May
15
2021

Research about Side Effects of the AstraZeneca Vaccine

Research about side effects of the AstraZeneca vaccine revealed some worrisome facts. An article that appeared in the German “Frankfurter Allgemeine Zeitung” explained that people should not worry about the vaccine.

The heading of the article was:” People no longer have to be afraid of the AstraZeneca-Vaccine.” But subsequently it describes how vaccinating with the AstraZeneca vaccine against Covid-19 developed blood clots in some people. Researchers at the University of Greifswald examined 7 cases where following the vaccine blood clots developed.  Dr. Andreas Greinacher is Head of the department of Transfusion Medicine in Greifswald, Germany. He said that blood clots are extremely rare following vaccinations. The 7 people who did form clots in sinuses (big vein structures) of the brain had all antibodies against platelets. Normally platelets help with hemostasis for wounds, but when specific antibodies bind to platelets, they can cause blood clots.

Research about side effects of the AstraZeneca vaccine identified blood clots as a problem

The Greifswald medical team said that they know how to treat this blood clot condition when it occurs. They are using blood clot dissolving medication like heparin and warfarin to dissolve the clots. But if this treatment is not instituted right away, the patient could get a stroke or pulmonary emboli, which is a life-threatening condition. Normal minor side effects of the vaccine occur on the first and second day after the vaccination. If blood clots appear in brain veins, symptoms of severe headaches develop on day 4 or 5 following the vaccination. Other patients might develop a painful leg due to a blood clot in the leg veins. If this should happen, the patient must present immediately at the emergency department of a hospital. Physicians will start anticoagulation therapy right away. The 7 patients who developed blood clots did so between day 5 and 14 following the AstraZeneca vaccination.

European decision to reinstate the AstraZeneca vaccine

The European Medical Agency stated that the benefits would outweigh the risks of the AstraZeneca vaccine. They recommended reinstatement of vaccinations with the vaccine. However, there remain problems with the vaccine. First, the effectiveness of the vaccine was initially determined to be 79%, but retesting showed it is only 76%. Next the Paul-Ehrlich-Institut that monitors complications of medical procedures in all of Germany determined 31 cases of blood clots. 9 patients died from them.

Interestingly, the EMA has reversed their opinion about the AstraZeneca vaccine on April 6, 2021 as can be seen from this press statement. Now they are saying that there is a clear association between the vaccine and rare blood clots in the brain.

In the US the CDC and FDA have not approved the AstraZeneca vaccine. The CDC also said that the Johnson-Johnson’s vaccine should be put on hold until a re-examination of the blood clot issue is clarified.

Discussion

The Pfizer and Moderna vaccines are pure RNA vaccines that are known to have very few complication rates. Researchers stated that only very few people develop clots in their brain or leg veins. They also stated that the majority of people benefit from the AstraZeneca vaccine. This is a simplification. There are other vaccines that doctors can use as alternatives that do not produce clots. It would be better to ask why there is clot formation with the AstraZeneca Vaccine!

The AstraZeneca vaccine contains a DNA adenovirus

The AstraZeneca vaccine contains remnants of a DNA virus, namely an adenovirus. Researchers added the gene for the coronavirus spike protein to the DNA adenovirus.

The DNA shell from the adenovirus helps to protect the vaccine at fridge temperatures, which increases the shelf life of the vaccine. But as with other DNA vaccines there are more complications possible. This question was reviewed here already 10 years ago.

In the end we are still faced with RNA vaccines against Coved-19 that work, versus a DNA vaccine that has possible complications with blood clots. I for one would not accept anything else but an RNA vaccine that does not have the clot formation side effect. I feel that the authorities should stop the AstraZeneca vaccine for now. The researchers should carry out further studies to see whether improvements can make the vaccine safer.

Research about Side Effects of the AstraZeneca Vaccine

Research about Side Effects of the AstraZeneca Vaccine

Conclusion

The AstraZeneca vaccine contains a deactivated DNA adenovirus. Researchers added the gene for the coronavirus spike protein to the adenovirus. This is a completely different approach from the RNA vaccines that do not have these side effects. The fact that some patients developed blood clots is likely explainable on the grounds that they received a DNA vaccine. In my opinion the authorities released the AstraZeneca vaccine prematurely. They should put a hold on this vaccine until scientists can develop improvements to the vaccine. In the meantime, people should receive the safer RNA vaccines.

To continue vaccinating with AstraZeneca vaccine is unacceptable

I disagree that governments allow a vaccine that has serious complication rates for which doctors offer anticoagulation therapy. It is only a matter of time that a few deaths occur, because the blood clots escaped diagnosis. The company has now renamed the vaccine as Vaxzevria. This seems to be a move of AstraZeneca to move away from the complications of the AstraZeneca vaccine. This does nothing to help solve the problem with the blood clots that don’t only occur “in a few cases”. We are dealing with a serious side effect, and you should ask yourself the question, whether it is worth the risk.

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Sep
05
2020

How to Manage Clot Formation with Covid-19

A publication in the Canadian Medical Association Journal describes how to manage clot formation with Covid-19. A significant amount of cases among Covid-19 patients come down with clotting problems. This means that an infection with SARS-CoV-2 (or Covid-19 coronavirus) may initially present with a fever and cough. But a few days later it can suddenly turn into a dangerous disease with severe clots, multiple organ failures and death.

