raw food cleanse. I would not advise to do strict fasting without fluid intake as it takes fluid intake to be able to dissolve any released toxins into urine, feces, invisible fluid from exhaled air and nasal discharge. Next there is the “master cleanse” with lemon juice, maple syrup and cayenne pepper as indicated in the link above. Some people like trendy procedures that they find in a magazine or in a self-help book. I do not like it, as it reminds me too much of a cookbook approach.

A Vitamix is a good tool to create turn your fruit/vegetables into a chelating tool

I feel differently about a raw food cleanse as I will explain. First, I like to point out that raw food is not easily digested as your gut absorbs only about 30 to 40% of the nutrients. The cell walls of the vegetables you use are the barrier towards absorption. This is much different, if you put the raw fruit and vegetables into a blender with a high-power motor. (There are several brands like the BlendTec or the Vitamix.) The powerful blending process breaks up the cell walls and releases the content of the plant cells including their enzymes and nutrients, so that 80% of the nutrients are absorbed in your gut.

Get Rid Of Toxins Safely

Get Rid Of Toxins Safely

If you use organic ingredients (they do not contain toxins, artificial fertilizer residues etc.) you cannot go wrong! Use spinach, kale, banana, mango, greens, lemon juice, and for fat add some nuts like walnuts, Macadamia nuts, almonds (with the proviso that you are not allergic to them). With the help of a powerful blender all this will turn into a liquid drink that actually tastes OK. For protein supplementation I would also add some protein supplement like vegan protein from the health food store, whey protein or egg white protein (good to rotate these protein supplements). This mix is a complete nutritional program as it contains complex carbohydrates from fruit and vegetables, fat from nuts, protein from the protein supplement and fiber (from the whole vegetables and fruit).

Natural detoxification from organic fruit and vegetables

You will not get hunger pangs as with a fast or the master cleanse. Use the signs of your body as guidance. If you feel energized after 5 days, stop then and return to your normal food intake. This is a zone type diet, a Mediterranean diet or South Beach diet as explained below. Some people have the willpower to do 7 to 10 days of the liquid diet described. Good for them, at least they do not starve themselves as the calories and total nutrient content are there while they detoxify. What are the agents that lead to the detoxification process? The enzymes from the fruit and vegetables, the lack of toxins as you only consume organic ingredients, the extra vitamin C from the food and the glutathione from your liver are all working together for detoxification.

Are there supplements that can help you to detoxify?

Chlorella powder, which you can buy in health food stores, is one of the few supplements that can detoxify your body from heavy metals. As Dr. Mercola describes that in Japan chlorella powder is one of the most popular supplements to detoxify. It is difficult to get a complete, non-biased picture about chlorella. I did an extensive research in MD Consult about the scientific evidence for detoxification by chlorella in humans. Unfortunately, the search results came back only for experiments with mice and rats, but there were no human detox results.

Chlorella detoxification

Perhaps the Wikipedia description about the history of algae and chlorella as a possible food supplement sheds some light on the difficulties getting real hard data on chlorella detoxification. Researchers poisoned rats deliberately with cadmium (a heavy toxic metal). There was no evidence of detoxification with chlorella when the researchers stopped cadmium poisoning. However, the article goes on to say that chlorella did prevent absorption of cadmium from the intestines to a certain extent (in rats).

Liver detoxification and colonic detoxification

Dr. Max Gerson invented coffee enemas many years ago when he treated end stage cancer patients with natural methods. He found that when he detoxified them with raw juices, many cancer patients died from the toxic breakdown products of dying tumor cells. So he was in dire need of a procedure that would remove the toxic tumor substances efficiently.  This is when Dr. Gerson used coffee enemas. As the link above describes, coffee given through the colon as an enema (we would perhaps call it “coffee colonics” today) stimulates the liver and the bile flow thus detoxifying the blood effectively of toxic materials. In addition, the secretory capability of the large surface of the colon wall also helps the detoxification process. Juicing in combination with coffee enemas improved Dr. Gerson’s end stage cancer cure rates dramatically.

Dr. Kelley introduced supplementation with Mega pancreatic enzymes

Subsequently, Dr. Kelley developed his nutritional-metabolic therapy for end stage cancer patients where he added large amounts of pancreatic enzymes in addition to coffee enemas. Dr. Denis Burkitt is credited for recognizing the importance of fiber in the diet. He noticed that there was a striking difference between the colon cancer rates in England versus the rates in Africa. He analyzed food habits in both locations and found that in England there was not enough fiber consumption.

Diet high in vegetables, fruits and whole grains reduces colon cancer rates

A large study done by the Harvard Medical School showed that it was not so much the fiber that helped to prevent colon cancer. Further large scale studies were done and it was shown that a diet high in vegetables, fruits, and whole grains was what was responsible for a reduction in colon cancer rates. This type of diet will also help detoxify your system from carcinogenic substances in general and from other toxins as the soluble fiber inside the gut will attach to it and go down the toilet instead of being reabsorbed in the colon into your system causing cancer.

Skin detoxification

The skin is the largest body organ with a lot of skin surface where skin pores can help detoxify under the right circumstances. You can achieve this with infrared saunas, with exercise that leads to production of sweat and by soaking in Epsom salt baths. Traditionally this has been done for centuries in the European spas, originally described by Sebastian Kneipp. The medical establishment in Europe (France, England, Germany, Austria), unlike American physicians, embraced the concept of natural therapies under the term “balneology”, at least for a number of decades. But  overuse by patients (abusing the system), badmouthing the relatively weak effect of detoxifying by Big Pharma and lack of funds from the health insurance companies put a damper on his movement. Part of this approach was the use of skin detoxification with healing baths (using Epsom salt and other salts) and physical exercise to the point of sweating.

Wechselbäder according to Sebastian Kneipp

In addition, “Wechselbäder” according to Sebastian Kneipp (alternating hot and cold baths) are also useful to stimulate the circulation and the immune system. The major component of Epsom salt is magnesium sulfate, which can be absorbed through the skin to a certain degree. So, some of the healing effect of Epsom salt baths may have come from an indirect balancing of low blood magnesium and the normalization of many metabolic processes that require magnesium as cofactors. Here is another, more vernacular description of Epsom salt use. Some of the assumptions such as improvement of diabetes, improvement of digestive absorption or relief from migraine headaches may be a combination of exaggeration and placebo effect rather than reality.

Kidney detoxification

The kidneys along with the liver are the major, natural detoxification organs of the body. However, they need enough fluids to dissolve water-soluble toxins and eliminate them from the body through the urine. Consume clean water intermittently during the day (reverse osmosis water in glass bottles or BPA free bottled water). Because alcohol is a cell poison damaging the vital organs like the brain, heart, liver and kidneys it is best to minimize any alcohol intake to the absolute minimum (best to avoid alcohol altogether). The main filtration devices in the kidneys are the glomeruli, little packages of convoluted capillaries, which filter the blood several times per day.

Too much salt and sugar interfere with normal glomerulus function

High salt intake, too much sugar and too much starch interfere with normal function of the glomeruli. Insulin resistance in cases of metabolic syndrome and diabetes (often in people with obesity) can damage the kidneys.  In this case the filtration devices of the kidneys suffer damage and cause toxin accumulation. To prevent damage of the kidney capillaries you need a healthy, basic diet like the Zone diet, South Beach diet or the Mediterranean diet as mentioned in this link.

This will keep fat deposits out of your arteries and maintain the capillaries of the glomeruli of your kidneys. This means that the filtration process continues to work until a ripe old age. Your doctor can order tests (creatinine clearance) to assess whether the filtration capacity of your kidneys is normal.

Many toxins are fat-soluble

Many toxins are fat-soluble and store in the fatty tissues. When you lose weight, you need to drink more fluids to get rid of the water-soluble toxins. This occurs through the kidneys. You can also use coffee enemas to rid yourself of fat-soluble toxins (through bile and bowel movements).

There are a lot of websites that want to sell you herbs that should cleanse your system. They have a marginal effect. But I like to stress that you want to adopt one of the diets mentioned above first. This starts you with a healthy baseline. Such herbs as Buchu (Agathosma Betulina), Burdock, Echinacea and Yellow Dock Root (Rumex Crispus) are supposed to help the kidneys to detoxify. I am not certain whether there is medical proof for this.

