Nov
25
2014

Gluten Intolerance Or Food Sensitivities?

A report about gluten free food is circulating in the media based on this publication. It points out that gluten-free food is not as healthy as the companies want you to believe it to be.

Wheat is the source of gluten, so rice, potato, corn and sugar are used to replace wheat. Corn is deficient in niacin leading to B3 deficiency; and the amino acids lysine and tryptophan (missing in corn) are needed for production of serotonin in the brain, which prevents you from getting depressed.

The reference cited above points out that rice can be contaminated with arsenic, which is a toxin.

Gluten-free food is a special form of processed food. Any processed food is not as good as natural food that you buy from the periphery of the grocery store.

So, what do we know about gluten sensitivity?

Causes of increased diagnosis of gluten sensitivity

Only 1% of people are gluten sensitive at this point. Just 30 years ago this number was 0.025%. 10 years ago 0.04% of people were thought to have gluten sensitivity. The difference may be due to improved sensitivity of the testing methods. But another factor is the new wheat, called Clearfield wheat, which was obtained through chemically forced hybridization of wheat resulting in significant genetic modifications from the original wheat. This type of wheat is now grown all over the world. As I explain in this blog Clearfield wheat has a significantly higher percentage of gluten, which likely contributes to the increased gluten sensitivity in the population at large and particularly among patients with irritable bowel syndrome (IBS).

Irritable bowel syndrome and other food sensitivities

According to Ref. 1 among patients with irritable bowel syndrome (IBS) 4 to 5% have true gluten intolerance (celiac disease). In the general population (without IBS) the gluten sensitivity percentage is less than ¼ of that. On the other hand lactose intolerance in the US is found in 25% of all adults and in 35% to 45% of IBS patients. Another common food sensitivity is fructose and sorbitol intolerance, which occurs in about 40% of patients with IBS and about the same percentage in non-IBS controls. This means that if you leave out sorbitol and fructose, about 40% of people will find relief from abdominal cramps or bloating. A common item that people chew on, according to Ref.1 is sorbitol-containing chewing gum. If this type of chewing gum is eliminated, 40% of people will feel better in their gut. So, keep in mind that the majority of people with food sensitivities do not have gluten sensitivity, but lactose intolerance and allergies to fructose and sorbitol.

Other manifestations of celiac disease

Celiac disease is not only a disease that manifests itself in a skin rash (as originally described in celiac patients). It is responsible for a significant amount of ADHD (attention deficit hyperactivity syndrome) or ADD (attention deficit syndrome) and can even cause Parkinson’s disease. It stands to reason that these conditions can be improved with an appropriate diet.

 

Gluten Intolerance Or Food Sensitivities?

Gluten Intolerance Or Food Sensitivities?

Gluten-free foods often contain problematic replacements

When you go to a grocery store or health food store and look at their gluten free shelves, they offer you an array of products like gluten-free bread and bakery items, cereals, cookies, pastas and many other processed foods. As explained above wheat is the main source of gluten and when you replace it, the substitutes are rice, tapioca starch, quinoa, potato, corn and sugar. We already pointed out some deficiencies of corn. There are also concerns of toxicities as in rice, particularly if it comes from imported material (arsenic). As the majority of people with food sensitivities are allergic to milk sugar (lactose), fructose and sorbitol, these items have to be screened carefully by reading all of the details on the food labels of the products. If you suspect other food allergies, see your primary care physician doctor for testing to these allergens and also have several of the gluten sensitivity tests done. If the gluten sensitivity tests are all negative, you only need to pay attention to milk sugar, fructose and sorbitol, particularly, if you have been diagnosed with IBS.

Hidden sugar and starch content of gluten-free food

What has not been mentioned so far is the sugar and starch content, which eventually leads to higher calories. Sugar is easy to spot on the food label as this is usually listed clearly. I stopped buying dark chocolate, even the 85% variety as they are selling me 10 grams of sugar in a 40 gram helping (25% of sugar). All the health benefits are no longer applicable when you consume that much sugar with a supposedly healthy food item. So add up the sugar you are getting and add up the calories you are seeing listed. Usually, if the sugar content is high, the calories are high.

As an example, when you research on Google regarding gluten-free corn chips, the food content of a typical product is listed as follows: 12 chips (28 g) contain 0 g glucose, 7 g fat, 14 g carbohydrate, 4 g protein, 100 mg sodium and 250 mg of potassium. It also lists that the total calories are 140, of which fat contributed to it 60 calories. 78% of the 80 calories left (namely 62.4 calories) came from the carbohydrate (starch in corn) and 22% of the remaining calories were protein derived (this I had to calculate). As the stomach digests the corn chips within half an hour into sugar, you really have eaten 62.4 calories from sugar. The Internet tells you that 2.3 g of sugar from a sugar cube are the equivalent of 9 calories. Our “sugar math” can be completed by doing this: 62.4 / 9 x 2.3 g = 15.94 or 16 grams of sugar. So, the food industry actually lied to you by saying that there was 0 g sugar in the 12 corn chips. What happened is that your body digested the 14 grams of carbohydrates and converted it into sugar, which was absorbed into your blood stream. Your pancreas could tell you a story, because it had to produce insulin to keep your blood sugar level in balance!

