• Anxiety Is Common

    Anxiety Is Common

    Recently a review article was published that showed that anxiety is common. This research was conducted in England (Cambridge and London). 48 reviews about anxiety around the globe were examined. The results showed that anxiety in the world population fluctuates between 3.8–25%. Women (frequencies … [Read More...]

  • Mediterranean With Healthy Fat

    Mediterranean With Healthy Fat

    If you want to lose weight, have you considered eating Mediterranean with healthy fat? A lot has changed in recent years regarding recommendations for healthy food intake. In the eighties and nineties the low fat diet was recommended, which unfortunately was high in carbs and led to obesity. What we … [Read More...]

  • Avoid That Heart Attack

    Avoid That Heart Attack

    Recently Dr. Mark Hyman mentioned a 7-point program to avoid that heart attack. If you follow the recommendations below, chances are that you do not only avoid heart attacks, but also strokes, high blood pressure, diabetes and obesity. The Potsdam (or EPIC) study has shown that adhering to 4 … [Read More...]

  • Zika Virus

    Zika Virus

    Recently the question was asked on the news whether it was safe to go to the Olympics in Brazil; so here is some background information about the Zika virus. Zika virus was first isolated from mosquitoes in a forest named Zika forest in Uganda, which was in 1947. Zika virus belongs into the virus … [Read More...]

  • Prevent Unhealthy Aging

    Prevent Unhealthy Aging

    We know that stress can age you prematurely, but what do we need to do to prevent unhealthy aging? This is exactly what this review by cardiologist Dr. Joel Kahn has done. It points out that the right lifestyle makes the difference. Studies showing how to prevent unhealthy aging Several studies … [Read More...]

Jul
22
2016

Anxiety Is Common

Recently a review article was published that showed that anxiety is common. This research was conducted in England (Cambridge and London). 48 reviews about anxiety around the globe were examined. The results showed that anxiety in the world population fluctuates between 3.8–25%. Women (frequencies of 5.2–8.7%) and young adults (frequency 2.5–9.1%) are suffering from anxiety more. Among people with chronic diseases there is considerable variation in the frequency of associated anxiety (from 1.4% to 70%). The frequency of anxiety in various ethnic populations varies considerably around the world. For instance European and North American cultures have a relatively high anxiety rate in the population (3.8–10.4%) when compared to Indian and Asian cultures with only 2.8%. In Africa the rate is 4.4%, in Central and Eastern European countries the rate is 3.2%. In North Africa and the Middle East the anxiety rate is 4.9% while in Spanish/Latin cultures the rate is 6.2%.

Anxiety is common; subtypes

There are many subtypes of anxiety that have been researched. 

  1. Generalized anxiety disorder (GAD): This disorder affects 6.8 million adults, or 3.1% of the U.S. population. Women get this condition twice as often than men. The risk for developing it is greatest between childhood and midlife. People with a mild case of GAD can cope and work. Severe cases can be disabling and may be difficult to treat.
  2. Social anxiety disorder: about 15 million US citizens suffer from this. This equally affects women and men. Typically it starts at the age of 13, but 36% of people will not ask for medical help for 10 years or more. Symptoms of anxiety surrounding social situations are so intense that it interferes severely with making friends and having romantic relationships. They end up being alone, powerless against their anxiety.
  3. Panic disorder: 6 million US citizens or 2.7% of the population suffer from this. Women commonly are twice as often affected by it than men. Panic attacks develop in early adulthood. They often suffer in silence; distance themselves from friends, family and caregivers who could offer them help. Panic disorders often occur simultaneously with depression and medical conditions like asthma, irritable bowel syndrome and substance abuse.
  4. Specific phobias: 19 million or 8.7% of the US population suffer from this. It often starts in childhood and the median onset is at age 7. People affected by specific phobias may be afraid of high bridges, of animals like spiders or mice, of thunder, of flying and a myriad of other things. It disrupts daily routines, causes limitations of work efficiency and reduces self-esteem. It also places a strain on relationships because people afflicted by this problem will do whatever they can to avoid the uncomfortable or terrifying feelings of phobic anxiety.
  5. Obsessive-compulsive disorder: 2 million or 1% of the population in the US suffer from this form of anxiety. Onset is in the teenage years, although 1/3 of adults with obsessive-compulsive disorder experienced symptoms already in childhood.
  6. Posttraumatic stress disorder (PTSD): 7 million people or 3.5% of the US population are suffering from PTSD. Women are much more affected by PTSD than men. But a lot of soldiers who were involved in direct combat situations will suffer from PTSD. Rape can be a source of PTSD. Most people who experience traumatic events and develop PTSD will be affected by it for months or even years, but eventually recover from them; a minority will not recover. Often therapy is helpful for these individuals.
  7. Major depressive disorder: 8 million American adults or about 6.7% of the U.S population will suffer from depression between the ages 15 and 44 years. It is more common among women. A certain percentage of depressed people commit suicide. Anxiety is often mixed in with depression.
  8. Persistent depressive disorder is a form of depression that persists for at least 2 years. 1.5% of the US population or 3.3 million adults suffer from this condition. The median onset is at age 31. Like with depression, so also with persistent depressive disorder, anxiety is very common.

Anxiety is common; related illnesses

There are many medical diagnoses where anxiety is often part of the symptom complex. The medical profession often talks about psychosomatic diseases. This means that these diseases have an anxiety overlay, which is part of the condition.

  • For instance, bipolar disorder is a condition where extreme mood swings are common, often between elation and mania, but then switching to deep depression with suicidal thoughts. Mixed into this condition is often a certain degree of anxiety, which can be very overwhelming.
  • Irritable bowel syndrome is a psychosomatic disease of the gut with bowel cramps and frequent bowel movements, in others there are periods of constipation. But irritable bowel syndrome often has anxiety attached to it. They are often inseparable.
  • Eating disorders: here the person has an intense fear of turning fat. Persons with eating disorder often restrict their calories severely, even when they are underweight. They may exercise for hours with the hope to lose weight. Perhaps the most striking condition among eating disorders is anorexia nervosa, which often affects teenage females, but adult women are affected as well. Sadly many of these women die from starvation or starvation related diseases.
  • Sleep disorders: more than 40 million Americans suffer from chronic, long-term sleeping disorder. Another 20 million suffer from occasional sleep disorder. Often there is stress and anxiety that interferes with the normal sleep cycle.
  • Chronic pain: Pain is a common symptom; if it is associated with a surgical procedure or with an injury it is short lived and eventually goes away. With chronic pain, the pain is there all the time. People with arthritis or nerve injuries that did not heal often have this type of pain. Fibromyalgia sufferers also have this type of pain. When a person has an underlying anxiety disorder and gets chronic pain on top of this, the pain is amplified and becomes even more chronic. On the other hand anybody with chronic pain will suffer from a certain amount of anxiety just because of the chronicity of the pain.
  • Fibromyalgia: this chronic musculoskeletal pain disorder is a special form of chronic pain. About 20% of fibromyalgia sufferers have either chronic depression or chronic anxiety, which complicates the condition.
  • Substance abuse: about 20% of people with chronic anxiety disorders have an alcohol or substance abuse disorder; and 20% of people abusing alcohol or having a substance abuse disorder have a chronic anxiety disorder.
  • Stress: too much stress can turn into distress. Distress is an overdose of stress where the stressed person loses control of the situation. This can cause depression and anxiety. It can also cause physical illness.
  • Headaches: migraines, anxiety and depression seem to affect the same population group. Stress and anxiety can cause muscles around the neck to get into spasms and cause tension type headaches. But any headache can be brought on by anxiety.

