Dec
28
2019

Fight The Cold Or Flu With Mega Vitamin D3 Doses

Recently I came down with a cold, when I remembered that you can fight the cold or flu with mega vitamin D3 doses. The cold did not fit into my plans. I was three days before singing as a lead singer in a local church and I needed my voice. I felt a burning in the back of my throat and knew I was coming down with a cold. Next I felt congested in my nose and sinuses. I braced myself for the cold affecting my voice box and taking my voice away. But on the second day of the cold/flu I took 50,000 IU of vitamin D3. The following day the congestion was still confined to my nose and sinuses only. But it did not go any further down into my throat or chest.

Mega vitamin D3 doses saved my voice 

The following day was the church performance and everything went well. The Christmas songs created a festive atmosphere in the congregation. The psalm melody that my wife had composed was a welcome change from the normally stuffy psalm. And despite the feeling of an oncoming cold, my voice was still clear.

My cold did not progress

Since then I noticed some more mucous formation and I continued my dose of 50,000 vitamin D3 for a total of 3 doses. Through blood tests for vitamin D 3 levels I know that I am a slow absorber of vitamin D3 and normally need 10,000 IU daily to get into the normal range of 25-hydroxy vitamin D using a blood test. Now the cold symptoms settled down. There was nothing of the common laryngitis, where you sound scratchy. I also did not get a cough, which based on past experience, would have lingered on for weeks.

How vitamin D stimulates the immune system

Taking high doses of vitamin D3 releases cathelicidin and defensins.

These are polypeptides that have antibacterial and antiviral properties. The vitamin D antimicrobial pathway is described in detail here:

Vitamin D stimulates the immune system (B cells and T cells), which can suppress viral and bacterial infections. Here is another article that recommends the “vitamin D hammer” as the authors term the mega vitamin D3 therapy. Dr. Thornburg describes that an adult should treat a cold/flu within 24 to 36 hours after onset with 50,000 IU of vitamin D3 once daily for 3 days. He also lists pediatric doses. Following this treatment the patient resumes the previous vitamin D3 maintenance dose.

Opinion of conventional medicine

This approach is not conventional medicine. Here is a publication that states that Vitamin D, Vitamin C, Zinc, and Echinacea in combination can be useful in the treatment of the common cold.

But the section that describes the use of vitamin D seems to be very conservative. It does not even mention the importance of measuring the vitamin D blood levels. It is 25-hydroxy vitamin D which is what one needs to determine blood levels.

The normal level is considered to be 25-80 ng/mL. Many physicians say a level of 50-80 ng/mL is better. This blood test will measure the sum of vitamin D from oral vitamin D3 and from sun-induced vitamin D. This test also shows whether a person is a fast absorber or a slow absorber. What counts is that a person taking vitamin D3 gets the blood level into the therapeutic range.

Are there toxic levels of vitamin D?

Whenever the topic of mega dose vitamin D3 is mentioned, conventional medicine will warn that vitamin D toxicity could develop including kidney stones and “bone pain, drowsiness, continuous headaches, irregular heartbeat, loss of appetite, muscle and joint pain”.

In these cases of toxicity the researchers did not indicate what the level of 25-hydroxy vitamin D level was.

Other publications have established that the original recommended dose of vitamin D3 by the Food and Nutrition Board of 2000 IU per day was way too low. According to this publication based on many other papers 10,000 IU per day or more should be considered the new recommendation.

Dr. Schwalfenberg stated: “This is a 1-time 50, 000 IU dose of vitamin D3 or 10, 000 IU 3 times daily for 2 to 3 days. The results are dramatic, with complete resolution of symptoms in 48 to 72 hours. One-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.”

The half-life of 25-hydroxy-vitamin D3 is 15.1 days. This means that the transient elevation of 25-hydroxy-vitamin D3 will last only 5 half-lives or 75.5 days. After that time (2 1/2 months) the mega dose taken over 3 days is eliminated.

Fight The Cold Or Flu With Mega Vitamin D3 Doses

Fight The Cold Or Flu With Mega Vitamin D3 Doses

Conclusion

Vitamin D3 has long recognition as a stimulant of the immune system. We now know that high doses of vitamin D3 release two polypeptides, cathelicidin and defensins. They have antibacterial and antiviral actions. Several physicians have developed a mega vitamin D3 approach when a cold or flu just starts to hit you. An adult should then take 50,000 IU of vitamin D3 daily for 3 days. In many cases it will cut the cold/flu short within 48 to 72 hours. Dr. Schwalfenberg said that “one-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.”

Possible future clinical trial could verify effectiveness of mega vitamin D3

It would be desirable that the medical establishment conduct a clinical trial about the effectiveness of mega vitamin D3 use in colds/flus. Once the results are out, it would be loss of business for the pharmaceutical manufacturers.  Most of the cold-remedies would no longer be in high demand. For this reason it does not appear that it would be in the interest of Big Pharma or of organized medicine to organize such a clinical trial!

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Dec
07
2019

The Use Of Oncolytic Viruses For Cancer Treatment

In the first place, preliminary experiments indicate that the use of oncolytic viruses for cancer treatment may become a reality. There are several lines of research that point to the fact that oncolytic viruses can make a difference in treating incurable cancer patients.

Notably, Canadian researchers had reported in 2011 that oncolytic viruses created by genetically modifying smallpox vaccine viruses would enter tumor cells of patients, but not damage normal cells. Specifically, a high percentage of the end stage patients responded with tumor regression.

Shortly after Mayo Clinic physicians were desperate when two patients with end stage multiple myeloma, a vicious bone tumor, did not respond to chemotherapy. Significantly, they tried something unconventional: high doses of the measles vaccine in an attempt to stimulate the immune system. Here is an overview from 2014 that shows that many different cancers respond to various immunological approaches.

Study from Holland regarding end stage melanoma patients

Here is a small human study involving end-stage melanoma patients treated with the oncolytic virus T-VEC combined with pembrolizumab (Keytruda). It is important to realize that Keytruda helps to reactivate a T-cell response to the cancer cells. In this case the cancer cells absorb the oncolytic virus (T-VEC), but it leaves normal cells alone. Inside the cancer cells the oncolytic virus multiplies and destroys the cancer cells. In this 2017 study 21 patients with terminal, nonresectable melanoma received treatment with T-VEC and Keytruda. Specifically, 62% of the patients showed an objective response to the treatment. Moreover, 33% fulfilled the criteria of an immune-related response. In the past terminal patients like these had a 0% response to radiotherapy or chemotherapy.

History of research about oncolytic viruses

To begin with, in 1912 rabies virus treatment against cervical carcinoma was a first attempt to treat cancer. Researchers conducted many experiments between 1950 and 1970 with wild type or naturally attenuated viruses. This included, for example, hepatitis A and B viruses. In 1991 cancer researchers developed the concept of genetically engineered oncolytic viruses. Today cancer researchers know that the protection mechanisms in most cancer cells have deficiencies. This involves the interferon‐beta signal pathway. Having said this, there is an opportunity to let oncolytic viruses destroy cancer cells, while normal cells stay unaffected. An oncolytic virus that cancer experts use in human cancers is the genetically engineered herpes simplex virus type I (HSV‐1). Others that cancer researchers developed have strange names like T‐Vec, G47∆, JX594, CG0070 and Reolysin.

Various cancers that researchers treated with oncolytic viruses

Here are a few examples of cancers where researchers used oncolytic viruses to exert a significant therapeutic effect.

Glioblastoma

Glioblastoma is a deadly form of a brain tumor, which has a high rate of mortality. Researchers have investigated new avenues to treat this cancer. Researchers tested the genetically engineered dendritic vaccine. Initial clinical trials showed significant effectiveness compared to non-treated controls. In a large phase 3 clinical trial 331 patients with newly diagnosed glioblastoma received treatment at the time of neurosurgery with dendritic cell vaccine. 30.2% of the patients were still alive and doing well after 3 1/3 years. Without the added vaccination procedure all of these patients would have died in the past because of the aggressiveness of the glioblastoma.

Multiple myeloma

Researchers could cure multiple myeloma and other cancers by using the measles vaccine. Here is a report by the popular press about two women who had multiple myeloma. One woman got cured by high doses of a measles vaccine. The other women experienced some relief, but did not survive.

This publication explains that oncolytic viral therapy of cancer is a lot more complicated than originally thought.

