Nov
10
2015

Sugary Soda Drinks Make You Sick

By | Alzheimer’s disease, Cancer, Cardiovascular disease, heart attack, Heart Disease, Inflammation, Nutrition, Stroke

Dr. Frank Hu and colleagues have recently re-examined the old question of whether sugary soda drinks make you sick. They usually contain high fructose corn syrup, a mixture of 55% fructose and 45% glucose. This sugar mix can be found in sugary soda drinks as well as in many processed foods like fruit spreads. Dr. Hu’s publication is listed in PubMed , but details can be found in this summary.

The study found that one or two cans of sugary soda drinks per day lead to

  • As high as a 26 percent greater risk of developing type 2 diabetes,
  • A 35 percent greater risk of heart attack or fatal heart disease, and
  • A 16 percent increased risk of stroke.

Difference in metabolism between fructose and glucose

The study also found that there is a difference of how glucose, the main sugar that the body uses for energy is metabolized versus fructose from high fructose corn syrup or the breakdown of table sugar, a disaccharide consisting of glucose and fructose combined as one molecule. Glucose gets directly absorbed from the gut into the blood circulation and with the help of insulin gets further absorbed directly into body cells. In contrast the liver metabolizes fructose into triglycerides, which can cause fatty liver disease and insulin resistance. Fructose also raises the bad cholesterol (LDL cholesterol). This in turn is a risk factor for developing diabetes, heart attacks and strokes.

It is fructose in sugary drinks and processed foods that are largely responsible for weight gain, metabolic syndrome, diabetes and cardiovascular disease.

The newest finding: heart failure can also be caused by high fructose corn syrup

A study in Sweden has recently shown that sugary drinks can cause heart failure. Researchers followed 4200 Swedish men for 12 years in regard to their food habits. The study found that the men who drank at least two sweetened drinks per day had a 23% higher risk of developing heart failure. Dr. Susanna Larsson, a co-author of the study, said: “The takeaway message is that people who regularly consume sweetened beverages should consider limiting their consumption to reduce their risk of heart failure”. Heart failure affects nearly 6 million Americans. It develops either on its own in persons with inadequately treated high blood pressure or in people who had a previous heart attack. It is a condition, which disables the heart to effectively pump enough blood with nutrients and oxygen into the tissues.

Symptoms of heart failure

People who develop this condition feel the symptoms: they get short of breath with minimal activity. They also may wake up short of breath in the middle of the night. It is a miserable life, as people with heart failure experience severe restrictions in their daily activities. Even walking a flight of stairs becomes a struggle or even an impossible task. Total disability is the next step. The key is prevention: do not use high fructose corn syrup, and stay away from sugar in any form; instead use stevia to sweeten your food when needed.

Be careful how you replace saturated fatty acids

Dr. Frank Hu has also participated in a study that spanned over 24 to 30 years and examined the replacement of saturated fat with polyunsaturated fatty acids (PUFA), monounsaturated fatty acids and whole grain carbohydrates. The study involved 84,628 women (Nurses’ Health Study, 1980 to 2010), and 42,908 men (Health Professionals Follow-up Study, 1986 to 2010). Detailed questionnaires assessed the diet every 4 years. 7,667 cases of cardiovascular disease (CHD) occurred during the long observation times. Compared to controls that did not change their diet with respect to saturated fatty acid intake, those who replaced with PUFA had 25% less CHD, those who replaced with monounsaturated fatty acids had 15% less CHD and those who replaced saturated fatty intake with whole grains had 9% less CHD. A subgroup that had replaced saturated fatty acid intake with carbohydrates from refined starches/added sugars ended up with a 10% increase of CHD.

Cutting fructose out of diet lowers cholesterol and weight

A new study by Dr. Robert Lustig and colleagues from the University of California, San Francisco showed on 43 children that a change of diet reducing dietary sugar from 28% to 10% and replacing it with other complex carbohydrates led to a significant reduction in triglycerides, cholesterol and blood pressure.

The nucleus accumbens in the brain is the reward center for addictions

The fructose stimulus was taken away, which stimulates a part in the brain, called nucleus accumbens, where the reward center is located. This is the reason why the more sugar you take in, the more addicted to sugar you become. Not surprisingly when physicians changed the diet, there were internal signs of improving with regard to blood tests. But physically the children also showed weight loss just within 10 days as their total calorie intake had reduced. There is another observation with regard to fructose metabolism. Normally after a meal there is suppression of ghrelin, the hunger hormone. But when you drink a sugary drink with fructose in it, there is no suppression of ghrelin. The result is that you do not feel satisfied and you keep on consuming fructose containing drinks resulting in weight gain.

Sugary Soda Drinks Make You Sick

Sugary Soda Drinks Make You Sick

Conclusion

What we eat matters in terms of long-term consequences. This is certainly true for refined sugar intake. Don’t lull yourself into the belief that honey is “healthy”. Even though it is a natural product, your body treats it according to its chemical composition. It is sugar, and unfortunately it will get you into health problems naturally. Even the fashionable agave syrup contains largely fructose: again, this is bad news for your health! No matter what type of sugar you choose, the long-term consequences have haunting qualities. Consequences of sugar intake are weight gain, diabetes, heart attacks and strokes. You will agree that is not worth to take any of these risks just to satisfy a sweet tooth.

Alternatives to sugar

Biting into a crisp, sweet apple is enjoyable and has never harmed anybody. Eating a small helping of fruit salad to top off a meal can be a delicious finale to dinner. If you need a sweetener, it is better for you to use the plant-derived stevia, which is available as a powder or a liquid. Smallest quantities are adequately sweetening foods. Stevia has no calories and none of the consequences of sugar: you’ll enjoy the sweetness without the bitter aftereffects of tooth decay or heart disease!

Nov
07
2015

Eat Your Avocado

By | Anti-aging medicine, Arthritis, Cancer, Cardiovascular disease, Health, heart attack, Heart Disease, Nutrition, Obesity, Stroke, Vitamins and supplements

“Eat your avocado” is an appropriate invitation to eat this super food with many positive effects on people’s health. That is to say, first, it helps arthritis, in addition it is good for your vision, besides it protects against cardiovascular disease, moreover it fights metabolic syndrome, further it helps in weight maintenance and finally, it even protects against some cancers. Avocado contains healthy oils and many vitamins and minerals.

Avocado composition

80% of an avocado is fiber making it a valuable food to prevent colon cancer. Among the minerals it is noteworthy that avocados are rich in boron and potassium. In terms of vitamins it is rich in vitamin E (alpha-tocopherol), vitamin B6, folate, vitamin K and pantothenic acid. It does not contain cholesterol, but contains monounsaturated fat (oleic acid). In fact, oleic acid is the compound in olive oil responsible for lowering your blood pressure. The oils in avocado contain first 71% monounsaturated fatty acids, secondly 13% polyunsaturated fatty acids and thirdly 16% saturated fatty acids. This mix promotes healthy blood lipids, but also helps in the absorption of fat-soluble vitamins and phytochemicals. In addition to all that avocados contain phytosterols, a number of carotenoids, non-carotenoid antioxidants, alpha-linolenic acid (an omega-3 fatty acid) and glutathione.

Cardiovascular disease protection

The combination of fiber and folate in avocado help to reduce LDL cholesterol. Oxidized LDL leads to hardening of arteries. The folate reduces homocysteine, which is a risk factor for heart disease. Phytosterols that are similar in structure to cholesterol compete with cholesterol absorption in the gut.

In a 2015 study several diets were compared with regard to LDL lowering potential, either a low fat diet, or two forms of medium fat diets, where one contained one avocado per day. The results were surprising in that the low fat diet led to a reduction of LDL by 7.4 mg/dL while the avocado diet caused a reduction of LDL by 13.5 mg/dL.

The oils in avocados also seem to suppress the appetite center in the brain helping people to eat less and controlling obesity and diabetes.

Arthritis prevention

In a 2014 study hip osteoarthritis was examined for over 3 years. Researchers could show that an extract from avocados and soybeans was protective of osteoarthritis. The anti-inflammatory components of avocado like omega-3 fatty acids, carotenoids, phytosterols and non-carotenoid antioxidants all work together in countering joint inflammation. Boron abundantly contained in avocado also was found to be essential for healthy joints.

Eye protection

Avocado has its own mixture of carotenoids, like alpha- and beta-carotene, lutein, zeaxanthin, neochrome, chrysanthemaxanthin and others. The green pulp contains these. They have anti-inflammatory properties. The fatty acid profile of avocados helps to absorb carotenoids, as they are fat-soluble. Researchers conducted a a two phase clinical study to show that avocado added to salsa or to salad was leading to a 5- to 15-fold higher absorption of the carotenoids in salsa and salad when compared to avocado-free salsa and salad.

This is an important observation that we should remember: always eat some avocado with any fruit or vegetable that contains carotenoids, as this will improve the absorption of the carotenoids tremendously.

Why is that so important for eye disease? In a 2008 study a total of 1802 women aged 50 to 79 years from Iowa, Wisconsin, and Oregon were followed who had intakes of lutein and zeaxanthin above the 78th percentile. Researchers compared these women to women below the 28th percentiles in the Women’s Health Initiative Observational Study. This involved eye examinations in both groups. The eye specialists examined their eye lenses for nuclear cataracts. The surprising finding was that women with the highest quintile category of diet or serum levels of lutein and zeaxanthin had 32% less nuclear cataracts than women in the lowest quintile of lutein and zeaxanthin.