Anxiety is common; biochemical brain abnormalities

Dr. Kharrazian has summarized in his book that Gamma-aminobutyric acid (GABA), which is a by-product of the brain cell metabolism is responsible for calming the brain (Ref.1). This mechanism is not working properly in people with anxiety. In many people with anxiety GABA is simply not produced enough to calm the brain or it gets inactivated too fast resulting in a lack of GABA with anxiety. The end result is the same: when there is a relative lack of GABA in the brain the person develops the symptoms of anxiety.

Disbalances in other neurotransmitters can also contribute to anxiety. Serotonin is a neurotransmitter that is essential to have for a stable mood and to prevent depression. It is produced in the mid brain. The pineal gland stores serotonin and makes melatonin out of it, which is essential for a normal sleep pattern. When serotonin is low, a number of things can happen. Anger and increased aggressiveness are associated with a lack of serotonin. But depression, obsessive-compulsive disorder, migraines, fibromyalgia, irritable bowel syndrome, bipolar disorder and anxiety disorder are also frequently observed. Many of these illnesses have been noted above to be associated with anxiety. Ref.1 also describes that stress inhibits the conversion of serotonin into melatonin, which explains sleep problems in persons who are exposed to chronic stress.

Anxiety is common; treatment options

What are the treatment options for a person with anxiety?

  1. Treatment with anxiolytics: It is tempting to just treat the symptoms in an anxious person. But just prescribing anxiolytics like benzodiazepines (like Xanax) will not cure anxiety, just relieve the symptoms for a while. Eventually the body gets used to benzodiazepine and requires higher doses to suppress the anxiety. This can be the beginning of drug dependency, which is not what the health professional or the patient wants. As mentioned above alcohol and substance abuse is already a problem for 1 in 5 people with anxiety.
  2. Treat sleep deprivation: An alternative is to concentrate on treating sleep deprivation helping the person to get a good night’s sleep. Melatonin at a dose of 3 mg at bedtime is a reasonable dose to help a person to fall asleep. If during the night the anxious person wakes up again, another dose of 3 mg of melatonin can be given. In addition, if an anxious person lies in bed and ruminates about various things that have happened during the day, a dose of valerian root (500 mg or even 1000 mg) can be useful. Dr. Datis Kharrazian describes in Ref.1 that valerian root increases GABA at the GABA receptor site. Research has also shown that valerian root slows down the breakdown of GABA. Although GABA is available in health food stores, GABA does not get absorbed through the blood/brain barrier easily. Only patients with autoimmune problems have a leaky blood/brain barrier and GABA can get through, but this is not a good approach to take for treating GABA deficiency. When you take GABA as a supplement, it wears off after a few days and loses its effect. It is wiser to stay away from GABA.
  3. Cognitive therapy and behavioral therapy has been proven to help the person with anxiety. Often psychologists specialize in these treatment methods. Meditation and counseling therapy will also help.
  1. Antidepressant therapy: In anxiety cases where depression is part of the psychological make-up antidepressants may have a place for a period of time. The FDA issued a warning in October 2004 about antidepressant medications, including SSRIs. These may lead to suicide and suicidal behavior in a small number of children and adolescents. But there is no way of predicting who will be affected this way. The antidepressant medications are still available and are still prescribed by many physicians.
  2. A balanced diet like a Mediterranean diet will ensure that the nutrients that are required to make GABA will be provided. Added sugar should be avoided as it may contribute to anxiety from blood sugar fluctuations.
  3. Yoga and biofeedback: Yoga with an emphasis on breathing techniques can also be useful. Biofeedback methods are useful as well.
Anxiety Is Common

Anxiety Is Common

Conclusion

Anxiety is common, but also very complex, as explained above. 74.8 million Americans suffer from the various forms of anxiety mentioned. Psychosomatic disease often involves anxiety as well and it can be difficult to sort out the symptoms of patients afflicted with physical illness and anxiety. Repeat visits to the treating doctor will eventually help sort these problems out. The physician will rule out any physical problems first by doing lab tests and imaging studies.

Treating anxiety should focus on reestablishing a healthy sleeping pattern. Self-hypnosis tapes or discs are useful. Melatonin and valerian root have their place. Cognitive-behavioral therapy will help the patient to reestablish clear thoughts and minimize the anxiety symptoms. With this approach the patient will often be able to overcome anxiety. There are no instant solutions, but with time and persistence the patient will be able to take back control of his or her life.

References:

Ref. 1: Dr. Datis Kharrazian: “Why Isn’t My Brain Working?” © 2013, Elephant Press, Carlsbad, CA 92011

Jul
16
2016

Mediterranean With Healthy Fat

If you want to lose weight, have you considered eating Mediterranean with healthy fat? A lot has changed in recent years regarding recommendations for healthy food intake. In the eighties and nineties the low fat diet was recommended, which unfortunately was high in carbs and led to obesity. What we have learnt from this is that carbohydrates that get broken down in the gut into sugar are converted into fatty acids and stored as fat.

Studies regarding diets with unhealthy and healthy fats

  1. Here is a prospective study that followed 120,877 U.S. women and men over a longer time. Every 4 years it was noted that for potato chips 1.69 lbs. were gained, for potatoes 1.28 lbs., for sugar-sweetened beverages 1.00 lb., for unprocessed red meats 0.95 lb. and for processed meats 0.93 lb. On the other hand from vegetables there was a weight loss of −0.22 lb., for whole grains −0.37 lb., for fruits −0.49 lb., for nuts −0.57 lb. and for yogurt −0.82 lb. Cheese was also investigated and was found to be mostly neutral in terms of weight gain, while butter did cause weight gain.
  2. In a study from Spain that was published in the Lancet in June 2016. 7447 asymptomatic men (aged 55–80 years) and women (aged 60–80 years) were followed for about 5 years. They all had type 2 diabetes and three or more cardiovascular risk factors. They were randomly assigned to three Mediterranean diet types: a Mediterranean diet with olive oil, a Mediterranean diet with nuts and a control group on a low fat Mediterranean diet. The interesting finding after 5 years was that both the patients on the Mediterranean diet with nuts and with olive oil lost some waist circumference. Their weight loss was 0.95 lbs. for the olive oil group and 2.82 oz. in the Mediterranean diet group with nuts. The Mediterranean diet group with olive oil had lost 0.22 inches in the waistline, the other group on nuts lost 0.38 inches. These are hardly impressive losses! The researchers concluded that fat restriction is not necessary on the Mediterranean diet, as there was no weight gain with unrestricted healthy fats after 5 years.

Dr. Dariush Mozaffarian, a cardiologist and epidemiologist of the Tufts Friedman School of Nutrition Science & Policy wrote an editorial regarding this Spanish study: ”A handful of nuts may be 160 calories, which is more calories than a can of Coke, but that doesn’t mean the can of Coke is a better choice”. He added: “Salt, sugar, starch, processed food and trans fats should be off the menu, not fat. Healthy foods are healthy foods, and bad foods are bad. It doesn’t matter, if the food is low fat or high fat. This is a separate issue.”

Mediterranean With Healthy Fat

Mediterranean With Healthy Fat

Conclusion

When wanting to lose weight, the key is to pay attention to your carb intake. Make sure it consists of unrefined carbs. You will do this if you eat vegetables and fruit. Cut out sugar and starchy foods as much as you can. Have lean, clean meats, but avoid red meat except perhaps for every two weeks some grass fed beef. Eat fish (important for its content of omega-3 fatty acids), also enjoy yogurt, nuts, olive oil and avocados. It is an extra benefit if you add regular exercise to this as well. You will notice that you gradually shed the unnecessary pounds. This is not a program for just a month or two. To stay well, make it a new lifestyle!

Jul
09
2016

Avoid That Heart Attack

Recently Dr. Mark Hyman mentioned a 7-point program to avoid that heart attack. If you follow the recommendations below, chances are that you do not only avoid heart attacks, but also strokes, high blood pressure, diabetes and obesity.

