Aug
22
2020

New Alzheimer’s Blood Test Is Promising

A new Alzheimer’s blood test is promising according to a publication in the Journal of the American Medical Association (JAMA) July 29, 2020. Alzheimer’s disease is a devastating neurological illness where people lose memory and judgment. If affects about 5.8 million Americans above the age of 65. Specialists are estimating that there will be 14 million Alzheimer’s cases by the year 2050.

For many years pathologists found amyloid plaque and tau tangles in Alzheimer’s patients’ brains, which accounted for their memory loss. Researchers developed a simple, inexpensive blood test, called phospho-tau217 (p-tau217). This is one of the tau proteins that is present in both plaques and tangles of living Alzheimer’s patients.

Plaques and tangles in the brain of Alzheimer’s disease patients

Many research papers describe that senile plaques are part of the cortex of brains of Alzheimer’s patients. They consist of beta-amyloid substance and of neurofibrillary tangles.

To put it simple: This protein material is like glue, which prevents the neurons from working properly. It also causes the memory loss and the confusion so typical for Alzheimer’s patients. Over the years the question then arose, where this glue substance ”beta-amyloid” came from. Dr. Yasojima et al. pointed out that for many years it was thought that this abnormal protein would have come from the liver and was then deposited in the brain. However, this research group presented evidence that the beta-amyloid actually comes directly from the cells in the brain where it is found and also deposited.

Beta-amyloid has antioxidant function

The amyloid-beta precursor protein is important for normal membrane function in the brain. It also has a very important antioxidant function in normal brains and keeps lipoproteins, an important chemical substrate of the brain, from getting oxidized. Recent research from the University of Pittsburgh School of Medicine linked these plaques with a loss of nitric oxide production in the brain, which would lead to a reduction of perfusion of brain blood vessels. This in turn can lead to a loss of oxygen and nutrients in the brain tissue.

Alzheimer’s patients have a regulation problem of amyloid-peptides

The Alzheimer’s patient’s brain appears to have a regulation problem where through some genetic or other mechanism, the auto-regulation of amyloid-peptides and other similar peptides appears to have been lost. There seems to be an overproduction of these peptides until they are no longer soluble. The insoluble surplus of these beta-amyloids is then deposited as the glue-like senile plaques that clog up the patient’s thinking, and reactive oxygen species are also released in these plaques damaging nerve tissue.

Back to why the new Alzheimer’s blood test is promising

Oskar Hansson, MD, PhD, Professor of Clinical Memory Research at Lund University, Sweden, stated the following. “While more work is needed to optimize the assay and test it in other people before it becomes available in the clinic, the blood test might become especially useful to improve the recognition, diagnosis, and care of people in the primary care setting.” The p-tau217 blood test mentioned at the beginning of this review correlates with the clinical condition of Alzheimer’s patients. Researchers evaluated the test in 1302 patients. Some had cognitive impairment others did not. The participants came from 3 large studies in Arizona, Sweden and Columbia. The Arizona branch provided 81 participants, Sweden provided 699 and Columbia 522.

Accuracy of the p-tau217 blood test

In the Arizona branch researchers could distinguish between with or without a “high likelihood of Alzheimer’s with an accuracy of 98%.

The Swedish BioFINDER Study discriminated between Alzheimer’s disease and other neurodegenerative diseases with an accuracy of 96%.

Finally, in the Columbia branch of the study researchers distinguished between mutation-carriers and non-carriers. They could predict who would develop Alzheimer’s  20 years before patients developed cognitive deficits.

All of the facts are not out yet about Alzheimer’s, but it is exciting to see the recent progress both in terms of early diagnosis and Alzheimer’s treatment. On the long-term prevention, as always in medicine, will prevail as the most effective method regarding diminishing the frequency of this disease.

10 steps that everybody can do today to minimize the risk of developing Alzheimer’s disease

  1. take 2000 IU of Vit. D3 per day
  2. get a T3 and T4 blood test to rule out hypothyroidism (doctors often do not order T3)
  3. Measure lead and mercury levels in urine and stool, particularly if you have more than 3 amalgamate tooth fillings
  4. If you test positive for mercury, go for intravenous chelation therapy, which specifically removes heavy metals (including mercury) from your system.
  5. People who do regular exercises and follow good nutrition get less Alzheimer’s disease. As Alzheimer’s patients are deficient in magnesium intake, it is wise to take a magnesium supplement as discussed in Ref. 22.

Further steps to prevent Alzheimer’s disease

  1. Omega-3-fatty acids (molecularly distilled Omega-3 or cod liver oil capsules etc.) and/or fish help you to preserve brain cells.
  2. Take the nutrient phosphatylserine (PS) 100 mg once daily for prevention of Alzheimer’s and dementia.
  3. Cutting out sugar and starchy food by following a low-glycemic diet brings elevated insulin levels back to normal.
  4. Mayo Clinic research recently showed that computer-based memory exercises in seniors will lead to significantly less Alzheimer’s disease in the years down the road.
  5. Progesterone cream (only bio-identical, from compounding pharmacy) has anti-Alzheimer effects. Women would incorporate this into their bio-identical hormone replacement schedule following menopause. Men would utilize the brain rejuvenating effect of testosterone into their hormone replacement routine following andropause.

Both also take small amounts of oral DHEA and pregnenolone, but have blood or saliva tests from time to time to measure hormone levels.

New Alzheimer’s Blood Test Is Promising

New Alzheimer’s Blood Test Is Promising

Conclusion

Alzheimer’s disease is a severe, disabling neurodegenerative disease of the brain. At this point there has not been an early diagnostic test. But a recent publication in the Journal of the American Medical Association (JAMA) describes a simple blood test, called phospho-tau217 (p-tau217). This is one of the tau proteins that is present in both plaques and tangles of living Alzheimer’s patients. A clinical trial showed that when this test is positive, it predicts up to 20 years from now that this patient likely will come down with Alzheimer’s disease. Based on this publication there will soon be a simple blood test that diagnoses Alzheimer’s disease early and reliably with an accuracy of between 96% to 98%. Lifestyle interventions may then be able to prevent the deterioration of cognitive functions. Further therapeutic interventions may come about through more research.

Part of the text was published before under the link indicated.

Aug
01
2020

Eating Fish Protects the Brain from Air Pollution

Research on white women aged 70 years or older found that eating fish protects the brain from air pollution. Dr. Ka He from the Columbia University of New York published the new study on July 15, 2020 in the online issue of Neurology®, the medical journal of the American Academy of Neurology.

1,315 women who did not have dementia at the start of the study enrolled in it. Researchers measured the air pollution of the areas where the women lived. They also measured their omega-3 fatty acid blood levels. They found that women from polluted areas who ate the lowest amounts of fish and had the lowest amounts of omega-3 fatty acids in their blood, had the highest amount of brain shrinkage.

Methods of determining brain shrinkage, omega-3 fatty acids and pollution

The amount of brain shrinkage was determined with MRI scans of the brain. The amount of white brain matter was measured, particularly the size of the memory-sensitive hippocampus. Blood omega-3 fatty acid content was determined in red blood cells. Pollution was determined by the fine particulate matter in air pollution at the address where the patient lived. Every woman in the study received a diet questionnaire regarding fish consumption. From this information the researchers determined the average fish consumption per week. This included broiled and baked fish, non-fried shellfish, canned tuna, tuna casserole and tuna salad. Deep fried fish was not part of the list, because other studies showed that deep-frying damages omega-3 fatty acids.

More details regarding the study

The researchers adjusted the study according to age, smoking status, and other factors that could affect brain shrinkage. Women with the highest intake of omega-3 fatty acids had the highest volume of white matter in their brains as MRI scans showed. Specifically, the researchers noted the following findings:

  • Women with the highest omega-3 fatty acid level had 410 cubic cm white matter
  • Women with the lowest omega-3 fatty acid level had 403 cubic cm white matter
  • Each quartile increase in air pollution caused shrinkage of white matter by 11.52 cubic cm in those women with low omega-3 fatty acid consumption
  • In women with higher omega-3 fatty acid levels each quartile increase in air pollution caused shrinkage of white matter by only 0.12 cubic cm
  • Women with the highest omega-3 fatty acid intake had the highest volume of the hippocampus

Comments by the lead author of the study

Dr. Ka He stated: “Our findings suggest that higher levels of omega-3 fatty acids in the blood from fish consumption may preserve brain volume as women age and possibly protect against the potential toxic effects of air pollution.” But Dr. Ka He cautioned: “It’s important to note that our study only found an association between brain volume and eating fish. It does not prove that eating fish preserves brain volume. And since separate studies have found some species of fish may contain environmental toxins, it’s important to talk to a doctor about what types of fish to eat before adding more fish to your diet.”