The conclusion was that carotenoids of avocados have vision protective effects.

Metabolic syndrome and obesity

This 2013 study included 17,567 US adults and part of the National Health and Nutrition Examination Survey (NHANES) 2001-2008. Researchers compared avocado eaters and non-avocado consumers. Interestingly, avocado eaters had a much better overall food quality in their diet. They ate more vegetables, fruit, fiber and less added sugar. Calorie and sodium intake were identical in the two groups. But body weight, body mass index and waist circumference were significantly lower in avocado eaters than in the non-avocado control group. The cardio protective HDL cholesterol was significantly higher in the avocado group. The odds ratio for developing metabolic syndrome, the change in metabolism due to obesity was 50% lower in avocado consumers than in non-consumers. All of this is good news for the consumer, if we eat some avocado.

Skin, beauty and anti-aging

We don’t like to develop too many wrinkles, as they are a sign of premature aging. The oils of avocados have been used for some time in skin care products as they stimulate collagen production in the skin and reduce wrinkles. But when you eat avocados, the carotenoid substances (such as lutein and zeaxanthin) serve for skin protection, protecting you from UV light damage. In addition, avocados contain vitamin E and glutathione, which help to scavenge free radicals. Otherwise the skin would prematurely age and wrinkle. The end result is that you see a reduction in the development of wrinkles, when you consume avocados. The beneficial effects on your blood vessels in combination with protecting your skin will age your body slower, a point that has been noted in the anti-aging literature.

Cancer blocking properties

In the following I will briefly review the findings of several cancer research groups, but this review is by no means complete.

Leukemia

This 2015 study describes a new chemotherapeutic agent, derived from avocado that they named Avocatin B. Avocatin B is active against the difficult to treat acute myelogenous leukemia (AML). It works by targeting mitochondrial components of AML, but does not affect healthy leukocytes or leukocyte progenitor stem cells.

Colon and esophageal cancer

The authors of this study from Iran describe four phytoextracts of avocado for treatment of patients with esophageal cancer and colon cancer. They noted that the phytoextracts have a much lower toxicity than standard chemotherapeutic agents and significantly slow growth of these cancers. They plan to use these phytoextracts as complementary treatments of esophageal and colon cancers.

Oral cancers

This paper describes that avocado extracts were shown to be successful in treating oral cancers.

Cancer prevention

In this paper it is discussed that the phytochemicals in avocados arrest cancer cells in their cell division cycle and lead to apoptosis, which is natural cell death. The authors believe that eating avocado regularly can help prevent a whole array of different cancers by this mechanism.

Eat Your Avocado

Eat Your Avocado

Conclusion

Avocados are a super food, which has many beneficial effects. Perhaps one of the outstanding effects is prevention of obesity and the metabolic syndrome as discussed. Women may want to eat it because of the beneficial effects on skin and beauty. We all should have an interest in wanting to prevent heart attacks, strokes and cancer.

But who does not want to prevent cataract surgery and keep good vision until a ripe old age? It is possible by eating avocados. And would you not want to prevent osteoarthritis? Eat avocados and add some omega-3 fatty acid from distilled fish oil as well to get the full anti-inflammatory effect. Your joints will thank you and let you swiftly move wherever you want to go.

I thought you should know about the health benefits of eating avocados. They make a nice addition to your food, not only as guacamole, but in a wide variety of dishes. Use a few slices on your salad. Make a tasty dip. And find inspiring recipes online that you can easily find and copy.

Sep
19
2015

Obesity Shortens Life

By | Cancer, Cardiovascular disease, Diabetes, heart attack, Heart Disease, High Blood Pressure, Inflammation, Mortality, Nutrition, Obesity, Smoking, Stroke, Weight loss

This article is about the fact that obesity shortens life. Of all the factors that definitely shorten life, obesity stands out like a giant. Let’s review a couple of facts regarding obesity:

  1. Americans who were born between 1966 and 1985 became obese at a much earlier age than their parents
  2. Obesity occurs at a younger age than in the past. 20% of people born between 1966 and 1985 were obese in their 20s.
  3. The longer you are obese, the higher the chance of getting seriously sick or dying prematurely from complications of associated diseases like diabetes, heart attacks, strokes, kidney disease, liver disease and cancer.
  4. Severely obese people live up to 20 years less than non-overweight people.
  5. Obesity causes about 300,000 deaths in the U.S. annually

Change of metabolism

Obesity shortens life. Obesity leads to a change in metabolism, which is known as metabolic syndrome. The liver changes its metabolism slightly producing more triglycerides, LDL cholesterol and clotting factors, which increases the risk for heart attacks, strokes and pulmonary emboli. The pancreas produces more insulin, which gives rise to reactive hypoglycemia. This means that 2-3 hours after a meal you become hungry as your blood sugar declines from the extra insulin. You are craving a sugary drink, a donut or other starchy food (pizza, fries, bread etc.). Unfortunately, these types of foods reinforce the metabolic syndrome: the liver changes the sugar into LDL cholesterol and triglycerides.

Excess sugar oxidizes LDL cholesterol

Excess sugar will oxidize the LDL cholesterol, which causes atheromas (hardening of the arteries). Protein is being caramelized, which is called “advanced glycation end-products” or AGEs. This reference clearly explains how to counter this: increase your consumption of fish, legumes, vegetables, fruits, low-fat milk products and whole grains; also reduce your intake of solid fats, full-fat dairy products, fatty meats, and highly processed foods. There are other hormone changes that take place in obese people.

Death statistics due to obesity

In this study 849 autopsies were performed over 10 years, of which 32.3% were of obese persons. Leading causes of deaths in obese people were: malignancy (31.4%), infection (25.9%), ischemic heart disease (12.8%), pulmonary embolism (6.2%) and liver disease (2.9%). Table 2 of this link shows the causes of death in non-obese individuals as well: malignancy (32.5%), infection (23.8%), ischemic heart disease (10.4%), pulmonary embolism (2.9%) and liver disease (0.7%). The figures do not look all that different except that liver disease and pulmonary embolism are significantly more often the cause of death in obese patients than in normal weight patients. What you do not see in these figures is that obese people get these conditions at a much younger age as a result of complications from the associated diseases like diabetes, high blood pressure, cardiovascular disease, osteoarthritis, kidney disease and liver disease.

Diabetes

The metabolic changes with regard to the metabolic syndrome include insulin resistance.

As obesity worsens the balance is lost where the body can compensate and type 2 diabetes develops with increased blood sugar values and symptoms of diabetes. Surprisingly with regular exercise and changes in food intake (adopting a low glycemic index diet) this can be treated successfully. Usually this change is also associated with some weight loss, which helps to stabilize the metabolism. If nothing is done to to change diabetes, there is a high risk for heart attacks, strokes and subsequent secondary conditions like diabetic nephropathy, retinopathy, diabetic neuropathy and vascular complications.

Uncontrolled high blood pressure

High blood pressure is part of the metabolic syndrome. Unfortunately in obesity it is often difficult to control and may require several different antihypertensive medications in combination to control it. One way to quickly get the blood pressure under control is to make a concentrated effort to reduce a few pounds of weight; this can be achieved by cutting out refined carbs and sugar and starting an exercise program of walking and swimming.

Smoking

Smoking continues to remain a problem. Men as a group are now smoking less while women are increasing their smoking rates. Smoking causes various cancers, but also increases death rates from heart disease and strokes. In connection with obesity it is clear that the obese smoker has the highest risk of dying prematurely. This is depicted in this link based on the original Framingham study.

Disabilities and nursing homes

Obese people get disabled earlier, ending up in nursing homes. This poses a huge problem there for the staff. Back injuries and disabilities in the caregivers of nursing homes have increased significantly in the last few decades.

Osteoarthritis

80% of hip replacements and 90% of knee replacements are due to osteoarthritis. Obesity is the strongest modifiable risk factor that leads to osteoarthritis and subsequent surgery. There is a lot of morbidity and mortality associated with total knee and total hip surgeries. Part of this is the susceptibility to clot formation from the changes in metabolism associated with the metabolic syndrome. This often leads to pulmonary emboli and higher death rates following surgery when compared to surgery in people with normal weight.

Heart attacks and strokes

As there is an increase of the amount of heart attacks and strokes in overweight and obese people it is important to reduce your BMI when you realize that it is creeping up. Regular exercise along with a Mediterranean diet helps to improve this. Avoid processed foods that often have hidden sugar and refined carbs in them. Also cut out sugar. Use stevia, a natural sweetener, if you want to sweeten your food or drinks.

Nonalcoholic fatty liver disease (NAFLD)

In the past nonalcoholic fatty liver disease was rare. Now with the increase of obesity it is common. It can lead to liver cirrhosis with hepatic failure, a common cause of death. But after several years of liver cirrhosis, liver cancer may develop within the cirrhotic liver. Physicians saw this condition only rarely in decades past.

Obesity shortens life: Kidney disease

With obesity there is a negative effect on the kidneys from the metabolic syndrome. Hyperinsulinism affects the capillaries of the filtration units, called glomeruli. They start to proliferate and undergo a form of degenerative change, called glomerulosclerosis. This decreases the filtration capacity of the glomeruli and the kidneys as a whole. After a few decades of this process kidney failure can set in. When an obese person develops diabetes, this will also have a negative effect on kidney function and accelerate the deterioration of kidney function. The end result is kidney failure, which requires dialysis or a kidney transplant.