Prostate cancer

Researchers found that vaccines against prostate cancer were effective with the combination of oncolytic virus therapy with regular anti-cancer treatments. But oncolytic virus therapy alone has a poorer prognosis than a combination of chemotherapy or radiotherapy with oncolytic virus therapy.

Cervical cancer

The high-risk HPV16 strain most often causes cervical cancer. The HPV (human papilloma virus) vaccine targets patients with previous exposure to HPV16. However, researchers have noticed that in some cases a phenomenon called the “HPV immune escape” has allowed in some vaccinated women to still develop cervical cancer. Now a group of researchers are investigating how the vaccine could be improved by finding out how the immune system is being tricked in these cases by the HPV virus to bypass the antibodies of the vaccine.

Pancreatic cancer

This cancer is very difficult to detect in the early stages, and as a result the outlook for chemotherapy or radiotherapy is extremely poor. Researchers have used several approaches as an alternative to conventional therapy. Immunotherapy is an option. Mayo clinic researchers have already announced that the measles vaccine approach will likely be applicable to pancreatic cancer treatment as well in the near future. However, other clinical trials are on the way to use alternative vaccination procedures.

Neuroblastoma, glioma and melanoma

This link shows that the FDA has accepted engineered oncolytic herpes virus (engineered to secrete GM-CSF) as a treatment against melanoma. Other approaches with engineered bacteria can affect neuroblastoma and glioma.

Survival data using oncolytic viruses for cancer treatment

Cancer researchers have completed a number of smaller clinical trials at this point. One of them describes end stage melanoma (stage III and IV) where the only treatment was with the oncolytic virus T‐Vec. The overall response rate compared to the control, which was only 5.7%, the experimental group with T-Vec was 26.4%. This is considered a good response rate given that we are dealing with end stage melanoma patients.

Mechanism of how oncolytic viruses stimulate the immune system to overcome various cancers

As mentioned above oncolytic viruses multiply in the cancer, once they have been incorporated. This leads to cancer cell death. It exposes the dead cancer tissue to the immune system. What helps in the process is that inhibitory proteins from the cancer cells that used to inhibit the immune system are no longer provided by the dead cancer cells. The end result is that the immune system mounts a formidable response against the cancer cells through killer T cells. This immune response also affects remote metastases of the same histological cancer type. This review article summarizes how oncolytic viruses work for cancer cell destruction and how this method can be combined with other treatment modalities.

The Use Of Oncolytic Viruses For Cancer Treatment

The Use Of Oncolytic Viruses For Cancer Treatment

Conclusion

Currently various cancer centers are involved with clinical trials in humans to test the power of oncolytic viruses. What cancer researchers have learnt is that oncolytic viruses are a useful tool to kill cancer cells. But the immune system of cancer patients is in a suppressed state. Pembrolizumab (Keytruda) is a medication that will stimulate the immune system by stimulating killer T cells to destroy cancer cells. The combined effect of killing cancer cells with oncolytic viruses and stimulating the immune system is the big news. This has been the breakthrough that cancer researchers have been waiting for. Now several clinical trials are on the way where survival rates for cancer patients given the new combination therapy are assessed.

Oncolytic virus therapy here to stay

It is a treatment which is no longer a thought model with animal experiments. Well known medical centers are using it in patients, and as the results become more obvious, it will very likely become a new treatment modality for cancer.

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Mar
23
2019

Immune System Can Trigger chronic fatigue syndrome

A study from February 2019 stated that the immune system can trigger chronic fatigue syndrome. Specifically, researchers observed that interferon treatment in hepatitis C patients could lead to chronic fatigue syndrome in 33% of patients.

Interferon treated hepatitis C patients can develop chronic fatigue syndrome

In this cased 54 patients with hepatitis C received treatment with Interferon. 18 of them (33%) developed chronic fatigue syndrome, which persisted. 57 control did not develop it. With this in mind, patients were examined at baseline, during the 6 months to 1-year Interferon treatment and 6 months following the end of the treatment.

It was noted that baseline interleukin levels (IL-6 and IL-10) were higher in the fatigued patients. Interferon treatment worsened the interleukin levels, and the interleukin levels stayed high from then on. Moreover, symptoms of pain from chronic fatigue syndrome also stayed with the patients after the treatment had ended.

Patients with chronic fatigue syndrome have a viral illness in the beginning

The lead researcher, Carmine Pariante, professor of biological psychiatry at King’s College London, noted the following. Before patients come down with chronic fatigue syndrome they frequently have a major infection or a flu virus. This certainly mobilizes an interferon response from their immune system. Professor Pariante said that it is the overstimulation of the immune system that leads to an overproduction of interferon, which likely causes chronic fatigue syndrome.

In the US an estimated 836,000 to 2.5 million Americans present with chronic fatigue syndrome according to the CDC.

The observation described above confirms the theory that a chronic stimulation of the immune system likely underlies the development of chronic fatigue syndrome. It was the patients undergoing treatment for hepatitis C with interferon, persistently high IL-6 and IL-10 levels together with pain symptoms that caused chronic fatigue syndrome.

Example of a patient with chronic fatigue syndrome

A 19-year old patient with chronic fatigue syndrome (CFS) explained that her CFS kept her hostage inside. When she gets dressed it feels like there is a blackness going over her eyes. She cannot lead a conversation or speak as she has absolutely no energy. So, the only thing she can do is to lie down and exist. Her pain and fatigue is  debilitating. She feels that her body and brain are unable to recover from even the smallest effort. About 25% of CFS cases are severe cases. This means that they are house bound, bedridden and wheelchair dependent.

Immune System Can Trigger chronic fatigue syndrome

Immune System Can Trigger chronic fatigue syndrome

Conclusion

The cause of chronic fatigue syndrome (CFS) has been a mystery for a long time. But a new UK research study has shed some light on a hyperactive immune system that may cause CFS. The research team found that 33% of patients with hepatitis C who received treatment with interferon developed CFS. When lab tests analyzed their blood values, they had developed high interleukin levels (IL-6 and IL-10). This was a sign for an overstimulation of the immune system. Other patients who did not develop CFS normalized their interleukin levels. The control patients had no changes in interleukins.

Overactive immune system can trigger chronic fatigue syndrome

The researchers are of the opinion that an overactive immune system is responsible for the development of CFS. Chronic fatigue syndrome is a devastating multi-system chronic disease with pain and weakness. A significant number of patients suffer from permanent disability. The researchers hope that with more research they may be able to find a solution and treatment protocol. Presently no form of treatment is available.

Sep
29
2018

No Amount Of Alcohol Is Good

New research, more extensive than previous research has shown that no amount of alcohol is good.

This is completely against the widespread belief that moderate consumption of alcohol would prevent heart disease.

Specifically, previous research had shown the following: one glass of alcohol per day for women and 2 glasses of alcohol for men was reportedly make us live longer.

New research with larger population numbers

But a new study involving much larger population groups, all ages, and drinkers versus non-drinkers came to a different conclusion. It concluded that the previous recommendation was based on only heart attack rates, but excluded other causes of sudden death like heart failure, a rupture of the aorta (aneurysm), high blood pressure that kills (fatal hypertensive disease) and strokes. With the compilation of all these cardiovascular diseases, the statistics suddenly started to look different. Now even small amounts of alcohol killed. What is worse, there was clear evidence that binge drinkers have much worse survival statistics than moderate drinkers. When you drink according to the American Heart Association’s recommendation, you drink smaller amounts of alcohol daily.

Binge drinking

But many of us like to live it up on weekends or whenever there are friends over who also like a few drinks. This binge drinking habit lowers the life expectancy by an average of 10 years. It does so because the list of complications I mentioned above. In addition there are alcoholic liver cirrhosis, pancreatitis and various cancers that shorten your life.

Global health study

The funders of this global health study was the Bill and Melinda Gates Foundation, and it looked at the burden that alcohol puts on 195 countries. The original study appeared in the Lancet. The combined study population was 28 million individuals. There were 649,000 cases of various deaths due to alcohol. Here is a summary of the abbreviated outcome of the global health study. As you can see from this, there is no safe level of alcohol consumption as even small amounts of alcohol over a long period of time lead to significant damage in the body. You can prevent heart attacks to a certain extent. But instead people die from a ruptured aorta, from strokes or from heart failure. The leading cause of death for men and women age 15 to 49 worldwide was alcohol. It accounted for almost 1 in 10 deaths.

