• Replacing Part Of Red Meat With Fish Shows Health Benefits

    Replacing Part Of Red Meat With Fish Shows Health Benefits

    A Danish study has shown that replacing part of red meat with fish shows health benefits. The research was done by a PhD student and pointed out that men above the age of 50 were particularly benefitting from fish substituting part of red meat in their diet. Women in the childbearing age also benefitted greatly. … [Read More...]

  • How Can We Prolong Our Lives?

    How Can We Prolong Our Lives?

    The question “How can we prolong our lives?” is something that fascinates many people. It is not one thing, one activity, one diet, or one lifestyle factor that determines longevity. It is the combination of all of the things listed below that are necessary. Longevity is partially inherited from your mother The … [Read More...]

  • More Obesity In Rural Areas

    More Obesity In Rural Areas

    A new study was published May 2019 in the magazine Nature showing that there is now more obesity in rural areas. In the mid 1980’s when the first reports came out about obesity, this was not the case. It actually was the opposite: there were more cases of obesity in cities compared to rural areas. The study was also … [Read More...]

  • The Foods That Are Killing Us

    The Foods That Are Killing Us

    There is an article in a CNN report talking about the foods that are killing us. This review is based on an article in the Lancet. The Lancet study was based on a global review of eating habits in 195 countries. The question in the study was which of 15 food items caused the diseases that killed people. The answer … [Read More...]

  • A Pill Against Obesity

    A Pill Against Obesity

    At the 26th European Congress on Obesity in Glasgow, Scotland a pill against obesity was introduced. Here is a report about this on CNN. The biotechnology company, Gelesis had funded the research. This company also developed the product. The FDA has accepted this product, which is marketed under the name “Plenity”. … [Read More...]

  • Male Fertility Could Be Improved Naturally

    Male Fertility Could Be Improved Naturally

    A review article of CNN reviewed how male fertility could be improved naturally. Studies have shown that males contribute about 40 to 50% of the responsibility of any fertility problem of the couple. This means that a couple with infertility issues will benefit from interventions that include the male partner. Dr. … [Read More...]

    Jun
    15
    2019

    Replacing Part Of Red Meat With Fish Shows Health Benefits

    A Danish study has shown that replacing part of red meat with fish shows health benefits.

    The research was done by a PhD student and pointed out that men above the age of 50 were particularly benefitting from fish substituting part of red meat in their diet. Women in the childbearing age also benefitted greatly. On this diet pregnant women as well as the unborn children become healthier.

    Risk versus benefit analysis

    Sofie Theresa Thomsen, the PhD student who conducted this study did risk-benefit assessments regarding partial substitution of beef with low-mercury fish. Red and processed meat contains saturated fat, which is added to the other saturated fat in the Danish diet. Red meat and processed meats have been associated with colorectal cancer and some other cancers. But red meat also contains beneficial iron. In contrast, fish contains a lot of omega-3 fatty acids that are anti-inflammatory and also contains vitamin D. But one has to be careful about methylmercury content in fish. I reviewed fish, mercury contamination and the benefits in this link.

    In her calculations Sofie Theresa Thomsen replaced 350 grams of beef per week with 350 grams of low-mercury fish per week.

    If all the Danish households would do this partial beef/fish exchange, the Danes would gain 7,000 healthy years of life annually. This includes, among other health conditions, the prevention of 170 deaths from coronary heart disease.

    What kind of fish can you eat?

    As the link above shows, there are low, medium and high methylmercury contaminated fish. The higher the fish is in the predator chain, the higher the methylmercury content. This is of particular concern for pregnant women as mercury is toxic for the fetal brain tissue. But they consume low mercury fish and shellfish, like mackerel, herring, wild salmon, shrimps or clams, pregnant women benefit greatly from the beef/fish exchange. Tuna is too high in methylmercury to be included in the beef/fish exchange. If you were to include tuna in this, you would experience a health loss.

    Vitamin D and iron

    The study showed further that a partial exchange of beef by fish would reduce the number of Danes who are vitamin D deficient. The 350 grams of fish per week are sufficient to significantly raise the vitamin D blood level. Conversely, replacing a part of the beef intake with fish does not cause iron deficiency problems.

    Who benefits most from replacing part of red meat by fish?

    Sofie Theresa Thomsen asked who would benefit most from such a beef/fish exchange diet.

    On the one hand it is the older than 50 year male population who is at a significant risk of developing heart attacks. The fatty fish with omega-3 fatty acids reverses some of the plaque in the arteries and keeps coronary arteries open. This prevents heart attacks and strokes.

    On the other hand pregnant women and their children benefit greatly from the beef/fish exchange diet. The women will feel more energy and their offspring will have healthy brains.

    Replacing Part Of Red Meat With Fish Shows Health Benefits

    Replacing Part Of Red Meat With Fish Shows Health Benefits

    Conclusion

    A study from Denmark analyzed what happens when a person exchanges 350 grams of beef with low mercury fish or shellfish per week. The conclusion was that Danes would gain 7,000 healthy years of life annually. Among these is the prevention of 170 deaths from coronary heart disease. But the most lives saved would be among men older than 50 years due to heart attack and stroke prevention. Pregnant women are also benefitting tremendously, not only for themselves, but for their children. The fish needs to be low mercury fish, as mentioned above, as mercury is a central nervous system toxin. Tuna is too high in mercury.

