Feb
06
2016

Effects Of Hormones On The Heart

Since February is heart month, I believe that this is a timely topic to understand how we can protect ourselves from heart disease. During the 23rd Annual World Congress on Anti-Aging Medicine on Dec. 11-13, 2015 in Las Vegas Dr. Ron Rothenberg gave a talk entitled ”Hormones And The Heart”. He stated that he wanted to give an overview of the effects on the endocrine system and on the cardiovascular system, in particular the effect of testosterone and estrogen. Also discussed were the effects of thyroid hormones, growth hormone, vitamin D and melatonin. In the following I will summarize what he explained in detail.

Testosterone treatment in men

He stated that there has been some confusion about the protective effect of testosterone on the heart in men. But Dr. Sharma and colleagues who investigated 83,010 male veterans with documented low testosterone levels clarified this confusion with this large study.

One group was given testosterone replacement therapy, another was not given replacement therapy and one group was given replacement with testosterone, but normalization of testosterone levels was not achieved.

The various groups were followed for between 4.6 years and 6.2 years. The results were astounding: When results between testosterone treated men were compared to non-treated men there was a 56% reduction of all cause mortality, a reduction of heart attacks by 24% and a reduction of strokes by 36%. There was no difference between the non-treated control group and the partially treated testosterone group where the testosterone levels did not come up. It is clear from this that with proper testosterone replacement where testosterone levels are monitored and corrected, significant reductions in strokes and heart attacks can be achieved. The explanation for these findings is simple: both, brain cells and heart cells in males, have testosterone hormone receptors that need to be stimulated for full function.

Hormone replacement in women

This topic has been clouded for many years because of the insistence of the medical profession to use horse derived estrogen (Premarin) and synthetic Provera (instead of bioidentical progesterone). These artificial hormone-like substances were used in the much-discussed Women’s Health Initiative (WHI).

Dr. Rothenberg said about this study that investigators used the wrong estrogen, the wrong progesterone, the wrong route of administration of estrogen (oral estrogen causes inflammation), and the wrong women at age 63 who already had cardiovascular disease and breast cancer.

One important aspect that was learnt by re-interpreting the WHI was that when estrogen replacement was initiated right away when menopause started, the heart attack risk went down by 34%. Estrogen and Provera together reduced the risk only by 28% (Provera being the wrong hormone). Again, the explanation for this findings is simple: women have both estrogen and progesterone receptors in heart and brain cells, which want to be stimulated with the natural hormones. When estrogen is missing, women need bioidentical replacement of what is missing with estradiol transdermal creams. When progesterone is missing, replacement with bioidentical progesterone transdermal cream or with micronized progesterone orally is needed.

Estrogen

With regard to estrogen replacement the KEEPS study has shed a new light on what is going on with hormone replacement in women.

This study was done on 700 women in early menopause. They were treated with 0.45 mg of Premarin (still the wrong hormone) or 50 micrograms of transdermal estradiol (the right active human estrogen). Women also received 200 mg of micronized progesterone (Prometrium, the real human progesterone) for 12 days each month. After 4 years of observation there was no case of breast cancer, uterine cancer, heart attack, transient ischemic attack, stroke, or blood clots in veins between the three groups. Both Premarin and transdermal estrogen had slightly reduced coronary artery calcifications on CT scans compared to the placebo group without hormones. The Premarin group increased the triglyceride and the CRP (a measure of inflammation) levels while the transdermal human estrogen did not do that.

Another study showed that due to the WHI study with the wrong synthetic hormones many women were fearful of starting estrogen replacement. The lack of hormone replacement with nature-identical hormones is responsible for the death of many women, who did not have the beneficial effects. They died of cancer and heart disease.

Dr. Rothenberg explained that this study and others have shown the following:

  1. Bioidentical hormone replacement must be started immediately at or before menopause to have the best results in terms of cardiovascular and neuroprotective (Alzheimer’s) prevention.
  2. Oral estrogen induces inflammation, which causes heart attacks, strokes and venous thromboembolism (blood clots). To prevent this, estradiol must be given as a transdermal cream. This will avoid the first pass effect through the liver, which is the cause for inflammation. Transdermal estradiol does not have the first pass effect. Inflammatory cytokines are implicated in autoimmune processes, initiation of cardiovascular disease, osteoporosis and Alzheimer’s disease.
  3. If estrogen replacement is not done right away with the start of menopause, the estrogen receptor may get damaged, which means that when estrogen replacement is started at a later date, it is no longer effective.

Progesterone

Progesterone is the other female hormone that is often overlooked. It balances the effects of estrogens, but it can also be metabolized into estrogen or testosterone. Tiny amounts of testosterone are necessary for normal libido. Progesterone production from the ovaries is already reduced when the woman is premenopausal and should be replaced by transdermal bioidentical progesterone cream.

Estrogen dominance needs to be treated with transdermal progesterone (or micronized oral progesterone). Both estrogen and progesterone can be accurately determined using a saliva hormone test. Blood tests are accurate for estrogen levels, but not for progesterone levels.

Thyroid replacement

Not infrequently thyroid tests are low (hypothyroidism) and cholesterol levels rise. This can lead to heart attacks and strokes. For instance, a slightly elevated TSH of 5.5 is associated with a total cholesterol level of 209 mg/dL, and a TSH level of 7.0 is associated with a cholesterol level of 270 mg/dL (normal less than 180 mg/dL). It is very important to detect hypothyroidism early and to treat it effectively to prevent cardiovascular disease. The active thyroid hormone is T3. Thyroid replacement has a stabilizing effect on the heart rhythm. It works together with testosterone in men and estrogen in women to stabilize metabolism of all cells, but in particular the heart muscle cells and brain cells. Hypothyroid patients are often depressed, but thyroid replacement lifts the depression. Cognitive deficits in patients with hypothyroidism are also remedied with thyroid treatment.

Growth hormone replacement

Growth hormone (GH) is important in childhood for bone growth and growth of all the organs. But GH still has an important function later in life. GH improves cardiac performance; it does so by thickening the wall of the left heart chamber, the main pump of the heart muscle. GH improves the contractility of the heart muscle, reduces the stress on the heart muscle wall and decreases vascular resistance. In animal experiments it was found that GH plays an important role in remodeling the heart after a heart attack.

GH deficiency occurs with aging; it leads to high LDL (bad) cholesterol and high triglycerides in the blood and increased fibrinogen, which causes blood clots. All of this increases the risk for heart attacks and strokes.

When people age, they lose GH production, which puts them at a considerable risk to get heart attacks and strokes, but they are also at a higher risk of serious falls due to muscle weakness and balance problems. When the doctor detects low IGF-1 levels in the blood and confirms low GH metabolites in a 24-hour urine sample, the time has come to do daily GH injections with human GH. This can be done using a similar pen that is used for insulin injections. The dosage is only between 0.1 mg and 0.3 mg per day, given before bedtime. This is remarkably effective not only for heart attack and stroke prevention, but also to treat muscle weakness, lack of mental clarity and general well being. Patients report that their joint and muscle aches disappear and they can engage in physical activities again.

Melatonin replacement

Melatonin is a hormone that is mostly thought of as the “sleeping hormone”. It is released by the pineal gland and rules overnight giving you a refreshing sleep. In the morning and during the day the light that enters your eyes inactivates it.

Melatonin is a powerful antioxidant, stabilizes the heart’s rhythm (anti-arrhythmic activity), is anti-inflammatory, anti-hypertensive and protects against heart attacks and strokes. People who have heart disease are usually found to have very low blood melatonin levels. Melatonin can be used intravenously in patients who have heart attacks to reduce the amount of damage to the tissue and stabilize the heart rhythm.

Like with GH, the production of melatonin deteriorates significantly beyond the age of 40. Blood levels of melatonin can be easily ordered, and replacement is easy to do. 3 mg of melatonin taken at bedtime will be a sufficient dose for most people. Another 3 mg can be taken, if you wake up in the middle of the night. It will wear off within 3 to 4 hours.

Vitamin D replacement

The history of vitamin D3 is interesting. Vitamin D3, the active form of vitamin D has many actions: it stimulates the immune system and reduces the risk of infection, it reduces blood pressure, it reduces inflammation by reducing circulating cytokines, and it increases insulin sensitivity making insulin receptors more responsive.

Vitamin D3 binds to the vitamin D receptor, which is contained on all cells.

Many middfle-aged and older people are deficient for vitamin D.  A lack of it leads to higher mortality. Vitamin D helps to restore circulation in patients with ischemic heart disease. Vitamin D insufficiency causes high blood pressure, diabetes and metabolic syndrome, enlargement and thickening of the wall of your heart’s main pumping chamber, heart failure and chronic vascular inflammation.

A prospective 7.3-year study looked at the hazard ratios of the Third National Health and Nutrition Examination Survey (NHANES III) and linked mortality files with lower 25-hydroxyvitamin D levels. There were 33,994 persons part of the survey, of whom 1,493 died.

Below 10 ng/ml of 25-hydroxyvitamin D level the mortality was 2.5 fold for all causes and 3.08-fold for cardiovascular causes compared to those with levels of 100 ng/ml or higher.

The recommendation presently is to maintain serum levels at 60-80 ng/ml of 25-hydroxyvitamin D to prevent cardiovascular disease.

Effects Of Hormones On The Heart

Effects Of Hormones On The Heart

Conclusion

The following is important to remember regarding prevention of heart disease.

  1. Never smoke or if you do, quit smoking.
  2. Have your thyroid hormones checked as thyroid hormones are important as an energy source for your heart muscle, and they lower LDL cholesterol levels.
  3. Your sex hormones matter: in men it is testosterone, in women estrogen and progesterone that support your heart.
  4. Vitamin D is not only important when we grow bones as youngsters, but it continues to be important when we are older. It supports our heart and other body functions. It is an essential team player, as it prevents premature deaths. Blood levels of vitamin D are easy to measure.
  5. Two hormones leave us rapidly as we age: melatonin and human growth hormone. However, levels of both hormones can be measured and if low, they can be replaced.
  6. There are only two more things you need to do: eat a Mediterranean type diet and exercise on a regular basis. This will ensure your heart is still healthy in years to come.

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Jan
31
2016

The Gut and Brain Connection

At the 23rd Annual World Congress on Anti-Aging Medicine (Dec. 11-13, 2015) in Las Vegas there were several lectures pointing out the importance of the gut flora for proper brain function. If you have the wrong gut flora, you can get a number of diseases like diabetes, fibromyalgia, rheumatoid arthritis, multiple sclerosis, muscular dystrophy, some cancers and even obesity. Martin P. Gallagher, MD, DC talked about this in his talk “Gut on Fire, Brain on Fire!”

