Mar
15
2014

Mold Allergies Often Overlooked

In a recent news story extensive mold infestation was found in a house that had oriented strand boards (OSB) instead of plywood walls. The house also was tightly sealed trapping moisture, which contributed to the extensive mold problem.

Mold problems have been around for centuries, but only in the past few decades allergists  have pointed out to their patients how important it is to prevent this from happening.

In the following I will review a few typical scenarios that can lead to mold accumulation.

1. Mold from airtight house construction

The homeowner described in the link above is not the only case in the world that has a mold problem. Energy efficient homes are popular because they save energy costs; homeowners often also respond to gas companies, electric utility companies and government incentives to convert to airtight home construction.

In the 1980’s the construction industry introduced the cheaper OSB products to replace the more expensive plywood for wall construction. This is often the problem with newer house construction. However, older homes are not immune to mold development.

2. Roof leaks in older homes

Older homes that were built in the 1970’s may have plywood walls and have a bit of airflow from poorer wall construction, which would prevent mold formation. But roofs are older and do not always get replaced right away when a leak is detected. It may even take some time in areas where there is less precipitation before it is picked up during a particularly heavy rainstorm. Water that enters from a leaky roof can form a puddle on top of the ceiling where mold softens the drywall material until a leak in the ceiling causes water to drip down onto the floor. The mold spores multiply particularly well in wall-to-wall carpeting, but OSB material is also a good growth opportunity for molds due to the mini air spaces between the glued wood pieces. Plywood with its several tight layers is much more resistant to water penetration and mold growth.

Mold Allergies Often Overlooked

Mold Allergies Often Overlooked

3. Mold growth after hurricanes

After hurricane Sandy images of “black mold” were frequently shown in the media. The problem is that after 48 hours anything that was in contact with water produces mold. However, often with disasters like hurricanes there are evacuation orders and you cannot return to your home for several days. There may be further delay because there is a waiting period for insurers to assess the amount of damage, before you can clean all surfaces affected by mold.

The end is result often that expensive mold sanitation is needed or the person ends up moving away and the house is levelled before a new house can be built.

4. Effects of molds

People with preexisting allergies and asthma are more susceptible to the effects of molds. It leads to itchy eyes, wheezing, coughing, and exacerbation of asthma.

Here is a brief overview what the CDC is stating about mold. This site also explains that you can recognize a mold problem because of a musty smell or foul stench in the air and because of the appearance (discoloration of ceilings or walls, water damage).

You can clean hard surfaces with bleach water. Bleach kills molds, but it may have to be cleaned several times within a few days to get rid of the last spores. Whatever cannot be sanitized in this way must be removed or replaced.

5. Health concerns regarding molds

Ref. 1 reviewed the public concern about the toxic effects of molds. It noted that with the Internet and the popular press having exaggerated some of the connections of symptoms with mold allergies, the term “mold madness” has been coined (Ref.2). Despite the paranoia in the general public about toxins from molds, there is only a small percentage of the population that is sensitive to molds where IgE antibodies and IgG antibodies against molds can be determined through blood tests. These individuals often are also allergic to other environmental allergens like grass pollen and dust mites. The asthmatic reactions in sensitive people are not as severe as what peanut traces would do to peanut sensitive patients, but skin testing and blood test screening for specific IgE and IgG antibodies do often confirm that sensitive people indeed can have specific mold allergies. In the vast majority of people these tests are negative and correlations between mold infestations and allergic reactions could not be verified (Ref.1).

6. Fixing mold damage and dealing with allergies

It follows from this that you should remove any visible molds and fix whatever the cause was for its appearance. Carefully disinfect the areas with diluted bleach water (the CDC recommends 1 cup of bleach per 1 gallon of water) several times. Make sure the areas are dry and not musty otherwise you  have  work on improving ventilation. If you are not one of these hypersensitive persons, there is nothing to worry further. However, if you are hypersensitive an allergist should examine you. Common indoor molds that cause the so-called “immediate type hyper reactivity” are due to the mold species Aspergillum and Penicillium. Most outdoor molds that can cause problems for sensitive people are due to Alternaria and Cladosporium species. The latter would be the ones found in carpets after a leaky roof has caused problems. When the allergist has found specific allergies to one or several of the mold species, allergy shots may be prescribed that would have to be given weekly to the sensitive person who was found to have environmentally induced asthma. Often it takes several years for these desensitization shots to stop the affected person from reacting  to molds. In some cases patients need to stay on these shots life-long.

Conclusion

The key with regard to mold allergies is to prevent mold growth by being vigilant about detecting early problems with leaky roofs, walls and cleaning up water damage right away. When there is a musty tell- tale smell, investigate right away and remedy the problem. For most people this is the end of the story. However, a small percentage of very sensitive people need to consult with an allergist who should investigate whether or not these people would benefit from allergy injections.

In some rare cases the affected person may have to relocate to another house that is free from molds.

More information about asthma: http://nethealthbook.com/lung-disease/asthma-introduction/

References

1.Shannon: Haddad and Winchester’s Clinical Management of Poisoning and Drug Overdose, 4th ed. Copyright 2007 Saunders

2. Zacharisen MC, Fink JN: “Is indoor “mold madness” upon us?” Ann. Allergy Asthma Immun. 2005; 94:12-13.

Last edited Nov. 7, 2014

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Mar
08
2014

Protecting Yourself From Environmental Toxins

Environmental toxins are toxins that may be in your drinking water, in what you eat, in the air you breathe, or they enter your body through your skin when you swim in contaminated water or walk on a sandy, wet beach.

In the following blog I will address some of these issues and how we can defend ourselves against toxins.

The youngest and most vulnerable

Toxins are particularly bad for infants and premature babies.

The reasons for this are the following ones: their kidney function (tubular secretion) is only 20% to 30% of that of an adult; the cytochrome P-450 enzyme system in the liver, one of the toxin eliminators is slowed down to only 25% to 50% of the adult activity and glucuronidation in the liver, another detoxification process, reaches adult levels only at the age of 3 years. The kidneys and the liver are limiting the removal of toxins by way of urine and bile in the newborn. Stomach acidity in a premature has a pH of 4.7, in a full-term newborn 2.3–3.6 and in an adult 1.4–2.0. This is important to note as a lack of stomach acid increases susceptibility of newborns and infants to gastrointestinal infections and cause diarrhea. Percutaneous absorption in newborns is much higher than in adults, which makes them very susceptible to absorbing toxins through the skin (Ref.1).

Diabetes from environmental toxins

Environmental toxins can cause insulin resistance and type 2 diabetes.

Bisphenol A (BPA) is used to make polycarbonate and epoxy resins and is found primarily in food and beverage containers. The world population has been exposed to this since 1957 and as a result 90% of US residents have detectable levels of BPA in their urine. Ref.2 explains that the higher the urine concentration of BPA, the higher the risk is for developing diabetes.

Persistent organic pollutants are another source of concern: pesticides and herbicides, dioxins, polychlorinated biphenyls, hexachlorobenzene, and hexachlorocyclohexane have all been found in humans. Several investigators have shown that virtually all of the risk in obese patients to develop diabetes comes from the fat-soluble persistent organic pollutants (Ref.2).

Inorganic arsenic is another pollutant that is found in soil and rock naturally and finds its way into the drinking water. About 8% of the public water system of the US exceeds 10 mcg/L for drinking water, which has been set as the safe limit for drinking water by the US Environmental Protection Agency’s standard. Anything above those levels is considered toxic.Ref.2 describes that people who ingest inorganic arsenic will excrete it in the urine; the highest group with arsenic in their urine had a risk of 3.58-fold to develop diabetes when compared to the lowest group. Curiously enough organic arsenic that is found in fish and shellfish is excreted in the urine unchanged and does not cause diabetes. Overall this indicates to me that nobody should consume or cook with contaminated water that contains inorganic arsenic. Reverse osmosis filters will protect you from this risk.

Protecting Yourself From Environmental Toxins

Protecting Yourself From Environmental Toxins

Other toxins around the house

Volatile organic compounds are often contained in carpets, but also in laser and inkjet printers. They are part of everyone’s life as this link shows. Varied symptoms like irritation of eyes, nose or throat, breathing problems, headaches, loss of coordination, damage to the liver, kidneys and the brain have been reported after exposure to volatile organic compounds. Long-term exposure can even cause cancer in animals and has been suspected to cause cancer in humans as well.

Air fresheners and cleaning solutions that contain ethylene-based glycol ethers and terpenes have been the subject of a study that examined concentrations in the air and interaction with ozone that can also be released by some cleaners. As this link shows the investigators concluded that with exposure to high enough concentrations and long enough exposures to these fumes lung cancer can be caused in cleaning personnel. They recommended to use cleaning solutions only in diluted form and to air out the premises well after cleaning. Another component of many air fresheners and cleaning chemicals is paradichlorobenzene, the same chemical that is contained in mothballs.

There have been problems with flame retardants: polybrominated diphenyl ethers, which are cancer producing; they have been outlawed in the US since 2004, but older mattresses, upholstery, television, computer casings and circuit boards may still contain them.

Lead and mercury poisoning, and radioactive pollutants

Manufacturers were not allowed to use lead in paints anymore since 1978. Paint from buildings older than that still may contain lead. There have been serious lead poisonings in children who were gnawing on items painted with lead containing paint. Lead causes problems with your central nervous system, brain, blood cells and kidneys. Just last year a news story about lead found in fashion jewelry surfaced warning about cheap fashion jewelry from China. Lead form these items can be absorbed through the skin and cause lead poisoning. Because of the apparent lack of regulations in China it is my recommendation not to buy anything that goes into your mouth or on your skin, if it has been grown or produced in China.

Mercury from tuna and other predator fish: It is sad that the oceans are polluted to the point where it has become unsafe to eat predator fish as there is an accumulation of mercury through the food chain.

How did things develop this way? Back 100 years and more ago gold panning and the purification process of gold caused mercury to enter into rivers and allow mercury to end up in the oceans where it has since accumulated; it just sits there as it has nowhere to go.

Coal burning (yes, there is mercury in coal) has also contributed to this by smoke being emitted from smoke stacks containing mercury vapors, which ended up returning to earth as polluted rain and drained through the river system into the oceans.

It is monomethylmercury that accumulates in the tissue of humans. It affects many organs, such as the brain, kidneys, lungs, and skin. It causes various symptoms like red cheeks, fingers, and toes; there can be bleeding from the mouth and ears; it can cause rapid heartbeats, high blood pressure, intense sweating, loss of hair, teeth, and nails. It also can cause blindness, loss of hearing, impaired memory, and lack of coordination, disturbed speech and birth defects. You may think all mercury comes from the outside. However, silver amalgam fillings in your teeth could also be the source of mercury poisoning. It is a good idea to replace amalgam/mercury fillings with ceramic fillings.

There are many forms of other marine pollution as this link shows.

One particular concerning aspect is pollution with radioactive materials as the Fukushima disaster in Japan has shown. Following the catastrophe on March 11, 2011 there have been several leaks of radioactive material into the ocean, which are described here. Dr. John Apsley II pointed out that with the explosions in Fukushima there were also several releases of radioactive pollution into the stratosphere. This pollution has subsequently traveled around the globe and has come down as radioactive rain. He has made it his ambition to help people minimize radiation exposure from nuclear accidents such as Fukushima.

Protecting yourself from toxins

Having said that pollution and toxins are problems that we are living with, how can we protect ourselves from all of that?