You may wonder how I solved the dark chocolate problem, which by the way would double as a gluten-free food: You buy 100 % unsweetened Baker’s chocolate (0 g sugar on the label) and liquefy it in a little bowl in a pot with hot water. Add a tiny bit of stevia sweetener and add a tiny bit of vanilla extract into the well-stirred chocolate liquid. Prepare a form out of aluminum foil with a rim. Pour the content carefully into this (watch it, hot!) and let it sit to cool down. When it is at room temperature, cut into smaller pieces, which you keep in a glass jar. This is 100% gluten-free chocolate, 100% chocolate and 100% healthy.

Conclusion

Not all is well in the gluten grocery row of your friendly super market. There are problems in that 20 to 25% of people believe they may have gluten sensitivity when in reality only 1% have it. But the majority of people have not done a gluten-screening test, which would confirm that they have indeed celiac disease. As pointed out above, it is much more likely that a food sensitivity may be caused by another offending agent rather than gluten (milk sugar, fructose and sorbitol). Avoiding the offending food components is the treatment protocol.

Those who take in gluten-free food will expose themselves to unnecessary toxins, to extra sugar leading to obesity and metabolic syndrome that leads to premature heart attacks and strokes. For those who do need to be on a strict gluten-free diet, they can safely do so by following a strict gluten free diet at home (preparing your own meals from healthy ingredients), preferably with organic foods. There are many websites that you can find online that have meal suggestions.

More information about celiac disease.

References:

1. Rakel: Integrative Medicine, 3rd ed. Patrick J. Hanaway, MD: “Chapter40: Irritable Bowel Syndrome. Integrative Therapy”. Copyright 2012 Saunders, An Imprint of Elsevier

Last edited Nov. 25, 2014

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Nov
02
2013

MS Is A Multifaceted Disease

A new study was recently released that showed that MS is a multifaceted disease. A significant number of people without multiple sclerosis have narrowing of their neck veins. There is a new theory that chronic cerebrospinal venous insufficiency due to narrowing of veins outside the skull may be responsible in causing MS in a significant percentage of patients. Using venograms in MS patients and in controls without MS a recent study from the University of British Columbia, Vancouver, BC showed that normal controls also had narrowing of neck veins and the authors felt that this invalidated the vascular theory of MS. This story is based on this Lancet publication.

Brain oxygenation is what counts

What was not mentioned in this publication was that venous blood flow on the surface of the brain can get obstructed inside the skull. It’s all about brain tissue oxygenation; if the brain gets enough oxygen, all is well. If there were a lack of perfusion due to venous congestion inside or outside the skull, the patient would be in trouble.  I will discuss this further below.

In this blog I will discuss first how to diagnose MS, then mention some newer studies about neck vein circulation with SPECT scanning. I will then review various causes of MS and return to a discussion of the Vancouver study from above.

How MS is diagnosed

The physician can combine a number of tests to diagnose MS. This includes the patient’s symptoms such as balancing problems, double vision, memory problems, fatigue etc. Neurological examination, imaging studies like MRI scanning, lumbar puncture to examine the cerebrospinal fluid and evoked potential studies is what a neurologist orders. The physician requires all of these findings to decide whether the criteria for making a diagnosis are in keeping with all the symptoms of MS. In 2001 an international neurological panel developed the McDonald criteria for diagnosing MS, which were revised in 2010.

MS Is A Multifaceted Disease

MS Is A Multifaceted Disease

Newer ways diagnosing perfusion problems in MS patients (SPECT scan)

One of the newer functional scans is a SPECT scan. It shows areas where there is a lack of blood supply to the brain, but can also identify areas where too much blood circulates. Here is a site where the technique of the SPECT scan is reviewed in more detail.

SPECT scan results in MS patients

SPECT scans in MS patients showed a significant reduction in blood flow to the frontal lobes and to the left temporal lobe. Reduced activity of the left temporal lobe on SPECT scans correlated with MS patients having a deficit in verbal fluency and having a problem with verbal memory. This indicates that a reduction in blood flow to these areas of the brain associates with developing MS.

Perhaps a SPECT scan of the brain (which is where the action of MS is) may be a better indicator for MS than looking for veins in the neck by ultrasound or venograms, as SPECT scans look directly at brain perfusion. The question is whether these blood circulation problems in MS patients may cause deficiencies in the brain of oxygen, nutrients and possibly of other internal mediators.

Known causes of MS

There are a number of known causes of MS, which I will review below.

