Dec
22
2018

Biological Age Is Different From The Chronological Age

Biological age is different from the chronological age said professor Morgan Levine from Yale Medical School. She is working in the department of pathology. She has found in her research that people of the same chronological age have very different biological ages. From a biological standpoint they may be much younger or older than their chronological age. When people are younger than their chronological age, they have less disease and less mortality. This article has reviewed the facts.

Measuring biological age

Dr. Levine also has developed tools how to determine the biological age. And when the biological age is higher than the chronological age, she recommends lifestyle changes that will set back the biological clock. We age differently according to what we eat, how our genetic make-up is, which we cannot change, whether we are physically active and what environmental toxins we are exposed to. So, the biological age determines our health status and what our final life expectancy will be.

Biomarkers for biological age

A simple blood test that your family doctor can order consists of the following. A fasting blood sugar, kidney and liver tests, immune tests and inflammatory tests. In addition the doctor will want to know whether you are smoking or not, how much alcohol you consume and how much red meat and processed meat you eat. A computer program processes these results, which determines your biological age.

Lifestyle improvements can lower biological age

Biological age testing has a strength built in. By changing your lifestyle you can lower it. When you exercise more regularly and switch to eating a Mediterranean diet you can lower your biological age. Other studies have shown that the Mediterranean diet is anti-inflammatory. A telomere test, which also determines the biological age, is fixed. It is not easily changed by dietary measures and increasing your exercise.

Dr. Levine said: “I think the most exciting thing about this research is that these things aren’t set in stone.”

Putting the biological age to the test

Dr. Levine was curious what her own biological age was. She entered her blood test data and lifestyle facts into the computer. She was surprised that her biological age was not as good as her first assumption. Now she is trying to get more sleep, has increased her exercise level and improved her diet.

Her research team is working on getting the algorithm online so that everyone will be able to put one’s blood tests and other data into the computer program and calculate the biological age. The program will also recommend what steps are likely most helpful to increase one’s health and decrease the biological age.

Lower your biological age

No one wants to live a long life, if they are in pain and have various illnesses like arthritis or Alzheimer’s. But things are different, if they can change lifestyle factors and maintain a low biological age for a long time. Now they can stay active, have no pains and are able to contribute to society.

“By delaying the onset of diseases and cognitive and physical functioning problems people can still be engaged in society,” Dr. Levine said. “I think that is the ideal we should be striving for.”

Other literature about biological age

Inflammation increases the biological age

In this publication the authors stressed that inflammation is the common denominator for developing disease and premature aging. The authors stress further that it is mandatory to change one’s lifestyle to lower the biological age and live longer.

Diastolic blood pressure predicts mortality

In an older study the diastolic blood pressure was related to mortality. The higher the diastolic blood pressure was, the higher the mortality.  The authors also noted that it was the persons with the higher biological age who were at the highest risk of dying.

Scientific study about the predictors for the biological age

Here is a scientific study that examines predictors for the biological age.  This is not easy reading, but I placed it here for completeness sake.

Link to a site that can calculate your biological age

Here is a link to a site that calculates your biological age. It is probably not as good as Dr. Levine’s computer analysis will be when it is available. However, it is a good approximation to what it will be like.

Biological Age Is Different From The Chronological Age

Biological Age Is Different From The Chronological Age

Conclusion

The dream of staying younger for longer is not new. Research has shown that we actually can do something about it. If we look after our lifestyle, don’t smoke, don’t drink excessively, eat a sensible Mediterranean-type diet and exercise regularly, our biological age will be less than our chronological age. It is the biological age that determines how old we get and whether or not we will suffer from age-related illnesses. Researchers also found out that when your biological age is younger than your actual age mortality will occur later. The math is simple. Let’s assume that your biological age is 15 to 20 years younger than your chronological age. As the average life expectancy presently is 80 years, your life expectancy can increase to 95 or 100 years.

Dec
16
2018

Can Longevity Research Make Us Age Slower?

Longevity research has done a lot of experiments, but can longevity research make us age slower?

This year an 800-page summary was published of all the longevity research that has been going on. A review of this research is in this abbreviated article.

The entire report can be found here.

In the following I like to address some of the problems of anti-aging or longevity research.

Telomere lengthening

We know that people with longer telomeres live longer than people with short telomeres. When telomeres are longer, the cells can continue to divide and function normally. When telomeres shorten there comes a point when no more cell division is possible.  At this point the cell will normally be dissolved. When it persists, there is the danger that it undergoes a malignant transformation. This can cause premature deaths. On the other hand, if enough shortened telomeres accumulate in various organs, organ failure ensues. This will also result in premature deaths.

Research in humans has shown that increased physical activity elongate telomeres. So do vitamin C, E, vitamin D3 supplementation and resveratrol. A Mediterranean diet and marine omega-3 fatty acid supplementation elongate telomeres as well. In addition higher fiber intake, bioidentical estrogen in women and testosterone replacement in men can be effective in elongating telomeres. Finally, relaxation techniques like yoga and meditation are also elongating telomeres.

Antioxidants

Many processes lead to free radicals. Free radicals are unstable atoms that may damage cells and can cause illness and premature aging. Inflammation, the metabolism of our mitochondria, radiation exposure, industrial solvents and ozone are just some examples of what can cause free radicals in our system. If we have enough antioxidants on board, there is a balance between free radicals and antioxidants. No damage would occur then. In humans the two major antioxidants present are vitamin C and glutathione. Vitamin C comes from our food. Glutathione is produced by the liver and circulates in the blood. These two antioxidants are keeping free radicals in balance.

 

Anti-inflammatories

This Harvard site explains that even food can cause inflammation in us. For instance sugar, French fries, red meat and margarine cause free radicals. Anti-inflammatory foods are tomatoes, green leafy vegetables, olive oil, nuts, fatty fish, berries and fruit. A Mediterranean diet has anti-inflammatory qualities. There are 6 anti-inflammatory supplements that are useful to know about: ginger, fish oil, alpha-lipoic acid, curcumin, resveratrol and spirulina. In addition to the above, vitamin D3 also has anti-inflammatory effects in higher doses.

Chronic inflammation can cause cancer down the road, so it is important to prevent this by eating sufficient amounts of anti-inflammatory foods and supplements.

Genetic repairs

Spontaneous mutations of DNA, mutations of suppressor genes, oncogene activation and insufficient DNA damage response can all lead to cancer. In the past there was the hope of using chemotherapy and radiation therapy as a means to influence the outcome of cancer treatment. A reinvestigation of this concept is ongoing.

More specific treatment modalities are under investigation. When more cancer can be prevented and when it is possible to cure more cancers longevity in the population will increase. Cancer has been one of the major killers over the years.

Metformin research

Metformin has been in use for decades to prevent and treat diabetes. But beyond this it also has anti-cancer activity, it prevents Alzheimer’s, prevents cardiovascular disease and may be the first anti-aging drug. A trial to this effect is ongoing.

It makes sense that a drug that treats and prevents diabetes would be a longevity drug at the same time. The fact that it also helps to prevent cardiovascular disease and Alzheimer’s disease also makes sense. Anytime you remove a chronic disease, life expectancy improves. As a result metformin will likely receive approval as a longevity drug soon.

Mitochondrial repair

The mitochondria are small organelles in each cell. The purpose of this structure is to provide energy. In normal cells there are hundred of these organelles in each cell. In heart muscle cells, brain cells and liver cells there are thousands of mitochondria in each cell to provide energy. Muscles, nerve cells and liver cells require more energy to function properly.

Two supplements have been in use for some time to support mitochondria function.

  1. Co-Q10. This supplement supports mitochondrial function. It prevents heart disease, together with vit. K2 and vitamin D3 and it keeps blood vessels open.
  2. Pyrroloquinoline Quinone (PQQ). This supplement can increase the number of mitochondria in a cell. It can also improve their functioning. With aging we know that we are slowly losing mitochondria. It is important to know that there is a supplement that can counter the aging effect and prevent further mitochondrial loss.
Can Longevity Research Make Us Age Slower?