Cancer and obesity

Obesity shortens life. Chronic inflammation that is worsened by the metabolic syndrome leads to higher rates of various cancers. A prospective study of more than 900,000 US adults was conducted for 16 years. In 1982 when the study was started none of the participants had cancer. After 16 years 57,145 of the study participants had died of cancer. Those in this study who had a BMI of 40.0 or more had cancer death rates that were 52% higher for males and 62% higher for females when compared to normal weight men and women.

Higher cancer rates in people with obesity

It was noticeable that the digestive tract showed higher cancer rates in the obese: esophagus, liver, gallbladder, pancreas, colon and rectum; other more frequent cancers were kidney cancer, multiple myeloma and non-Hodgkin’s lymphoma. There were also trends of higher cancer death rates with regard to cancer of the stomach and prostate in men and breast cancer, uterine cancer, ovarian and cervical cancer in women. The authors concluded that due to the rising obesity rates in the US population cancer rates in men will soon reach the 14% level and in women the 20% level out of the total death rates.

Treating obesity

Treatment of obesity requires a multifaceted approach. I have discussed this in detail in this blog. Briefly, the diet of the obese person needs to be closely looked at. Sugar and starchy foods need to be eliminated. Low glycemic foods like vegetables, lean meat and salads should be encouraged. A regular exercise program needs to be instituted, starting with swimming and walking. Later a gradual transition into gym type activities could be contemplated.

Weight loss surgery has been successfully applied in some obese patients with a BMI that is greater than 30.0 up to a BMI of 39.9. In a 5-year follow up after LAP-band surgery no surgical complications were reported and the mean percentage weight loss was 15.9±12.4%.

Obesity Shortens Life

Obesity Shortens Life

Conclusion

Obesity shortens life. Obesity is a condition that has been gradually developing since the 1980’s. When you look at the food intake changes rationally it is not surprising that this is happening. Sugar consumption, high-fructose corn syrup consumption and the consumption of processed food have to be cut down, if not cut out completely. You can forget shopping at the middle section of any grocery store, where all that processed food is located. Go to the vegetable section and buy a lot of food from there. Low fat dairy products, eggs, and low-fat meats as well as salmon and other seafood are foods that are healthy. There is one problem though and that is the feeding of antibiotics to chickens, turkeys and beef cattle. This leads to superbugs and changes your gut flora.

Eat organic foods

I suggest you buy organic meats. I eat organic food and have cut out wheat also as wheat underwent forced hybridization in the 1970’s. All of the wheat in the world now is this type of wheat that is too rich in gliadin, which causes leaky gut syndrome and autoimmune diseases. For this reason, I avoid all wheat.

Gradually shed your pounds

I see no reason why obese people could not gradually shed their pounds and regain their stable metabolism. Those with diabetes will be able to shed that diagnosis as they shed their pounds. The kidney and liver function will also stabilize when you shed enough pounds. The goal should first be to reach a BMI of 25.0 to 30.0, which is the overweight category. The next goal would be to aim for shedding even more pounds until you reach a BMI of fewer than 25.0. If you say this is too tough to do, I am saying: giving up is not an option. Cherish your health!

Sep
12
2015

Ageless Aging

By | Anti-aging medicine, Arthritis, Cancer, Cardiovascular disease, fractures, heart attack, Hormones, Inflammation, lifestyle, Menopause, mitochondria, Nutrition, Osteoporosis, Prevention, Vitamins and supplements

We have been exposed to a lot of clichés about aging, which makes it more difficult to dispel rumors and to clearly focus on what can and what cannot postpone aging and the associated disabilities. Here I will attempt to summarize what is known about this topic.

The American Academy of Anti-Aging Medicine (also known as A4M) has published a book where all of this is discussed in detail (Ref.1). But there are yearly conferences as well in Las Vegas and other places where further details regarding anti-aging are discussed. Since 2009 I have been attending the conferences in Las Vegas regularly every year.

Based on this knowledge let me start by reviewing the tools of anti-aging that can be used to slow down the process of aging significantly.

  1. Mitochondria

At the center of anti-aging is the preservation and metabolic optimization of the mitochondria. Each of our cells contains little particles called mitochondria, which is where our energy metabolism takes place. Mitochondria function like mini-batteries.

The citric acid cycle builds up ATP, which is subsequently hydrolyzed into ADP and orthophosphate releasing energy for cell metabolism.

Old people who shuffle when they walk and have difficulties climbing stairs have lost significant amounts of mitochondria and simply run out of energy. The key to prevent this from happening is to preserve our mitochondria. We inherited them from our mother, because only the head of the sperm, which does not contain mitochondria entered the ovum when the egg cell that was destined to become you was fertilized. Subsequently the mitochondria from mother’s egg have provided all of the mitochondria in the cells of our body.

  1. Preserving mitochondria

There are supplements that specifically preserve mitochondria: PQQ (=Pyrroloquinoline quinone) helps mitochondria to multiply. A typical dose to take every day is 20 mg. Mitochondrial aging is slowed down by ubiquinol (=Co-Q-10, 400 mg per day is a dose that I recommend). Co-Q-10 repairs DNA damage to your mitochondria.

There are simple lifestyle changes that you can make: eat less calories as this will stimulate SIRT1 genes, which in turn stimulate your cell metabolism including the mitochondria.

Resveratrol, the supplement from red grape skin can also stimulate your mitochondria metabolism. 300 to 500 mg of trans-Resveratrol once daily is a good dose.

Build in regular exercise into your day – and I mean every day– as this will also stimulate your mitochondria to multiply similar to the effects of PQQ. Lipoic acid is an anti-oxidant that counters the slow-down of mitochondrial metabolism. I recommend 300 mg per day.

L-arginine is an amino acid that is a precursor of nitric oxide (NO). Red beet is a rich source of nitric oxide, which is directly released into your system. There are also commercial products for NO. This keeps the arteries open, prevents high blood pressure and also hardening of the arteries and has a direct effect on preserving mitochondria.

Researchers from the McKusick-Nathans Institute of Genetic Medicine of the Johns Hopkins University School of Medicine in Baltimore, MD found that mitochondrial DNA content varies according to age (less mitochondrial DNA in older age), sex (yes, women have more than men) and mitochondrial DNA; it even has an inverse relationship to frailty and a direct relationship to life expectancy. This paper was published in February of 2015.

Each mitochondrion has its own mitochondrial DNA contained in 2 to 10 small circular chromosomes that regulate the 37 genes necessary for normal mitochondrial function.

In multi ethnic groups it was apparent that mitochondrial DNA content was dictated by the age of a person.

Frailty was defined as a person who had aging symptoms including weakness, a lack of energy compared to the past, activity levels that were much lower than before and loss of weight. When persons with frailty as defined by these criteria were identified, they were found to have 9% less mitochondrial DNA than nonfrail study participants.

Another subgroup were white participants; when their bottom mitochondrial DNA content was compared to the top mitochondrial DNA content, the researchers found that frailty was 31% more common in the bottom DNA content group. This means that white people are more prone to frailty and they should take steps early on to prevent this from happening.

  1. Slowing down hardening of our arteries

It makes sense that young people who do not have signs of hardening of their arteries have better blood supply to their cells and thus supply their mitochondria with more oxygen and nutrients than frail, older people. The same is true for people who exercise regularly.

Vitamin D and vitamin K2 have been shown to lower calcium in the blood vessels and to retain calcium in the bone preventing osteoporosis. This is particularly useful in postmenopausal women. This October 2014 publication mentions that apart from vitamin D and vitamin K2 resveratrol and inositol are additional factors helping to prevent heart disease and osteoporosis.

This September 2013 publication confirms that a deficiency for vitamin K2 is common in the general population. This deficiency leads to osteoporosis and calcification of the arterial wall and causes heart attacks, strokes and bone fractures. Supplementation with vitamin K2 at 200 micrograms per day every day is recommended to prevent this from occurring.

  1. Sugar and starchy foods

You need to understand that starchy foods equal sugar, once digested. As a result a refined cereal breakfast=sugar, pasta=sugar, bread=sugar, donuts=sugar, potatoes=sugar and so on. It has to do with the glycemic load. When you cut out sugar and starchy foods (meaning that the glycemic index of the foods you eat is below 50) you will shed 30 to 50 pounds of weight within 3 to 5 months, if you are overweight or obese. You will feel a lot more energy. Your blood vessels will be cleaned out as the oxidized LDL cholesterol will disappear and the HDL cholesterol will mop up what cholesterol deposits were there before.

It is certainly good for you, if you are not into the sugar and candy stuff, but the seemingly harmless pizza and all the other starchy foods mentioned above are of concern as well. All of the high -glycemic carbs stimulate the pancreas to produce insulin. This in turn produces inflammation in tissues including the brain. Alzheimer’s disease is one of the complications of this.

Where does this leave us? For decades we have been told that saturated fats and cholesterol in our diet were the culprits and we replaced them with sugar that is part of a low-fat diet. We need to pay attention to the glycemic index and cut out high glycemic foods. However, it is OK to eat some carbs from the medium glycemic food list and most of our carbs from the low glycemic food list. With regard to fat it is important to consume only the healthy fats like olive oil, coconut oil and omega-3 fatty acids. As you make these adjustments to your life style you will also prevent many cancers, as you normalize the body’s metabolism and help prevent chronic inflammation, which can cause arthritis and cancer. Finally, pay attention to stress management. The body and the mind work together. Uncontrolled stress leads to heart attacks and strokes.