1. Avoid as many unsafe chemicals around you as you can. This includes checking ingredients in hair care and body care products, toothpaste, hair dyes, cosmetics, mouthwashes and underarm deodorants.  I have written a blog about toxins in the bathroom and what you should watch for.

2. I would recommend you switch from a standard food to organic food. It has become unsafe to eat non-organic meats, leafy vegetables, vegetables and fruit. There are too many residues of herbicides and pesticides contained also in meat, not only in vegetables and fruit. Washing will not remove these substances, even though some merchants may tell you otherwise. Buyer beware!

3. Detoxification methods are available and I have reviewed them in this blog. Briefly, to remove lead and mercury a formal intravenous chelation protocol should be followed.  Depending on how many heavy metal toxins you have on board, you may need only a few treatments or else up to 20. Here is a more conservative website stating that it would be safe to have silver amalgam fillings. I think that gold and ceramic fillings are much safer.

4. Genetically modified food is another danger as I have summarized in this blog. This is another reason why I like to stick to organic food. There is evidence that GMO food causes autoimmune diseases, infertility and chronic inflammation that can eventually lead to cancer. It may take decades to prove this, but I am not willing to be a human guinea pig.

5. I have mentioned in a prior blog that we live in a toxic world. You need to carefully look at your home and remove toxins. You need to assess your drinking water. A water analysis can tell you how good the water in your home is and whether there are concerns about inorganic arsenic. Usually places that sell filter systems can advise you in that regard. Your drinking water should either be bottled pure water or else reverse osmosis water that can be part of a filter system in your house.

6.Vitamins and supplements have been shown to support your cell integrity and have anti-inflammatory and antioxidant effects that protect you from toxins. I discussed this in detail in my NetHealthBook under nutrition. For instance vitamin D3 in doses of 5000 IU or more and CoQ-10 are powerful anti-inflammatories and CoQ-10 is also an antioxidant and preserves mitochondrial function. High fish oil supplements (3 to 6 Grams per day) have anti-inflammatory effects and protect your cell membrane integrity. With these overlapping qualities of vitamins and supplements your body will be in a much stronger position to defend itself against the negative effects of toxins. When you take multivitamins, this translates into telomere lengthening of 5.1% (or converted into a survival advantage of 9.8 years when it is accumulated over a life time). Ref. 4 explains this in more detail.

7. Exposure to radioactive substances is a scary thought, but this is becoming more and more a reality, at least for those who live close to disaster areas such as the Fukushima site in Japan or the Chernobyl site in the Ukraine. But according to Dr. Apsley II low dose radiation that we have already received in the US and in Canada following the Fukushima disaster is equally disastrous (Ref.3). Many of the vitamins and supplements I have mentioned are also cell and mitochondria protective and will help with DNA repair following radiation damage, but you must avoid sugar and other refined carbs and starches to reduce the oxidative effect on cells and on LDL cholesterol to prevent premature aging and cell death. Ref. 3 contains a lot more detail about this and explains what specific supplements can be taken to detoxify your system from specific radioactive elements that function as free radicals. There are specific antidotes for radioactive iodine-129 and iodine-131, radioactive cesium-137 and others.

Conclusion

Many people shrug their shoulders when they hear that pollution has an effect on their lives. They feel that they are powerless and cannot do anything about this. The truth is far from this! Above I mentioned seven points that you can follow to counter toxins. On top of that you can get politically active and urge your government representative to create a nuclear free zone in your area. Ref. 3 contains compelling evidence why this is so important not only for us now, but for future generations and the future of mankind. We need to hold those who provide us with food and beverages accountable for the quality of these. Shrugging it off is not good enough. Get involved. Buy organic food. Avoid the section in the grocery store where sugar and high carb foods are sold. It’s good for your own health, but it will collectively change the mentality of the grocery store owners who will notice that they are stuck with the comfort foods that sold well in the past. This new trend will result in cheaper prices for healthy foods and more availability of organic food.

References

1. Shannon: Haddad and Winchester’s Clinical Management of Poisoning and Drug Overdose, 4th ed. © 2007 Saunders. Chapter 18:“Toxicologic Issues in the Neonate”.

2. Rakel: Integrative Medicine, 3rd ed. © 2012 Saunders. Chapter 31: “Insulin Resistance and the Metabolic Syndrome”.

3. Dr. John W. Apsley II : “Fukushima Meltdown & Modern Radiation: Protecting Ourselves and Our Future Generations” © 2011. Temet Nosce Publications, Sammamish, WA 98075

4. Xu, Qun, Parks, C.G., DeRoo, L.A., Cawthon, R.M., Sandler, D.P. and Chen, H. Multivitamin use and telomere length in women. American Journal of Clinical Nutrition 89 (April 2009):1857-63. Full text (PDF): http://ajcn.nutrition.org/content/89/6/1857.full?sid=9aab0e13-b4d2-42ad-b44c-15cffc6771c3

Last edited March 8, 2014

Jan
18
2014

The Super Powers Of Vitamin D

Originally, when vitamin D was found to be the missing ingredient in preventing rickets in growing children the recommended daily allowance (RDA) to prevent rickets was found to be 400 IU of vitamin D. The active metabolite has been identified as vitamin D3 for which the body has receptors on all vital organs (heart, brain, bones, kidneys, liver). In recent years new insights have been gained as it turns out that the RDA’s were set much too low for many diseases that can develop when vitamin D intake is too low, particularly in the aging population. Higher doses of vitamin D3 in the range of 800 to 1000 IU per day have been shown to prevent osteoporosis, falls and fractures in older adults and in nursing home populations. But the immune system of everybody is dependent on higher doses of vitamin D3. Recently (Dec. 12 to 15, 2013) I attended a lecture at the A4M conference in Las Vegas where Dr. Eisenstein reviewed the latest on vitamin D3. It is now known that 2/3 of the US population is deficient for vitamin D as measured by blood tests (less than 25 ng/ml).  The standard test is the 25-hydroxy-vitamin D level (abbreviated as 25(OH)D level). It is now known that you require at least a level of more than 40 to 60 ng/ml of 25(OH)D as measured in the US, which translates to more than 100 to 150 nmol/L measured in metric units in other countries, to prevent cancer.

The Super Powers Of Vitamin D

The Super Powers Of Vitamin D

Metabolism of vitamin D3

90% of the vitamin D3 that we need comes from exposure to sunlight, which transforms a cholesterol metabolite (7-dehydrocholesterol) into the vitamin D precursor (vitamin D3 or cholecalciferol). This is what we absorb from naturally occurring fish oil and oily fish, but otherwise this does not naturally occur in foodstuffs (Ref. 1). Dr. Eisenstein pointed out that it is well known that people living north of the 37th degree latitude lack vitamin D3 because of a lack of sun exposure, particularly in the winter season. People south of the 37th degree latitude have enough sun exposure, but wherever you live, it is advisable to have your vitamin D3 level measured (as 25(OH)D level). If you do not eat enough fish or fish oil, the levels likely are too low as is the case for 2/3 of the US population. Vitamin D3 supplements will have to be taken by those whose levels are too low. Vitamin D3 is further metabolized by the liver and then by the kidneys into the active vitamin D compound, called 1,25(OH)2D3 (which is called “calcitriol”). The main effect of calcitriol is to absorb calcium and phosphate from the intestine into the blood stream. Together with vitamin K2 as explained in a prior blog these minerals are then taken up by the bone to prevent osteoporosis or rickets in the growing child. What has not been known for a long time is that vitamin D3 is also necessary for normal cell metabolism by most of your body cells, but particularly by the vital organs like the brain, the heart, the kidneys, the liver, the immune system and the bone. However, doses of 5000 IU to 10,000 IU of vitamin D3 capsules per day are required for optimal vitamin D3 health. This will lead to levels of below 200 ng/ml of 25(OH)D levels, which have been proven to be safe. According to Dr. Eisenstein no toxicity has been found below 30,000 IU of vitamin D3 per day, but based on other authors a dose of 10,000IU should be adequate for most people. Strangely enough colored people also have to take vitamin D3 supplements as their the higher melanin pigment in the skin filters out UV light so effectively that their 25(OH)D level can be low. Always err on the cautious side and have your vitamin D3 blood level taken.

Vitamin D3 has a characteristic stereotactic configuration (cis-triene structure), which allows it to bind free radicals and function as an antioxidant (Ref.2).

What are some of the clinical effects of vitamin D3?

1. Vitamin D3 has diverse effects on organs systems as Dr. Eisenstein summarized: vitamin D3 lifts depression and has been found to be of particular value for drug resistant depression. Take 5000 to 10,000 IU of vitamin D3 per day.

2. Muscle power increases with vitamin D3, particularly in those who work out regularly.

3. Many fertility clinics pay attention to vitamin D3 levels, as the higher the blood levels of vitamin D3 in a man, the faster this sperms move! And the more vitamin D3 she has on board, the better she ovulates. The end result is a higher pregnancy success rate when both partners take 5000 to 10,000 IU of vitamin D3 per day

4. Also, if a woman takes vitamin D3 during her pregnancy, the first set of teeth in the offspring will have fewer cavities.

5. Brain development in autistic children is much improved with vitamin D3 in higher doses. This needs to be combined with detoxification methods and supervised by one of the DAN physicians.

6.Chronic pain typically improves when vitamin D3 deficiency, which almost always is present in patients with chronic pain, is treated with vitamin D3 supplementation.

7. To prevent flus and colds and other infectious diseases, take higher doses of vitamin D3. When you come down with a flu, it is safe to increase your daily vitamin D3 intake to 30,000 IU of vitamin D3 for a few days until your symptoms improve, then resume your maintenance dose of 5000 IU to 10,000 IU per day.  This year’s dominant flu is the type A, subtype H1N1 – also known as the swine flu. Children should get 50% of the dose regimen detailed for adults when they develop a flu (for children: 15,000IU for three to five days , with tapering to a maintenance dose of 2500 to 5000 IU until blood levels of 25(OH)D are available). Here is a website of Dr. Cannell where he discusses dosages as well.

8. Asthmatic patients do better with vitamin D3 supplements requiring less maintenance anti-asthmatic medicine to keep them balanced with regard to their airways.

9. Chronic low vitamin D3 levels cause brain damage including Alzheimer’s disease. In this context it is important to know that the enzymatic conversion in the liver and kidneys slow down as we age requiring higher doses in older patients. This may have been the reason for the confusion about relatively low doses of 400 IU of vitamin D3 preventing rickets in children versus the need of vitamin D3 in middle aged and older patients where much higher doses are required as already explained.

10. High blood pressure is linked to vitamin D3 deficiency and it is better manageable with medication when vitamin D3 levels are normalized.

11. Live longer with vitamin D3. How is this possible, you might ask: the answer has been found in the telomeres, the shoelace like structures at the end of the DNA strand of each cell. Vitamin D3 lengthens the telomeres and promotes telomere repair; this is associated with a longer life span. Centenarians have longer telomeres. You can measure telomere length, but it is a pricey test, which is not for everyone, contrary to supplementation with vitamin D3 that should be taken by everyone!

12. As already indicated, vitamin D3 strengthens the immune system, but it also modulates the inflammatory response from muscle damage, so athletes can perform better. Patients with multiple sclerosis will improve as it slows down the inflammatory process. But other inflammatory diseases like arthritis, inflammatory bowel disease and even cancer will respond favorably to higher doses of vitamin D3 (20,000 to 30,000 IU of vitamin D3 in these cases). This is information that has not yet percolated into mainstream medicine, but will do so in the next few years (or decades?).