    I have cut out red meat and meat products from my diet since 2015, when the WHO came out with the statement that red meat causes colorectal cancer. As a result I eat a lot more low mercury seafood and shellfish.

    Jun
    08
    2019

    How Can We Prolong Our Lives?

    The question “How can we prolong our lives?” is something that fascinates many people. It is not one thing, one activity, one diet, or one lifestyle factor that determines longevity. It is the combination of all of the things listed below that are necessary.

    Longevity is partially inherited from your mother

    The reason for this is that mitochondria in your body cells come from your mother’s body. As you know, the egg (ovum) contains the mitochondria (the energy packages of the cell). The sperm that is the winner penetrating the ovum is shedding the tail outside the ovum. The tail of the sperm had loads of mitochondria in it to give it the energy to wiggle its way up the Fallopian tube to meet the ovum. This is the reason why we all inherit our mitochondria from our mother. If there is longevity on your mother’s side, you likely will have the longevity gene as well. So, this certainly helps, but on the other hand, we cannot pick our ancestors! Don’t be discouraged! There is enough that you can do.

    Diet

    The best type of diet is a Mediterranean-type diet. There is a new fasting mimicking diet, that likely turns on latent longevity genes that need to be intermittently activated, if we are serious about wanting to increase longevity. Dr. Longo is the inventor of the fasting mimicking diet. I have discussed this in detail here. Briefly, it consists of eating 500 to 600 calories on 5 consecutive days. The rest of the month you eat normally. The important part is that Dr. Longo has shown in humans that telomeres get elongated by the 5-day protocol per month. Longer telomeres means longer life. This is what we want, because this adds life to our life expectancy!

    Lifestyle

    Don’t smoke and don’t do drugs. Drugs interfere with our hormone- and other cell surface receptors. Our body cells don’t like artificial chemicals from outside. Don’t overlook the fact, that alcohol is also a drug! Alcohol is a nerve and cell poison. It has been shown to even be toxic, so don’t drink all the time. If you want a drink here and there, you probably get away with it. But binge drinkers (6 drinks or more in one evening) are out of luck; their life expectancy is shorter than that of non-drinkers.

    Exercise

    Regular exercise recharges your mitochondria to give you extra energy. It conditions your heart and lungs and also your muscles. Many people think exercise would cause weight loss. But it is not leading to that much weight loss at all! What is more important is the fact that it is reducing the overall mortality from many diseases by up to 47%! Exercise also improves blood sugar control, energy levels and sleep patterns. There are also hidden benefits, as the heart is being conditioned and the lungs are improving their vital capacity from regular exercise, particularly aerobic exercises like running or using a treadmill. But muscle strength also benefits from regular exercise.

    Get enough sleep

    You need 7 to 8 hours of sleep, and it is best to go to sleep between 10 or 11 pm. During your sleep your brain is being renewed and your hormones are reloaded. There is a diurnal hormone rhythm that ensures you have enough energy for the following day. A Swedish study found that white-collar shift workers had a 260% higher mortality compared to a control group of daytime white collar workers: Shift work and mortality.

    Vitamins and supplements

    Some minimum vitamin and mineral supplements are helpful for longevity: Mornings: 2 capsules of molecularly distilled fish oil (omega-3 fatty acids). Two tablets of vitamin C 500 mg chewable, one capsule of 150mg of chelated magnesium, resveratrol 500mg, vitamin B complex B-50, zinc 30mg, vitamin K2 two capsules of 100 micrograms, vitamin D3 5000IU every morning, CoQ-10 400mg. Evenings: 2 capsules of molecularly distilled fish oil (omega-3 fatty acids). Vitamin B complex B-50, chelated magnesium 150mg, melatonin 3mg to fall asleep, valerian root 500mg capsule (if you have anxious thoughts); you may repeat melatonin and valerian root in the middle of the night, if you wake up at 2AM or 3AM in the morning.

    Brief explanation for vitamin and mineral replacement

    In case you wonder about the rationale of my suggestion for vitamin and mineral replacement, here is a brief explanation: vitamin C stimulates the adrenal glands and helps support the immune system. You get more energy and get fewer infections. Molecularly distilled fish oil is anti-inflammatory, helps prevent osteoporosis, but also prevents heart attacks by preventing inflammation of the arteries. Magnesium and zinc are co-factors in hundreds of biochemical reactions inside our cells, so this helps your metabolism.

    Resveratrol an anti-aging supplement

    Resveratrol is a bioflavonoid derived from red grapes. It has multiple beneficial effects. It lowers blood pressure, helps to control diabetes better and prevents osteoporosis. But resveratrol also elongates telomeres, which translated into a longer life and less diseases. B complex vitamins are good for energy and many metabolic processes. Vitamin K2 and vitamin D3 work together to get calcium out of our arteries and deposit calcium into our bones. This prevents osteoporosis, which is particularly important for postmenopausal women, but is also important for men. Resveratrol also prevents heart attacks and strokes. CoQ-10 is important to lower cholesterol, but also supports the metabolism of mitochondria, the energy packages of our cells.

