• New Alzheimer's Genes

    New Alzheimer’s Genes

    A recent genetic study summarized in a CNN article describes the detection of new Alzheimer's genes. First of all, it appears that Alzheimer's genes and trigger factors have to interact to cause Alzheimer's disease. Secondly, in a 2013 study the International Genomics of Alzheimer’s Project had examined a population … [Read More...]

  • Healthier After Age 60

    Healthier After Age 60

    Unhealthy lifestyles have staying power, so what can we do be healthier after age 60? A recent CNN article describes 10 ways how to adopt a healthier lifestyle when you get close to retirement. The thinking is that 5 years before your retirement at 65 you should perhaps adopt a healthier lifestyle. 2017 study by … [Read More...]

  • Obesity Fuels Cancer Development

    Obesity Fuels Cancer Development

    A recent review by the American Cancer Society found that obesity fuels cancer development. As a matter of fact, what the researchers found was that younger millennials are more in danger of both getting obese and of getting obesity related cancers. Also, the rates of baby boomers with respect to obesity-related … [Read More...]

  • Immune System Can Trigger chronic fatigue syndrome

    Immune System Can Trigger chronic fatigue syndrome

    A study from February 2019 stated that the immune system can trigger chronic fatigue syndrome. Specifically, researchers observed that interferon treatment in hepatitis C patients could lead to chronic fatigue syndrome in 33% of patients. Interferon treated hepatitis C patients can develop chronic fatigue … [Read More...]

  • Live The Life That We Evolved For

    Live The Life That We Evolved For

    A review article at CNN by a psychiatrist recommends that we live the life that we evolved for. Dr. Arash Javanbakht, an assistant professor of psychiatry at Wayne State University in Detroit, MI explains that man lived on this planet only since 200,000 years. But it takes about 1 million years for evolutionary … [Read More...]

  • Exercise For Different Age Groups

    Exercise For Different Age Groups

    In a health article CNN reported about exercise for different age groups. Exercise has profound positive effects on the body. First it strengthens the lungs and the heart. Secondly, it conditions your muscles. Thirdly, exercise can protect you from chronic diseases like heart disease, type 2 diabetes and many … [Read More...]

    Apr
    13
    2019

    New Alzheimer’s Genes

    A recent genetic study summarized in a CNN article describes the detection of new Alzheimer’s genes. First of all, it appears that Alzheimer’s genes and trigger factors have to interact to cause Alzheimer’s disease. Secondly, in a 2013 study the International Genomics of Alzheimer’s Project had examined a population of 75,000 Alzheimer’s patients. Thirdly, in a new Feb. 28, 2019 publication of the same research group the population of Alzheimer’s disease patients had been enlarged to 94,437. This gives the study a higher statistical power. Previously the group had identified 20 genetic risk loci for late-onset Alzheimer’s disease (LOAD). In the 2019 study 5 new genetic loci for Alzheimer’s disease were identified. Specifically, one of them is the neurological and immune-mediated disease haplotype HLA-DR15. It is a risk factor for LOAD.

    Reconfirmation of some older Alzheimer’s research findings

    Notably, this latter finding shows that immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism are all sharing a connection in the development of late Alzheimer’s disease. In the past they have been implicated in the development of familiar Alzheimer’s disease. Now it became apparent that changes in the immune system, changes in the lipid metabolism and the onset of Alzheimer’s disease have an association also in late-onset Alzheimer’s disease. Research from 2016 showed that in obese patients the metabolic syndrome can indeed trigger the genotype CYP46 to develop Alzheimer’s disease.

    It seems that a variety of factors, like the CYP46 genotype and the metabolic syndrome with elevated cholesterol levels are interacting to cause amyloid beta plaques. In addition, neurofibrillary tangles from tau protein deposits are also part of the pathology of Alzheimer’s disease. These appear to lead to damage of nerve cells.

    Prevention of Alzheimer’s disease

    Inasmuch as it has become clear how many factors have to come together to trigger the development of Alzheimer’s disease, it is important to point out the factors that counter the development of Alzheimer’s.

    Several genetic loci have to work together to cause Alzheimer’s

    Research has defined many genetic loci tcyphat have impact on the development of Alzheimer’s disease. Researchers have stated that in order to develop Alzheimer’s disease several of these genes and risk factors that trigger the genes into action must occur in combination. This is in contrast to Parkinson’s disease or Huntington’s disease where only one genetic mutation causes the disease.

    Resveratrol

    Certainly, this powerful antioxidant from the skin of red grapes has a positive effect on early Alzheimer’s patients with improvement of their memory.

    Correction of hormone deficiencies

    With older age many of our hormones are decreasing or vanishing. But replacement of the missing hormones with bioidentical hormones has shown to prevent the onset of Alzheimer’s disease. This link explains that replacement of low testosterone in males and estrogen replacement in females is important to prevent Alzheimer’s. In addition, in women progesterone also has a neuroprotective function. Melatonin in both sexes is a powerful anti-oxidant hormone that preserves brain tissue. Thyroid hormone, if low, also needs replacement to maintain memory.

    Other lifestyle factors affecting the onset of Alzheimer’s disease

    Sugar and too much starchy food

    Heavy consumption of starchy foods like potatoes, rice, bread and pasta as well as sugar are risk major factors. They contribute to the early onset of Alzheimer’s disease. Sugar consumption (and starch, which gets metabolized within 30 minutes into sugar) causes oxidization of LDL cholesterol and plaque formation of all the blood vessels including the ones going to the brain. On the long-term this causes memory loss due to a lack of nutrients and oxygen flowing into the brain.

    Lack of exercise

    Lack of exercise is an independent risk factor for the development of Alzheimer’s disease. Exercise increases the blood supply to the brain, strengthens neural connections and leads to growth of neurons, the basic building blocks of the brain. Exercise also increases mood-regulating neurotransmitters like serotonin and endorphins.

    Vitamin D intake

    A 2014 study showed that a low vitamin D level had a strong association with a high risk of dementia and Alzheimer’s disease. Specifically, the findings were as follows.