13. Higher percentages of cardiovascular disease are found in patients who have lower than 15 ng/ml  25-Hydroxy- vitamin D3 levels in their blood meaning that vitamin D3 supplementation prevents heart disease (Ref.3).

What are toxic vitamin D levels?

What is known about the safety of vitamin D3, particularly the higher vitamin D3 doses? First, it is wise to have your 25(OH)D blood levels taken from time to time. If any of these levels exceed 200 ng/ml it would be prudent to reduce the vitamin D dose or stop supplementation for a while. Otherwise it has been difficult to establish a toxic range.

This website claims that 40,000 IU of vitamin D3 or more would lead to toxic levels where the blood calcium levels would be increased, which can be measured as hypercalcemia. However, another study done in 2007 showed in MS patients that took 40,000 IU per day and that led to a blood level of 400 ng/ml of 25(OH)D did not lead to increased calcium levels and did not lead to hypercalciuria (too much calcium in the urine). So, all of the papers that either indicated to the public that it would be unsafe or unnecessary to take vitamin D3 seem to have other agendas than communicating the truth. Had it been true that calcium would be released from the bones or calcium were absorbed too much from the gut, this would have caused calcification of the bones, soft tissues, heart and kidneys. Also, kidney stones would have developed. However, a low calcium diet combined with corticosteroid drugs usually leads to a full recovery within a month. Interesting that all of the dire predictions regarding toxic vitamin D3 levels did not materialize. Here is another website discussing vitamin D3 dosing.

I talked to a participant of the conference (who has a fellowship degree of the A4M) about what is really known about vitamin D3 toxicity. He told me that there has been an unintentional overdose where a compounding pharmacy made a mistake, so that a patient accidentally received a dosage of 500,000 Units of vitamin D3 per day for a full three months, before the mistake was uncovered. The patient felt sluggish, but did not have any other symptoms. He was told to stop the vitamin D3 compound. He had an uneventful recovery with no detrimental effects. At this point no overdose of vitamin D3 has been established.

Conclusion

Vitamin D3 is a vital supplement that has been shown to prevent not only rickets in children, but also depression, MS, infections and even many cancers (Ref. 4). As usual there will be many critiques that doubt the validity of the above statements. But I have found that all of these effects described above were confirmed in several sources of various medical information. Keep in mind that negative rumours have a tendency to linger on for years.

More information on vitamin D3 for prevention of osteoporosis and hardening of arteries: http://www.askdrray.com/calcium-vitamin-d3-and-vitamin-k2-needed-for-bone-health/

Vitamin D3 deficiency can cause pancreatic cancer: http://nethealthbook.com/news/insufficient-vitamin-d3-linked-to-pancreatic-cancer/

References

1. McPherson: Henry’s Clinical Diagnosis and Management by Laboratory Methods, 22nd ed.,  © 2011 Saunders

2. Rheumatic Diseases Clinics of North America – Volume 38, Issue 1 (February 2012) , © 2012 W. B. Saunders Company

3. Wang TJ, Pencina MJ, Booth SL, et al:  Vitamin D deficiency and risk of  cardiovascular disease.   Circulation 117. (4): 503-511.2008.

4. “Recognition and Management of Vitamin D Deficiency”: American Family Physician – Volume 80, Issue 8 (October 2009),  © 2009 American Academy of Family Physicians

Last edited Nov. 7, 2014

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Jan
04
2014

Impressions From The 21st Annual World Congress On Anti-Aging Medicine (A4M) In Las Vegas

Every year in mid December Vegas hosts the world A4M conference (from the American Academy Of Anti-Aging Medicine). This year’s conference was at the Venetian/Palazzo Resort in Las Vegas, NV from December 13th to 15th, 2013.

There were more than 3,500 attendees who participated in this yearly continuing medical education event in preventive and integrative medicine. Over 50 speakers reviewed various anti-aging topics including aesthetic medicine and stem cell topics. In addition there was a huge exhibition with over 300 exhibiting companies of health related products and books.

I attended this conference to see what is new in anti-aging medicine, which is the focus of my interest since my retirement in 2010.

Here are some highlights the way I saw it. As the topics were varied, I simply present a potpourri of snippets, all of which have some usefulness.

1. Opening remarks by Dr. Ronald Klatz and Dr. Robert Goldman

Dr. Klatz pointed out that the A4M has been very active over the years in lobbying for making supplements more available to the public. In 1995 the A4M was defending melatonin as a harmless sleep aid and the FDA agreed to allow it to be freely sold in health food stores. In 1996 DHEA followed this trend. Because of pressure of the A4M on the FDA Co-Q10, an important cardio protective supplement became available in health food stores in 1998. In 1999 the A4M stated in a public statement that newer research has confirmed that insulin is involved in obesity and diabetes and is an important aging substance. Those who continue to have high fasting insulin levels, will age faster than the average population. But those who lose weight, and exercise will reduce fasting insulin and will no longer age prematurely. The reason for this is that inflammation is the cause of high blood pressure and of cardiovascular disease like heart attacks and strokes. Reduce or eliminate fasting insulin and you eliminate the risk for heart attacks and strokes. In 2004 the A4M announced that stem cells could be used as an important tool to treat various end stage diseases to allow people to live longer. Since then this has become a huge specialty area. There was also a separate pre-conference workshop on stem cells. In 2009 the A4M announced that vitamin D3 was effective beyond bone health. Every cell in the body contains vitamin D receptors. Originally the 400IU per day RDA dose was established to fight rickets. Now it is recognized that 4000 or 5000 IU of vitamin D3 are required every day for a multitude of normal body functions. People with the poorest lifestyles have the shortest life expectancy, 66.5 years in Native Americans of South Dakota; in contrast the longest life expectancy in the US is found in Asian American women in New Jersey with 91.8 years. It just so happens that in New Jersey most of the 26,000 A4M physicians are practicing, which may be one of the reasons for the impressive longevity figures.  Dr. Katz suggested that we should recommend the following website to people: http://www.worldhealth.net/  This is the official medical news website of the A4M and deals with the latest health recommendations.

Dr. Goldman added to this that the anti-aging industry is growing rapidly (0$ in 1991; 250 billion $ in 2012; an estimated 345 billion $ in 2018).

He also emphasized that anti-aging can only be achieved, if blood tests are done early to detect any hormone or chemical abnormalities in the beginning stages before permanent organ damage sets in. Only with early detection can effective anti-aging treatments be initiated. Prevention is always better than waiting for an emergency to occur and then wanting to fix it, as it is commonly done in the conventional medical system.

Impressions From The 21st Annual World Congress On Anti-Aging Medicine (A4M) In Las Vegas

Impressions From The 21st Annual World Congress On Anti-Aging Medicine (A4M) In Las Vegas

2. Hypertension diagnosis and treatment

Dr. Mark Houston (Nashville, TN) talked about new and revolutionary concepts in treating and diagnosing hypertension (high blood pressure). Endothelial and vascular muscle dysfunction are now in the center of the researchers’ attention. The reason for blood pressure to get elevated is from a combination of inflammation, oxidative stress and autoimmune dysfunction of the vascular system. Decades before the blood pressure shoots up, there are vascular and heart abnormalities. 24 hour ambulatory blood pressure monitoring (24hour ABM) is the most reliable test for assessing blood pressure.

Among other things a micronutrient test was suggested as this way a lack of magnesium could be detected. Too little magnesium in the blood has to be treated with magnesium citrate supplements.

In terms of treatment it was interesting to note that diuretics and beta-blockers are no longer recommended, because of serious side effects. Instead of these medications the treatment of choice now are calcium channel blockers (Diltiazem etc.) and angiotensin II receptor blockers (Losartan etc.):

3.  Testosterone therapy in men

This was the topic of Dr. Abraham Morgentaler, a professor of urology at Harvard Medical School. He asked whether it is a panacea, a scourge or the next big thing in medicine. He went through various literature citations that showed that there is no relationship between testosterone or DHT (de-hydro-testosterone) and prostate cancer. In a New England Journal of Medicine publication Dr. Morgentaler has shown by doing extensive prostate biopsies on men with or without prostate cancer that testosterone treatment did not cause prostate cancer or make prostate cancer worse. He found that testosterone treatment invariably made men feel better, and they had more energy using testosterone. They also lived longer. He also debunked a recent JAMA publication from November 2013 that stated testosterone replacement would have led to increased heart attacks. He explained that he called the editor after calculating the raw data and coming to the conclusion that the authors had miscalculated and misrepresented the data, as the risks of heart attacks in men using testosterone were actually half of what the controls without testosterone replacement showed. However, the editor elected to keep the false data in the publication, which has caused confusion with the public and with the medical profession. Here is another rebuttal by Dr. Trutt who came to the same conclusion. Fact is and this is in agreement with many other medical publications in the US, Europe and around the world that testosterone replacement (with bioidentical testosterone) in a testosterone deficient man will cut the risk for heart attacks and strokes into half of what it would be if he did not replace with testosterone. However, only bioidentical testosterone will show this heart and brain saving effect, as there is a key/lock mechanism between bioidentical testosterone and the testosterone receptors of heart and brain cells and the testosterone receptors in the arterial walls.

4. Keynote speaker

Suzanne Somers was the keynote speaker on the first day of the conference in a talk entitled “Our time has come”. Her books have greatly contributed to the popularity of the anti-aging movement in North America and around the world. She described how important it was for her to take charge of the health care in her own case and to explore alternatives to treat her breast cancer in the past. She allowed a lumpectomy, but she refused chemotherapy which conventional medicine wanted to force on her. Instead she changed her lifestyle completely as summarized in her books, particularly in “Breakthrough”. She also became one of the pioneers in the US to get the newly FDA approved mesenchymal stem cell/fat cell transplant done on the affected breast to restore the pre-surgical appearance. She made a plea to those who can afford it to bank their stem cells, which was later reiterated by Dr. Terry Grossman, MD whose lecture I did not review here. I noted this key sentence in Suzanne Somers’ speech towards the end: “I work prophylactically to take care of my health”. How often have I wished in the past that every one of my patients would have this attitude!

5. Hormone testing and nutrition

Jim LaValle, an adjunct professor in the College of Pharmacy, University of Cincinnati has more than 27 years of clinical experience in the field of natural therapeutics and functional medicine. He mentioned that many people are toxic from a leaky gut due to faulty nutrition, which in turn will lead to heart disease and kidney disease. Once a patient has heart failure, a leaky gut will make the heart failure worse. Leaky gut leads to multiple autoantibodies, which causes various autoimmune diseases. Another area he concentrated on in his talk is the fact that neuroplasticity in the brain can restore people’s brain after brain injuries or when autoimmune diseases have attacked the brain. Through lifestyle changes stem cells in the support tissue of the brain, called glia cells, can develop into neural progenitor cells, immature newborn granulocyte cells and eventually into mature nerve cells. In other words the same sequence that occurs in the embryo with brain maturation can also occur in adults. Researchers are only learning now how to approach this difficult subject. He pointed out that there has to be a balance between the gut, the brain and the immune system. As the gut is also an immune organ (Peyer’s patches) where Th1, Th2 and Th17 lymphocytes are produced, it is important to manage your gut through probiotics and through intake of organic foods to get away from anything that disbalances the gut/immune system/brain interaction. At the end he briefly touched on two important facts: zinc is a trace element that is important for prevention of a leaky gut as it keeps the cell bridges of the lining of the gut intact. However, when zinc levels are done on patients in the hospital setting, he found that patients are often deficient for zinc, but they are responding very rapidly to zinc supplementation. Stress, which causes high cortisol levels leads to lowered endurance, autoantibodies and allergies. By checking other hormones, which need to be in balance with cortisol the caregiver can recognize what is wrong with a patient and help restore the hormone balance with bioidentical hormones. This will also take care of the leaky gut, the autoimmune diseases and improve asthma in a person who has allergies.