The Potsdam (or EPIC) study has shown that adhering to 4 simple things can reduce

Diabetes by 93%

Heart attacks by 81%

Strokes by 50%

All cancers by 36%.

What were those 4 points?

  1. Not smoking
  2. Exercising 3.5 hours a week
  3. Eating a healthy diet
  4. And maintaining a healthy weight

So with a few more points added it is no wonder that the figures can be even more impressive.

Other studies have also shown the importance of lifestyle changes to improve health outcomes; the INTERHEART study was based on 30,000 people in 52 countries that were followed along. Researchers found that 90 percent of all heart disease could be prevented by simple lifestyle changes.  I have added another point, regular exercise that has been proven to be very effective in preventing many diseases.

So, what are the 8 points that can assure that our health improves?

  1. Avoid that heart attack with a colorful, plant-based diet

Your dietary intake is important, because it provides all of the building blocks for your body. You want whole foods that are rich in phytonutrients. Often rainbow colors are mentioned, because the more varied your vegetables look, the more balanced the micronutrients, vitamins and minerals in the food items. Below we will learn that we want to avoid processed foods and hydrogenated fats, but we want to increase fiber and omega-3 fatty acids.

  1. Avoid that heart attack by stabilizing your blood sugar

Never eat refined carbs alone, as this goes chases up your blood sugar levels and causes unhealthy insulin reactions. Too much insulin production causes inflammation in the body, which can cause inflammatory bowel disease, arthritis, clogged arteries with heart attacks and strokes and Alzheimer’s disease. You want to balance complex carbs from vegetables with healthy fats and clean protein in every meal. Avoid sugars- no matter whether it is “natural brown” or white sugar and refined carbohydrates. Your pancreas does not differentiate between honey and other sugars, and it will react the same way!

  1. Avoid that heart attack by increasing fiber intake

The more fiber you can tolerate, the better. 50 grams would be ideal, but not everybody can tolerate this due to bloating or a queasy stomach. But even if you can add 5 or 10 grams of fiber per day, this is progress. Fiber decreases LDL cholesterol by intervening with the enterohepatic pathway. Fiber is found in nuts, beans, vegetables, seeds and berries that have lower sugar in them. You can also take a fiber supplement directly like psyllium husk.

  1. Avoid that heart attack by cutting out processed foods

Processed foods and junk foods are popular as they fill you up fast when you are hungry. But they need to be avoided at all costs. Sodas, juices and diet drinks affect your sugar and fat metabolism. The extra calories that come from sugary drinks are the biggest contributors to diabetes, heart disease and obesity. Even 100% fruit juice is not healthy, because all of the fiber is removed and you are drinking sugar water to which your pancreas reacts by producing extra insulin. As already discussed the extra insulin just causes inflammation. May I suggest a homemade lemon juice that you make by squeezing ½ lemon into a glass; add a tiny bit of Stevia for sweetening and sparkling mineral water. This is a healthy drink without sugar. You can drink this as often as you want. Another component of processed food are omega-6 fatty acids. They are in processed foods, because they increase the shelf life in stores. But they cause inflammation in the body unless balanced by omega-3 fatty acids (see below).

  1. Avoid that heart attack by increasing omega-3 fatty acids

Fish and seafood provide you with healthy omega-3 fatty acids. Unfortunately not all fish are healthy. Tuna is a predator fish that accumulates a lot of mercury from the polluted oceans. As a result of this it is not on my fish list. I prefer wild salmon. I also take molecularly distilled fish oil, which has omega-3 fatty acids in it. Many processed foods contain only omega-6 fatty acids, because this is the cheapest way to produce them (they are based on vegetable oils). Also avoid soybean oil, which is the most popular oil in the last few decades to foul up the omega-6 to omega-3 ratio. This ratio should be 1:1 to 3:1, but many Americans’ omega-6 to omega-3 ratio is 6:1 to 18:1. Omega-6-fatty acids cause arthritis, heart disease and strokes. Instead you want to eat healthy fats like omega-3 fatty acids contained in nuts and fish. You can also add molecularly distilled, high potency omega-3 fatty acids as a supplement to help restore the balance between omega-6 and omega-3 in your food intake.

  1. Avoid that heart attack by eliminating all hydrogenated fat

Hydrogenated fat like margarine has been shown to cause accelerated hardening of the arteries, which causes heart attacks and strokes. Read labels and eliminate any food that contains hydrogenated fats. If the label indicates that you are dealing with a product containing ”partially hydrogenated oil”, stay away from it as well! Butter from grass fed cows is a healthy fat. Olive oil and coconut oil are both good cooking oils. Olive oil is also good in salad dressings.

  1. Avoid that heart attack by keeping alcohol to a minimum

The problem with alcohol is that it is a cell poison. On the other hand small amounts have been show to reduce heart attacks and strokes (one glass for women, two glasses for men per day). However, due to the cell poison effect even low amounts of alcohol contribute to cancer causation, and as a result of that alcohol remains a problem. If you must consume alcohol limiting the intake to minimal amounts is prudent. In women ovarian cancer can be caused by alcohol and men prostate cancer. In both sexes pancreatic cancer can be caused by alcohol. Higher amounts of alcohol raise inflammation with elevation of blood pressure, heart attacks and strokes. One recommendation: either consume no alcohol or use alcohol in moderation. One glass does not kill you, but several ones may do it over time!

  1. Avoid that heart attack by exercising regularly

Regular exercise is yet another factor that can help you to reduce heart attacks, strokes and cancer even further. I added it as point 8, because it is fundamentally such an important preventative factor. Some studies have shown as much as a 50% drop in many diseases simply by introducing regular exercise.

Avoid That Heart Attack

Avoid That Heart Attack

Conclusion

It is all about lifestyle factors. Pay attention to your diet. Add fiber, subtract sugar. Avoid processed foods, omega-6 fatty acids and hydrogenated fat. Have enough omega-3 fatty acids as fish and supplements. Keep alcohol to a minimum. Your benefits from changing these lifestyle factors, result in huge benefits. You are avoiding 90% of diabetes, 80% of heart attacks, 50% of strokes and 35% of cancers.

Jul
02
2016

Zika Virus

Recently the question was asked on the news whether it was safe to go to the Olympics in Brazil; so here is some background information about the Zika virus. Zika virus was first isolated from mosquitoes in a forest named Zika forest in Uganda, which was in 1947.

Zika virus belongs into the virus family of Flaviviridae. Other members in that family are dengue fever, West Nile virus, yellow fever and Japanese encephalitis. Since the 1950’s Zika virus has occupied a narrow equatorial belt around the globe (Africa and Asia). But between 2007 and 2016 it spread further to the Americas and to the Pacific. Specifically French Polynesia, the Cook Islands, Easter Island and New Caledonia were included. Since May 2015 Brazil has joined the countries where mosquitoes are infected with Zika virus. This is an important point to know for the coming up Olympics in Rio on August 5 to 21, 2016.

Symptoms of Zika virus

For most people, particularly the young and middle aged Zika may not be that symptomatic. The most common symptoms are a fever, a skin rash, joint aches and red eyes (conjunctivitis). However, when a pregnant woman gets Zika virus, this will likely affect the fetus and will lead to a baby born with a small head (microcephalus), a severe complication from Zika virus. When a woman contracts Zika virus, the virus disappears after about one week. But in men the virus seems to stay longer, particularly in semen. This is why the CDC recommends for men using a condom or refraining from sex when returning from a holiday in a Zika endemic area. It may take up to 8 weeks for the semen to no longer be infective. The CDC recommends that a man who has come down with Zika to use a condom for 6 months.