    • Vitamin D level of less than 10 ng/ml: 122% increased risk of Alzheimer’s
    • Vitamin D level 10 to 20 ng/ml: 51% increased risk of Alzheimer’s

    The same research group found in two trials that vitamin D deficiency leads to visual memory decline, but not to verbal memory decline.

    Generally supplements of vitamin D3 of 5000 IU to 8000 IU are the norm now. But some patients are poor absorbers and they may require more- up to 15,000 IU per day. The physician can easily determine what the patient needs in the dosage of vitamin D3 by doing repeat vitamin D blood levels (as 25-hydroxy vitamin D levels). The goal is to reach a level of 50-80 ng/ml. The optimal level with regard to nmol/L is 80 to 200, according to Rocky Mountain Analytical, Calgary, AB, Canada.

    Sleep deprivation

    Sleep deprivation leads to memory loss, but so does the use of aspartame, the artificial sweetener of diet sodas. Make your own homemade lemonade. Squeeze the juice of half a lemon. Add mineral water to fill an 8 oz. glass. Add a tiny bit of stevia extract for sweetening. Stir and enjoy. Stevia has been in use for thousands of years and is non-toxic contrary to other artificial sweeteners.

    Avoid insulin overproduction

    I already mentioned the effect of sugar consumption above. But here I am mentioning it again because of the insulin reaction to sugar. An overload of refined carbs leads to an overstimulation of the pancreas pouring out insulin. Too much insulin (hyperinsulinemia) causes hormonal disbalance and leads to diabetes type 3, the more modern name for Alzheimer’s. All starch is broken down by amylase into sugar, which means that anybody who consumes starchy food gets a sugar rush as well. Too much sugar in the blood oxidizes LDL cholesterol, which leads to inflammation in the body. The consequence of chronic inflammation is as follows: hardening of the arteries, strokes, heart attacks, Alzheimer’s and brain atrophy, arthritis, Parkinson’s disease and cancer. It is because of this that a Mediterranean diet or a MIND diet is a sensible pollution for Alzheimer’s patients. Both of these diets have been shown to be anti-inflammatory.

    New Alzheimer's Genes

    New Alzheimer’s Genes

    Conclusion

    At the present time research knows of a total of 25 genetic risk genes for Alzheimer’s disease. It appears that they have to interact, and lifestyle factors can be a trigger to cause Alzheimer’s disease. This means that we can interfere with the development of Alzheimer’s disease. Get into some form of regular exercise like swimming, walking or Yoga exercises. Refrain from eating sweets and starchy foods. Adopt a Mediterranean diet or a MIND diet. Replace any missing hormones with bioidentical ones to re-establish your hormone balance. Watch your vitamin D3 intake. We need a lot more of it than what was previously known t to prevent the onset of this disease. Ensure you get enough sleep. This helps your brain to regenerate overnight. A resveratrol supplement every day will improve your memory, as a study has shown.

    These are some of the easy steps you can do to avoid getting Alzheimer’s disease.

    Apr
    06
    2019

    Healthier After Age 60

    Unhealthy lifestyles have staying power, so what can we do be healthier after age 60? A recent CNN article describes 10 ways how to adopt a healthier lifestyle when you get close to retirement.

    The thinking is that 5 years before your retirement at 65 you should perhaps adopt a healthier lifestyle.

    2017 study by Dr. King regarding lifestyles before and after retirement

    Dr. Dana King was the author of a 2017 study where lifestyles before and after retirement were compared.

    Seven factors were examined, namely cardiovascular factors including physical activity, healthy diet, healthy weight, smoking status, total cholesterol, glucose, and blood pressure. Retirees were more likely to have poorly controlled blood pressures compared to non-retirees. 23.9% of retirees had uncontrolled blood pressure versus 15.1% of non-retirees. This difference was statistically significant. There was another significant difference with regard to physical activity. Retirees were 1.85-fold more active than non-retirees. But sadly, the other 5 of the 7 points did not significantly improve. There were no differences in healthy weight, smoking rates, healthy diet, glucose levels or cholesterol control.

    Healthier after age 60: how to change your diet

    Adopt a Mediterranean diet. This is an anti-inflammatory diet that prevents hardening of the arteries. It lowers the bad LDL cholesterol and also triglycerides. It is also recommended to consume at least 2 tablespoons of olive oil per day. When you cook only with olive oil and use only olive oil and Balsamic vinegar for salads, it is relatively easy to reach or surpass the recommended 2 daily tablespoons of olive oil.

    Healthier after age 60: how to change your exercise status

    You have more time when you retire. The easiest to get into a routine regarding regular exercise is to get a membership in a gym. In the beginning you may want to see a trainer to show you some routine exercises on weight machines. You start the program off with 30 minutes on the treadmill. Before long you get used to the exercise routine and you feel stronger. But your system also produces much more of the protective HDL cholesterol, which is sensitive to regular exercise. If you have been physically inactive, get some input from your health care provider.

    Healthier after age 60: how to change your weight

    It is not exercise, but a healthy diet, which controls your weight. Having adopted a Mediterranean diet is a big first step in that direction. But it is also important to cut out sugar and starchy foods (potatoes, rice, bread, muffins, pasta etc.). This will reduce your LDL cholesterol and triglycerides. On the long term you prevent heart attacks and strokes.

    Healthier after age 60: how to change your smoking status

    It is old knowledge that smoking cuts down on life expectancy. Better quit smoking now than later. It prevents heart attacks, strokes, lung cancer and many other cancers.

    Healthier after age 60: how to lower your blood pressure

    Regular exercise, weight loss and quitting to smoke will all lower your blood pressure. Some people though continue to have high blood pressure. It is important to seek medical advice regarding this. People with persistent elevated blood pressure need medication to have this controlled in order to avoid getting a hemorrhagic stroke.

    Healthier after age 60: how to lower your glucose levels

    The diet I described will help you to control your blood sugars. Your doctor can order a hemoglobin A1C, which summarizes your average blood sugars over the past 3 months. Controlling your blood sugar is important to prevent type 2 diabetes. Diabetes reduces your life expectancy significantly. The risks are heart attacks, strokes, blindness, leg amputations, kidney damage and cancers.