Some alcohol-related statistics

The following were the observaions in the study.

  • Over 300 disabilities and diseases were directly related to alcohol consumption. The findings were collected in 195 countries, classified by age and sex. The data was gathered between 1990 and 2016.
  • Globally, 2.4 billion people drink alcohol. 25% are women who consume 0.73 drinks on average each day, 39% are men drinking 1.7 drinks a day.
  • Denmark, Norway and Germany drank the most alcohol globally.
  • For ages 50 and up the leading causes of death were: road injuries, suicides and tuberculosis.

More statistics

  • Most deaths caused by alcohol came from cardiovascular disease and cancer for all countries.
  • When you look only at drinkers, the standard recommendation of the American Heart Association regarding low alcohol consumption seems true. But the new study compared non-drinkers with drinkers. From this it is clear that even one drink a day has a risk of premature death.
  • At the age of 40 cutting down long-term alcohol use will add 1 to 2 years of life expectancy.
  • For all ages 2.8 million people die globally every year from alcohol related diseases.
  • Half of the world does not drink at all. This means that the ones, who drink, consume double as much as the statistics show.
  • Americans prefer beer. They drink about 27 gallons of beer, 2.6 gallons of wine and 2.2 gallons of spirits per adult/year.

Common clinical conditions from alcohol consumption

Binge drinking is the consumption of 5 drinks or more in an evening for men or 4 drinks for women. The CDC is concerned about binge drinking, because of its association with significant organ damages. There are 4 major concerns regarding these effects. Heart disease and cancer; diabetes; memory loss and appearance. In the following I will zero in on these alcohol-related conditions. 

Heart disease

As this article pointed out above, there is a very limited protective effect, but mostly in above 55-year-old women who drink in moderation (1 glass of alcohol; per day). They have some protection from developing heart attacks, because their LDL cholesterol gets lowered and their clotting system is influenced in positive ways. But 6% of breast cancer in women is due to the effect of alcohol consumption, which is a downfall. For both men and women binge drinking is what kills. Binge drinkers who drink more than 100 grams of alcohol per week (more than 7 drinks in the US) experience increased deaths. The causes are heart failure, strokes, fatal hypertensive disease and fatal aortic aneurysm, where the main artery bursts. Apart from that alcohol-related pancreatitis and liver cirrhosis can kill as well.

Cancer

A relatively new finding is that alcohol has a close relationship to causing various cancers. Alcohol weakens the immune system. Also, alcohol has a negative influence on the bacterial composition, the microbiome in our digestive tract, is. This can be a cause for colon cancer. Liver cancer, mouth cancer and breast cancer also has a direct relationship to increased alcohol consumption. Esophageal cancer and laryngeal cancer are also related to alcohol consumption.

Diabetes

Alcohol can stimulate the pancreas to release insulin, which may give you hypoglycemic attacks. As alcohol contains empty calories, over the course of several years alcohol consumption can add to your weight, causing obesity and type 2 diabetes. As diabetes has detrimental effects on the heart and blood vessels, this mixed with alcohol consumption, can worsen cardiovascular disease thus increasing the risk for heart attacks and strokes.

Memory loss

In the beginning of chronic alcohol consumption you may enjoy the relaxing effect of alcohol. This is merely the toxic effect of alcohol on brain cells. Alcohol has the effect of inhibiting brain cells, which makes you feel relaxed, super-sociable and even silly. In reality you are starting to loose control. After several years of this effect you are left with feelings of anxiety, depression and anger. This is when trouble starts to occur. People out of control are more likely to get into fights and get injured or killed. People can develop blackouts where they do not remember parts of the evening or an entire event. Memory loss is starting. The hippocampus is an important part of the brain that is involved in processing short- term memory into long-term memory. A form of dementia can occur that was brought on by chronic alcohol overconsumption.

Appearance

Alcohol dries out the skin cells and body cells. The face gets wrinkles. Your skin looks parched and gives you the appearance of a prematurely aged person. Alcohol can interfere with your sleep and when you have a lack of it you end up with dark circles around your eyes as well as puffy eyes. It does not make for a good picture, whether it happens inside the body or on your skin!

No Amount Of Alcohol Is Good

No Amount Of Alcohol Is Good

Conclusion

A new study that was larger and more comprehensive than any previous study has exposed the myth that one drink for women and two drinks for men would protect you from heart disease. It may protect you from heart attacks, but it definitely does nothing to protect you from other heart conditions. There is also sudden death from heart failure, a rupture of the aorta (aneurysm), high blood pressure that kills (fatal hypertensive disease) and stroke. When you factor all that in as well, even your low, moderate alcohol consumption has health risks. The global health study, funded by the Bill and Melinda Gates Foundation looked at the burden that alcohol puts on 195 countries. The combined study population was 28 million individuals.

Alcohol related deaths and diseases

649, 000 registered cases of various deaths occurred due to alcohol. This included deaths from traffic accidents, injuries, cancer, heart disease and suicide. This global study compared the life expectancy and disease frequencies of alcohol-consuming people with non-alcohol consuming people. It concluded that non-alcohol consuming people live on an average up to 10 years longer than their alcohol-consuming counterparts. No studies up to now have been that comprehensive. The results from twenty-eight million people speak for themselves, and the death statistics are clear. It is worthwhile to look at the details and draw your own conclusion.

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Jul
27
2018

Modified Poliovirus Effective Against Brain Cancer

A clinical trial found modified poliovirus effective against brain cancer. 61 patients with glioblastoma, the most deadly brain cancer there is, have been enrolled in this trial since 2012.

Glioblastoma treatment with genetically modified poliovirus

Dr. Gromeier, one of the lead cancer researchers at Duke University, Durham, North Carolina has done animal experiments. Unlike poliovirus, he found that genetically modified poliovirus was harmless for the central nervous system and yet he found modified poliovirus effective against brain cancer. This genetically modified poliovirus was attacking glioblastoma cells in cell cultures and in human brains. Dr. Annick Desjardins, a co-author of the study explained that the researchers had to take a piece of RNA away from the poliovirus and replace it with a neutral piece of RNA. This way it is still attracted to the numerous poliovirus receptors, which are expressed on many human cancers. The genetic sequence that allows poliovirus to reproduce in normal cells was taken out with the genetic modification. An inert RNA piece from the rhinovirus, the cause of the common cold was replacing this.

Effect of the genetically modified poliovirus

This way the modified poliovirus is no longer destroying nervous tissue. But the virus can still multiply in the glioblastoma cells, release toxins and kill these cancer cells.

Dr. Bryan Choi is a fellow in the Cellular Immunotherapy Program at Massachusetts General Hospital Cancer Center. He also works at the Department of Neurosurgery at Harvard Medical School. Although he was not part of this study he stated that this study was a giant step forward. “Perhaps the most promising aspect is the ability for this genetically modified virus to not only directly kill brain cancer cells, but to release tumor antigens,” Choi said. Antigens are toxic substances that stimulate the immune system to mount an immune response against the cancer. This immunotherapeutic effect is an important aspect of this new treatment modality.

Some human statistics of the pilot study showing modified poliovirus effective against brain cancer

Here are the highlights.

  1. 21% of the poliovirus patients are still alive three years after treatment; this compares to just 4% of the control patients who only received chemotherapy.
  2. The average survival time for the 61 patients who have received the genetically modified poliovirus therapy was 12.5 months. This compares with 11.3 months for a control group of matched patients. These had received standard treatment (chemotherapy).
  3. Some patients were much better responders than others. A 20-year old man a 60-year-old man survived 69 months (nearly 6 years). They are still alive today. This was unthinkable of in the past for patients with glioblastoma.

Repeat modified poliovirus therapy for glioblastoma recurrence

Dr. Darell D. Bigner, a co-author of the study, a professor of pathology and emeritus director observed the following. Some patients experienced initial reduction of the glioblastoma, and when the cancer came back they received repeat modified poliovirus treatments. To the surprise of the investigators the tumors shrank again and again. This was never the case with conventional chemotherapy. Once a glioblastoma is chemotherapy-resistant, chemotherapy will not work again.