Limitations of study

The study was involving older white women. This means that the results cannot be generalized to Afro Americans, Hispanics or Asians. The researchers examined exposure to pollution only later in life, not in early life or midlife. Hopefully future studies will examine what happens with lifelong exposure to pollution.

How to limit mercury exposure when eating fish

Omega-3 fatty acids are abundantly present in fish. It has plaque-reducing properties and also reduces the risk for abnormal heart beats. Overall this means less cardiovascular disease. The American Heart Association recommends a 3.5 oz. serving of fatty fish (salmon, mackerel, lake trout, herring or sardines) twice per week.

Mercury and other pollutants

Pollution of the air, soil and rivers is causing accumulation of mercury and other heavy metals in ocean water.

This affects fish that live in the ocean. There is a pecking order of predators with the larger fish feeding on the smaller fish. The bigger the predator fish, the more mercury and other pollutants they accumulate. According to this link the safest seafood is wild salmon, pollock and oysters.

High mercury content of predator fish

Tuna is too high in mercury, so is swordfish, and shark is even worse. I only consume fish from freshwater lakes or rivers, as well as salmon, oysters and shrimp. This way I get the lowest exposure to mercury. Why is mercury bad for you? It is a neurotoxin. It can harm your brain, heart, kidneys, lungs and the immune system. Specific symptoms can include loss of peripheral vision and lack of coordination with balancing problems. There may be impairment of speech and hearing. The key is to avoid mercury exposure.

Smaller fish low in mercury

The first line of defense is to stick to the smaller fish. They are they prey of the large predator fish. The following fish/mussels belong into the low mercury group (alphabetical order): anchovies, catfish, clam, crab, crawfish, flounder, haddock, herring, mackerel, mullet, oyster, perch, pollock, salmon, sardines, scallops, shrimp, sole, squid, trout and whitefish.

Molecularly distilled omega-3 fatty acid supplements

You may want to supplement your omega-3 fatty acid intake by fish oil capsules. It is important that you choose the more expensive higher potency products. A molecular distillation process that removes mercury, PCB and other heavy metals creates these higher potency products. This way you only get the enriched omega-3 fatty acids in pure form. EPA and DHA in one capsule should be in the 900 mg to 1000 mg range, not less. I take 2 capsules twice per day as a daily supplement. This helps you to balance the omega-6 to omega-3 ratio, which cuts down any inflammatory process (from too many omega-6 fatty acids) in you.

Eating Fish Protects the Brain from Air Pollution

Eating Fish Protects the Brain from Air Pollution

Conclusion

A new study from the Columbia University of New York has shown that women older than 70 can preserve the white matter of their brains by consumption of fish. This included the hippocampus which is crucial for memory. The researchers measured the recent exposure of these women to pollution. They noted that the women who were exposed to the highest amounts of pollution had the best protection of the white matter of their brains by the highest consumption of omega-3 fatty acids from fish. Omega-3 fatty acids are also important to prevent heart attacks and strokes. Omega-6 fatty acids can cause inflammation, but when enough omega-3 fatty acids are part of the nutrition, the omega-6/omega-3 fatty acid ratio switches towards anti-inflammation and health.

How to consume omega-3 fatty acids safely

Omega-3 fatty acids are in fish and seafood. Unfortunately, mercury is contaminating these foods. But when you stick to the smaller fish and use molecularly distilled omega-3 supplements you can largely avoid this problem.

Parts of this text has been published before here.

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Feb
29
2020

Celiac Disease in Various Disguises

Dr. Tom O’Bryan gave a lecture in Las Vegas on Dec. 13, 2019 about celiac disease in various disguises. This was at the 27th Annual World Congress on Anti-Aging Medicine. The title of his talk: “An Ounce of Prevention Is Worth a Pound of Protocols: Halting Our Brains Slow Deterioration”.

Case # 1: 44-year old male with an assumed diagnosis of ALS

In the first place a 44-year old male had a history of a right leg weakness that developed over the last 6 months. He had intermittent spasms in his right quadriceps muscle. In addition, over the last few months he noticed a weakness develop in his right arm with difficulties writing. Significantly, his family history revealed that a maternal aunt had celiac disease. Moreover, a sister had Crohn’s disease and his maternal grandmother had multiple sclerosis. Electromyographic studies showed widespread acute denervation. An MRI scan of the spine showed hyperintensity in the corticospinal tracts. A diagnosis of amyotrophic lateral sclerosis (ALS) followed as a result based on the MRI scan findings.

Further tests

At the same time blood tests revealed that his anti-endomysial antibodies were elevated.  Duodenal biopsy demonstrated villous atrophy, crypt-hyperplasia and increased intraepithelial lymphocytes consistent with gluten-sensitive enteropathy (celiac disease). An MRI scan of the brain also showed some hyperintense lesion in the left-brain hemisphere.

Gluten free diet instituted

It was clear with these test results that the initial diagnosis was a misdiagnosis. The real diagnosis was celiac disease. 7 months after the onset of his symptoms he started on a gluten free diet. He received no medications. Notably, his right arm function returned to normal after 9 month of the gluten free diet. Although there was some improvement in his right leg function, he still had some muscle wasting and spasticity in his right leg. However, he could now walk without any aid. His hand-writing was back to normal, and he could button his shirts again. Repeat MRI scans followed 2 months and 9 months after the start of the gluten free diet. At two months after initiation of the gluten free diet the brain lesion in the left brain was somewhat larger than before, but at 9 months it was half the original size.

Case #2: Autism in children, youth depression and Alzheimer’s patients

The autism spectrum disorder (ASD) has significantly increased from 1 in 166 in 2004 to 1 in 40 in 2018. In addition, Dr. O’Bryan also mentioned that in 2017 statistics showed that 13.3% among youth aged 12 to 17 in the US suffered major depressive episodes. 1 in every 12 youth suffer from severe behavioral and emotional problems. According to the CDC since 1994 the number of children on psycho-stimulants increased 5-fold. In the same time children under 18 with bipolar disorder have increased 40-fold. There has been a 6-fold increase of prescriptions for antipsychotic medications for children in the same time frame.

Other effects on adolescents

However, I like to point out that there are other powerful factors that can explain increased depression and emotional problems in adolescence. The Canadian Medical Association published an article about social media and smart phones and the effects they have on adolescence.

On the other end of the life cycle 1 in 3 seniors die with Alzheimer’s disease or dementia. Between 2000 and 2015 death from Alzheimer’s disease has increased by 213%.

Breakdown of the blood brain barrier

According to Dr. O’Bryan autism in children, behavioral and emotional problems in teenagers and dementia from Alzheimer’s disease are all related to the same process, namely a breakdown of the gut barrier, often called leaky gut syndrome. It is important to realize that this leads to a secondary breakdown of the blood brain barrier. The end result is a compromise of the brain, where antibodies attack the brain protein. In young children this causes lower adaptive and cognitive function and behaviors typical for autism. Teenagers are more likely to present with depression or schizophrenia. In older people the breakdown of the blood brain barrier can result in Alzheimer’s disease and other forms of dementia.

25 to 30% of protein in wheat are non-gluten. Antibodies can be directed against gluten, but also against non-gluten protein.

IgG antibodies against gluten cross placenta

In the later stages of pregnancy IgG antibodies cross the placenta easily. They provide passive immunity from various viral infections. Unfortunately, antibodies against gluten also cross through the placenta, which can lead to a breakdown of the fetal gut lining, in the sense of leaky gut syndrome. In this study 211 children were found to have a risk of 1.7-fold to develop psychosis later in life. The mothers were positive for anti-gliadin IgG antibodies in the last 4 weeks of pregnancy. Anti-casein antibodies did not have this psychosis effect (risk only 0.8-fold). The investigators felt that an allergy to wheat in the mother set up general inflammation. Psychosis in the offspring only develops when inflammatory mediators reached the brain of the fetus. It was the brain inflammation, which caused the subsequent psychosis later in the child.

Blood brain barrier and healthy gut barrier

Another key point is that the barrier both in the gut and in the blood brain barrier consists of a single epithelial layer. The cells are held together by zonulin and occludin proteins. Autistic children were exposed already in the uterus to mother’s wheat induced anti-gliadin antibodies. This led to a break-down of the children’s blood brain barrier and the symptoms of the autism spectrum disorder. These children have a lot of brain inflammation and in addition often have impaired gut barrier integrity. It must be remembered that they require a comprehensive program to improve the gut flora, build up the gut barrier integrity and re-establish the blood brain barrier.

Effects of phthalates on young children

A 2014 study measured urinary metabolites of phthalates and related this to the children when they were 7 years old.

The investigators did several cognitive tests and measured the IQ (Wechsler Intelligence Scale). Children of mothers with the highest quartile of phthalates had an IQ, which was on average 7.0 points lower than the control group of the lowest quartile of phthalates. Dr. O’Bryan showed a slide taken from this study.