    Healthier after age 60: how to lower your cholesterol

    When I discussed a healthy diet, I indicted that it lowers the LDL cholesterol and triglycerides. This reduces the risk of hardening of the arteries. A regular exercise program increases the protective HDL cholesterol, which reinforces the protection from heart attacks and strokes.

    Healthier After Age 60

    Healthier After Age 60

    Conclusion

    Whether we retire or not, we should all strife to achieve these 7 changes of lifestyle that Dr. Dana King has discussed. They were cardiovascular factors including physical activity, healthy diet, healthy weight, smoking status, total cholesterol, glucose, and blood pressure. Each of these factors is important on its own. But when you tackle all of them simultaneously, there is a potentiation of these factors that allows you to get super-healthy. That’s what you want for your life after age 60. It is not too late to start! You want to be healthier after age 60!

    Mar
    30
    2019

    Obesity Fuels Cancer Development

    A recent review by the American Cancer Society found that obesity fuels cancer development. As a matter of fact, what the researchers found was that younger millennials are more in danger of both getting obese and of getting obesity related cancers. Also, the rates of baby boomers with respect to obesity-related cancer were much lower than rates from millennials.

    Results of the study showing obesity fuels cancer development

    In like manner, as the summary by CNN shows, there is an increase of obesity and also an increase of various cancers of the population of millennials versus the same age group among baby boomers. As an illustration, take pancreatic cancer, one of the obesity related cancers. Normally it occurs in people above the age of 65. Here is the increase of frequencies according to age group:

    Ages 25 to 29: 4.34% increase.

    People aged 30 to 34: 2.47% increase.

    Age bracket 35 to 39: 1.31% increase.

    Those aged 40 to 44 years: 0.72% increase.

    With this in mind you can see clearly that the younger age group is at a higher risk for developing pancreatic cancer. Certainly, the problem is that obesity in children has become more rampant and this has led to early obesity by the age of 35. The other side of the coin in this case is an increased pancreatic cancer rate.

    Other cancers that are obesity-related

    Indeed, 6 out of 12 obesity related cancers have shown an increase in frequency because of increasing obesity. These cancers are: multiple myeloma, colorectal cancer, uterine cancer, gallbladder, kidney, and pancreatic cancer.

    Notably, people born around 1985 had a higher rate of multiple myeloma and kidney cancer than people born around 1950. Multiple myeloma was 1.59-fold higher and kidney cancer 4.91-fold higher in the group of people born around 1985 in comparison to people born around 1950.

    Cancer associated with obesity, but may not be caused by obesity

    MD Anderson Cancer Center’s Dr. George Chang, who was not associated with the analysis cautioned: “The study was not set up to establish causation. We know there are many factors that have an association with both obesity and cancer, such as lack of exercise and poor diet. How much each of those factors contribute to cancer is less clear.” Specifically, the study found that the rate of obesity-related cancers in millennials now is about double the rate of what it was in baby-boomers at the same age.

    Discussion of the obesity and cancer problem

    1. First of all, obesity is now starting in childhood, teenagers and young adults. 5 of the 6 obesity related cancers (colorectal, uterine, gallbladder, kidney and pancreatic cancer) have increased in the younger population. These require mostly surgery and according to Dr. Chang, who is an oncological surgeon, complication rates are higher among obese patients. Dr. Chang added that chances are also that complications will be more severe.
    2. Secondly, we need government-sponsored programs to reverse the obesity trend. This should include changing the diet from the Standard American diet (essentially junk food) to a Mediterranean diet. There should be an elimination of sugar and starchy foods or the use should be just a bare minimum. Reducing or even eliminating red meat is definitely necessary. The WHO has determined that beef, pork and lamb are causing cancer, because they contain weak carcinogens.  Coupled with this is the necessity to initiated regular exercise programs.
    3. Thirdly, fatty tissue in obese patients release growth factors and proteins that function as hormone-like factors stimulating cell growth. These factors stimulate any carcinogenic process. Researchers are still actively working on analyzing this process further.
    Obesity Fuels Cancer Development

    Obesity Fuels Cancer Development

    Conclusion

    Childhood obesity has already had the result that obesity-related cancers (multiple myeloma, colorectal cancer, uterine cancer, gallbladder, kidney, and pancreatic cancer) occur at a younger age and more frequently. The cancer rate among obese millennials now is already double the number of what the baby-boomers was at the same age. The key is to treat obesity aggressively with regular fitness programs and with a major diet shift. We know what caused the obesity wave. It is overconsumption of sugar, junk foods, starchy foods, processed foods and fat overuse.

    A major change in diet

    This means the kids need to cut out sugar. An alternative is to sweeten only with stevia, if they need a sweet taste. They also need to cut out starchy foods like potatoes, pasta, rice, bread and processed food. Processed food contains a lot of sugar and gluten from wheat. Gluten and sugar both stimulate the appetite center. This is what we want to avoid. What remains is a Mediterranean diet without the junk from the North American diet. You end up eating a lot of vegetables, salads and fruit. Fish is a good protein source, poultry as well. Implementing these changes will show positive results for the health of the entire population, not only the millennials.

    Mar
    23
    2019

    Immune System Can Trigger chronic fatigue syndrome

    A study from February 2019 stated that the immune system can trigger chronic fatigue syndrome. Specifically, researchers observed that interferon treatment in hepatitis C patients could lead to chronic fatigue syndrome in 33% of patients.

    Interferon treated hepatitis C patients can develop chronic fatigue syndrome

    In this cased 54 patients with hepatitis C received treatment with Interferon. 18 of them (33%) developed chronic fatigue syndrome, which persisted. 57 control did not develop it. With this in mind, patients were examined at baseline, during the 6 months to 1-year Interferon treatment and 6 months following the end of the treatment.

    It was noted that baseline interleukin levels (IL-6 and IL-10) were higher in the fatigued patients. Interferon treatment worsened the interleukin levels, and the interleukin levels stayed high from then on. Moreover, symptoms of pain from chronic fatigue syndrome also stayed with the patients after the treatment had ended.

    Patients with chronic fatigue syndrome have a viral illness in the beginning

    The lead researcher, Carmine Pariante, professor of biological psychiatry at King’s College London, noted the following. Before patients come down with chronic fatigue syndrome they frequently have a major infection or a flu virus. This certainly mobilizes an interferon response from their immune system. Professor Pariante said that it is the overstimulation of the immune system that leads to an overproduction of interferon, which likely causes chronic fatigue syndrome.