Treatment of Zika virus

Make sure you get lots of rest. Take acetaminophen for fever or pain. Don’t take aspirin (ASA) or anti-inflammatory medication. Be aware that for between 1 and 3 weeks your blood likely is infectious. You want to avoid being bitten by a mosquito and it will be sensible to use insect repellant. The same insect could have bitten another person and spread the virus this way. A person who gets the Zika virus depends on the immune system to overcome the infection as there is no cure for this viral infection.

At this point no vaccine against Zika exists. There is research in an attempt to develop a Zika vaccine, which may become available in 2 to 3 years.

Zika virus risk with travel

If you travel to endemic areas, but visit mountainous areas above an elevation of 6,500 feet (2,000 meters) you are safe from Zika transmitting mosquitoes as they do not survive in these heights.

With regard to the Olympic Summer Games in Rio 2016 the CDC recommends to take a few precautions. Use insect repellents. Be aware as a woman that men infected with Zika virus can transmit the virus through sex. If you want to protect yourself from the risk of giving birth to a child with microcephaly, you may decide to use the birth control pill and ask your partner to use a condom. When you return back home, do not plan for a pregnancy for 6 months to avoid the risk.

The only recommendation for the Olympics by the CDC is that pregnant women should categorically not go to the games for fear of getting Zika infection resulting in a bad outcome of the pregnancy with microcephaly.

Microcephaly and other brain abnormalities from Zika virus

The CDC has stated that it is now established that Zika virus can cause microcephaly, but that it likely does not do so in all cases of Zika virus infection.

We know from German measles (rubella) that it can cause serious health risks for the fetus including death.

Zika is similarly neurotropic, meaning that it likes to multiply in nervous tissue including the brain. With rubella there is a vaccine available, which has made it much safer for pregnant women. But with Zika no vaccine is available. The only prevention is to stay away from endemic Zika areas and otherwise use reliable birth control methods.

Zika Virus

Zika Virus

Conclusion

I have briefly reviewed Zika virus in this blog. Unfortunately there are still many gaps in the knowledge of this disease. We need an effective Zika virus vaccine. It would also help to have antiviral antibiotics. All this needs to be researched. For now we need to use prevention and avoid endemic Zika regions by reading updates by the CDC.

Jun
25
2016

Prevent Unhealthy Aging

We know that stress can age you prematurely, but what do we need to do to prevent unhealthy aging? This is exactly what this review by cardiologist Dr. Joel Kahn has done. It points out that the right lifestyle makes the difference.

Studies showing how to prevent unhealthy aging

Several studies have shown how to avoid getting heart disease, cancer and diabetes.

  1. Kahn reported that in 2001 the Harvard School of Public Health published a study where 84,941 healthy female nurses had been followed who were free of heart disease, cancer and diabetes at baseline. But only 3.4% of the 84,941 women managed to stay healthy after 16 years of the study. The secret? Their body mass index (BMI) was less than 25.0, their diet was high in polyunsaturated fat and fiber, low in trans fat and low in glycemic load, they engaged in regular moderate exercise with a minimum of 30 minutes per day; they did not smoke and they drank ½ an alcoholic drink per day. Their risk to get diabetes was 91% lower than the rest of the study. This shows you how powerful lifestyle choices are.
  2. In 2004 an international study (the INTERHEART study) reported in the Lancet the lifestyle of 15,152 cases that developed heart attacks in 52 countries with 14,820 controls who did not have heart attacks. The researchers found 9 risk factors that accounted for 90 to 95% of the heart attacks. They were smoking, elevated cholesterol risk ratio, diabetes, high blood pressure, abdominal obesity, stress, low intake of fruit and vegetables, high alcohol intake and lack of physical exercise. Obesity was considered a high risk when the waist circumference measured more than 35 inches in a woman or more than 40 inches in a man. All these 9 risks can be eliminated by lifestyle changes.
  3. The 2006 Health Professional Study spanned over 16 years in a group of 40 to 75 year old doctors without a heart attack at baseline. It noted that male doctors who were lacking the 5 heart attack risk factors had 87% less heart attacks than controls without health lifestyles. What were the lifestyle factors? A body mass index (BMI) of less than 25, being a nonsmoker, being physically active for more than 30 minutes a day, having not more than moderate amounts of alcohol intake and having a diet that was more than 40% plant based.
  4. In 2007 a Swedish study reported on 24,000 women after menopause that had no heart attacks initially. After 6 years of follow-up 308 women developed heart attacks. An analysis showed what the risk factors were for those who developed heart attacks. Those who did not have these risk factors reduced their risk of getting a heart attack by 92%. What lifestyle factors were protective? Four factors were identified: a low-risk diet (consisting of high vegetable and high fruit intake, whole grains, legumes, fish and moderate alcohol intake), not smoking, walking or biking 40 minutes daily and a low waist circumference.
  5. In 2008 the Harvard University released a study that was a further follow-up of the Health Professional study with more than 43,000 men and also the Nurses’ Health Study with more than 71,000 women. The question here was what would prevent the development of strokes? The investigators found that in both groups stroke risk could be reduced by 50% when the following 5 lifestyle factors were adhered to: no smoking, keep the BMI below 25, exercise at least 30 minutes daily with moderate activity, don’t exceed a modest alcohol intake, have a diet intake in the top 40% of fruit and vegetables and whole grains.
  6. A 14 yearlong study from the Netherlands was published in 2014, where almost 18,000 men and women without heart disease at the beginning of the study were followed. More than 600 heart attacks occurred throughout the study. People who stuck to 4 lifestyle habits reduced their heart attack rates by 67%; if they adhered to 5 lifestyle factors they reduced the heart attack rate by 83%. The 4 initial lifestyle factors were: doing an average of 30 minutes of physical activity per day, eating a Mediterranean style diet rich in fruit and vegetables and whole grains, not smoking and having more than one alcoholic drink per month. This gave you a reduced risk of your heart attack rate by 67%. Add one more good habit: sleep 7 or more hours per night on average. This reduces the risk of you getting a heart attack by 83%!
  7. A Swedish heart study with initially more than 20,000 men was going on for 11 years. There were 5 lifestyle habits the investigators identified as essential to reduce heart attack rates. Unfortunately only 1% of the study group adopted all 5 lifestyle factors, but they dropped their chance of getting a heart attack or dying of a heart attack by 86%. The lifestyle factors were: a diet rich in fruit and vegetables, legumes, nuts, whole grains and low fat; not smoking, moderate alcohol consumption, thin waistline and more than 40 minutes of physical activity.

Preserving health and vitality to prevent unhealthy aging

There is a clear pattern in all of these large studies. A healthy lifestyle preserves your health by keeping your joints and muscles in good working order. Your heart and lungs are staying well conditioned, because you engage in cardiovascular training every day. This keeps your nitric oxide going, which is an important signaling molecule that in turn reduces your blood pressure.

When we remove disabling diseases like strokes and heart attacks and prevent diabetes from developing, life expectancy is increasing. When people remain physically active even in old age, this translates into fewer disabilities and less frailty. Even Alzheimer’s disease is observed to occur less when good lifestyle habits are adhered to.

Prevent Unhealthy Aging

Prevent Unhealthy Aging

Conclusion

The studies cited here show how lifestyle factors can make a significant difference in preventing heart attacks and strokes. In the past even doctors ignored the risk of smoking. A few years back conventional medicine negated that lifestyle factors could make a difference. Now we have more studies than we need to prove that this is so. It is more important that we adhere to as many of the lifestyle factors identified in these studies to make a real difference in our lives. We also need to set an example to the next generation and to our peers. Adopting healthy lifestyle factors has to become a cultural habit for society at large. This will help reduce healthcare costs, but most importantly this will help you and me to live longer, healthier lives.