Function of the microbiome

The microbiome is the sum of all microbial organisms inhabiting the human body, which colonize mainly the colon, but also to a lesser degree the small intestine. Dr. Gallagher stated that the microbiome weighs only 7.1 oz., although in the past have some have estimated its weight to be as high as 3 pounds. The purpose of the microbiome is to help form a gut/blood barrier. It forms a 30-micron thick layer in the GI tract, protects the intestinal lining and metabolizes food remnants, especially from carbohydrates. It also communicates with the immune system. There is a cross talk between the lining of the gut and the and the body’s immune system. The gut bacteria help the body to create stability; they also decrease intestinal permeability.

When inflammation occurs in the gut, the thickness of the biofilm is less than 30 microns. Intestinal permeability increases, which is called “leaky gut syndrome”. This can be the cause of autoimmune diseases and possibly other diseases.

The enteric nervous system

The gut can produce as many neurotransmitters as the brain and spinal cord can synthetize. The enteric nervous system communicates with the brain through the vagal nerve. Serotonin is an important neurotransmitter that has been found to regulate motility of the gut. The control system of the gut can work on its own and override the concerns of the central nervous system.

Parkinson’s disease is a disorder of the enteric nervous system as well as the brain. With Alzheimer’s disease the characteristic lesions found in the brain are also found in the enteric nervous system!

In a mouse experiment a Lactobacillus strain known to be part of the microbiome was shown to heal anxiety and depression related changes in certain parts of the brains of these experimental animals. But when the vagal nerve of these animals was severed, none of these healing changes occurred. This suggests that the gut bacteria are able to communicate to the brain via the vagal nerve. Researchers have coined this connection the “gut-brain axis”. These protective gut bacteria have the ability to protect humans from gastric acidity, from bile acid toxicity, they adhere to the lining of the gut and they persist to reside within the gastrointestinal tract. Probiotics help the immune system to maintain the immunologic memory and to secrete antibodies, called immunoglobulins.

Two strains with benefit to humans are Lactobacillus rhamnosus GG and Saccharomyces boulardii. Probiotics often help against diarrhea. The natural food for gut bacteria in the colon comes from starches of chicory, asparagus, inulin and onions that are indigestible in the stomach and small intestine, but are fermented in the colon to provide food for the bacteria residing there.

Small Intestinal Bacterial Overgrowth (SIBO)

Overgrowth of the small intestine with bacteria that produce endotoxins appears to have significance in both animal models and human disease. Chlamydia species as well as Borrelia burgdorferi (Lyme) can produce toxins that cause hypersensitive of pain in soft tissues in fibromyalgia and animal models of fibromyalgia. SIBO-small intestinal bacterial overgrowth- in experimental animals caused the same hypersensitivity of the soft tissues and also leaky gut syndrome.

Risk factors for SIBO

What causes SIBO is too little stomach acid production, treatment with proton pump inhibitors (powerful anti acid medications) and antibiotics. According to Dr.Gallagher SIBO also occurs in postsurgical patients, in patients with diabetes, and is brought on by alcohol, nicotine, drugs and GMO foods.

Neurogenic inflammation

Normally the blood brain barrier keeps immune cells from the body out of the brain. Only glucose, proteins and lipids are allowed into the brain, but not lipophilic neurotoxins. Neurogenic triggers, when admitted to the brain, will compromise the function of the immune cells of the CNS, called microglia. This can result in memory loss, Alzheimer’s, dementia, seizures, migraines, Parkinson’s Disease, multiple sclerosis, cancer, weakness, numbness, etc.

What triggers inflammation?

Here is a long list of different items that cause inflammation: aging, hormone deficiencies, obesity, diabetes mellitus, cardiovascular disease, fungal infection, the Standard American diet (SAD), pain, trauma and mechanical stress, heavy metals, food allergies, toxins, gut dysbiosis, small intestinal bacterial overgrowth, mal-digestion/absorption, prescription drugs, over-the-counter drugs, recreational drugs and alcohol, lack of exercise and lack of sleep.

Neurotoxic insults start the chain of reactions (heavy metals, nutritional deficiencies, viruses/fungus/bacteria, inflammatory diet, MSG, solvents, pesticides, herbicides, etc.): one or more of these factors destabilize the tight junctions of the blood brain barrier, which leads to neurogenic inflammation. The result is Parkinson’s disease, MS, dementia, chronic pain, behavioral and personality changes, Alzheimer’s disease, ALS and Lyme disease.

What seems to be happening a lot is that there is overgrowth of abnormal bacteria in the small bowel, which produce toxins. These in turn lead to leaky gut syndrome, which allows neurogenic triggers to attack the blood brain barrier. From here it is a short step to neurotoxic insults of the brain overstimulating the microglia, which will produce the diseases listed above.

Healing of brain inflammation

Treatment starts with the Mediterranean diet, which has been shown to have anti-inflammatory properties. People who are gluten sensitive need to eliminate gluten entirely from their food; casein sensitive people need to eliminate dairy products. A triple strength, molecularly distilled fish oil product is taken as a supplement every day with 4 grams or more of DHA/EPA.

Glutathione: One of the most powerful antioxidants and anti-inflammatories is intravenous glutathione. This is given as intravenous chelation therapy, which removes heavy metals. Other chelation agents such as EDTA intravenously may be given alternatively. Dr.Gallagher said that glutathione serves as primary cellular defense against free radicals, is a powerful antioxidant and serves as detoxifying agent against xenobiotics. Xenobiotics are remnants of artificial fertilizers, pesticides and pollutants that are contained in crops we eat.

Dr. Gallagher gives 600mg of glutathione twice per day intravenously for 30 days. In Parkinson’s disease patients whose mid brain is often poisoned by mercury this leads to 42% decline of disabilities and the effect last for 2 to 4 months after this treatment has been stopped. This treatment also protects telomeres, the caps on the ends of cellular DNA as well as mitochondrial DNA. Glutathione is protective of neurons and nerves.

Curcumin: this common Indian spice, found in turmeric is a potent anti-inflammatory. It is a safe natural agent and has also anti-viral and anti-tumor activities. It binds to the vitamin D receptor and works synergistically together with vitamin D3. Solid lipid curcumin particle technology makes curcumin 65-fold more bioavailable; free curcumin is allowed to pass the blood brain barrier. Lower doses achieve the same effect than regular curcumin.

According to a publication using lipidated curcumin the following observations were made: improved vascular function, inflammatory markers reduced by 14%, triglycerides lowered by 14%, oxidative stress reduced, catalase increased and total antioxidant status improved.

Omega-3 fatty acids: omega-3 fatty acids are anti-inflammatory by countering the arachidonic acid pathway that leads to inflammation. It is best administered as triple strength, molecularly distilled fish oil. DHA/EPA are the active ingredients. Chronic inflammation requires 2 to 12 grams daily; irritable bowel syndrome 6 to 12 grams daily; depression, anxiety and insomnia require 2 to 4 grams per day; autoimmune disease, back pain and degenerative joint disease 4 to 12 grams per day.

Gut/brain dysbiosis: For gut/brain dysbiosis Dr. Gallagher recommended to start with a 10-day fruit/vegetable detox program. Milk thistle, glutathione and pancreatic enzymes are used in combination. Lipidated curcumin. Glutamine, prebiotics and probiotics are given for gut support. Molecularly distilled fish oil (DHA/EPA) and vitamin D3 are given as anti-inflammatories. Oral and intravenous glutathione is given to detoxify. Antifungals are given as a combination of glutathione, oregano, olive leaf and silver salts.

The Gut and Brain Connection

The Gut and Brain Connection

Conclusion

Inflammation can start in the gut, lead to leaky gut syndrome and break down the blood/brain barrier. The end result is that the brain also gets inflamed and Alzheimer’s disease and dementia can occur. The sooner treatment is begun, the faster the recovery will be. When the end stage is reached, it is difficult to turn the inflammatory process around. Fortunately there are effective ways to get the inflammation under control with intravenous glutathione in the beginning and subsequent treatment with lipidated curcumin, omega-3 fatty acid and vitamin D3. A permanent switch to a Mediterranean diet is important as well to keep inflammation under control.

A few years back this type of approach would have been considered as “quackery”; now it is the latest information from research into the brain/gut connection. A lot can be done on a preventative basis with lifestyle and nutrition choices. Treatment is possible, but once full-fledged disease is established, a full cure may not be possible.

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Nov
28
2015

Diet And Brain Health

The fact that the type of diet you eat has a lot to do with your brain health keeps popping up in the medical literature, and this year has not been any exception.

The Mediterranean diet in particular has been shown to have very positive effects on postponing Alzheimer’s disease by as much as 5 years.

A clinical study on 674 elderly patients (mean age 80.1 years) without dementia, was published in the journal “Neurology”. It examined the question whether adherence to the Mediterranean diet would affect the degree of brain atrophy, which in turn is known to correlate with the onset of Alzheimer’s disease.

The findings were interesting: a high adherence to the Mediterranean diet led to a higher total brain volume, total grey matter volume and total white matter volume as measured with high-resolution structural MRI scans. Lower meat intake led to higher brain volume and more fish intake caused the mean cortical thickness of the brain to increase. Parts of the brain that are affected in Alzheimer’s patients with atrophy like the cingulate cortex, parietal lobe, temporal lobe, and hippocampus showed good volumes with the MRI scans when patients adhered to the Mediterranean diet. These volumes started to shrink when the diet was poor.

Those who adhered to the Mediterranean diet have brains that on MRI scan look 5 years younger and are much less likely to get affected by Alzheimer’s disease. Physicians have known for a long time that people, who eat a healthy diet, exercise regularly, don’t smoke and who keep mentally stimulated will generally have healthier brains than people who don’t do these things.

What is the Mediterranean diet?

It involves eating meals that are made up of plants: vegetables, fruit, cereals, beans and nuts. You can eat fish and poultry twice per week. You cut down the amount of meat and dairy you eat, but you can have a glass of wine per day, if you like. Butter is not used for cooking, but olive oil is used instead. Here is more information of what is included in the Mediterranean diet.

Because there is less fat and less high glycemic index carbs in this diet, it is also a diet that lends itself for weight management. You shed a few pounds and reach your ideal body mass index without paying much attention to this.

Apart from the Mediterranean diet another diet, called the MIND diet has also been shown to prevent brain atrophy. This diet is a combination of the DASH diet that was developed for controlling high blood pressure and the Mediterranean diet.

The Mediterranean diet makes you live longer

The Nurses’ Health Study that has been going on since 1976 showed that telomeres, the caps on chromosomes, were getting shorter in nurses who lived on junk foods, but surprisingly nurses on the Mediterranean diet preserved their telomeres. Longer telomeres are associated with slower aging. And people with longer telomeres reach an older age without diseases like heart attacks, liver disease or cancer.