6. Aging and the short telomere connection

William Andrews, PhD has worked in the biotech industry for 28 years and had obtained his Ph.D. in Molecular and Population Genetics at the University of Georgia in 1981. In the last 15 years he has focused on finding ways to extend the human lifespan by interfering with telomere shortening in human cells. He shared some interesting facts with the audience: reproductive cells do not age and their telomeres stay long. He said that in order to age gracefully it helps to know the length of your body’s telomeres. He recommended using the HT Q-Fish telomere test, which is a genetic test that gives an average of the telomere status of your body. This test will determine the %-age of short telomeres in the body, which is what is most informative about your biological age and your average life expectancy. There are several methods that are useful to know, which lengthen your telomeres: exercise, omega-3 fatty acid supplements, vitamin D3 in higher doses and not smoking are all known to lengthen your telomeres. Astragalus, a Chinese herb and extracts (expensive!) derived from this plant have also been shown to increase the length of telomeres. Other factors that help to preserve the length of your telomeres are reducing stress (yoga, meditation, enjoyable music), weight loss through a ketogenic diet, reduction of depression (rebalancing brain hormones), reducing pessimism, and being happy. Did you know that lobsters are blessed with ubiquitous telomerase expression? As a result they turn over 100 years. Humans are not so lucky, but we have access to simple steps that are protecting our telomeres! Dr. Andrews’ company has searched for telomere elongating substances. Through testing of 39 families of chemicals that are stimulating telomerase to elongate telomeres, he found a few that work. However, the main first step should be to concentrate on restoring the diet of our distant ancestors that gave us our genetic make-up. He stated that the Western diet is the worst contributing factor for telomere shortening. The macro and micronutrient difference between our ancestral diet and the modern diets have caused diseases like high blood pressure, heart attacks, stokes, obesity, diabetes, insulin resistance, dementia and cancer. Our modern diets (particularly the high carb/low fat diets) have increased oxidative stress in our bodies from increased reactive oxygen. This reduces our antioxidant reserves. It leads to malfunctioning of the endothelial lining. Other contributory factors are the overfeeding with omega-6 fatty acids from processed foods and cooking oils(such as corn oil and soybean oil and others.). These food infractions lead to a relative lack of the key vitamins A, D, E and K2 that are important to maintain cell function.

7. Telomeres, Aging and Disease

This title was the talk by Dr. Mark Rosenberg, who has been involved with drug research since 1991. This lecture reinforced what Dr. Andrews has said. However, he added a few aspects that are important to mention: “aging promotes aging”; in an aging person there are more circulating free radicals that undermine your health. So it is important, particularly for an older person to take anti-oxidant supplements to stop free radicals from aging you even faster. Dr. Rosenberg has done a lot of research with cancer cells. He noted that the circulation in a cancer or in metastases from cancer is very poor, which is the reason why chemotherapy often does not reach the cancer cells. He also found in the literature and in his own clinical experience that patients with low LDL cholesterol have increased cancer susceptibility. He mentioned that this was a new paradigm. I have recently discussed this in detail in a previous blog. Briefly, LDL cholesterol is the transport form of cholesterol going from the liver to vital organs like the heart or brain. When LDL is oxidized by free radicals from eating too much sugar and starchy foods that are metabolized into sugar, cells are starved of nutrients and oxygen. This sets the stage for cancer cells to develop, which have a metabolic advantage of being able to produce energy by glycolysis rather than by the aerobic metabolic pathway. Smoking and alcohol consumption shorten telomeres and this makes the person more prone to developing cancer.  On the other hand telomerase treatments have been shown to NOT cause cancer, which was a false belief in the past. At this point it is lifestyle changes that are needed to reduce the using up (aging) of telomeres. Resveratrol, vitamin D3, and astragalus all seem to contribute to lengthening of telomeres. The next few years will likely bring more news about this.

Conclusion

I have only been able to give a few highlights of the 21st Anti-aging Congress in Las Vegas. Another highlight was an appearance of Travis Stork, MD from the ER-doctor show on television. He gave a very down-to-earth presentation making 4 points: 1) healthy living starts in the kitchen, 2) “I need you to start working out”, 3) Mind and body are connected (stress can ruin your health) and 4) Get enough sleep (40% do not get enough sleep), because all of your hormone glands are recovering overnight. He concluded by saying: “Make health your hobby!” Another happening later in the conference was the appearance of California’s 38th Governor, Arnold Schwarzenegger. He received the highest honor of the A4M, the 2013 INFINITI AWARD for his leadership role of funding and supporting stem cell research in California.

Each A4M conference seems to have something new to offer every year. There were many other things that I learnt, but in my mind the topics I summarized above stood out from the rest.

More information on:

1. the use of testosterone and other hormones in male menopause:  http://nethealthbook.com/hormones/hypogonadism/secondary-hypogonadism/male-menopause/

2. high blood pressure: http://nethealthbook.com/cardiovascular-disease/high-blood-pressure-hypertension/

3. telomere lengthening by vitamins, minerals and supplements: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/vitamins-minerals-supplements/   In this review I am mentioning a large Chinese study that proved telomere  lengthening with vitamin C and E, but no other vitamins. Other vitamins are still needed as antioxidants to prevent cancer and hardening of arteries.

Last edited Nov. 7, 2014

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Dec
21
2013

Buying Into High Carb, Low Fat Myth Makes You Sick

If you are like most people, you probably still think that “healthy grains” like wheat are good for you and are “essential for a well balanced diet”. Ever since Kellogg’s introduced cereal for breakfast and the bagel was invented as a mid morning snack, which has captured the tastes of millions, the Agro Industry and the food industry have lobbied to have “healthy grains” in the food pyramid or on your plate. The very thought of “the daily bread” is deeply ingrained in our culture.

Other agencies like the Heart Foundation, the Academy of Nutrition and Dietetics (formerly “American Dietetic Association“) and the American Medical Association have reiterated this statement over and over until both the public and physicians accepted this as the truth. However, the scientific data does not support this point of view!  It has been a myth!

We are gradually learning that there has been a big misinformation campaign going on as far back as 1984 (and before) when a consensus panel came up with revised normal values for cholesterol and we as the medical profession were told (myself included) to treat high cholesterol levels much earlier and more aggressively than in the past with statins.

Big Pharma is still pushing for this. Now that I am retired for more than three years I can freely write about what is really going on. The truth has already leaked out, but it is not yet common knowledge.

I like to review the switch from the old school of thought that a high carb/low fat diet would be healthy to the new school of thought that a low carb/high healthy fat diet is healthy. Before you panic, sit back, relax and read what I am saying.

Buying into High Carb, Low Fat Myth Makes You Sick

Buying Into High Carb, Low Fat Myth Makes You Sick

A brief history of the high carb/low fat diet recommendation

It was the Framingham Study, which is an ongoing study since 1948 where a large group of people was followed for decades to sort out what causes heart attacks and strokes and how one could develop a program of prevention. This objective at the beginning of the study was very noble and promising. However, as time went on the results from the Framingham Study that were published intermittently appeared to be more and more confusing.

First there was the lipid theory that was based on the observation that high lipids (called triglycerides) and high cholesterol in the blood would cause heart attacks and strokes. It was assumed that it must have been the fats in the diet that would have caused this. Based on this thinking the lipid theory of arteriosclerosis was formulated, a theory trying to explain how heart attacks were caused.

If this theory were true, a lowering of the blood lipids and cholesterol should have lowered the rates of heart attacks and strokes. Many large trials were done and the statins were developed to lower cholesterol. In a recent blog I have explained that this has not lowered the mortality rates from heart attacks and strokes, but instead of admitting that the researchers made a mistake, many are still doggedly holding on to the dogma of the lipid theory. The truth is that the lipid theory has not been proven to be true; the recommendation of a high carb/low fat diet has also not worked out to save lives by preventing heart attacks and strokes. In fact the opposite is true: older people with high cholesterol live longer and have less Alzheimer’s disease than those with lower cholesterol levels in the blood as Ref. 1 has explained in detail. Dr. Perlmutter mentioned a study from the Netherlands (Ref. 1, page78) involving 724 individuals who on average were 89-year old that were followed for 10 years. Those with high cholesterol lived longer than those with low cholesterol, exactly the opposite of what the lipid theory predicted! Specifically, for each 39% increase in cholesterol there was a 15% decrease in risk of mortality. Think about it: the brain and the heart have LDL receptors on their cell surfaces for a reason. The reason is that both vital organs burn fat and need cholesterol to build up the membranes of the brain and heart cells.

Despite this compelling evidence Big Pharma is in denial and you will still find the lipid theory of arteriosclerosis heavily mentioned on the Internet as the only “valid” explanation for how heart attacks and strokes would be caused.

Inflammation as the alternative explanation of arteriosclerosis

Since the mid 1990’s the first reports surfaced to explain that about 50% of patients with normal cholesterol levels still develop heart attacks. In these patients the C-reactive protein, an inflammatory marker, was very high indicating that an inflammatory process likely caused their illness.

Subsequently further research was able to show that the LDL cholesterol, when oxidized by sugar was responsible for clogged arteries in these patients. It also became apparent that diabetics have a much higher risk to develop heart attacks than patients with normal blood sugars. This led to the conclusion by several different research teams that the lipid theory was wrong and needed to be abandoned.

Instead a new theory has developed that explains that heart attacks and strokes develop in patients where free radicals have damaged LDL cholesterol. This oxidizes LDL cholesterol and leads to hardening of the arteries (arteriosclerosis). Sugar from increased carbohydrate intake has a lot to do with this: it leads to glycation of protein causing glycation end products (abbreviated as AGE’s).

This is an appropriate name as it really is the cause of premature aging, of developing wrinkles, of getting premature hardening of arteries and having a 50-fold risk of free radical formation. This in turn will lead to more tissue aging. LDL used to be thought of as the “bad cholesterol” (I myself have used that term in the past). LDL is now known to be the friendly and important transport form of cholesterol, which is sent from the liver to the brain and heart cells that need it for their metabolism. If LDL is oxidized, however, it becomes useless and the heart and brain cannot absorb cholesterol for membrane synthesis via the LDL receptors. The end result is that vital organs like the heart and the brain do not get enough oxygen and nutrients, which leads to heart attacks and strokes. The free radicals that are released from oxidized LDL cholesterol and that circulate in the blood cause an inflammatory response in the lining of the arteries all over the body, which you know as hardening of the arteries (arteriosclerosis).

This may sound complicated, but all you need to remember is that sugar and starch consumption lead to accelerated hardening of arteries in your body, which causes heart attacks and strokes.