Conclusion

Detoxification starts with adopting healthy food and lifestyle habits first. A low carb, low fat type diet (zone diet, a Mediterranean diet or South Beach diet) are essential. They are the footing from which the other detoxification methods work. Some of the toxins will leave you when you work out and sweat. More will leave you when you enjoy an Epsom salt bath. This gives you some extra magnesium, which in turn detoxifies your system. The detoxification takes place  through several biochemical reactions where magnesium is a cofactor. Colonics or enemas will help remove toxins through your colon and they are more effective when coffee enemas are used (stimulation of your liver through the splanchnic nerves).

Infrared saunas

Infrared saunas can help to mobilize toxins and detoxify them through your skin. Take ample amounts of fluids as this will help remove some toxins through the kidneys and the urinary system. If the physician detects major heavy metal poisoning, the traditional intravenous chelation treatments are more recommendable. A naturopathic physician or A4M physician (anti-aging physician) could advise you what is best in your case. Overall the thought is that by removing toxins the mitochondria in our cells will work more efficiently. They are particularly concentrated in the brain, heart, liver, and kidneys. When they work more effectively they give you more energy and prevent major diseases. These diseases are cancer, cardiovascular disease (heart attacks and strokes), diabetes, arthritis and loss of cognitive function. The latter prevents Alzheimer’s disease and dementia.

More information about:

1. Chelation therapy: https://www.askdrray.com/tact-study-proves-effectiveness-of-chelation/

2. Vitamins, minerals and detoxification: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/vitamins-minerals-supplements/

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Apr
21
2013

On World Health Day 2013 the Focus is on Hypertension

Introduction

This article is about this: on World Health Day 2013 the focus is on hypertension. In the US high blood pressure causes 348,000 American deaths per year, in the world its death toll amounted to 9.4 million every year. This is unfortunate as high blood pressure is an illness, which can both be effectively treated and prevented. Uncontrolled high blood pressure (hypertension) causes heart attacks and strokes, can cause kidney failure, heart failure and blindness. You control blood pressure with lifestyle changes and/or medication,  and these risks go away.

The age standardized death rate  (Ref. 1) for both sexes in the US for heart disease is 80.5 per 100,000 and for strokes 25.4. In Canada these rates are 66.2 and 22.9. For  Germany the rates are 75.0 and 31.2, in Italy 51.7 and 34.9 and for Japan 31.2 and 36.7. The death rates from cardiovascular disease per 100,000 people in the same countries is as follows: in the US 172.2, in Canada 130.7, in Germany 200.2, in Italy 153.5 and in Japan 107.1.

There are obviously significant differences in these countries, which I will discuss further below.

Topic of high blood pressure

World Health Day was celebrated on 7 April 2013 to commemorate the founding of the WHO in 1948. In 2013 the topic of high blood pressure made the World Health Organization edit a PDF publication of 155 pages. It is entitled “Global Atlas on cardiovascular disease prevention and control” (Ref.1, be patient, loads slowly). In it prevention and treatment for high blood pressure are discussed in detail. This text points out that there has been a remarkable decline in death rates from heart attacks and strokes (collectively called “cardiovascular disease”) between 1981 and 2000 in the United Kingdom.

Decline in death rates from heart attacks and strokes

A thorough analysis of this showed that 58% of this decline was due to risk factor reduction in the whole population. This included reduction of smoking and heavy alcohol consumption, reduced salt intake, combatting physical inactivity and reduction of saturated fat intake. The other 42% of the decline in cardiovascular disease is due to treatment by a physician. So, it is clear from this that the majority of mortality prevention comes from the patient, less than 50% comes from the treating physician. However, it is important that physicians will educate their patients to cut out risk factors themselves in order to prevent hypertension.

World Health Day 2013, Focus on Hypertension

World Health Day 2013, Focus on Hypertension

Risk factors for high blood pressure

On World Health Day 2013 the focus is on hypertension. In the past it was thought that most cases of high blood pressure would be due to “essential hypertension”, a term saying “we don’t know what causes high blood pressure”. Many physicians still use this term. Physicians thought that only a small amount of cases were due to “secondary” hypertension with an apparent cause (e.g. kidney disease, hormonal imbalance, pregnancy). But in the meantime research by Harvard University and other research institutions has shown that there are a number of specific causes that contribute to high blood pressure, either alone or in combination.

Common causes of high blood pressure

Here are the commonly known causes: too much salt in our diet; we tend to not eat enough vegetables and salads; we like to sit in cars, in front of the TV or in front of the computer (physical inactivity). Many people still smoke, although tobacco is known to cause high blood pressure and lung cancer. Too much alcohol is known to cause hypertension as well. So the following steps will prevent high blood pressure:

  1. consuming less salt
  2. eating a balanced diet (preferably the DASH diet)
  3. engaging in regular physical activity
  4. avoiding tobacco use
  5. avoiding harmful use of alcohol (more than 2 oz. or 60 Grams per day)

Diabetes worsens the risk for heart attacks and strokes

Physicians know that diabetes worsens the risk for heart attacks and strokes and increases the risk of high blood pressure as well. So, some hidden risk factors for high blood pressure related to diabetes are as follows: a high fasting blood sugar; obesity; food with too much fat, too much sugar and too many starches (not enough complex carbohydrates).

What can we do to reduce death rates from high blood pressure?

As Canada is one of the countries where the death rate from strokes and heart attacks is lower than in the US or Germany, I like to point out some of the reasons for this. I practiced medicine in Canada for many years. The “Canadian Hypertension Education Program” have been guidelines for practicing physicians to follow providing effective screening and treatment of high blood pressure. Cardiologists at various continuing education conferences have promoted this.

High blood pressure recalls at my medical office

At my office I had a hypertension recall program where my staff called every patient with high blood pressure into the office every 3 months. We would review the home-measured blood pressure readings from the patient (recorded in a little booklet). I also took the blood pressure of the patient and so did my staff on the patient’s arrival. We reviewed the blood pressure medication and reviewed the possible side effects. I explained to the patient what to do, if the blood pressure was higher than normal (possible adjustments of the medication at home). I also encouraged my patients with regard to the life style issues (the 5 points mentioned above). Over the years the number of patients who developed heart attacks or strokes declined, as one would expect.

Literature review in the medical journal Canadian Family Physician

A recent review in the Canadian Family Physician mentions that there is room for improvement regarding the Canadian statistics. As mentioned above Italy and Japan are doing better with regard to mortality from heart attacks and strokes compared to Canada. We have a health care system in Canada that is available to every Canadian resident and funded by provincial taxes. In this system patients do not have to pay for office visits (although they pay for it indirectly through taxes). For the patient with high blood pressure, it means that there is a system in place, which helps prevent cardiovascular disease and treats high blood pressure effectively. In my opinion the home recording of self-measured blood pressure readings at least once per day with a home blood measure monitor is vital to encourage the patient to be engaged with regard to his/her blood pressure problem.

Newer findings about high blood pressure

For years physicians did not know where high blood pressure came from. In the last few years research has shown that nitric oxide plays an important role in preventing high blood pressure. The lining of your arteries produce nitric oxide (by the so-called “endothelial cells”). This is the natural artery relaxer.

Foods that produce nitric oxide in the body are spinach, kale, red beet, cabbage varieties and other vegetable greens. These foods, which are also contained in the DASH diet, and regular exercise will stimulate the lining of your arteries to produce nitric oxide, which prevents high blood pressure, heart attacks and strokes.

Treating high blood pressure with medication

If these measures and recommendations to prevent high blood pressure do not help, it is time to treat it. It is important that the patient who needs high blood pressure treatment with medication, takes the medicine regularly. This has the name”compliance”. By keeping the blood pressure reading below 120/80 you prevent your risk of getting a heart attack, a stroke, heart failure or blindness from broken retinal vessels. If the patient develops any side effect from the medication, it is important to see the physician about this right away. It may be that the medication has to be adjusted or altered.

Nitric oxide

Nitric oxide can be taken as a supplement (Neo40), which allows the endothelial lining to be regenerated as indicated in this interview with the inventor, Dr. Nathan Bryan from the University of Texas Health Center in Houston.

The older we are, the more likely it is that our blood pressure will be high. As this link shows, 2 out of 3 people above the age of 60 in the US have systolic hypertension (the upper value of the blood pressure is elevated). As we age, it appears that the lining of the arteries do no longer produce the required amount of NO (nitric oxide). NO is necessary to prevent high blood pressure and prevent hardening of the arteries.

Adopt the Mediterranean diet 

So, it would be wise to adopt the Mediterranean diet. This includes lots of vegetables, spinach, kale, bok choy, Swiss chard and others to boost your NO production. You still measure your blood pressure regularly. If you do not have a home blood pressure monitor, go to a pharmacy that allows you to check your blood pressure for free. If it is above 120 over 80 seek the advice of a health professional. You can find more information in Ref. 1.