Can Longevity Research Make Us Age Slower?

Conclusion

For centuries people were hoping to live longer. Nowadays this dream seems to become a reality. But it does not happen with one magic pill. The aging process involves multiple targets that need attention. The telomere length is one factor. I listed a number of items that will elongate telomeres, like regular exercise and a Mediterranean diet. Antioxidants and anti-inflammatories are prolonging life as well. You want to preserve the function of your genes. Research is concentrating on improving gene repair.

Metformin has been found to prolong life. This molecule might be the first longevity drug. It has been in use to prevent and treat diabetes, but it also helps to prevent cardiovascular disease and Alzheimer’s disease. Two supplements help with mitochondrial repair, namely Co-Q10 and PQQ. Because life is all about energy, it is important to have well functioning mitochondria in all of your cells. When mitochondria are functioning, your body functions at its best, and you feel well.

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Nov
26
2018

Gut Bacteria Crucial To Healthy Aging

New research presented at the London Microbiome Meeting asked the question “are gut bacteria crucial to healthy aging?” Marina Ezcurra, is a Ph.D. is a researcher working at the Queen Mary University of London in the United Kingdom. She uses a nematode (round worm) model to investigate various aspects of aging. Nematodes like C. elegans provide a useful model not only for genetic work, but also for the human gut flora as well. Moreover, it allows making observations about the connection between bacterial genes and aging. Coupled with the fact that the worm has such a short lifespan, the researchers can test bacterial genes, the aging of the worm and get meaningful results in short order.

It seems like one of the research objectives was changing the nematode’s gut flora and observing life expectancy and age-related diseases.

Pathological versus healthy gut bacteria composition

Dr. Ezcurra did a couple of experiments with the nematode C. elegans as a model. She could show that the worm’s gut bacteria composition mattered. First of all, if there was a pathological composition of the gut flora, the worm did not turn as old and there were various age-related diseases that developed. Secondly, they were very comparable to human age-related degenerative diseases like Alzheimer’s disease.

Another senior author researched how genes of gut bacteria influence life expectancy

Meet Dr. Meng Wang, associate professor of molecular and human genetics, Baylor College of Medicine in Houston, TX. He did extensive genetic research on C. elegans. He used this model, because C. elegance lives only 2 to 3 weeks. This animal model is easy to manipulate. For instance, he studied the gut bacteria composition. This link explains that he tested about 4000 E.coli bacteria with various gene defects. 29 E.coli strains when deleted, increased the worms’ lifespan.12 bacterial mutants among those prevented cancer and amyloid-beta, found in Alzheimer’s disease. Some mutant bacteria caused longevity by acting on processes linked to aging.

Colanic acid is an important anti-aging factor in C.elegans

Dr. Wang joined Dr. Christophe Herman, associate professor of molecular and human genetics at Baylor, for further research. It turned out that one of the keys to longevity of the nematodes were the mutant bacteria in the gut over-producing the polysaccharide colanic acid. This allowed the nematodes to live much longer. The researchers could show further that fission and fusion processes with regard to mitochondria are important. Mitochondria are the energy packages in cells and these processes are regulated by the presence of colanic acid. As a result, if your gut has good bacteria you can grow old and escape Alzheimer’s disease and cancer.

Dr. Meng Wang said: “Of the nearly 4,000 bacterial genes we tested, 29, when deleted, increased the worms’ lifespan. Twelve of these bacterial mutants also protected the worms from tumor growth and accumulation of amyloid-beta, a characteristic of Alzheimer’s disease in humans.” 

Creating longevity with metformin, a diabetic drug

Physicians have known for some time that metformin stimulates longevity genes. This is the reason why diabetics on metformin live longer than diabetics on insulin. Dr. Ezcurra mentioned on 24 October, 2018 in her talk at the London microbiome Meeting that she had done experiments with C. elegans and metformin. Metformin reduces the risk of cancer and increases longevity in C. elegans as well as in mice (other experiments). Currently there is a clinical trial going on that investigates anti-aging under the influence of metformin in older people.

Effects of metformin on anti-aging

Metformin has the potential to target diabetes, cancer and Alzheimer’s pathologies all at once.

The anti-aging effect in humans with metformin involves the gut bacteria. Dr. Ezcurra says that this is the reason why diabetics on metformin live longer than diabetics on insulin. Metformin influences the folate bacterial metabolism of the gut flora. Other research has shown that the Akkermansia bacteria in the gut, which are good, desirable bacteria, will increase from 3-5% to 12.44% of the gut flora under the influence of metformin. Here is the discussion in detail in the following link.

Effect of gut bacteria on psychiatric diseases, obesity and diabetes

Dr. Ezcurra said that there are many studies showing that dysbiosis of the gut can lead to psychiatric diseases, Parkinson’s disease, obesity and diabetes etc.

We need to know more about whether a healthy gut flora will let us age without causing age-related diseases. Dr. Ezcurra stated: “By better understanding the links between nutrition, microbiome, and health, we can understand how the elderly can maintain their microbiome, and also help them directly by using pre- and probiotic strategies. This would help us age in a better way, maintaining health and quality of life in old age without drugs or surgery.”

Gut Bacteria Crucial To Healthy Aging

Gut Bacteria Crucial To Healthy Aging

Conclusion

The composition of the gut microbiome appears to determine whether we age gracefully or not and whether we get sick as we age or not. Everything depends on the diversity of the gut flora. There are bacteria in the gut that are good for us and also bacteria that are bad for us. Metformin has been shown to stimulate the good gut bacteria to multiply. Dr. Ezcurra is continuing her research into this. She clearly stated that it should be possible for us to age in a better way and maintain health and quality of life in old age without drugs or surgery.

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Oct
27
2018

Four Diseases Cause Most Of The Deaths

Four diseases cause most of the deaths around the world: cancer, cardiovascular disease, chronic respiratory diseases and diabetes. This story is the news right now. 50% of the 193 UN member states that signed a treaty in 2015 are falling short of their promise. They wanted to reduce premature deaths from these diseases by 2030. But this is not happening as this story shows.

I like to review these 4 key diseases and what we can do ourselves about eliminating them. We cannot afford to wait for things to happen on a national level. Rather we need to go to the grass roots of every country and change the risk factors that cause these 4 diseases.

Cancer

First, cancer is a disease of older people, unless strong genetic factors are present. In this case even children can get leukemia, brain tumors and osteogenic sarcoma. In older people DNA mutations and DNA breaks happen more often as we age. On the other hand, if we diagnose cancer in stage 1 or 2 (in the early stages), it is quite often curable.

Oncoblot test, a cancer screening test

Probably one of the less known new criteria is the fact that there is a very sensitive cancer blood test, called the Oncoblot test (released about 4 years ago by the FDA). The latest screening test that came out of the human genome project is called the Oncoblot test. It screens for 25 of the most common cancers. And it is screening for ENOX2 proteins from cancer cells. It is a 1000 USD test in the US that health plans will not cover, but it will screen for more than 25 different common cancers 6 to 8 years before they would otherwise become clinically manifest.

If you discover cancer with this early blood test and you treat it right away, you have a good chance to live a few years longer. You may come down with another cancer down the road, but treat it early again, and you will still have a better life expectancy. Remember: four diseases cause most of the deaths, cancer is one of them!

Cardiovascular disease

Furthermore, people develop cardiovascular disease from poor eating habits and a lack of regular exercise. There are a few percentage points of people with familiar high cholesterol. These people need to see their family doctor for a prescription to lower cholesterol. But the majority of people will do well by changing their diet into a Mediterranean diet; lose weight until their body mass index reaches a value of 21 to 24. With this diet it is important to cut out all refined sugar and starchy foods. Regular exercise in a gym will also prevent hardening of the arteries. Chelation therapy has been shown in this study to help reduce hardening of arteries.