Reassessment of what a heart healthy, brain friendly diet is

The above-mentioned research findings require a complete re-thinking of what a healthy diet would be. The villain turned out to NOT be saturated fat (meat, eggs, butter and avocado), but rather TRANS fat (margarine, hydrogenated polyunsaturated fatty acids) and I agree with the FDA that this should be abolished.  Trans fat is full of free radicals oxidizing LDL cholesterol, which we just learnt is causing hardening of arteries. It is sugar and starches that turned out to be the main villain. Omega-6 fatty acids, found in safflower oil, sun flower oil, grape seed oil and canola oil are bad for you also as they lead to inflammation through the arachidonic acid system in the body. Conversely flaxseed oil, omega-3 fatty acids (EPA and DHA) derived from fish oil are very protective (anti-inflammatory) oils, as is olive oil and coconut oil. These latter two are anti-inflammatory monounsaturated fatty acids. Keep in mind that you want to change the ratio of omega-3 to omega-6 fatty acids more in the direction of omega-3 fatty acids, so that the ratio will be between 1:1 and 1:3. Most Americans are exposed to ratios of 1:8 to 1:16 (too many omega-6 fatty acids in fast food and processed foods), which leads to inflammation of the arteries as well.

The new “heart and brain healthy diet” consists of no refined carbohydrates (sugar and starch), but about 45% complex carbohydrates (organic vegetables like broccoli, spinach, cauliflower, Brussels sprouts, peppers, onions, garlic, peppers, Swiss chard, zucchini, asparagus etc.), 20 % protein and 35% saturated and other fats like omega-3 (1:3 mix with omega-6) fatty acids and monounsaturated fats (like olive oil or coconut oil).

According to Ref.1 you can even eat butter, lard and other animal fats provided they come from clean (not antibiotic or bovine growth hormone treated) animals. Dr. Perlmutter (Ref.1) points out that even extreme diets like the Inuit diet with 80% saturated fat and 20% protein leads to longevity with healthy arteries. The patients who died in the many trials including the Framingham Study did so, because of free radicals from sugar, starch and wheat. Wheat contains the addictive gliadin molecule (part of gluten), which makes people eat more sweets and starchy foods. The liver turns the extra calories into visceral fat deposits that in turn cause the release of cytokines like tumor necrosis factor alpha (TNF alpha) and COX-2 enzymes.

This causes inflammation, heart attacks, strokes and cancer.

Contrary to what Big Pharma wants you to know cholesterol is an anti-inflammatory, LDL is a cholesterol transporter (provided it is not oxidized) and HDL is protective of hardening of the arteries as long as the “ratio of total cholesterol to HDL cholesterol” is less than 3.4 for males and 3.3 for females. This is the cholesterol risk ratio used by cardiologists to determine the risk of coronary artery disease. The average risk of this ratio for Americans is 5.0 for males and 4.4 for females. The ideal ratio to strive for is the “1/2 average risk” ratio of 3.4 for males and 3.3 for women (Ref.2).

Paradigm shift in causation of heart attacks and strokes, but also of cancer, and neurological diseases

As pointed out in Ref. 1 there has been a paradigm shift in our thinking about what causes inflammation and what causes all of the major diseases including premature aging. Many physicians are not up to date in this new thinking although it has been in the medical literature since about 1995. In my colleagues’ defense I like to say that they are busy people and they do not always have the time to do their continuing education. However, it is imperative that the public learns about this paradigm shift as it affects literally everyone. In my YouTube video on the home page of www.nethealthbook.com I have talked about this new thinking in the summer of 2012. Now we are learning that there is an anti-inflammatory, cholesterol containing, fat rich diet without refined carbs, but containing ample complex carbs, which is a modified zone diet or a modified Mediterranean diet that will prevent all these diseases. At the same time it is a weight loss diet as cholesterol and fat in your diet stops the liver from producing lipids and triglycerides and helps you to lose weight. Critics will say that it sounds too good to be true, but I agree with Dr. Perlmutter and Dr. Davis, both of whom have provided ample evidence that it is true. Try some of their recipes. Just read Ref. 1 and 2, where recipes are listed in the back part of their books. Or try the recipes I listed for one day in this blog. I am publishing a book entitled “A Survivor’s Guide To Successful Aging” through Amazon.com, which will come out later in early 2014 where you can find recipes for 1 week in the last chapter.

Conclusion

There has been a paradigm shift in the thinking of how hardening of the arteries is caused. Now it is known that an inflammatory process causes it. It is an overindulgence in sugar, starch and wheat products that causes the liver to produce lipids, cholesterol and leads to the “wheat belly” and the “grain brain”. All of this causes cytokines to bring about an inflammatory reaction that affects the lining of arteries causing heart attacks, strokes, but also Parkinson’s disease, MS, autism, asthma, arthritis, epilepsy, Lou Gehrig disease and Alzheimer’s disease (Ref.1). The inflammation does not stop there. If you keep up the high carb/low fat diet, it will lead to various cancers (Ref. 1 and 3). The solution is a diet high in healthy fats (I would call it a low carb/medium high healthy fat diet) as outlined above consisting of 30 to 35% healthy fat, 20% of protein and 45 to 50% of complex carbs, but none of the refined carbs. I have followed such a diet since 2001. I am enjoying that I can now eat  a reasonable amount of healthy fats, which I was not aware of being allowed before I read Ref. 1 and 3, but I continue with the antioxidant vitamins and anti-inflammatory supplements to prevent LDL oxidization. I hope that many of you can benefit from prevention so you can enjoy a healthy life without being a victim of illness or disability.

More information on:

1. arteriosclerosis: http://nethealthbook.com/cardiovascular-disease/heart-disease/atherosclerosis-the-missing-link-between-strokes-and-heart-attacks/

2. paradigm shift regarding hardening of the arteries: My book “A Survivor’s Guide To Successful Aging: With recipes for 1 week provided by Christina Schilling” explains the content of this blog in much more detail.

References

1. David Perlmutter, MD: “Grain Brain. The Surprising Truth About Wheat, Carbs, And Sugar-Your Brain’s Silent Killers.” Little, Brown and Company, New York, 2013.

2. Life Extension: Disease Prevention and Treatment, Fifth edition. 130 Evidence-Based Protocols to Combat the Diseases of Aging. © 2013

3. William Davis, MD: “Wheat Belly Cookbook. 150 Recipes to Help You Lose the Wheat, Lose the Weight, and Find Your Path Back to Health”. HarperCollins Publishers LTD., Toronto, Canada, 2012.

Last edited Nov. 7, 2014

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Aug
31
2013

Peanut Allergies Are Deadly

In the US 1.5 million suffer from peanut allergies (Ref.1). People who have peanut allergies have to avoid peanuts and foods that contain even traces of peanuts lifelong. Here is a recent example of a 13-year old girl who died at a camp when she tried food contaminated with peanuts. Before we discuss peanut allergies in detail, we need to review first how the immune system is functioning.

How the immune system is primed to develop an allergy

Our immune system knows the difference between our own body components and substances that come from the outside. Scientists call this tolerance to our own surface proteins; and scientists call it an immune reaction that is mounting as a reaction to anything different from the surface antigens. There are different cells that make up the immune system. One of the main working cells of the immune system are the lymphocytes, with B cells originating from the bone marrow producing antibodies when an immune reaction occurs. Antibodies fit like a lock and key to the surface of an antigen, in this case the peanut protein. T helper cells are T lymphocytes (thymus derived lymphocytes) that help the B cells to recognize the difference between the own protein components and the outside components. There are also T killer cells, which get activated when parasites or viruses enter the body. With regard to peanut allergies it is the B cells and T helper cells that interact and the B cells produce a powerful, very specific IgE antibody directed against peanut protein. There are memory B cells, which continue to produce these specific anti-peanut protein antibodies and cause severe allergic reactions when future exposure to peanuts (even traces) occurs. So, the more often a person who is allergic to peanuts encounters even traces of peanuts, the immune system will get boosted and produce even more antibodies of the IgE type through reactivated B memory cells (Ref. 2). 98% of the population does not react to peanut exposure with allergies, but the other 2% who may have genetic susceptibility factors that predispose them to this often develop life-threatening reactions (an anaphylactic reaction).

What is an anaphylactic reaction to peanuts?

The most extreme form of allergies involving IgE antibodies can cause anaphylaxis. In the beginning stages of a peanut allergy there may only mild symptoms such as hives on the skin, itching and tingling around the mouth, a runny nose, a scratchy throat, wheezing, stomach cramps, vomiting or diarrhea. However, with a more severe allergy an asthma attack can develop, blood pressure drops leading to fainting or shock and severe airway obstruction in the throat or lungs can cause suffocation.

I vividly remember an 11-year-old boy who was brought in by ambulance to the emergency room of the hospital where I was working as the on-call physician. He had a hard time talking as his throat was swelling up as part of his anaphylactic reaction, within minutes he passed out completely (shock). Fortunately an anesthetist was in the department and could intubate him very quickly. However, despite adrenaline treatment, oxygen  by artificial ventilation and high doses of corticosteroid drugs he did not wake up until 10 hours later. In retrospect it turned out that he had eaten some crackers of a familiar brand that he knew as being free of peanut flour. However, he had seen an ad that the same brand of crackers was available as cheese crackers and he tried one of these, which prompted his admission to the hospital. The parents read the ingredients later: the label on the cheese crackers noted in small print that the flour of the cheese crackers contained peanut flour! Always read labels, even if it is a familiar brand! Fortunately for this boy he did not have brain damage from the time of his unconsciousness. He has been extremely careful since and is reading labels and avoiding unknown food items.

Peanut Allergies Are Deadly

Peanut Allergies Are Deadly

Cross-reactions between peanuts and other allergens

Allergies can be made worse when a person has inhalant allergies from pollens of trees or grasses that can share protein components from protein found in foods. The latest findings are that there are cross allergies between Fenugreek and lupine, which are both legumes, as are peanuts, so there are common antigens present in their proteins. A mouse-testing model has shed more light on this. Fenugreek has been shown to control mild diabetes by improving insulin resistance, but it cannot be consumed by persons who are highly allergic to peanuts because of the cross allergy mentioned.

There are other possible cross allergies to legumes like lentils, soy and chickpeas.

Other factors that can cause allergies to get worse

In the past the RAST test was often used.  This is a blood test for common food allergies that can cause severe allergic reactions like egg, milk, peanut, tree nuts, wheat, crustacean shellfish and soy. However, since about 2010 this has been replaced by the more sensitive ImmunoCAP Specific IgE test. Children who have food allergies to egg, milk, wheat, nuts, peanuts and soy often outgrow these allergies when they age, in other words their immune system can develop tolerance to many of these foods. Not so with peanut allergies ! They tend to be very persistent.

The immune responses to food allergies are complicated as there are immediate type immune reactions and delayed type immune reactions. The immediate immune responses are investigated with the above mentioned ImmunoCAP Specific IgE test. The delayed immune responses can be measured using the ELISA test. Positive IgE antibody tests for peanut protein are a marker that the person affected likely has more other allergies and they should be investigated by a knowledgeable allergist in that regard (Ref. 2).

What complicates the allergy sufferers’ lives even more is the fact that new wheat varieties since the 1970’s, called Clearfield wheat have a much higher gliadin (gluten) and lectin content than the old wheat varieties. As a result of exposure to this new type of wheat gluten intolerance and leaky gut syndrome have increased substantially in the world population (Ref.3). In addition, genetically modified foods like soy, corn, sugar beets, canola and others have challenged the immune system of sensitive humans even more. We do know that some people can develop autoimmune diseases from GMO foods and modern wheat, and this may be the reason that a host of diseases that belong into this disease category (MS, rheumatoid arthritis, Hashimoto’s thyroiditis, ankylosing spondylitis etc.) are much more common now than in the past. The geneticists who developed GMO foods seemed to be unaware how sensitive the immune system is, which will detect a few different amino acid sequences in a protein mounting a strong immune response to it.