  1. Cut down on processed foods

Processed foods contain the wrong type of vegetable oils that are composed of omega-6 fatty acids. This disbalances the ratio of omega-6 fatty acid versus omega-3 fatty acids. This is typical for all the processed foods, but also fast food places in the industrialized world. The consequence of this disbalance is the formation of arachidonic acid and inflammation of tissues. This causes high blood pressure from inflammation of the arteries, arthritis from inflammation in the joints and can irritate the immune system to the point of causing autoimmune diseases. The end result after decades of exposure to a surplus of omega-6 fatty acids are disabilities from end stage arthritis, as well as heart attacks and strokes from inflammation of the arteries due to the hardening of the arteries.

The remedy for this is to cut out all processed food and stick to the basics of preparing your own food from healthy ingredients with no food preservatives.

Use olive oil for salads and coconut oil for cooking. Take omega-3 supplements to restore the omega-6/omega-3 fatty acid balance.

  1. Replace hormones with bioidentical ones

When I watch postmenopausal women, many look prematurely aged with sagging skin in their faces. Had they replaced their missing hormones when they entered menopause, the bioidentical hormones used for replacement therapy would have helped their skin to remain younger looking, hardening of the arteries would have been postponed and osteoporosis in the bones would also have been prevented.

With men it is now known that testosterone is vital for prevention of prostate cancer, but it is also important to prevent heart attacks, strokes and dementia as they age.

I would recommend that you see a naturopath or an anti-aging physician to have your hormones checked and if necessary start replacement with bioidentical hormones.

Ageless Aging

Ageless Aging

Conclusion

Slowing down aging and avoiding disabilities from aging are now a possibility, if we manage our lives in a way that the biochemistry of our bodies remains the same and our mitochondria continue to function, even when we get older. I discussed the details of how to do that above. I have also written a book on the subject of anti-aging, which deals with these topics in more detail.

I hope that you incorporate at least some of these steps in your life to prevent suffering from disabilities as you age and to avoid premature aging.

References:

Ref.1: Ronald Klatz, MD, DO and Robert Goldman, MD, PhD, DO, FAASP, Executive Editors: “Encyclopedia of Clinical Anti-Aging Medicine & Regenerative Biomedical Technologies”. American Academy of Anti-Aging Medicine, Chicago, IL, USA, 2012.

Aug
29
2015

Problems With The Western Diet

By | Cancer, Cardiovascular disease, Diabetes, Fitness, heart attack, Heart Disease, Inflammation, lifestyle, Nutrition, Prevention

Lately there have been various news reports cautioning us about the Western diet. We eat too much processed food, we eat too much sugar and we have to be careful with how much fat and what kind of fat we eat. Take this story from the CNN. Half the world lives in big cities. And this number will reach 70% in the year 2050, if the urbanization trend continues at the same rate. With it comes the consumption of fast food. The wealthier people are, the more meat they eat. This is exactly what is bad for us. Too much meat can cause gout, particularly when paired with alcohol. First it is time to explain some more about the Western diet. “The biggest features of a Western diet are overconsumption of over-refined sugars, highly refined and saturated fats, animal protein and a reduced intake of plant-based fibers,” says Ian Myles. He is located at the U.S. National Institute of Allergy and Infectious Diseases. This statement is specific enough: we are eating too much fat, red meat, salt and sugar, and too little fiber.

Too much fat

In processed foods we get too many omega-6 fatty acids, which have been shown to cause clogging of arteries and causing heart attacks and strokes, if not balanced with enough omega-3 fatty acids. But many processed foods still have hidden trans fats, which distribute free radicals in your system; this in turn causes hardening of the arteries again. Free radicals also age you faster. A candy bar with palmitic acid and fructose for instance, leads to a slow grade inflammation. The immune system mistakenly takes palmitic acid for the gut bacterium E.coli and mounts an immune reaction. This low-grade inflammation causes inflammation in the blood vessels, but also weakens the immune system. The sugar part of the candy bar oxidizes LDL cholesterol leading to clogging of arteries, which causes heart attacks and strokes.

Too much red meat

Grain fed and antibiotic treated regular beef changes the gut bacteria and can cause super bugs. The change of the gut flora can lead to inflammation in the gut lining and something called “leaky gut syndrome”. We carry almost 2 pounds of gut bacteria in us at any given time. But residual antibiotics from regular beef and chicken reduces that amount and changes the composition of our gut flora.

You can read in this blog that the changes taking place from consuming regular beef changes your liver metabolism and leads to accelerated hardening of the arteries, which in turn causes deadly heart attacks and strokes. On the other hand, grass fed beef or organic beef do not do this. To prevent leaky gut syndrome, heart attacks and strokes from developing you can take probiotics every day, which should include these two species: Lactobacillus acidophilus and Bifidobacterium bifidus. This keeps your gut flora stable and does not allow your food to undermine your health.

To much salt and sugar

Too much salt is often in processed food to prolong the shelf life. But we humans are very sensitive to overdoses of salt. Our kidneys have to work overtime to get rid of the excess salt. We need to drink enough water to allow the kidneys to produce urine, which will eliminate the excess salt. Persistent excessive salt intake will also cause high blood pressure. High blood pressure can cause heart problems, strokes and aortic aneurysms. Restaurant food often contains too much salt and sugar.

Too little fiber

The more food is processed, the less fiber it will contain. If you go for the pizza, it may taste good, but where is the fiber? If you eat bread and butter, where is the fiber? You may say that you like a donut. I ask you again: where is the fiber? The end result is that toxins that normally would have been bound to fiber in the colon and were eliminated in the stool are now interacting with the wall of the colon causing colonic polyps and colon cancer. It may not only be fiber as plant-based diets rich in fruits, non-starchy vegetables, legumes, and whole grains were shown to be associated with a lower risk of the most common cancers. That’s the reason why people who consume a Western diet have higher rates of cancer in general. They lack fruits and vegetables.

Polyunsaturated fatty acids

The recommendation in the 1980’s until about 2010 of a low fat diet to prevent heart attacks and strokes has failed miserably. It turned out that polyunsaturated fatty acids are of the omega-6 type, which gets metabolized into arachidonic acid and causes inflammation. The immune system gets suppressed from the chronic inflammation and the person becomes more prone to infections. As low fat diets are typically high in carbohydrates, there is a calorie surplus causing weight gain. Dr. Fife explains in his book that polyunsaturated acids interfere with the insulin receptor feeding into insulin resistance, which makes it even more difficult to control the metabolism and leads to more weight gain (Ref.1). The end result is what we have observed over the last few decades, a relentless obesity wave in the civilized world. It is a direct result of the Western diet.

Cancer caused by the Western diet

Breast cancer, colon cancer and prostate cancer are cancers that are related to the Western diet. But there are likely many other cancers that are also caused by it.

We know that free radicals cause cancer, such as from trans fats and rancid polyunsaturated fatty acids found in processed foods. Cancer is more common in obese people and people with diabetes.

Habits that make us eat more

There are habits that make us eat more like snacking and falling for so-called “fitness food” which contains dubious ingredients. It may come as a surprise, but married people can also fall prey to unhealthy habits together, forgetting about working out and sneaking in “skinny cocktails”. Read what Cynthia Sass, registered dietician had to say about this on CNN.

Solution to the Western diet

You may expect me to say that you should modify this or that in the Western diet. Modification does not work. You have to get radical here! The real solution is to abandon the Western diet altogether. Replace it with the Mediterranean diet without sugar and starchy foods. It is not that as bad as you can see from 1 week of recipes that my wife included in my book: “A survivor’s Guide To Successful Aging”.

You can eat cooked organic spinach, a piece of meat with slices of Avocado for breakfast. Cooking is done mostly with coconut oil or olive oil. Alternatively you may enjoy an egg or egg white vegetable omelette with lots of greens, mushrooms, onions and salsa and avocado on the side. Add to this caffeinated or decaffeinated coffee with stevia. Alternatively, a bowl of rolled oats, flaxseed and nuts with fresh fruit and organic milk, goat milk or yoghurt would make an excellent, sustaining breakfast. I am mentioning all of this to show you that you can get away from your familiar pancakes with maple syrup, sausages, waffles, toasts and muffins etc.

Food needs to be prepared form scratch with organic ingredients. GMO foods need to be avoided as the final judgment on these is decades away, and you do not want to become a human guinea pig.

Problems With The Western Diet

Problems With The Western Diet

Conclusion

The only way to “improve” a Western diet is to eliminate it and replace it by the Mediterranean diet. Throw all the processed food into the trash where it belongs! Avoid omega-6 fatty acids (polyunsaturated fatty acids), which have been shown to weaken the immune system and cause insulin resistance. The best fats are omega-3-fatty acids from marine oils (fish oil), coconut oil and olive oil. Forget all the other oils that are heavily advertised. They are not healthy.

I stick to organic foods although they are more expensive. Don’t forget that apart from a good diet you need to engage in a regular exercise program in order to prevent heart disease and cancer. And don’t stress out over the changes that you are about to make. Remember to manage your stress and relax!