    Hormone deficiencies

    We all know that there is menopause for women and andropause for men. But there are silent hormone deficiencies that are less well known. For instance melatonin secretion gets reduced fairly quickly after the age of 20. Between the age of 50 and 60 you are basically deficient for melatonin, so using a supplement of melatonin tablets would be very reasonable. Another hormone, namely human growth hormone (HGH) is very likely deficient in us by the time we are 50 to 60 years old. I will deal with this further below.

    Menopause

    Women get into menopause between 45 and 55, but they can get there earlier or later. Women are missing estrogen and progesterone. Many women were horrified by the Women’s Health Initiative result in 2002. But this trial involved synthetic hormones that the body did not like. So women got breast cancer, colon cancer, heart attacks and strokes from Premarin and Provera, both synthetic hormones. Had physicians been sensible and put them on bioidentical hormones instead, they would have prevented heart attacks, strokes and osteoporosis. They would also have prevented breast cancer and colon cancer. The proper way to replace missing hormones in women with menopause is to replace them with bioidentical progesterone cream and bioidentical estrogen cream.

    Andropause

    Men get into andropause between 55 and 65. The testicles will no longer provide the man with enough testosterone. This leads to lack of sex drive, erectile dysfunction, but also to more heart attacks, muscle weakness and a lack of energy. The problem is that there is not enough testosterone to stimulate the mitochondria. Mitochondria are very prominent in the heart muscle, skeletal muscles, but also in the brain. When the doctor confirms a lack of testosterone with blood tests, he orders replacement with bioidentical testosterone cream or by a simple testosterone injection twice per week. The man will feel better after a short period of time (4 to 6 weeks) as all his functions return back to normal.

    Many speakers at anti-aging conferences, which I attend every December in Las Vegas, seem to agree that bioidentical hormone replacement adds 10 to 15 years of life both in men and women. It also gives people renewed energy, and they look younger.

    Human growth hormone

    Many people do not know that human growth hormone (HGH) is important for longevity in adults. In childhood it was important for bone growth. Growth hormone deficiency is the one factor that has been underestimated. The discussion of dwarfs in comparison to their healthy brothers and sisters showed us the following. Growth hormone production can add between 19 and 34 years (average 26.5 years) of life. Dr. Hertoghe, an endocrinologist from Belgium has done blood tests (IGF-1) and lately also 24-hour urine metabolite tests of growth hormone on aging patients and found that many were deficient with regard to HGH production. These were patients where Dr. Hertoghe already replaced their thyroid hormones, if abnormal and replaced their sex hormones when they were low.

    Symptoms of human growth hormone deficiency

    But they lost hair, developed old looking faces with wrinkles. In addition, a loss of subcutaneous fatty tissue is giving the face a hollow appearance. They also had muscle and joint pains and thin skin, particularly over the back of their hands.

    Replacement of growth hormone

    He replaced their missing HGH using daily HGH self-injection with a tiny needle (similar to diabetes injections). Within 1.5 to 3 years the wrinkles disappeared, the faces started to look younger and patients did feel younger. Their muscle and joint pains had disappeared and their hair grew back. The dosage range is between 0.1mg and 0.3mg, a tiny amount of HGH daily. This is not inexpensive, but some health care plans pay for this, as a lack of HGH is a true hormone deficiency.

    How Can We Prolong Our Lives?

    How Can We Prolong Our Lives?

    Conclusion

    I have given you an overview of the important elements of what increases longevity. The key is to have a healthy, balanced diet and leave junk food out. Don’t smoke and don’t drink excessive amounts of alcohol. No alcohol consumption would be best, because alcohol essentially is a nerve poison and can lead to dementia. Exercise regularly to lower mortality and strengthen your heart and lungs. Get enough rest and sleep to refresh your diurnal hormone rhythm. When we age, it is important to keep an eye on our hormones. You need a physician who is knowledgeable about it.

    Hormone replacement

    Hormones that are missing need to be replaced by bioidentical hormones. In addition you need to know what the level of IGF-1 is. HGH controls the IGF-1 level. If IGF-1 is low, you need HGH replacement. Studies have shown that replacement of missing HGH may be able to add 2 decades of good life. All of the other hormones replaced by bioidentical hormones will add 10 to 15 years. As stated in the beginning, there is not one thing only that increases longevity, but a combination of all these factors.

    First published here: https://www.quora.com/What-increases-longevity/answer/Ray-Schilling

    Jun
    01
    2019

    More Obesity In Rural Areas

    A new study was published May 2019 in the magazine Nature showing that there is now more obesity in rural areas. In the mid 1980’s when the first reports came out about obesity, this was not the case. It actually was the opposite: there were more cases of obesity in cities compared to rural areas. The study was also reviewed in Medical News Today.

    The new worldwide obesity study was done by the Imperial College London in the United Kingdom. Researchers studied 112 million adults. The study population came from 200 countries and territories. The study covered 32 years from 1985 to 2017. More than 1000 scientists conducted this study worldwide.

    Findings of the obesity study

    Circumstances changed regarding obesity since the 1980’s

    The previous finding in the mid 1980’s that the urban population was leading the obesity wave was now reversed. There is now more obesity in rural areas while the urban population is eating more balanced meals. The population in rural areas of low- and middle-income countries are now accounting for 80% of the word obesity.