With this in mind, it points out that a pregnant woman has an intact blood brain barrier, which prevents antibodies from entering. However, the immature brain of the fetus has not developed an efficient blood brain barrier yet. This allows maternal gliadin antibodies from wheat intolerance to enter the fetal brain and cause autism spectrum disorder (ASD).

PCB’s disrupt the blood brain barrier

In mouse experiments the effects of PCB’s were investigated. By the same token, researchers found that the blood brain barrier was broken down by PCB’s that are known to have carcinogenic and neurotoxic properties on the brain. The researchers injected melanoma cells into the animals and found that the PCB pretreated mice sustained brain metastases. However, the control animals that did not have PCB pre-treatment did not develop brain metastases. They concluded from this that PCB’s are breaking down the blood brain barrier.

Maternal brain antibodies causing autism in children

This publication examined antibodies to two different brain proteins. The researchers found that 86% of the children from mothers with two different fetal brain antibodies were diagnosed with autistic regression. According to this publication there are at least 50 different epitopes of gluten peptides that exert cytotoxic, gut permeating and immunomodulatory activities.

DNA microarray technology can now detect many subtypes of food disorders and gluten sensitivities. The tests for celiac disease have a sensitivity of 97% for IgG and 99% for IgA. With regard to specificity the test is now 98% accurate for IgG and 100% for IgA.

Case #3: 34-year old female vegan patient with depression and mild cognitive decline

A 34-year old woman has followed a Vegan lifestyle for 10 years. She has been working long hours and had a lot of stress. In addition, her thyroid was borderline low with high TPO antibodies. A blood test for vitamin D showed vitamin D deficiency. For the past year her energy level was low and she had developed chronic depression. Her physician did a genetic test that found she carried the gene that converts GABA into glutamate. She thinks that she has small intestinal bacterial overgrowth (SIBO). A review of her dietary habits revealed that she ate more cooked foods and less raw food. Her memory is slightly off, her speech not as fluid and she has some cognitive decline.

Her blood tests showed anti-immunity to RAGE peptides. To put it another way, RAGE stands for “receptor for advanced glycation end products”. When you eat too much overcooked foods you ingest advanced glycation end products. This can have adverse effects on your body, particularly the brain.

More tests regarding this woman

Another specific test revealed a blood brain barrier disruption with the presence of anti-brain antibodies. A stool sample was obtained. It showed low Akkermansia, low Faecali bacterium, low Bifido longum and low Bifido adolescentis bacteria. A chemical analysis revealed low butyrate, propionate and acetate. The treating physician concluded that she had a gut dysbiosis and a dysfunctional gut barrier. This has also affected her blood brain barrier. The constellation of symptoms and blood tests explain her clinical condition. She has developed autoantibodies that affect her thyroid gland and her brain because of the antibodies against her RAGE peptides. People can develop Alzheimer’s disease given enough time with exposure to these antibodies. The leaky gut has led to a break-down of her blood brain barrier and exposed her brain to autoimmune antibodies directed against brain cells.

Treatment of gut dysbiosis

This patient started a gluten free diet (GFD). But one of the problems of the GFD is that wheat is removed that normally provides 69% inulin and 71% oligofructose, both important prebiotics that are necessary for probiotics to work with. Inulin is contained in beets, leeks, asparagus, onions, garlic and bananas. Oligofructose is contained in chicory root, bananas, onion, and garlic.

When people consume a typical Western diet, they get between 1 and 4 grams of inulin daily. But others who eat balanced diets get up to 25 to 100 grams of inulin per day. Dr. O’Bryan explained that going on a GFD leads to an altered microbiome.

Experiment with volunteers to measure the effects of a gluten free diet

He discussed an experiment on 10 healthy volunteers who were fed a GFD for 1 month.

The researchers ordere stool samples in the beginning and at the end of the experiment. There was less of the good bacteria and more of the the bad bacteria. This led to a less protective and more inflammatory environment. The remedy for that is to eat 1 root vegetable and 2 other prebiotics per day. The patient on a GFD must supplement with prebiotic-rich foods to prevent this from happening.

Non-digestible oligosaccharide supplement

Inulin and oligosaccharides support the intestinal microbiota.  Dr. O’Brien suggested to add a supplement, called Precision Prebiotic™, non-digestible oligosaccharides that can increase microbial diversity. This supplement supports the growth of the healthy bacteria. These are keystone bacteria like Akkermansia muciniphila, Faecal bacterium prausnitzii, and Bifidobacteria.

Other supportive measures for the gut

  • 1 tablespoon of fermented vegetables like sauerkraut once per day
  • The ingestion of fermented foods increases the beneficial gut bacteria by a factor of 10,000-fold!
  • A 100% spore-based probiotic supplement increases diversity of the gut flora and helps to maintain the gut barrier
  • Sodium butyrate, which comes from fermented food is an important modulator of the central nervous system
  • In addition, sodium butyrate also inhibits pathological gut bacteria and maintains the gastrointestinal balance
  • In neurodegenerative disorders sodium butyrate provides anti-inflammatory and neuroprotective effects
  • Sodium butyrate restores the blood brain barrier
  • Following heart attacks or strokes sodium butyrate promotes tissue repair and recovery through cell survival
Celiac Disease in Various Disguises

Celiac Disease in Various Disguises

Conclusion

Dr. Tom O’Bryan delivered a lecture at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas on Dec.13, 2019. Wheat allergies have increased in the last decades. Researchers have found that in many people there is a deterioration of the gut flora and a breakdown of the gut barrier. This leads to antibody formation against gluten or gliadin (wheat proteins). This exposes the body to many proteins from the gut. The body reacts by producing antibodies to them. These are also affecting cells in the body as they cross react with body proteins. The inflammation from the autoantibodies cause the blood brain barrier to break down. Now the immune system can produce antibodies against brain tissue. In the past  with an intact blood brain barrier this was not possible.

Autoantibodies in various life epochs

At a young age autism can develop because of antibodies against gliadin from wheat. In our youth schizophrenia and depression can occur from gut dysbiosis and a subsequent break down of our blood brain barrier. In old age Alzheimer’s disease develops in 1 out of 3 people due to gut dysbiosis and a breakdown of the blood brain barrier with anti-brain antibodies. Dr. O’Bryan explained how a person can turn this negative spiral around and start a new life without these problems. You can avoid a lot of these diseases by eliminating wheat and processed food from your diet.

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Nov
16
2019

Trans Fat Causes Alzheimer’s Disease

The FDA is aware for some time that trans fat causes Alzheimer’s disease. This is why the FDA has outlawed trans fats in 2015. But the industry was given 3 years to phase out trans fats. The FDA also gave special extensions to many companies, which allows these companies to continue adding trans fats into your food until January 2020. CNN reported about a Japanese study that examined the correlation between trans fat levels in the blood and the risk of coming down with Alzheimer’s disease.

Japanese trans fat study

This Japanese study followed 1,628 Japanese community residents (men and women) for about 10 years. Researchers used the typical trans fatty acid, elaidic acid to monitor the accumulation of trans fats in patients. This is possible with a simple blood test, which serves as a marker for industrial trans fats. 377 participants developed dementia (247 Alzheimer’s disease and 102 vascular dementia). Based on the blood elaidic acid levels earlier in the study individuals with higher trans fat levels were more likely to develop Alzheimer’s disease as the study progressed. Patients whose trans fat blood levels were in the higher range were 50% to 75% more likely to develop Alzheimer’s disease or dementia.

Comment by an Alzheimer’s researcher

Dr. Richard Isaacson, director of the Alzheimer’s Prevention Clinic at Weill Cornell Medicine in New York was not involved in the study. But he commented on the importance of it. He said: “The study used blood marker levels of trans fats, rather than more traditionally used dietary questionnaires, which increases the scientific validity of the results.” He continued: “This study is important as it builds upon prior evidence that dietary intake of trans fats can increase risk of Alzheimer’s dementia.”

Other studies that indicate that trans fats cause Alzheimer’s disease

On June 10, 2019 researchers published a paper that stated that three simple steps would prevent strokes and heart attacks. Heart disease is the leading cause of death for both men and women. In the US about 610,000 people die of heart disease every year, which is about one in every 4 deaths. Here are a few facts. First, there is the simple observation that patients do not control their high blood pressure enough to avoid a heart attack or stroke. Secondly, patients with high blood pressure need to restrict their salt intake, or they will develop heart attacks or strokes. Finally, patients need to avoid exposure to artificial trans fatty acids as this leads to direct damage of the lining of the arteries.

Why avoiding artificial hydrogenated fats is important

Given enough time, this will cause heart attacks and strokes. If patients survive to a ripe old age, they will develop Alzheimer’s disease as well. Apart from controlling blood pressure and restricting salt intake the third factor was to avoid artificial hydrogenated fats.