Treatment for peanut allergies

The key for sufferers from peanut allergies is to avoid exposure to it. Read labels and use common sense. If something is not labeled, do not be tempted to eat it. Peanut flour is often mixed into the dough of crackers, not being labeled properly or only in fine print. With peanuts the antibodies usually circulate in the blood life long as the B memory cells do not diminish and get reactivated very quickly on repeat exposure producing antibodies again. As exposure to peanuts can cause severe asthma or anaphylactic shock, it is important to carry an EpiPen with you and to know how to use it.

In Europe attempts have been made to develop an oral desensitization method for food allergies including peanut allergies, but it has not produced concrete results yet. Recently, however, research from Texas, USA showed that it is possible to desensitize patients with peanut allergy by oral desensitization. In Australia where food allergies are more prevalent than in the US, tolerance to peanut, nut and shellfish allergies is being pursued by oral immunotherapy. Another group in Australia has developed a vaccination method using peptides, which are a sequence of amino acids, but shorter than the full peanut protein. It appears that this is the future direction of  treatment for peanut and other IgE mediated allergies: a kind of vaccination treatment to induce competing antibodies, which will neutralize the allergic IgE antibodies.

Conclusion

Peanut allergies have become more troublesome as the food industry has mixed peanut flour into Thai sauces, drinks, cookies, crackers and such. The person allergic to peanuts must read food labels and eat as much single-ingredient natural food as possible. This goes against the tendency of food processors who produce foods with a long rat tale of ingredients. If you see a label “may contain nuts or peanuts”, stay away from this product, as it is safer. Always carry an EpiPen or Twinject with you, just in case you develop an anaphylactic reaction (you only have a few minutes to stop the allergic reaction with adrenaline). In the future vaccination with a peanut protein specific peptide vaccine as mentioned regarding the Australian research, will probably become the treatment of choice.

More information on status asthmaticus (an acute asthma attack): http://nethealthbook.com/lung-disease/asthma-introduction/asthma-treatment/

References

1. Adkinson: Middleton’s Allergy: Principles and Practice, 7th ed. Chapter: Food Allergy. © 2008 Mosby.

2. Mandell: Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases, 7th ed.© 2009 Churchill Livingstone.

3. William Davis, MD: “Wheat Belly Cookbook. 150 Recipes to Help You Lose the Wheat, Lose the Weight, and Find Your Path Back to Health”. HarperCollins Publishers LTD., Toronto, Canada, 2012.

Last edited Nov. 7, 2014

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Aug
03
2013

Treating Symptoms Not Effective, Find And Eradicate Causes

When you see a physician about a health problem, he or she general listens to your symptoms, examines you, comes to a diagnosis and then treats the symptoms. Medicine has been evolving since, anti-aging medicine has become more prominent and comprehensive medical practitioners have started to treat differently. The changing approach is best explained with some examples below. This is important as many general practitioners continue to treat symptoms and neglect to search for causes. Big Pharma is trying to keep the medical system in the “status quo” (the way it is), because they make big money by having general practitioners try out different ineffective medications (this way the profits keep on coming in.) One example is the cholesterol story. Only 50% of heart attacks are caused by high cholesterol, but physicians keep on prescribing statins whenever high cholesterol is found to prevent a heart attack. But the finding of high cholesterol could be caused by hypothyroidism (when the thyroid gland does not produce enough thyroid hormone). Diet can also play  a role, if the patient eats too many helpings of fatty meats and drinks alcohol regularly. Just prescribing statins to lower cholesterol is not the answer, treating the cause is!

I am going to describe 5 examples where usually symptoms are being treated instead of the causes. If you are in a hurry, just read example 3 below (gastritis and duodenal ulcer). After that you can skip forward and read the conclusion, where I will summarize what I think we should learn from this.

Treating Symptoms Not Effective, Find And Eradicate Causes

Treating Symptoms Not Effective, Find And Eradicate Causes

1)  Rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disease where autoantibodies attack the joint surfaces. It is a multifaceted disease and typically requires a rheumatologist to get involved in the treatment. The standard treatment for RA is summarized in this link. Before engaging in these toxic treatments, it is very worthwhile to study this link and see, if any of your food components may have triggered your arthritis. Various agents in the food can contribute to the development of autoantibodies, such as wheat, soy, MSG, even salicylates. An elimination diet approach could pinpoint if there is any food component that may be the cause of your RA.

Dr.Lichten, in treating many RA cases has found (Ref.1, p. 85 and 86) that many patients had hormonal deficiencies, particularly a lack of DHEA when blood tests were done for this. DHEA is known to treat immune deficiencies and T cell responses were observed to raise 10-fold after DHEA supplementation; IGF-1 levels (an indirect measure of human growth hormone) increased and muscle mass improved when exercised as well along with DHEA replacement. RA patients responded well to relatively low doses of DHEA (25 mg daily for women and 50 mg daily for males). When other hormone tests are done to look for deficiencies, Dr. Lichten found sometimes thyroid deficiencies requiring hormone supplementation. Similarly when saliva tests are done to look for sex hormone deficiencies, there may be progesterone and/or estrogen deficiency in women and testosterone deficiency in males that needs to be replaced with bioidentical hormones. In RA patients there may be adrenal gland deficiency setting in, which can be diagnosed by a four-point saliva cortisol hormone test. Only these cases of true hormone deficiency will benefit from small doses of cortisol (the original bioidentical human hormone) given four times per day.

Here is a summary of the usual recommendations for home remedies for treating rheumatoid arthritis. Using electro acupuncture can be very useful for controlling chronic pain, but you still need to work out the cause for your particular case of RA.

2) High Blood Pressure

Most cases of high blood pressure (hypertension) are simply there without a particular cause. It used to be called “essential hypertension”, a fancy name meaning “essentially, we do not know the cause”. The doctor will start treatment with drugs to bring high blood pressure down. Before that the doctor is supposed to ask you to make a good effort to change your life style (cutting out additional salt, exercising, weight loss), but this is often glossed over and drugs are used right away. Drugs for hypertension are not harmless; here are some of the side effects.

The medical textbooks are not very clear on what causes high blood pressure. With renal causes (narrowing of a renal artery) a stent can be placed, the cause is treated and the blood pressure normalizes. As indicated, essential hypertension is the name for the majority of other cases of high blood pressure where officially no cause is known. Patients are usually put on life-long antihypertensive medications, often several drugs in combination, to bring the blood pressure down to 120 over 80.

Despite the notion that we do no know the cause of high blood pressure, we do know that a number of factors can contribute to developing high blood pressure: too much salt in the diet, too much nicotine from smoking and too much alcohol consumption.

A lack of nitrates from green vegetables can cause high blood pressure as well. Nitrates are necessary for the body to produce nitric oxide, a powerful messenger that dilates blood vessels lowering blood pressure. It is produced every second by the lining inside the walls of your arteries. Greens and vegetables, particularly beets, provide nitrates for nitric oxide production.

Nitric oxide, along with omega-3-fatty acid and prostaglandins are important in relaxing the arterial walls, thus lowering high blood pressure.

We also know that in diabetes and obesity high blood pressure is very common, because inflammatory substances circulate in the blood, which interfere with the normal production of the blood pressure lowering nitric oxide.

Treating high blood pressure with the conventional drugs will mask the real underlying causes.

The DASH diet has helped a lot of people to get their blood pressure under control. However, the limiting point in that diet is the amount of grains that are allowed. In my opinion, wheat and grains, starches and sugar are all empty calories and only stimulate your appetite because of the high leptin and gliadin content from wheat and wheat products. According to the cardiologist, Dr. William Davis, cutting these out will cure not only many cases of hypertension, but also diabetes and obesity. Many physicians have criticized him, but in my opinion his work is on solid researched ground. If a patient honestly gives lifestyle changes a try, many side effects and deaths from antihypertensive drugs could be avoided.

3) Gastritis and duodenal ulcer

You see your doctor, because lately you regurgitate acidy stomach contents. You may be diagnosed with gastritis and get a prescription for an acid suppressive drug. But before you take proton pump inhibitors (PPI) study the side effects here.

The interesting part is that many chronic gastritis cases are associated with a bacterium called H. pylori. Unfortunately it is now known that cimetidine, ranitidine and particularly PPI’s are treating the acid problem (the symptomatic treatment of acid suppression seems to work), but on the longer term they encourage H. pylori to grow more, particularly in the stomach. The bacterium undermines the lining of the stomach and the duodenum and interferes with the production of the protective mucous production, which is meant to protect you from gastritis and ulcers. Dr. Murray explains that the cause of gastritis, gastric ulcer and duodenal ulcer is the breakdown of the mucosal barrier (Ref. 3, p.73-75). So the symptomatic treatment of the H. pylori infection with triple therapy (2 antibiotics and a PPI) may be the medical treatment commonly accepted as the norm, but it does not cure H. pylori in many cases. Some patients develop diarrhea from a Clostridium difficile super infection as a result of the antibiotics from the triple therapy requiring even more expensive antibiotics for that condition. This only happened, because the patients’ symptoms were treated instead of the cause. The cause of gastritis and duodenal ulcers is a weakening of the lining in the stomach and the duodenum resulting in a breakdown of the mucous barrier. In some people dietary habits play a role, like too much cereal and wheat consumption with too little alkaline vegetables in the meals to neutralize the acid formation (see Ref. 2 for more details). However, when a simple licorice compound (DGL, which stands for deglycyrrhizinated licorice) is given, the symptoms from gastritis, acid reflux, and ulcers in the stomach or duodenum disappear. DGL supports the lining of the stomach and duodenum and reestablishes the defense against the acidy milieu. Not only that, but after a few weeks of DGL treatment all of the findings on endoscopy such as inflammation and ulcerations disappeared. Dr. Murray states that he has not encountered a case of gastritis or ulcer that would not have responded. It appears that the cause of gastritis and ulcers in the stomach and duodenum is not from too much acid, not from H. pylori infection, which appears to just be a concomitant infection, but actually is due to a breakdown of the barrier in the lining of the stomach and duodenum, which responds to DGL. The other interesting thing is that you can buy DGL in the health food store; the dosage is two to three chewable tablets on an empty stomach three times per day. According to Ref. 3 it needs to be taken 8 to 16 weeks, after which there is a full therapeutic response. Pepto-Bismol is another coating substance that is available over the counter and works well for minor stomach upsets.

4) Chronic back pains and insomnia

Many people see their chiropractor for chronic recurrent back pains and their physician for insomnia to get sleeping pills. It all depends what the underlying causes are of back pains and insomnia.

If there is a misalignment in the spine, a chiropractor doing manipulation would be a reasonable approach and the back pain symptoms often disappear. However, thyroid deficiency or adrenal gland insufficiency or adrenal gland fatigue may be the cause of back pains and muscle cramps. Unless the underlying cause is treated (in the case of hypothyroidism treatment with thyroid hormones), the back pains will stay. In fibromyalgia where muscle pains are all over the body, the standard treatment with antidepressants and pain pills just will not do it on the long-term. These patients require a detailed work-up with analysis of the hormonal status. Often they are suffering from a lack of thyroid hormones, a lack of sex hormones (in women a lack of estrogen and progesterone, in men a lack of DHEA and/or testosterone). But they may also have weak adrenal glands and a lack of growth hormone. An anti-aging physician (A4M) can order the appropriate tests and treat the underlying causes.