    Objective increase of BMI over 32 years

    The degree of being overweight or obese is best determined by the body mass index. This is the person’s weight in kilograms, divided by the height in meters, but squared. On this scale a normal BMI is 20.0 to 25.0, being overweight is from 25.1 to 29.9 and obesity is 30.0 or higher.  Women’s BMI has increased by 2.0 kilograms per square meter (kg/m2), while the men’s BMI has risen by 2.2 kg/m2 for both sexes over the study period. In rural areas the BMI has risen by 2.1 kg/m2 while in urban areas, the average BMI of women rose by 1.3 kg/m2 and for men by 1.6 kg/m2.

    Healthier lifestyle in cities compared to rural areas

    The BMI in high-income countries has grown particularly in rural areas. Prof. Ezzati commented to this: “In fact, cities provide a wealth of opportunities for better nutrition, more physical exercise and recreation, and overall improved health.”

    More obese women in urban centers of sub-Saharan Africa

    In sub-Saharan Africa there is an opposite trend compared to other countries. In Africa the women in urban centers are getting obese while their counterparts in rural Africa have less problems with obesity. The researchers thought that this is due to city women moving less and sitting at desks etc. In contrast women in the rural areas of sub-Saharan Africa are doing more physically demanding tasks.

    What are the issues about obesity?

    The problem is that people who turn obese eat the wrong foods. The problem is often that they eat too much sugar and too many starchy foods. Here is my remedy to prevent obesity.
    1. Cut out sugar. Cut out highly refined starches. This prevents diabetes, heart attacks and strokes.
    2. Avoid red meat and processed meats: this reduces the risk of colorectal cancer.
    3. Eat clean foods: organic vegetables or your own vegetables grown in your garden; organic salad; grass-fed beef once per week (not more often); organic chicken and turkey; bison meat once every week or every two weeks; wild salmon two to three times per week.
    4. If you exercise regularly on top of eating healthy foods, you can drastically reduce many illnesses and diseases compared to those who don’t.

    Remove the majority of starchy foods from your diet

    I wrote about avoidance of highly refined starches. I cut out starchy foods as they digested into sugar and give you an insulin response causing hyperinsulinism, inflammation in your arteries, strokes, heart attacks and Alzheimer’s. If you can do it and you don’t want those diseases: cut out wheat and wheat products especially white flour; pasta, bread, baked good. Potatoes, white rice and refined cereal are also problematical. I have avoided this since 2001 and lost 50 pounds. I kept my weight down since. My body mass index is between 21 and 22. I have energy, work out, and I don’t miss these items. Re-evaluate your food habits, and next clean out your pantry!

    More Obesity In Rural Areas

    More Obesity In Rural Areas

    Conclusion

    An international study examined the rate of obesity in 200 countries, involving 112 million people over a long time span, namely over 32 years. While in the mid 1980’s most obese patients lived in big cities around the world, this pattern has changed. Now there is more obesity in rural areas. People in the cities are learning more about healthy nutrition and they have more access to fitness centers. In order to tackle the obesity problem people must learn the difference between nutritious food and junk food. You need to cut out sugar as much as possible. It is the biggest offender and contributes to a list of health problems. But you need to remove processed food from your diet, because it contains sugar and unhealthy fats. Red meat and processed meats are also unhealthy and should be removed.

    What to eat

    Eat clean foods such as organic vegetables or your own vegetables grown in your garden. Buy at farmers’ markets, if they are in your area. Consume organic greens. If you cannot live without red meat, limit your consumption to grass-fed beef once per week (not more often); organic chicken and turkey; bison meat once every week or every two weeks, and enjoy wild salmon two to three times per week. It is easier to do than you think, prevents obesity and keeps you healthy until a ripe old age.

    May
    26
    2019

    The Foods That Are Killing Us

    There is an article in a CNN report talking about the foods that are killing us. This review is based on an article in the Lancet. The Lancet study was based on a global review of eating habits in 195 countries. The question in the study was which of 15 food items caused the diseases that killed people. The answer was surprising. There are either omissions or unhealthy components of foods that kill us. Here is a list of 12 food groups that are problematical.

    A dozen foods that were found to be problematical in the global review

    • Diet high in sodium (4 grams per day, which is 86% above the optimal level)
    • Low intake of whole grains (only 23% of optimal levels)
    • Low fruit intake
    • Diet high in trans fatty acids
    • Low omega-3 fatty acid diet (due to low intake of sea food)
    • Diet low in calcium
    • Diet low in fiber
    • High intake of sugar beverages or sugary foods (49 grams of sugar per day)
    • Processed meat intake too high (4 grams per day, 90% more than optimal)
    • Red meat consumption too high (27 grams per day, 18% higher than optimal)
    • Nut and seed intake too low (only consuming 12% of desired amount)
    • Diet low in milk (16% of desired amount)

    Each of these components or several of them in combination create deficiencies in us or overburden us to the point where we can get sick and disabled.

    Different countries have different eating habits

    Globally there were 11 million deaths found in 2017 and 255 million years of disability because of various dietary inadequacies.