In essence, what World Health Day 2013 asks us to do is to pay attention to your blood pressure and make sure it is normal.

More on high blood pressure: http://nethealthbook.com/cardiovascular-disease/high-blood-pressure-hypertension/

References

Ref. 1)  http://www.nethealthbook.com/articles/cardiovasculardisease_hypertension.php

Last edited Nov. 6, 2014

Apr
14
2013

Allergies Not Only In Spring

This article is about “allergies not only in spring”. Springtime is the time of spring allergies: those affected develop a runny nose, itchy eyes and in more severe cases they may experience a flare-up of asthma. Allergies can be triggered by the increase of pollen counts in the air that occurs every spring. In those who are sensitive, this leads to antibody formation in the blood. But often people have not only sensitivities to the pollens of spring bloomers; they may also be allergic to spores from molds, to dust mites and may have underlying allergies to foods.

Memory cells of the immune system

The immune system has memory cells that memorize that a person has had an allergic encounter to one of these items in the past, and allergic reactions can become more significant with a future encounter. Allergies often get worse when a person has food sensitivities and there are cross reactions between pollens of trees or grasses that share surface protein regions with similar protein regions in foods.

Cross allergies

It is known that cross allergies are possible between birch pollen and apple, carrots or hazelnut. In its extreme form allergies due to antibodies, called IgE antibodies, can cause anaphylaxis. A person presensitized by inhaling birch pollen, after eating an apple, hazelnuts or a carrot can develop itching of the throat, swelling of the lips and very quickly deteriorate getting into an anaphylactic shock.

Other cross allergies exist between ragweed pollen, which is a powerful inhalant allergen and melons or bananas. Again there are specific IgE antibodies that are responsible for this immune reaction. In this case the ragweed allergy primes the immune system to produce IgE antibodies, which are experience potentiation by certain foods that share similar protein components as the ragweed pollen.

In the following I will deal with inhalant allergies separately from food allergies.

Inhalant allergies

Inhalant allergies are easier to diagnose and to treat than food allergies. Your doctor will likely refer you to an allergist when you have allergies that do not respond to treatment with intermittent over the counter antihistamines. Your symptoms may come on in the spring with itchy eyes and a runny nose. From year to year you find that you become more and more dependent on antihistamines and nose drops to unplug your nose. The allergist likely will do sensitivity tests, which consist of skin prick or scratch tests on the back or the forearms.

Allergy shots to stabilize allergies

In more serious allergies, where the patient has coughing and wheezing attacks following allergic reactions, the allergist may suggest to start intermittent allergy injections alongside the standard inhalation therapy for asthma. The allergist prescribes an allergy serum where the lab mixes ingredients based on all of the positive tests that led to a strongly positive skin reactions through allergy testing.

Allergy injections

Typically, the family doctor or his nurse will start the allergy injections initially in weekly intervals.  After reaching the  maintenance dose, there may be a modification to injections every 10 to 14 days.

The allergy injections stimulate the immune system to produce harmless competing antibodies, which counteract the disease producing allergic antibodies. In the process of desensitization shots the immune system will normalize, which means that the inflammatory response of the immune system settles down to normal.

This is not the end of the story with inhalant allergies. The allergist needs to retest the patient on a yearly basis. The immune system changes all the time as new allergies can develop and old ones may go away.

Retesting allergies and sublingual immunotherapy

Retesting is necessary to keep track of what is going on and to change the composition of the allergy serum. Those patients who are working together with the allergist can do very well, and often they gradually outgrow their allergies. Others may not be so lucky. They may have reactions to the allergy injections. In these cases avoidance of what causes the allergy may be the only solution to treat the allergies.

There is an alternative to allergy injections, which physicians in Europe use, namely a sublingual immunotherapy. Recently there has been a review of the literature for FDA approval that is needed for oral desensitization for ragweed, dust mites, grass pollen and cat dander. It will take some time before the FDA approval process will become a reality for sublingual desensitization in the US.

Allergies to pets

A special form of inhalant allergies are allergies to pets (mainly dogs and cats, but also allergies to petting zoo animals). The dander that the human comes in contact with is a protein from the animal hair. It causes hives when it touches the skin. This occurs as the dander penetrates through the skin and meets the local mast cells that release histamine. This in turn is responsible for the hive formation. Sneezing and even asthma can develop from inhaled protein particles that reach the lungs. Allergy injections for the treatment of animal dander allergies often do not help or make the allergies worse. The allergist usually recommends avoidance of animal contact as the solution, a recommendation, which the affected animal lover often does not appreciate.

Allergies Not Only In Spring

Allergies Not Only In Spring

Food allergies

Often we eat  some foods more frequently, because they are our favorites. This means that our gut lymphocytes that get in contact with these foods can start to react to one or more of the foods we ingest. At this time we may experience abdominal cramps, diarrhea, vomiting and a host of other possible symptoms.

The physician will tell the patient that testing for food allergies is a problem. Most of the usual skin tests employed for inhalant allergies do not reliably work in determining food allergies. The doctor will ask the patient or the mother of the child with food allergies to keep a food diary and keep track of the allergic symptoms in the diary as well. An elimination diet will have to be devised based on the information gathered in the diary as it becomes clear from that record which foods cause which symptoms. The foods causing allergic symptoms are subsequently eliminated. This is a cumbersome process, but it is the most reliable method of testing and treating food allergies.

RAST test

In the past there was a blood tests, called RAST test, which tested for common food allergies that can cause severe allergic reactions like egg, milk, peanut, tree nuts, wheat, crustacean shellfish and soy. Since about 2010 this has been replaced by the more sensitive ImmunoCAP Specific IgE test.

Children often develop food allergies to egg, milk, wheat, nuts, peanuts and soy, which are food allergies with positive IgE tests. When they age, their immune system develops tolerance to many of these foods and they often outgrow these allergies.

Antibody tests for food allergies

Only a blood drop is necessary to test a panel of foods with IgG, IgM and IgE antibodies. A number of suppliers offer these tests.  However, the specificity, sensitivity and reliability can pose problems with regard to the interpretation of the results. Allergists often point out that a test may be a false positive when a person likes certain foods. IgG antibodies against this food show up despite the patient having no symptoms. Another specialist may interpret this to indicate that the body shows early sensitization to a certain food.  However, clinically it is not yet obvious. In other words, the sensitivity of the test is so high that it undermines the validity of the test. Recently a panel of international scientists reviewed the validity of these IgG based food intolerance tests and they found the tests not reliable.

Testing for food allergies

The immune responses to food allergies are complex as there are immediate type immune reactions and delayed type immune reactions. The physician investigates the immediate immune responses with the above mentioned ImmunoCAP Specific IgE test. The delayed immune responses can be measured using the ELISA test.

Other considerations about allergies

You see from this discussion that a patient with allergies needs a properly trained allergist who will do a comprehensive analysis involving a thorough history, examination, blood tests and immune tests.  The specialist interprets the test results, which requires his/her experience and clinical judgment.

Clearfield wheat

Since the 1970’s when Clearfield wheat was introduced around the world on a large scale, which has a much higher gliadin (gluten) content than the old wheat varieties. As a result of exposure to this new type of wheat gluten intolerance and leaky gut syndrome have increased. Scientists registered a substantial increase in wheat gluten intolerance in the world population. Genetically modified foods like soy, corn, sugar beets, canola and more are a challenge for the immune system. This is particularly so  in sensitive humans. Physicians do not fully understand why this is so. We do know that some people can develop autoimmune diseases. This may be the reason that a host of diseases are much more common now than in the past. Common autoimmune diseases are MS, rheumatoid arthritis, Hashimoto’s thyroiditis, ankylosing spondylitis and others.

Epi-Pen, chronic inflammatory diseases

After food elimination for 2 to 12 months depending on the severity of the food allergy, your body may have eliminated the allergy to the food you have avoided, in other words your body built up tolerance. Before you expose yourself to any food that you used to be allergic to and that you want to re-test, it is best to have an EpiPen ready in case your allergy has not resolved. Caution is necessary with regard to foods that cause more severe allergies, e.g. shellfish or peanuts. These type of allergies may last life long. It is safer to avoid these foods that cause more severe allergies altogether.