Jun
18
2016

High Vitamin D3 Prevents Cancer

In the last few years we learnt a lot about vitamin D3, but the newest thing is that high vitamin D3 prevents cancer.

Researchers at the University of California, San Diego School of Medicine reported that with respect to several cancer types higher doses of vitamin D3 led to less cancer over a period of time.

The cancers investigated were colon cancer, breast cancer, and lung and bladder cancer. As people do absorb vitamin D3 differently, the researchers found that the best way to measure vitamin D3 concentration in the body is to use serum 25-hydroxyvitamin D (25(OH)D). In the past not much attention was paid to this matter. However, several studies including the present study showed that in patients who had a lower level of 20 ng/ml cancer rates were higher.

The researchers used data from two prior studies, a randomized clinical trial of 1,169 women and a prospective cohort study of 1,135 women. The researchers found that the age-adjusted cancer incidence was 1,020 cases per 100,000 person-years in the randomized clinical trial, called “Lappe cohort”. The other prospective cohort study was called the “GrassrootsHealth cohort” with an age-adjusted cancer incidence of 722 per 100,000 person-years. The interesting fact was that the Lappe cohort median blood serum level of 25(OH)D was 30 nanograms per milliliter, while the GrassrootsHealth cohort had a higher level of 25(OH)D of 48 ng/ml. This likely explains the lower cancer rate in the GrassrootsHealth cohort. In order to increase the statistical significance the two trials were combined. The striking finding was that above 40 ng/ml the overall cancer risk was more than 71% lower than for the group of people whose level of 25(OH)D was 20 ng/ml or lower. The above ScienceDaily article was based on this scientific study.

Other studies showing high vitamin D3 prevents cancer

  1. In a 2015 study Afro American men were found to have 71% less prostate cancer, if their serum 25-hydroxyvitamin D level was at least 30 ng/ml or higher.
  2. This 2006 study reported a 14-year prospective follow-up in men where all cancers were counted and blood serum 25-hydroxyvitamin D levels were correlated to cancer incidence. An increase of 25 nmol/L (=10 ng/ml) in predicted serum 25(OH)D level was associated with a 17% reduction in total cancer incidence, with a 29% reduction in total cancer mortality and a 45% reduction in digestive-system cancer mortality. These investigators stated that it takes about 1500 IU of vitamin D3 increase per day to achieve an increment of serum 25(OH)D increment of 25 nmol/L (=10 ng/ml).
  3. A publication from the University of Arizona Cancer Center in Jan. 2016 is more critical of the evidence regarding vitamin D3 and the claim that it lowers cancer rates. They reviewed the cancer literature and found that for colorectal cancer there is a clear inverse relationship between serum 25(OH)D levels on the one hand and rates and mortality of colorectal cancer on the other hand. However, with breast cancer the literature was more divided. Only higher vitamin D levels were related to a lower risk for progression of breast cancer and a lower mortality rate. Randomized, double-blind clinical trials with regard to breast cancer failed to show effectiveness on cancer prevention or reduction of mortality. For prostate cancer conditions were similar with the exception of a study using 4000 IU of vitamin D3 per day, which inhibited progression of prostate cancer.
  4. In a mouse model using a carcinogen to induce ovarian cancer there was an inverse dose-relationship between vitamin D3 and ovarian tumor development both in tissue culture and in the animal.

How high vitamin D3 prevents cancer

  1. Several studies have attempted to speculate how vitamin D3 may prevent cancer. Chirumbolo summarized the literature and noted that vitamin D3 has been shown to function as an immune cytokine stimulating the immune system non-specifically.  Vitamin D3 is also anti-inflammatory and counters insulin resistance and inflammatory kinins in obesity. Flavonoids with their antioxidant activity are also cancer preventing. As we know that low levels of vitamin D are associated with higher cancer frequency it is important to use vitamin D3 as supplements in our diet.
  2. This Chinese study examined the effects of vitamin D3 on cancer prevention. It found that vitamin D3 combines three specific actions in one. Vitamin D3 is anti-proliferative meaning that it stops uncontrolled cell division. Secondly, it has an apoptotic (cell death) effect, which means it supports the removal of cells that are dying. If they are dying, but not removed, cancer can occur from these cell remnants. The third effect of vitamin D3 is that it has differentiating effects in several malignant cell types. When cancer cells are non-differentiated (=more immature cells) cancer can multiply quickly. When cancer cells are becoming more specific cells uncontrolled multiplication is much more difficult. This is an effect that controls the speed by which cancer cells divide and how quickly cancer metastasizes.
High Vitamin D3 Prevents Cancer

High Vitamin D3 Prevents Cancer

Conclusion

There still is some confusion about the effects of vitamin D3 regarding cancer prevention. In colorectal cancer the statistics are clear: vitamin D3 can significantly prevent colorectal cancer to a large extent. There are also preventative effects in breast cancer and prostate cancer, but individuals may have to take at least 4000 IU of vitamin D3 or more. This is particularly true in higher latitudes where sunlight exposure is lower in the wintertime. Also, people absorb vitamin D3 differently. For this reason it is important to at least check your serum 25-hydroxyvitamin D levels on a few occasions. This will tell you whether your vitamin D3 supplementation is sufficient. Aim for levels in the 50-80 ng/ml, which is health promoting.

Apart from cancer prevention vitamin D3 is also important for prevention of cardiovascular disease (particularly in diabetics), osteoporosis and Alzheimer’s disease.

Jun
11
2016

Drugs Can Cause Dementia

An April 2016 study from Indiana University found that drugs can cause dementia. There were 451 people enrolled in the study with an average age of 73. 60 of them were taking at least one or more anticholinergic drugs. Anticholinergic drugs are drugs that inhibit the neurotransmitter acetylcholine in nerves or in the brain. The end result is that spasms in the stomach, bowel or bladder are relieved. Also the many over-the-counter sleep medications that may contain anticholinergic drugs help you to fall asleep easier. In the above-mentioned study researchers measured the effects that the drugs have, using different tests. They used memory and cognitive tests to check for memory loss, reasoning and judgment. PET scans were used for measuring brain metabolism. MRI scans were used to look for structural brain changes.

Results on how anticholinergic drugs can cause dementia

Memory tests and cognitive function tests showed that those taking anticholinergic drugs did worse on memory tests, verbal reasoning, problem solving and planning. The PET scan showed that glucose utilization by the brain was down in those who were taking anticholinergic drugs. The hippocampus was particularly affected with lower glucose utilization. This is the center where short-term memory is processed. It is also the area where Alzheimer’s patients have been found to have problems with early memory loss.

MRI scans showed that there were structural brain changes in the patients that were using anticholinergic drugs. Their brains had reduced brain volume (brain atrophy) and the brain cavities in the brain, called ventricles were enlarged. Overall this meant that their brains had much less brain cells when compared to controls that did not take anticholinergic drugs.

In a 2013 study from the Indiana University researchers had established that it took only 60 days of taking cholinergic drugs to cause cognitive problems. Using drugs with only weak anticholinergic side effects, it took up to 90 days before the same cognitive deterioration could be measured.

The researchers concluded that it would be wise for physicians to consider switching a patient to medication that does not include anticholinergic side effects to prevent development of dementia or Alzheimer’s disease.

Anticholinergic drugs can cause dementia

In the study above it was stated that it was the group of anticholinergic drugs that was particularly problematic. These are over-the-counter-drugs like sleep aids, antihistamines, and incontinence drugs etc. that were having anticholinergic side effects. The more of these types of drugs are taken, the more interaction can take place, leading to full-blown anticholinergic symptoms. As people age, they collect more and more symptoms and diseases. Physicians tend to treat the symptoms with various medications, so it is not unusual for an elderly person to be on 5 or 6 different drugs. If one or more of these drugs have anticholinergic side effects, this can add up and cause the kind of observations the above mentioned clinical study showed: dementia symptoms and proof that the brain metabolism has been slowed down. The brain also experiences the structural changes of dementia that I mentioned.