Experience with modified poliovirus therapy

  1. In this trial treatment for glioblastoma started with implanting a catheter right into the center of the glioblastoma. An infusion of the engineered poliovirus followed, a process that could take up to 6.5 hours. Removal of the catheter was next.
  2. In the beginning researchers used higher doses of the genetically engineered poliovirus. Some people developed severe inflammation causing seizures, which needed treatment. Confusion and language difficulties were also side effects. Others developed pronounced nausea. The researchers decided to lower the dosage of the genetically engineered poliovirus, and the patients still had good clinical results.
  3. “We are presently enrolling in a phase 2 trial combining the genetically modified poliovirus with one dose of chemotherapy,” Desjardins said. “We are also enrolling in a trial for pediatric brain tumor patients.” In addition studies using genetically engineered poliovirus against breast cancer and against skin cancer are also in the planning stage.
  4. There are other new approaches where there the doctor injects the photosensitizer indocyanine into breast cancer tissue. Next the doctor points a laser beam near the infrared frequency of light to the cancer area. You find details about this procedure here.
Modified Poliovirus Effective Against Brain Cancer

Modified Poliovirus Effective Against Brain Cancer

Conclusion

A new approach to treating glioblastoma, one of the deadliest brain cancers, has shown promising results. A genetically engineered poliovirus is no longer making the person sick with polio, but instead destroys glioblastoma cells and prolongs patients’ lives. Some patients lived up to 6 years while controls lived less than one year. The effect of this new treatment occurs from the release of toxins within the glioblastoma cancer. This leads to cancer cell death and the release of these toxins. The immune system receives stimulation to recognize and destroy the remaining glioblastoma cells. At this point the basic steps of this new therapy are in place.

Future direction of research

But the same method will one day likely be in use for other cancers. There are plans for new clinical trials to examine this further. The researchers also want to test cure rates of a combination of chemotherapy and genetically engineered poliovirus therapy. This will answer the question whether the combination treatment will be better than genetically engineered poliovirus therapy alone.

Jul
21
2018

Frequent Flying Can Increase Cancer Rates

A review article from June 25, 2018 discusses that frequent flying can increase cancer rates. A study showed that cancer of the breast, cervix, skin, thyroid and uterus are about twice as common in female stewardesses than in women at large. Also, gastrointestinal system cancers including cancer of the colon, stomach, esophagus, liver and pancreatic cancers are more common. This observation was true in both male and female flying personnel who engage in frequent flying. This publication comes from a scientific paper published on June 26, 2018.

Study of flight attendants

Patients from the National Health and Nutrition Examination Survey (NHANES) served as a control for flight attendants. This control group consisted of 2729 patients; they were of a similar socioeconomic status as the flight attendants. In contrast there were 5366 flight attendants with much higher cancer rates than normally expected. Specifically breast cancer had a 1.51-fold higher frequency than the control group. Melanoma had a frequency of 2.27-fold in comparison to controls, and non-melanoma cancers had a cancer rate of 4.09-fold when compared to controls. Non-melanoma cancer cases include basal cell and squamous cell carcinomas.

Cancer rates in pilots

In a meta-analysis of various studies it became obvious that pilots had 20% more prostate cancer than a non-pilot control group. However their mortality was not higher than controls.

In an interesting study spanning over 60 years Icelandic airline pilots underwent an analysis for cancer development.

83 cancers were registered. The general population (non-pilots) served as controls.  There was an increase of 2.42-fold for all cancers compared to controls. Prostate cancer was higher in these pilots by 2.57-fold. Malignant melanoma had a 9.88-fold increase in pilots in comparison to controls. The basal cell carcinomas in these pilots were 3.61-fold more common than the rates in the controls. With regard to basal cell carcinomas of the trunk there were 6.65-fold more of them in comparison to controls.

The difference between the pilots and the general population was likely due to the higher exposure to cosmic radiation. This is what the authors concluded.

How does cancer develop?

There are several ways cancer can develop. One of the known cancer causations is ionizing radiation. We know a lot about this from the atom bombs of WWII in Japan. There were many more thyroid cancers in children than were normal following the dropping of the atom bombs.

But diagnostic CT scans and X-rays are not without risk of cancer development either. There is a lag period of 10 to 20 years and even longer. But after this time the higher cancer rate becomes measurable. A person who had a CT scan done as a diagnostic test in childhood will still have a 25% higher cancer rate 15 years later. This is how powerful radiation of the DNA of our cells is despite inherent repair mechanisms that fight back to keep things normal.

Single cancers versus multiple cancers

It is interesting that female stewardesses and male pilots came down with a mix of various cancers. There were skin cancers, breast cancers, cancers of the prostate and many gastrointestinal cancers. The numbers were not big enough to show statistical significance for leukemia also being a likely cause of cancer from cosmic radiation.

If cosmic radiation was going through the body randomly hitting various DNA strands in all cell types, which could explain why a random number of cancers develop in those cells that got the highest exposure. The ones who got above average cancer were stewardesses and pilots who were longest on their jobs. A variety of cancers would develop from various tissues. This is exactly what the studies have shown.

There are frequent flyers like business travelers and vacation seeking retirees who will also be at a higher risk of developing cancer. The more they fly, the higher the risk.

Other causes of cancer

Cosmic radiation is only one cause of cancer. There are many other causes of cancer. If you smoke heavily or abuse alcohol this can cause genetic mutations of cells that can develop into cancer. There is a pathway to cancer, which consists of initiation, promotion and progression. After those initial hurdles the cancer cell will multiply and start metastasizing into other areas of the body.

Carcinogens can damage the DNA of cells. In the case of pollution carcinogens enter the body through the air. But consuming processed meat and red meat has a proven link to cancer development as well, namely colon cancer.

Diverse factors all can cause cancer

Chronic inflammation from chronic infections is also carcinogenic. Chronic gastritis is caused by H. pylori. After years of infection with this pathogen stomach cancer can develop. Hepatitis viruses that are chronically present in liver cells can be the cause of liver cancer. Human papilloma virus (HPV) is the cause for the development of cancer of the cervix. The majority of cancer is caused from the environment or by poor life styles. Only 5 to 10% of cancers are inherited.

Tumor suppressor genes are important in terms of resisting the development of cancer. The TP53 gene produces a protein that interferes with the multiplication of cancer cells. Cancer cells in turn can produce a protein that interferes with TP53 function. The end result is that it will interfere with the body’s immune system to produce killer T cells. This way the cancer has the upper hand. There are some herbs that have shown anti-cancer effects, such as curcumin. https://www.askdrray.com/curcumin-and-cancer/. As I explain in this blog, there are absorption problems with curcumin presently. It is not yet primetime for curcumin, but it could be once the absorption problems are overcome. Nevertheless the research surrounding curcumin is interesting.

Frequent Flying Can Increase Cancer Rates

Frequent Flying Can Increase Cancer Rates

Conclusion

Several interesting studies have shown that stewardesses, pilots and frequent airplane travellers have a higher risk of developing cancer. Research groups have been careful to control these studies for lifestyle factors and other causes of cancer. Exposure to cosmic radiation is the common culprit that is behind this cancer causation. There was a multitude of cancers rather than one single type of cancer in pilots and stewardesses. This makes it more plausible that it is indeed cosmic radiation that caused the cancer increase. But cancer development is complex, and I have summarized this briefly here. It is important to be aware of all the possible causes of cancer. This allows you to minimize your exposure to carcinogens. We all get exposure to carcinogens from pollution. In addition we get exposure to cosmic radiation according to how much time we spend flying to holiday destinations or on business trips. Be safe and be informed!

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Jan
13
2018

Immune Support For Cancer Patients

Immune support for cancer patients is necessary when their platelets are decreasing from chemotherapy. Dr. John L. Hall gave a talk at the 25th Annual World Congress on Anti-Aging Medicine in Las Vegas, Dec. 14-16, 2017. He pointed out that when cancer patients receive chemotherapy their platelet counts in the blood decline. Dr. Hall participated in a 2010 study that investigated the use of RNA fragments to protect stem cells in the bone marrow from chemotherapy. The study showed how  fragments coming from E.coli protected patients’ bone marrow cells. This immune support for cancer patients allowed physicians to carry on with regular dosing of chemotherapy treatments for the patients’ cancer. There was no dosage reduction necessary and no interruption of the treatment schedule. The optimal dose was 80mg sublingually of RNA derived from E. coli, and patients self-administered the dosage every other day.