    In the US an estimated 836,000 to 2.5 million Americans present with chronic fatigue syndrome according to the CDC.

    The observation described above confirms the theory that a chronic stimulation of the immune system likely underlies the development of chronic fatigue syndrome. It was the patients undergoing treatment for hepatitis C with interferon, persistently high IL-6 and IL-10 levels together with pain symptoms that caused chronic fatigue syndrome.

    Example of a patient with chronic fatigue syndrome

    A 19-year old patient with chronic fatigue syndrome (CFS) explained that her CFS kept her hostage inside. When she gets dressed it feels like there is a blackness going over her eyes. She cannot lead a conversation or speak as she has absolutely no energy. So, the only thing she can do is to lie down and exist. Her pain and fatigue is  debilitating. She feels that her body and brain are unable to recover from even the smallest effort. About 25% of CFS cases are severe cases. This means that they are house bound, bedridden and wheelchair dependent.

    Immune System Can Trigger chronic fatigue syndrome

    Immune System Can Trigger chronic fatigue syndrome

    Conclusion

    The cause of chronic fatigue syndrome (CFS) has been a mystery for a long time. But a new UK research study has shed some light on a hyperactive immune system that may cause CFS. The research team found that 33% of patients with hepatitis C who received treatment with interferon developed CFS. When lab tests analyzed their blood values, they had developed high interleukin levels (IL-6 and IL-10). This was a sign for an overstimulation of the immune system. Other patients who did not develop CFS normalized their interleukin levels. The control patients had no changes in interleukins.

    Overactive immune system can trigger chronic fatigue syndrome

    The researchers are of the opinion that an overactive immune system is responsible for the development of CFS. Chronic fatigue syndrome is a devastating multi-system chronic disease with pain and weakness. A significant number of patients suffer from permanent disability. The researchers hope that with more research they may be able to find a solution and treatment protocol. Presently no form of treatment is available.

    Mar
    09
    2019

    Live The Life That We Evolved For

    A review article at CNN by a psychiatrist recommends that we live the life that we evolved for. Dr. Arash Javanbakht, an assistant professor of psychiatry at Wayne State University in Detroit, MI explains that man lived on this planet only since 200,000 years. But it takes about 1 million years for evolutionary changes to take place. As a result of this we tend to still behave in our lives the way we may have reacted 10,000 years ago. It is useful to think back of us being hunters and gatherers.

    Anxiety, an ancient emotion

    Anxiety, for instance, is an emotion that goes far back to 10,000 years ago when humans had to be part of the tribe. If an opposite tribe was fighting them chances were high that they could get killed. Even if your own tribe did no longer like you, there was a strong possibility that you were driven out or killed. This left us with an inheritance going back many millennia of anxiety. In modern life though it is the boss who does not like something you did. It could be a deadline for a school or college project that makes us anxious or some political news. The reasons have changed, but anxiety is still there!

    Live the life that we evolved for: assess what we eat

    Food was very scarce 10,000 years ago. When the tribe finally caught some prey, there was a feast where fatty food, meat, vegetables, fruit, nuts and seeds were eaten. Refined sugars were not available. You did not know when the next time would come where you had ample food. Today we still behave this way: we eat what we can and eat some more. The only problem is that there is no longer the pattern of famine orfeast. Instead there is easy access to the fridge with all kinds of food. We also have access to fast food places. And we drink sodas, eat candies and other sweets. Eventually we end up fat and fatigued.

    Live the life that we evolved for: which way do we move?

    Our ancestors had to run and walk many miles a day to find food. They may have been attacked by wild animals and had to flee. They also needed to chase a prey for food. Constant movement was the order of the day. What are we doing today? We did not evolve to step into a car and drive to work. We also did not evolve to sit at a desk from 9AM to 5PM. In the evening we sit in front of the TV or lie on a couch eating munchies and drinking beer.

    Our modern life

    It is no wonder that we gain weight, that our heart and lungs do not get conditioned, and that our muscles are a pile of mush. We need to think back what our bodies were built to do. Perhaps a long walk would be healthier than sitting all the time. Some of us do not mind to visit a gym daily and build an exercise routine into the day. This mimics the activities of the hunter/gatherers and is a lot better for our bodies.

    Live the life that we evolved for: sleep problems

    Many people today have problems to fall asleep. The sun had 100% control of the diurnal rhythm in the past. Now we have artificial lightning, blue light from TV’s, computer screens and iPhones. We are constantly getting stimulated. In addition, the stories we read or see on TV get us excited, so that the stress hormone, cortisol is released and melatonin, the sleeping hormone gets suppressed. Taken all this together, it is not really a wonder we have problems sleeping. Relaxation methods can help us to tone down before we go to sleep. You may want to meditate, do self-hypnosis, practice some yoga or just lie still and relax, clearing your mind, and more importantly switch the TV off and put the computer on “sleep”. Sleep for you comes easier this way.

    Live the life that we evolved for: our fears

    10,000 years ago fear was a normal part of our lives. There were predators you had to fear. There were tribal wars where you had to fight for your survival. You had to fear starvation. The fight/flight response was a reality. Compare this to our lives now. We may fear an exam, a meeting at work or agonize what to wear for a party. We have no real existential fears unless you live in a war zone. Many people may feel that they do not have enough fear in their lives, so they get drawn to horror and mystery stories, computer games, haunted houses etc. But this is fodder for anxiety!

    Live the life that we evolved for: how to feel better

    When we adopt a pet, let’s say a dog, we understand that it needs food, exercise, love and sleep. But when it comes to the human animal in us, we find it hard to understand that we need that too. In fact, we need to live the life that we evolved for. We need some form of exercise all the time, because that is what we were meant to do 10,000 years ago and our bodies are still built for that. When you walk the dog, you may make new friends or even a date. If you go to the gym, you realize that your muscles work better and begin to make your body fitter. You will also feel better about yourself. You appreciate that your mood is lifting, and you feel the increased energy and strength.