Possibility that herbs and drugs can cause dementia

The problem does not stop here. It is possible that over-the-counter herbs that you may innocently get in the health food store can participate in the overall metabolic interaction of anticholinergic substances. Many herbs have pharmacological substances in them that have specific helpful effects. But whenever a drug or herb has a positive effect, quite often there is an undesirable effect or side effect.

Historically Belladonna is a poisonous plant that has medicinal values. Unfortunately many Belladonna preparations are available in health food stores that are not regulated by the FDA. Belladonna has strong anticholinergic side effects that interfere with other anticholinergic side effects.

There are many other herbs that are available without prescription.

Kava-kava is an herb and a hallucinogenic that has anticholinergic properties. Keep in mind that the more you use Kava-Kava, the more your brain gets shut down. Why? The anticholinergic effect of Kava-Kava shuts down acetylcholine, the main stimulus in your brain cells to help you think.

Passionflower is an herb that sedates and is often used as a tincture to help you to fall asleep. What is perceived as a natural effect is merely the anticholinergic effect on the central nervous system.

Hops is the calming compound found in beer. It is also often used together with other sedating herbal sleeping remedies in teas.

St. John’s wort is also on the list. In smaller doses this herbal antidepressant may be useful and may have less side effects than commercial antidepressants. But there are possible side effects of dry mouth and constipation, which are the result of the anticholinergic side effect.

Skullcap is often used in tea to help a person to fall asleep. But keep in mind that the effect of helping you fall asleep comes from the anticholinergic effect of skullcap on brain cells.

All of these herbs are not any different from the medications discussed earlier, except that they are a bit weaker with regard to the anticholinergic effect.

Street drugs can cause dementia

Many street drugs are sedating and they have anticholinergic effects. It is therefore no surprise that with chronic use of street drugs drug users can come down with dementia, even at a relatively young age. Long-term use of anticholinergic drugs is associated with delirium and dementia.

Particularly benzodiazepines, meperidine (an opioid), antidepressants and many other drugs when taken together cause dementia, in part because of additive anticholinergic activity.

In an Edinburgh study from England 34 deceased patients, who were heavily using street drugs were autopsied. Their brains were compared to healthy 16-year-old non-drug users. There was nerve cell damage in the brain area involved with learning, memory and wellbeing. The pathologist found the same dementia findings that would be present in much older Alzheimer patients. We have to conclude from this that the damage was done by the anticholinergic effect of the drugs that were used as a mix in the years prior to their deaths. There can be added toxicity to nerve cells from interacting drugs and their side effects.

Drugs Can Cause Dementia

Drugs Can Cause Dementia

Conclusion

Whenever you have a substance that helps to get you drowsy so you can sleep better, be careful and check that it is not because of the anticholinergic effect of an herb or an over-the-counter drug. Melatonin is an exception, because this is your body’s own sleeping hormone that your body knows. Whenever anticholinergic drugs or herbs act on your brain they can over time cause an irreversible brain atrophy, which can been shown by MRI scans as in the study mentioned above. This leads to cognitive problems including memory problems. PET scans have also shown a permanent slowdown of glucose metabolism of the brain cells of the hippocampus, where short-term memory is located. Without that function you get permanent dementia. Instead of being treated symptomatically ask your physician for the cause of your symptoms and have the cause treated. You may not always get the answer you need from conventional medicine. As the next step you may want a second opinion from a naturopath to see whether there would be an alternative treatment available that does not involve anticholinergic medications. Go to the root of the problem, avoid drugs that cause damage, and keep your brain healthy and your mental capacities without cognitive deficits!

Jun
04
2016

Genetic Screening For Better Health

Dr. Matt Pratt-Hyatt gave an overview about genetic screening for better health at the 23rd Annual World Congress on Anti-Aging Medicine on Dec. 13, 2015 in Las Vegas. The talk was entitled ”Genetic Screening: A Tool for Better Health with Age”. He showed that with more sensitive genetic screening techniques minor genetic changes can be detected. These are a lot more common than previously thought of. Matt Pratt-Hyatt, PhD is Associate Laboratory Director for the Great Plains Laboratory in Lenexa, KS.

Specifically, Dr. Pratt-Hyatt explained that single nucleotide polymorphisms, frequently called SNPs (pronounced “snips”) were the most common type of genetic variations among people. These genetic changes in the DNA often cause disease. Different types of genetic testing can identify the gene defects of SNPs. One of the questions is how aging can be better managed when genetic defects are known.

When it comes to our genetic material there are over 3 billion base pairs, all contained in 23 chromosomes. These are home to 20,000-25,000 genes, most of which are normal.

A gene has three regions all of which can have mutations. In the middle there is the coding region; one end is the regulatory region for transcription initiating; at the other end the transcription termination signals are located. Minor mutations in any of these regions can have major implications for the health of the individual or they can stay silent SNPs. SNPs are classified into missense mutation or nonsense mutation. This description just shows how intricate and complex the process of mutations can be!

Three types of sequencing are commonly used:

Three types of genetic screening for better health

  1. Sanger sequencing
 utilizes certain dyes that correspond to specific nucleotides of the DNA. The benefits of Sanger sequencing is that it can cover one gene completely. It can find previously unknown mutations. But the disadvantage of Sanger sequencing is that you cannot process a large number of genes.
  2. The Florophore-base detection looks at multiple SNPs in a single run. This method is cheaper than whole genome sequencing. But one of the disadvantages of Florophore-base detection
is that only a limited number of SNPs can be processed per run. It also can miss new mutations.
  3. Benefits of next generation sequencing 
are that it can look at 1000s of SNPs per run. It is much more accurate than previous technologies. A drawback
though is that the equipment is much more expensive.

Not all of these tests have to be done, but the physician can make the choice of the appropriate one for the patient. The following are some applications with regard to how genetic screening can be useful for better health.

Detoxification as part of genetic screening for better health

Since the 1970’s and 1980’s it has become clear that there are many steps in the detoxification process in the liver. It involves major enzyme systems that are controlled by the P450 genes. Several genetic defects are known that run in different families. These effects are very important for drug detoxification and metabolism. Any mutation in one of the P450 controlling genes will lead to accumulation of the drug that is normally detoxified by this enzyme system. As any drug has toxicity at higher levels, the consequence is possible toxicity, if the drug is not discontinued or lowered. When people age, they often have spontaneous mutations of the P450 detoxification system and this should be taken into account by doctors who prescribe medications. Common drugs that cause problems with the P450 controlled detoxification are antidepressants, the blood thinner Coumadin, the antibiotic erythromycin, the asthma medication Theophylline and many others.

Here is an example of how important this knowledge is in an elderly patient who was sent to the hospital with an irregular heartbeat. The electrocardiogram allowed a diagnosis of atrial fibrillation. The doctor treated the patient with a cautious loading dose of 0.5 mg of Coumadin in an attempt to thin the blood of the patient. This would prevent a blood clot or a stroke due to the arrhythmia. Normally a small dose like this would not do much in terms of blood thinning, as it would take several days of a low dose like this to achieve blood thinning. Unbeknown to the physician, this patient was different as he had a defect in the Cyp2c9 gene, a subtype of the P450 system. Very quickly the patient developed bleeding gums and bruising of the skin in various locations. When blood tests were taken, the INR, a measure of the clotting system, was 3.7, a value that should not have exceeded a level of 2 to 3. Genetic testing confirmed a homogenous mutation of the Cyp2c9 gene that explained the toxicity of Coumadin in this case, one of the many drugs that is detoxified by the P450 system.