Low platelets mean bleeding

Normally patients would bleed or bruise easily when they received chemotherapy without protection by RNA fragments. There would be frequent nosebleeds, bleeding in the gums or in the mouth. Patients would also have blood in urine and get petechia on their skin.

Consequences of low platelet count on cancer patients

There are several consequences for cancer patients, when their platelets are low with chemotherapy.

  • Patients with low platelets have fatigue
  • They experience limitations with regard to physical function
  • When platelets are low, patients need platelet perfusions
  • There is compromise of their cancer treatment because chemotherapy needs adjustment of  or the dosage, or the therapist needs to postpone further treatment.
  • Their survival rates are lower due to cancellation of chemotherapy treatments
  • More medical resources are necessary because of platelet transfusions

How do RNA fragments work?

RNA fragments act as primers triggering DNA synthesis in bone marrow stem cells. Fragmented RNA is also protective of bone marrow cells when the patient receives chemotherapy. In animal experiments, where toxic chemotherapy was given, fragmented RNA allowed these animals to survive. This prompted oncologists to introduce this treatment modality into end stage cancer patients who are receiving chemotherapy. Results were stunning. The patients from age 18 to 80 tolerated the RNA fragments well. They were able under the influence of the RNA fragments to continue with their regular chemotherapy to completion of the therapeutic course. When laboratory tests measured platelets, the results were normal. The investigators concluded that the RNA fragments protected the bone marrow stem cells of platelets.

The tumors in this trial involved pancreatic cancer, head and neck cancer and cancer of the breast. In addition physicians also treated colon cancer, esophageal cancer and lung cancer .

More details about RNA fragment therapy in cancer patients requiring chemotherapy

Cancer patients who had no protection by RNA fragments had platelet levels that became lower and lower with every chemotherapy treatment cycle. Some patients never returned to normal platelet levels even once the chemotherapy stopped. Other cancer patients’ platelets took month before they returned to normal. Patients in this group either needed to either reduce  their chemotherapy dosage or put treatments on hold. Alternatively their treatment stopped prematurely.

In contrast patients whose bone marrow received protection by RNA fragment therapy had stable platelet levels. Their platelet levels recovered quickly to normal after each cycle of chemotherapy. No unplanned chemotherapy reduction was necessary and no platelet transfusions were required. All the patients were able to complete the treatment plan.

The physicians also observed that with RNA fragment therapy the peak platelet counts were still in the normal range despite chemotherapy. When patients recovered from the chemotherapy effect the platelets stayed in the normal range.

Insulin potentiation therapy

Research has shown that cancer cells have more insulin receptors than normal cells. Physicians used this fact  with a form of chemotherapy where the patient receives small doses of insulin first. Following that the patient can receive lower doses of chemotherapy. Dr. Donato Perez Garcia MD is the inventor of the insulin potentiation therapy (IPT). With this treatment the patient can receive lower than normal chemotherapeutic agents , which reduces the toxic side effects of chemotherapy. Unfortunately the side effect of the lower dose of chemotherapy still hits the bone marrow. As a result the platelets are dangerously low. Dr. Hall mentioned that RNA fragments are also effective with insulin potentiation therapy. This keeps the platelets in the normal range and patients can complete the course of insulin potentiation therapy.

More background about the insulin potentiation therapy

Dr. Robert Baratz has reviewed the merits of IPT thoroughly. He came to the conclusion that the so-called research about the effectiveness regarding IPT has not been done properly. In his opinion it is not proven that less chemotherapy is required when pretreatment with insulin has been done. There are also dangers that connect with insulin therapy. If the insulin dosage is too high blood sugar will go into dangerously low levels. The FDA has never accepted that the IPT procedure would be superior to standard chemotherapy. However, regardless of the chemotherapy dosage these chemicals are bone marrow toxic. Particularly the toxic effect on stem cells of platelets will cause diminished platelet counts in the blood with both procedures. In both cases RNA fragment therapy will overcome the toxic effect on the bone marrow stem cells.

Immune Support For Cancer Patients

Immune Support For Cancer Patients

Conclusion

Bone marrow suppression by chemotherapy has been a limiting factor for many years prior to the detection of RNA fragment therapy (RFT). RNA for RFT is derived from E. coli cultures. RNA fragments act as primers triggering DNA synthesis in bone marrow stem cells. This leads to the production of platelets that protect the patients from the toxic effects of chemotherapy on bone marrow. RFT allows the patient to receive treatment with chemotherapy without having to worry about bone marrow toxicity. No chemotherapy dose reduction is necessary and no platelet transfusions are needed. RFT should be a regular accompaniment to chemotherapy treatments for any cancer patient.

Dec
30
2017

Fasting Mimicking Diet

The fasting mimicking diet (FMD) was at the center of this year’s anti-aging conference in Las Vegas. This was the 25th Annual World Congress on Anti-Aging Medicine in Las Vegas, Dec. 14-16, 2017. Dr. Valter Longo, PhD reviewed some of the research he had done on longevity in yeast cells, worms and mice.

Fasting mimicking diet relevant in humans

Dr. Longo pointed out that this type of research has relevance in humans. If there was a cure for cancer, heart disease, stroke and diabetes, we would live 13 years longer. But if we stimulated longevity with this pulsed calorie restricted diet, we would live on average 30 years longer. There is a rare genetic abnormality where people are deficient for IGF-1, a growth factor produced in the liver. These genetically IGF-1 deficient people live longer and do not develop cancer. Observations like these and detailed mouse experiments inspired Dr. Longo to develop a new diet plan. Patients would receive a fasting mimicking diet on 5 days per month. The rest of the month would consist of a normal, balanced diet. 5 days of the month the person would consume a low 800-calorie diet. This is enough to ensure adherence to the diet, but low enough to lead to enormous metabolic changes including youth-preserving stem cell stimulation.

Clinical Application of fasting mimicking diet in cardiovascular health

Dr. Joel Kahn, Prof. of Medicine at the Wayne State University School of Medicine lectured later that day. He is also the Director at the Kahn Center for Cardiac Longevity. His talk was entitled “The Fast Track to Slow Cardiac Aging: Fasting &Targeted Nutrition”. He mentioned that a fasting mimicking diet was a powerful tool in cardiology to prevent heart attacks and hardening of arteries. He explained in detail the complex aging pathways that involve three components, IGF-1, mTOR and PKA. When lifestyle choices stimulate these genetic markers, accelerated aging is a consequence. But with the inhibition of those markers longevity can happen. He added that researchers looked at heart cells, where the same principles apply. Dr. Kahn pointed out that the basic research of Dr. Longo enables clinicians to see positive results in patients who follow caloric restriction for 5 days in a month on a regular basis.

How does the fasting mimicking diet work?

It is best to let one of the users of this diet explain how it works. Once per month you eat calorie-restricted food with only 800 calories per day and you follow this regimen for 5 days. Some patients receive 1100 calories for the first of these 5 days, if they have difficulties switching from normal food to the boxed food. Dt. Longo has developed boxed food, called ProLon (from L-Nutra). ProLon stands for “pro longevity”. Dr. Longo and Dr. LaValle mentioned at the conference that these prepared meals make it a lot easier for patients to stick to the low calorie diet. Three hundred dollars for the boxed food for 5 days are a stiff price, and this may well be out of reach for you.

Alternative way to make your own 800 calorie food at home

Nevertheless, this should not stop you. You can look at the ingredients online and copy the boxed food by creating your own balanced 800 calories per day food at home. It is true: you have to do some research! But counting calories and finding information about the caloric content of food on the Internet is not difficult. And preparing these very, basic, small and simple meals does not require a degree in nutrition. Here is another testimony from a user of the fasting mimicking diet.

Effect of the fasting mimicking diet on the metabolism

In the past it was thought that only ketogenic diets or periods of fasting would trigger longevity genes. But the basic research of Dr. Longo and others has shown that a low calorie diet for only 5 days can achieve the same thing. Longevity genes are activated; the negative aging pathways including IGF-1, mTOR and PKA are suppressed. The immune system gets activated from this. It also  leads to lowering of LDL cholesterol, triglycerides, blood pressure, insulin resistance, and diabetes improves. With the fasting mimicking diet the stomach sees some food, but the cells are fasting. According to Dr. Kahn this combination down regulates the body’s key nutrient-sensing pathways, which activates cellular regeneration and rejuvenation.