    Dr. Arash Javanbakht said about the bottom line:

    “If we treated our body the way responsible dog owners treated their dog, we would live a much happier life.”

    Live The Life That We Evolved For

    Live The Life That We Evolved For

    Conclusion

    It takes people 1 million years for evolutionary changes. We do not change our behavior fast. Dr. Arash Javanbakht, an assistant professor of psychiatry at Wayne State University in Detroit, MI compared our lives now with the lives of the hunters/gatherers in the past. People ate fatty food, meat, vegetables, fruit, nuts and seeds when a prey was hunted. But then there was an episode of fasting. People then had to walk and run all day long to catch some food again or they had to run to escape from a predator. Nowadays we use cars for transportation, use the elevator to get upstairs and walk from the table at home to the TV set. If we do not move enough and we eat the wrong foods, we do not turn fit but we turn fat.

    Our modern lives

    We also use LED lights from TV’s, computers, iPhones and tablets that interfere with our diurnal hormone rhythm. It is not about going back to sending smoke signals, but it is all about setting limits and when to stop and disengage from social media and the phone. Not setting limits is part of why we have problems to sleep. Stress can also be a factor of insomnia. Dr. Javanbakht says that we need to relearn how our bodies were built. We need proper nutrition without high-energy carbs. In addition we need regular exercise that will help us to relax and feel more energy. Anxieties will lift and we will feel better about ourselves.

    Mar
    02
    2019

    Exercise For Different Age Groups

    In a health article CNN reported about exercise for different age groups.

    Exercise has profound positive effects on the body. First it strengthens the lungs and the heart. Secondly, it conditions your muscles. Thirdly, exercise can protect you from chronic diseases like heart disease, type 2 diabetes and many cancers. Each age group needs different exercises, as follows.

    Growing up years

    During childhood exercise helps to grow healthy bones, regulate weight and build up self-confidence. In addition the child sleeps better, when exercise is part of the course of the day. Children should try out various sports. They should learn how to swim and how to handle a ball. They should also play in playgrounds together with other kids. Several studies have shown that during the teen years exercise levels decline steadily, particularly for girls. Especially during the teen years regular exercise builds a healthy body image and helps adolescents to manage stress and anxiety. Parents should encourage teens to keep one team sport regularly. For those who are not into team sports, swimming and any kind of sport is a good substitute.

    Exercise for different age groups: in your twenties

    In your mid twenties you are at the highest performance level in your life. You have the fastest reaction time and your heart pump capacity is the highest. Exercise physiologists measure this by an expression, called VO2 max. This value decreases each year by 1%. Your reaction time also decreases every year. The good news is that you can slow down the decline by exercising regularly for the rest of your life. If you train your body regularly during this time, your lean body mass will be preserved and your bone density will stay dense until your later years. To make it more interesting, vary your training with various sports.

    If you are a regular exerciser, talk to a trainer about interval training, which intermittently pushes your exercise limit to the maximum. This type of training releases human growth hormone from your pituitary gland. The effect of this is that you increase your stamina and endurance. It also builds up lean muscle mass, decreases body fat content and provides you with more energy.

    Exercise for different age groups: in your thirties

    Family life and stress at the job can be a reason that you forget about exercise. But right now there is a particular need to maintain a regular exercise program. You may want to get up early, work out at a gym and go to work from there.

    Some employers encourage those who work at a desk to get up every 30 minutes and have a brief exercise break for only 2 or 3 minutes. There are computer programs that show you what to do and all you have to do is copy what you see on the screen. Keep good posture while you sit. When you need a rest room break, you may decide to use the rest room downstairs. This gets you to climb some stairs and use the muscles that were resting when sitting at the desk.

    As already outlined for those in the twenties, high-intensity interval training is a tool where you can exercise for only 20 minutes intensely. You do a burst of maximum exercise that brings you up to 80% of your maximum heart rate. This can be done cycling or sprinting and is alternated with low intensity exercise.

    Women should do Kegel exercises (pelvic contractions) following labor to prevent incontinence.

    Change exercises around to keep them interesting.

    Exercise for different age groups: in your forties

    This is the time when a lot of people put on extra weight. Resistance training is a way to counteract this by burning fat and preventing the loss of 3-8% of muscle mass per decade. As this link shows, 10 weeks of resistance training increases muscle mass by 3 pounds (1.4kg), increases the resting metabolic rate by 7% and decreases fat by 4 pounds (1.8kg). Exercise machines in gyms or Pilates equipment in Pilates centers will give you this type of training.

    Exercise for different age groups: in your fifties

    Many people develop joint aches when they are fifty and older. Also, chronic diseases like heart disease, type 2 diabetes and others are starting to get more frequent. In postmenopausal women, where estrogen is on the decline, heart disease is getting more common. Bioidentical hormone replacement can reverse these problems. Strength training twice a week will counter muscle loss that you would get otherwise without any regular exercises. Do weight-bearing exercises like a fast walk where you breathe a bit faster and where you break out into a sweat. This will make your bones and muscles stronger and prevent osteoporosis. Tai Chi, yoga and Pilates are all exercises suitable for this age group.

    Exercise for different age groups: in your sixties

    This age group is characterized by the fact that multimorbidity is getting more prevalent. People often have mental and physical illnesses. Or they have diabetes and heart disease. They often are on multiple drugs for various conditions. Aging is also a strong risk factor for developing many cancers. But regular exercise can prevent many cancers. For instance post-menopausal breast cancer, colon cancer and cancer of the womb are cancers that can be prevented to a certain extent with regular exercise. Heart disease and type 2 diabetes will also largely improve with regular exercise.

    Physical exercise tends to decline in this age group for various reasons. Some reasons are obesity, various diseases that make individuals more sessile and general disability. It is important to resist this trend as much as possible. Take ballroom dance lessons and join the dancing community. Any other dance type (Latin, Bachata, Salsa, Kizomba, Argentine dancing etc.) is good exercise and enjoyable as well. It is a fun way to socialize and exercise at the same time. Aqua-aerobics is a great way to keep your joints and muscles in good shape. People with arthritis will tolerate this. Use brisk walking to maintain your cardiovascular fitness. Do strength and flexibility exercises twice per week to maintain your muscle mass and your balance.