Hydrogenated fatty acids or trans fats

Hydrogenated fatty acids or trans fats still make their way into the grocery-shopping basket. They are present in baked goods, snacks like chips, creamer and margarines. Think of cakes and cookies, crackers, piecrust, potato chips, corn chips and microwave pop corn. Deep fried food is also full of trans fats (french fries, doughnuts, fried chicken). Trans fats can make their way into frozen pizza crusts, non-dairy coffee cream, canned biscuits and cinnamon rolls. Above all do not buy any form of margarine. Hydrogenated fatty acids affect the arteries directly by increasing the harmful LDL cholesterol and decreasing the protective HDL cholesterol. This accelerates hardening of the arteries, which in turn causes heart attacks, strokes and on the long run Alzheimer’s disease. 

Eliminate trans fats

We need to eliminate trans fats as they are causing heart attacks and Alzheimer’s disease. There is an important difference between ruminant trans fats and artificial trans fats. Ruminant trans fats have been part of the human diet for millennia like milk fat and fat from cows, goats or sheep that are on pasture. Milk products for instance contain fat with 2-5% natural trans fats. 3-9 % of the fat in beef and lamb consists of natural trans fats. Studies have shown that the body is able to handle these natural trans fats, and heart attacks are not more frequent in people eating moderate amounts of these products including butter from cows that graze on pasture.

Artificial trans fats

Quite the opposite is true for artificial trans fats in margarine that comes from vegetable oil. Avoid bakery items like sweet pieces or muffins and other products that contain hydrogenated oils. Read labels! Use olive oil or coconut oil, but avoid vegetable oils like corn oil, safflower oil or grape seed oil to get away from trans fats and unstable oils that turn rancid. Rancid oils contain free radicals that oxidize LDL cholesterol and attack the lining of your arteries through small dense LDL cholesterol. Remember that merchants add artificial trans fats to prolong the shelf life of processed food. Your best defense against trans fats is to not buy processed foods. This is what I do.

Poor diet habits can cause Alzheimer’s

A new study from the Brock University in St. Catharine’s, Ont. showed that poor diet habits can cause Alzheimer’s. A significant risk for Alzheimer’s was a combination of high saturated fats in the diet in combination with too much sugar. Another triggering factor was the normal aging process that also contributed to the development of Alzheimer’s.

Study showing that poor diet habits can cause Alzheimer’s

Master student Bradley Baranowski and PhD student Kirsten Bott conducted the experiments under the supervision of Assistant Professor of Health Sciences Rebecca MacPherson. The experimental group consisted of middle-aged mice that were observed for 13 weeks. They received a high-fat/high-sugar diet. The control group received a normal diet.

The experimental group with the high fat/high sugar diet was aging prematurely. They also showed elevated inflammatory markers, elevated insulin levels and cellular stress. Dr. MacPherson mentioned that the middle-aged mice would be comparable to humans aged 40 to 60. “We’re trying to see what the initiating signals are that can lead to progression of Alzheimer’s disease,” MacPherson said.

Lifestyle choices matter

“People often view Alzheimer’s disease as a genetic disease when in fact, genetic mutations leading to Alzheimer’s accounts for less than five per cent of cases,” Baranowski said in the press release. “This study highlights that our lifestyle choices matter and can potentially put us at risk of developing or progressing neurodegenerative diseases such as Alzheimer’s.”

Over the years many other researchers have analyzed what factors contribute to developing Alzheimer’s. It probably is a combination of several factors.

Trans Fat Causes Alzheimer’s Disease

Trans Fat Causes Alzheimer’s Disease

Conclusion

Researchers are aware of trans fats causing Alzheimer’s disease, heart attacks and strokes for a long time. They increase the bad LDL cholesterol, decrease the good HDL cholesterol. Rancid oils contain free radicals that oxidize LDL cholesterol and attack the lining of your arteries through small dense LDL cholesterol. The FDA has started to initiate steps in 2015 to make the use of trans fats in the food industry illegal. Completion of this in the US occurs in early 2020. Many countries are more lax in their laws. It is up to the consumer to read food labels and decide not to buy certain products known to contain trans fats like frozen pizza crusts, non-dairy coffee cream, canned biscuits and cinnamon rolls, just to mention a few. Eliminate artificial trans fats from your food and avoid the risk of Alzheimer’s disease.

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Jul
20
2019

Common Drugs Have A Connection To Dementia Risk

A recent publication stated that common drugs have a connection to dementia risk. The study had an observation time of 12 years (from 2004 to 2016) and involved 284,343 patients in the United Kingdom. There is a group of drugs, namely anticholinergic drugs, that were particularly strong with regard to causing side effects of dementia. A variety of anticholinergic drugs exist, such as antidepressants like paroxetine or amitriptyline. But there are other anticholinergic drugs like bladder antispasmodics (they also go by the name bladder antimuscarinics, such as oxybutynin or tolterodine). Other anticholinergic medications are antipsychotics that are in use for psychotic diseases. Examples are chlorpromazine or olanzapine. Anti-epileptic drugs also belong into the anticholinergic drug group. Common anti-epileptic drugs are oxcarbazepine or carbamazepine.

The researchers found that 58,769 of the patients that took strong long-term anticholinergic medication developed a dementia diagnosis.

More about the study

The researchers found that the risk of developing dementia for those who consumed only a few anticholinergic drugs was low. It amounted to only 6%. In contrast, patients who took a lot of anticholinergic drugs at least for 3 years or more developed dementia in 49% of all cases, which is quite a significant amount.

Dr. Douglas Scharre, director of the division of cognitive neurology at the Ohio State University Wexner Medical Center in Columbus was not involved in the study. He said: ”I spend a lot of my time in the memory disorder clinic seeing geriatric patients and taking people off medications, mostly those medications that have anticholinergic properties. Many times there can be another drug out there that has less anticholinergic impact or is non-anticholinergic that may work.”

Risk-benefit discussion

He went on to say that some drugs are really necessary to control a psychosis or seizures, so it is a matter of discussing with the physician whether it is worth taking a risk of possible dementia versus a risk of a flare-up of psychosis or of a seizure.

More statistics

Patients who received treatment for depression with anticholinergic antidepressants had a risk of 29% of developing dementia. Anticholinergic anti-Parkinson drugs had an association of a rate of 52% of dementia. Anti-psychotic drugs led to dementia in 70% of the treated cases. Bladder relaxing medications (medically called antimuscarinic drugs) had a risk of 65% to cause dementia. Finally, anti-epileptic drugs had a risk of causing dementia in 39%.

The researchers noted that these findings highlight how important it is reducing exposure to anticholinergic drugs in middle-aged and older people.

Serious side effects from other medication

Unfortunately there is a history of serious side effects regarding several medications.

Tardive dyskinesia with antipsychotics

Long-term treatment of schizophrenia with antipsychotic drugs can cause severe side effects. One of the more severe side effects is tardive dyskinesia, which occurs in 5% per year of antipsychotic medication use, and in about 1%-2% of these it is severely disfiguring the face. Tardive dyskinesia can lead to permanent involuntary movements of the muscles around the mouth and the eyes. The jaw and the tongue may also show involuntary movements, and in time this leads to a disfigured look of the face, often with asymmetries between the right and left side of the face. Unfortunately, withdrawal of the antipsychotic medications will not improve the tardive dyskinesia. Often expensive lifelong Botox injection therapy every 6 to 8 weeks is necessary to alleviate some of the effects of this devastating dyskinesia.

Side effects from antacid pills

Lansoprazole (Prevacid) belongs to the proton pump inhibitors and is a very strong acid production inhibitor. Because it is so reliable in suppressing stomach acid, it is popular with the public. What is not so well known are the side effects of this drug. The most common side effects are about bone fractures, severe diarrhea, kidney damage, systemic lupus erythematosus and fundic gland polyps. These polyps can later turn into stomach cancer. Unfortunately, drug companies do not always report about the less frequent side effects.

A rare side effect: muscle tremor

One of these side effects is a muscle tremor (jerking movements or shaking). It is listed under the side effects way down the list where you may overlook this. To the patient it can be devastating as the symptoms are very similar to Parkinson’s disease. Imagine a 40-year old man taking this medicine for stomach acid and coming down with these muscle tremor symptoms! Fortunately, when you recognize the connection, you can stop the medication and the symptoms frequently go away or at least diminish.

Rhabdomyolysis from statins

When a patient is receiving statins because of high cholesterol, one of the possible side effects can be rhabdomyolysis. This typically presents with muscle weakness, fatigue, and lower urine output. The urine may be of a dark color. Confusion, vomiting and agitation can also set in. It is necessary to immediately recognize these type of side effects, and the statin drugs should be stopped. The patient requires a kidney specialist to watch the kidney function. Often these patients need treatment in hospital. 