Clinical observations

Dr. Khan observed a high compliance rate with 3 cycles of the fasting mimicking diet. 94% of a group of patients were compliant over 3 months. Mild fatigue, mild headaches and mild weakness were present, but improved with each cycle. In addition to the above findings Dr. Khan found that there was weight loss, abdominal fat loss and waist circumference loss. There was also a reduction in IGF-1 levels, a reduction of the C-reactive protein and stimulation of stem cells.

Inflammation reduced, autoimmune diseases improved

The reduction of the C-reactive protein proves that semi-fasting reduces inflammation. The finding of stimulation of stem cells explains that regenerative processes can take place. Pain disappears, people report more energy and are generally feeling better.

There are other clinical findings. The positive effects from following the fasting mimicking diet last for several months. Also, when patients are on chemotherapy for cancer, the FMD will protect the healthy cells from the side effects of chemotherapy.

Dr. Kahn and Dr. LaValle noted that autoimmune disease responded to FMD. This was shown in both animal experiments using mice and in clinical case reports. Dr. LaValle described a 46-year old former Olympic athlete swimmer who had multiple sclerosis. After FMD she lost all of her muscle aches and cured her optic neuritis. This was something conventional medicine could not do for her.

Clinical applications of fasting mimicking diet

Here are some of the conditions that will respond to it.

  • Obesity, because of the weight loss effect
  • Diabetes: insulin resistance becomes lower and blood sugar levels drop.
  • High blood pressure reduced: many patients were able to reduce their medications or discontinue them
  • Prevention of heart attacks and strokes
  • Pain conditions will improve as all kinds of pain disappears, an effect for which at this point is no explanation
  • Autoimmune diseases like MS and rheumatoid arthritis improve, likely because of the effect of increased stem cell circulation
  • Prevention of heart attacks because of reduction of LDL, triglycerides and CRP
  • Cancer cure rates improved by protecting normal cells and bone marrow
  • Longevity improved in mice with a 3-fold increase of their life span. Telomere length in humans was increased. Increased stem cells will find defective areas that need repair. This effect will open up a new chapter in medicine.

Maintaining the achievements of the fasting mimicking diet

At this point the implications of this new approach to weight loss and metabolic rejuvenation can only be estimated.

Limiting calories for 5 days triggers a metabolic change, which is permanent. You can experience the full effect of this rejuvenating low calorie treatment. You can do it every month without having to fear vitamin or mineral deficiencies.

Here is another link to the website of Dr. Axe where the fasting mimicking diet is also recommended.

Fasting Mimicking Diet

Fasting Mimicking Diet

Conclusion

The 25th Annual World Congress on Anti-Aging Medicine in Las Vegas, Dec. 14-16, 2017 had a new theme. Several talks dealt with the fasting mimicking diet (FMD). It is a calorie-reduced diet for 5 days in a month that will reset your metabolism. But it will also stimulate your stem cells and can heal autoimmune diseases. If you need chemotherapy for cancer, it protects your bone marrow and improves cancer cure rates. The interesting thing is that the effects of this low calorie treatment persist permanently for many months.

With the help of this diet longevity has been shown in mice; there has been a threefold life expectancy boost. Smaller trials in humans have shown telomere lengthening and stem cell stimulation. It is too early to say what the long-term effects will be for humans. But you can treat yourself with the FMD for 5 days of every month on an ongoing basis. The other days of the month you are eating a normal diet. This will ensure that your metabolism stays in top shape.

A healthier and longer life

Practical applications for the FMD are huge. Patients with obesity, diabetes and pain conditions all benefit from this. High blood pressure drops. There will be prevention of heart attacks, and there is improvement in patients with autoimmune diseases. There is better cancer survival when on the FMD. Finally there is a strong possibility that you will live longer, but also stay healthier on this intermittent calorie restricted diet.

As Dr. LaValle said: it is “fasting with food”, and Dr. Kahn added: “Eat less, live more!”

More info:  Life extension through calorie restriction.

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Jul
22
2017

Relaxation Reduces Inflammation

Relaxation can calm your mind, but new research has shown that relaxation reduces inflammation as well.

This article is based on a research paper in Frontiers in Immunology in June of 2017.

It concentrated on the calming effect of meditation on the nuclear factor kappa B (NF-κB), which causes inflammation. We know that overstimulation of the sympathetic nervous system activates the inflammatory pathway by expressing the genes responsible for NF-κB. These authors showed that the reverse is true also, namely that  meditation suppresses inflammation.

This metaanalysis of 18 research papers included 846 participants.

Here are brief summary findings of these 18 studies. Note that diverse relaxation methods had very similar results on the genes expressing inflammatory markers.

1. Qigong practitioners

First of all, a group of Qigong practitioners had 132 downregulated genes and 118 upregulated genes when compared to non-meditating controls. Meditation strengthens the immune system and delays cell death.

2. Sudarshan Kriya yoga

Also, one form of yoga breathing is Sudarshan Kriya yoga. Subjects who practiced this form of breathing yoga for 1 hour per day did not have the stress-related response on white blood cells. In contrast, the controls who did not meditate this way showed no change in the white blood cell response to stress. Those practicing yoga had a strengthened immune system. The meditators also showed strengthening of genes that inhibit cell death.

3. Chronic lymphocytic leukemia

Furthermore, eight patients with chronic lymphocytic leukemia were practicing the “seven yoga breathing patterns”; the popular Indian yoga teacher, Swami Ramdev, developed these. Those patients practicing the breathing yoga technique activated 4,428 genes compared to controls. They showed an up to twofold upregulation, which strengthened their immune system.

4. Loneliness in older people

Another study noted that loneliness in older people causes inflammation, morbidity and mortality. 55-85 year old volunteers were taking a course of mindfulness-based stress reduction. The researchers wanted to find out whether it was due to increased inflammation that older people were more susceptible to disease. The physicians tested blood mononuclear cells for genome-wide transcriptional profiling. Those older persons who had reported loneliness had more transcription factors for nuclear factor kappa B (NF-κB) than controls without feelings of loneliness. After an 8-week course those who no longer felt loneliness had a reversal of proinflammatory gene expression. The genes that had changed expression were located on monocytes and B-lymphocytes; these are cells of the immune system.

5. Care workers for patients with mental health problems

Care workers who looked after patients with mental health problems or chronic physical problems often have stress-induced chronic inflammation markers in their blood. A study involving 23 caregivers used a practice of Kirtan Kriya Meditation (KKM) assisted by an audio recording every day for 8 weeks. The subjects filled in questionnaires for depression and mental health before and after the 8-week trial. Physicians also took blood samples for transcriptional profiling before and after the KKM trial.

Meditation effects genes and reduces inflammation

The KKM meditation group had significantly less depressive symptoms and showed improvements in mental health. There were down-regulations in 49 genes and up-regulations in 19 genes compared to the controls. The pro-inflammatory NF-κB expression showed a decrease; the anti-viral gene expression showed an increase. This was measured using the IRF-1 gene. This gene controls the expression of the interferon-regulatory factor 1 (IRF-1 gene), which controls the immune response to viral infections. The interesting observation here was that a time of only 8 weeks of meditation was able to reduce inflammatory substances in the blood and could activate the immune system to fight viruses better. Further tests showed that it was meditation that stimulated the B cells and the dendritic cells.

6. Younger breast cancer patients

Younger breast cancer patients taking a mindfulness meditation course: Another study involved younger stable breast cancer patients after treatment that also had insomnia. Patients with both breast cancer and insomnia often have a lot of inflammatory markers in the blood. In a study with 80 patients 40 underwent treatment with Tai-Chi exercises, the other group of 40 with cognitive-behavioral therapy. Tai-Chi exercises reduced IL-6 marginally and TNF (tumor necrosis factor) significantly. There was a 9% reduction with regard to the expression of 19 genes that were pro-inflammatory; there was also a 3.4% increase with regard to 34 genes involved in regulating the antiviral and anti-tumor activity in the Tai-Chi group when compared to the cognitive-behavioral therapy group.

Measurable results of mindfulness meditation course

While cognitive therapy has its benefits, the winner was the Tai-Chi group where there was down-regulation of 68 genes and up-regulation of 19 genes. As in the prior study there was a decrease of the pro-inflammatory NF-κB expression, which reduced the inflammatory response.

