Feb
15
2014

Melatonin More Than A Sleeping Aid

By | Anti-aging medicine, Cancer, Health, Hormones, Insomnia, Prevention, Vitamins and supplements

Melatonin has been available to the public in the US since 1992. It is usually used as a sleeping aid or for jet lag related sleeping problems. However, in the last decade much more data about melatonin has come out that has proven that melatonin is a major hormone. The pineal gland contains another brain hormone, serotonin, which is converted into melatonin within that gland. Melatonin is a key hormone that regulates the sleep/wake cycle. It works in concert with cortisol, which has the highest level in the morning while melatonin has its highest level in the evening and during the night. Melatonin also regulates the menstrual cycle and determines when women get into menopause.

Lately new information has come to the forefront showing that there are connections to Alzheimer’s disease, Parkinson’s disease, stroke size and recovery from strokes. Even traumatic brain injury can be minimized when enough melatonin is present. In addition melatonin is an important anti-oxidant.

Finally, there is evidence that melatonin helps to determine how well we age.

In the following I like to review some of the evidence for all of these claims.

1. Melatonin as a hormone

Melatonin levels were found to be very low in breast cancer and prostate cancer patients. It has been determined that the immune cells have melatonin hormone receptors and need melatonin for stimulation. Because of the immune stimulatory effect of melatonin, it is often given as a cancer adjuvant treatment to other cancer treating modalities. Ref. 1 describes that melatonin regulates the female hormones (LH, FSH), which then determine when a woman has her menstrual period and also when she eventually enters menopause. The pineal gland is the master gland for the diurnal hormone rhythms.

Melatonin More Than A Sleeping Aid

Melatonin More Than A Sleeping Aid

2. Melatonin levels decline with age

Melatonin levels in both men and women decline as we age. This figure shows that the highest melatonin levels are reached by the age of 10; by the age of 40 only 15% of the youthful levels remain while by the age of 55 only 5% or less of the original youthful levels are left. This explains why older people are more prone to infections (missing immune stimulation) and why the sleep pattern in older people is changed (shorter periods of sleep, less restful sleep). Ref. 1 points out that with insulin resistance (from diabetes or due to excessive sugar and starch consumption) cortisol levels are chronically elevated, which in turn inhibits melatonin production.

3. Melatonin protects from neurodegenerative diseases

A newer application of melatonin is as a preventative in the neurological field, particularly in the area of Alzheimer’s disease, Parkinson’s disease and the prevention of strokes. With respect to Alzheimer’s disease studies have shown that patients with Alzheimer’s have much lower melatonin blood levels when compared to age matched normal controls. In ischemic stroke patients it was found that stroke patients had much lower melatonin levels when compared to normal age-matched controls. Other studies have shown that pineal gland calcification was associated with low melatonin levels and a high risk for ischemic stroke. This risk was even higher when the patients had high blood pressure, diabetes and high cholesterol/triglycerides. When a stroke has occurred, it is important that the free radicals are removed as quickly as possible, which is where the antioxidant properties of melatonin fit into a rehabilitative program. The presence of melatonin enhances brain plasticity. However instead of using melatonin after a stroke, it is much better to use melatonin regularly before a possible stroke, as this gives a better chance reducing the size of the stroke. This in turn will lead to a faster and more complete recovery after a stroke.

Another important disease of the elderly is Parkinson’s disease. Melatonin helps to prevent oxidative damage to the dopamine producing cells in the basal ganglia thus preventing Parkinson’s disease. As with Alzheimer’s disease, there is a correlation of low melatonin levels and this neurodegenerative disease, which goes beyond the age-related reduction of melatonin levels. In experimental Parkinson’s disease models in mice melatonin was highly effective in preventing deterioration of Parkinson’s disease.

4. Melatonin may extend life

The combination of being a free radical scavenger, an immunostimulant and an integral key hormone allow melatonin to have beneficial effects in the aging process. When melatonin supplements are given, the stimulation of the immune system can cut down infection rates in the elderly, prevent and mitigate degenerative diseases of the brain (Alzheimer’s, Parkinson’s), re-establish sleep/waking rhythms and help reduce arthritis.