Diabetes patients have accelerated hardening of the arteries

We know from diabetic patients who have accelerated hardening of the arteries how devastating cardiovascular disease can be. Heart attacks, strokes, kidney failure, amputations of the lower leg and blindness are just some examples. Even patients who do not have diabetes can get these complications at an older age. The key is to think preventatively, change the diet, exercise regularly and you will lower all those risks. Remember: four diseases cause most of the deaths; cardiovascular diseases belong to that group and are a major player.

Chronic respiratory diseases

There are different reasons why a person may develop chronic respiratory disease. A common disease is chronic obstructive pulmonary disease (COPD). COPD often has a link to smoking heavily as a younger person. This is where the damage to the lung tissue has started. Exposure to cigarette smoke leads to loss of elastic tissue in the bronchial tubes. The lungs have a difficult time to exhale to get rid of the CO2. The end result is that your breaths are shallow and you can’t get enough oxygen, because the lung is already filled with air.

Asthma and COPD

Another disease is asthma. Nowadays physicians can treat this condition well with a corticosteroid inhaler and salbutamol. Salbutamol dilates the airways by relaxing the muscles of the bronchial tubes. The corticosteroid keeps the lining of the bronchial tubes thin, so that the air can move in and out of the lung.

If asthma is not treated properly there can be permanent damage to the airways and the clinical picture would look similar to COPD.

With end-stage COPD patients the only therapy the physician can offer is continuous oxygen flow treatment. With power failures these machines that supply oxygen will stop working. People need to make provisions to have a back-up generator. Again, we need to remember: four diseases cause most of the deaths. Chronic respiratory diseases belong to them.

Diabetes

Patients with type-2 diabetes (Type 2 DM) are usually older than 30 years of age.

That’s why they are called “mature onset diabetes” or “adult onset diabetes”. For several decades a patient may “incubate” diabetes and have one or more of the diabetes risk factors, such as high blood pressure, obesity, high cholesterol or high triglycerides, but have normal blood sugars.

Physicians have followed patients like this for several decades in the well known Framingham Heart Study and found that a high percentage of them do come down with type-2 diabetes later in life. In the past this time of incubation was termed “pre-diabetes”. Now we call it “syndrome of insulin resistance” or “metabolic syndrome”. Diabetes belongs to the group of diseases that are associated with chronic inflammation in the body.

Causes of type-2 diabetes

Type-2 diabetes often associates with other endocrinological diseases such as Cushing’s syndrome (an adrenal gland hyperactivity) or acromegaly (increased growth hormone production). In these diseases other hormones are tilting the hormone balance by counteracting insulin thus leading to a relative shortfall of insulin, which is another cause for type-2 diabetes. There is confusion among scientists regarding possible genetic reasons for type-2 diabetes. The environment or weight gain may trigger various genetic loci that exist. The syndrome of insulin resistance has shown some connections between hypertension, obesity and type-2 diabetes.

Death in diabetics usually comes from a heart attack, a massive stroke, but it may also come from systemic infections, called sepsis. Dr. Taylor from Newcastle University showed on 30 volunteers that 43% of diabetics could be cured by a diet of 600-700 calories for 8 weeks. The medical literature also knows that regular exercise is beneficial for diabetics. It cannot be overstressed that four diseases cause most of the deaths; diabetes belongs to them and is a major player.

Four Diseases Cause Most Of The Deaths

Four Diseases Cause Most Of The Deaths

Conclusion

Four diseases cause most of the deaths. They were the cause of death for several years. They are cancer, cardiovascular disease, chronic respiratory diseases and diabetes. The secret is to minimize the impact of each of these diseases. You can prevent chronic respiratory diseases by stopping to smoke and treating asthma properly. To treat cancer successfully one needs to diagnose it early and remove it surgically. With cardiovascular disease chelation therapy has shown a difference. Otherwise a regular exercise program and a Mediterranean diet, which has anti-inflammatory qualities, will help. Dr. Taylor from Newcastle University demonstrated that he can treat diabetes with a low calorie diet. Each one of us has a responsibility to do something about our diagnosed condition. We cannot wait for magic cures. We need to do what has known benefits. Hopefully with these short hints will help you to improve your health.

Sep
15
2018

Moderate Carb Intake Has The Lowest Mortality

A 25-year long study has shown that a moderate carb intake has the lowest mortality. A comprehensive study from the US has followed more than 15,000 men and women for 25 years. They were between 45-64 years when they entered the study and they were from diverse socioeconomic backgrounds. The authors chose mortality as an end point. Dr. Sara Seidelmann is a clinical and research fellow in cardiovascular medicine from Brigham and Women’s Hospital in Boston. She was the lead author of this study. The research group used food questionnaires and analyzed the carb content in the food. They also determined what percentage of the food composition was of animal origin or plant origin.

Research study finds moderate carb intake has the lowest mortality

The main findings of the study were that less than 40% of carbs in the diet led to an increased death rate with a mortality of between 1.4-fold and 1.8-fold. On the other hand, more than 70% of carbs in the diet also had increased mortality rates of 1.2-fold. The lowest mortality was in the group that consumed a diet where carbs were between 50% and 55%. Dr. Seidelmann explained that in terms of life expectancy the result of the study could be summarized as follows. A 50-year-old person had another 33 years to live when carb intake was in the moderate range. The low-carb person had only another 29 years to live (4 years less than the moderate carb person). The high-carb person lived another 32 years, 1 year less than the moderate carb person.

Plant-derived versus animal-derived fat and protein

The study showed that there was increased longevity when carbohydrates were exchanged for proteins and fats from plant sources. Mortality was 18% less for this group. Conversely, when carbs were replaced for animal-derived fat or protein mortality was 18% more!

Dr. Seidelmann noted that this study was coming from a US based population. In the case of an Asian group they would consume much more carbs on average, but they would replace a lot of the animal fat and protein with fish. Fish is a healthier source of protein and fat than beef or pork.

A moderate carb intake group that used protein and fat from animal sources was compared to plant sources. When protein and fat had the origin from lamb, beef, pork, and chicken the mortality over 25 years was higher. When protein and fat came from vegetables, such as nuts, peanut butter, seeds and whole-grain breads there was a lower mortality rate.

Other studies comparing the effect of animal protein versus plant protein

  1. A 2016 study that had gone on for 49 years was involving 131,342 participants. Animal protein intake showed an association with higher mortality from heart attacks and strokes. 3% of energy from processed red meat was now substituted by an equivalent amount of plant protein. This reduced the all-cause mortality by 34%, for unprocessed red meat by 12% and for egg by 19%.

 

  1. Red meat is cancer-producing. Several studies have shown this. When red meat is digested, cancer-causing substances are released that can be the cause of cancer in the lining of the stomach and the colon. The above link says we should limit red meat consumption to 65 grams (2oz.) per day or 2 servings (130 grams or 4 oz.) 3 to 4 times per week. We should avoid eating more than 455 grams (1 pound) of lean red meat per week.

Triglycerides are an independent risk factor for heart attacks

In this publication evidence is also present that triglycerides are an independent risk factor that can cause heart attacks.

When you eat too many carbs, the body produces the excess you don’t need into triglycerides, and it deposits its subsequently as fat in fatty tissue.  Physical activity burns up some of the triglycerides. But when we eat too much refined sugar and starchy foods, there will be an excess of triglycerides putting our blood vessels and our hearts at risk.

Regular exercise prevents disease and premature deaths

Many studies have shown that regular exercise prevents heart attacks and premature deaths. We even know the mechanism of why this is so. Exercise releases nitric oxide ((NO) from our blood vessels, which widens the arteries. This also prevents high blood pressure. Exercise elevates the protective HDL cholesterol. When regular exercisers were compared to a non-active group they had a 41% lower risk of death. All-cause hospitalizations were down by 21% and cardiac hospitalizations were down 32%.