7.  Study with fatigued breast cancer patients

In another breast cancer study with fatigued breast cancer patients the patients practiced 3 months of Iyengar yoga. After 3 months of yoga 282 genes showed up-regulation and 153 genes showed down-regulation. There was significant lowering of the expression of NF-κB. This suggests a lowering of inflammation. At the same time questionnaires showed that the fatigue factors experienced a reduction 3 months after initiating yoga exercises.

8. Mindful meditation used in younger breast cancer patients

A group of 39 breast cancer patients diagnosed before the age of 50 received six weekly 2-hour sessions of mindful awareness practices (MAP). This program is very suitable for cancer survivors. In addition to the group sessions the patients also did daily exercises of between 5 minutes and 20 minutes by themselves. The control group consisted of patients on a wait list. The investigators used several psychological measure (depression and stress) and physical measures (fatigue, hot flashes and pain) to assess their progress. Gene expression in the genome and inflammatory proteins were measured at baseline and after the intervention.

Effects of mindful awareness practices

Mindful practices showed clear benefits: they reduced stress, and sleep disturbances, hot flashes and fatigue showed improvement. Depression also shoed a marginal reduction. There were 19 pro-inflammatory genes that were mad ineffective, but not in the control group that did not do mindful practices. Gene tests revealed that transcription factor NF-κB had significant down-regulation. Conversely the anti-inflammatory glucocorticoid receptor and the interferon regulatory factors showed higher values. Genes with down-regulation came from monocytes and dendritic cells while genes with up-regulation came from B lymphocytes.

9. Telomerase gene expression

Lifestyle modification changes telomerase gene expression: 48 patients with high blood pressure enrolled in an extensive lifestyle program teaching them about losing weight, eating less sodium, exercising, adopting a healthy diet and drinking less alcohol. The other choice was to use transcendental meditation (TM) combined with health education with weekly sessions for 4 months. It turned out that both programs led to an increased expression of telomerase genes. Both groups did not show telomerase changes, but the authors stated that the observation time was too short for that to occur. The extensive health education program turned out to be better for patients with high blood pressure as it decreased the diastolic blood pressure more and resulted in healthier lifestyles.

10. Older patients with insomnia

Mind-body interventions for older patients with insomnia: Examiners divided a sample of 120 older adults with insomnia into two groups. They treated one group with cognitive-behavioral therapy (CBT), the other group with Tai Chi. The control group consisted of a group of people participating in a sleep seminar. 4 months after the intervention the CBT group had a significantly reduced C-reactive protein (CRP). The pro-inflammatory markers were lower in both groups after 2 months and in the Tai Chi group this remained low until 16 months. Gene expression profiling showed that CBT downregulated 347 genes and upregulated 191 genes; the Tai Chi group had downregulated 202 genes and upregulated 52 genes. The downregulated genes were mostly inflammatory genes while the upregulated genes controlled mostly interferon and antibody responses.

11. Patients with bowel disease

19 patients with irritable bowel syndrome (IBS) and 29 patients with inflammatory bowel disease (IBD) were treated with a relaxation response-based mind-body intervention. This consisted of 9 weekly meetings, each lasting 1.5 hours and practices a home for 15-20 minutes. The participants were taught breathing exercises and cognitive skills designed to help manage stress. At the end of the mind-body intervention and at a follow-up visit 3 weeks later participants of both the IBS and IBD groups scored higher in quality of life and lower in the level of anxiety they had before. They had reduced symptoms of their conditions.

Results of relaxation response-based mind-body intervention on IBS patients

The IBS group showed an improvement in 1059 genes. These were mostly improvements in inflammatory responses, in cell growth, regarding proliferation, and also improvements in oxidative stress-related pathways. The IBD group showed improvements in 119 genes that were related to cell cycle regulation and DNA damages. Other genetic tests showed that NF-κB was a key molecule for both IBS and IBD. The main finding was that relaxation response-based mind-body intervention was able to down regulate inflammation in both IBD and IBS.

12. Caregivers for Alzheimer’s patients receiving a course of MBSR

25 caregivers participated in a course of mindfulness based stress reduction (MBSR). Using 194 differently expressed genes the investigators could predict who would be a poor, moderate or good responder to the MBSR intervention. These genes related to inflammation, depression and stress response. 91 genes could identify with an accuracy of 94.7% at baseline whether the person would receive psychological benefits from the MBSR program.

13. Higher state of consciousness in two experienced Buddha meditators

Genetic tests showed, similar to the description of other cases that genes affecting the immune system, cell death and the stress response experienced stimulation. EEG studies in both individuals during deep meditation were almost identical with an increase of theta and alpha frequency ranges.

14. Rapid gene expression in immune cells (lymphocytes) in the blood

One study used gentle yoga postures, meditation and breathing exercises. 10 participants recruited at a yoga camp had yoga experience between 1.5 months and 5 years. Their response resulted in 3-fold more gene changes than that of controls. Otherwise the findings were very similar to the other studies.

15. Genomic changes with the relaxation response

The relaxation response (RR) is the opposite of the stress response.  One study examined how various modes of entering into the relaxation response like yoga, Qi Gong, Tai Chi, breathing exercises, progressive muscle relaxation, meditation, and repetitive prayer would lead to beneficial gene effects. As in other studies inflammation was reduced and the immune system was stimulated from the relaxation response. This was verified with detailed gene studies. The authors noted that different genes were activated in people who had done long-term RR practice versus people who practiced RR only for a shorter time. There were distinctly different gene expressions.

16.  Energy metabolism and inflammation control

Relaxation responses beneficial for energy metabolism and inflammation control: Experts with experience in RR were compared with a group of novice RR practitioners. Experts and short-term practitioners expressed their genes differently at baseline. But after relaxation both experts and novices had gene changes in the area of energy metabolism, electron transport within the mitochondria, insulin secretion and cell aging. The upregulated genes are responsible for ATP synthase and insulin production. ATP synthase is responsible for energy production in the mitochondria and down regulates NF-κB pathway genes. Inflammation was reduced by these changes. All these beneficial gene changes were more prominent in expert RR practitioners. Other beneficial changes noted were telomere maintenance and nitric oxide production in both expert and novice RR practitioners.

17. Relaxation changes stress recovery and silences two inflammatory genes

Mindfulness meditation changes stress recovery and silences two inflammatory genes: Experienced meditators were tested after an intensive 8-h mindfulness meditation retreat workshop. Two inflammatory genes were silenced by mindfulness meditation compared to controls. Other genes that are involved in gene regulation were found to be downregulated as well. These experienced meditators had a faster cortisol recovery to social stress compared to controls.

18. Vacation and meditation effect on healing from disease

This last study investigated the effect of a 6-day holiday retreat. One group was offered a 4-day meditation course, one group was the control group just holidaying and the third group was an experienced meditation group who also took the retreat meditation course. Depression, stress, vitality, and mindfulness were measured with questionnaires. All groups were positively changed after the holiday and remained this way at 1 month after the retreat. 10 months after the retreat novice meditators were less depressed than the vacation control group. At the center of the experiment was the gene expression study.

Effects of holiday and meditation

390 genes had changed in all of the groups. The authors assumed that this was due to the relaxation experience of the retreat. The genes involved related to the stress response, wound healing, and injury. Other genes measured inflammation (control of tumor necrosis factor alpha). Another set of genes measured the control of protein synthesis of amyloid beta (Aβ) metabolism, which causes Alzheimer’s disease and dementia. All groups had markers that indicated less risk of dementia, depression and mortality, which was likely due to the relaxation from the retreat.

Relaxation Reduces Inflammation

Relaxation Reduces Inflammation

Conclusion

This study is a meta-analysis of 18 research papers. The authors found that very different approaches to relax the mind have fairly consistent universal effects on reducing inflammation. Most of this work was done with genetic markers. No matter what type of relaxation method you use, you will have beneficial effects from it. But the beneficial effect is not only strengthening the immune system, it also improves sleep, depression, anxiety and blood pressure. In addition it is improving your stress response, wound healing, risk of dementia and it reduces mortality. We don’t quite understand all of the details yet.

What is definitely documented is the effect of the mind-body interaction. It also points clearly to the relaxation response from meditation and similar relaxation methods. This has been proven beyond any doubt through genetic tests.