Conclusion

Melatonin is a widely used sleep aid. As it is practically absent in people beyond the age of 55, it makes sense to supplement with melatonin in that patient group. However, there are side effects particularly in people on blood thinners as coumadin competes with melatonin in getting eliminated through the cytochrome P450 liver enzyme system. This will result in longer bleeding times in patients on blood thinners who also take melatonin supplements. It is important that patients discuss this with their doctors. However, given all of the benefits described above, for the vast majority of the baby boomers melatonin supplementation would be very beneficial. Doses as a sleep aid vary between 1mg and 5mg at bedtime for most people. Cancer patients require higher doses (10 to 20 mg per day).

More information on melatonin, which is at the center of the circadian hormone rhythm as the key hormone switching from day to night and welcoming the day by switching its secretion from the pineal gland off in the morning: https://www.askdrray.com/how-to-cope-with-time-switches/

Reference

1. Datis Kharrazian: “Why isn’t my brain working?” Copyright 2013, Elephant Press, Carlsbad, CA, USA (pages 306-310).

Last edited Nov. 7, 2014

May
11
2013

Changes Of Gut Bacteria Can Cause Heart Attacks

By | Cancer, Health, heart attack, Heart Disease, Prevention, Stroke, Vitamins and supplements

The recent news of gut bacteria possibly being involved in causing heart attacks (see details below) sounds pretty outrageous. In order to make this more understandable, we need to start backtracking how bacteria end up in our gut and what they are doing there.

Gut bacteria in our bowels at various stages in life

Even among infants there is a huge difference in the composition of the gut flora depending on whether the baby was vaginally delivered, born by Cesarean section or prematurely born and nursed in an intensive care unit for a prolonged period of time.

When we are grown up, it depends on where we live on our planet as to what type of gut flora we have. A 2011 study of the bacterial composition of stool samples in Europe versus Africa showed that the European microbiome in the colon was typical of the Bacteroides enterotype, whereas the African microbiome was dominated by the Prevotella enterotype. Other studies have shown that the type of diet we eat causes us to harbor different types of gut flora. A person eating a more vegetarian diet will have a Prevotella enterotype gut flora, while another person eating a Western style fat and protein dominated diet will have a Bacteroides enterotype gut flora. What is the gut flora doing? It lives within our gut for our mutual benefit. We provide the gut bacteria a comfortable home at body temperature where they grow best. They in turn ferment undigested foods, protect us from the growth of harmful bacteria, produce vitamins like vitamin K and biotin, and produce hormones that direct the body to store excess food as fat.

Changes Of Gut Bacteria Can Cause Heart Attacks

Changes Of Gut Bacteria Can Cause Heart Attacks

Cleveland Clinic’s gut flora research linked to heart attacks

In April 2013 reports that heart attacks may be related to the composition of your gut flora hit the popular press, articles like this. Two years earlier, in April of 2011, the same Cleveland research group under Dr. Stanley Hazen found that the gut flora composition has an impact on heart disease. They stated that a “byproduct called trimethylamine N-oxide (TMAO) is produced when intestinal bacteria digest the nutrient phosphatidylcholine, commonly known as lecithin”. It was determined that the liver was responsible for producing TMAO out of absorbed materials from gut bacteria and that this was responsible for accelerating hardening of the arteries, which in turn caused deadly heart attacks and strokes.

As can be seen from this link the Cleveland research group is suggesting that TMAO could become a valuable screening tool when measured in patients’ blood to screen for their risk to develop a heart attack or stroke in the future. Furthermore, once these patients are identified, they can be sent to a dietitian and be put on a different diet that prevents heart attacks and strokes; also, the progress could again be monitored through repeat TMAO blood tests down the road.

Criticism of research from the Cleveland Clinic

Not every one has welcomed the study as clear-cut proof for a link between the gut flora and heart attacks, strokes and deaths. This link shows that it is questioned whether perhaps low antibiotic residues in red meat would explain the findings of the study. It rightly points out that there was no control for whether the more than 4000 patients were eating organic foods or a regular American diet. The comment goes on to say that the regular American diet contains residual antibiotics from milk, milk products, beef, chicken and turkey. These traces of antibiotics are powerful enough to have an effect on the gut flora, which likely is the reason for the differences between the vegetarian diet versus a Western style fat and protein dominated diet. It is entirely possible that grass fed beef would not lead to TMAO levels in the blood whereas regular beef or hamburger meat will raise the TMAO levels. The same could be true for egg consumption, which was also accused of raising TMAO levels. However, we do not know whether organic eggs that do not contain antibiotics would have done the same as regular eggs that contain traces of antibiotics.