References:

  1. Bruce Fife, C.N., N.D.: “The Coconut Oil Miracle”, 5th edition,2013, Penguin Books, NY 10014

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Aug
22
2015

Tools To Turn 100

By | alcohol, Alzheimer’s disease, Cardiovascular disease, Fitness, heart attack, Heart Disease, Mortality, Nutrition, Smoking, Stress management, Vitamins and supplements

A Swedish longevity study that went on for 50 years gave me the idea to blog about the factors that can help you to turn 100 and still have your mental capacity and good health. Let me introduce you to this study.

Researchers at the Sahlgrenska Academy in Göteborg, Sweden (which is the same as the University of Gothenburg) decided back in 1963 to follow a group of 855 Gothenburg men born in 1913 until they would either die or turn 100. The idea was to find out what killer diseases are in the way to reach such a ripe old age and if they would survive, what was it that made them to reach this age.

Think of it as a race to turn 100. The researchers had checkpoints along that journey: various surveys were conducted at the age of 54, 60, 65, 75, 80 and 100 to consider the factors that lead to longevity. 27% (232) of the original group reached the age of 80, and 13% (111) made it to 90. Only 1.1% of the men made it to the age of 100.

What were the causes of death for the other ones who did not make it? 42% of deaths after the age of 80 were due to heart attacks, 20% due to infectious diseases, 8% due to strokes, 8% due to cancer, 6% due to pneumonia and 16% due to other causes. 23% of the men over 80 were diagnosed with Alzheimer’s or dementia.

What else did the researchers find out? Factors that made people survive were refraining from smoking, maintaining a healthy cholesterol level and limiting coffee consumption to not more than 4 cups per day.

Another marker for longevity was either paying high rent for a condominium or own a house; in other words, a certain amount of wealth seems to be associated with longevity. Passing a fitness test at age 53 riding a bicycle was another peculiar finding of the study. This one points to the importance of fitness and clarity of thought as markers for longevity. There was a genetic factor also, as those who had a mother who lived to a ripe old age also survived longer than others who did not have this longevity advantage. However, researchers stressed that overall this genetic factor was of minor importance, the other factors that are under our control were much more important.

Two of the men who were 100 years old dropped out of the study: one because of dementia, the other one for personal reasons. Here are some of the facts about the other seven: none of them smoked; 2 lived at home, 5 in assisted living facilities. All of them wore hearing aids; all of them had good spatial and temporal cognition. All of them were slim, had good posture, but all used walkers to prevent falls or assist them walking. They were all able to read and watch TV, and most of them wore glasses.

Dr. Wilhelmsen who was part of the entire 50-year research effort said about the centenarians: “All of them were clinically healthy, satisfied with their circumstances and pleased to be living where they were.”

Other research about marriage, health and life expectancy

There is some peculiar research that found that men who are married are healthier than single men. This study came from the University College in London and was based on a group of 10,000 British people who were born within one week of each other on March 1958.

Being married or living common-law was beneficial for men compared to single men. One biomarker was the metabolic syndrome (a cluster of obesity, high blood pressure and diabetes), which was found to be 14% higher in non-married males while in females it did not matter whether they were married or not: they had the same low rate of metabolic syndrome. The longer men were married, the healthier they were. This was not so for the single male. Women, who married in their late twenties or early thirties, were much healthier in their later midlife compared to women who never married.

Harvard has published some interesting facts on men and marriage. A survey of 127,545 American adults showed that married men live longer than the unmarried males of the controls. A review of studies in the early 2000 suggested that when men were married to a well educated woman this may be causing heart attacks in the men. Quite peculiar, isn’t it? But this was refuted in a larger 2009 study, which found that married men live longer and are healthier when the partner is well educated.

Unhappiness and stress were singled out as a cause of high blood pressure, which leads to heart attacks later. Harvard reveals several other facts that are important with respect to longevity: cancer mortality is higher in unmarried men than in married ones; married men are at a lower risk of developing depression. They were found to have higher rates of satisfaction with life in retirement than their peers who never married. Marriage protects cognitive function and leads to a reduced risk of Alzheimer’s disease. Marriage is also associated with improved blood sugar levels and better outcomes with respect to cancer treatment or when hospitalized for other reasons.

General factors leading to longevity

We heard now several interesting points that seem to be linked to longevity. But what is it exactly that is behind some of these observations?

1. Diet

The Mediterranean diet is the gold standard as it has been shown to lead to the lowest mortality rates among diets.Note that longevity increases even more when sugar and starchy foods are avoided. And yes, a Mediterranean diet cuts down the risk for Alzheimer’s disease.

2. Exercise

It has been shown in many studies that regular exercise will reduce all diseases by about 50%! This is better than any medication; this is simply a must, if you are at all interested in living longer and healthier. Not only will your heart benefit from that, but your mind will thank you and not enter into dementia.          

3. Alcohol

This has been drummed to death, but the limit is 1 glass of red wine for women and 2 glasses of wine for men. Personally I do not believe that this is true. I have explained in a blog that the same heart protective effect can be achieved by 250 mg of resveratrol as supplement and avoiding alcohol altogether will prevent a number of cancers.

4. Smoking

Originally the Framingham Heart Study has shown that smoking is an important risk factor for heart attacks and strokes. Hundreds of other studies have verified this. Despite this fact women as a group are now repeating the experiment that has already been completed for men: smoking causes lung cancer and many other cancers as well as cardiovascular disease. I see young women thoughtlessly walking around town puffing their lives away.It shows you how powerful cigarette commercials are. Sometimes it is frustrating to watch this as a health care provider!

5. Stress management

This means seeking ways to reduce stress like meditation, self-hypnosis, yoga and others. This also means building social ties and mutually supportive relationships. It makes you feel that you belong, you have your place in society, you help others, and they support you.

6. Avoiding iatrogenic disease

Physician-caused illness is getting more common. Medications have become stronger and often have more potent side effects. For instance, if a physician treats a gluten-induced rash called dermatitis herpetiformis with a drug called Dapsone, the patient can get severe anemia, violent abdominal cramps and bloody diarrhea. A strict gluten-free diet would probably have helped the patient to clear up the rash. All of the symptoms that the patient had to suffer as a result of Dapsone were from this “iatrogenic disease”, which simply means they happened as a result of the doctor’s malpractice that had caused a medication-induced disease.

7. Avoiding exposure to free radicals

Many different agents like substances from pollution, radiation, rancid unsaturated oils and others contain free radicals that damage tissues and cause inflammation. Antioxidants like vitamin C, E and resveratrol can stop this as is reviewed here.

8. Using vitamins and supplements

As already indicated this will help to reduce free radical exposure by the use of antioxidants; reduce inflammation by using omega-3 fatty acids, Co-Q-10, vitamin C and E, resveratrol and others.

9. Avoid accidents

As you are aware, accidents can kill. Wear seat belts, drive safely, and stick to speed limits, particularly in curves. Also don’t drink and drive, don’t use your phone and don’t text and drive. The use of street drugs is also a common cause for accidents.

10. Use bioidentical hormone replacement

When we experience the change of life, called menopause in women and andropause in men we can allow nature to knock us off the planet or use scientific knowledge. It has been proven that it is perfectly safe not to use Big Pharma’s hormone concoctions that the body cannot recognize. Synthetic hormones cause iatrogenic disease as proven in the Women’s Health Initiative. Bioidentical hormones, however simply replace what is missing in menopause and andropause.

The reason this is important is that our system has hormone receptors on the surface of all body cells. In order to have normal function, we depend on bioidentical hormones to assist cell metabolism. For instance the heart muscle in a man has testosterone receptors as has his brain. In women estrogen receptors and progesterone receptors are contained in the cells. Using the right mix of bioidentical hormones based on saliva hormone tests or blood hormone tests can help the treating physician or naturopath to rebalance the body’s natural hormone needs with bioidentical hormone creams applied to the skin.

Tools To Turn 100

Tools To Turn 100

Conclusion

Tools to turn a hundred years old and still be fairly alert and fit are listed above. It is important that we start thinking along those lines, because it is only prevention that gets us safely there. If you allow yourself to constantly live it up and run your health down, how can you expect to turn 100? In the last 50 years the life expectancy has risen at least 20 years (85 years now, 65 years then). Now we are seeing a downward trend in the obesity and overweight population and the diabetics. They are the ones vulnerable to iatrogenic disease and mortality. They also are at a higher risk to die from heart attacks and strokes and they are more likely to get Alzheimer’s disease. Also, single men would do well to see their physician more often to check out their health status and perhaps change detrimental lifestyles that married men would not get into, because their wives talk to them. If you can switch from a curative approach in healthcare that usually does not work too well anyways to a preventative approach, you have a good chance to make it to 100. I talk to you then.

Aug
07
2015

Sugar As White Death

By | heart attack, Heart Disease, Inflammation, Nutrition, Prevention

We can think of sugar as white death, as sugar is responsible for heart attacks, strokes and even some cancers. Sugar is causing disability and mortality to a much higher degree than most people are aware of: a recent study pointed out that worldwide 184,000 deaths per year are attributable to sugar-sweetened beverage consumption; among those there are 133,000 deaths from diabetes, 45,000 deaths from cardiovascular disease and 6,450 deaths from cancers. Those people who developed disabilities from strokes, heart attacks, osteoporosis and severe arthritis measured 8.5 million disability-adjusted life years throughout the world and were related to sugar-sweetened beverages. 4.5% of these were from diabetes that was related to sugar-sweetened beverages.