Discussion

  1. Barry Sears is the inventor of the Zone Diet. I attended a lecture in 2001 at an Anti-Aging Conference in San Diego. Dr. Sears was the keynote speaker at this conference. He stressed that a diet with 55% of complex carbs would be the best diet. It is interesting that Dr. Seidelmann in the study mentioned in beginning of this blog found the same thing. The lowest mortality was in the group that consumed a diet where carbs were between 50% and 55%.
  2. The second point that is important to note is that it matters whether we eat protein derived from animals or from plants. Even small steps help. When we reduce our animal protein intake by only 3% of the energy intake, and replace it by plant protein, there is a significant reduction in mortality.
  3. Exercise is rarely mentioned in relation to diets. But exercise needs to be included every day and you will experience a reduction of cardiac hospitalizations of 32% as mentioned above.
Moderate Carb Intake Has The Lowest Mortality

Moderate Carb Intake Has The Lowest Mortality

Conclusion

A moderate carb intake, as is the case in the Mediterranean diet and in the Zone Diet of Barry Sears, has the lowest mortality rate. Complex carbs (in vegetables) are absorbed much slower. As a result the risk for heart attacks is much lower. The opposite is true for refined carbs from sugar. They cause heart attacks and strokes with premature mortality. Dr. Sara Seidelmann led a study at the Brigham and Women’s Hospital in Boston that lasted 25 years. Less than 40% of carbs in the diet led to an increased death rate with a mortality of between 1.4-fold and 1.8-fold. These diets are paleo-type diets, the Atkins diet and the ketogenic diet. More than 70% of carbs in the diet also had increased mortality rates of 1.2-fold.

The healthiest diet

People who consumed a diet where carbs were between 50% and 55% had the lowest mortality rate (Zone Diet). Another finding of this study, which was confirmed by others is that animal-based protein is unhealthier than plant-based protein. Even replacing 3% of energy from an animal-based diet with plant-derived protein delayed mortality significantly.

If you want to live longer and stay healthy you need to critically evaluate what you eat.

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Jun
16
2018

Writing A Medical Book

In my 40’s when I was practicing medicine, I was dreaming about writing a medical book. This was in the mid 1980’s and I was busy seeing 30 to 40 patients a day. I would never have found the time to write a medical book at that time. I thought, perhaps I could show how patients could stay younger for longer by adopting the right life style in order to stay well. Fast forward 3 decades, and the medical book writing began. But instead of one book the project turned into 4 books. There were too many topics to cover to fit them all in one book.

Prior to writing a medical book

First of all, in 2002 I published a large website. Its structure is like a book on the Internet: Net Health Book . It contains descriptions of the major diseases, mental and physical, and their current treatment modalities. I still maintain this work. Furthermore, I started another website in 2003, a weekly blog, called “Ask Dr. Ray” . This is a compilation of interesting research. Some medical research papers can get too scientific. For this reason I translated it into easier language. The topics tend to be anti-aging topics. This blog comes out Saturdays.

Retirement hobby

When I retired in 2010 I revamped my websites. In the process the web developer suggested I should add to Net Health Book a blog (nethealthbook.com/news) where I review current health news that I find interesting. This is a weekly blog, which I publish on Wednesdays. All of this is still going on, and it gave me lots of opportunities to write and publish on a smaller scale. In addition, I finally started publishing books.

A Survivor’s Guide To Successful Aging

My first book came out with Amazon in 2014. I had joined the A4M (American Academy of Anti-Aging Medicine) in the early 2000’s. The lectures at their conferences were very open-minded and pointed out details of what one could do to delay aging and avoid premature deaths. My own experience with changing our diet in 2001, starting bioidentical hormone replacement and changing my lifestyle became topics that were part of this book. I dedicated this book “to those who are willing to work on prevention in order to achieve a longer life without disabilities”. This is still the basis of prolonging your life.

Lifestyles can be deleterious

I start out in this book describing the obesity wave and how this changes the metabolism (metabolic syndrome). I used statistics from the Framingham Heart Study to show the detrimental effects of various lifestyles on mortality. Subsequent chapters deal with food, exercise, stress and missing hormones as life-shortening factors. There is a separate chapter on vitamins and supplements. They as a group can create 5.1% longer telomeres, which translated into 9.8 years of longer life expectancy (see also a study by Dr. Xu  in the book). Subsequently it describes how a change of your lifestyle can have a positive impact. Changing your eating habits and exercise activity will make a tremendous positive difference on the long term.

Successful Aging in the Kitchen

The book ends with an appendix, written by my wife: “Successful Aging in the Kitchen”. You are presented with recipes for 7 breakfasts, 7 lunches and 7 dinners. In addition she has provided 7 healthy desserts for you. Bon Appétit!

Healing Gone Wrong, Healing Done Right

In another book, which got appeared in 2016 I gave a few examples of how famous people were failed by medicine. It started already in the past: Ludwig van Beethoven’s physicians did harm instead of healing their patient. However, this is happening now as well: physicians mismanaged the health care of Elvis Presley, Churchill, Michael Jackson and JF Kennedy. The physicians treated symptoms, but they never properly attended to the causes of the ailments of their patients. The end result was premature death in all of them. Churchill who had good genetics made it to age 90, but during his last 15 years he suffered of severe disabilities.

Treatment of symptoms will fail, treatment of causes succeed

These examples of famous people’s health problems resemble to what happens to today’s patients in various office settings. Their symptoms are mostly being treated, but their causes often not. Simply treating symptoms will not work on the long term. It did not work in the past, and it does not work now.

Other chapters in this book

Other chapters in this book deal with preventing disease, keeping a healthy brain and keeping a healthy heart. Next I discuss why food matters, followed by the health of limbs and joints. Subsequently I am discussing how to keep toxins out. The next chapter deals with how to reduce the impact of cancer. It is always important to diagnose cancer as early as possible as removal by surgery has the highest success rate at an early cancer stage. The next chapter is entitled: “Stable hormones key to health”. If any of your hormones are missing (particularly around the age of menopause and/or andropause) it is time for nature identical hormone replacement. The next chapter gives you general thoughts on anti-aging. This is followed by “supplements yes, but do not overdo it”.

Alternative treatment for ADHD

A final chapter gives you an example of an alternative treatment for ADHD, where the idea of not just treating symptomatically, but treating causes is included. References and an index are also provided for the book.

Prostate Cancer Unmasked

Furthermore, I did not intend to write this book. But in early 2016 my PSA (prostate specific antigen) level jumped from 3 to 8.6. For years it had been in the 1.5 areas, then slowly increased to 3. But 8.6 was too high for comfort! I had an MRI scan done, which showed one lesion in my left prostate, which was suspicious for prostate cancer. I was referred to a urologist at the Vancouver Prostate Centre, one of the top clinics in Canada. But I had already researched the literature and came across research by Dr. Gary Onik from Ft. Lauderdale who warned me about the pitfalls of “standard therapy”.

The conservative urologist in Vancouver

The urologist in Vancouver told me that without a positive biopsy he cannot accept that the shadow on my MRI scan would be prostate cancer. And the only way they do a prostate biopsy was by random trans-rectal biopsies. He also wanted to include me in a random clinical trial where they would compare active intervention with active surveillance. I politely declined the trans-rectal prostate biopsy and the inclusion into a trial.

Assessment by Dr. Onik

I booked a flight to see Dr. Onik in Ft. Lauderdale. His method is well researched and orchestrated.

Initial assessment

He assesses you with a rectal ultrasound and he sees the prostate on a TV screen. He said right away that I had three separate lesions, one in the left as shown on the MRI scan and two in the right lobe, which was missed by the MRI scan. False negative lesions are common on MRI scans, which can become a source of cancer recurrence.

3-dimensional prostate biopsy

The following day he booked me for a 3-dimensional prostate biopsy via the perineal approach. The perineum is easy to sterilize, so there is no risk of septicemia. A metal grid with holes for biopsy needles was used to get 96 biopsies of my enlarged prostate. For a normal size prostate, Dr. Onik said about 60 biopsy needles are normal. You don’t feel anything, because you are asleep.