Exercise on top of the Mediterranean diet

It is not a good idea to just rely on a healthy diet, like the Mediterranean diet to prevent heart attacks, strokes and other diseases. You need regular exercise as the other ingredient to keep you well. When you combine exercise with a healthy diet your abdominal girth shrinks as this study showed.

Another study showed that when a Mediterranean type diet is combined with regular exercise, adult onset diabetes occurrence could be reduced by 28-59%.

This is quite a significant effect of two simple interventions: a healthy diet and regular exercise.

Don’t smoke

It does not make sense to go on a healthy diet, exercise and then smoke! Interestingly an Iranian study showed that when people became health conscious, adopted a healthy diet and exercised, they also started to quit smoking. People who did all of this, quit smoking, eating healthy and exercising regularly, were also the happiest and most content.

Exercise your brain

The evidence shows that any stimulation of brain activity, particularly anything that requires active and abstract thinking will protect the brain from developing Alzheimer’s disease.

Another study showed that prevention of Alzheimer’s disease is achieved by quitting smoking, treating high blood pressure, stimulating the brain and treating diabetes.

Diet And Brain Health

Diet And Brain Health

Conclusion

Although the focus here was on diet and brain health, the most success is achieved by following a comprehensive program that involves a review of your lifestyle. This approach will be the most successful way to prevent Alzheimer’s disease. It starts with quitting smoking. It goes on to starting a Mediterranean diet and staying on it. Regular exercise will take care of preventing heart attacks and strokes, but exercise also ensures that all of your brain cells continue to get oxygen and nutrients, which in turn prevents brain shrinkage. Because the Mediterranean diet has a lower calorie content than the Standard American diet, there will be weight loss until you reach your ideal body mass index. Stimulating your brain by actively working with the computer, doing puzzles, playing a music instrument, phoning friends, reading books etc. will all contribute to preventing Alzheimer’s. Watching TV or movies is not an active mental activity, it is passive thinking, which means it is not as valuable as the other activities. Pick a hobby that enhances your life, and your brain will thank you for it too!

Nov
10
2015

Sugary Soda Drinks Make You Sick

Dr. Frank Hu and colleagues have recently re-examined the old question of what sugary soda drinks do to you. They usually contain high fructose corn syrup, a mixture of 55% fructose and 45% glucose. This sugar mix can be found in sugary soda drinks as well as in many processed foods like fruit spreads. Dr. Hu’s publication is listed in PubMed , but details can be found in this summary.

The study found that one or two cans of sugary soda drinks per day lead to

  • As high as a 26 percent greater risk of developing type 2 diabetes,
  • A 35 percent greater risk of heart attack or fatal heart disease, and
  • A 16 percent increased risk of stroke.

The study also found that there is a difference of how glucose, the main sugar that the body uses for energy is metabolized versus fructose from high fructose corn syrup or the breakdown of table sugar, a disaccharide consisting of glucose and fructose combined as one molecule. Glucose gets directly absorbed from the gut into the blood circulation and with the help of insulin gets further absorbed directly into body cells. In contrast the liver metabolizes fructose into triglycerides, which can cause fatty liver disease and also insulin resistance. Fructose also raises the bad cholesterol (LDL cholesterol). This in turn is a risk factor for developing diabetes, heart attacks and strokes.

It is fructose in sugary drinks and processed foods that are largely responsible for weight gain, metabolic syndrome, diabetes and cardiovascular disease.

The newest finding: heart failure can also be caused by high fructose corn syrup

A study in Sweden has recently shown that sugary drinks can cause heart failure. 4200 Swedish men were followed for 12 years in regards to food habits. The study found that the men who drank at least two sweetened drinks per day had a 23% higher risk of developing heart failure. Dr. Susanna Larsson, a co-author of the study, said: “The takeaway message is that people who regularly consume sweetened beverages should consider limiting their consumption to reduce their risk of heart failure”. Heart failure affects nearly 6 million Americans. It develops either on its own in persons with inadequately treated high blood pressure or in people who had a previous heart attack. It is a condition, which disables the heart to effectively pump enough blood with nutrients and oxygen into the tissues. People who are affected by this condition feel the symptoms: they get short of breath with minimal activity. They also may wake up short of breath in the middle of the night. It is a miserable life, as people with heart failure are severely limited in their activities. Even walking a flight of stairs becomes a struggle or even an impossible task. Total disability is the next step.The key is prevention: do not use high fructose corn syrup, and stay away from sugar in any form; instead use stevia to sweeten your food when needed.

Be careful how you replace saturated fatty acids

Dr. Frank Hu has also participated in a study that spanned over 24 to 30 years and examined the replacement of saturated fat with polyunsaturated fatty acids (PUFA), monounsaturated fatty acids and whole grain carbohydrates. The study involved 84,628 women (Nurses’ Health Study, 1980 to 2010), and 42,908 men (Health Professionals Follow-up Study, 1986 to 2010). The diet was assessed with detailed questionnaires every 4 years. 7,667 cases of cardiovascular disease (CHD) occurred during the long observation times. Compared to controls that did not change their diet with respect to saturated fatty acid intake, those who replaced with PUFA had 25% less CHD, those who replaced with monounsaturated fatty acids had 15% less CHD and those who replaced saturated fatty intake with whole grains had 9% less CHD. In contrast, a subgroup that had replaced saturated fatty acid intake with carbohydrates from refined starches/added sugars ended up with a 10% increase of CHD.

Cutting fructose out of diet lowers cholesterol and weight

A new study by Dr. Robert Lustig and colleagues from the University of California, San Francisco showed on 43 children that a change of diet reducing dietary sugar from 28% to 10% and replacing it with other complex carbohydrates led to a significant reduction in triglycerides, cholesterol and blood pressure.

The fructose stimulus was taken away, which stimulates a part in the brain, called nucleus accumbens, where the reward center is located. This is the reason why the more sugar you take in, the more addicted to sugar you become. Not surprisingly when the diet was changed, there were not only internal signs of improving with regard to blood tests, but physically the children showed weight loss just within 10 days as their total calorie intake had reduced. Another observation with regard to fructose metabolism is that ghrelin, the hunger hormone, which usually gets suppressed after a meal, will not get suppressed when you drink a sugary drink with fructose in it. The result is that you do not feel satisfied and you keep on consuming fructose containing drinks resulting in weight gain.

Sugary Soda Drinks Make You Sick

Sugary Soda Drinks Make You Sick

Conclusion

What we eat matters in terms of long-term consequences. This has been shown with refined sugar intake. Don’t lull yourself into the belief that honey is “healthy”. Even though it is a natural product, your body treats it according to its chemical composition: it is sugar, and unfortunately it will get you into health problems naturally. The currently fashionable agave syrup is largely composed of fructose: again, this is bad news for your health! No matter what type of sugar you choose, the long-term consequences have haunting qualities. Consequences of sugar intake are weight gain, diabetes, heart attacks and strokes. When you look at this, you will agree that is not worth to take any of these risks just to satisfy a sweet tooth. Biting into a crisp, sweet apple is enjoyable and has never harmed anybody. Eating a small helping of fruit salad to top off a meal can be a delicious finale to dinner. If you need a sweetener, you are better served using the plant-derived stevia, which is available as a powder or a liquid. Smallest quantities are adequately sweetening foods. Stevia has no calories and none of the consequences of sugar: you’ll enjoy the sweetness without the bitter aftereffects of tooth decay or heart disease!

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Oct
17
2015

Depression Needs Treatment

Depression is common: 10% of all men and 20% of all women have a period of depression in their lives. In people with medical illnesses depression is more common: 20% to 40% (Ref.1).

The peak age for depression is usually the age of 25 to 44. There are special groups where depression is also common. In adolescents 5% are affected with depression and 13% of women tend to get depressed after delivery, a condition called postpartum depression.

In any age group with depression there is a risk of suicide, but with adolescents this is particularly true.

About 10% to 15% of people with general medical illness are developing depression, such as patients with Parkinson’s disease, stroke, Alzheimer’s disease, cardiac disease, HIV infection, end-stage renal failure and cancer.

Causes of depression

Officially it is not known what causes depression. That is what medical textbooks say. However, other books like Datis Kharrazian’s book “Why isn’t my brain working?” offers several scenarios that can cause depression and he has examples of cases that were cured of depression (Ref.2). He points out that deficiencies in two major brain transmitters can cause depression: serotonin and dopamine.

  1. Serotonin is produced in the midbrain from the amino acid tryptophan in two biochemical steps. These biochemical conversions require iron, vitamin B6, vitamin B12, niacin, folic acid and magnesium as co-factors. But you also need the “large neutral amino acid transporter” (LNAA) to transport tryptophan through the blood/brain barrier into the brain.
  2. Dopamine is a neurotransmitter that is produced in the frontal lobes of the brain. It is also necessary for learning. Dopamine is synthetized by the brain from tyrosine, which has to be manufactured in the liver from the amino acid phenylalanine. You need to have a healthy liver to produce tyrosine, which needs to be transported through the blood/brain barrier into the brain; similar to tryptophan this requires the “large neutral amino acid transporter” (LNAA). People with hepatitis, fatty liver, insulin resistance or diabetes may have problems with the LNAA transporter, which can cause dopamine deficiency (Ref.2). But as mentioned earlier they may also have low serotonin because tryptophan was not transported into the brain. This will happen with sugar overconsumption, as insulin resistance develops and affects the LNAA transporter resulting in both low serotonin and dopamine (Ref.2).
  3. Since the 1990’s it is known that inflammation is also a possible factor in the causation of neurological disease including depression. Ref. 2 points out that gut issues can become brain issues as inflammatory substances can leak trough a leaky gut into the blood stream and trough a leaky blood/brain barrier into the brain. Hypothyroidism can activate brain inflammation and lead to an imbalance of the neurotransmitters. Gluten sensitivity is also an important cause of depression through the inflammatory connection, but few physicians recognize the full impact of this.

Tests for depression

There are no laboratory tests that would define depression. However, every patient should be checked for hypothyroidism, a common cause of depression. If hypothyroidism is found, this can easily be treated by thyroid hormone replacement.

Otherwise the diagnosis of depression is made based on mental status examination, history and review of symptoms. A good start is to ask: “In the past 2 weeks how little interest or pleasure in doing things have you had?” and “Have you been feeling down, depressed, or hopeless in the past 2 weeks?” (Ref.3).

There are detailed psychometric questionnaires available such as the Beck Depression Inventory that can assist the physician to establish the diagnosis.