These statistics are only regarding sugar-sweetened beverages! This does not take into account mortality from sugar in processed foods, in cookies, cakes and candies. It also does not take into account starchy foods like pasta, bread, bagels, white rice etc. that are all digested by amylase in the mouth and in the gut to turn into sugar within half an hour of ingesting them.

In the following I like to give an overview of what sugar does to our system.

History of sugar production

The initial production of refined sugar was developed in India as this review of the history of sugar shows.

In Great Britain the consumption of sugar was 4 pounds per person per year in 1700; it rose to 18 pounds per year in 1800, to 36 pounds per year by 1850 and over 100 pounds per year by the twentieth century. Similar figures are true for the US and in all developed countries. In 1747 the German chemist Andreas Marggraf identified sucrose in beet root. Since then technology was developed to extract sugar from the beet root, which was cheaper to do than extracting it from sugar cane. Both methods are in use today. In addition high-fructose corn syrup has been developed in 1970 and it replaces sugar in many uses, for instance in soft drinks and in processed foods.

Overall we are exposed to sugar in all disguises, such as sugar-sweetened beverages, candies, sweetened yogurt that is sold as “healthy”, power bars that are sugar laden and many more.

Effect of sugar on our bodies

1. Diabetes

As already pointed out above the average sugar consumption has increased from 4 pounds per person in 1700 to above 100 pounds per person in our time. Our poor pancreas has to cope with this additional burden of sugar and if it can’t, we get diabetes. The CDC says that in 2008 there were 8 cases of new type 2 diabetes cases per 1000 people in the US. The CDC projects that in 2050 this number will likely increase to 15 new cases of type 2 diabetes per 1000 people.

This shows you that the capacity of the human pancreas is limited. There is a breaking point regarding our insulin production. The insulin production has a limit, because the insulin producing cells in the pancreas can only produce a limited amount of this sugar-clearing hormone. When this point is reached the person is said to have developed diabetes. Diabetes causes heart attacks, strokes, kidney failure, blindness and circulation problems in the legs leading to amputations.

2. Cardiovascular disease

Diabetes is not the only problem that sugar causes. Our cardiovascular system is suffering because sugar makes the liver produce more LDL cholesterol that gets oxidized by sugar; the triglycerides are rising as well with continued sugar intake and with too much sugar intake there is excessive weight accumulation causing type 2 diabetes. This leads to more lipids in the arterial walls, called arteriosclerosis. The end results are heart attacks and strokes.

3. Cancer

It may not be obvious how sugar intake can lead to cancer. But sugar has been found to oxidize tissues and in the process produce dangerous free radicals. This causes chronic inflammation leading to mutations in the DNA of cells and weakening of the immune system. This will in time lead to cancer. Many cancer researchers have investigated this in detail in the last decades. I reviewed this in this blog, if you would like more information about it.

4. Brain atrophy and Alzheimer’s disease

Sugar overconsumption has been found to be one important factor in the development of Alzheimer’s disease, which is associated with the development of brain atrophy. Brain atrophy is just the mirror lesion in the brain that comes from hardening of the arteries. Brain atrophy develops when not enough nutrients and oxygen reach your brain cells. Part of the brain surface dies off and memory cells are lost. The end result is dementia or Alzheimer’s. Read more about this here.

5. Arthritis can come from sugar overconsumption

As I have summarized in this blog arthritis often is due to over consumption of processed foods including sugar products.

As I am explaining in this blog Dr. Hoffer has developed a simple supplementation for arthritis that will reverse the metabolic changes that are associated with arthritis. But you must switch to a Mediterranean diet without sugar and starchy foods, if you want to experience relief from your arthritis symptoms.

6. Low fat diet not helpful to reduce heart attack rates

As I pointed out before the low fat diet that was popular in the 1980’s until the early 2000’s did not help reducing heart attacks.

The low fat diet was laden with sugar, meaning that it was a low fat, high carb diet, and all of the problems I described above with weight gain, high LDL, high triglycerides and the development of diabetes caused more heart attacks and strokes. The real solution to preventing obesity and lowering heart attacks and strokes is to use a low carb/low to medium fat diet like the Mediterranean diet.

7. We need our muscles in older age

When we eat too many carbs from chocolate, candy, donuts and pasta there is not enough quality protein in our food to feed our muscles. If this is combined with a lack of exercise we are in double trouble of having flaccid muscles. This leads to falls and fractures, but is entirely preventable by eating a proper diet and exercising regularly.

8. ADHD can be fuelled by sugar

I have reviewed ADHD (attention deficit hyperactivity disorder) and mentioned that sugar and gluten sensitivity may be part of the problem. It is important to sort out nutritional factors by going through an elimination diet. Often our Western style diet (sugar and fat rich) is making things worse for the child with ADHD.

Apart from other measures avoiding sugar is very important for the ADHD patient.

9. Chronic inflammation

What causes chronic inflammation in the body and is responsible for both hardening of the arteries as well as arthritis? If you guessed sugar intake, you guessed right. I explained this in detail in this blog.

This concept is one of the biggest new things in the 21st century. The research goes back to the mid-nineties and culminated in the detection of an inflammatory marker, the C-reactive protein (CRP). The CRP level can now be used as a readily available blood test to detect inflammation in the body. Often this test will be positive in patients with arthritis, autoimmune diseases and cancer.

10. Obesity

Processed food contains wheat and sugar. The problem is that the high gliadin concentration in the Clearfield variety of wheat makes people addicted to food and sugar makes them gain weight. This is the cause of the obesity and diabetes wave. The remedy is to cut out all wheat and sugar as well as starchy foods. Switch to a Mediterranean diet without sugar and starchy foods.

11. Pimples and acne

Who would have thought that acne could come from a combination of sugar and milk products? Careful epidemiological studies have shown that in some regions of Africa, Brazil and Japan teenagers who eat the local food do not get acne, but when they switch to a Western style diet they come down with acne.

12. Tooth decay from too much sugar

Gum infections and severe tooth decay were found in the 1990’s to cause inflammation in the blood, which can be measured by using the C-reactive protein (CRP). Streptococcus viridans, a bacterium that populates gums and teeth can cause subacute endocarditis, a dangerous infectious disease of the heart valves, which can be responsible for sudden death in younger persons. There are other bacteria in the mouth that feed on sugar that we eat, particularly if we do not brush and floss our teeth regularly. This means there is double trouble: Sugar causes cavities and gum disease, but also causes heart attacks and heart valve infections.

Sugar As White Death

Sugar As White Death

Conclusion

Sugar and starchy food consumption affect so many organ systems that it is no wonder that people say that they feel better when they switch from the standard American diet to a Mediterranean type diet. We do not really want to buy a heart attack, a stroke, diabetes and Alzheimer’s disease when we go to the grocery store. But this is what you get in time when you buy the starchy foods and sugar containing processed foods that are in the center part of the grocery store.

The neighbor’s shopping cart

When I go shopping I always eye the groceries of my neighbor before or after me. Sometimes it is scary to look at the content of some of the shopping wagons. There is bread, potato chips, pretzels, chocolate bars, cookies, and the whole line-up that is really rich in sugar. Manufacturers mix sugar into healthy yoghurt, so it becomes unhealthy. Honey or maple syrup makes granola unhealthy. Jams contain 50% sugar, and on and on it goes. It is sobering to see how illness and disability is for sale, one shopping at a time. The reassuring truth is that you have choices!

Jul
18
2015

MIND Diet Helps Prevent Alzheimer’s

By | Alzheimer’s disease, Nutrition, Prevention

Researchers at the Rush University developed the MIND diet that helps prevent Alzheimer’s disease. MIND stands for “Mediterranean-DASH Intervention for Neurodegenerative Delay” and is a hybrid between the Mediterranean diet and the DASH diet that had been developed to help control high blood pressure.

The MIND diet was a prospective study where 923 people aged 58 to 98 years participated. Researchers followed these people for 4.5 years. Three groups of diets were tested: Mediterranean diet, DASH diet and MIND diet.

The MIND diet study result

The adherence to the diet was measured: those who stuck to the diet very closely, another section of participants that were less diligent, and finally one segment of people who did not take the entire thing too serious. With regard to the MIND diet the group with the highest adherence to the diet reduced the rate of Alzheimer’s by 53% compared to the lowest third. The second group still was able to reduce the rate of Alzheimer’s by 35%. The control diets were the DASH diet and the Mediterranean diet. The group that were strictly adhering to the DASH diet reduced Alzheimer’s by 39%, the group that were very conscientious in adhering to the Mediterranean diet reduced Alzheimer’s by 54%. The middle thirds of both control diets did not show any difference versus the lower thirds. The conclusion was that a strict Mediterranean diet has a very good Alzheimer prevention effect, as does a strict MIND diet. However, when patients do not adhere too well to a diet, the MIND diet is superior still yielding 35% of Alzheimer’s prevention after 4.5 years while the other diets when not adhered to that well showed no difference from being on a regular North American diet.