Cancer caused by gut flora

This 2008 review article explains how lactobacillus and bifidobacteria (probiotics) prevent colon cancer, while bacteria of the Bacteroides and Clostridium variety increase the incidence of colon cancer and the growth rate of colonic tumors. So, the composition of your gut flora does not only matter with regard to prevention of heart attacks and strokes, but is also important in preventing colon cancer.

Change your gut flora to boost your health

Here is where the “rubber hits the road”. What I mean is that you can benefit from all of this research with regard to your health by paying attention to a few facts and possibly making a few changes as follows.

  1. I think that the argument of the bulletproofexec.com website holds true and we should all eat organic meats whenever possible. The Cleveland study has already shown that the gut flora in vegetarians stayed healthy even when they occasionally slipped and ate a regular steak.
  2. Take supplemental probiotics from the health food store. It will improve your gut flora within a day or two.
  3. Higher intake of fruit and vegetables make a measurable difference in the body decreasing the risk for heart attacks and strokes as this British research group has shown. Another research group from Italy has confirmed that an increased intake of fruit and vegetables mobilizes genetic switches that will stabilize the metabolism of the gut wall and prevent cancer of the colon.

So, the verdict for boosting your health is out: eat organic foods, use probiotics as supplements and eat more fruit and vegetables!

More information on nutrition: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/

References

  1. http://www.nature.com/nm/journal/v19/n5/full/nm.3145.html
  2. http://www.ncbi.nlm.nih.gov/pubmed/23614584

Last edited Nov. 7, 2014

Jul
01
2006

Better Blood Pressure Control With New Drug

By | Heart Disease, High Blood Pressure, Prevention, Stroke

Numerous medications for blood pressure control are in circulation. Treatment of high blood pressure patients is crucial in the prevention of strokes, but despite the multitude of drugs that are on the market, the treatment has its challenges. Some of the drugs have side effects, like an irritating cough, and a suitable medication has to be tried out first. Even, when all is well and there are no unpleasant side effects, many patients have a problem with compliance. Pills that have to be taken several times per day are forgotten. As a result, the patient will have poor blood pressure control.
Blood pressures must be controlled on an ongoing basis. Ideally there are no big fluctuations, whether it is day or night. For this purpose, a medication has to stay in the system of the patient long enough. This time stretch is called the half-life of a drug.
The first drug in a new class of agents for the treatment of high blood pressure does exactly that: it has a long half-life, so blood pressure control is smooth and continuous, day or night. The oral direct renin inhibitor aliskiren has the potential to protect the heart and other organs with a once-daily dosage of 150 mg or 300 mg. The drug is being developed by Novartis, and clinical trials are on their way.
The medication in combination with a diuretic provides significant additional blood pressure reduction. The agent at work is a renin inhibitor (also known medically as “renin antagonist” as it blocks the effects of renin). In the past, renin inhibitors for treatment of hypertension (high blood pressure) could only be used as intravenous solution and this was only effective for a short time.

Better Blood Pressure Control With New Drug

Better Blood Pressure Control With New Drug

The new development is a breakthrough, as the medication is taken by mouth and it continues to work even when the drug is gone from the blood stream. It is ideal for daily dosing, and there is no apparent buildup in the body.

More information about hypertension (high blood pressure): http://nethealthbook.com/cardiovascular-disease/high-blood-pressure-hypertension/

Reference: The Medical Post, June 13, 2006, page 38

Comment on Nov. 13, 2012: Aliskiren  (brand name “Tekturna”) was approved by the FDA in March of 2007. However, as all drugs, it does have some side-effects like headaches, cough, angioedema, skin rash, elevated uric acid with gout etc. (see this Wikipedia link).

Last edited Nov. 1, 2014