Cancer and heart attacks from synthetic hormones

The “Women’s Health Initiative” with a study on 16,000 postmenopausal women had to be stopped prematurely in 2002. This was a study that examined the effects of two synthetic hormones, the estrogen Premarin and the progesterone-like substance Provera. The purpose of the study was to show whether heart attacks, osteoporosis and strokes would be reduced on hormone replacement compared to controls. But the results were shocking: the opposite was true! The risk in the treatment group for strokes was 41% higher than for the controls and for heart attacks it was 29% higher! But this was not all. The treatment group had twice as many blood clots in their legs and 26% more breast cancer. Colorectal cancer was 37% higher and Alzheimer was a whopping 76% higher than in the controls.

Synthetic hormones caused estrogen dominance

The synthetic hormones functioned like xenoestrogens, meaning that there was a partial resemblance of the synthetic hormones to estrogen and progesterone, blocking their hormone receptors, but not stimulating them. The end result was an estrogen dominance state in the blood, which caused all of the problems. When bioidentical hormone replacement is done with bioidentical estrogen and progesterone, the opposite is the case. Women live longer because they get less heart attacks and strokes; they also get less cancer. In Europe bioidentical hormone replacement has been in use for over 50 years, and in the US physicians who use bioidentical hormone replacement have experience for almost 30 years.

Discussion

We started this article describing side effects of anticholinergic drugs and how this can bring on dementia. Other researchers have noted that dementia and strokes can be brought on by diet drinks. We then got into side effects of other drugs like tardive dyskinesia with antipsychotic drugs. We discussed the possibility of tremors from antacid drugs. A rare side effect of statins is rhabdomyolysis. And we talked about cancer and heart attacks from synthetic hormones in postmenopausal women. We need to be aware that any chemical brought into our system can cause undesirable side effects. Chemicals like drugs can interfere with biochemical reactions in the body that ultimately result in side effects including cancer and heart attacks.

Common Drugs Have A Connection To Dementia Risk

Common Drugs Have A Connection To Dementia Risk

Conclusion

In a recent publication we learnt that patients who took a lot of anticholinergic drugs at least for 3 years or more developed dementia in 49% of all cases, which is quite a significant amount. But there are other drugs that have serious side effects. For instance, there is tardive dyskinesia, a disfiguring condition in the face that can develop with antipsychotic medicine for schizophrenia. Statins can cause a painful muscle condition, rhabdomyolysis. The “Women’s Health Initiative” showed a study that examined the effects of two synthetic hormones, the estrogen Premarin and the progesterone-like substance Provera.

Synthetic hormones causing problems

The purpose of the study was to show whether heart attacks, osteoporosis and strokes would be less on hormone replacement compared to controls. Unfortunately quite the opposite happened. The risk in the treatment group for strokes was 41% higher than for the controls and for heart attacks it was 29% higher! But this was not all. The treatment group had twice as many blood clots in their legs and 26% more breast cancer. Colorectal cancer was 37% higher and Alzheimer was a whopping 76% higher than in the controls. Only bioidentical hormones are tolerated without any side effects. We need to treat our bodies with respect and stay away from noxious substances.

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Sep
29
2018

No Amount Of Alcohol Is Good

New research, more extensive than previous research has shown that no amount of alcohol is good.

This is completely against the widespread belief that moderate consumption of alcohol would prevent heart disease.

Specifically, previous research had shown the following: one glass of alcohol per day for women and 2 glasses of alcohol for men was reportedly make us live longer.

New research with larger population numbers

But a new study involving much larger population groups, all ages, and drinkers versus non-drinkers came to a different conclusion. It concluded that the previous recommendation was based on only heart attack rates, but excluded other causes of sudden death like heart failure, a rupture of the aorta (aneurysm), high blood pressure that kills (fatal hypertensive disease) and strokes. With the compilation of all these cardiovascular diseases, the statistics suddenly started to look different. Now even small amounts of alcohol killed. What is worse, there was clear evidence that binge drinkers have much worse survival statistics than moderate drinkers. When you drink according to the American Heart Association’s recommendation, you drink smaller amounts of alcohol daily.

Binge drinking

But many of us like to live it up on weekends or whenever there are friends over who also like a few drinks. This binge drinking habit lowers the life expectancy by an average of 10 years. It does so because the list of complications I mentioned above. In addition there are alcoholic liver cirrhosis, pancreatitis and various cancers that shorten your life.

Global health study

The funders of this global health study was the Bill and Melinda Gates Foundation, and it looked at the burden that alcohol puts on 195 countries. The original study appeared in the Lancet. The combined study population was 28 million individuals. There were 649,000 cases of various deaths due to alcohol. Here is a summary of the abbreviated outcome of the global health study. As you can see from this, there is no safe level of alcohol consumption as even small amounts of alcohol over a long period of time lead to significant damage in the body. You can prevent heart attacks to a certain extent. But instead people die from a ruptured aorta, from strokes or from heart failure. The leading cause of death for men and women age 15 to 49 worldwide was alcohol. It accounted for almost 1 in 10 deaths.

Some alcohol-related statistics

The following were the observaions in the study.

  • Over 300 disabilities and diseases were directly related to alcohol consumption. The findings were collected in 195 countries, classified by age and sex. The data was gathered between 1990 and 2016.
  • Globally, 2.4 billion people drink alcohol. 25% are women who consume 0.73 drinks on average each day, 39% are men drinking 1.7 drinks a day.
  • Denmark, Norway and Germany drank the most alcohol globally.
  • For ages 50 and up the leading causes of death were: road injuries, suicides and tuberculosis.

More statistics

  • Most deaths caused by alcohol came from cardiovascular disease and cancer for all countries.
  • When you look only at drinkers, the standard recommendation of the American Heart Association regarding low alcohol consumption seems true. But the new study compared non-drinkers with drinkers. From this it is clear that even one drink a day has a risk of premature death.
  • At the age of 40 cutting down long-term alcohol use will add 1 to 2 years of life expectancy.
  • For all ages 2.8 million people die globally every year from alcohol related diseases.
  • Half of the world does not drink at all. This means that the ones, who drink, consume double as much as the statistics show.
  • Americans prefer beer. They drink about 27 gallons of beer, 2.6 gallons of wine and 2.2 gallons of spirits per adult/year.

Common clinical conditions from alcohol consumption

Binge drinking is the consumption of 5 drinks or more in an evening for men or 4 drinks for women. The CDC is concerned about binge drinking, because of its association with significant organ damages. There are 4 major concerns regarding these effects. Heart disease and cancer; diabetes; memory loss and appearance. In the following I will zero in on these alcohol-related conditions. 

Heart disease

As this article pointed out above, there is a very limited protective effect, but mostly in above 55-year-old women who drink in moderation (1 glass of alcohol; per day). They have some protection from developing heart attacks, because their LDL cholesterol gets lowered and their clotting system is influenced in positive ways. But 6% of breast cancer in women is due to the effect of alcohol consumption, which is a downfall. For both men and women binge drinking is what kills. Binge drinkers who drink more than 100 grams of alcohol per week (more than 7 drinks in the US) experience increased deaths. The causes are heart failure, strokes, fatal hypertensive disease and fatal aortic aneurysm, where the main artery bursts. Apart from that alcohol-related pancreatitis and liver cirrhosis can kill as well.

Cancer

A relatively new finding is that alcohol has a close relationship to causing various cancers. Alcohol weakens the immune system. Also, alcohol has a negative influence on the bacterial composition, the microbiome in our digestive tract, is. This can be a cause for colon cancer. Liver cancer, mouth cancer and breast cancer also has a direct relationship to increased alcohol consumption. Esophageal cancer and laryngeal cancer are also related to alcohol consumption.

Diabetes

Alcohol can stimulate the pancreas to release insulin, which may give you hypoglycemic attacks. As alcohol contains empty calories, over the course of several years alcohol consumption can add to your weight, causing obesity and type 2 diabetes. As diabetes has detrimental effects on the heart and blood vessels, this mixed with alcohol consumption, can worsen cardiovascular disease thus increasing the risk for heart attacks and strokes.

Memory loss

In the beginning of chronic alcohol consumption you may enjoy the relaxing effect of alcohol. This is merely the toxic effect of alcohol on brain cells. Alcohol has the effect of inhibiting brain cells, which makes you feel relaxed, super-sociable and even silly. In reality you are starting to loose control. After several years of this effect you are left with feelings of anxiety, depression and anger. This is when trouble starts to occur. People out of control are more likely to get into fights and get injured or killed. People can develop blackouts where they do not remember parts of the evening or an entire event. Memory loss is starting. The hippocampus is an important part of the brain that is involved in processing short- term memory into long-term memory. A form of dementia can occur that was brought on by chronic alcohol overconsumption.