    Exercise for different age groups: in your seventies and beyond

    Frailty and falls are common in the 70’s and 80’s. Many fractures are happening needlessly. Keep exercising regularly and your muscles will be strong enough to prevent falls. Walk and talk with friends instead of sitting around a table. It is good for your friends to walk as well. If you have several chronic conditions, talk to a physiotherapist or exercise professional what type of exercises you should do. You need some strength, balance and cardiovascular exercises. Enlist the help of a trainer. Sustained exercise is what benefits you most. Think of brisk walks, swimming and aqua-exercises.

    Exercise For Different Age Groups

    Exercise For Different Age Groups

    Conclusion

    We are born to stay active. Movement is life. As long as we live, we need to do regular exercise. This way a lot of chronic diseases will be prevented and even many cancers as well. I have summarized that for different age groups there are different activities that are appropriate. But the key in all age groups is to move and keep your lean muscle mass from shrinking. As explained, this will automatically make you also lose a few pounds. Strength exercises (also called resistance exercises) are the key to achieving this. When you get older, you are not exempt from exercising. Now even more than before your well being depends on exercising regularly. You want to prevent osteoporosis, falls and fractures. You want to avoid chronic diseases, heart disease and diabetes, and exercise is one valuable key to achieve this.

    Feb
    23
    2019

    Combatting Hair Loss

    Dr. Alan Bauman gave a talk about combatting hair loss. This talk was part of the 26th Anti-Aging Conference of the American Academy of Anti-Aging Medicine in Las Vegas from December 13 to15, 2018.

    Dr. Bauman is the owner of many hair loss clinics around the US. Dr. Bauman said that the baldness gene is present in 4 out of 7 men. The gene codes for male alopecia, which means hair loss. We are all familiar with it. First it causes only a receding hairline in the front. Later it causes thin hair and baldness at the crown. But in later years this gene causes baldness in males. One of the metabolites of testosterone, DHT (dihydrotestosterone) causes hair follicles to miniaturize. The result is that hair is no longer covering the scalp skin as much as it used to.

    Mild hair loss

    In the case of mild hair loss local application of 5% Minoxidil will often make a big difference. The physician will want to order a testosterone blood level. It this is low, replacement with testosterone will restore his libido, normalize his erectile dysfunction and give him more energy. Often his hair growth will also recover to a certain extent. Together with Minoxidil 5% he may be doing well for 5 or 10 years.

    But eventually the persistence of DHT as the end metabolic product of testosterone gets the upper hand and causes more hair loss.

    Low-level laser therapy is another method how to re-stimulate the atrophied hair follicles to grow to full hair again. Dr. Bauman showed amazing before and after images that documented vigorous new hair growth with low-level laser therapy.

    Moderate hair loss

    Those men who have the baldness gene will experience more severe hair loss by the age of 30 to 40. More effective methods are necessary to help him. Oral finasteride is one medication the doctor can prescribe. But one of the side effects can be a decrease in libido, which many men will not like. But the patient can apply finasteride 0.25% topical to the hair. This reduces systemic side effects, but helps the hair to grow. Minoxidil 5% can be combined with topical finasteride.

    Platelet rich plasma

    One step further is the use of platelet rich plasma. Blood is collected from the patient. A dual-spin procedure produces platelet rich plasma. This was tested in the laboratory and showed about 7-fold the amount of lymphocytes, 3-times the amount of monocytes and 6.3-fold more platelets than whole blood. This PRP preparation is injected into the areas where hair growth is missing. If there are still atrophied hair follicles present in the scalp, lush new hair growth will develop following PRP injections. The effect of the PRP injections can also increase by additional low-level laser therapy. PRP is especially useful for the treatment of alopecia areata, which otherwise would be difficult to treat. To a certain degree PRP injections will also serve a male well that has androgenic hair loss.

    Severe hair loss

    When a male with the baldness gene enters the late 50’s or 60’s there may no longer be viable atrophied hair follicles present in the bald areas. This is when you have to make a decision whether to shave your whole head and embrace baldness or whether you are using the more expensive hair transplant method. The occipital hair, even in bald people is not responding to DHT. This is why occipital hair is the ideal donator site for a hair transplant. This consists of harvesting DHT-resistant hair follicles from the occipital scalp and transplanting them into the areas that are in need to be cosmetically improved. It is a time consuming procedure, transplanting one follicle at a time.

    Hair transplant

    The technique is either manual transplantation or robotic-assisted hair transplant surgery. As only parts of the occipital hair follicles are useful material, there is no scar or baldness from the surgery. In 7 days the occipital area has healed over. A man may require 3 or 4 hair transplants in a lifetime to cover up areas of the scalp that were balding because of the baldness gene. But the end result is natural looking hair that now is resistant to DHT as it was transplanted from the occipital scalp. A total of four hair transplants are possible without denuding the scalp region. Dr. Bauman showed many before and after photos of men who had hair transplants.

    Combatting Hair Loss

    Combatting Hair Loss

    Conclusion

    Hair loss is common, perhaps more so in men than in women. However, in both cases a lot of therapeutic approaches are possible. Milder hair loss responds to treatment with Minoxidil 5%. In addition finasteride in a local 0.25% topical application is a choice. When hair loss is more severe, PRP (platelet rich plasma) injections into the scalp area are a possibility, but only where viable, but atrophied hair follicles are not growing enough hair. This may give a very acceptable result.

    But the aging male who has genetic baldness working against him needs to consider a hair transplant with DHT resistant hair follicles from the occipital scalp into the bald areas.

    The beauty is that there is a solution for every one. Due to extensive research of the various methods you can trust that they will give you the results you want.

    Feb
    16
    2019

    The Most Addictive Drugs

    Recently CNN reported about the most the 5 most addictive drugs. Before I review these drugs I like to briefly describe the dopamine reward system in the brain.

    Introduction

    The pleasure center consists of the nucleus accumbens, the amygdala and the hippocampus. Together they contain dopamine neurons that communicate with the grey matter nerve cells in the prefrontal cortex. A pleasurable meal, sex, winning a video game, listening to music, earning money and reading a funny cartoon can all cause dopamine release that is perceived as pleasure. But so can drugs, such as smoking cigarettes, drinking alcohol and taking street drugs. The problem is that these latter dopamine releasing substances and drugs cause stronger activation of the dopamine system than natural rewards. But unlike natural rewards they do not cause satiety. This is the basis why drug addiction can kill.