Myths of depression

One of the myths regarding depression is that it would be contagious. A study on 2000 high school students showed that depression was not infective. The contrary was true: human interaction with friends who had a “healthy mood” improved depression. By the same token, when you constantly compare yourself with your Facebook friends, and you are not in the best mood, your mood may worsen and you could become depressed.

Treatment of depression

Despite advances in the treatment of depression the response rate with antidepressant therapy is limited to 60% to 70%. According to Ref.4 inadequate dosing and misdiagnoses account for the fact that 30% to 40% of treated people with depression have treatment failures. Typically the first antidepressant involves a selective serotonin reuptake inhibitor (SSRI), but newer trials have shown that the older monoamine oxidase inhibitors (MAOIs) have a higher success rate when treating depression initially (Ref.4).

A good antidepressant for mild to moderate depression is St. John’s wort, which is recommended by Ref. 5 as having less side-effects as other antidepressants.

In treatment resistant depression the psychiatrist often employs other combinations of antidepressants. In addition cognitive/behavioral therapy is added, which makes the overall treatment more successful. It goes without saying that complicated cases of depression belong into the hands of an experienced psychiatrist.

Suicides

Unfortunately there is still a stigma attached to have a mental disease like depression and people are in deep denial. Friends who do not understand depression may inadvertently say things that make the symptoms of the depressed person more severe and distance themselves at a time when they would need support from friends. The end result is loneliness, feelings of being misunderstood and having suicidal thoughts. Often it is men who will resist seeking treatment for depression, women are better in getting treatment started.

This is where a psychiatrist needs to intervene. If this does not happen, people start attempting suicide and finally commit suicide. In the US committed suicides have a gender ratio of male to female of 3:1 to 10:1. These situations become very difficult. The family needs to step in and talk to the patient. It is best to accompany the patient to the hospital for an assessment. Going to the hospital may be done privately or by ambulance. Don’t be shy to call 911 for an ambulance. Better to be cautious than have a major crisis that ends in completed suicide.

Alternative depression treatments

There are alternative treatments for depression.

1. Magnetic therapy for depression: This therapy is also called transcranial magnetic stimulation (TMS) and was approved for Canada and in 2008 by the FDA.

But it is not as powerful according to Ref. 3 as unitemporal electroconvulsive therapy.

2. Bifrontal electroconvulsive therapy (ECT): Electroconvulsive therapy with two pedals applied to the front of the skull appears to have the best results in terms of treating depression.

3. Omega-3 fatty acids (EPA and DHA) are powerful anti-inflammatory agents, which will take care of the inflammatory component of depression. Both fish oil and krill oil in combination give the optimal response as outlined here.

4. Vitamin D3 is also anti-inflammatory and will contribute to an improvement with existing depression, but it also helps prevent the development of depression when taken in regularly as a supplement.

5. Light box therapy: The observation of seasonal affective disorder (SADS) can develop as a result of lack of light. This has led to the discovery that light boxes are helpful for treating depression and also for prevention of depression due to seasonal affective disorder.

A light box should be used for 30 minutes every morning during the fall and winter months. The box should emit at least 10,000 lux. Improvement can occur within 2 to 4 days of starting light therapy, but often it takes up to 4 weeks to reach its full benefit.

6. It is known for a long time that alcohol is a depressant; it can actually cause depression and in persons with bipolar disease it can trigger a flare-up of that disorder as well.

7. Finally it matters what you eat: sugar and too much starchy foods (high glycemic index carbs) lead to insulin overproduction and insulin resistance. This causes inflammation, and this will cause depression. As mentioned earlier it also lowers the two key brain transmitters, dopamine and serotonin.

The solution is an anti-inflammatory diet, the Mediterranean diet without sugar and high glycemic index carbs; only low glycemic index carbs are allowed. This will normalize insulin production and eliminates inflammation.

8. Vitamin supplements: Folate and vitamin B12: Up to 1/3 of depressed people have folate deficiency. Supplementation with 400 mcg to 1 mg of folic acid is recommended. Vitamin B12 should also be taken to not mask a B12 deficiency (Ref.5). Folate and vitamin B12 are methyl donors for several brain neuropeptides.

9. Electro acupuncture has been shown in many studies to be effective in ameliorating the symptoms of depression and seems to work through the release of neurotransmitters in the brain (Ref.6).

10. Exercise on a regular basis helps to equalize the mood and seems to exert a slight anti-depressant effect on the person who engages in regular physical activity.

Depression Needs Treatment

Depression Needs Treatment

Conclusion

I have attempted to show the complexity of depression and what is known about its causes and treatment. Very likely there are several causes for depression and further research will hopefully bring more clarity to this. Treatment modalities, both conventional and unconventional have been developed over the years by trial and error. The physician and patient need to use common sense: if a treatment is working, stick to it and use it. If it does not work, move on and try something else. More difficult cases should be referred to a psychiatrist who has the most experience with difficult to treat cases. Do not neglect life-style factors and alternative depression treatments as they can often help to stabilize depression significantly. We all must be vigilant about suicide risks in depressed patients and act by calling 911, if necessary to intervene.

More info on depression: http://nethealthbook.com/mental-illness-mental-disorders/mood-disorders/depression/

References

1. Depression, Major: Fred F. Ferri M.D., F.A.C.P., Ferri’s Clinical Advisor 2016, by Elsevier, Inc.

2. Dr. Datis Kharrazian: “Why Isn’t My Brain Working?” © 2013, Elephant Press, Carlsbad, CA 92011

3. Goldman-Cecil Medicine “Major depressive disorder” 2016, by Saunders, an imprint of Elsevier Inc.

4. Massachusetts General Hospital Comprehensive Clinical Psychiatry, Second Edition: Theodore A. Stern MD, Maurizio Fava MD, Timothy E. Wilens MD and Jerrold F. Rosenbaum MD © 2016, Elsevier Inc.

5. Rakel: Integrative Medicine, 3rd ed. © 2012 Saunders.

6. George A. Ulett, M.D., Ph.D. and SongPing Han, B.M., Ph.D.: “The Biology of Acupuncture”, copyright 2002, Warren H. Green Inc., Saint Louis, Missouri, 63132 USA

Sep
25
2015

Testosterone

One of the driving hormones in a man is testosterone. It also is known that with age testosterone levels fall. The lesser known fact is the importance of monitoring testosterone levels in aging males, so they have the choice of intervening with the aging process. Here are the facts about testosterone, about replacement of testosterone and about the anxieties of the medical profession to deal with this.

Androgen receptors contained in key tissues

Androgen receptors are situated in the key organs like the brain, heart, muscles, bones, kidneys, fat cells, genitals, hair follicles and skin. They respond to all male hormones, called androgens, like testosterone, dihydrotestosterone (DHT) and DHEA. DHT is produced by metabolizing testosterone with the help of an enzyme, called 5α-reductase in the adrenal glands. This is responsible for hair loss in males and some females. There is a genetic factor for this. It is important that the man continues to have all tissues stimulated by testosterone when he ages or the key organs mentioned are going to suffer.

A lack of testosterone as the man ages (around 55 to 65) leads to a slowdown in thinking, osteoporosis in the bones, muscle atrophy (melting in of muscle tissue), and a lack of sex drive. Mood swings can turn the male into the “grumpy old man”. The skin gets thinned and is more brittle.

Animal experiments have shown that the development of fatty streaks in blood vessels happens at a higher rate in castrated animals. The more encouraging finding in these animals is the fact that this condition is reversible by replacement of testosterone. In healthy males of a younger age all organs are working well. The problems starts when males age and the hormone regulation in the brain slows down, which ultimately leads to andropause in males, the equivalent of menopause in women. When testosterone is replaced in an aging man with low testosterone levels, the androgen receptors in key organs mentioned above are stimulated and normal organ function returns.

Reluctance of physicians to prescribe testosterone

It used to be taught to medical students that testosterone would be the cause for prostate cancer. This was based on old observations by Dr. Huggins, a Canadian born surgeon who practiced in Chicago, that orchiectomy improved the survival of advanced prostate cancer patients by a small percentage. Dr. Lee pointed out that Dr. Huggins neglected to realize that testicles make both testosterone and small amounts of estrogen.

When an orchiectomy was done (because of the belief that testosterone production was the culprit) inadvertently the real cause of prostate cancer (an estrogen surplus) was also removed thus improving the survival of these patients somewhat. Nowadays we have more sophisticated testing methods. Dr. Abraham Morgentaler (Ref. 1) has compiled a lot of evidence about the importance of testosterone in men. He proved, based on a lot more modern references that it is not testosterone that is the cause of prostate cancer. We know now that estrogen dominance is responsible for prostate cancer and that this develops as stated above because of the low testosterone and low progesterone during the male menopause (also called “andropause”). Dr. Morgentaler, a urologist from Harvard University has taken prostate cancer patients and put them on testosterone. To his and everyone else’s surprise testosterone treated prostate cancer patients improved, their prostate cancer either disappeared or become much less aggressive, which can be measured with the Gleason score based on its microscopic appearance. The result was that they did better, not worse on testosterone.

Unfortunately the history of testosterone, orchiectomy and prostate cancer as explained led to confusion among the medical profession. We now know that testosterone is innocent with respect to prostate cancer, testicular cancer or any other cancer. But some of the old-timers among the physicians doggedly hold on to their false belief from the past because they were taught this way. If a man asks one of these physicians for testosterone replacement he may not only be told that he/she could not do that, but will also receive a tirade of false statements about testosterone.

We dealt with the myth of prostate cancer that is not related to testosterone treatment. There is another myth that older physicians often cite: that testosterone would supposedly be causing blood clots. At the University of Texas Medical Branch at Galveston (Texas, USA) a large study was done involving 30,572 men, ages 40 years and older. They all had venous thromboembolism and received an anticoagulant drug or an intravascular vena cava filter following their diagnosis. They also had a low testosterone level and were given testosterone replacement therapy. They were followed and monitored for further venous thromboembolism. None were found in any of the men. The conclusion of the investigators was that filling a testosterone prescription was not associated with any clotting condition.

Aging and testosterone

The Massachusetts Male Aging Study showed that testosterone has been declining in the male population over a period of 20 years. Partially this was related to aging, but otherwise there may also be environmental factors, called estrogen-like substances or xenoestrogens, that have contributed to it as well. Although age is a factor, there is so much variation from man to man, that it is best to just measure testosterone and determine whether the total testosterone level is above or below 500 ng/dL. This seems to be the most reliable indicator in determining whether a man needs hormone replacement, apart from symptoms due to testosterone loss. These are: increased risks for prostate problems and/or cancer, cardiovascular disease, loss of bone density, a rise in cholesterol and urinary dysfunction. Dr. Randolph describes this in detail and also discusses who needs bioidentical testosterone replacement.