Fibromyalgia patients often have insomnia (sleep disorders). Dr. Lichten (Ref.4) recommends GABA in small doses (125mg to 250 mg) at bedtime along with 500 mg of L-tryptophan. He also recommends 4000 IU – 5000 IU of vitamin D3 (as often insomnia patients are deficient in vitamin D3) as well as 500 mg to 1000 mg of magnesium. If this alone is not sufficient, melatonin, 1 mg to 3 mg at bedtime will be beneficial. Dr. Lichten cautions that GABA leads to tolerance quickly, so it should only be taken 5 days out of 7 to allow the body’s receptors to recover. This alternative approach to treating insomnia will prevent many patients from getting addicted to sleeping pills (hypnotics).

5) Asthma symptoms

Not every case of asthma needs steroid inhalers and salbutamol or other bronchodilator inhalers as treatment. This link shows that low thyroid can also cause asthmatic symptoms of wheezing and shortness of breath. It is important to listen to the patient’s symptoms, but the treatment will only be successful when the cause is treated. Dr. David Derry described in this link how many of his severe asthma patients had iodine deficiency and low thyroid hormones and no longer had to see him when iodine treatment and desiccated thyroid hormone replacement was given as treatment. This goes against what the standard recommendation for asthma treatment is, but it seems to get patients unhooked from dependence on steroid inhalers.

Steroid dependency from anti-asthmatic inhalers can suppress the adrenal glands and lead to adrenal gland insufficiency.

The adrenal glands are vital for coping with stress as the more stress you are under, the more your pituitary gland produces ACTH hormone, which in turn stimulates the adrenal glands to produce cortisol. However, a significant percentage of patients with asthma that been on corticosteroid inhalers for a long time, experience a suppression of the pituitary gland and the adrenal glands cannot produce the required stress hormones; in other words, adrenal fatigue or adrenal insufficiency can set in.

This is an example where during the treatment of asthma symptoms were controlled with corticosteroid inhalers, but the stress hormone circuit was undermined to the point where the patient experienced another disease (called a “iatrogenic disease”, a disease from the side-effects of drugs). Treatment of adrenal fatigue is described in this link.

Conclusion

Medicine can become quite complex as these examples show. Many times physicians tell their patients that the cause of their symptoms is not known. However, this is not always true, but conventional medicine continues to hold onto the old dogmas. With the third example above (gastritis and duodenal ulcer), until the mid 1980’s the original theory in medicine was that too much acid production would be the cause of these conditions and treatment concentrated on suppressing acid production. Then the new theory came up that H. pylori, a bacterium would be the cause of chronic inflammation, which together with too much acid would cause the condition. That is why physicians now treat it with the triple therapy, a good deal for Big Pharma, but a bad deal for many patients. They still do not get cured, but develop a worsening of their conditions as H. pylori growth proliferates, particularly from the PPI’s, which undermines the lining of the whole stomach. As pointed out above DGL, a simple licorice compound, which is available in health food stores, can strengthen the lining of the stomach and duodenum, which at the same time gets rid of the H. pylori problem without any other drugs.

The problem with conventional medicine is that in many cases physicians still treat symptoms instead of treating known causes. Big Pharma supports this, as it is expedient for them to protect their multi billion-dollar industry. Patients need to demand that the causes of their diseases are being treated rather than the symptoms.

References

1. Dr. Edward M. Lichten: Textbook of bio-identical hormones. ©2007 Foundation for Anti-Aging Research, Birmingham, Michigan, USA

2. William Davis, MD: “Wheat belly. Lose the wheat, lose the weight, and find your path back to health.” HarperCollins Publishers Ltd., 2011.

3. Michael T. Murray, ND: “What the drug companies won’t tell you and your doctor doesn’t know”. Atria Books, New York, 2009.

4. Dr. Edward M. Lichten: Textbook of bio-identical hormones. ©2007 Foundation for Anti-Aging Research, Birmingham, Michigan, USA

Last edited Aug. 3, 2013

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Jun
01
2013

Toxins In The Bathroom

In the past I never looked at labels on shower gel, hair conditioner or liquid soap. But one day I read that the cosmetic industry uses parabens as a disinfectant in many body care products including cosmetics. That’s when I found out about my major supply of hair care products contained various parabens, like methylparaben, ethylparaben, propylparaben, butylparaben or heptylparaben.

Hair care and body care products

Officially, toxicity tests have shown that these substances are safe on the short term. What this means is that in short term experiments (usually up to 90 days) rats did not die from exposure to them. But long-term studies to see whether they would die from cancer have never been done. However, long-term exposure can lead to skin rashes in sensitive individuals (contact dermatitis, rosacea). This is still fairly harmless. Much more concerning are the effects of long-term exposure, which is what happens when we apply these chemicals to our skin every day. It has been shown that breast cancer specimens (what the surgeon cuts out during surgery) contain parabens, which can be measured in the lab. Further experiments have shown that parabens have estrogen-like hormone activity in animals and humans. They belong into the group of “xenoestrogens”. What this means is that they act like weak estrogens, and this can be cancer causing. In women estrogens are in balance with progesterone, but when parabens or other xenoestrogens are introduced, the estrogens get the upper hand, which can cause breast cancer and uterine cancer. In men where traces of estrogen and progesterone are also present, balanced with the more dominant testosterone, this hormone balance gets disturbed by parabens, and prostate cancer can develop. Why don’t we hear about this more often? Because it is a slow process that may take 20 to 30 years. By that time nobody thinks that breast cancer or prostate cancer could be the result of long-term exposure to parabens. For years the cosmetic industry argued that parabens would be just applied to the skin, not taken internally and for this reason they should be safe. The problem in this sentence is the word “should”. Parabens are absorbed through the skin and enter the bloodstream directly exerting the xenoestrogenic effect. Some  parabens occur naturally in very small amounts such as in barley, strawberries, currants, vanilla, carrots, and onions, but they are absorbed by the gut and get  destroyed by the liver in the so-called “first pass effect”. I went to the health food store and studied labels. I was able to get clean products (shampoo, conditioner, body wash), which do not contain parabens.

Toxins In The Bathroom

Toxins In The Bathroom

Tooth paste

This is a topic, which may get your dentist annoyed. Here are the ingredients to watch for:

1. What most people expect to be in a toothpaste is fluoride. The dentist was told by the representative of the toothpaste company that fluoride would make the enamel of teeth more resistant against tooth decay. This is passed on to the consumer. What is not passed on to you is that fact of fluoride toxicity, which occurs when fluoride gets absorbed into the body. This is called “skeletal fluorosis”.  Stomach and bowel irritation including irritable bowel syndrome and joint pains are part of this syndrome. In growing children the enamel of teeth can get discolored, the bone of adults can get brittle causing wrist fractures. Fluoride displaces magnesium on a cellular level and this causes metabolic problems in the kidneys and brain as many enzymatic reaction need magnesium as a co-factor. The thyroid can also become hypothyroid, particularly, if iodine was low to start with (fluoride can replace iodine in the body). If you feel you need to brush your teeth once per day with a fluoridated toothpaste, use regular, non-fluoridated toothpaste in between. You can also protect your body by taking iodine capsules twice per day to saturate your system with healthy iodine, which makes you more resistant to bromide, chlorine and fluoride toxicity.

2. Another ingredient on the label is often Sodium lauryl sulfate: this chemical is used to improve the texture of the toothpaste and make it foam up when you brush your teeth. The side effects are irritation of the mucous membranes, may cause canker sores, redness and irritation of the skin around the mouth. It is interesting to note that it also causes fish to die when the wastewater enters the ocean or water streams.

3.  Triclosan: This substance has antibacterial and antifungal properties and as such lends itself to prolong the shelf life of bodycare products (see this review). It is frequently used in deodorants,toothpaste and mouth washes. It is being investigated for safety by the FDA because it is an endocrine disruptor in animals and in humans, can cause hay fever, antibiotic resistance and can combine with chlorine from chlorinated water to cause release of chloroform, which is a known cancer causing substance. Many manufacturers have voluntarily abandoned the use of it.

4. Saccharin and aspartame: These artificial sweeteners are often used in toothpaste to add sweetness. Although originally thought to cause bladder cancer, saccharine has been cleared of this around 2000 when it was shown that although causing bladder cancer in rats, it was safe in humans. Diabetics have used saccharine safely for over 50 years. Aspartame, however, is more problematical:  there was an intensive investigation by the FDA whether or not aspartame would cause cancer in humans. As this review shows there were methodological flaws in some of the cancer studies so that the FDA finally decided to keep the previous recommendations that is was safe to use in diet drinks etc. the same. Other researchers disagreed and came to the conclusion that there were interest groups that interfered with the science of investigating safety of aspartame. Aspartame belongs into the group of excitotoxins, substances that can excite the brain and can also cause an existing cancer to metastasize. At this point in time it is much safer to cut out all aspartame from your diet including your toothpaste.

5. FD&C blue dye No. 2. This blue food coloring agent has been around as food additive since 1906. It was FDA approved back then. However, because of renewed health concerns this food coloring was re-reviewed. According to this reference the time exposure in animal experiments was not long enough (page 13 to 19 of this link), but serious complications such as significant brain tumors in rats and borderline higher frequency of bladder tumors and breast cancer were noted. The FDA elected to keep it listed as a safe food coloring agent. Hyperactivity in children is another observation that is of concern to parents. It simply is not worth to use blue, number 2 in toothpaste. Read your labels and leave it out!

Hair dyes

With the baby boomers turning grey as they get older, there is an interest in hair coloring. But of course people of any age group may like to change hair color and experiment!  Study labels of different products. You will notice in quite a few of them the familiar parabens as a disinfectant. Other toxins are ammonia, benzene, PPD (p-Phenylenediamine), toluene, coal tar. You find details of these ingredients and their side effects in this link (note a lot have been shown to be cancer producing). The bottom line is: avoid cancer-producing chemicals like the ones just listed. Instead buy your permanent herbal hair color in the health food store or health food section.

Cosmetics

Women probably apply too many creams and lotions on their skin. Cleansers, moisturizers, foundation, powder, eye shadow, lip stick, eye shadow, eye liner, nail polish are all substances that will be in part absorbed by your system. The body has to be detoxified in the liver, and the kidneys remove the metabolic end products in the urine. As many of the chemical ingredients in these cosmetics are cancer-producing substances, it is no wonder that the liver, the kidneys and the bladder are the target organs. Read more about the dirty dozen, the chemicals in cosmetics, in this link. Phthalates in the form of diethyl phthalate and dibutyl phthalate are commonly found in cosmetics and personal care products. They help nail polish to last longer and are industrial solvents.

In 2010 this Mexican study showed malformations in rodents after exposure of the mother to phthalates. Asthmatic children were also found in another study to have absorbed higher levels of phthalates than children that had no asthma. As a result phthalates have been illegal in many European countries, but not yet in Canada and the US. What should you do about this? For wrinkles use a product that consists of hyaluronic acid. (I found “Pure Hyaluronic Acid Facial Serum” from Complementary Prescriptions (Carson City, NV) and Yu InfiniSerum, a cream manufactured by Nutrazyne Research LLC, Highland, UT). Between both of those non-toxic skin applications you likely will not need any other cosmetics on your skin. If you feel you do, insist on natural ingredients that do not irritate your skin. Do you really need a lipstick? If you do, do not take one that contains lead or other cancer producing metals as was discussed recently on the news.