Chronic inflammatory diseases

Allergic reactions of the immune system belong into the category of chronic inflammatory diseases. These are known to be the root of chronic diseases like asthma, arthritis, heart disease, high blood pressure and cancer. Be vigilant about allergies and get proper assessment and treatment by an allergist. You will prevent serious health problems including the above mentioned chronic diseases.

More on asthma, which is a chronic inflammatory lung condition, often associated with multiple environmental allergies:

Apr
07
2013

Caution, Processed Food Ahead

Introduction

The title of this review is: caution, processed food ahead. During the last month there have been three large studies that drew media attention regarding healthy food intake. The first study dealt with processed meats (sausages, ham, bacon). Over 12.7 years those consuming 160 Gm per day (=5.64 oz.) were 44% more likely to die prematurely than those who ate only 20 Gm (=0.7 oz.) of processed meat per day. The study included 10 European countries including about 500,000 people over almost 13 years; nearly 10,000 people died from cancer and 5,500 from heart problems.

Harvard study 

Then there was the Harvard study that analyzed 114 national dietary surveys around the globe and came to the conclusion that every year there are 180,000 obesity related deaths from overuse of sugary drinks. The US stands third highest on the ranking list regarding deaths from drinking sugary soda pops. The deaths are due to heart attacks, strokes and diabetes, which associate with obesity.

15% of all death around the world from salt overuse

As if this was not enough the third bad news story came shortly after story about salt overuse: At a cardiology conference in New Orleans Dr. Dariush Mozaffarian, the main author regarding the sugar study mentioned above, revealed a long-term study regarding salt intake between 1990 and 2010 .  He determined that 15% of all deaths that occur around the world every year (which translated into 2.3 million people) are the result of salt overuse. The recommended salt limit is 1500 mg per day. But many people in the study consumed 4000 to 6000 mg of salt per day or more. This led to hypertension, heart attacks and strokes with the yearly mortality rates indicated.

Caution, Processed Food Ahead

Caution, Processed Food Ahead

What do these studies have in common and why is processed food so devastating?

All these studies pointed out that processed foods are dangerous to your health. Sausages, ham and bacon contain a lot of fat and salt; they are full of extra calories and they elevate your fatty substances in your blood (triglycerides, cholesterol). The extra salt raises your blood pressure. Processed meat is also poor in omega-3-fatty acids. No wonder that they can cause heart problems and cancer.

Sugar and processed food

Next, we have the sugary soda drinks, but also the hidden sugar in starchy processed foods like cookies, bagels, bread and cakes. Dough and pasta digests within 30 minutes into sugar, which your gut absorbs and your liver processes as extra calories to be stored as fat. Where? As visceral fat and subcutaneous fat, and the end result is obesity. At the same time the sugar from soft drinks and the sugar from starches stimulate the pancreas to produce extra insulin, which leads to hyperinsulinemia and insulin resistance. This is known as metabolic syndrome and was found to be an independent risk factor for heart attacks apart from high LDL cholesterol and high triglycerides. We know for quite some time that obesity, diabetes, insulin resistance and metabolic syndrome are all associated with a higher rate of deaths from heart attacks and strokes.

Salt overuse

Finally, there is the salt overuse story. In 2009 the same Harvard group that gave us the world data on salt mortality now, stated that 102,000 Americans die every year from salt overconsumption. The same study cited that 82,000 Americans die needlessly every year due to their love affair with deep fried foods (due to high trans fatty acids) , and 84,000 die from a lack of omega-3-fatty acids in their diet, which when present in the diet protects from heart attacks and strokes.

Food processing

What does food processing do? It reduces or eliminates dietary omega-3-fatty acids, adds cheap oils containing omega-6-fatty acids (the fatty acids that lead to inflammation), adds salt, sugar and starch. It is the perfect recipe to die from strokes and heart attacks. The same research group from Harvard University did a study in India, published in 2010, where they established that salt over consumption caused insulin resistance and this was the cause of higher mortality from heart attacks and strokes.

Other studies pointing to the dangers of processed food

Deficits in cognitive function (dementia or Alzheimer’s disease) are associated to dietary habits, particularly sugar and starch overconsumption. Research has established that hyperinsulinemia or insulin resistance is responsible for the degenerative changes in the brain of Alzheimer patients. This study also pointed out that these diets are typically very low or deficient in omega-3-fatty acids, which is necessary for normal nerve cell metabolism in the brain. The lack of it leads to brain cell disease like Alzheimer’s and a lack of omega-3 fatty acids in nerves leads to damaged nerves which in turn cause excruciating pain.This condition is also known as neuropathy.

Gout was around in the Middle Ages

In the Middle Ages it was first observed that overindulging in red meat and sausages caused gout attacks. A nickname for gout was “a disease of the rich”. Higher uric acid levels, which are found in gout have been linked to higher mortality rates from heart attacks and stokes. A low purine diet can lower the risk for gout and also the risk for heart attacks and strokes. It is interesting that this type of a diet is also devoid of processed food at the same time.

What can we do to reduce dangers to our health?

We have identified the suspects; it is sugar, starchy foods, salt and processed meats. Instead of just buying precooked meals, boxed foods and other processed foods from the center of the grocery store or from a fast food place, look for original ingredients more at the periphery of the grocery store.  Read food labels and look for sugar, fat and salt content. Start buying organic food and buy the ingredients you need to prepare a meal by yourself. When you start preparing your own meals with organic ingredients, you may as well avoid the toxins that I described in a recent blog.

Buy organic foods

By buying organic foods, you largely avoid these toxins. Don’t exceed your daily limit of 1500 mg of salt, as your kidneys are not able to process this and would cause you to get high blood pressure. Personally, I cut out all sugar and starch from my diet since 2001. This includes potatoes, pasta, bread, bagels, French fries, toast etc. However, you will get enough complex carbohydrates (from vegetables and greens). The body absorbs them much slower and does not cause the insulin surge by the pancreas. In contrast, highly processed carbs lead to an insulin surge.

Omega-3 fatty acids important for health

You want to eat foods rich in omega-3-fatty acids, but seafood (even salmon) has a contamination with mercury. You can circumvent this by taking 3 or 4 capsules of high potency, molecularly distilled omega-3 per day. This is free of toxins and protects your brain and nerves from the dangers mentioned above. Your organic vegetables/greens have enough natural minerals that you will seldomly want to add salt to your food. Do not add extra salt when you cook or when you eat your prepared meals. Use spices instead. Also avoid eating out too often. Restaurants are notorious for overusing salt.

More information

More information on nutrition: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/

Other links:

1. Processed meat: http://www.huffingtonpost.com/2013/03/07/processed-meat-cancer-heart-disease-death-risk_n_2829092.html

2. Sugary drinks: http://www.cnn.com/2013/03/19/health/sugary-drinks-deaths/index.html?hpt=he_c2

3. Alzheimer’s and pre-diabetes with insulin resistance: http://www.usatoday.com/story/news/nation/2012/10/17/carb-diet-alzheimers/1637481/

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Apr
01
2013

My Experience With Cancer Research

This article is about my experience with cancer research. April is cancer awareness and fundraising month. I thought it would be interesting to analyze what’s going on behind the scenes of cancer research. I was a cancer researcher for over 3 years at the Ontario Cancer Institute (OCI) from 1972 to 1975 and I will share some insider experiences here.

1. Publish or perish

Our supervisors said: “publish or perish”. In other words all the experiments we did needed to fit into the larger picture the group was working on. And the results should be different, interesting and most of all publishable. There had to be significant differences between experimental groups and controls. This was a requirement by publishers of medical journals would accept them for publication. There were often two or three manuscript revisions where the content was “massaged”.  I had to pay attention to proper wording and comparing or opposing the results with other publications. This way the publisher deemed the manuscript “publishable”.

2. Fund raising awareness

One of the major fund sources for cancer research in Canada was the MRC (Medical Research Council of Canada), which has been replaced by the Canadian Institutes of Health Research (CIHR) in 2000. Without money there is no cancer research, so everybody was aware of the policies and expectations of the fund source.

3. Mouse model versus human tissue based research

My work was in the immunology section of the biophysics department, where researchers perform basic medical research at the OCI. In this department much research had already been performed separating cell populations in a mouse model to determine what cell types were needed to initiate an immune response. The B cells in mammals are antibody-producing cells of the immune system that protect from viruses. T cells are lymphocytes, which the body processed in the thymus. They turn into killer cells, which can attack parasites and also cancer cells. I was working in this area.