    Here is the lineup of the leading causes of death:

    • cardiovascular disease with 10 million deaths and 207 million years of disability.
    • Cancers caused 913,090 deaths and 20 million years of disability.
    • Type 2 diabetes caused 338,714 deaths and 24 million years of disability.

    This was broken down into statistics for each of the contributory countries. Here I am only citing some pertinent data that shows the importance of balanced meals for a healthy life expectancy.

    Different death rates in various countries

    There were big differences in terms of cardiovascular disease deaths according to various regions. Central Asia had the highest death rate with 613 deaths per 100,000 people per year. In contrast the high-income Asia Pacific group had only a cardiovascular death rate of 68 per 100,000 people per year.

    Cancer deaths were highest in East Asia with 41 deaths per 100,000 people. The lowest cancer rate was found in North Africa and the Middle East with 9 deaths per 100,000 people.

    Among the 20 most populous countries Egypt had the highest diet-related deaths, namely 552 deaths per 100,000 people. On the other hand Japan had the lowest of all diet related deaths with 97 deaths per 100,000 people. 

    Some highlights how unhealthy foods kill us

    Globally people only eat 12% of the desirable amount of nuts and seeds. They only drink 13% of what they should consume in terms of milk. People worldwide eat 23% of the desirable amount of whole grains.

    Nuts and seeds contain mono- and polyunsaturated fats and omega-3 fatty acids, which lower your risk of getting heart attacks and strokes.

    Milk is a good source of calcium, protein, minerals and vitamins. However, milk, yogurt or cheese should be consumed as low fat varieties. Alternatively people who do not consume milk should look for protein carriers such as soy milk or pea milk.

    If you eat nuts and vegetables you can largely compensate for low milk consumption. If you don’t get enough whole grains, you are missing a whole lot of nutrients. This makes you more vulnerable of getting cardiovascular disease, hypertension, type 2 diabetes, colon cancer, and obesity.

    Other unhealthy foods can kill us

    The WHO has labelled red meat and processed meat as being carcinogenic

    Studies clearly showed a higher than normal rate of colorectal cancer in those who consumed larger amounts of red meat and/or sausages.

    Sugar overconsumption

    Sugar overconsumption leads to a variety of conditions. Weight gain with the development of obesity and type 2 diabetes are common when you eat too much sugar. But even cancer like colorectal cancer and pancreatic cancer is more common in people who overindulge in sugar or sugary drinks. Sugar consumption raises your triglyceride and LDL level. This will eventually lead to hardening of the arteries, heart attacks and strokes.

    Gout develops with purine containing foods

    Gout can be caused by consuming a lot of red meat combined with copious amounts of beer. This is how royalty in the Middle Ages suffered from gout attacks. Gout had the nickname of “Disease of the affluent.” Both beer and red meat contain a lot of purines, which the kidneys cannot handle. The uric acid crystals that precipitate around joints cause excruciating pains.

     What the global health study showed

    Researchers of the global health study stated that improving the diet habits could potentially eliminate 1 in 5 deaths globally. Dietary risks for major diseases like heart attacks, strokes and cancer are independent from sex, age and socioeconomic status.

    Three dietary factors stood out: too much salt, too little fruit and too little whole grain. These three items were responsible for 50% of diet-related deaths and 66% of “disability-adjusted life years”. The authors used this expression to describe how years of disability had their root in diet deficits (e.g. too little fruit) or overdoses of unhealthy food components (e.g. salt).

    The leading dietary risk factors are too much salt, low whole grain, low fruit consumption, low vegetable intake and low omega-3 fatty acid consumption. On top of that come the previously established risks due to sugar overconsumption, excessive fat intake and consumption of red meat and processed meat.

    Discussion of the meaning of these results

    Deaths from heart attacks and strokes

    We know for some time that high sugar and high starchy food intake cause elevated triglycerides and elevated LDL cholesterol. This leads to hardening of the arteries and eventually to strokes and heart attacks.

    High sodium intake

    Sodium intake of more than 2300 mg per day is considered high and can cause high blood pressure. heart attacks, strokes and aneurysms.

    Eating not enough fruit

    If you eat too little fruit, your system does not get enough vitamin C and other vitamins. Heart disease, cancer and anemia could develop from that.

    Eating not enough vegetables

    People who do not eat enough vegetables do not have enough antioxidants that protect them from free radicals. Free radicals are unstable chemicals that attack cells and DNA. Mutated cells can cause cancer. If you eat too little vegetables, you are at a higher risk of getting cancer. But there is another aspect of vegetables: phytonutrients protect from hardening of the arteries and blockages of heart and brain vessels. When someone does not eat enough vegetables, the risk for heart attacks and strokes is higher. Eating vegetables also protects you from diabetes and keeps the blood sugar more stable.

    Not eating enough whole grain

    Whole grain was identified as missing in a lot of people’s diet. When you incorporate whole grains into your food, you reduce the risk of cardiovascular disease, hypertension, type 2 diabetes, colon cancer, and obesity.

    There are vitamins, minerals, dietary fiber and lignans in whole grain. Other nutrients are beta-glucan, several phytochemicals, phytosterols, phytin, and sphingolipids. All of these are necessary to maintain good health.