Mental health as part of genetic screening for better health

Many mental illnesses can be caused by defects in various parts of the brain metabolism. This is particularly so when it involves the synthesis of brain hormones. If there are genetic defects, this can lead to the particular brain metabolism that is associated with depression or schizophrenia. Even dementia, Alzheimer’s disease and Parkinson’s disease can be caused by genetic defects. Methylation pathway defects are another source of possible genetic defects, which can affect multiple metabolic pathways. This is the cause of many diverse conditions like autism, diabetes and some hereditary cancers. The reason it is important to be aware of such genetic aberrations is that often vitamin B2, B6, niacin, vitamin B12 and the minerals magnesium and zinc can stabilize a person with methylation defects.

Cholesterol as part of genetic screening for better health

People with obesity have problems with their lipid metabolism, diabetes, high blood pressure and often heart disease and strokes. Changes in cholesterol metabolism are at the center of these problems. Cholesterol is one of the building blocks of cell membranes, and cholesterol is one of the normal components in the blood as long as the subfractions are properly balanced (LDL and the HDL cholesterol). Unfortunately many people have minor or major defects of the biosynthetic pathway of cholesterol. There are 5 genes involved in the acetyl CoA biosynthesis. 21 genes are involved in the main cholesterol biosynthesis pathways. Over 10 genes control cholesterol metabolites. Historically these genes were detected because of various familiar gene defects that caused problems with the biochemical processes surrounding cholesterol. Familial high cholesterol levels (familial hypercholesterolemia) is one of these common conditions.

Patients who have this condition will often have high cholesterol and also often have a family history of gall bladder surgery for gallstones and a history of premature heart attacks or strokes. Early diagnosis and careful clinical intervention can improve the outlook for many patients.

Genetic Screening For Better Health

Genetic Screening For Better Health

Conclusion

Not all genetic conditions can be helped by modern medicine. But many minor genetic abnormalities can be worked around or drug interactions can be avoided provided the genetic defect is known. It is encouraging that newer test methods have now shown success, as they are more affordable than in the past. As time progresses the price of these genetic tests will come down even further. Mental health, detoxification pathways and the metabolic syndrome of obesity are practical applications where genetic tests have significance.

May
28
2016

Two Sides Of Medical Marijuana

The newest craze is to treat menstrual cramps with medical marihuana, but there are two sides of medical marijuana. What women with menstrual cramps may not know is that it is estrogen dominance that is the cause of their symptoms. As women get closer to menopause they ovulate less often, and there are anovulatory menstrual cycles. This leads to a relative loss of progesterone from the corpus luteum that will form less frequently in the small cavity where the cyst with the egg was. Nature designed women’s menstrual cycle with mostly estrogen production in the first half of the menstrual cycle and mostly progesterone production in the second half of her cycle.

Other causes of estrogen dominance

When a woman gains weight, estrogen can also be produced in the fatty tissue due to an enzyme called aromatase. Androgenic hormones, which are testosterone-like and produced in the adrenal glands, get metabolized into estrogen through aromatase. This upsets the balance between progesterone and estrogen. Normally that balance when measured with saliva hormone tests should be higher than 200 to 1. But when progesterone production from the ovaries is missing, or when estrogen production is in overdrive through aromatase, estrogen is dominant. The progesterone to estrogen ratio drops below 200 to 1. This is bad news as it has consequences. It can cause a number of symptoms: migraine headaches, painful menstrual periods, endometriosis, and fibrocystic disease of the breasts with breast pain; even cancer can develop in the cervix, the uterus and the ovaries. Estradiol, the main estrogen compound in women, stimulates cells to divide, when it is not balanced by progesterone. Progesterone does the opposite: it balances the effects of estrogen.

Two sides of medical marijuana: treating symptoms

Drug companies always look out for symptoms that they can treat with a patented drug. The link at the beginning of this blog pointed out that “there are some very sick patients in need” to justify treating them with marijuana. This may relieve their symptoms for as long as they take the chemical compound. But it does nothing for the hormone imbalance. With the next menstrual cycle the symptoms will recur, and the marijuana will be consumed intermittently for years to come. What is worse is that the women think that nothing bad can happen to them: they are just relieving their symptoms. But as pointed out, unbalanced estradiol can give them migraine headaches. It can cause painful menstrual periods with or without endometriosis. Breast pain can be caused from fibrocystic disease. The worst of all is that after decades of estrogen dominance cancer of the cervix, cancer of the uterus and cancer of the ovaries can be caused. This is when drug manufacturers have unwittingly victimized their customers.

Proper treatment of menstrual cramps

1) Premenopausal women: The proper treatment for estrogen dominance because of a lack of progesterone in premenstrual women is to replace the progesterone deficit by bioidentical progesterone cream. Naturopathic physicians and anti-aging physicians understand this and treat it this way. Many practicing physicians including specialists, however, use anti-inflammatories and pain medications to treat this. Replacing the missing progesterone is causal treatment. Treating pain is symptomatic treatment. Treating the cause treats the medical problem properly; symptomatic treatment treats the drug company to a profit at the expense of the patient’s health.

2) Women with obesity: As explained already, estrogen dominance can also be produced from estrogen conversion of androgenic adrenal gland hormones due to aromatase in fatty tissue. The key here is to concentrate on watching the diet and exercising regularly. Even 10 to 20 pounds of weight loss can have significant effects on lowering estrogen production. The treating naturopath or anti-aging physician should measure progesterone and estrogen levels in a saliva hormone test. The progesterone to estrogen ratio should be calculated. If progesterone is missing, this can be added by giving a bioidentical progesterone cream or by taking oral micronized progesterone capsules at bedtime. As mentioned above, this is a causal therapy, and will in time not only cure the painful periods, but will prevent all of the other negative conditions mentioned. And most of all, there are no negative side effects, because the body knows the bioidentical hormones.

Two sides of medical marijuana: side effects of marijuana

Marijuana has real side effects. j can cause high blood pressure, dry mouth, headaches, dizziness, hallucinations, depression and sexual problems. It is unsafe with pregnancy, as it has been shown to be associated with childhood leukemia. Marijuana can cause rapid heartbeats and increases the risk of having a heart attack. Regular use of marijuana is associated with lung cancer and emphysema. There is an association of marijuana use and seizures: in some patients it makes seizures worse, in others it makes them better. But marijuana is a central nervous system suppressant. So it is imperative that you stop marijuana two weeks before any surgical procedure, as the anesthetic and other medicines given during surgery will also depress the nervous system.

Why the difference between hormones and marijuana?

You may ask yourself why there would be such a difference in the side effect profile of hormones versus marijuana? Hormones are natural messenger molecules in the body. They are designed by our genes to communicate between our brain, the hormone glands, and cells in organs with certain hormone receptors. This design helps to ensure optimal balance of our metabolic processes.

In contrast, marijuana is affecting cannabinoid receptors in the brain. There are several subtypes that are defined at this point. But these were only detected because researchers were curious what marijuana was doing. This research is in flux. We do not know enough about the long term side effects of marijuana. We do know that marijuana has central nervous depressive effects, because it is binding to these receptors. This makes these receptors not available for the normal brain function. One of these effects may even be that it would block pain perception for a period of time. But nobody knows how safe this is in the long term.

Another possible effect, which makes it to the media a lot, is a possible anti-cancer effect. Before you get your hopes up, read this thorough review of all the cancer research with cannabinoids. I am afraid that at this point there is no clear evidence to support that cannabinoids help fight cancer persistently. There are occasional cures reported, but this is not a persistent pattern.