    Review of the five most addicting drugs

    The neuropsychopharmacologist David Nutt has been part of a committee that decided what the five most addictive drugs are.

    Heroin

    This is the most addictive drug. It is an opiate that causes the dopaminergic neurons to release up to 200% more dopamine than usual in experimental animals. Heroin is dangerous, because the dose that kills a person is only five times higher than the dose that leads to a high. Most deaths occur because of overdoses.

    Cocaine

    This drug turns dopamine neurons on, but prevents them from turning the dopamine signal off. In animal experiments cocaine caused the dopamine level to get elevated three times the normal level. 21% of people will become dependent on cocaine sometime during their life when they try it. Methamphetamine, another street drug, is similar to the strength and addictive qualities of cocaine.

    Nicotine

    When a person smokes a cigarette, the nicotine in it reaches the brain quickly as it is absorbed through the lungs and transported in the blood vessels to the brain. In 2002 there were about 1 billion people on earth who smoked. Every year about 8 million people die from smoking. It was shown in rats that smoking causes dopamine levels in the reward system to rise 25% to 40%.

    Barbiturates

    This class of drugs also has the name “downers”, because they calm you down and put you to sleep. But they also killed Elvis Presley and Michael Jackson. Both died from an overdose, which suppressed their respiratory center, and they stopped breathing. In low doses barbiturates stimulate the brain and they cause euphoria, but higher doses cause respiratory failure. Nowadays barbiturates are more difficult to get, because physicians prescribe different drugs for insomnia. When a drug is not easily obtainable, it tends to fade in importance in the addiction scene.

    Alcohol

    In contrast to barbiturates alcohol is readily available. When a person consumes alcohol, the dopamine neurons release between 40% and 360% more dopamine than usual. 22% of people who consume alcohol develop a dependency problem later in life. The WHO estimated that about 2 billion people are addicted to alcohol and 13 million are dying from it every year. The causes of death are varied: car accidents, cirrhosis of the liver, alcohol induced dementia and various cancers.

    Dr. Amen’s brain scans

    Dr. Amen is a psychiatrist who specializes in SPECT scan technology. SPECT stands for Single Photon Emission Computerized Tomography. This is summarized in this review.

    Briefly, a SPECT scan shows where the blood flows in the brain and where it doesn’t flow. People who abuse drugs or nicotine develop areas that have a lack of perfusion. It looks like holes in the brain as depicted in this link, which can create abnormal thinking patterns. Fortunately with drug rehabilitation the brain pattern can normalize again.

    The Most Addictive Drugs

    The Most Addictive Drugs

    Conclusion

    The hallmark of drug and nicotine addiction is that the addicted person relies on using a drug to release dopamine from the reward system. Normal pleasures that would do this such as good food, sex or exercise are no longer acceptable to the addicted person. They need drugs, alcohol or nicotine to experience a stronger response. Dr. Amen’s work has shown that this behavior leads to altered brain function with holes visible on SPECT scans (Single Photon Emission Computerized Tomography). Rehabilitation from drug use normalizes the findings on SPECT scans and helps the patient to return to normal functioning.

    Feb
    09
    2019

    New Thought Model On Cancer Cure

    Israeli scientists believe they found a new thought model on cancer cure. The heading in the Israeli Post boldly declares ”A cure for cancer? Israeli scientists say they think they found one”. The subheading is even bolder: ”We believe we will offer in a year’s time a complete cure for cancer.”

    When you read on, you learn that the company has done some basic research on cancer treatments. The name of the company is “Accelerated Evolution Biotechnologies Ltd.” and the foundation of the company goes back to 2000. In 2019 the heading promises that they have found the cancer cure. But in the text it says they hope that within one year they will find the cure. All these statements don’t quite add up and this dampens your hope for a cancer cure somewhat.

    Previous attempts that failed providing the cancer cure

    Dr. Ilan Morad, the CEO of the company said that traditional cancer chemotherapy has its limits, because it attempts to inhibit a target on the cancer cell surface or inside the cancer cell. But the cancer cell fights back and the cancer becomes resistant to the treatment.

    New approach

    Dr. Ilan Morad and his colleague, Dr. Hanan Itzhaki wanted to approach this problem differently. Essentially, the researchers stated that it is better to attack multiple targets on the cancer cell, which they call MuTaTo approach (multi-target toxin). Morad stated: “The probability of having multiple mutations that would modify all targeted receptors simultaneously decreases dramatically with the number of targets used,” Morad continued. “Instead of attacking receptors one at a time, we attack receptors three at a time – not even cancer can mutate three receptors at the same time.” The cancer cell attempts to activate detoxification steps to inactivate the toxin. But when the toxin is powerful enough, it will eliminate the cancer cells.

    MuTaTo technology similar to triple therapy in AIDS

    Morad explained that the MuTaTo technology would be similar to the triple therapy in AIDS. For AIDS patients this has been the break through. The patient takes a protease inhibitor in combination with two other drugs called reverse transcriptase inhibitors. In the past patients took these drugs one by one, but each became resistant to the treatment. Now the drugs overwhelm the infected AIDS cells, but the normal cells do not get damaged. The MuTaTo technology works similarly against cancer cells. With this technology there is a connection between 12 amino acids in sequence and the main molecule. This is akin an octopus attacking a cancer cell. The peptides are not long enough for the immune cells to attack them, but powerful enough to be toxic to cancer cells.

    Phage technology for cancer attack

    Most mutations of cancer cells come from mutated cancer stem cells. This means that the anti-cancer peptides of the MuTaTo technology will also kill the cancer stem cells. This technology employs phages, which are viruses that attack bacteria. However, the researchers modified the phages with anti-cancer peptide attachments. The research team completed mouse experiments where they transplanted human tumors into mice. The modified phages eradicated the tumors without attacking the normal cells of the mice. Next they want to do clinical trials on humans, which according to Dan Aridor “could be completed in a few years”. Dan Aridor said:
    “Our cancer cure will be effective from day one, will last a duration of a few weeks and will have no or minimal side-effects at a much lower cost than most other treatments on the market,” Aridor said. “Our solution will be both generic and personal.” Aridor added: “Our results are consistent and repeatable.”