Appearance

Alcohol dries out the skin cells and body cells. The face gets wrinkles. Your skin looks parched and gives you the appearance of a prematurely aged person. Alcohol can interfere with your sleep and when you have a lack of it you end up with dark circles around your eyes as well as puffy eyes. It does not make for a good picture, whether it happens inside the body or on your skin!

No Amount Of Alcohol Is Good

No Amount Of Alcohol Is Good

Conclusion

A new study that was larger and more comprehensive than any previous study has exposed the myth that one drink for women and two drinks for men would protect you from heart disease. It may protect you from heart attacks, but it definitely does nothing to protect you from other heart conditions. There is also sudden death from heart failure, a rupture of the aorta (aneurysm), high blood pressure that kills (fatal hypertensive disease) and stroke. When you factor all that in as well, even your low, moderate alcohol consumption has health risks. The global health study, funded by the Bill and Melinda Gates Foundation looked at the burden that alcohol puts on 195 countries. The combined study population was 28 million individuals.

Alcohol related deaths and diseases

649, 000 registered cases of various deaths occurred due to alcohol. This included deaths from traffic accidents, injuries, cancer, heart disease and suicide. This global study compared the life expectancy and disease frequencies of alcohol-consuming people with non-alcohol consuming people. It concluded that non-alcohol consuming people live on an average up to 10 years longer than their alcohol-consuming counterparts. No studies up to now have been that comprehensive. The results from twenty-eight million people speak for themselves, and the death statistics are clear. It is worthwhile to look at the details and draw your own conclusion.

Aug
25
2018

The Downside Of Living To 100

A review article has examined longevity and reviewed the downside of living to 100. In their 80’s about 10% of the population live in nursing homes, but among centenarians 55% are residing in nursing homes. They are often very lonely, as their social circles have shrunk as they aged.

Common diseases of older people

Osteoarthritis makes it difficult for people to get around, it causes chronic pain and it can also be the reason for falls. In 1990 there were 213.4 cases of osteoarthritis per 100,000. 26 years later, in 2016 there were 232.1 cases of osteoarthritis per 100,000 people.

Chronic obstructive pulmonary disease (COPD) has been falling, because less people smoke cigarettes now. Statistics show 1667 cases of COPD per 100,000 in 1990, but only 945 cases of COPD per 100,000 in 2016.

Diarrhea and common infections have dropped sharply from 8951 per 100,000 in 1990 to 3276 per 100,000 in 2016.

What other common diseases do older people get?

There are a number of common diseases that affect the elderly.

Osteoarthritis

Osteoarthritis of the hips and the knees are common, but it can affect every joint in the body. In the end stage knee replacements or hip replacements may be necessary. But before a total knee replacement or total hip replacement can even come into consideration, the person’s heart needs a thorough checkup to ensure that it is safe for the patient to undergo surgery under a general anesthetic.

Heart disease

Older people often have heart disease.

When coronary arteries are narrowed, heart attacks occur. Cardiologists can place stents, so that previously narrowed coronary arteries receive normal blood flow. Following such a procedure the patient may live for another 10 to 15 years.

There are also heart valve calcifications. The aortic valve is particularly endangered. A heart surgeon may be able to replace a diseased aortic valve by a porcine valve.

The nervous system of the heart transmits electrical signals from the sinus node to the muscle fibers, which can get diseased. Heart rhythm problems may necessitate the insertion of a pacemaker.

Finally, the heart may enlarge, but pump less blood than before. This condition is congestive heart failure. The 5-year survival for this condition is only 50.4%. Unfortunately there is very little the doctor can do for patients like this.

Cancer

The older we get, the more DNA mutations we accumulate. At one point cancer develops. If the diagnosis happens at an early stage there is a good chance that surgery can remove a cancerous growth, and the patient survives. But there are cancers that are notoriously difficult to recognize in the early stages. These are: cancer of the pancreas, kidney cancer, stomach cancer and certain types of leukemias.

Respiratory diseases

Those who smoked earlier in life may develop chronic obstructive pulmonary disease (COPD). It is a chronically disabling lung disorder. Often these individuals have to carry an oxygen tank with them wherever they go. The 5-year survival rate for people with COPD is 40 to 70%.

Osteoporosis

Osteoporosis is a disease where the bone is brittle. Spontaneous bone fractures can occur at the wrists, the upper thigh bone (femoral fractures) or in the vertebral bones. Women in menopause are hormone deficient and this contributes to calcium depletion of the bones. Lately research has shown that vitamin K2 and vitamin D3 are necessary for a normal calcium metabolism. Briefly, 200 micrograms of vitamin K2 and 5000 IU of vitamin D3 every day are the necessary dosage that the body can absorb calcium from the gut, eliminate it from the blood vessels and deposit it into the bone. Calcium is present in milk products and milk. If a person does not consume enough milk products a supplement of 1000 mg of calcium daily does make sense.

Alzheimer’s

The older we get, the more likely it is an onset of Alzheimer’s or dementia. Between the ages of 90 to 94 there is a yearly increase of Alzheimer’s of 12.7% per year. The group from age 95 to 99 years has a yearly increase of Alzheimer’s of 21.2% per year. Persons aged 100 years and older have an increase of Alzheimer’s by 40.7% per year. What this means is that essentially there is a doubling of Alzheimer’s every 5.5 years. We do not have all of the answers why this is happening and why Alzheimer’s develops. But we do know that diabetics are more likely to develop Alzheimer’s. High blood sugar levels and high insulin levels seem to lead to the precipitation of the tau protein in the brain, which causes Alzheimer’s.

Diabetes

When diabetes is not well controlled, there is accelerated hardening of the arteries. This can cause heart attacks and strokes. Longstanding diabetes can affect the kidneys (diabetic nephropathy, kidney damage) and can lead to hardening of the leg arteries. Often the only treatment left is a below knee amputation. Blindness from uncontrolled diabetes is common and pain from diabetic neuropathy as well.

Diabetics have an average life expectancy of 77 to 81 years. However, if they pay attention to their blood sugars and manage their diabetes closely they can live past the age of 85.

Falls and balance problems

As people age, their balance organ is not functioning as well. Also, people with high blood pressure medication may have postural hypotensive episodes that can lead to falls.

There may be a lack of cognitive functioning and misjudging of steps, ledges and irregularities in the floor. When a person has brittle bones from osteoporosis and they fall, a hip fracture is very common. At a higher age surgery for a hip fracture is dangerous. It can have a mortality of 50%.

Obesity

A person with obesity has a life expectancy that is 10 years less than a person without obesity. The reason for this is that with obesity This is so, because the risk of heart attacks, strokes, cancer, arthritis and diabetes is increased.

Depression

Older people often get depressed. It even has its own name: involutional depression. People can get into a state of mind, where they think negatively. Depressed people feel that they have nothing to live for. They lost friends; they are shut in because they can’t drive a car any more. This type of depression needs treatment by a psychologist or psychiatrist. The danger of leaving depression untreated is that the person may get suicidal. In older people depression is often precipitated by physical health problems.

Oral health

When teeth are not looked after, gingivitis and periodontitis can develop. Infected gums can shed bacteria into the blood and this can affect the heart valves. Endocarditis, the infection of heart valves, is a cardiological emergency. Prolonged antibiotic therapy is necessary to overcome this condition.

Poverty

Poverty has real consequences. The aging person may not have access to the optimal medical care facility because of a lack of funds. But even at a younger age there is evidence that people are healthier when they are wealthier.

Shingles

Older people often get shingles, even if they had chickenpox or shingles as a child. This is evidence that the immune system is getting weaker. Shingles in an older person should alarm the treating physician that there could be an underlying cancer. Due to that knowledge a cancer-screening tests should be part of the medical exam. In addition, a varicella vaccine should be offered to the patient to build up immunity.

The Downside Of Living To 100

The Downside Of Living To 100

Conclusion

Living to 100 is often glorified in the press. Maybe you have seen a 90-year old jogger completing a marathon, or you saw an 85-year old couple ballroom dancing. But what they don’t show you is what I summarized here, the less glamorous things about living to 100. You may get a heart attack or a stroke. Osteoarthritis may affect you how you walk. Congestive heart failure may make you get short of breath when you walk upstairs. Then there are various cancer types that are difficult to diagnose early.

If you have smoked in the past, you may suffer from chronic obstructive pulmonary disease (COPD), which leaves you breathless.

Other illnesses

Osteoporosis can lead to spontaneous fractures. Because the bone has a lack of calcium, this is difficult to treat and takes a long time to heal.

Alzheimer’s is ever so much more common when you approach the year 100. There are other medical conditions you can get: obesity, diabetes and depression. When you get shingles for the second time, it may mean that your immune system is getting weak and a cancer-screening test should be done.

There are some downsides when you approach the age of 100.