Cryoablation prostate surgery

Next was the cryoablation surgery of the 3 prostate cancer lesions. This happened one month after the biopsy. I was seen at the hospital in Ft. Lauderdale. The same grid from the biopsy was used to relocate exactly where the cancer lesions were. The pathologist had confirmed them as Gleason 6 and 7 prostate cancers. This was treated with Argon sounds and frozen twice. I felt nothing, because I was under a general anesthetic. But Dr. Onik told me that everything went very well. Some cancer was too close to the neurovascular bundle, so he used the NanoKnife, an invention where nano-size holes get blasted into cancer cells, but it leaves normal tissue intact.

I needed to do self-catheterization for about one month to empty my bladder, as there was a lot of swelling from the prostate hypertrophy and the surgery. But eventually my normal water works returned.

Follow-up blood work

My follow-up PSA blood work 3 months after the surgery was down to 1.0. Prior to the surgery the Oncoblot test was positive for prostate cancer. A repeat Oncoblot test 3 months after the surgery was now negative for prostate cancer. I realize that not every physician accepts this new cancer-screening test, but I felt a lot better to know that all the cancer markers were now gone.

9 cancer treatments reviewed

In my book I described a total of 9 prostate cancer treatments and their 10-year survival statistics. None of the other treatment methods were as good as Dr. Onik’s statistics. I believe it is linked to the precision of the 3-dimensional biopsy and the surgery being done through the same grid. If you do not perform the surgery this way, you miss cancer lesions and this becomes the source of failure 10 years down the road. My book details all these alternative treatments. It also has a section on lifestyle modifying factors. I needed to write this book as a service to any man who suddenly is faced with a possible diagnosis of prostate cancer.

Unmasking prostate cancer

Like me he needs to unmask the cancer. Is it really there? How far advanced is it? Which way to safely biopsy it (definitely NOT through the rectum for fear of blood poisoning=septicemia)? What is the best method to remove it? I came to the conclusion that Dr. Onik’s method was best for me. But with the information in this book you can decide what is best for you.

Medical Questions Answered

Finally I wrote my 4th book. From more than 4400 medical questions that I have answered on the site Quora.com I selected the most popular questions for this book. The editorial board of Quora said that I own the publishing rights for my answers. The questions were rephrased without changing the meaning. I selected more than 120 questions under 44 different headings.

Here are some of the areas that are covered: Acne, the best home remedies. Aging: can it be reversed? What is the limit for a human? Alcohol: how does it affect your body? Alzheimer’s disease: which foods promote brain health? Arthritis: what can you do about osteoarthritis? Back pain: what can I do about it? Cancer: why can cancer still not be cured? There are as well 15 other answers about cancer. Depression: will my depression ever go away? Diabetes: will a 600-calorie diet help diabetes control?

Further topics discussed

Diet: I want to get rid of sugar in my diet. How can I do this long-term? Other answers about diet are included. Exercise: How useful is cardiovascular exercise? Gut disease: Is “gluten free” food healthy? Heart disease: What can I do to clean out my arteries and reduce my risk for heart disease? Hormones: Is estrogen present in the male body? Life Expectancy: What is the theoretical life expectancy of humans? Lifestyle Habits: Can good habits change your life completely? Pain: Pain relief for a headache or other pain: Aleve, Advil or Tylenol? Pregnancy: Best age for a successful pregnancy? Prostate Cancer: How dangerous is prostate cancer? Does it kill you? Schizophrenia: What complementary approach may help a patient with schizophrenia? Sleep: What happens when you go to bed late every night? And many other answers under this topic.

And the book finishes with these topics

Sugar: will I be OK living without sugar? Vaccinations: Is there a connection between vaccinations and autism? Vitamins and supplements: Are taking vitamins and supplements healthy or are they harmful? Weight loss: I am working out every day, but I am not loosing weight. What should I do? There are many more answers under this topic. Younger for longer: What are three things I can do every day to stay younger for longer?

These are only a few selections of all of the topics dealt with in this book.

Writing A Medical Book

Writing A Medical Book

Conclusion

I have reviewed briefly why I published the books mentioned above. My prostate cancer book developed out of the necessity that I had to deal with my newly diagnosed prostate cancer in 2016. I felt that the review process I went through would be good for those men who have to face a similar situation. The anti-aging book comes from my interest in anti-aging medicine. “Healing Gone Wrong, Healing Done Right” developed from the observation that physicians in the past and often even now tend to only treat symptoms. But if a cause can be found, this should be treated, as this often leads to a permanent cure.

Treating symptoms only will not improve the patient’s condition

Treating symptoms only will not improve the patient’s condition. “Medical Questions Answered” is a collection of medical topics where I answered various medical questions. It was a way for me to cover a vast array of medical topics. Some of the topics are dealt with in depth (acne for instance); others are very short. I have also two medical blogs that come out on Wednesdays and Saturdays. I hope that some of that medical information will be useful to you.

Mar
24
2018

Prevent Plugged Arteries

There are several ways to prevent plugged arteries, which will translate into less heart attacks and strokes. The message is simple: if you get less heart attacks and strokes, you will live longer. Below I am examining ways to prolong life by various ways to prevent plugged arteries.

You probably heard of plaque formation in the arteries. This is the process where a combination of fat, calcium, cholesterol and cell waste forms a deposit (plaque) under the lining of the arteries.

The end result is that the blood won’t be flowing freely through the affected arteries. This can cause a heart attack or a stroke. Essentially, this is the point where a clot forms in the narrowed passage of the artery. It is also the point, when the clinicians make a diagnosis of a heart attack or a stroke.

Let’s examine what leads to plaque formation in the arteries.

Trans fats

Trans fats are contained in fried foods like French fries, in margarines and other butter substitutes. As margarine is a common ingredient of cakes, cookies, pastries and pies, these are all bad news for our heart health. I consider them off limits. If you eat those foods, you build up plaque in your arteries, which leads to premature heart attacks and strokes.

Lack of exercise

It has been common knowledge for a long time that being sessile leads to premature hardening of the arteries. In the late 1800s to the early 1900s physical exercise was promoted in various countries around the world.

The latter part of the 20th century saw a renaissance of the fitness movement. It was trendy to go running, cycling, and swimming or working out at a gym. It is not only trendy but healthy: cardiologists support all of these sports to help people stay healthy and keep the arteries free from plaque formation.

Too many refined carbs

Sugar and processed foods, especially those with added sugar to improve flavor, have a direct relationship to heart attacks and strokes. It is known that sugar causes high LDL cholesterol and high triglycerides. In addition sugar also causes inflammation of the arterial walls, which causes plugged arteries. However, sugar is only part of the problem. Starchy foods like rice, noodles, cakes, cookies and other foods made with flour get broken down into sugar. Both lead to insulin production. And both lead to changes of the lining of the arterial walls.

In the 1980s and 1990s there was a school of thought that a low fat diet would be healthy in terms of heart attack and stroke prevention (the low fat/high carb diet). This turned out to be a nutritional disaster: the high carb content of such a diet was the problem. It led to weight gain, obesity and death.

Red meat is a problem

Several studies have documented that saturated fat from red meat is only part of the problem. The other part is carnitine, which is abundantly present in beef, pork, lamb and venison. But mortality of people eating unprocessed red meat is only marginally elevated. It is when people eat processed red meat that there is a significant rise in mortality from heart attacks and strokes. This study examined this. They found that gut bacteria were stimulated by red meat to produce substances that stimulate bacteria in your gut to secrete TMA and TMAO, which makes your platelets more sticky and contributes to plugging your arteries. This research paper from the Cleveland Clinic explains it in more detail.

What must I do to prevent plugged arteries?