Cell separation experiments and doubts about mouse research

We did cell separation experiments. With this method I was able to separate cells according to cell size and collect them in vials. Subsequently I did remix experiments. The purpose was to find out which cell types were able to mount an immune response. My supervisor suggested the use of a mouse tumor cell line as targets. I started questioning whether a mouse model would be the appropriate model to study human cancer biology. But my superiors were not in agreement. The “holy grail” was that to work in a mouse model (mouse mammalian cells).  The assumption that this should also work in the human situation (human mammalian cells).

My Experience With Cancer Research

My Experience With Cancer Research

4. Non-medical researchers in cancer research

This is a thorny issue, but a reality. My immediate supervisor in cancer research had a PHD in physics. His physics degree was perfect for sorting out density issues for cell separation experiments. The co-chair of the immunology department had a PHD in biology. His qualification was good for conducting mouse experiments. Both of them felt somewhat insecure when I asked questions. I wanted to know how relevant mouse experiments were for the examination of human cancer conditions. As I needed to publish my experiments, I had to quiet down and concentrate on the mouse model the team was working on. For a while this could even be exciting as we were studying the cell interaction between macrophages and T cells to mount a cell-mediated immune response.

5. Regulation of the cancer research industry

After playing with cell cultures for 2 ½ years it was time for me to reach out to get a job in the cancer research field or else go back to medicine. In1975 there was no equal opportunity legislation in place that would have protected me as a landed immigrant from discrimination. The reality in 1975 was that only Canadian born physicians who attended a Medical School in Canada could become a director of a cancer research facility in Canada. The rules for me (I had left Germany right after my rotating internship) were that I had to go through further medical training and pass the Canadian licensing exam (LMCC), which I did eventually at McMaster University in Hamilton, Ontario.

Interview with Dr. McCulloch

One final attempt to shed light on my options was an interview with the “big boss” at the Ontario Cancer Institute at the time, a physician cancer researcher, Dr. Ernest A. McCulloch, for whom I had great respect. He was a sharp thinker and had vision, and he was a fellow physician. I asked him what he would do on the long-term, if he was in my place. He said that in the long-term with my medical background it would be a lot more satisfying for me to get back into medicine and practice medicine. However, he wanted me to go on for another 1 or 2 years and publish more papers together with my supervisors.

My decision to leave cancer research

I decided for myself right there that I would leave cancer research and I prepared quietly for my exit. Within a short time I got a position to work as an intern at a hospital at McMaster University and in the spring of 1978 I passed the LMCC (licensing) exam. As a fully licensed physician in Canada, I was no longer interested in “slave work” in cancer research. I also left the cold winters of Ontario behind and went to the west, to British Columbia.

6. Future vision of medical cancer research

Research has come a long way. Recently I came across a new breast cancer protocol, which is non-toxic, without chemotherapy and without radiation. It is so unconventional that the US research team, aware of the politics in the US, decided to do the initial trials in the Caribbean. I wrote a blog about this new breast cancer treatment protocol, which I believe will become the future standard for breast cancer therapy and perhaps even for other cancers.

Alternative breast cancer treatment

In Germany and Switzerland an alternative breast cancer treatment consists of with mistletoe extracts. This is a non-toxic plant chemotherapy, which slows down tumor growth. It has a dual action, namely a chemotherapeutic effect, but at the same time an immune system stimulating effect. Here is a study going back to 2001, which is still relevant. There was a 40% long-term survival benefit in the Iscador group when compared to a control group without treatment. Normally, oncologists jump at such an excellent chemotherapeutic agent as they even consider chemotherapeutic agents that with a 25% beneficial survival effect a good treatment option. However, as the medication is a simple mistletoe extract and cannot be patented, Big Pharma is not interested in marketing this. As a result cancer treatment protocols in Europe are significantly different from those in North America.

The future of cancer treatments

In the future I would expect that non-toxic treatment methods for any type of cancer will be more successful than any chemotherapeutic or radiation treatment approaches as both interfere with the immune function, which is what will kill the patient at the end. Cancer is a disease where the immune system fails. So, cancer patients need teaching how to stimulate their immune system. This is the only thing that controls cancer on the long-term.

You will hear more about epigenetic switches as often a cancer producing substance will turn off a gene (epigenetic switch) and this causes cancer.  Remove what throws that switch into the off position or introduce a healing agent that resets the switch and the cancer will get eliminated.

7. Prevention of cancer

Researchers noticed that herbs, spices, vitamins and minerals contain the most powerful cancer preventatives. Did you know that curcumin, derived from the Indian spice turmeric, prevents a number of cancers? Similarly, vitamin D3 at high enough doses (4000 to 5000 IU per day) has been shown to prevent cancers. Linus Pauling showed long time ago that vitamin C at high enough dose would be an antioxidant and would stimulate the immune system and thereby be a cancer preventative. It works together with a detoxifying antioxidant, glutathione in the liver to neutralize any free radicals, which are aggressive chemicals that cause cancer.

Learning from risk factors for cancer

There are many other vitamins and minerals that I have explained elsewhere, which are needed together with organic food to give you the building blocks for a stable cell metabolism. This in turn will strengthen the immune system to defend you from toxins of the environment. A simple step like a daily exercise routine can cut your cancer risk down to 50% compared to those who elect to not exercise. Did I mention the importance of quitting smoking and cutting out alcohol? The “quit smoking” part has been known for some time.

Alcohol is a cell poison and can cause cancer

At the Anti-Aging conference in Las Vegas in December 2011 I learnt about the importance of alcohol exposure that causes cancer. Even smaller doses of alcoholic beverages over a long period of time can cause cancer. First I thought it would be a big deal to quit alcohol entirely. But since I have quit the modest few drinks per month, I actually have not missed them at all! I strongly believe in cancer prevention, so quitting alcohol completely was only one small step in this overall objective. In view of the recent statement by the WHO that 70% of all deaths are caused by smoking and drinking of alcoholic beverages, it behooves us to change our lifestyles, if we are at all interested in a healthy long life.

Conclusion

Nothing has changed in cancer research circles since the time when I was part of it. Basic cancer research involving animal experiments is necessary. But in my opinion cancer research should be more human-centered using human cell lines in culture and using clinical trials. Ultimately cancer research needs to invent and develop new non-toxic cancer therapies to cure cancer patients.

More on cancer in general and on specific cancers: http://nethealthbook.com/cancer-overview/

Last edited Nov. 6, 2014

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Mar
24
2013

Living In A Toxic World

The following article is about living in a toxic world. In the past nobody worried about toxicities except parents when their children were gnawing on lead paint. Paint always contained lead and people thought that it was only children we had to worry about. We thought that adults were “immune” to this. We learnt a lot about lead toxicity from early studies in Germany and it was there that EDTA was developed in 1935 to treat children with lead toxicity. During the Second World War when ships were painted with lead containing paints many soldiers were poisoned with lead. EDTA treatment protocols that had been developed earlier for children were found to be also effective for these soldiers.

Lead poisoning from Chinese made toys and mercury poisoning from the air

Fast forward to 2013. We all have heard of lead poisoning from Chinese made toys, from Chinese fashion jewelry and we have heard of the melamine poisoning of baby food and candies. These are not the only poisonings. Mercury is in the air; it is also present in light bulbs and in cruise ship exhaust fumes from incineration of light bulbs and batteries. We have over 600 chemicals and carcinogens in cigarette smoke, which is perhaps the largest “legal” roulette game involving humans where several poisons are inhaled at once. Our water is chlorinated or fluoridated, which interferes with our thyroid gland function. Vegetables that are supposed to be healthy for us contain residues from insecticides and herbicides that have estrogen-like activities called xenoestrogens.

Xenoestrogens can cause breast cancer

They are known to cause breast cancer in women and prostate cancer in men. Milk in the US often contains antibiotics and genetically modified bovine growth hormone (rBGH), which again can cause various cancers in humans as this link shows. rBGH is banned in Europe and in Canada. The problems do not stop at chemicals in our water, environment, food and air, the newest threat is genetically modified food like wheat, corn and high fructose corn syrup, which is manufactured from GMO corn. Other GMO foods are golden rice, sugar beet, yellow crookneck squash, cotton for cottonseed oil, soybeans, canola, Hawaiian papaya, just to name a few. GM food is illegal in most European countries, but the US is trying very hard to push for “fair trade practices” in order to expand the market for GM foods.