A New England Journal of Medicine study from September 2013 explained that apart from testosterone the male body needs a small amount of estradiol, the female hormone for normal functioning. This is achieved through the enzyme aromatase contained in fatty tissue. But testosterone replacement must be given as the bioidentical testosterone, so that a small amount of it can be converted by aromatase into estradiol. I have reviewed this in a blog entitled “The Full Story About Testosterone”.

Risk of prostate cancer

Having reviewed the hard facts about prostate cancer risk, it is now clear that older men get prostate cancer because of lowered testosterone in their blood and increased body weight, where fat converts androgens by the aromatase into estradiol; this leads to estrogen dominance. Estrogen dominance causes breast cancer and uterine cancer in women and prostate cancer in men. When the total testosterone level in a man is lower than 500 ng/dL it is a sign that he needs testosterone replacement therapy to protect his prostate from prostate cancer.

Cardiovascular disease

As the cardiovascular system has a lot of androgen receptors on its cell surfaces, it is important that the man continues to have the proper stimulus from androgenic hormones (testosterone, dihydrotestosterone and DHEA) for proper contractility of heart cells and relaxation of smooth muscle cells in the arteries to control blood pressure. With a lack of testosterone there is hardening of the arteries, loss of muscle cells in the heart muscle and increase of blood pressure. So far there is only an indication that low testosterone is associated with diabetes, high blood pressure and heart attacks. It has not been proven that it is the cause (so webmd.com says). But careful replacement with bioidentical testosterone helps patients to get rid of their symptoms, have the energy to exercise and feel better. Long-term studies have already shown that hormone replacement saves lives, but the medical profession is slow to accept this (Ref.1). Here is a link that explains this a bit further.

If a man who is low in testosterone wonders whether it would be worthwhile to go on testosterone therapy, here is the clear answer: would you like to have a 47% lowered risk of dying, a reduction of 18% in heart attacks and 30% reduction in the risk for a stroke? This is what a 14-year follow-up study published in the European Heart Journal in August, 2015 found.

The same is true for cardiovascular disease as stated above: if the total testosterone level in a man is lower than 500 ng/dL it is a sign that he needs testosterone replacement therapy to protect his cardiovascular system to prevent heart attacks and strokes.

Loss of bone density

Older men can get osteoporosis, which can lead to compression fractures in the spine and to fractures in the hip, the ankle or wrist. It is thought that with the lack of testosterone there is also a lack of estradiol via the aromatase pathway in fatty tissue. This small amount of estradiol is thought to prevent osteoporosis all his life until the testosterone drops with older age. Once again it is important to monitor his total testosterone level and replace with bioidentical testosterone when it is lower than 500 ng/dL.

Rise in cholesterol

With obesity the metabolic syndrome sets in where the LDL cholesterol is increased. This is a direct risk for hardening of the arteries. In an obese older man with low testosterone there is a double risk from the low testosterone and the metabolic syndrome. As a result the heart attack and stroke rates in obese men with low testosterone are much higher than in obese men with normal testosterone levels. Men with obesity need to lose weight by changing their diet to healthier eating habits and starting a regular exercise program with swimming and walking. At the same time those with a testosterone level of lower than 500 ng/dL should have testosterone replacement with bioidentical testosterone.

Urinary dysfunction

A hyperactive bladder, dribbling, hesitancy and leaking bladder can all be part of testosterone deficiency. But this is not that easy to diagnose. A full consultation by an urologist may be necessary to assess various other causes that could hide behind these symptoms. Part of the work-up though is to measure the total testosterone level and replace with bioidentical testosterone when it is lower than 500 ng/dL

Alzheimer’s disease

Alzheimer’s disease can be due to a lack of testosterone. It is therefore important to measure the total testosterone level in a man. If it is lower than 500 ng/dL, as mentioned before , it is a sign that he needs testosterone replacement therapy to prevent Alzheimer’s disease.

Burnout

According to Dr. Thierry Hertoghe, an endocrinologist from Belgium, there are several hormones that can be missing in a person with burnout: a lack of cortisol, thyroid, growth hormone, testosterone/estrogen, progesterone and oxytocin. The middle-aged manager with burnout would have other hormones missing apart from testosterone. This needs to be measured with blood tests. Whatever is low would have to be replaced with bioidentical hormones.

Some details regarding testosterone measurements and delivery

The deeper you delve into testosterone replacement, the more details there are to consider.

First, there is a sex hormone-binding globulin that is mostly produced by the liver and circulating in the blood.

It is like a storage form of testosterone and only 1 to 2% of the total testosterone is unbound. This is called the free or bioavailable testosterone. Some physicians measure just that portion of testosterone.

Second, when it comes to replacement of testosterone in a man who is deficient for testosterone, there are several delivery systems, which some people find a little confusing. There are testosterone gels, which are least absorbed; another application are creams which are often prepared by compounding pharmacies. These creams are usually well absorbed. But some men do not absorb either creams or gels. They need testosterone injections or testosterone pellets. The goal is to replace testosterone in a manner that there is a fairly equal amount of testosterone available at all times. Some men achieve that only with testosterone pellets, others with testosterone cypionate injections. For this reason blood test that determine the levels of free testosterone are necessary.

Testosterone

Testosterone

Conclusion

Testosterone is a key hormone in the male and needs to be monitored, particularly when he is aging. A careful history of his symptoms needs to be taken by a knowledgeable physician or naturopath. If blood tests show that the total testosterone is less than 500 ng/dL replacement with bioidentical testosterone is needed.

 

References:

Ref.1: Dr. Abraham Morgentaler: “Testosterone for Life – recharge your vitality, sex drive, and overall health” McGraw-Hill, 2009

Sep
05
2015

Health Benefits Of Coconut Oil

Lately coconut oil has enjoyed a renaissance. A few years back it was still considered the saturated fat villain and was accused of causing heart attacks. The problem is that clinical trials could never proof that coconut oil would cause heart attacks or strokes; it actually showed the opposite: coconut oil prevented heart attacks! This is very interesting! This story is related to a powerful lobbying campaign of the soybean oil industry.

But perhaps more interesting is the fact that the medium chain fatty acids of coconut oil have a multitude of applications in the healthcare field so that your wrinkles and hair will benefit, your teeth will get less cavities and gum disease, you will have less infections, the immune system will be stronger and you will get less heart disease. But this is not all: coconut oil has been shown to specifically fight bacterial infections, viral infections, fungal infections and some parasitic infections. Anybody interested in 36 pounds of weight loss over 1 year? With coconut oil it is possible. There are definitely health benefits of coconut oil for you, hence the title of this blog.

In the following I will review this in more detail.

Properties of coconut oil

Coconut oil is derived from the white flesh of the coconut of the coconut palm tree. Cold-pressed coconut oil contains 92% saturated fats, 6%monounsaturated fats and 2% polyunsaturated fats. Olive oil in comparison contains 14% saturated fats, 77% monounsaturated fats and 9% polyunsaturated fats.

Tropical oils are coconut oil and palm kernel oil. These are the best sources of medium and short-chain fatty acids, which are fats ideal for cooking and frying food in a pan as both oils have a high smoking point. Coconut oil contains 64% of medium chain fatty aids (MCFA) while palm kernel oil has 58% of MCFA. Coconut oil is the one dietary oil that is least vulnerable to oxidation and formation of free radicals. This is the reason why it is safest for cooking or deep-frying. It has a melting point of 76 Fahrenheit (25 degrees Celsius). That means it is a white solid fat below that temperature and is a clear liquid oil above this temperature.

Coconut oil is composed of 48% lauric acid, 18% myristic acid, 7% capric acid and 0.5% caprylic acid. The coconut oil is a triglyceride, where three fatty acids are bound to a glycerol molecule. But when it gets in contact with our skin, the skin bacteria immediacy hydrolyze it into free fatty acids and glycerol. The same breakdown is happening in our mouth and gut by our own bacteria. The free fatty acids (FFA) are what give it the beneficial clinical effects. The FFA have antibacterial effects, antiviral effects, antifungal effects and antiparasitic effects. Specifically, lauric acid and monolaurin are the most anti-bacterial compounds of coconut oil. Coconut oil and palm kernel oil are the richest source of lauric acid; they contain almost 50% of lauric acid in their fats. In comparison, butter only contains 3% lauric acid.

Infections treated with coconut oil

Bacteria

Antibiotic resistant bacterial strains have become a serious problem in the past few years. Because of this it is important to know that the fatty acids derived from coconut oil have alternative antibiotic effects. Sinus infection can be treated by consuming coconut oil.

The CDC has reported that 75% of all cases of food poisoning are due to eating ground beef. This is due to resistant E.coli strains from beef that were fed antibiotics, so they would fatten up. The excuse of the Agro industry is that the farmers have to use antibiotics as the cattle in the crowded conditions of feedlots would otherwise get diseases. In 1993 seven hundred people got sick from eating contaminated Jack-in-the-Box hamburgers and at least 4 children died. Other common food poisoning bugs are salmonella strains. In 1994 a milk truck carrying milk that was contaminated with salmonella was shipped to an ice-cream factory in Minnesota. The contaminated ice cream was shipped to stores in several states and led to food poisoning of 224,000 people, the largest food poisoning outbreak in the US history. Giardia is another parasite that is common in India. Here is a study that showed how children with diarrhea due to giardia can be managed with coconut oil.

If you add all the cases of foodborne illnesses each year there are between 6.5 million to 81 million Americans who get sick and about 9,000 die as a result. One of the reasons of death from food poisoning is kidney disease and subsequent kidney failure; another common reason is blood poisoning.

So how does coconut oil fit into foodborne infections? When you eat 1 or two tablespoons of coconut oil three times with meals, the free fatty acids of coconut oil that are released in the gut get taken up into the blood stream and circulate in the body. If the free fatty acids encounter bacteria the medium chain fatty acids infiltrate the membrane of the bacterium and cause it to rupture. The same process happens in the gut to bacteria that do not belong there. Pathological E.coli, salmonella species and other pathological bacteria get eradicated in the same way I have just described. Other bacteria against which coconut oil is effective are H. pylori (the problem bug that causes gastric ulcers), Chlamydia pneumoniae, Haemophilus influenzae, Staphylococcus aureus (rodent study), Pseudomonas aeruginosa, Neisseria (the cause of gonorrhea) and many gram-positive bacteria (Ref.1, p. 75 and 76). I am afraid that most of these claims could not be verified by a PubMed search. PubMed had a reference regarding Salmonella and Pseudomonas aeruginosa in a mouse assay and both of these bacteria did not respond to coconut oil in various concentration.  However, Clostridium difficile, which is a problem bug with chronic diarrhea patients responded to coconut oil treatment.