Eat the right food

A Mediterranean diet is anti-inflammatory. It contains lots of vegetables, but little red meat. Fish and chicken that contain much less L-carnitine are more dominant in Mediterranean food. As mentioned above, you want to avoid trans fats. And you also want to avoid sugar and too many starchy foods. This includes sugar-sweetened beverages. Making these changes will keep your insulin levels in the normal range eliminating inflammation in your arteries. Avoid eating processed foods, because they contain food preservatives and lots of sugar that we want to avoid. Eat more unsaturated fats like avocados, walnuts, olives, trout, herring, and salmon. The last three contain marine-derived omega-3 fatty acids that are particularly helpful in preventing heart attacks and strokes by being anti-inflammatory and by elevating the protective HDL cholesterol. Drink lots of green or black tea, rooibos tea, or ginger tea. They contain antioxidants and bioflavonoids that prevent plugged arteries.

Regular exercise

Many publications have shown that regular physical exercise will lower blood pressure, condition your muscles including your heart and lower mortality.

Only 10 minutes of brisk walking every day reduced the death rate by 33% compared to those who did not exercise at all.

Regular physical exercise does not only prevent heart attacks and strokes, it also reduces the risk of getting another 35 chronic diseases, as the link shows.

Here are some common exercises: jogging, cycling, running, brisk walking, swimming, playing tennis and doing aerobics. All of them will strengthen your muscles and condition your heart and lungs.

Other ways to prevent plugged arteries

Smokers must quit smoking, as smoking has been identified as a major risk factor for heart attacks and strokes.

Exposure to prolonged stress is a factor that leads to hardening of arteries. Stress management is possible by counseling, by self-hypnosis, yoga, tai chi and other relaxation methods.

Risk factors associated with plugged arteries

We already have mentioned the risk factors that are associated with clogged arteries. But for clarity I would like to repeat the major risk factors here.

  • Smoking
  • High blood pressure
  • Elevated LDL cholesterol (the bad cholesterol)
  • Reduced HDL cholesterol (HDL is increasing with exercise)
  • Obesity (often associated by ingestion of too many carbs)
  • Insulin resistance and diabetes
  • Lack of exercise (too much sitting in front of the TV or doing computer work)
  • Unhealthy diet (Standard American diet instead of Mediterranean diet)
Prevent Plugged Arteries

Prevent Plugged Arteries

Conclusion

We often think that we have no input whether or not we get a heart attack or a stroke. This is completely wrong. If you adopt the solutions I have listed here, you can change things for the better. You will reduce your risk to get a heart attack or a stroke. Treat high blood pressure. Stop smoking. Cut out sugar and starchy foods to reduce triglycerides and LDL cholesterol. Exercise regularly and your HDL will protect you from heart attacks and strokes. Shed pounds, if you are obese by starting a Mediterranean diet and cutting out sugar. This will also improve your insulin resistance or diabetes. Start daily exercise as this reduces your risk of a heart attack or a stroke. In addition exercise reduces the risk of 35 chronic diseases that have also been mentioned in one of the links.

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Mar
03
2018

Foods That Can Protect You From Cancer

There are foods that can protect you from cancer. Generally speaking you want to remove cancer-producing substances from your diet. But diet is only part of your lifestyle that can contribute to cancer. I will list some of the more important dietary factors below and briefly also touch on important other factors.

Avoid burning your meat 

When you use the BBQ, avoid burning your meat. As a matter of fact it is a lot better to use a slow cooker at low heat, and cook the meat for a longer time. In this way you won’t create carcinogens, which are cancer-producing chemicals. Healthy Grilling Tips to Minimize Carcinogens in Your Food. This is particularly important for the red meats (like beef, lamb, bison or pork).

Sugar can cause cancer

You never thought that sugar and an overabundance of starchy foods can cause cancer, but they do. 5 Reasons Cancer and Sugar are Best Friends.  What is the reason for this? The answer is found in the metabolism of cancer cells. Cancer cells use 10- to 12-times more sugar for their metabolism than normal cells.  Over-consuming sugar is the worst thing a cancer patient can do. Replace sugar by stevia, which is a harmless sweetener. It does not lead to an insulin reaction. You need to avoid all other sugar substitutes as there are other health problems associated with them.

Avoid macaroni and cheese because of phthalates

Avoid macaroni and cheese: Phthalates are found in almost every sample of cheese powder used to manufacture macaroni and cheese. Phthalates can cause infertility and breast cancer. Toxic effects of the easily avoidable phthalates and parabens.

High fat diet

A high fat diet increases the risk for breast cancer: High-Fat Diet Increases Breast Cancer Risk, Study Finds. Limit your fat intake to about 10% of saturated fat. That is the recommendation of the FDA: New FDA Food Guidelines – Medical Articles by Dr. Ray. Increase your consumption of fish and seafood. Only one proviso: predator fish like shark, marlin, tilefish, swordfish and grouper are high in mercury. But wild salmon, sardines and oysters are low in mercury; so are shrimp and squid. Before You Buy Fish, Check This Mercury Level List.

Take high dose vitamin D3 supplements

In order to avoid cancer, take high dose vitamin D3 supplements to avoid cancer. Vitamin D3 in cancer prevention and therapy: the nutritional issue. Strong statistics exist showing that vitamin D3 is a powerful tool to lower your risk of developing cancer. Your family doctor should take a blood test called 25-hydroxy vitamin D level to monitor that you absorb enough vitamin D3. Some people absorb vitamin D3 slowly and fast absorbers absorb it more rapidly.  The only way how to find out how well your gut is absorbing vitamin D3, is by doing this blood test. It is now generally accepted that a good range of the 25-hydroxy vitamin D level is between 50 and 80 ng/ml.

Also curcumin 500 mg per day is good for cancer prevention. Turmeric | Cancer in general | Cancer Research UK.

Take enough fiber

Make sure you take enough fiber, which does not only reduce colorectal cancer, but also many other cancers. Foods for Cancer Prevention. North Americans are not consuming enough fiber. Vitamin D3 in cancer prevention and therapy: the nutritional issue.

Avoid processed meat

The World Health Organization has determined that processed meat is causing a lot of cancer. They labeled processed meat as a probable carcinogen. Processed meat causes colorectal cancer, pancreatic cancer and prostate cancer.

Moderate amounts of fruit and vegetables

Eat moderate amounts of fruit and vegetables. The claim in the past that fruit and vegetables would protect you from cancer is not as solid as it was thought of in the past. Newer research has shown that a basic intake of fruit and vegetables is needed for essential nutrients, but consuming more than that will NOT protect you from cancer. Fruit and vegetables and cancer risk. This is a case where eating more vegetables or fruit beyond a certain point will not do harm, but it will not protect you further from cancer.

Drink green tea or black tea

Drink green tea or black tea, sweetened with stevia for cancer prevention: Winter Beverages for Cancer Prevention. Green tea contains polyphenols and antioxidants. One of the antioxidants is called catechin, which prevents cell damage. The antioxidants help to prevent breast cancer, colorectal cancer and prostate cancer. In addition tea is heart healthy.

Avoid alcohol consumption 

Avoid alcohol consumption as much as possible to prevent cancer: Drinking Alcohol Really Does Raise Your Cancer Risk, Doctors Warn. We were indoctrinated by cardiologists that one glass of wine per day for women and two glasses of wine per day for men would be a prevention against heart attacks. But these relatively small amounts of alcohol do have an effect on causing cancer.  This British study showed that small amounts of alcohol indeed are cardioprotective. In contrast, these amounts and higher alcohol amounts can also cause cancer of the pharynx, larynx (voice box), esophagus, liver, breast, colon and pancreas.

Avoid too much red meat consumption

Beef, lamb and pork probably contribute to causing cancer according to the WHO. Use common sense, and eat more fish, chicken and turkey. Reduce your beef consumption. My grandmother said when I grew up in Germany that beef was a meal reserved for Sunday dinner only. The rest of the days we ate little in the way of meats, but lentils, beans, eggs or fish instead. Ask your grandmother, what she used to cook. Or ask your mother what she ate as a child.