A brief summary of what Alzheimer’s disease is

A few years back the Pittsburgh PET scan was invented. It uses a Pittsburgh B compound radio-tracer to visualize the pathology in the Alzheimer’s brain. This research tool has made it possible to detect even the earliest Alzheimer’s disease (AD). The basic problem in Alzheimer’s patients is that there is brain atrophy, which can be more located in the front of the brain or in the back. There are two types of AD, the early onset AD (EOAD) and the late onset AD (LOAD). Using the Pittsburgh PET scan it was noted that the brain atrophy with EOAD is severe and located in the back of the brain; in contrast to that with LOAD, which is the more common form of AD the brain atrophy is located in the front of the brain. This imaging tool also allows quantitating the amyloid load; amyloid is a gooey substance that is produced by the inflammatory changes in the brain of Alzheimer’s patients (Ref.1). There are multiple possible causes why Alzheimer’s should develop in a person, but nothing conclusive has been determined. In February, 2015 I summarized a talk given by Dr. Smith at the 22nd Annual A4M Las Vegas Conference that also mentioned that there are many causes that can lead to Alzheimer’s disease.

The bottom line is that atrophy of the brain leads to loss of memory, personality loss and premature death.

The MIND diet

This diet was developed by Martha Clare Morris, Ph.D., a nutritional epidemiologist of Rush University in Chicago and her colleagues. The team observed that some foods were associated with a delay in the onset of Alzheimer’s disease while others contributed to an earlier onset of Alzheimer’s.

This is how they developed the term of the 10 “brain-healthy food groups” and the 5 unhealthy food groups.

Meet the 10 “brain-healthy food groups”: green leafy vegetables, other vegetables, berries, beans, nuts, poultry, olive oil, whole grains, fish and wine.

The 5 unhealthy food groups are: red meats, cheese, pastries and sweets, butter and stick margarine, fried or fast foods.

The 10 brain-healthy food groups are full of anti-oxidants, resveratrol and healthy fatty acids. They prevent hardening of the arteries and prevent the deposits of beta amyloid in the brain, which prevents Alzheimer’s disease. There is a bit of an issue about wine, which I have reviewed in this blog. You can replace wine with resveratrol extract as a supplement in order to get away from the toxic effect of alcohol, which is a cell poison. The choice is yours.

Why are the unhealthy foods unhealthy? There is too much trans fat in butter, cheese and margarine, which accelerate hardening of your arteries. The same problem exists with red meats, pastries and fried or fast foods. Sweets pose another problem: the sugar causes insulin levels in your blood to raise, which in turn causes inflammation in the support tissue of your brain, called glia cells, which secrete the beta amyloid that damages brain cells. At the same time sugar is metabolized by the liver into fat and triglycerides, which causes hardening of the arteries. The end result is earlier onset of Alzheimer’s.

According to Morris blueberries and strawberries, which are part of the brain-healthy food groups have been shown to be the most potent berries in terms of protecting against Alzheimer’s disease and preserving cognitive function.

With the late onset AD (=LOAD) that is the most common form of AD genetic factors hardly play a role. But what we eat will determine whether or not we get AD and we can postpone it significantly, if we eat mostly foods from the 10 brain-healthy food groups.

MIND Diet Helps Prevent Alzheimer’s

MIND Diet Helps Prevent Alzheimer’s

Conclusion

The MIND diet has been shown to be able to postpone the development of Alzheimer’s disease. It was developed based on the observation that some foods are good for us in terms of preserving cognitive function whereas others are bad. Knowing this it is advisable to eat mostly vegetables, poultry, fish, olive oil, nuts, beans, berries, whole grains, and some wine may be enjoyed as well. At the same time you need to avoid the bad foods mentioned above, like pastries, sweets, red meat, cheese and fast foods.

It is a small price to pay to keep your brain function until a ripe old age. The advantage with the MIND diet is that if you should occasionally deviate from the ideal, you still maintain a significant advantage over the DASH diet or the simple Mediterranean diet.

Reference:

1. Goldman’s Cecil Medicine, Twenty-Fourth Edition, Goldman, Lee, MD; chapter by David S. Knopman: Alzheimer’s Disease and Other Dementias, p. 2274-2283 Saunders 2012.

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Jul
11
2015

Experiments On Humans With New Statin Drugs?

By | heart attack, lifestyle, Nutrition, Stroke

This article is about experiments on humans with new statin drugs. The FDA released new statin drugs for use on a high-risk segment of the population with genetically high cholesterol. This has the name familial hypercholesterolemia and runs in families. There was a fast track for these drugs strictly to treat a high-risk population. There was a completion of smaller trials, but the the FDA expects the results of larger trials only for 2017. This leaves the uncomfortable question, whether physicians should prescribe these newer statins despite the lack of completion of proper trials.  In other words, are we doing experiments on humans with the new statin drugs, when the final word regarding their safety is not out.

Introduction

There was a news release about this story. There are a number of new super cholesterol lowering drugs. Physicians administer them by injection. They reduce the LDL cholesterol fraction. Oxidation of LDL is what causes hardening of the arteries very quickly. What made the news right now is Amgen’s drug, evolocumab and Sanofi and Regeneron Pharmaceuticals’ drug, alirocumab. The traditional thinking is that when you lower the bad LDL cholesterol you would save the patient from heart attacks and strokes. I have blogged about the cholesterol story and statins in November 2013 pointing out that statins can hurt the consumer. One concerning side effect of statin therapy is myopathy, a painful muscle disorder where statins have to be discontinued.

We need to be cautious about simplifying cholesterol blood results

Cholesterol is vital for cell function, for insulation of nerve fibers (myelin sheaths) and for synthesis of our steroid hormones (sex hormones and vitamin D3, now considered to be a hormone). The medical establishment took most of the information regarding heart attack and stroke prevention from the ongoing Framingham study. This clearly pointed to the importance of lowering the LDL cholesterol fraction (the “bad” cholesterol) and maintaining or increasing the HDL fraction (the “good” cholesterol).

LDL delivers cholesterol to vital organs

LDL cholesterol is actually an important cholesterol fraction that the body uses as transport molecule to all vital organs like the heart, the skeletal muscles and the brain to replace lipids in cell membranes. It is inappropriate to label LDL cholesterol as the “bad cholesterol”. This is an oversimplification.

The assumption in the recent past was that LDL requires a reduction to prevent heart attacks and strokes. But strictly concentrating on this could hurt patients because vital organs require enough nutrients to replace their cell membranes. Without cell membranes there is no life!

Some details about what causes heart attacks and strokes

I like to explain how heart attacks and strokes develop. At the center of the problem is how hardening of the arteries develops. In the 1990’s and in the next decade, from 2000 to 2010 detailed research into this has been completed. It has shown that free radicals have a lot to do with hardening of the arteries. There is not one single cause, but a combination of multiple factors that cause hardening of the arteries. One of the key facts is that people in civilized countries consume too much sugar and starchy food. The digestive process of the gut metabolizes starch into sugar, which the blood absorbs. In response to all this sugar the pancreas secretes an overload of insulin every day.

High insulin levels cause inflammation

The high insulin levels cause inflammation, which releases a number of aggressive molecules that attack the lining of the arteries. Sugar also oxidizes the LDL cholesterol and the HDL cholesterol, which makes the LDL cholesterol more aggressive as it now reacts like a free radical. Macrophages take up the oxidized LDL cholesterol; they turn into fat-laden foam cells, which in turn burrow themselves under the lining of the arteries. Normally the HDL cholesterol incorporates oxidized LDL cholesterol and brings this to the liver for further processing. However, sugar oxidizes HDL itself and it loses its protective function. The end result is that there is an acceleration of the hardening of the arteries and when this reaches a critical point, a heart attack or stroke can occur.

We need to rethink how to prevent heart attacks and strokes

What struck me with the FDA decision is that they seem to doggedly hold on to the hypothesis that heart attacks and strokes develop from LDL cholesterol that is too high. If this were the case, statins would have worked wonders in terms of preventing heart attacks and strokes, yet the number one killer is still hardening of the arteries. What I wrote in my blog in November 2013 is still true.

The solution to preventing heart attacks and strokes may not be attractive to some, but it is found in a proper diet and exercise.

These points are important

  1. We need to cut out sugar and starchy foods. This includes grains. Kellogg’s and cohorts won’t be happy nor will be your friendly baker or the bakery department in your supermarket.
  2. A Mediterranean diet is now the gold standard and adding olive oil and nuts to it will be even more effective in reducing mortality from heart attacks and strokes.
  3. Exercise has been proven to elevate HDL cholesterol significantly, so why not do less sitting and do more moving? When you cut out sugar and starchy foods, HDL is fully functioning and this keeps the LDL cholesterol honest. This means that only LDL without oxidation reaches the vital organs for membrane exchange work, while HDL removes LDL with oxidation like a sponge and inactivates it in the liver.

Misleading statin trials without diet changes

This is all: a three-point approach with no statins and no super statins. Big Pharma does not like this, but the three-point approach was proven to be effective for several years (Ref. 1, 2 and 3).

What I find particularly concerning is the fact that most of the super statin trials will only come out with the full results in 2017. We witness that the FDA has approved these new super statins to be used on the most vulnerable people (familial hypercholesterolemia) on top of regular statins. I fail to see how vital organs can function, if the diet is not changed.

CoQ-10 is essential as a co-factor

It also disturbs me that the average physician does not recommend CoQ-10 as a supplement to counter at least some of the side-effects of statins and super statins. There was no such recommendation. I feel that the FDA allows patients with familial hypercholesterolemia to be subjected to a human experiment of this nature. They are receiving drugs that we do not fully know yet. After 2017 we will know whether they have reduced heart attack and stroke rates or not.

Experiments On Humans With New Statin Drugs?