Living In A Toxic World

Living In A Toxic World

GMO and endometriosis

How does all of this affect your body? One of the publications from France found that genetically modified food is likely responsible for the increase of endometriosis in women. This link explains that xenobiotics-associated genetically modified foods contain glyphosate (a herbicide) and Cry1Ab protein that affects the women’s hormone metabolism and causes the lining of the uterus to become invasive to cause endometriosis. There have been attempts to study toxicity of GM foods in animal experiments, but the pitfall was a wrong testing time of only 90 days , which was chosen for these experiments, and “no differences” were found between test and control animals (all the official statements about GMO food “safety” in the US are based on these “standard tests”).

The effects of GMO food

However, there are other studies that found significant differences after only 4 weeks of feeding rats and mice 10% GMO food mixed with regular feed as this link shows. The full impact of genetically modified foods is not evident until 3 generations or more in animal experiments, which is the equivalent of 90 years or more in humans. This is 80 years from now because significant amounts of GM food were in the food chain from the food industry for about 10 years. The definition of one human generation generally is 30 years. The animal studies show that with GMO food there is a higher mortality in rats and mice and that infertility is getting worse from generation to generation.

Toxic effects of heavy metals

With respect to chemicals patients detect toxic effects on the body a lot faster than with GMO foods. The toxins such as carcinogens and xenoestrogens are often fat-soluble, which means that obese people have more toxins stored than lean people. Mercury, cadmium and lead were found in a study to have caused specific protein folding problems within the cells. This explains bone marrow toxicity, liver and kidney toxicity and brain and heart toxicity. In other words, these are the organs where cells contain most of the mitochondria in the body and heavy metals are blocking their energy metabolism leading to aberrant body functions. As a result auto-immune diseases have increased dramatically, inflammatory conditions are common, and cancer rates are up.

How do we defend ourselves in a toxic world?

1. Food preparation living in a toxic world

First you need to switch from regular foods to organic foods. Also throw out all the foods in your fridge that are not organic and that contain MSG in it’s many disguises. MSG is an excitotoxin, which kills brain cells. These suggestions are also what Dr. Paula Baillie-Hamilton is recommending. Organic foods do not contain any of the problematic GM foods. They are also free of rBGH, xenoestrogens, residual herbicides or residual insecticides. Switch to either organic milk and milk products or goat milk and goat milk products. As some toxins will be released from the fatty tissue, if you are obese or overweight and you loose weight, it is advisable to use psyllium seed husks as a supplement to bind the toxins in the gut for elimination. Fiber from organic fruit and vegetables or oat bran are also beneficial.

Buy organic, avoid restaurants

On the long term it is less money to buy organic foods and prepare your own meals than going out to restaurants to eat. It is also much healthier and tasty. Avoid fast food chains as their processed foods contain artery clogging trans fats, GM foods and other questionable ingredients like “pink slime”. You do not need a cooking class to prepare a decent dinner. Read cookbooks for inspiration and modify the recipes to suit your own style. Remember to use only organic ingredients. You can’t create a healthy meal with non-organic ingredients mixed in (it’s like you start adding poisons). Break the old habits, do it right! Replace butter with olive oil. Replace sugar with organic stevia (a plant sweetener).

Avoid wheat flour

Avoid flour (especially wheat flour). Replace it, if you must with flour from oats, spelt or farro (at this point none of them have undergone genetic changes). Because wheat has been chemically modified in the 1960’s and 1970’s and gliadin is about 7-fold higher, brain receptors react differently than to the “old” wheat. As a result many individuals find that they want more- bread, pasta, wheat cereal, bagels…you name it! The huge surge in obesity is just the final result. Cutting out wheat and otherwise reducing the intake of grains may be a big step, but  is well worth the effort! Another problem with bakery products is that the food industry is using bromine for rising and chlorine for bleaching so this adds to the toxic burden of the thyroid gland. Cut out wheat, pasta and bread and you will gain health.

2. Detoxification living in a toxic world

If you had a lot of exposure to heavy metals in the past, you may want to see a naturopath for intravenous chelation treatments with vitamin C (10 Grams) and glutathione (1250 mg) every two weeks for some time until they are out of your system. If you have a lot of silver/mercury amalgam tooth fillings, let your dentist remove them. Ask your dentist to replace them with non-amalgam ceramic, gold inlets or crowns. Don’t use fluoride toothpaste despite your dentist’s recommendation: it is toxic as it poisons enzyme systems in your body and causes cancer of the intestines over a longer period of time. Use  a fluoride-free toothpaste from the health food store. After dental cleanings refuse the fluoride gel for the same reason. Brush your teeth frequently and floss your teeth regularly after meals. Your heart and cardiovascular system will thank you for this.

3. Eliminate other toxins from your personal care products

Check your cosmetics, shampoos, hair conditioners as well as your underarm deodorants, body wash, lip balm and sun tan lotion. Do they have parabens, triclosan (often in deodorants) or phthalates in them? They are weak carcinogens or immune disruptors. If they do, replace them with a healthier product from the health food store that does not contain these harmful ingredients. Use BPA free plastic containers for water during sport activities, they are quite affordable and can be ordered online. BPA free food containers are also available in super markets, department stores and some drug stores.

4. Clean up your home environment

Avoid toxic cleaning agents, solvents, paints, and other chemicals. If you have to deal with chemicals, be sure to ventilate your living spaces. Use latex paint instead of oil-based paint, if possible and air out well until dry. Always use vinyl gloves to protect your skin.  The body absorbs thinners or paints through the skin within a few minutes and are toxic to your system. If there is construction in your house or you move into a new home, air out frequently by opening the windows on and off until the “new” chemical odors disappear. New clothes contain chemical agents from the factory; wash them frequently until the chemicals disappear. Avoid fabric softeners as they are chemicals (or use a biological product, if you feel you must use one).

5. Pay attention to your water living in a toxic world

The water utility company treats drinking water with chemicals (fluorine, chlorine or bromine) to make it bacteria free. It is best to drink only reverse osmosis water, bottled water, distilled water or mineral water. Home owners are doing well to remove for the rest of the household fluoride, chlorine or bromine from the tap water. with A good carbon filter can do that for you. Talk to your water treatment company.

6. Hormone balance living in a toxic world

The aging process and the toxins in our environment affect our hormone glands and we produce less hormones as we get older than our ancestors did, but our ancestors overall did not live as long as we are today. A lot of this is due to exposure to immune disruptors like BPA’s from the older water bottles and long-term exposure to xenoestrogens (from residues of artificial fertilizers on non-organic vegetables).

You need balanced hormones

We need balanced hormones; it is important to have them checked by a knowledgeable doctor. Either an A4M anti-aging physician, a naturopath or a functional medicine physician can help you. Replace missing hormones only by bio-identical hormone creams, not by synthetic factory produced pseudo-hormones. Common problems as we age are hypothyroidism, sex hormone deficiencies both in women and men, but also human growth hormone deficiencies in some (measured by IGF-1 blood levels). Without proper hormone balance all the organic food in the world will not be the answer to good health.

7. Vitamin and mineral supplements living in a toxic world

Finally, vitamin and mineral supplements are important to support the mitochondria in your cells. Although no vitamin and mineral list is ever complete, I have summarized what I consider to be essential here. Start simple with only vitamin C, omega-3 fatty acids, vitamin D3 and a multiple vitamin and mineral supplement. You can always add more later.

The only other thought is to take a slow-release capsule of iodine twice per day. This would protect you from radioactive iodine in the environment or food.  Compounding pharmacies may be your best source. One capsule generally contains 5 mg of elemental iodine and 7.5 mg of iodide. As time goes on you may want to gradually investigate the other supplements.  See whether they would be suitable in your particular case.

How to age gracefully

We all would like to enjoy a long and happy, disease-free life. This goal is no longer achievable by sticking to the old eating habits. Needless to say, that smoking and drinking are out too, because they are toxic to your system. You may as well enjoy organic foods and gradually work yourself through the 7 points I mentioned above. This will ensure that the mitochondria of all your major organ systems will function at their best. As a result, you will feel energized and age gracefully!

More information on vitamins, minerals, supplements and detoxification:

http://nethealthbook.com/health-nutrition-and-fitness/nutrition/vitamins-minerals-supplements/

 

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Feb
19
2013

Forget The Glass Of Red Wine For Good Health

This article is about the statement “forget the glass of red wine for good health”. For over 10 years there was the rule to limit alcohol intake. It said  “1 glass of red wine for women and 2 glasses of red wine for men” daily.  This was the recommendation in order to prevent a heart attack or a stroke. Now we are confronted with new research from Boston showing that even small amounts of alcohol are bad for you as alcohol is a carcinogen (=cancer producing substance). Misinformation like this occurs when science concentrates only on one angle of health. Researchers focussed on cardiovascular disease prevention.  The other part of the equation, the carcinogenic effect of alcohol, was disregarded.