Other lifestyle issues

Quit smoking, if you still do. This is by and large the biggest risk for developing lung cancer, throat cancer, esophageal cancer and pancreatic cancer. Watch your calorie intake: eat smaller meals more often. This way the production of your digestive juices will consume some calories and because you satisfied your hunger for foods, you will not gain weight. This will help prevent obesity and type 2 diabetes, both of which are established risks for developing cancer. Here is a review that shows you, which cancer types are caused by obesity: Obesity and Cancer . With regard to diabetes, there is a strong association with developing liver cancer, pancreas cancer and endometrial cancer (=uterine cancer). There is a lesser risk (only 1.2 to 1.5-fold) to develop colorectal cancer, breast cancer and bladder cancer. Diabetes and Cancer: A consensus report.

Pollution can also be a factor in causing cancer: How air pollution can cause cancer. If you can move to a less polluted city, do so.

Foods That Can Protect You From Cancer

Foods That Can Protect You From Cancer

Conclusion

As shown above there is strong evidence that certain foods can cause cancer. Others, including supplements like curcumin and vitamin D3, can help prevent cancer. If we avoid as many of the known cancer producing foods and eat more of the healthy foods that do not cause cancer, our cancer risk will decline significantly. In addition, if you quit smoking, avoid pollution as much as possible, reduce your alcohol intake and watch your calorie intake to prevent obesity and type 2 diabetes, you will move into the low-risk cancer group. We all need to work on this on an ongoing basis.

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Sep
23
2017

Close Diabetes Control Prolongs Life

 

A 20-year study showed that close diabetes control prolongs life. A study divided 160 people with diabetes into two groups. The one group continued to get standard care. Yet the other group received a multi targeted, aggressive treatment protocol. As a result after 20 years the group with the intensive treatment protocol lived 7.9 years longer than the group with the standard treatment.

Dr. Oluf Pederson was the senior investigator of the physician team that followed the diabetes group. He said that they concentrated on a number of known adverse factors and treated them aggressively. These factors were first of all high blood glucose values and clotting risks, also high blood pressure and high triglycerides and in addition cholesterol values. Behavior modification was the therapeutic method to get people with risk factors to exercise more, adopt a healthy diet and stop smoking. Medication in select cases also played a role.

More details about the study

The intervention of intensive treatment lasted 8 years. After that the patients were still in a follow-up study for 13 years. At the beginning of the study patients were on average 55 years old and were borderline obese.

The investigation team screened for complications of diabetes. This included screening for kidney disease, heart disease and blindness. Dr. Joel Zonszein, the director of the New York Clinical Diabetes Center at Montefiore Medical Center said: ”These results are impressive and most patients do not receive the correct treatment, according to national surveys.”

Other studies about diabetes  

Foreign studies

Study from Croatia
  • Another study from Croatia involved 200 patients. It concentrated on patients who did not respond to metformin. Physicians used alternative treatment modalities, and they observed and measured blood sugars and hemoglobin A1C in the following 6 months. The study concluded that those patients who received aggressive treatment of their condition did better than those who did not receive the same vigorous approach.
Study from Japan
  • This Japanese study documented that female patients with type-2 diabetes developed kidney damage earlier than their male counterparts.  Consequently, the investigators pointed out how important it is to treat diabetes aggressively to avoid kidney damage.
Study from Singapore
  • This 2016 study from Singapore analyzed retroactively the impact of diabetes on the long-term survival after coronary bypass grafting (CABG).  5720 consecutive patients had their isolated first CABG surgery between 1982 and 1999. The mean follow-up was 13 years. 34.6% of the patients had diabetes, 51% had high blood pressure and 46.6% had elevated blood lipids. The initial mortality after the CABG surgery was 2.4% in the diabetic group and 1.8% in the non-diabetic group. 20-year survival rates following CABG surgery were 30.9% in diabetics and 49.2% in the non-diabetics, an 18.3% difference. The 20-year freedom from cardiac mortality rates was 56% in diabetics and 68.4% in non-diabetics. Other risk factors that led to cardiac mortality were the following: female gender (1.43-fold risk), diabetes (1.51-fold risk), previous heart attack (1.54-fold risk) and a low left ventricular ejection fraction of less than 35% (2.6-fold risk). The conclusion from this study was that long-term survival in diabetics following CABG surgery was much lower than that of non-diabetic controls. Hence the key to improving long-term survival for diabetics is to treat comorbidities like high blood pressure and elevated lipids aggressively as well as getting blood sugars and hemoglobin A1C values under control.

US studies

  • In this US study 558 youth (age less than 21) between February 2012 to July 2015 received follow-up. Between 40% and 50% of these diabetics needed insulin to improve their diabetes. Unfortunately their diabetes showed poor control, as their high hemoglobin A1C values indicated. Median HbA1C was 6.7%, 8.5%, 9.6%, and 9.7% in those with disease duration less than 1 year, 1-2 years, 2-3 years and less than 4  In other words, the longer the young patients had diabetes, the less seriously they took their treatment. Only 33% treated their high blood pressure and only 11% their elevated blood lipids. Microalbuminuria, an indicator of diabetic kidney disease, and non-alcoholic fatty liver disease were present in 5% to 6% of these young diabetic patients. The authors came to the conclusion that there were serious gaps in treating these young diabetics. Further follow-up data of the same group of patients in the coming years will provide further data. In conclusion, the new hemoglobin A1C ranges of 3.8% to 4.9% as the new normal range explains why these youths who do not treat their diabetes properly are at high risk to develop complications from their poorly controlled diabetes.
Heart attacks and erectile dysfunction
  • Heart attacks are more common among patients with uncontrolled diabetes. This US study classified diabetics according to the tightness of their diabetes control. Researchers found examining 606 men and 606 women with diabetes that they could reduce their risk of a heart attack, if they controlled smoking, glycated hemoglobin (hemoglobin A1C), systolic blood pressure, and total and high-density lipoprotein cholesterol. The control of all these risk factors could contribute to the prevention of heart attacks. 35% of men and 45% of women could prevent having a heart attack. A laxer control still would prevent 36% of heart attacks in men and 38% in women. A very aggressive diabetes control could prevent 51% of heart attacks in men and 61% in women. Most noteworthy: close diabetes control prolongs life.
  • Erectile dysfunction (ED) is a big problem among diabetic men. This study from Seattle shows the investigation of 136, 306 men with erectile dysfunction. 19, 236 of these men had diabetes prior to their ED problem. Over a two-year observation period diabetic men had much worse ED problems. As a result they needed to receive secondary line treatments  like penile suppositories or injectables. Others needed tertiary treatments like penile prostheses. In those whose diabetes control was good, oral agents as first-line therapies were usually sufficient.
More studies about risks and benefits of lifestyle
  • Middle-aged women with diabetes have a 4- to 5-fold higher risk for developing heart attacks while men do not show such a higher risk. It is probably particularly important for women to control diabetes when they are diagnosed with it to reduce the risk of coming down with a heart attack.
  • In 2011 Taylor from Newcastle University showed in a group of diabetes patients that he could cure diabetes permanently with an extremely low calorie diet. The trial was simple: he took overweight or obese patients with diabetes and put them on a starvation diet of 600-700 calories per day for 8 weeks. Consequently 43% of diabetic patients received a permanent cure of their diabetes. More info: http://nethealthbook.com/news/cure-diabetes-permanently/

 

Close Diabetes Control Prolongs Life

Close Diabetes Control Prolongs Life

Conclusion

The new hemoglobin A1C ranges that are desirable are between 3.8% to 4.9%. When diabetics bring their hemoglobin A1C level into this range, they do not get complications from their previously poorly controlled diabetes. Close diabetes control prolongs life. But as can be seen from a brief review of the literature physicians tend to be lax, patients are lax, and diabetes is often not well controlled. This leads to erectile dysfunction in males, to heart attacks and kidney failure in both sexes. Blindness and painful diabetic neuropathy are also common complications of poorly controlled diabetes. Amputations from clogged arteries are also among the complications. “Close diabetes control prolongs life” is the new mantra that everybody with diabetes needs to follow.