    Low omega-3 fatty acid consumption

    Omega-3 fatty acids are important for healthy skin, brain development (neurodevelopment of children) and prevention of heart attacks. Omega-3 fatty acids reduce the risk of cancer because of their anti-inflammatory action and inhibition of cell growth factors. In one study rectal cancer showed a 21% reduction comparing the highest omega-3 fatty acid intake to the lowest intake of omega-3 fatty acids. Colon cancer showed no effect to omega-3 consumption, but breast cancer showed a reduction with omega-3 fatty acid supplementation. Researchers showed that omega-3 fatty acid supplementation can slow down dementia and Alzheimer’s disease. Protein deposits called amyloids were found less in the brain of patients with omega-3 fatty acid supplementation; in addition the brain volume was preserved more with the omega-3 supplement. Low omega-3 fatty acid consumption also has a detrimental effect on macular degeneration of the eyes and on joint pains of rheumatoid arthritis patients.

    The Foods That Are Killing Us

    The Foods That Are Killing Us

    Conclusion

    I have reviewed a global health study that described various risks that led to deaths from different diseases. It was noticeable that death and disability rates varied significantly according to different countries. The authors also looked into food habits and could pinpoint certain food deficiencies that caused diseases that prematurely disabled or killed people. I have described the various one-sided food habits that led to specific diseases.

    What we should all learn from this complicated study is that we all can strive to eat more balanced meals. You want to eat a low sodium diet, eat enough fruit and vegetables, to which you add some nuts. Eat enough whole grains and add omega-3 fatty acids. This way the risk of getting cancer, cardiovascular diseases or other problems can be significantly reduced.

    May
    18
    2019

    A Pill Against Obesity

    At the 26th European Congress on Obesity in Glasgow, Scotland a pill against obesity was introduced. Here is a report about this on CNN. The biotechnology company, Gelesis had funded the research. This company also developed the product. The FDA has accepted this product, which is marketed under the name “Plenity”. The FDA gave clearance for Plenity as a prescription weight loss product for use in overweight adults with a body mass index above 25.0. Genesis has announced that Plenity will be available in the US by 2020. The cost of it is yet unknown.

    How Plenity, a pill against obesity, works

    Plenity actually is a medical device. It is a capsule that contains tiny little gel pieces that dissolve in the stomach. Patients take one capsule with water before lunch and dinner. When the gel pieces swell it gives a fullness feeling that limits calorie intake. The hydrogel pieces increase the volume of the stomach and small intestine. By the time the gel particles arrive in the large intestine, enzymes have partially broken down the hydrogel, water is released and the rest is expelled in the feces. Dr. Ken Fujioka, a weight loss expert, endocrinology researcher at Scripps Clinic and scientific advisor to Gelesis said: ”The most compelling aspects of this approach are its effectiveness, novel mechanism of action and impressive safety data. This approach creates another arm in the treatment algorithm of weight management and could be used by an overwhelming majority of people struggling with weight issues”.

    Randomized placebo controlled weight loss study with Plenity

    Gelesis sponsored a weight loss study with 223 patients in the experimental group and 213 in the placebo group. The length of the weight loss study was 171 days. The placebo group lost 4.39% body weight, while the group on Plenity lost 6.41%. There were very few side effects, like an abdominal fullness or bloating.

    Discussion regarding Plenity, a pill against obesity

    Along with taking Plenity the investigators asked the patients to also stay physically active and adhere to a sensible diet. I know from my own experience that a change in diet can make you shed significant weight and you can keep it down. In 2001 I lost 22.7 kg (=50 pounds) over 3 months, down from 85.5 kg. I weigh now 62.8 kg. With this data you can calculate that I lost 22.7/85.5=26.5% of my original weight. I did so in 90 days, not in 171. It was the difference in food intake that enabled me to lose this weight. I had cut out all sugar, starchy foods, processed food and wheat.

    The pill will help patients feel full after smaller helpings, instead of having hunger pangs, and this can be valuable and will contribute to being successful with losing weight. But long-term weight control only works with an adjustment of dietary habits and lifestyle choices. 

    Keeping weight loss in perspective

    The authors stated that their best patients were losing 5% and 10% when they watched their diet and exercised. When I compare my own data (26.5% weight loss) and theirs I conclude that they did not try hard enough. And they did not have to rely on any diet pills. It is clear from the data that the placebo group had significant weight loss with just watching their diet and exercising. I do acknowledge that Plenity has a slightly better effect. However, when people complete with their weight loss program, they will continue to eat their former diet regimen. This will make them gain everything back what they have lost.

    For 18 years I have not gained back what I lost in 2001 because I have stayed on the same diet that some people may label as “radical”. There is nothing wrong with vegetables, salads, lean poultry, fish, nuts, fruit etc. I suspect that people could easily lose 10% to 20% of weight without any weight loss pills, if they took a similar approach as I did.

    A Pill Against Obesity

    A Pill Against Obesity

    Conclusion

    Weight loss seems to be a topic that is of interest to many people. There is the expectation that the new weight loss pill Plenity will be the solution to people’s diet problems. However, the difference in weight loss between the placebo group and the experimental group was only 2.02%! It took the researchers 171 days to be able to say that there was a significant difference between the Plenity group and the placebo group.