Australian study about the risk of cancer from alcohol consumption

In 1996 this Australian study followed 1236 men and 1569 women 60 years and over for more than 5 years and studied their mortality rates as a function of alcoholic drink intake. The authors found that there was a short-term protective effect with regard to cardiovascular/stroke mortality. Mortality was the end point for both cardiovascular disease and for cancer. Researchers took the study as evidence that alcoholic beverages protect to a certain degree from strokes and heart attacks. The authors were aware that alcohol was cancer causing as they stated, “Those taking any alcohol exhibited an increased proportion of deaths due to cancer at the expense of a reduced proportion of CHD and stroke deaths”.

Popular press is often misleading

But the popular press never mentioned this part in popular articles. Also, alcohol/cardio-protective recommendations did not mention the cancer danger. The authors also were aware that the observation time of 5 years was on the short side. We know from other studies that alcohol toxicity requires a longer observation time such as 15 to 20 years or longer to show significance in a multitude of cancers.

Alcohol consumption linked to cancer risk

As already mentioned above, the new survey of alcohol-caused cancer went through the popular press. Dr. Timothy S. Naimi from Boston University Medical Center was the main investigator of an international team of scientists. The study found that alcohol consumption is responsible every year for 18,200 to 21,300 cancer deaths in the US (that is 3.2% to 3.7% of all US cancer deaths). The authors of the study determined that every person who dies from alcohol related causes lost on average approximately 18 years of his/her life (scientists call this “years of potential life lost”).  51% of women developed breast cancer from alcohol exposure, 62% of men came down with upper airway and esophageal cancers. Less than 1.5 drinks per day caused between 26% and 35% of alcohol-related cancer deaths. No safe lower margin existed. The authors concluded, “Reducing alcohol consumption is an important and underemphasized cancer prevention strategy”.

Other research supporting the statement: “forget the glass of red wine for good health”

Interestingly, in 2006 other research looked at alcohol caused cancer cases in the world based on WHO data and concluded that with the increased worldwide consumption of alcohol, particularly in East Asia, preventative steps regulating consumption of alcoholic drinks would be wise.

A recent study in 2012 where cancer rates in the US were compared between Hispanics and Caucasians showed that Hispanics had higher rates of stomach cancer, liver cancer, uterine/cervix cancer and gallbladder cancer. The authors concluded that more screening is necessary in Hispanics  such as Pap tests. Also this ethnic group requires effective vaccines (like Gardasil) against the human papilloma virus. In addition, patients need to reduce obesity, curtail alcohol consumption and reduce tobacco use.

There is no safe level of alcohol consumption, not even the “1 drink for women and 2 drinks for men” (heart attack prevention), because cancer incidence increases with increasing alcohol consumption in a linear relationship.

Effect of alcohol on the body

What does alcohol do in the body that it is so dangerous to your cells? Many cancer researchers have researched this question in detail. Essentially, alcohol is by itself a toxin for your cells (the targets being sub particles in your cells called microsomes and mitochondria). Your liver metabolizes alcohol into acetaldehyde, your kidneys excrete it and your lungs exhale it (this is how a breathalyzer can detect how much you have been drinking). All of these chemical changes in your cells release free radicals, which in turn attack other cells. This sets up a chronic inflammatory process, which breaks down your immune system, leads to cell mutations and finally to cancer.

Forget The Glass Of Red Wine For Good Health

Forget The Glass Of Red Wine For Good Health

Protection from cancer and cancer prevention

What protects you from cancer?  It is the antioxidants that stabilize the above-mentioned processes: vitamin C, glutathione, vitamin D 3, curcumin, multiple vitamins, magnesium, flavonoid foods, cruciferous foods (like broccoli), exercise and soluble fiber.

So, if you were serious about cancer prevention, you may want to stop any alcohol intake. Instead take the above mentioned supplements. The heart attack and stroke protection will be achieved by flavonoid foods (perhaps specifically adding resveratrol 250 mg per day as well) and exercise.

If you were less conscientious about cancer prevention, at least reduce your alcohol consumption. Perhaps you want to drink the occasional glass of wine or beer. But avoid high percentage spirits and remember, the less the better! You may be toasting to ill health with that glass of wine. Say no to false advertising of the wine industry! Your body will thank you for it.

More information on alcoholism: http://nethealthbook.com/drug-addiction/alcoholism/

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Feb
05
2013

News About Your Heart Health

Introduction

Notably, this article is regarding news about your heart health. Specifically, February is heart month every year. So I thought why not review what is new regarding heart health in the last 15 years. In addition, this review also puts all the facts into perspective. I will start with a review of the older teaching about heart disease. First thing to remember, there was a paradigm shift in medical thinking. I will explain how this has changed the approach to heart disease prevention. The anatomy of the heart including coronary arteries and the heart valves has not changed over the years. The heart has always been at the center of life and will remain there.

A heart attack can develop from closing of one of the coronary arteries

It used to be thought that when a person ages one should expect to get problems with high cholesterol, which would be the cause of hardening of coronary arteries of the heart until one day the person would experience a heart attack from the closing of one or more of the three coronary arteries. Certainly, cardiologists can then offer an arteriogram, place a stent to reopen any blocked coronary artery and the patient would be OK for another 5 to 10 years. Alternatively, coronary bypass surgery can be offered by a cardiovascular surgeon to revascularize the coronary arteries.

Apart from cholesterol patients can get heart attacks from chronic inflammation

In contrast, in the mid 1990’s all this changed with the realization that 50% of heart attacks happened in patients who had normal cholesterol levels. In fact, research showed that inflammation of the heart vessels starts the process of subsequent blockage that causes heart attacks. A great deal of research in animal models and with humans took place. Indeed, this showed that a lot can be done in the area of prevention of heart attacks. Cure rates can only change very little when damage to the heart muscle has already occurred. The paradigm shift is in the understanding of what leads to a heart attack.

Too much sugar, starchy food and fat cause inflammation of the coronary arteries

We now know that too much sugar, too many starchy foods and too much animal fat will lead to inflammation of the arteries including the coronary arteries. The reason is that faulty nutrition leads to a lack of omega-3 fatty acids and a surplus of omega-6 fatty acids. This starts the inflammatory cycle, which causes inflammation in the arterial walls. Rising LDL cholesterol levels (that’s the bad cholesterol) follow and HDL cholesterol levels (that’s the good cholesterol) fall.

Nitric oxide production necessary to keep coronary arteries open

Associated with this is a lowering of nitric oxide production in the lining of the arterial walls, which leads to a narrowing of the arterial opening and simultaneous development of high blood pressure. Research of the metabolism of cells, particularly the subunits of cells called mitochondria, shed a new light on the heart as well. Mitochondria are the energy producing subunits of the cells. They are abundantly present in those organs that have a high metabolism. These organs are the heart, brain, liver and kidneys.

News About Your Heart Health

News About Your Heart Health

Life prolonging steps to prevent heart attacks

This newer knowledge allows the prevention-oriented physician to help patients not to get heart disease on the first place. The key is to prevent inflammation of the arteries and to add nitric oxide as a supplement. Also, the physician wants to change the food composition that the patient consumes. In addition, the physician wants to  intervene at the mitochondrial level. The patient achieves this with the help of supplements and by a regular exercise program. Over the years there have been impressive clinical trials that show that these preventative means when taken together can add 10 to 20 years of productive life without any disability. In the following I am going to describe the rationale for each of these life-prolonging steps:

Preventing inflammation of the arteries

Preventing inflammation of the arteries: at the moment many people eat the standard North American diet consisting of foods with too much sugar, processed foods with animal fat and lots of pasta. People need to eat a lot of leafy-green vegetables (kale, spinach, Swiss chard) and lean pork, turkey and chicken.  this will change the omega-3 to omega-6 ratio in favor of omega-3 fatty acids. This has a powerful effect on your body, as the surplus omega-3 fatty acids will suppress any inflammation in your blood vessels, which prevents heart attacks.

Eat organic foods

If you also eat as much organic food as possible, you will in addition reduce the toxic load in your body from heavy metals like lead and mercury and chemicals like herbicides and insecticides that often are contained in regular non-organic foods. By cutting out sugar and refined carbohydrates fasting insulin levels and triglyceride levels fall. This prevents diabetes and keeps your arteries open longer.