Clot occurrence with Covid-19

It is important to realize that most patients with SARS-CoV-2 do not need hospitalization. But physicians admit 10 to 15% of patients to the hospital. Of these 20% end up with treatment in the Intensive Care Unit (ICU). Of all the hospitalized patients between 5% and 30% develop some form of thrombotic event. Notably, complications of clot formation can be a stroke, a heart attack, a pulmonary embolism or a deep vein thrombosis in the leg. In a recent study from the US 400 random hospitalized patients with Covid-19 144 patients were admitted to the ICU. 4.8% had radiologically confirmed deep vein thrombosis. Overall there were 9.5% with thrombotic events that developed during the hospital stay.

How does a coagulopathy develop with Covid-19?

Truly, SARS-CoV-2 enters the body cells through an interaction of its viral spike protein with the angiotensin-converting enzyme 2 (ACE2) receptor. To explain, numerous organs and tissues express this receptor. This includes lung alveolar type 2 epithelial cells, endothelium, the brain, heart and kidneys. To emphasize, ACE2 leads to angiotensin II degradation. With the SARS-CoV-2 stimulation of the ACE2 receptor there may be an accumulation of angiotensin II, which causes a procoagulant state. Injury of the endothelium explains inflammation in the lining of the blood vessels in multiple organs. Commonly affected organs are lungs, heart, kidneys and intestines. The inflammatory reaction is what can lead to clot formation. When part of an organ has died off because of mini clots that destroyed part of the organ, this process can eventually lead to organ failure. Lung failure, heart failure and kidney failure can develop in these sick patients.

Adequate vitamin D blood levels are important for the immune system

By all means, vitamin D is very important for the integrity of the immune system. With vitamin D blood levels below 15 to 20 ng/mL (37.5–50 nmol/L) the immune system is paralyzed, and any viral or bacterial infection tends to overwhelm the body. Of course, this is the reason why the mortality due to Covid-19 coronavirus is highest in patients with these low vitamin D blood levels. People with secondary illnesses (diabetes, arthritis, autoimmune diseases, cancer) and patients above the age of 60 have the lowest vitamin D blood levels and have the highest mortality rates. This publication describes this in more detail.

Best vitamin D blood level is in the upper normal range (50-80 ng/mL)

Above a vitamin D blood level of 30 ng/mL (=75 nmol/L) a patient’s immune system is functioning normally. However, the immune system is strongest at a vitamin D blood level of 50–80 ng/mL (125–200 nmol/L), which is the upper range of the normal level for vitamin D in the blood.

Keep in mind that vitamin D toxicity occurs only above 150 ng/mL (375 nmol/L).

Specific effects of vitamin D on Covid-19

There are three major effects that vitamin D has.

  1. A strengthening of the epithelial barrier not allowing the coronavirus to penetrate into the lung tissue as easily.
  2. Release of defensins and cathelicidin, two crucial antiviral polypeptides that eradicate any virus in the system.
  3. Interruption of the “cytokine storm”, an overwhelming inflammation which is responsible for viral pneumonia to develop. Without the cytokine storm there is no damage to the lungs and people do not need treatment in the ICU. This is particularly important for people above the age of 60 and for people with pre-existing diseases.

In like manner, with the stabilizing effect of vitamin D regarding the immune function more severe forms of Covid-19 can turn into less severe forms with a better outcome.

Treatment of patients with Covid-19 who have clotting problems

Patients need to be assessed with respect to their risk of developing clots. This publication describes that high risk patients have elevated D-dimer levels. When blood clots dissolve the body produces D-dimer, a protein fragment. Normally the D-dimer test is negative in a person that does not produce clots. But in sick patients with Covid-19 who form clots this blood test typically shows D-dimer >2500 ng/mL. In addition the tests show high platelet counts (more than 450 × 109/L), C-reactive protein (CRP) >100 mg/L and an erythrocyte sedimentation rate (ESR) >40 mm/h.

Indeed, with this constellation of blood tests in a severe Covid-19 case in the ICU setting, the physician uses heparin intravenously or subcutaneously to counter clot formation. However, this needs to be balanced against the risk of causing severe internal bleeding.

Separate from the anticoagulant effect, heparin seems to also suppress inflammatory cytokine levels. In addition, heparin suppresses neutrophil chemotaxis and migration. Physicians rescued many patients from death using heparin therapy.

Risk versus benefit clinical trials of heparin therapy are required

At this point there are only retrospective clinical trials available to describe risk versus benefit of heparin therapy. Some show no difference, others do. There are two international clinical trials on their way to shed more light on this situation. Until the results of these clinical trials are available, physicians need to treat patients to the best of their knowledge.

How to Manage Clot Formation with Covid-19

How to Manage Clot Formation with Covid-19

Conclusion

Clot formation in sick Covid-19 patients is responsible for many deaths in Covid-19 patients. The SARS-CoV-2 (or Covid-19 coronavirus) causes a cytokine storm with injury to the lining of the arteries. This can affect multiple vital organs and the condition may lead to organ failure. This activates the clotting system and causes clots all over the body. When this process occurs, patients get very sick and the death rate climbs. Physicians were able to rescue some patients with heparin therapy. Two international clinical trials are on the way. Hopefully  these trials answer questions about this newer treatment method. The downside of heparin therapy is the complication of massive bleeding, which causes deaths as well. When it comes to Covid-19, don’t rely on curative medicine. Strengthen your immune system by preventative therapy like vitamin D3 that can interrupt the cytokine storm.

And even with a “well-prepared” immune system it is extremely important to follow all the guidelines of distancing, disinfecting and wearing face masks. We need all the help we can get!