Know your risks and be vigilant

You may keep your physician busy checking out various age-related illnesses, but more importantly, get regular check-ups and tests. Any condition is easier to treat with an earlier diagnosis! The message for anybody reading this is very simple. Prevention through healthy living is something you can actively pursue. Keep your body and your mind busy. Enjoy time with friends and family instead of living a solitary existence. See the glass that is half full instead of viewing it as half empty. Stick to a healthy diet. Knowing all the risks is not a scare but a call to being vigilant. Knowledge is powerful and will help you to enjoy your golden years feeling well and happy.

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Aug
18
2018

Poor Diet Habits Can Cause Alzheimer’s

A new study from the Brock University in St. Catharine’s, Ont. showed that poor diet habits can cause Alzheimer’s. Specifically the risk for Alzheimer’s was a combination of high saturated fats in the diet in combination with too much sugar.

The third triggering factor was the normal aging process that also contributed to the development of Alzheimer’s.

The study showing that poor diet habits can cause Alzheimer’s

Master student Bradley Baranowski and PhD student Kirsten Bott conducted the experiments under the supervision of Assistant Professor of Health Sciences Rebecca MacPherson. The experimental group consisted of middle-aged mice that were observed for 13 weeks. They received a high-fat/high-sugar diet. The control group received a normal diet.

The experimental group with the high fat/high sugar diet was aging prematurely. They also showed elevated inflammatory markers, elevated insulin levels and cellular stress. Dr.MacPherson mentioned that the middle-aged mice would be comparable to humans aged 40 to 60. “[We’re] trying to see what the initiating signals are that can lead to progression of Alzheimer’s disease,” MacPherson said.

Lifestyle choices matter

“People often view Alzheimer’s disease as a genetic disease when in fact, genetic mutations leading to Alzheimer’s accounts for less than five per cent of cases,” Baranowski said in the press release. “This study highlights that our lifestyle choices matter and can potentially put us at risk of developing or progressing neurodegenerative diseases such as Alzheimer’s.”

Other studies that support the concept that lifestyles matter

Over the years many other researchers have analyzed what factors contribute to getting Alzheimer’s. It probably is a combination of several factors.

Age

Age is one of the major risk factors. Most Alzheimer’s patients are above the age of 65. Above 65 the risk doubles every 5 years. By the time we are 85 our risk is 1/3 to get it.

Family history

If you have a parent, brother or sister who came down with Alzheimer’s, you have a higher risk of getting it.

Environmental factors

Often environmental factors like eating too much sugar or too much saturated fat are confused with family history factors. Nutritional habits in a family can be like a tradition. It may appear as if this is a family history of Alzheimer’s when in reality poor eating habits were passed on from generation to generation. A lot more research is necessary in this area.

History of Head injury

A history of a closed head injury carries with it a higher risk of Alzheimer’s later in life. We need to use seat belts in cars and helmets when bicycling. Avoid risky sports activities where you would sustain a traumatic brain injury.

Heart disease

There is a link between heart disease, diabetes, stroke, high blood pressure, high cholesterol and Alzheimer’s. When brain arteries get clogged, the brain deposits more beta-amyloid protein as plaques. This is a sign of early Alzheimer’s disease.

Older Latinos and older African Americans

Older Latinos have a 1 ½-times higher risk than older whites to get Alzheimer’s and dementia. On the other hand older African-Americans are 2-times more likely than older whites to come down with Alzheimer’s. The reason for this is not entirely clear. But a big factor likely is the cardiovascular risk that is higher in Latinos and African Americans. This translates into a higher risk for Alzheimer’s.

Prevention of Alzheimer’s disease

There are more publications that point out that Alzheimer’s disease is largely preventable by cutting out those factors that contribute to its development.

Here is a list of steps to follow in order to prevent Alzheimer’s disease.

  1. First of all treat diabetes, high blood pressure and obesity aggressively. This eliminates cardiovascular risk factors, which keeps the brain vessels open.
  2. Furthermore quit smoking. By preserving the cardiovascular system the brain stabilizes.
  3. Another important factor is physical activity: exercise daily! This maintains cardiopulmonary fitness. It also keeps your brain vessels open.
  4. Also, take care of your diet: eat balanced meals and avoid junk food. A Mediterranean diet or the MIND diet are examples of diets that help prevent Alzheimer’s. Note that these are low sugar and low saturated fat diets. This fits the initial observation that you read in the beginning of this blog. Mice on a high fat/high sugar diet showed premature aging and developed Alzheimer’s. Knowing this, it is good to do the opposite: cut out excessive saturated fats and sugar. Sugar increase LDL cholesterol and triglycerides, which leads to hardening of arteries.
  5. Mental stimulation is another important factor for preventing Alzheimer’s. With lifelong bilingualism there was a delay of about 4.5 years in onset of dementia. The ACTIVE study is in the link above. It showed that mental stimulation could indeed delay the onset of Alzheimer’s over a 10-year period. 
Poor Diet Habits Can Cause Alzheimer’s

Poor Diet Habits Can Cause Alzheimer’s

Conclusion

Above all, I cannot emphasize enough how important a healthy diet is for a healthy mind. The combination of an overabundance of saturated fats and refined sugar was found to be the cause of premature aging in mice. But likewise, we know from human trials that this also causes premature aging in humans and higher incidence of Alzheimer’s. As a result, it is logical to recommend a lower intake of saturated fat and to reduce sugar intake. It will prevent hardening of the arteries and slow down the development of Alzheimer’s.

But there are many other recommendations to avoid getting Alzheimer’s: quit smoking. Stay physically active by exercising daily. Use a Mediterranean diet or the MIND diet to prevent Alzheimer’s. Clinical trials with these diets have shown them to be effective. Treat diabetes, high blood pressure and obesity aggressively as this will stabilize your metabolism. As a result it also prevents Alzheimer’s. Finally, stimulate your brain every day by doing various activities. This forms new synaptic connections inside your brain and postpones Alzheimer’s from setting in as you age.

Apr
28
2018

Animal Protein Is Bad And Nut Protein Good For You

Recently a study from California and France showed that animal protein is bad and nut protein good for you. This review goes back to  this original study from April 2, 2018.  Other studies have shown that there is a higher mortality with a meat-based diet.

How the study was done

Researchers followed 81,337 men and women from the Adventist Health Study-2 for a time of over 9.4 years. Between 2002 and 2007 they also researched the diet of the study participants. They used food frequency questionnaires. 2276 cardiovascular deaths occurred during the observation period. The risk for cardiovascular mortality regarding meat protein consumption was 1.61-fold. The cardiovascular risk for the nuts and seeds protein consumption group was 0.60. This means that the meat-consumers had a 61% higher heart attack and stroke rate. In comparison, the group that consumed nuts and seeds had 40% less heart attacks and strokes than people on a regular diet.

Discussion of the study

This study is rather large and went on for a long time (9.4 years). This gives the study great statistical power. The message from the study is quite clear. The more animal protein you eat, the higher your risk will be to succumb to cardiovascular disease. Having a heart attack or stroke prematurely will shorten your lifespan. In contrast, those whose protein source comes mainly from nuts and seeds are better off. They have a 40% lower probability to die from heart attacks or strokes.

Other studies regarding “animal protein is bad and nut protein good for you”

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Diabetes caused by red meats, processed meats, whole grains and sugar-sweetened beverages

A European study was analyzing risk foods that can lead to diabetes. https://www.ncbi.nlm.nih.gov/pubmed/28397016 The publication of the study was  in May 2017. Red meats, processed meats, whole grains and sugar-sweetened beverages caused a 3-fold higher risk to develop type 2 diabetes. This was compared to people avoiding those foods. Study participants consuming legumes and nuts had a low risk of developing diabetes. In between was a moderate risk group who ate refined grains, eggs, fruit, vegetables, dairy and fish. Consumption of risk-decreasing foods resulted in a 42% reduction of diabetes.

Foods that caused heart attacks and strokes

A March 7, 2017 study from Boston analyzed the key foods that cause increased mortality.  Intake of high sodium, highly processed meats, sugar-sweetened beverages and also unprocessed meats caused heart attacks and strokes. In addition, a lack of nuts/seeds, low consumption of seafood omega-3 fats, low vegetable and low fruit consumption also caused mortality from heart attacks and strokes.

Nuts reducing inflammatory biomarkers

A September 2016 study from Brigham and Women’s Hospital, Boston, MA looked at the correlation of nut consumption and an anti-inflammatory response. 5013 patients from the Nurses’ Health Study (NHS) and Health Professionals Follow-Up Study received food consumption questionnaires.

Research used two parameters for measuring inflammatory biomarkers: on the one hand blood tests checked the C-reactive protein (CRP), on the other hand they observed interleukin 6. Interestingly there was a correlation between nut consumption and decrease of inflammatory markers. When 5 or more helpings of nuts per week were part of the dietary habits, there was a 20% reduction in the CRP value and a 14% reduction of interleukin 6 , which was a difference to those persons who never consumed nuts. This is significant, because we know that inflammation of the lining of the arteries is a cause for high blood pressure, heart attacks and strokes. Inflammation of the arteries can also cause type 2 diabetes.