Adding nitric oxide and doing intermittent chelation therapy

By adding nitric oxide as a supplement such as “Neo40” (this supplement has hawthorn and red beet extract in it) the lining of the arteries gets a boost of nitric oxide production.  This lowers your blood pressure and widens the arteries in your body including the coronary arteries. The result is more oxygen and nutrients for your heart cells. By intervening at the mitochondrial level with the help of supplements and by doing occasional intravenous chelation therapyto remove heavy metals you can revive the sluggish metabolism of the mitochondria of your major organs. It’s like you are recharging the battery of your car, just here we are dealing with the microscopic energy packages, the mitochondria, in the cells of your vital organs including your heart.

Life prolonging supplements

Certain vitamins and supplements help in this process as follows: D-ribose, alpha-lipoic acid and CoQ10 support mitochondria; niacin lowers triglycerides and LDL cholesterol and elevates HDL-cholesterol (the good cholesterol); magnesium is an important cofactor of many enzymatic reactions in your cells and it also lowers blood pressure by widening the arteries making it easier for your heart to pump blood through them. Omega-3 and vitamin D3 both are anti-inflammatories, which makes these two important supplements for heart attack prevention. Vitamin D3 is also important for your immune system and helps to absorb calcium from the gut. Vitamin K2 has been found to be important to help transport the calcium into your bones preventing osteoporosis, so that it does not stay in your vascular system and cause hardening of your arteries by getting into your arterial walls.

Bioidentical hormone replacement

Bio-identical hormone replacement therapy is a powerful stimulus for the metabolism of your whole body, but particularly your heart. The heart needs adequate amounts of thyroid hormones and sex hormones (testosterone in males, balanced estrogen and progesterone in females). DHEA is a precursor hormone from your adrenal glands that your hormone balance requires for support of your heart muscle. The physician can order hormone tests and replace what is missing with bio-identical hormones.

Regular exercise program

A regular exercise program rounds up your heart support program. A regular exercise program by itself has been shown to be powerful heart attack prevention by cutting heart attack rates into half when compared to a non-exercise control group. Exercise builds up your heart muscle reserves and prevents clogging up of coronary arteries.

Lifestyle changes

Lifestyle changes can have a powerful effect in terms of preventing heart attacks. Everybody knows that those who smoke will not live as long as those who don’t. Smoking accelerates hardening of the arteries and causes not only heart attacks, but also cancer. Perhaps less known is the fact that alcohol can poison mitochondria. The fact that wine contains bioflavonoids is what prevents heart attacks.  Statistics show that 1 glass of wine for women and two glasses of wine for men prolong life. The wine industry was quick to exploit these statistics for the benefit of their sales. Fact is that even small doses of alcohol are a cell poison. Bioflavonoids are much more effective when taken as part of your daily supplements (resveratrol capsules) and it is much healthier for your heart and other body parts, if you do not consume any alcohol at all.

Apart from the Framingham Heart Study what we know

Originally the Framingham study showed that high LDL cholesterol was associated with heart attacks. But now we know that it is the overconsumption of sugar, high fructose corn syrup and refined carbohydrates in processed foods as well as animal fat overconsumption (mostly omega-6 fatty acids) that lead to inflammation of the lining of the arteries including LDL cholesterol overproduction from the liver. The focus has switched from lowering cholesterol and triglycerides to reducing and preventing inflammation and to supporting the mitochondria of the heart muscle cells.

Preventing 85% of heart attacks

Simple steps as outlined above have the power to prevent about 85% or more of heart attacks. They work by treating insulin resistance through the diet changes, which in turn lowers fasting insulin levels, blood sugars and triglycerides as well as cholesterol. Inflammation is kept at bay. You prevent heart disease and in addition also arthritis, high blood pressure, strokes and Alzheimer’s disease. One of the side effects is weight loss, extra energy and a sense of wellbeing.

More information on heart disease: http://nethealthbook.com/cardiovascular-disease/heart-disease/

Jan
22
2013

Long-Term Multistep Weight Management

In February of 2001 my wife and I attended an anti-aging conference in San Diego. The keynote speaker was Dr. Barry Sears who is the inventor of the zone diet. We had read a book from him before the conference and were excited to hear him speak in person. We liked the book; we liked the talk, so we cut out sugar, starchy foods and stuck to a diet where the calories derived 50% from low-glycemic, complex carbohydrates, 25-30% from lean meat, poultry and fish. Calories derived from fat were reduced to about 15-20% (there is hidden fat even in lean meat). No butter, but instead some lean cheeses and olive oil for cooking and in salad dressings. We shed both 50 pounds within 3 months without any hunger pangs. Our energy increased and this has stayed  this way ever since. There was no problem getting down with our BMI’s (body mass index) to 23.5 or 24.0, which is usually viewed as normal by the medical profession. We noticed, however, that when we did not exercise, there was a problem maintaining our normal weight.  We are under the care of an anti-aging physician who did special tests like fasting insulin, C- reactive protein, and hormone tests. They were all normal. We took up ballroom dancing really seriously having been inspired by “Dancing With the Stars”. This was 6 years ago. What started innocently with only a few basic ballroom lessons three times per week has now blossomed into dancing more than 10 different dance styles 5 times per week.

Long-term Multistep Weight Management

Long-term Multistep Weight Management

3 ½ years ago both of our energy levels were slowly going down, particularly after a long night of dancing. Hormone tests revealed the initial stages of age-related hormone deficiencies which did not come as a surprise , as  decreasing hormone levels was a topic discussed  in detail at the conference in San Diego in 2001 (we also attended several other anti-aging conferences on a yearly basis from 2009 onwards). With bioidentical hormone replacements these levels normalized within one year, our energy was back and our weight stayed normal. We enjoy travelling, but there can be problems with our multistep weight management program. We need to watch our diet (no toxins, preferably only organic food), and physical exercise may be less regimented. In 2008 we read Suzanne Somers’ book “Breakthrough”. We ordered urine tests for toxic metals and we were shocked that we had noticeable levels of mercury and lead. Since then we started to cut our salmon consumption from 3 to 4 times per week down to once or twice per week. To get rid of the heavy metals we started intravenous chelation treatments with vitamin C (10 Gm) and Glutathione (1250 mg) every two weeks. In July 2012 there were reports of radioactive salmon from the Japan nuclear disaster earlier that year in the Canadian media. After this news we stopped eating all fish and other seafood, not only because of radioactivity, but also because of other toxins like mercury, cadmium, PBC’s etc.  We do take high doses of molecularly distilled omega-3 fatty acids along with our other supplements. We also started eating mostly organic foods as we do not want to ingest insecticides, herbicides and other toxins.

We acquired body composition scales, which give information about fat percentage including visceral fat percentage, muscle mass percentage, BMI, weight and the basic metabolic rate. We wanted to define the end point of what our ideal body weight would be. We noticed that our dance program was not good enough to lower the BMI below about 23.5; using the body composition scales we noted that our body fat content was still too high and the visceral fat percentage was still in the 6% range. It took a prolonged trip to the US where we could not find enough dance events to decide that we would introduce a one hour gym program consisting of 30 minutes of treadmill, 15 minutes of upper body circuits, and 15 minutes of lower body circuits every day as a basis to our exercise program. Any dance activity would be just an additional exercise on top of the base exercise from the gym. It took only about 2 months before our fat composition decreased, our muscle mass increased, the visceral fat went to a normal at 5% and the BMI was now stabilized at the 21.5 to 22.0 range. We feel a lot more confident in managing our weight long-term without really thinking much about the weight. It is now a routine we follow, like an athlete would do to stay in shape. While nobody has a permanent guarantee to everlasting health, we do it to prevent the diseases we do not need in our retirement like diabetes, arthritis, heart attacks, strokes, cancer or Alzheimer’s.

What we did not know until after the 20th A4M Anti-Aging Conference in Las Vegas (mid December 2012) was that inadvertently we were protected from exposure to chemically modified wheat from 2001 onwards as we had cut out all refined carbohydrates and starchy foods (including wheat) since then. Unfortunately many Americans still expose themselves unknowingly to larger or smaller quantities of wheat, suffer from leaky gut syndrome with the associated changes in the immune system and the development of autoimmune diseases.

Personally, I believe that long term weight management is possible: you can turn older and hopefully wiser…not wider. The good news: it can be done. The bad news: this is not an instant fix, but a program that needs to be part of your lifestyle package.

More information on weight loss: http://nethealthbook.com/health-nutrition-and-fitness/weight-loss-and-diet/

Last updated Nov. 6, 2014