Some women are plagued by frequent urinary infections. Coconut oil is a simple remedy that will treat these infections and when you eat coconut oil as a supplement or cook with it regularly you are having a good chance to eliminate them altogether.

When men get older they can be plagued by benign prostatic hypertrophy. This is a condition where the prostate is enlarged and squeezes the part of the urethra that travels through the prostate gland. The end result is that he has difficulties urinating. Urologists usually recommend a shaving off the prostatic tissue through a special cystoscopic procedure.

In a study on rats coconut oil was shown to decrease the prostatic weight as a result of treatment with coconut oil. In Ref.1 Dr. Fife stated that 1 to 2 tablespoons of coconut oil three times per day with meals would bring the swelling of the prostate gland down within only a few days and urination would be back to normal. However, I did a PubMed search for human data on benign prostatic hyperplasia and could not find a single literature quotation to confirm this.

Viruses

What about flu bugs? Dr. Fife cited a case of a woman who was just starting to come down with the flu (Ref.1). He recommended that she should take 2 to 3 tablespoons of coconut oil dissolved in lukewarm orange juice with every meal. On the first day her symptoms got worse as one often sees with seasonal infections. On the second day she expected to get worse again, but to her surprise the symptoms were starting to go away. By the end of the third day all of her symptoms had gone!

Other infectious agents that respond to coconut oil are: HIV, herpes-1 and 2, Cytomegalovirus, Epstein-Barr virus (the cause of mononucleosis), influenza virus (all strains), hepatitis C virus, Coxsackie B4 virus and others. A full list can be seen on p. 75 and 76 of Ref.1.

One of the chronic virus infections is hepatitis C. A person who has this condition is at a higher risk of developing liver cirrhosis and subsequently hepatocellular liver cancer. By using Coconut oil in the stage of chronic liver infections with hepatitis C virus the medium chain fatty acids do their trick of invading the outer membrane of the hepatitis C virus. The virus particles all rupture and release their genetic codes and cannot find another way of regenerating themselves. Within a few weeks and months the person can be completely hepatitis C free. Their energy comes back as the liver function returns to normal. From here the patient can rest assured that cirrhosis of the liver and liver cancer won’t develop.

Fungal infections

This is not the end of the surprising effects of coconut oil. Yeast bugs and other fungal infections respond very well to coconut oil. Candida albicans, the cause of gut infections, chronic vaginal infections and opportunistic infections in AIDS patients gets eradicated very similarly to the flu patient described above.

Athletes foot is a fungal infection between the toes that can go on for years with frequent flare ups, but it can be eliminated in just a few days by topical application of coconut oil. If you take it internally as well, it gets secreted through your sweat glands and eradicates the yeast bugs that way.

Parasites

Giardia lamblia is the cause for a common gut infection that is picked up by outdoor enthusiast, when they drink contaminated water. Cryptosporidium is another one of these parasites that won’t make cows sick, but when we consume drinking water that has not been fully sanitized, we get abdominal cramps and diarrhea. AIDS patients get seriously ill from this. Coconut oil comes to the rescue: it will do the same as with all the other bugs: destroy the envelope of the bugs with its MCFA’s, which destroys them. There is no anti-parasitic drug resistance that would develop. Several tapeworms respond very well to coconut oil treatment. However, some parasites like F. hepatica did not respond to coconut oil.

With respect to the transmission of malaria it was found that 2% Neem oil in coconut oil is an effective anti malarial mosquito repellant for 12 hours.

Dr. Fife gave an example of the building of the Panama Canal. The contractors found that the local indigenous Indians were the most reliable workers and never got sick. Yellow fever and malaria were the two diseases that plagued imported workers. According to Dr. Fife investigators found out that the local Indians consumed coconut oil regularly, which kept them slim and infection free including free of malaria and of yellow fever (Ref. 1, p. 94). I am afraid that a PubMed check for pertinent references regarding suppression of malaria and yellow fever could NOT be found.

Dental decay and coconut oil

Due to its broad-spectrum antibiotic properties coconut oil kills the germs that cause dental decay and gum disease, called periodontitis. You will keep the dentist less busy with regular coconut oil intake and save yourself a lot of dental bills.

Less heart attacks with coconut oil

There is a connection between poor dental hygiene, which leads to chronic Chlamydia pneumoniae infection and heart disease. Regular coconut oil consumption reduces heart attack rates and mortality of heart disease. Although the long-chain fatty acids of saturated fat and trans fat (hydrogenated vegetable oils) have been shown to cause hardening of the arteries (arteriosclerosis), this is NOT the case for medium-chain fatty acids from coconut oil. Research has shown that coconut oil is neutral with respect to blood cholesterol. Medium fatty acids are directly metabolized into energy by the liver, so they do not continue to circulate in the blood stream like other fats. In coconut consuming areas like Sri Lanka and Kerala, India very little heart disease was registered until the early 1980’s. Then only one of every 100,000 deaths was attributed to heart disease in Sri Lanka; and only 2.3 out of 1000 people in Kerala, India suffered from coronary artery disease in 1979. In contrast in the US about 333 out of 1000 Americans die of coronary heart disease every ear, that’s 1 in 3 people! Cardiovascular protection is further discussed here.

In this context it is interesting to read on this website that they believe coconut oil would cause heart attacks. Another study in Malaysian volunteers showed the opposite: no sign of changes in cholesterol, triglycerides or inflammatory markers. Many other studies have also shown that the medium chain fatty acids of coconut oil are neutral or beneficial in terms of cardiovascular disease.

Corn oil, safflower oil, grape seed oil, soybean oil, cottonseed oil, canola oil, peanut oil and even olive oil are increasing the risk for blood clots, which in turn is a risk for developing heart attacks and strokes. They are also omega-6 fatty acids that lead to inflammation and indirectly cause heart attacks and strokes. On the other hand, omega-3 fatty acids and the medium chain fatty acids of coconut oil reduce the risk of clot formation. This means there are only three safe oils: omega-3 fatty acids, coconut oil and olive oil when used non-heated and in combination with either omega-3 or with coconut oil. When combined with one or two of the other oils the blood clotting property of olive oil is neutralized.

Several mechanisms investigated in a rat model showed cholesterol-lowering effects of coconut oil. But when it comes to human studies, it was shown in premenopausal Philippine women that lipid profiles were also beneficially influenced by coconut oil consumption.

Improving the looks of your skin and hair

Coconut oil is protecting the skin against damage, heals and gives it a healthy and youthful appearance. It has been observed in Polynesians who are exposed to a lot of sun that they are protected from sunburns by applying coconut oil, and their skin remains youthful looking into an older age without the development of precancerous or cancerous skin conditions. They are eating coconut oil and put it onto their skin as a lotion. Coconut oil helps for extremely dry skin. At the same time it prevents bacterial, viral and fungal infections.

In one study mild to moderate atopic dermatitis skin rashes improved significantly with virgin coconut oil. Many cosmetics contain coconut oil and you may wonder how safe this is. A safety study has been performed regarding coconut oil based cosmetics and you can rest assured that it was found to be very safe.

Even hair can be treated with coconut oil. Dr. Fife quotes a New York hair stylist Amanda George who said: “I massage two teaspoons of warm coconut oil into my hair before bed, then wash it out in the morning.” Her hair is luxuriant, soft and shimmering (Ref. 1, p.135).

Alzheimer’s disease

Coconut oil has an inhibitory effect in terms of the development of Alzheimer’s. It seems that the medium chain fatty acids prevent aggregation of amyloid-β peptide and thus stop the further development in the direction of Alzheimer’s; coconut oil also helps reduce elevated LDL, insulin resistance and hypertension, which are all risk factors for Alzheimer’s disease.

Detoxing with coconut oil

When you first use coconut oil it can have a strong detoxification effect (medically termed “Herxheimer reaction”). It stimulates the immune system and helps the body to get rid of any stored toxins and germs. There can be a skin rash, sinus congestion, nausea, vomiting, fatigue and diarrhea. Not everybody experiences all of these symptoms, but one or the other. This can go on for a day or two, but sometimes it may take longer like several weeks. It may feel as if you are coming down with a flu, but this is not true: you are detoxifying and you will feel more energetic when this is behind you. Coconut oil is hypoallergenic, so it is very rare to have a true allergy to coconut oil. Most people do not experience the above described detoxification reaction.

Lose weight while eating coconut oil

Medium chain fatty acids (MCFA) from coconut oil have a different metabolism than long chain fatty acids (LCFA) like soybean oil, canola oil, safflower oil and others. Studies have shown that MCFA are burnt directly by the liver and lead to a higher body temperature production, called “thermogenic effect”. Various researchers found a two to threefold higher burning of calories in MCFA compared to LCFA. Over one year this translated into a weight loss of 36 pounds, if you replaced all of the LCFA fats in your diet with MCFA fats. Here is a clarification that coconut oil has medium chain fatty acids and is metabolized differently than animal fats. The weight loss happens like a “side effect” when you switch to cooking with coconut oil and supplementing with coconut oil. Here is a weight reduction study that was done in 20 healthy, obese Malay volunteers. They were all males.

Cancer

The role of coconut oil in cancer treatment is not yet investigated. Carbohydrate restriction is one way of starving tumor cells. It is conceivable that a ketogenic diet including coconut oil may be beneficial for cancer patients, but trials to this effect have not yet been done, which means we do not have the evidence for or against it. However, here is a study that showed that breast cancer patients had much less side-effects with chemotherapy when supplemented with coconut oil.

Health Benefits Of Coconut Oil

Health Benefits Of Coconut Oil

Conclusion

Coconut oil has experienced a renaissance in the last view years. It is now available in containers of various sizes as organic virgin coconut oil. Try a small container first and see how you react. In the beginning you may detox and feel like you have the flu for a few days. But later you will have more energy and you’ll gradually notice improvements of energy, of skin and hair. Your body will notice further improvements internally as the immune system functions better and you lose a few pounds. Your heart is pumping blood easier as there is less hardening of the arteries. Cook with coconut oil, as the smoking point for coconut oil is higher than olive oil, which means you are not eating oxidized or toxic oil. Use olive oil in your salad dressings. Throw away all the other oils, such as safflower oil, canola oil, sunflower seed oil, corn oil and soybean oil or grapeseed oil. These are largely omega-6 containing oils that cause heart attacks and strokes as they get oxidized and cause inflammation in the body through the arachidonic acid system.

Remember this: cook with coconut oil and use olive oil for salad dressings.