Mouth wash

Many people feel they have “bad breath” and they need a mouthwash. This is good marketing for companies that produce mouthwash. However, the truth is you need to have your gums looked at, brush your teeth regularly and floss your teeth. If you are constipated, increase your fiber intake and consider colonics. If you still think you have bad breath, use a natural mint product (read the ingredients). Why do I not like mouthwashes? They kill your mouth bacteria that are naturally there; this can disbalance the rest of your gut bacteria as you swallow part of the mouth flora when you eat or drink fluids. If you still want to use a mouthwash, use one without alcohol and without any carcinogens or parabens. Also read this 2009 news item. It is as valid as it was then.

Underarm deodorant

Here is an article that points out the danger of antiperspirants and breast cancer. The lesson to be learnt from this is that the propellants of sprays can be deadly when overused. So, use deodorants that are sticks to put or roll on. Next there is the aluminum content, which needs to be “0”. Aluminum is one of the substances responsible for Alzheimer’s disease when exposure to it occurs over longer periods of time. Parabens are often smuggled in as antifungals/antibacterials. They are hormone disruptors and xenoestrogens causing breast and prostate cancer. So, no propellants, not parabens, no aluminum! Triclosan is another substance that is added to the ingredients. As discussed before it is already is being recognized as hazardous! To choose the right deodorant it is important to read labels carefully, so you can make informed choices. Look for “aluminum free deodorant”. Next make sure that none of the bad chemicals described above are in the ingredient list. Read this info to educate yourself. Your best bet to find the right product is to go to the health food store or health food section of a store, as they usually carry a selection of natural, non-toxic products.

Conclusion

We owe it to our bodies to protect them from the chemicals that manufacturers produce with no concern about their customers’ health. You may ask yourself why cosmetics, toothpaste or other personal care products are even manufactured with cancer producing substances in them! It is up to the consumer to make the right choices and we do have many health-oriented choices available to us now. My hope is that through education we will influence the market to become more health-oriented.

Last edited June 1, 2013

Apr
14
2013

Allergies Not Only In Spring

Springtime is the time of spring allergies: those affected develop a runny nose, itchy eyes and in more severe cases they may experience a flare-up of asthma. Allergies can be triggered by the increase of pollen counts in the air that occurs every spring. In those who are sensitive, this leads to antibody formation in the blood. But often people have not only sensitivities to the pollens of spring bloomers; they may also be allergic to spores from molds, to dust mites and may have underlying allergies to foods. The immune system has memory cells that memorize that a person has had an allergic encounter to one of these items in the past, and allergic reactions can become more significant with a future encounter. Allergies can also be made worse when a person has food sensitivities and there are cross reactions between pollens of trees or grasses that can share surface protein regions with similar protein regions in foods.

It is known that cross allergies are possible between birch pollen and apple, carrots or hazelnut. In its extreme form allergies due to antibodies, called IgE antibodies, can cause anaphylaxis. A person presensitized by inhaling birch pollen, after eating an apple, hazelnuts or a carrot can develop itching of the throat, swelling of the lips and very quickly deteriorate getting into an anaphylactic shock.

Other cross allergies exist between ragweed pollen, which is a powerful inhalant allergen and melons or bananas. Again there are specific IgE antibodies that are responsible for this immune reaction. In this case the ragweed allergy primes the immune system to produce IgE antibodies, which are potentiated by certain foods that share similar protein components as the ragweed pollen.

In the following I will deal with inhalant allergies separately from food allergies.

Allergies Not Only In Spring

Allergies Not Only In Spring

Inhalant allergies

Inhalant allergies are easier to diagnose and to treat than food allergies. Your doctor will likely refer you to an allergist when you have allergies that do not respond to treatment with intermittent over the counter antihistamines. Your symptoms may come on in the spring with itchy eyes and a runny nose. From year to year you find that you become more and more dependent on antihistamines and nose drops to unplug your nose. The allergist likely will do sensitivity tests, which consist of skin prick or scratch tests on the back or the forearms.

In more serious allergies, where the patient has coughing and wheezing attacks following allergic reactions, the allergist may suggest to start intermittent allergy injections alongside the standard inhalation therapy for asthma. An allergy serum is prescribed where the lab mixes ingredients based on all of the positive tests that led to a strongly positive skin reactions when allergy testing was done. Typically the family doctor or his nurse will start the allergy injections initially in weekly intervals, later when the maintenance dose is reached, it may be modified to injections every 10 to 14 days.

The allergy injections stimulate the immune system to produce harmless competing antibodies, which counteract the disease producing allergic antibodies. In the process of desensitization shots the immune system will normalize, which means that the inflammatory response of the immune system settles down to normal.

This is not the end of the story with inhalant allergies. The patient needs to be retested on a yearly basis by the allergist. The immune system changes all the time as new allergies can develop and old ones may go away.

Retesting is necessary to keep track of what is going on and to change the composition of the allergy serum. Those patients who are working together with the allergist can do very well, and often they gradually outgrow their allergies. Others may not be so lucky. They may have reactions to the allergy injections. In these cases avoidance of what causes the allergy may be the only solution to treat the allergies.

There is an alternative to allergy injections, which has been used in Europe, namely a sublingual immunotherapy. Recently there has been a review of the literature for FDA approval that is needed for oral desensitization for ragweed, dust mites, grass pollen and cat dander. It will take some time before the FDA approval process will become a reality for sublingual desensitization in the US.

A special form of inhalant allergies are allergies to pets (mainly dogs and cats, but also allergies to petting zoo animals). The dander that the human comes in contact with is a protein contained in the animal hair. It causes hives when it touches the skin. This occurs as the dander is absorbed through the skin and meets the local mast cells that release histamine. This in turn is responsible for the hive formation. Sneezing and even asthma can develop from inhaled protein particles that reach the lungs. Allergy injections for the treatment of animal dander allergies are very limited as they often do not help or make the allergies worse. Avoidance of animal contact is usually what the allergist recommends as the solution, a recommendation, which often is not appreciated by the affected animal lover.

Food allergies

Often we eat  some foods more frequently, because they are our favorites. This means that our gut lymphocytes that get in contact with these foods can start to react to one or more of the foods we ingest. At this time we may experience abdominal cramps, diarrhea, vomiting and a host of other possible symptoms.

The physician will tell the patient that testing for food allergies is a problem as most of the usual skin tests employed for inhalant allergies do not reliably work in determining food allergies. The doctor will ask the patient or the mother of the child with food allergies to keep a food diary and keep track of the allergic symptoms in the diary as well. An elimination diet will have to be devised based on the information gathered in the diary as it becomes clear from that record which foods cause which symptoms. The foods causing allergic symptoms are subsequently eliminated. This is a cumbersome process, but it is the most reliable method of testing and treating food allergies.

In the past there was a blood tests, called RAST test, which tested for common food allergies that can cause severe allergic reactions like egg, milk, peanut, tree nuts, wheat, crustacean shellfish and soy. Since about 2010 this has been replaced by the more sensitive ImmunoCAP Specific IgE test.

Children often develop food allergies to egg, milk, wheat, nuts, peanuts and soy, which are food allergies with positive IgE tests. When they age, their immune system develops tolerance to many of these foods and they often outgrow these allergies.

There are other popular lab tests where a blood drop is analyzed with IgG, IgM and IgE antibodies against a panel of foods. A number of suppliers offer these tests.  However, the specificity, sensitivity and reliability can pose problems with regard to the interpretation of the results: allergists often point out that a test may be a false positive when a person likes certain foods and IgG antibodies against this food show up despite the patient having no symptoms. Another specialist may interpret this to indicate that the body shows early sensitization to a certain food, but clinically it is not yet obvious. In other words the sensitivity of the test is so high that it undermines the validity of the test. Recently a panel of international scientists reviewed the validity of these IgG based food intolerance tests and they found the tests not reliable.

The immune responses to food allergies are complicated as there are immediate type immune reactions and delayed type immune reactions. The immediate immune responses are investigated with the above mentioned ImmunoCAP Specific IgE test. The delayed immune responses can be measured using the ELISA test.

Other considerations about allergies

You see from this discussion that a patient with allergies needs a properly trained allergist who will do a comprehensive analysis involving a thorough history, examination, blood tests and immune tests.  The test results have to be interpreted with the experience and the clinical judgment of the specialist.

Since the 1970’s when Clearfield wheat was introduced around the world on a large scale, which has a much higher gliadin (gluten) content than the old wheat varieties. As a result of exposure to this new type of wheat gluten intolerance and leaky gut syndrome have increased substantially in the world population. Genetically modified foods like soy, corn, sugar beets, canola and more have challenged the immune system of sensitive humans even more to an extent, which is not fully understood yet. We do know that some people can develop autoimmune diseases and this may be the reason that a host of diseases that belong into this disease category (MS, rheumatoid arthritis, Hashimoto’s thyroiditis, ankylosing spondylitis etc.) are much more common now than in the past.

After food elimination for 2 to 12 months depending on the severity of the food allergy, your body may have eliminated the allergy to the food you have avoided, in other words your body built up tolerance. Before you expose yourself to any food that you used to be allergic to and that you want to re-test, it is best to have an EpiPen ready in case your allergy has not resolved. Caution is necessary with regard to foods that cause more severe allergies, e.g. shellfish or peanuts, which may last life long. It is safer to avoid these foods that cause more severe allergies altogether.

Allergic reactions of the immune system belong into the category of chronic inflammatory diseases. These are known to be the root of chronic diseases like asthma, arthritis, heart disease, high blood pressure and cancer. When you are vigilant about allergies and get proper assessment and treatment by an allergist, you will prevent serious health problems including the above mentioned chronic diseases.

More on asthma, which is a chronic inflammatory lung condition, often associated with multiple environmental allergies:

http://nethealthbook.com/lung-disease/asthma-introduction/

Last edited Nov. 6, 2014

Dec
01
2008

Treating Gastroesophageal Reflux Helps Asthmatic Kids

Asthma in children can be associated with allergies, but as Dr. Aaron K. Kobernick reported recently, other health conditions can also contribute to childhood asthma. He found that approximately two thirds of children with persistent asthma who had no allergic symptoms had another health condition, namely gastroesophageal reflux disease. The condition of acid reflux aggravates asthma. A prospective study examined children with moderate persistent asthma over a 2 year period. Initially the children underwent spirometry testing to assess their lung function. Another test involved monitoring of the acidity (ph values) in the esophagus of those children. The latter test demonstrated that the majority of the asthmatic kids also had GERD (gastroesophageal reflux disease).

Treating Gastroesophageal Reflux Helps Asthmatic Kids

Acid reflux aggravates asthma

 

 

 

Those children who were free of acid reflux received asthma medication only, but the patients with acid reflux and asthma received medication to treat the reflux.
In some cases surgical intervention was necessary. It became apparent that the children whose reflux was treated either surgically or with medication had an improvement of asthma symptoms of 22 to 25 %, whereas asthma medication alone contributed only to an improvement of 11%. Dr. Kobernick concluded that the large airways can react to the exposure of stomach acid, which results in an aggravation of asthma symptoms. Treating the acid reflux condition will result in less asthma in young patients with GERD.

More information on:

1. Asthma: http://nethealthbook.com/lung-disease/asthma-introduction/

2. GERD: http://nethealthbook.com/digestive-system-and-gastrointestinal-disorders/acid-reflux-gerd-esophagitis-barretts-esophagus/

Annual Meeting of the American College of Allergy, Asthma, and Immunology, November 6 – 11, 2008, Seattle, Washington

Last updated Nov. 6, 2014