    Cutting out junk foods

    When I did my own weight loss program based on dietary changes alone I had lost 26.5% in only 90 days. I suggest that people should not forget to change their food intake, cutting out junk food and adopting a healthy food intake. They may not require Plenity pills at all or for a much shorter time. Preparations for the time after the weight loss achievement are necessary or else there will be rebound weight gain. Long-term success is only possible with sensible dietary choices and lifestyle choices, such as regular physical activity.

    May
    11
    2019

    Male Fertility Could Be Improved Naturally

    A review article of CNN reviewed how male fertility could be improved naturally. Studies have shown that males contribute about 40 to 50% of the responsibility of any fertility problem of the couple. This means that a couple with infertility issues will benefit from interventions that include the male partner. Dr. Natan Bar-Chama is the director of the Center of Male Reproductive Health in New York. He is a board-certified urologist and male infertility specialist. Dr. Bar-Chama has done research into what affects male fertility. He found that there are several factors that are important for male fertility.

    Lifestyle factors

    The big factors that interfere with fertility are obesity, caffeine and alcohol intake, smoking, marijuana intake, lack of exercise and wearing too tight underwear resulting in increased scrotal temperature.

    Obesity

    Overconsumption of refined carbs like sugar and processed foods leads to obesity. The best for him is to change his diet to a Mediterranean diet. This supports weight loss and at the same time improves sperm quality.

    Obese men tend to father children that often are not viable. It may be that it is due to genetic changes in the sperm in obese men. These changes can affect fertilization, but also embryo development. Researchers have detected sperm DNA fragmentation in sperm from obese men, which can lead to pregnancy loss. Weight loss in obese men improves sperm quality.

    Caffeine and alcohol intake

    More than 1 or 2 cups of coffee a day relates directly to difficulties for a couple to conceive. When it comes to alcohol intake, the male should not drink more than one glass of wine or the equivalent of alcohol in beer or spirits per day. Higher consumption results in male infertility due to poor sperm quality. Physicians have warned women for a long time that they should stop drinking alcoholic beverages, if they want to become pregnant. It is best, if both partners don’t drink for the sake of a healthy pregnancy.

    Smoking

    Stop tobacco and drug use. Smoking and drug abuse have been consistently shown to be bad for sperm quality and are associated with infertility. Marijuana use leads to low sperm counts, which is a cause of infertility.

    Lack of exercise

    Moderate aerobic exercise and resistance exercise can improve sperm quality.

    However, excessive exercise has shown negative effects on sperm. Bicycling for 5 hours or more has been shown to reduce sperm quality due to the heating up of the scrotum and the testicular tissue. For the same reason men wearing boxer shorts instead of tight underpants were observed to have higher sperm concentration and sperm counts.

    Antioxidants

    Oxidative stress can damage sperm. This involves smoking, a junk food diet, obesity, pollution, radiation and heavy metals like mercury from big game fish (like tuna, shark, sable fish, sword fish etc.). Dr. Bar-Chama said: ”When you cause damage to cell membranes, you are impacting the ability of the sperm to attach, penetrate and activate the complex fertilization process”. In order to counter these negative effects of the environment it is helpful to take antioxidants.

    Some of the common antioxidants are: vitamin C and E, beta-carotene, selenium, zinc, folic acid, lycopene and coenzyme Q-10. If you get 5 servings of fruit and vegetables, you get most of the antioxidant vitamins and minerals. You find selenium in Brazil nuts, sardines and halibut. Oysters, dark-meat poultry, crab, and fortified cereals contain zinc, which supports male fertility.

    Omega-3 fatty acids

    Omega-3 fatty acids from fish and seafood has been shown to increase the success rate of couples who want to get pregnant. Low mercury seafood like scallops, clams, shrimp, oyster, sardines, salmon and squid are a good source of omega-3 fatty acid.

    Get some nuts

    A handful of nuts or two also helps the male to produce more healthy sperm. This study showed that nut consumption improved the total sperm count. In addition, it increased vitality, motility, and morphology of the sperm.

    Cut out processed meats

    Another study showed that consumption of processed meat had a negative association with fertility rates in couples that desired children. However, eating chicken instead of processed meat gave the fertility rates a boost.

     

    Male Fertility Could Be Improved Naturally

    Male Fertility Could Be Improved Naturally

    Conclusion

    We have been lulled into thinking that when there are fertility problems in a marriage, it would likely be due to female reproductive problems. This kind of thinking is old school and has been disqualified by newer research. It turns out that often the problem originates from the man, if he is unwilling to change his lifestyle to get ready to father a child. As outlined above there are quite a few factors that interfere with sperm production and motility of the sperm. If he wants to father a child, he needs to take good care of his sperm by adopting healthy lifestyles. Sperm, it turns out are much more vulnerable to toxic changes, heat from tight clothing, and nutritional deficiencies.

    Healthy food for the man results in a healthy child

    Not everything is exclusively the responsibility of the female. The male also needs to eat balanced meals and might also benefit from some antioxidants and supplements. Omega-3 fatty acids from nuts and seafood are also good for sperm production and motility. Add some moderate physical exercise, and he will be ready to father a child. It is very much a team effort, as both parents- to- be have to do their part and embrace a healthy lifestyle.

    May
    04
    2019

    You Need Consistency With Exercise

    In order to exercise regularly, you need consistency with exercise. Many of us have made a New Year’s exercise resolution, but later gave up, because we decided to have other priorities.