Read labels and make sure you are not buying the cheaper hydrogenated coconut oil with free radicals in it; opt for the cold pressed, virgin coconut oil, which is more expensive, but healthy.

In reviewing Dr. Fife’s “The Coconut Oil Miracle” I found that there are many experiential stories that may ultimately be true, if confirmed by trials or studies. I have attempted to find references, but could not fond them for all topics mentioned above; be cautious regarding these gaps. I recommend that you keep an open mind, but at the same time stay critical. I think the overall evidence supports that coconut oil is a valuable nutrient that has many positive effects.

 

References

Ref.1: Bruce Fife, C.N., N.D.: “The Coconut Oil Miracle”, 5th edition,2013, Penguin Books, NY 10014

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Aug
22
2015

Tools To Turn 100

A Swedish longevity study that went on for 50 years gave me the idea to blog about the factors that can help you to turn 100 and still have your mental capacity and good health. Let me introduce you to this study.

Researchers at the Sahlgrenska Academy in Göteborg, Sweden (which is the same as the University of Gothenburg) decided back in 1963 to follow a group of 855 Gothenburg men born in 1913 until they would either die or turn 100. The idea was to find out what killer diseases are in the way to reach such a ripe old age and if they would survive, what was it that made them to reach this age.

Think of it as a race to turn 100. The researchers had checkpoints along that journey: various surveys were conducted at the age of 54, 60, 65, 75, 80 and 100 to consider the factors that lead to longevity. 27% (232) of the original group reached the age of 80, and 13% (111) made it to 90. Only 1.1% of the men made it to the age of 100.

What were the causes of death for the other ones who did not make it? 42% of deaths after the age of 80 were due to heart attacks, 20% due to infectious diseases, 8% due to strokes, 8% due to cancer, 6% due to pneumonia and 16% due to other causes. 23% of the men over 80 were diagnosed with Alzheimer’s or dementia.

What else did the researchers find out? Factors that made people survive were refraining from smoking, maintaining a healthy cholesterol level and limiting coffee consumption to not more than 4 cups per day.

Another marker for longevity was either paying high rent for a condominium or own a house; in other words, a certain amount of wealth seems to be associated with longevity. Passing a fitness test at age 53 riding a bicycle was another peculiar finding of the study. This one points to the importance of fitness and clarity of thought as markers for longevity. There was a genetic factor also, as those who had a mother who lived to a ripe old age also survived longer than others who did not have this longevity advantage. However, researchers stressed that overall this genetic factor was of minor importance, the other factors that are under our control were much more important.

Two of the men who were 100 years old dropped out of the study: one because of dementia, the other one for personal reasons. Here are some of the facts about the other seven: none of them smoked; 2 lived at home, 5 in assisted living facilities. All of them wore hearing aids; all of them had good spatial and temporal cognition. All of them were slim, had good posture, but all used walkers to prevent falls or assist them walking. They were all able to read and watch TV, and most of them wore glasses.

Dr. Wilhelmsen who was part of the entire 50-year research effort said about the centenarians: “All of them were clinically healthy, satisfied with their circumstances and pleased to be living where they were.”

Other research about marriage, health and life expectancy

There is some peculiar research that found that men who are married are healthier than single men. This study came from the University College in London and was based on a group of 10,000 British people who were born within one week of each other on March 1958.

Being married or living common-law was beneficial for men compared to single men. One biomarker was the metabolic syndrome (a cluster of obesity, high blood pressure and diabetes), which was found to be 14% higher in non-married males while in females it did not matter whether they were married or not: they had the same low rate of metabolic syndrome. The longer men were married, the healthier they were. This was not so for the single male. Women, who married in their late twenties or early thirties, were much healthier in their later midlife compared to women who never married.

Harvard has published some interesting facts on men and marriage. A survey of 127,545 American adults showed that married men live longer than the unmarried males of the controls. A review of studies in the early 2000 suggested that when men were married to a well educated woman this may be causing heart attacks in the men. Quite peculiar, isn’t it? But this was refuted in a larger 2009 study, which found that married men live longer and are healthier when the partner is well educated.

Unhappiness and stress were singled out as a cause of high blood pressure, which leads to heart attacks later. Harvard reveals several other facts that are important with respect to longevity: cancer mortality is higher in unmarried men than in married ones; married men are at a lower risk of developing depression. They were found to have higher rates of satisfaction with life in retirement than their peers who never married. Marriage protects cognitive function and leads to a reduced risk of Alzheimer’s disease. Marriage is also associated with improved blood sugar levels and better outcomes with respect to cancer treatment or when hospitalized for other reasons.

General factors leading to longevity

We heard now several interesting points that seem to be linked to longevity. But what is it exactly that is behind some of these observations?

1. Diet

The Mediterranean diet is the gold standard as it has been shown to lead to the lowest mortality rates among diets.Note that longevity increases even more when sugar and starchy foods are avoided. And yes, a Mediterranean diet cuts down the risk for Alzheimer’s disease.

2. Exercise

It has been shown in many studies that regular exercise will reduce all diseases by about 50%! This is better than any medication; this is simply a must, if you are at all interested in living longer and healthier. Not only will your heart benefit from that, but your mind will thank you and not enter into dementia.          

3. Alcohol

This has been drummed to death, but the limit is 1 glass of red wine for women and 2 glasses of wine for men. Personally I do not believe that this is true. I have explained in a blog that the same heart protective effect can be achieved by 250 mg of resveratrol as supplement and avoiding alcohol altogether will prevent a number of cancers.

4. Smoking

Originally the Framingham Heart Study has shown that smoking is an important risk factor for heart attacks and strokes. Hundreds of other studies have verified this. Despite this fact women as a group are now repeating the experiment that has already been completed for men: smoking causes lung cancer and many other cancers as well as cardiovascular disease. I see young women thoughtlessly walking around town puffing their lives away.It shows you how powerful cigarette commercials are. Sometimes it is frustrating to watch this as a health care provider!

5. Stress management

This means seeking ways to reduce stress like meditation, self-hypnosis, yoga and others. This also means building social ties and mutually supportive relationships. It makes you feel that you belong, you have your place in society, you help others, and they support you.

6. Avoiding iatrogenic disease

Physician-caused illness is getting more common. Medications have become stronger and often have more potent side effects. For instance, if a physician treats a gluten-induced rash called dermatitis herpetiformis with a drug called Dapsone, the patient can get severe anemia, violent abdominal cramps and bloody diarrhea. A strict gluten-free diet would probably have helped the patient to clear up the rash. All of the symptoms that the patient had to suffer as a result of Dapsone were from this “iatrogenic disease”, which simply means they happened as a result of the doctor’s malpractice that had caused a medication-induced disease.

7. Avoiding exposure to free radicals

Many different agents like substances from pollution, radiation, rancid unsaturated oils and others contain free radicals that damage tissues and cause inflammation. Antioxidants like vitamin C, E and resveratrol can stop this as is reviewed here.

8. Using vitamins and supplements

As already indicated this will help to reduce free radical exposure by the use of antioxidants; reduce inflammation by using omega-3 fatty acids, Co-Q-10, vitamin C and E, resveratrol and others.

9. Avoid accidents

As you are aware, accidents can kill. Wear seat belts, drive safely, and stick to speed limits, particularly in curves. Also don’t drink and drive, don’t use your phone and don’t text and drive. The use of street drugs is also a common cause for accidents.

10. Use bioidentical hormone replacement

When we experience the change of life, called menopause in women and andropause in men we can allow nature to knock us off the planet or use scientific knowledge. It has been proven that it is perfectly safe not to use Big Pharma’s hormone concoctions that the body cannot recognize. Synthetic hormones cause iatrogenic disease as proven in the Women’s Health Initiative. Bioidentical hormones, however simply replace what is missing in menopause and andropause.

The reason this is important is that our system has hormone receptors on the surface of all body cells. In order to have normal function, we depend on bioidentical hormones to assist cell metabolism. For instance the heart muscle in a man has testosterone receptors as has his brain. In women estrogen receptors and progesterone receptors are contained in the cells. Using the right mix of bioidentical hormones based on saliva hormone tests or blood hormone tests can help the treating physician or naturopath to rebalance the body’s natural hormone needs with bioidentical hormone creams applied to the skin.

Tools To Turn 100

Tools To Turn 100

Conclusion

Tools to turn a hundred years old and still be fairly alert and fit are listed above. It is important that we start thinking along those lines, because it is only prevention that gets us safely there. If you allow yourself to constantly live it up and run your health down, how can you expect to turn 100? In the last 50 years the life expectancy has risen at least 20 years (85 years now, 65 years then). Now we are seeing a downward trend in the obesity and overweight population and the diabetics. They are the ones vulnerable to iatrogenic disease and mortality. They also are at a higher risk to die from heart attacks and strokes and they are more likely to get Alzheimer’s disease. Also, single men would do well to see their physician more often to check out their health status and perhaps change detrimental lifestyles that married men would not get into, because their wives talk to them. If you can switch from a curative approach in healthcare that usually does not work too well anyways to a preventative approach, you have a good chance to make it to 100. I talk to you then.

Jul
31
2015

Two Is Better Than One: Omega-3 And Krill Oil

Omega-3 fatty acids have gotten a lot of limelight in the press; krill oil was kept more in the background by the media. But both omega-3 and krill oil are important for your health.

What can confuse you is the following paragraph that I picked up from Facebook:

“I cannot believe that in the last 7 days 3 Doctors have asked me what krill omega-3 is. One would think that those who look after our health would realize that the high levels of mercury in the regular omega-3 has reached dangerous levels. Krill oil is harvested from pristine waters of the Antarctic Ocean and tested to be free from harmful levels of mercury. If you have not heard of it, it is for brain, heart, joint and immune health.”

Clarification of what Omega-3 fatty acids are

Depending on where fish is within the ocean’s pecking order of feeding, the levels of mercury of the fish oil that contains omega-3 fatty acids will be higher or lower. Tuna, for instance is one of the predator fish on top of the line. They are large predator fish, and as a result, not a fish you want to eat as it has very high levels of mercury. Salmon on the other hand is lower in the line of predator fish. That’s why it is still recommended to eat salmon two or three times per week. Fish oil is pooled from various fish and then molecularly filtered through a special filter that removes heavy metals like mercury, cadmium and others. Knowing these facts, the Facebook text above may be accurate in stating, “regular omega 3 has reached dangerous levels”, but it is inaccurate for the molecularly filtered omega-3 fish oil, which is the only one I would recommend as a supplement. Having said that there are still significant differences in quality according to a report online that tested 51 common products in the US. The omega-3 fatty acids EPA and DHA are stored in the membranes of platelets and in circulating plasma triglycerides, which is useful for the functioning of the lining of our arteries. This is called endothelium and needs to be healthy to lower blood pressure and prevent hardening of the arteries. Omega-3-fatty acids support the cardiovascular system foremost and the brain secondarily.