Autoimmune disease

As this link shows, MS is a disease due to inflammation of the brain. The area where there is inflammation leads to demyelination from loss of the myelin sheaths, which causes the white lesions visible on MRI scans of the brain. One such cause is an allergy to wheat and wheat products. Gliadin antibodies and anti-tissue transglutaminase antibodies were positive in a significant number of MS patients, but not in controls. This suggests at least in part that immunological causes are at play. I agree with this blog that describes that there is significant evidence that gluten intolerance can lead to MS and the positive tests that were found by researchers are likely just the tip of the iceberg.

Overlap of celiac disease and MS

Dr. William Davis describes in Ref. 1 and 2 that you can have celiac disease with no gut symptoms, in other words a person can develop autoimmune symptoms from gliadin and gluten sensitivity without diarrhea or bowel cramps. Dietary lectins, particularly the ones found in wheat lead to leaky gut syndrome and subsequently to autoimmune diseases. One of these autoantibodies can cause MS by destroying the myelin sheath. In a mouse model Mayo Clinic researchers have shown that an antibody injection can be used to block autoantibodies against the myelin sheath. Investigations are ongoing with regard to whether this type of treatment would work in humans as well.

Genetic factors

It is known that a human leukocyte antigen (HLA -DRB1) shows an association with the risk for developing MS. Caucasians have a higher risk of developing MS and they also carry the HLA-DRB1 antigen more often. Another genetic factor is a variation of the IL7R gene. You can read about it under the HLA-DRB1 link. On average the risk of getting MS in the general population is about 10 to 20%.

Nutrition and dietary factors

It has been described that vitamin D3 levels when obtained from in MS patients are low. Vitamin D3 can prevent against MS to a certain degree, so does sun exposure. In countries where malnutrition is common, MS occurs more often.

According to Dr. Terry Wahls who is a clinical professor of medicine at the University of Iowa Carver College of Medicine, a diet of vegetables, fruit, meat, no grain, no dairy, no sugar, no corn and no potatoes can cure MS. Dr. Wahls herself had severe MS in the past and cured it with the help of this diet!

Infections

Certain infections can cause MS. Probably the best correlation was found between the mononucleosis virus (Epstein Barr virus) and the later development of MS.

Chronic cerebrospinal venous insufficiency

According to Dr. Zamboni from Italy clogged veins in the neck can cause MS. Dr. Zamboni placed stents into neck veins that showed narrowing.  He found that about 50% of MS patients had improvement with the placement of stents. This allows the blood from veins around the brain to drain normally. This could improve brain circulation in the areas described above where SPECT scans detected a lack of blood supply to certain parts of the brain.

Discussion of the Vancouver publication

It is important to note that certain areas of the brain were not circulating blood as well as others. SPECT scans depicted the blood circulation of the brain. 50% of patients with chronic cerebrospinal venous insufficiency experienced a cure from MS with simple venous stent procedures. This is remarkable. Sure, the Vancouver researchers found that normal controls also have a significant amount of venous abnormalities in their necks. But this does not explain the successes in those MS patients who got better with a simple venous stunt procedure. We also need to be cognizant that Big Pharma sponsored the Vancouver study researchers.

Measuring brain circulation in MS patients

SPECT scans on both the control groups and the experimental MS groups before and after stent procedures need to be done. This way we know whether the brain circulation following stent procedures improved or not. However, this is what I would have expected to see. In other words more research is necessary by other investigators. The question they need to answer is whether or not the surgical stents provided help. Did the surgical procedure help to normalize their brain circulation or not?

Conclusion

Our knowledge regarding MS is getting more multifaceted as new research is emerging. Diet appears to be a major contributing factor, as vitamin D3 is essential for normal brain function and for a normal immune system. At the same time researchers identified grains and wheat as a cause of MS in a subgroup of patients. Leaky gut syndrome can cause autoimmune antibodies, which subsequently can bring on MS. Avoid the foods Dr. Wahls described as being causative in developing MS and you can improve MS remarkably or get cured. The same is true for avoidance of wheat and wheat products as Dr. Davis described.

Multifaceted causes of MS

In my opinion not every MS patient benefits from a stent, but vitamin D3 deficiency or a history of mononucleosis infection in the past does not explain the causation of every MS case. We simply do not have all of the answers yet. But we do have enough information to thoroughly investigate MS patients;  the treating physician will then use clinical judgment to decide which treatment would be the most suitable one for an individual MS patient.

More information on multiple sclerosis: http://nethealthbook.com/neurology-neurological-disease/multiple-sclerosis/

References

1. Stern: Massachusetts General Hospital Comprehensive Clinical Psychiatry, 1st ed. “DSM-IV SUBTYPES OF MDD”. Copyright © 2008 Mosby

2.  William Davis, MD: “Wheat Belly. Lose the Wheat, Lose the Weight, and Find Your Path Back to Health”. HarperCollins Publishers LTD., Toronto, Canada, 2011.

3.  William Davis, MD: “Wheat Belly Cookbook. 150 Recipes to Help You Lose the Wheat, Lose the Weight, and Find Your Path Back to Health”. HarperCollins Publishers LTD., Toronto, Canada, 2012.

Last edited Nov. 7, 2014