Safety of synthetic hormones versus bioidentical hormones

You may have heard of the Women’s Health Initiative (WHI) that was abruptly ended in 2002. They used synthetic estrogens (derived from horses) and synthetic progestins (bad copies of progesterone). There results were breast cancer, uterine cancer, heart attacks and strokes that developed in patients who took these synthetic hormones. Originally the investigators wanted to show that HRT (hormone replacement therapy) would prevent heart attacks and strokes. It was supposed to also show that osteoporosis would be diminished. But the opposite was true! The synthetic hormones blocked the natural receptors, so the woman’s own hormones could not reach their target cells. Had the investigators used bioidentical hormones, the natural receptors would have been stimulated, and all of the research objectives would have been reached. The WHI was a huge debacle, which showed that drug sponsored research can lead to disasters. The only problem now is that women are scared, as they do not understand what hormones do. The bioidentical hormones, when balanced properly, are harmless. Synthetic hormones from drug manufacturers are interfering with the body’s hormone receptors causing all kinds of serious side effects including cancer. Bioidentical hormones don’t do that.

Two Sides Of Medical Marijuana

Two Sides Of Medical Marijuana

Conclusion

Those who like to push the sale of marijuana will minimize the side effects of marijuana. They will also push testimonials of women who have been helped with regard to painful periods.

You will rarely hear about women who had their hormones analyzed and had been replaced with bioidentical hormones to normalize their estrogen dominance. The latter approach is a safe approach with no side effects, because you are using natural hormones that stimulate your body’s hormone receptors. Synthetic hormones or marijuana are foreign substances to the body, partially blocking cell receptors, which blocks normal cell function. But nobody knows exactly what these chemicals do other than produce a myriad of side effects. Are you really willing to put your health at risk? After reading this, the answer should be clear.

May
21
2016

Arsenic In Rice

Recently news stories reported that there is arsenic in rice. This is important to know because in large parts of the world rice is one of the main food staples. But rice has also become an important side step from wheat for those who are gluten sensitive. Rice is one of the main ingredients in gluten free diets.

Source of arsenic in rice

Naturally high levels of arsenic in soil can be a source of high levels of arsenic in rice, although these cases are the minority. By and large high arsenic in rice comes from inadvertent, but deliberate human poisoning. As explained in the Consumers Report high arsenic values were found in rice grown in these states: Arkansas, Louisiana, Missouri, and Texas. These are the same states, where cotton was grown in the past. The U.S. has been the world’s leading user of arsenic. Since 1910 about 1.6 million tons have been used for agricultural/industrial purposes. Half of this was only used since the mid-1960s. Although arsenic use has been banned as an insecticide in the 1980’s, residues from the decades of use still linger on in agricultural soil today. The south-central region of the US was where cotton was produced for a long time. This is a crop where heavy treatment with arsenical pesticides was used for decades in an attempt to combat the boll weevil beetle.

Arsenic containing insecticides are also used in the fruit growing industry. This explains the presence of arsenic in grape juice and apple juice.

Another source are arsenic compounds in chicken feed that is used to promote growth. As a result arsenic can then be found in chicken meat. For this reason alone it is recommendable to eat organic chicken that is free of arsenic.

Keep in mind that brown rice has persistently tested higher in arsenic than white rice.

Alternatives to rice

As drastic as it may sound, your safest approach is to avoid all cereals. This keeps you away from the various forms of gluten proteins that are present in all cereals, even in corn and oats. You can fill your plate safely with organic vegetables like broccoli, bell peppers, asparagus, cauliflower and many others. You also can eat all lettuce varieties including spinach, arugula, Romaine lettuce, head lettuce, super greens and more.

Many people are addicted to grains and grain products, but they can do more harm than good. Wheat has the highest concentration of gliadin, but rye has its own gliadin protein, so does barley. It is much safer on the long term to stay away from them all. Not everybody will agree with me on that, but as far as I am concerned I can live this way quite well. High endurance athletes who seem to need more carbs for fuel, could have sweet potatoes for example instead of grains and do well on that.

Eliminating exposure from arsenic in rice

Now that we know that brown rice has more arsenic in it than white rice, and that Arkansas, Louisiana, Missouri, and Texas have high arsenic because of residual arsenic in their soils, it is relatively easy to choose the right rice, if you decide to consume it. This report explains what are safe rice alternatives and what rice is the safest.

Basmati rice from California is the lowest in arsenic. Quinoa and millet are rice alternatives that are low in arsenic. Low-arsenic buckwheat is not related to wheat and is gluten free.

In this context it is interesting to note that even organic rice cannot be trusted with regard to arsenic toxicity. The last link notes that the rice grains accumulate arsenic from the soil. If the soil or the water are contaminated all of the other organic culturing methods are not enough to protect the crop from arsenic accumulation.

If you are serious about eliminating arsenic from your food, you may want to consider avoiding grains altogether.

What are signs of toxicity from arsenic in rice?

Arsenic toxicity can be acute or chronic. Most of today’s arsenic toxicity is chronic. Arsenic gets slowly accumulated from foods we eat that are contaminated such as regular chicken that was fed arsenic compounds for growth, rice, non-organic grape juice and apple juice. Studies in Argentina and Chile where in some areas drinking water has naturally high arsenic levels, showed that chronic exposure to arsenic is a cause for lung and bladder cancer.

A fast heart beat, low blood pressure and shock can be symptoms of arsenic poisoning. The mental status may be changed, and seizures can occur. A person may present with delirium with irrational thoughts and behaviors. The patient may present with a cholera-like clinical picture with vomiting and severe diarrhea leading to marked dehydration. Liver and kidney damage can occur. The finger nails show white lines across, called Mees lines.

Treating toxicity from arsenic in rice

A study of 3633 individuals showed that those who ate 1 helping of rice per day had a urinary arsenic level that was 44 percent greater than those who did not consume rice. People eating two or more rice products had 70% higher arsenic urine levels that those who ate no rice. It is clear from that study that avoidance of rice is a powerful tool treating chronic arsenic poisoning. With respect to drinking apple or grape juice the total urinary arsenic levels were nearly 20 percent higher than those who did not consume apple or grape juice.

There are natural substances that are good chelators and that have been tested to eliminate arsenic from the body.

Here are natural chelators: milk thistle seed extract, dandelion leaf extract, garlic bulb (allium sativum), cilantro leaf extract, L-glutathione, N-Acetyl-L-Cysteine.

Intravenous chelation using EDTA is the gold standard that is used to get rid of heavy metals including arsenic and lead. Dr. Cranton noted in his book on chelation therapy that arsenic was excreted in the urine within 5 hours of intravenous EDTA chelation (Ref. 1).

Other supportive steps are to check your drinking water for high arsenic and lead levels, particularly if you are on a well. Change the way you cook rice, if you want to continue to eat rice. Rinse the rice with 6 times the amount of water and discard the water. This will lower the arsenic content of the rice by about 30% while you deplete the rice only marginally of vitamin and mineral contents.

Avoid drinking non-organic grape juice and apple juice. This eliminates a significant amount of arsenic from your diet.

If you eat more than two or three helpings of rice per week, consider replacing some rice portions by arsenic-free grains. For those on a gluten-free diet quinoa, millet, and amaranth are good replacement options.

Arsenic In Rice

Arsenic In Rice

Conclusion regarding arsenic in rice

It is sad to notice that the food industry is inadvertently trying to poison us with arsenic. I am sure this is not deliberately done. But it is necessary for us to defend ourselves and think about the food we are eating. Is it safe? Are we taking the right steps to minimize exposure to arsenic? I have covered this from various angles, avoidance of high arsenic food items, chelating out accumulated arsenic, and preventing further exposure to arsenic. I hope this has been helpful and has shown you what you can do in your particular case.

References:

Ref.1: Special Issue of Advancement in Medicine “A Textbook on EDTA Chelation Therapy”, edited by Elmer M. Cranton, Spring/Summer 1989. Human Sciences Press Inc. NY, USA.