Where does Krill oil come from?

Krill oil comes from tiny crustaceans called krill that provides additional benefits that are not found in fish oil alone. Although the initial concentration of raw krill oil has less mercury per milliliter than omega-3 fatty acid fish oil, it still needs to be molecularly filtered to remove heavy metals. Also bear in mind, that the tiny crustaceans live in the same polluted ocean waters as other fish. It is a sad fact that our oceans are no longer pristine! The same is true for the Antarctic Ocean. After the filtering process both krill oil and omega-3 fatty acid fish oil are equal in their quality (free of mercury, other heavy metals, PCB and dioxins).

The omega-3 fatty acids of krill oil have an affinity to bind with phospholipids in red blood cells. This enables krill oil to cross the blood-brain barrier and get into the brain cells providing support for the brain. In this respect krill oil has an edge over omega-3 fatty acids to support the brain. But secondarily it is also good for your heart and the lining of the arteries.

Benefits of marine oils like krill and fish oil

It is best to think about krill oil and omega-3 fatty acids (fish oil) as complementary marine oils that have multiple beneficial effects on the body.

Studies have shown that arthritis and osteoarthritis are helped by krill oil, but also by fish oil. Similarly, heart attacks and strokes are prevented with both krill oil and omega-3 fatty acids. It appears that both oils reduce inflammation in the arteries that are associated with high blood pressure, diabetes, obesity and the metabolic syndrome in obese people. C-reactive protein measuring inflammation was reduced by krill oil up to 30% compared to placebo within 30 days. Patients with arthritis had 20% and more reduction in stiffness and pain.

Krill oil is well absorbed into the brain and can prevent age-related brain shrinkage, preserve cognitive function and memory, prevent dementia and also possibly depression.

Other health conditions improve on both krill oil and omega-3 fatty acids like osteoporosis (in combination with vitamin K2, vitamin D3 and calcium), a weak immune system, diabetes, high triglyceride levels and cholesterol problems. Both marine oils prevent LDL cholesterol from being oxidized, which helps to prevent atheroma formation and hardening of the arteries. This prevents heart attacks and strokes.

Fear mongering Facebook write-ups

In this context let me clarify the fear mongering Facebook write-up cited at the beginning of this blog. It is a misconception to think that krill oil is devoid of mercury. It is only so, if it was molecularly filtered, which removes all of the mercury and more, but it leaves the beneficial DHA and EPA (omega-3 fatty acids) intact. In the same vein omega-3 fatty acids from fish oil are initially more mercury containing, but after molecular filtration are entirely mercury free, the same as krill oil after molecular filtration. But the mix of omega-3 fatty acids is slightly different with krill oil being a bit richer in DHA and attaching to red blood cells easier while fish oil omega-3’s attach to triglycerides in the liquid phase of the blood, called plasma and also to platelet membranes. So neither krill oil or omega-3 fatty acids are better than the other; they are slightly different and that’s why you benefit from a mix of both. It would be a big mistake to follow the Facebook advice above and only take krill oil by blindly trusting the quotation. In my opinion it is simply a marketing plot to get you switched from fish oil to krill oil.

What combination of Krill oil and omega-3 fatty acid should I take?

Most trials with krill oil have been done with 300 mg of krill oil per day.  I take a dosage of one capsule per day of 300 mg. There are several manufacturers that produce similar products. I also take 3 capsules of omega-3 fatty acids twice per day. Each capsule has 647 mg of EPA and 253 mg of DHA, which translates into a daily dose of 3882 mg of EPA and 1518 mg of DHA. Again, there are several products from which you can choose. The reason I take a relatively high dose of fish oil is the fact that I come from a family background with severe arthritis that started in several relatives at an age of 50+. I have no sign of arthritis at age 70. It may be the result of taking these supplements and staying away from sugar and starchy foods. I need my joints to do ballroom and Latin dancing and I also need them to attend the gym regularly. Exercise by itself has been shown to prevent arthritis and prevent heart attacks and strokes. We need the benefit from all these things in combination: good nutrition, supplements and exercise.

Two Is Better Than One: Omega-3 And Krill Oil

Two Is Better Than One: Omega-3 And Krill Oil

Conclusion

Both krill oil and fish oil (omega-3 fatty acids) are needed as supplements to prevent arthritis, strokes, heart attacks, osteoporosis, diabetes, dementia, Alzheimer’s and inflammation. The key to a good krill oil or fish oil supplement is to buy the more expensive products that are molecularly distilled and therefore more concentrated, but also free of heavy metals and other contaminants. These supplements are only a small part of your overall anti-aging program that needs to include good nutrition (organic food), exercise, other supplements and if necessary bioidentical hormone replacement.

Reference: Dr. R. Schilling: “A Survivor’s Guide to Successful Aging“. Paperback through Amazon.com, 2014. This text explains the anti-aging program I follow and includes recipes composed by my wife for 1 week.

Jul
18
2015

MIND Diet Helps Prevent Alzheimer’s

Researchers at the Rush University developed the MIND diet that helps prevent Alzheimer’s disease. MIND stands for “Mediterranean-DASH Intervention for Neurodegenerative Delay” and is a hybrid between the Mediterranean diet and the DASH diet that had been developed to help control high blood pressure.

The MIND diet was a prospective study where 923 people aged 58 to 98 years participated. Researchers followed these people for 4.5 years. Three groups of diets were tested: Mediterranean diet, DASH diet and MIND diet.

The MIND diet study result

The adherence to the diet was measured: those who stuck to the diet very closely, another section of participants that were less diligent, and finally one segment of people who did not take the entire thing too serious. With regard to the MIND diet the group with the highest adherence to the diet reduced the rate of Alzheimer’s by 53% compared to the lowest third. The second group still was able to reduce the rate of Alzheimer’s by 35%. The control diets were the DASH diet and the Mediterranean diet. The group that were strictly adhering to the DASH diet reduced Alzheimer’s by 39%, the group that were very conscientious in adhering to the Mediterranean diet reduced Alzheimer’s by 54%. The middle thirds of both control diets did not show any difference versus the lower thirds. The conclusion was that a strict Mediterranean diet has a very good Alzheimer prevention effect, as does a strict MIND diet. However, when patients do not adhere too well to a diet, the MIND diet is superior still yielding 35% of Alzheimer’s prevention after 4.5 years while the other diets when not adhered to that well showed no difference from being on a regular North American diet.

A brief summary of what Alzheimer’s disease is

A few years back the Pittsburgh PET scan was invented. It uses a Pittsburgh B compound radio-tracer to visualize the pathology in the Alzheimer’s brain. This research tool has made it possible to detect even the earliest Alzheimer’s disease (AD). The basic problem in Alzheimer’s patients is that there is brain atrophy, which can be more located in the front of the brain or in the back. There are two types of AD, the early onset AD (EOAD) and the late onset AD (LOAD). Using the Pittsburgh PET scan it was noted that the brain atrophy with EOAD is severe and located in the back of the brain; in contrast to that with LOAD, which is the more common form of AD the brain atrophy is located in the front of the brain. This imaging tool also allows quantitating the amyloid load; amyloid is a gooey substance that is produced by the inflammatory changes in the brain of Alzheimer’s patients (Ref.1). There are multiple possible causes why Alzheimer’s should develop in a person, but nothing conclusive has been determined. In February, 2015 I summarized a talk given by Dr. Smith at the 22nd Annual A4M Las Vegas Conference that also mentioned that there are many causes that can lead to Alzheimer’s disease.

The bottom line is that atrophy of the brain leads to loss of memory, personality loss and premature death.

The MIND diet

This diet was developed by Martha Clare Morris, Ph.D., a nutritional epidemiologist of Rush University in Chicago and her colleagues. The team observed that some foods were associated with a delay in the onset of Alzheimer’s disease while others contributed to an earlier onset of Alzheimer’s.

This is how they developed the term of the 10 “brain-healthy food groups” and the 5 unhealthy food groups.

Meet the 10 “brain-healthy food groups”: green leafy vegetables, other vegetables, berries, beans, nuts, poultry, olive oil, whole grains, fish and wine.

The 5 unhealthy food groups are: red meats, cheese, pastries and sweets, butter and stick margarine, fried or fast foods.

The 10 brain-healthy food groups are full of anti-oxidants, resveratrol and healthy fatty acids. They prevent hardening of the arteries and prevent the deposits of beta amyloid in the brain, which prevents Alzheimer’s disease. There is a bit of an issue about wine, which I have reviewed in this blog. You can replace wine with resveratrol extract as a supplement in order to get away from the toxic effect of alcohol, which is a cell poison. The choice is yours.

Why are the unhealthy foods unhealthy? There is too much trans fat in butter, cheese and margarine, which accelerate hardening of your arteries. The same problem exists with red meats, pastries and fried or fast foods. Sweets pose another problem: the sugar causes insulin levels in your blood to raise, which in turn causes inflammation in the support tissue of your brain, called glia cells, which secrete the beta amyloid that damages brain cells. At the same time sugar is metabolized by the liver into fat and triglycerides, which causes hardening of the arteries. The end result is earlier onset of Alzheimer’s.

According to Morris blueberries and strawberries, which are part of the brain-healthy food groups have been shown to be the most potent berries in terms of protecting against Alzheimer’s disease and preserving cognitive function.

With the late onset AD (=LOAD) that is the most common form of AD genetic factors hardly play a role. But what we eat will determine whether or not we get AD and we can postpone it significantly, if we eat mostly foods from the 10 brain-healthy food groups.

MIND Diet Helps Prevent Alzheimer’s

MIND Diet Helps Prevent Alzheimer’s

Conclusion

The MIND diet has been shown to be able to postpone the development of Alzheimer’s disease. It was developed based on the observation that some foods are good for us in terms of preserving cognitive function whereas others are bad. Knowing this it is advisable to eat mostly vegetables, poultry, fish, olive oil, nuts, beans, berries, whole grains, and some wine may be enjoyed as well. At the same time you need to avoid the bad foods mentioned above, like pastries, sweets, red meat, cheese and fast foods.

It is a small price to pay to keep your brain function until a ripe old age. The advantage with the MIND diet is that if you should occasionally deviate from the ideal, you still maintain a significant advantage over the DASH diet or the simple Mediterranean diet.

Reference:

1. Goldman’s Cecil Medicine, Twenty-Fourth Edition, Goldman, Lee, MD; chapter by David S. Knopman: Alzheimer’s Disease and Other Dementias, p. 2274-2283 Saunders 2012.