Lifestyle changes control diabetes and prolong life

As stated above Dr. Taylor from Great Britain has shown that a brief 600 to 700 calorie diet can cure 43% of diabetic patients permanently. Quit smoking, bring the glycated hemoglobin (hemoglobin A1C) into the normal range, control your systolic blood pressure as well as your total and high-density lipoprotein cholesterol. Do all these things, exercise regularly, and your diabetes will be well controlled. Remember: close diabetes control prolongs life!

May
20
2017

Prevention Of Telomere Shortening

Dr. Mark Rosenberg gave a talk on prevention of telomere shortening. This was presented at the 24th Annual World Congress on Anti-Aging Medicine (Dec. 9-11, 2016) in Las Vegas that I attended. The detailed title was: “The Clinical Value of Telomere Testing”.

What are telomeres?

Telomeres are the caps at the end of chromosomes. They are very important in the aging process. Prematurely shortened telomeres are linked closely to all major diseases like cardiovascular disease, cancer, diabetes and more. Telomeres are also a measure of the aging process. Aging occurs due to a decrease of the number of cells in organs and/or because of a lack of functioning of these organs. Telomeres get shortened every time a cell divides. But when the telomeres are used up, there comes a time when cells can no longer divide. These cells become senescent cells or they enter apoptosis (programmed cell death).

The senescent cells can become a problem when they get transformed into cancer cells and their telomeres lengthen again. These cancer cells divide rapidly and this can become the reason why cancer patients to die.

What is the significance of telomeres?

Telomere dysfunction is the first sign that the telomeres are getting shorter in a person compared to the average telomere length in a comparable age group. This is not only important for aging, but also has clinical implications. The shorter telomeres are, the higher the risk for cardiovascular disease. Telomere length also provides prognostic information about the mortality risk (risk of dying) with type 2 diabetes and for many cancers. Many physicians incorporate a telomere blood test into periodic health checks, if the patient can afford it.

Interventions that help telomere length

Here are a number of things we can do to lengthen our telomeres.

  1. Rosenberg mentioned that the strongest effect on telomere lengthening comes from caloric restriction and weight loss. 80 years ago they showed at the Cornell University that rats put on calorie restriction had a 30% increase in their mean and maximum lifespan. Many research papers have confirmed that the same is true in man and that the common denominator is telomere lengthening.
  2. Next are regular physical activity, meditation, reduction of alcohol consumption and stopping to smoke.
  3. Taking antioxidants and omega-3 fatty acids regularly will also lengthen telomeres.
  4. Improving one’s dietary pattern by adopting a Mediterranean type diet that contains cold-pressed, virgin olive oil.
  5. Telomerase activators. Here is some background on the TA-65 telomerase activator, which is based on Chinese medicine. A one year trial was completed with 250 units and 1000 units of TA-65 per day. The lower dose (250 units) showed effective telomere lengthening, while the placebo dose did not. The 1000 unit dose did not show statistical significance.

Should you wish to take TA-65, only take 250 units per day, not more.

Cancer and telomeres

There is a strong correlation between cancer and telomere shortening. When cells are at the brink of dying toward the end of their life cycle the telomeres get shorter and shorter. This is the point where the cells can turn malignant. Certain genetic abnormalities help the malignant transformation, like 11q or 17q deletions or a p53-dependent apoptosis response. Once cancer cells have established themselves they activate telomerase in 85% of cases. In the remaining 15% of cancer cases telomeres are activated through telomerase-independent mechanisms. Here are a few examples.

CLL

CLL stands for chronic lymphocytic leukemia. It is a disease of the aging population. At age 90 people’s bone marrow cells have a telomere length of only 50% of the length at birth. This is the reason that in older age CLL is more common. Researchers observed a population segment and found that the shorter telomeres were, the poorer the overall prognosis and overall survival for CLL was.

Lung cancer

Researchers examined the telomerase activity in patients with non-small cell lung cancer. When telomerase activity was present, the 5-year survival was only 55%. When telomerase activity was absent, the prognosis was 90% survival after 5 years.

Prostate cancer

  1. Prostate cancer risk correlated with telomere shortening in stromal cells. Men with shorter telomere length in stromal cells had a 266% higher risk of death compared to men with normal telomere length.
  2. Another study took blood samples and determined the telomere length in lymphocytes (the immune cells). Those men who came down with prostate cancer within a year after they had their blood sample, had short telomeres. The risk for prostate cancer in these patients was 355% higher than in the prostate cancer negative controls.

Yet another study looked at surgical tissue samples from 596 men that

Underwent surgery for clinically localized prostate cancer. Patients whose samples showed variable telomere lengths in prostate cancer cells and shorter telomeres compared to prostate samples with less variable telomere length and longer telomeres had a much poorer prognosis. They had 8-times the risk to progress to lethal prostate cancer. And they had 14-times the risk of dying from their prostate cancer.

Breast cancer

Breast cancer is diverse and consists of cases whose origins are genetic (BRCA1 and BRCA2), but there are also cases where the cancer is local or has a higher stage. In families with mutated BRCA1 and BRCA2 telomeres are significantly shorter than in spontaneous breast cancer. Increased telomerase activity in breast cancer cases is directly related to how invasive and aggressive the breast cancer is.

  1. In one study researchers analyzed blood leukocytes in 52 patients with breast cancer for telomere length  versus 47 control patients. Average telomere length was significantly shorter in patients with a more advanced stage of breast cancer than in early breast cancer. Mutated HER patients had the shortest telomeres. It follows from this that checking for the HER status and blood telomere testing adds to the knowledge of potential cancer development and prognosis.
  2. In patients with with larger breast tumors, more lymph node metastases and more vascular invasion the researchers found short telomere length of the cancer cells.
  3. More aggressive breast cancer cells have higher telomerase activity. More than 90% of triple negative breast cancers have short telomeres.

CNS disorders and telomeres

Dr. Rosenberg presented evidence for a correlation between shorter telomeres and the development of dementia. But dementias with Lewy bodies and Alzheimer’s disease are also linked to short leukocyte telomeres. The length of blood telomeres predicts how well stroke patients will do and how people with depression will respond to antidepressants.

Cardiovascular disease and telomeres

The renin-angiotensin-aldosterone system controls our blood pressure and keeps it constant. When this system is not stable, our blood pressure shoots up and causes cardiovascular disease. This is tough for the heart, as it has to pump harder against a higher-pressure gradient. A study of 1203 individuals was examining the connection between leukocyte telomere length and renin, aldosterone and angiotensin II activity. It concluded that oxidative stress and inflammatory responses affect the telomere length of leukocytes and that the more stress there is in the renin-angiotensin-aldosterone system, the more cardiovascular disease develops. The conclusion of the study was that the overall cardiovascular stress leads to shortening of leukocyte telomeres.

Prevention Of Telomere Shortening

Prevention Of Telomere Shortening

Conclusion

Telomere length testing from a simple blood test will become a more important test in the future as hopefully the cost comes down (currently about 300$). It can predict the general aging status by comparing a single case to the general telomere length of the public. But it can also predict the cancer risk, risk for mental disease and cognitive deficits (Alzheimer’s disease). In addition your cardiovascular status correlated globally with this test. What are the options for the patient, if the test comes back with short telomeres?

It allows you to change your lifestyle and adopt a healthy diet. You can exercise regularly, take antioxidants and meditate. There are even telomerase activators that are gradually becoming more known. They lengthen the telomeres. The cost of telomerase activators will likely still be a problem for some time. All in all telomere length tests are here to stay, but healthy lifestyle choices are the only tool for effective intervention at this point. This is good news: healthy lifestyle choices like non-smoking, exercise and avoiding non-processed foods are either free or have a reasonable price tag. Telomerase activators are big business and at this point not really affordable!

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