Experiments On Humans With New Statin Drugs?

Conclusion

I remember very well from the 1980’s what the suggestions were treating patients with high cholesterol. Cholesterol-lowering drug guidelines told practicing physicians to first assess the patient’s diet and exercise status. If modifying these lifestyle factors were ineffective, we would then only be using the statin drugs to lower cholesterol levels. In the meantime the scenario has changed and experienced a complete reversal in terms of diets. The high carb /low fat diet has been replaced with the low carb/medium fat Mediterranean diet, which by itself can be very effective in reducing LDL cholesterol. Recently research has shown that adding olive oil and nuts can lower mortality from heart attacks and strokes even more. It seems that the FDA is completely ignoring all this research.

History teaches us

I think that physicians and patients alike would do well to remember the following. It all started with the introduction of sugar, starchy foods and processed foods into the civilized world about 100 years ago. This caused an increase of heart attacks and strokes because of the processes explained above. The real solution is the 3-point program suggested above. This will likely solve 80% to 90% of all cases of hardening of the arteries causing strokes and heart attacks. Physicians treated the rest cautiously with cholesterol lowering drugs, like the statins; however, there is no room for human experiments.

More info on arteriosclerosis (hardening of arteries).

References

1. Dr. Steven Masley, MD: “The 30-day Heart Tune-Up – A Breakthrough Medical Plan to Prevent and Reverse Heart Disease”, Center Street, A Division of Hachette Book Group Inc. New York, Boston, Nashville, USA © 2014

2. David Perlmutter, MD: “Grain Brain. The Surprising Truth About Wheat, Carbs, And Sugar-Your Brain’s Silent Killers.” Little, Brown and Company, New York, 2013.

3. William Davis, MD: “Wheat Belly Cookbook. 150 Recipes to Help You Lose the Wheat, Lose the Weight, and Find Your Path Back to Health”. Harper Collins Publishers LTD., Toronto, Canada, 2012.

Jul
04
2015

Health Depends on Healthy Soil

By | Health, Nutrition, organic food

This write-up is about “health depends on healthy soil”. I never gave it much thought that soil quality should affect our health until I came across an article to that effect in the June Issue of the BC Medical Journal by Dr. Bill Mackie. It is entitled “Healthy soil, healthy population”. He makes the point that there is only a finite amount of fertile, arable land in British Columbia. The other areas are mountains where no food will grow.

In the past 5 years the Environmental Health Committee of BC (chairman Dr. Bill Mackie) has emphasized the importance of cutting back on the use of antibiotics in managing livestock as it causes resistant strains to enter the food chain and it also changes the bacterial composition of the soil. This damages the environment and it also makes antibiotics less effective in treating most of the bacterial infections.

Soil is a non-renewable resource

Dr. Mackie attended the 4th International Conference on Sustainability Science in France in September 2013. During the conference professor Daniel Nahon asked the question: “Why should we change agriculture?” He stated that apart from global warming that can affect the way crops are cultivated, the techniques of agriculture over the past 100 years have to be reviewed as they contribute to soil erosion, increased resistance of insects to chemicals and more frequent flooding.

Soil creation from continental crust rock to cropable soil takes a long time: to get 4 to 12 inches of bedrock transformed into cropland takes 20,000 to 30,000 years. So, effectively the soils that we encounter in our lifetime are a non-renewable resource.

Soil destruction

This means that we need government agencies to protect arable land. But this is not what is happening: The world’s reserve of cropland is 600 million hectares (=1482 million acres). What is destroying this land? It is soil destruction and soil sterilization. Erosion is the primary reason for soil destruction. This is mostly due to ploughing practices, forest clearing to build subdivisions as part of urbanization and herding associated with raising cattle. All these are responsible for shifting the balance towards soil destruction, which occurs 10 to 100 times faster than soil formation. Erosion rates are 10 tons per hectare (or 4 tons per acre) over 80% of Earth’s arable land.

With regard to urbanization keep in mind that in 1900 only 14% of the world population lived in cities. However, in 2000, 54% of the world population consisted of urban dwellers.

Soil erosion

Some more data: In the US 100 square meters (1076.3 square feet) are lost every second. China is losing 500 square meters (5381.5 square feet) every second. When you translate that into an easy to imagine figure, these two countries alone destroy the area of Denmark each year!

Dr. Mackie stated that when current trends of global food production are stacked against global population increases, we will reach a point in 3 centuries from now where the population will no longer be able to grow enough food to feed itself.

Preserving agricultural land

There are many unknowns though: This projection could be reached earlier, if there is more soil erosion than anticipated, but it could also be delayed by conservation practices. In British Columbia there has been a Provincial Land Commission since 2002 that developed strict agricultural zoning laws, called Agricultural Land Reserve (ALR). This makes it difficult for developers to build on valuable agricultural land, no matter how desirable this land would be from a real estate point of view. In BC this law has been instrumental in preserving agricultural land on the erosion side of the equation as mentioned above.

Health concerns

There are health concerns because of monoculture techniques that are employed on a large scale. With the monoculture practice artificial fertilizers have to be used to replenish the soil. But the plants are hardly extracting 50% of the fertilizers from the soil; the rest becomes part of agro pollution. Nitrogen and phosphorus are the main pollutants. A few years back some children consumed nitrate-contaminated water. Doctors diagnosed them as “blue baby syndrome”. Methemoglobinemia caused this condition. I could lead to brain damage or death. Now babies are fed formulas with water from reverse osmosis or bottled water. The Center for Disease Control also linked miscarriages to high nitrate levels in drinking water.

Over-fertilization

Another effect of over-fertilization is the leaching out of important minerals like calcium, magnesium and potassium. These minerals are then low in vegetables we eat and this affects our metabolism, as magnesium for instance is a co-factor in hundreds of enzymatic reactions in the body.

Concentrated animal feeding operations cause problems with regard to manure disposal. The farmers of these animals use heavy metals to promote growth and this results in high concentrations of arsenic, copper, selenium and zinc in the manure. This leaches into ground water and kills wildlife. But there are also antibiotic residues and resistant bugs in the manure of these concentrated animal feeding operations. In addition the animals carry superbugs, which can cause serious problems in humans.

Toxicity of food

With the monoculture techniques minerals and nutrients leached out of the soil and farmers used fertilizers, insecticides and Roundup weed killer to maintain the monocultures. This was good business for the chemical companies that produced all those substances, but has not been good for our health despite reassurances otherwise. The end result is that we humans have to deal with residues of insecticides in our food that function as estrogen-like substances causing cancer on the long-term.

Effects of Roundup and GMO crops

We also get exposed to Roundup that has been classified by the World Health Organization as “probably carcinogenic in humans” (category 2A carcinogenic).

Fertilizers are rich in heavy metals and have been found to cause cancer and methemoglobinemia.

Add to this the GMO issue that has not been resolved. Large manufacturers and those who are heavily invested in them are again pushing the envelope to the limit, but GMO crops are not harmless as some reports of infertility, breast cancer, malformations in newborns and autoimmune reactions in humans have shown.

GMO and “standard farming practices”

Scientists did not analyze GMO for GMO for toxic effects. Researchers tested GMO products on animals over a 3 month period. This will not do regarding safety in humans. It is sad that the GMO scientists in the US forced the population involuntarily in a long-term toxicity study.  Since the industry declared GMO in the US as “safe”, GMO food is now widely available in stores. In Europe governments were more cautious and did not allow GMO as freely. I prefer organic food, which is a certain protection from insecticides, fertilizers, Roundup and GMO.

The “standard farming practices” have insidious effects on our health and need to be reviewed by medical experts. One of the problems of starting new agroindustry practices was the fact that there was no input from consumers, from health professionals or scientists to look at how this would affect us as humans. The old-fashioned way of just doing something and waiting until there is a crisis does not work anymore in society today.

Discussion

Conservation agriculture employs three key principles that are worth mentioning:

1. Practice minimum mechanical soil disturbance, which is essential to maintaining minerals within the soil, stopping erosion, and preventing water loss.

2. Manage the topsoil to create a permanent organic soil cover; this allows for growth of organisms within the soil structure.

3. Adopt the practice of crop rotation with more than two species. This controls weeds and insects and cuts down the need for chemical sprays.

Recycling garden refuse is a good way to create natural fertilizer. The city of Kelowna, BC has developed the manufacturing of OgoGrow, which they call a “soil amendment”.

This is a mineral and organic compound rich soil that can be mixed with existing poor soil thus turning it into a higher quality soil.

Health Depends on Healthy Soil

Health Depends on Healthy Soil

Conclusion

With proper planning worldwide, programs like these work. Some form of agricultural land reserve legislation combined with soil enrichment with products similar to OgoGrow will slow down soil erosion.

Tampering with the food production of future generations is not an allowable option. We need more international conferences on sustainability science as mentioned above. But we also need activists in all countries looking out for our food quality.

At the present time the only alternative to eating tampered food is to buy organic food. Don’t allow chemical companies to mess with the quality of soil bacteria or food quality, don’t allow farmers to mess with antibiotics that contaminates your meat with superbugs. It is a multifaceted task that will involve worldwide co-operation.

Mankind depends on this kind of work to survive!

Reference

“Healthy soil, healthy population” by Bill Mackie, MD Chairman of Environmental Health Committee, BC/Canada BC Medical Journal Vol. 57, No.5, June 2015, page 201.

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