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May
27
2017

What Your Shopping Cart Reveals

What your shopping cart reveals is what I studied on several of our trips to the US. Since my retirement in 2010 my wife and I travel quite a bit in the US and find it interesting to watch what people place into their shopping carts.

Typical shopping cart I have observed

The typical shopping cart in a US grocery store seems to consist of white bread, pizza, bacon, hamburger meat, potato chips, cookies, cornflakes, grapes, celery, peppers, strawberries and apples. In addition many people buy prepared breaded chicken strips, milk and an assortment of fruit yogurts.

I like to comment on each of these items, what I am thinking and what precautions you need to be aware of.

White bread and pizza

The problem with white bread and pizza is the wheat, which nowadays is Clearfield wheat. A chemical company from Germany was able to chemically modify the genes of wheat in the 1960’s and 1970’s; in addition they used radiation of the seeds. The farmers liked that the new wheat (called Clearfield wheat) grew with stronger roots, shorter final stems and much larger grains so the yield per acre was higher. This type of wheat was patented under the name of Clearfield wheat and sold all around the world. What was not publicized at the time was that the composition of wheat strains increased manifold compared to what was in use before for thousands of years.

Higher gliadin content of Clearfield wheat

Gliadin gets rid of the glue like substance between the gut cells and causes leaky gut syndrome, something that I heard mentioned at many lectures at several of the Anti-Aging conferences of A4M in Las Vegas. This leads to exposure of immune cells to foreign proteins from the gut, which causes the immune system to hyper react with autoimmune antibodies. As a result, many persons react to wheat with indigestion and digestive problems. They may believe that they react to gluten. It is true that Clearfield wheat also has a higher gluten contents. But any tests for celiac disease will come up empty.

We don’t want to eat this as bread, burgers or pizza: but all of them are baked with the wheat that has been chemically force-hybridized into Clearfield wheat.

Bacon and hamburger meat

A prospective study of 72,113 women over 18 years found a definitive relationship between dietary patterns and cancer and heart attacks. A prudent diet with a high intake of vegetables, fruit, legumes, fish, poultry, and whole grains had a very low cancer and heart attack rate. Conversely a Western diet consisting of high intake of red meat, processed meat, refined grains, French fries, and sweets/desserts led to a higher cardiovascular mortality risk of 22% and a higher cancer mortality risk of 16%.

There is another question you should ask: is it grain-beef or is the beef grass-fed?

Meat from grass-fed beef contains 5-times the amount of omega-3 fatty acids compared to corn- or grain-fed beef. Another issue is corn, if that is fed to beef cattle. There is obviously a deliberate marketing drive claiming that corn-fed beef would have a superior taste.

Beef that is consuming GMO corn

This link shows that the producers only care about their profit and how much of corn-fed beef they can sell. They do not mention that corn is a GMO crop, so this feed is somehow incorporated into the meat. No one has done long-term experiments to ensure that this meat is safe to eat. Moreover, we do know from measurement that corn-fed meat contains much less omega-3 fatty acids and much more omega-6 fatty acids than grass-fed beef. Cows are meant to be grass-feeding animals.

Avoid hamburger meat and bacon

If you want to stay healthy, eat grass-fed beef, but do not consume too much or you put yourself at risk for gout from purine metabolites. Corn-fed and grain-fed beef cattle have a lot more infections including liver disease. To control this, the animals are receiving antibiotics. These antibiotics end up in the meat, which can produce superbugs. These superbugs can enter into humans through the food chain.

Bacon is another food that is not only full of saturated fat, but it contains additives, such as sodium nitrite. Give the matter some thought before you put hamburger meat and bacon into your shopping wagon!

What’s wrong about potato chips, cookies, and cornflakes?

1. Potato chips

Potatoes are rich in carbs, but they are empty carbs. Their glycemic index is in the 70 to 80 ranges. I avoid any carbs that exceed 55 (the upper limit of the low-glycemic index). Strangely enough by the time the potatoes have undergone the process of becoming potato chips, the glycemic value is only 51, but this is deceiving. Fat and salt have also entered the potato chips. We now have a product that surely will be bad for your arteries and cause high blood pressure over the long haul. Another important fact is that potatoes belong to the 12 dirty dozens fruit and vegetables that are heavily sprayed with pesticides (see below).

2. Cookies

Cookies are a mix of various ingredients. Here is a recipe for cookies. This is even a better than average quality cookie recipe as they used unsalted butter as a fat source. In many recipes they use margarine, which is an inferior fat. It contains free radicals from the manufacturing process. It is derived from omega-6 fatty acid vegetable oils. But the worst ingredients of cookies are the nutritionally empty white flour and the sugar. Both together are digested, absorbed as sugar into your blood, and a huge insulin response occurs after you have eaten it. Even the cheap chocolate used for the chips is full of unhealthy table sugar causing your pancreas to overproduce insulin.

3. Cornflakes

As mentioned above corn is a GMO crop and we do not know the long-term effects of GMO food on humans. There are more and more reports about gut dysbiosis, leaky gut syndrome and autoimmune diseases as a result of the breakdown of the gut barrier. Pro-GMO advocates deny these possibilities. I play it safe and stick to organic fruit and vegetables. But cornflakes are also high on the glycemic index (between 77 and 93). Usually the food industry mixes sugar into it, and the starchy component consists of empty calories. It is simply not a sensible food choice!

The dirty dozen: grapes, celery, peppers, strawberries and apples

It is common knowledge for some time that certain foods contain pesticides than others. Some of these fruit and vegetables contain between 13 and 15 different pesticides from spraying, as this link describes. Potatoes are one of the crops with the most contamination among the dirty dozen.

You may ask, why is it important to know which crop has contamination with pesticides? Pesticides are immune disruptors. Vegetables that are supposed to be healthy for us contain residues from insecticides and herbicides that have estrogen-like activities called xenoestrogens.They are known to cause breast cancer in women and prostate cancer in men.

Breaded chicken strips, milk and fruit yogurt

1. Chicken strips

Chicken are fed arsenic type antibiotics for faster growth.

The only way how to protect yourself from this contamination is by buying organic chicken, which I have done since 2001. Also, don’t buy breaded “anything” This brings us back to the wheat story mentioned under “White bread and pizza” above.

2. Milk

Milk in the US often contains antibiotics and genetically modified bovine growth hormone (rBGH), which can cause various cancers in humans as this link shows. Europe and Canada banned recombinant bovine growth hormone.

3. Yogurt

Most people like fruit yogurt, which is full of sugar and fruit syrup. Plain yogurt, sweetened with a bit of stevia is healthy. But the moment it the food industry adulterates yogurt with minimal amounts of fruit, and high amounts of sugar, this “fruit yogurt” leads to weight gain and hardening of arteries. The best yogurt product is organic 1% or 2% plain yogurt. Use fruit of your choice to make a real fruit yoghurt!

What Your Shopping Cart Reveals

What Your Shopping Cart Reveals

Conclusion

Life is all about decisions. I like to make healthy food choices for myself. When I go grocery shopping, I notice that many people do not seem to give much thought to what they are purchasing. They likely also have never read the details about the type of facts I mentioned above. The ingredients that people buy at the grocery store are the ingredients of the Standard American Diet, a sad state of affairs indeed.

The key is to avoid wheat products because Clearfield wheat leads to leaky gut syndrome and autoimmune diseases. Next avoid processed foods and added sugar. What I have not mentioned above is the importance of cutting down on omega-6 fatty acids and to increase omega-3 fatty acids (fish, fish oil supplements). Omega-3 fatty acids are anti-inflammatory. Omega-6 fatty acids stimulate the arachidonic acid pathway leading to hardening of arteries and arthritis. This leads to stents of the coronary arteries and joint replacements of the hips and knees.

The dirty dozen

Avoid the dirty dozen of crops and buy them organic instead. Avoid milk products in the US; instead buy them organic to avoid exposure to recombinant bovine growth hormone.

It takes a bit of homework and re-education to eat healthy foods. Start reading labels! If a ten year-old cannot read the name of an additive, it should most likely be a signal for you not to buy this product! The more processed food is, the less nourishing it is likely to be. It is not a huge effort to educate yourself about products, but it does take time to steer away from old habits that are not the best for your health. Ultimately your efforts will pay dividends in terms of good health for years to come!