Dietary intake among US adults, 1999-2012

This June 2016 study has the title ”Dietary Intake Among US Adults, 1999-2012”. Comparisons were made between a previous dietary study of 1999-2000 and now. The investigators noted some improvements in dietary habits. The persons consumed more whole grains and nuts or seeds. They also had slightly increased fish and shellfish intake. On the other hand, consumption of sugar-sweetened beverages had decreased. But other food components like salt intake, total fruits and vegetables, processed meats and saturated fat had not changed. There was an increased consumption of whole fruit and a decrease of 100% fruit juice (which is sugar laden). Unfortunately there was also some bad news: low-income Americans still have poor food intake, so do non-Hispanic blacks or Mexican American adults.

Mediterranean diet can prevent cognitive decline

A July 2016 review shows that a Mediterranean diet can prevent cognitive decline like dementia and Alzheimer’s disease. In this overview the authors have collected evidence showing that adherence to a Mediterranean diet does indeed prevent cognitive decline. The Mediterranean diet consisted of intake of fruit, fish, vegetables and less consumption of sugar, red meat and dairy. The researchers found that the incidence of cancer, strokes, heart attacks and diabetes were all lower, as was dementia. They pointed out that MRI studies have revealed that the brain volume showed a reduction by 5% per decade after the age of 40. From the third to the 8th decade of our lives the short-term memory can show a reduction of about 50%.

Deterioration of general health related to cognitive decline

The authors point out that the combination of heart disease, stroke and diabetes are often an indication that the person’s overall health is declining. Cognitive decline will soon follow, when physical decline is evident. What people often do not realize is that all of these conditions are related to decades of poor diets. Change the diet to a Mediterranean diet, and your heart health will improve; also a stroke and diabetes may be prevented. The interesting observation is that often cognitive functioning also improves. This makes sense: if the brain circulation improves, oxygen and nutrients can reach the brain cells again and brain function can now improve.

Animal Protein Is Bad And Nut Protein Good For You

Animal Protein Is Bad And Nut Protein Good For You

Conclusion

I mentioned a recent publication, which stated that animal protein is bad and nut protein good for you. When I looked at other publications I found this confirmed. Finally I reviewed a study that investigated the use of the Mediterranean diet to improve cognitive function. It became apparent that physical illnesses, like heart attacks, strokes and diabetes, have also a connection to a loss of cognitive function in older age. It may point to a general aging of the lining of the arteries. An anti-inflammatory diet, like the Mediterranean diet, has the potential to improve the lining of the arteries. This leads to a reduction of medical problems like heart disease and diabetes. In addition it can also reverse cognitive decline. The switch to a Mediterranean diet is not dramatic! It can, however, dramatically improve your overall health and wellbeing as you age.

More info: https://www.askdrray.com/healthy-olive-oil/

Mar
17
2018

Benefits Of Hot Baths And Saunas

Don Benedict hurt his lower back and tells about benefits of hot baths and saunas to relieve his chronic pain. He is a 70-year old former handball player. He played competitive handball for 30 years in the Pacific Northwest. His story is reviewed here. In order to stay in shape, he ran 5 miles every other day. But at the age of 57 he ruptured a disc in his back. In the following years he ruptured several more discs and had three back surgeries for that. Eventually scar formation set in and no more surgery was possible. This left him with a chronic pain syndrome, for which he received prescriptions for strong pain medications. OxyContin, Tramadol and anti-anxiety pills were on his prescription list. He needed to take 14 doses of pills per day to control his chronic back pain.

Benefits of hot baths and saunas for chronic pain

Finally he remembered that as a younger man he was a summer river guide on Idaho’s Salmon River. When he and his wife had sore muscles they would relax in the hot baths of natural hot springs. Other people who visited these hot springs told him how having hot baths helped them for their aches and pains. For the past four years Don and his wife have been visiting the hot springs in Idaho City three times per week. This has decreased Don’s back pain significantly. He could reduce more than half of his pain medications and reduce the potency of the pain pills as well. The water temperature in the hot springs hovers between 97 and 99 degrees Fahrenheit (36 to 37 degrees Celsius). His wife, who has an asthmatic condition, reported that the hot soaks helped her muscle spasms around the throat.

Other treatment modalities to prevent chronic pain

13 years ago, when Don ruptured his first disc stem, cell treatments were not readily available. But if the same would happen today an unconventional stem cell therapy could be a treatment modality, and chronic pain could be avoided. I am mentioning this here, because Don’s suffering from chronic back pain was causing him a lot of unnecessary suffering. Discectomy surgery, which destabilizes the back and causes scarring, is not the first choice of treatment today.

Stem cell therapy

Instead stem cells are taken from the patient’s fatty tissue (liposuction) and from the bone marrow. A stem cell mix between bone marrow stem cells and mesenchymal stem cells (from fatty tissue) is made. Platelet rich plasma is added to this as an activator. The mix is injected into the disc space of the ruptured disc. Now the stem cells do their magic healing. The beauty of this medical procedure is that healing takes place without any scarring. The stem cells mend all of the damage. They do so by transforming themselves into identical body cells that overbridge broken tissues.

Benefits of hot baths and saunas for heart

  1. 2016 study published in the Journal of Physiology describes a study that included adults in their low twenties. Their arms were intermittently exposed to 40.5°C (105°F) water temperature for 60 minutes over a period of 8 weeks. This lowered their blood pressure and caused the arteries in the treatment group to be more flexible.
  2. Scientists in Finland have focused on the benefits of saunas, which is a Scandinavian tradition. Their study in the American Journal of Hypertension followed more than 1,600 middle-age men for almost 25 years. The results showed that the more the men visited saunas, the less they were suffering from high blood pressure. These were the statistics:
  • Visited sauna 2 to 3 times per week: 24% less likely to develop high blood pressure compared to those who had a sauna only once or not at all.
  • Visited sauna 4 to 7 times per week: 46% reduction of blood pressure.

Benefits of hot baths and saunas regarding dementia prevention

2016 study out of Finland found that frequent exposures to saunas could reduce the risk of developing dementia.

Compared to having a sauna only once per week (no reduction of dementia) these were some observations:

  • Visiting the sauna 2-3 times per week: 22% reduction of dementia.
  • Visiting the sauna 4-7 times per week: 66% reduction of dementia.

With regard to Alzheimer’s disease the corresponding figures were a 20% reduction and a 65% reduction.

Benefits of hot baths and saunas for brain injuries

Dr. Burke from the Emory University Rehabilitative Hospital is investigating the benefits of hot baths and saunas regarding brain-injured patients.

He recommends 4 saunas per week for brain-injured patients. Dr. Burke said: “This is one thing that’s passive and easier to do, especially in people who have injured joints who need to keep their brains and hearts in good condition, but can’t physically do some of the exercises.“

Caution regarding benefits of hot baths and saunas

Within 48 hours of a new injury, Dr. Burke says, it is best to use ice packs in order to reduce the swelling of the tissues. But subsequently he switches the patients to heat in form of saunas. Some patients have low blood pressure to start with. They may not be good candidates for hot baths as they may pass out when their already low blood pressure gets a further reduction. Always check with your own doctor before doing hot baths or saunas.

Europe’s history of hot baths and saunas

Saunas have a long history in Finland and in the rest of Europe.

Hot baths have a century-old history in Europe and Japan.

Father Sebastian Kneipp invented hydrotherapy, where cold and hot water baths are applied sequentially. The present resurgence of interest in the benefits of hot baths and saunas for healing purposes is nothing new. What may be new is that the medical profession at large is finally paying attention to the research of Father Sebastian Kneipp. He knew that there were benefits of hot baths and saunas.

Benefits Of Hot Baths And Saunas

Benefits Of Hot Baths And Saunas

Conclusion

There are benefits of hot baths and saunas. This is what was spelled out in the studies cited in this review. The fact that heat can heal was something that Father Sebastian Kneipp knew long time ago. Medical facts have a way to recirculate. But now we know that it can lower blood pressure and can improve the flexibility of arteries. It can help with tissue perfusion and reduce chronic pain. But it also prevents dementia and Alzheimer’s disease. In addition it helps patients with brain injuries to recover faster than without hot baths and saunas.

Advantage of heat treatments

The advantage of heat treatments is the fact that no side effects occur like with the use of drugs. Heat treatments are natural, but drug treatments are artificial. Hot baths and saunas can easily be part of one’s lifestyle. If you feel you need more of it, you can go ahead and do it, but if you feel you don’t need as much, use less. Make it fit into your lifestyle. It is also obvious that too much of a good thing is no longer a good approach to wellness. Limit the temperature in hot baths and don’t exaggerate the time you spend in a hot sauna.

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