    Future likely development

    Cancer treatments take time to be tested and to be refined. Typically there are 4 phases in clinical trials.

    There is a small trial on humans to test the toxicity of a new anti-cancer drug (Phase 1 trial)

    Then there is a larger trial on humans where the questions are: which cancer types are responding to the treatment modality, what is the proper dosage, what are side effects and how to deal with them? (Phase 2 trial)

    Another trial compares the new treatment with the standard treatment up to this time (Phase 3 trial)

    Researcher do the the last clinical trial when the treatment has a licence. More about effects and side effects are investigated. What are the long-term risks and benefits? This is called Phase 4 trial. It is clear from the above that there is still a long pathway from the initial description of the MuTaTo technology to the final product that works in cancer patients. We are at least 5 to 10 years away from a possible success. If there are toxicity problems, the technology would have to be reexamined in the lab, then again reviewed in clinical trials.

    New Thought Model On Cancer Cure

    New Thought Model On Cancer Cure

    Conclusion

    Israeli scientists have detected a new potential cancer therapy. It involves bacteriophage technology and a multi target toxin approach in fighting cancer. In essence small peptides are aiming at various cancer cell targets at the same time. Researchers have been testing the technology on mice. Next laborious multiphase clinical trials will have to begin, before it can be declared a safe anti-cancer therapy.

    First published here: https://www.quora.com/What-are-opinions-of-Israels-announcement-to-have-discovered-the-cure-for-cancer/answer/Ray-Schilling

    Feb
    02
    2019

    Hormones Helping In Menopause

    Dr. Filomena Trindade presented a talk about hormones helping in menopause. This talk was part the 26th Anti-Aging Conference of the American Academy of Anti-Aging Medicine in Las Vegas from December 13 to 15, 2018. The exact title of her talk was “Women and cognition: insulin, menopause and Alzheimer’s”. Above the age of 80 Alzheimer’s disease in women becomes much more common compared to men. PET scans of the brain of postmenopausal women in comparison to PET scans of premenopausal women, often show more than 30% slow down of metabolism after menopause. Literature regarding that finding showed that it was mostly the decline in ovarian estrogen production that was responsible for the slow down in brain metabolism. Other factors that lead to Alzheimer’s disease are central adiposity (abdominal) and inflammation in the body.

    Brain insulin resistance and Alzheimer’s

    Older women with Alzheimer’s have more IGF-1 resistance and IGF-1 dysfunction. Other studies showed that minimal cognitive impairment (MCI) progressing into Alzheimer’s disease (AD) might be due to type-2 diabetes. One of the studies stated the following:

    “We conclude that the term type 3 diabetes accurately reflects the fact that AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 DM and type 2 DM.“

    Another publication said that type 3 DM is a neuroendocrine disorder that represents the progression of type 2 DM to Alzheimer’s disease.

    Dr. Trindade presented several hormone studies in postmenopausal women who started to develop Alzheimer’s disease. Older women with existing Alzheimer’s did not respond to estrogen hormone replacement. They did not recover with regard to their memory loss. However, younger women who just entered menopause responded well to estrogen hormone replacement and many recovered from their memory loss.

    Hormone changes in menopause

    There are a number of hormones that experience changes with the onset of menopause. Estrogen production ceases in the ovaries. The production of progesterone in the ovaries also ends. In addition thyroid and adrenal gland hormone production decreases. Often insulin production is increased, but insulin resistance is present at the same time.

    Stress can interfere with progesterone and aldosterone production as pregnenolone is the same precursor molecule for both hormones.

    How stress interferes with Selye’s general adaptation syndrome

    Stage 1 of Selye’s adaptation syndrome, called arousal, involves elevation of cortisol and DHEA. When stress is over, the patient recovers on his/her own.

    Stage 2 is the adaptation stage, where cortisol is chronically elevated, but DHEA is declining. The patient feels stressed, has anxiety attacks and may experience mood swings and depressions.

    Stage 3 is the exhaustion stage. The underlying cause of this stage is adrenal insufficiency. Both cortisol and DHEA blood levels are low. Patients often suffer from depression and chronic fatigue.

    Other hormones and menopause

    DHEA and cortisol (stress) have the same precursor (pregnenolone). This means that when a patient is stressed, DHEA production tends to suffer as most of the pregnenolone is used for the production of cortisol.

    Dr. Trindade spent some time explaining the complicated details of thyroid hormones during menopause. In essence stress can interfere with the normal metabolism of thyroid hormones with respect to T3, T4 and reverse T3. The end result is that not enough functioning thyroid hormones are present and hypothyroidism may develop.

    Both estrogen and progesterone are lower in menopause. In a longitudinal French study with over 80,000 postmenopausal patients the women that received replacement with bioidentical progesterone and estrogen did the best in terms of low Alzheimer’s rates and lower heart attack rates. You achieve optimal Alzheimer’s prevention best starting hormone replacement at the time when menopause starts. You need both estrogen to control hot flashes and to give you strong bones, and progesterone for preservation of your brain, your hair growth and a good complexion.

    Hormones Helping In Menopause

    Hormones Helping In Menopause

    Conclusion

    Hormones are missing in menopause and this becomes the starting point for many postmenopausal complaints of patients. The sooner the physician does blood tests to diagnose hormone deficiencies, the better. Various studies showed that the best result in terms of Alzheimer’s prevention is possible, when estrogen and bioidentical progesterone are replaced right at the beginning of menopause. This approach prevents neuroinflammation. There are no extracellular beta amyloid protein deposits and no intracellular tau protein deposits that typically are present with Alzheimer’s disease. In addition the cardiovascular system stays healthier for longer. It contributes to preventing heart attacks and strokes. A longitudinal French study with over 80,000 women who have received treatment with a combination of estrogen and bioidentical progesterone have excellent survival data. The women also enjoy excellent mental health, no cardiovascular complications and less cancer than controls without hormone treatment.