    A new publication examined why we often fail maintaining a regular exercise pattern. It was reviewed by CNN in this article:

    Often with New Year’s come the resolution to exercise regularly. It seems to be the result of overdoing things during the holidays: too many parties, too many drinks, too much turkey dinner. But within a few weeks only 46% are only continuing to exercise, 54% stop doing it. Within the adult population in the United States 80% are not getting the minimum weekly 150 minutes of moderate-to-vigorous exercise that they would need for good health. This is what the World Health Organization is recommending.

    What can we do to belong to the successful minority that exercises regularly?

    Figure out why you want to exercise

    First of all, you need consistency with exercise and we need to be aware why regular exercise is important. Many people think exercise would cause weight loss. But it is not leading to that much weight loss at all! What is more important is the fact that it is reducing the overall mortality from many diseases by up to 47%! Exercise also improves blood sugar control, energy levels and sleep patterns. There are also hidden benefits as the heart is being conditioned and the lungs are improving their vital capacity from regular exercise, particularly aerobic exercises like running or using a treadmill. But muscle strength also benefits from regular exercise.

    Change your mindset

    Many people don’t consider themselves as “exercisers” and they lack the confidence of being able to exercise regularly. You need to re-program your mindset, but this may not be easy and you need consistency with exercise. You may want to set smaller goals that you can easily achieve. Over time you gradually increase your exercise goals. By actually doing some exercise regularly, you will overcome your temptations to quit exercising. Be flexible, as you may sometimes be faced with barriers to exercise as originally planned. Instead of going to the gym you may want to go for a brisk walk instead. As time goes on you will get regular exercise built into the routine of your day. Consider it as time for yourself and for your health.

    Building a better exercise pattern

    You want to build a strong pattern of exercising regularly. This way you do not have to decide whether or not you want to exercise today. When exercising is a habit, you simply do it out of habit. Simple cues like placing your exercise outfit somewhere prominently can help to remind you to exercise. There are other cues that can be useful, as a Canadian study showed.

    Elongation of telomeres with regular exercise

    Twin studies have shown that regular exercise elongates telomeres, the caps on chromosomes. Here is the explanation. This study showed that regular exercise can make your telomeres 9 years younger compared to a group that does not exercise regularly.

    You Need Consistency With Exercise

    You Need Consistency With Exercise

    Conclusion

    Exercising regularly brings tangible assets to your life in the form of improved cardiovascular fitness and up to 47% decreased mortality due to reducing the overall mortality from many diseases. You also feel more energetic, and other studies have shown that your telomeres get elongated. This translates into 9 years of longer life just because you exercise regularly! If you want more motivation, just stick a message on a wall, where you see it every day. “I’ll live 9 years longer.”

    Apr
    27
    2019

    Mayo Clinic Could Become A Health Care Model

    I watched the movie “Mayo Clinic: Faith-Hope-Science”, which suggested that the Mayo Clinic could become a health care model. The movie aired originally on Sept. 25, 2018. It is a fascinating presentation of the history of the Mayo Clinic.

    Historical facts

    The Mayo Clinic is well known for its surgeries. In the beginning there were only 3 surgeons, Dr. William Worrall Mayo and his two sons, Dr. Will and Dr. Charlie. In 1904 alone they performed more than 3000 surgeries at St. Mary’s Hospital. Today 255 Mayo Clinic surgeons do more than 76,000 surgical procedures for patients.

    The original Mayo Clinic was built in Rochester (Minnesota). Later two more Mayo Clinics were added, in Jacksonville (Florida) and Phoenix (Arizona). Here is a link that shows more historic facts.

    Involvement in Wars

    The Mayo Clinic provided medical care during WWI, WWII and during the Korean War. Management of the Mayo Clinic decided to erect portable clinics close to the battlefields. Treatments for the injured soldiers were free.

    Mayo Clinic Involved in Research

    From early on in the development of the Mayo Clinic research played an important part. Now there are three Mayo Clinics, each with their own research facilities. There is a campus of a Medical School connected with the Rochester Mayo Clinic. The Medical School puts emphasis on medical research.

    Organization of the Mayo Clinic

    The organization of the Mayo clinic was initially based on a handshake between the Sisters of Saint Francis who provided nursing skills and the medical staff that provided diagnoses, surgeries and investigations. The movie reported that the handshake philosophy lasted for over 100 years, but eventually the administration came up with a formalized agreement.

    A few peculiarities are worth noting.

    Doctors on salaries

    All doctors working for the Mayo Clinic are on salary. This is in stark contrast to the rest of the medical system in the US. The US medical system is a fee-for-service system. The problem is that fee-for-service clinics rush patients through their appointments. In the past one patient was seen on average every 15 minutes, then every 10 minutes, and now often there are only 7 minute time slots. The more patients a doctor sees in an hour, the more money he/she makes. With a complicated patient at the Mayo Clinic a doctor may take 2 yours to see such a patient. It makes no difference in term of salary to the doctor, but the quality of care and thoroughness of examining a patient can make a huge difference.

    Proton therapy made affordable

    When proton therapy was first introduced in the Mayo Clinic for cancer therapy, patients could not afford the higher costs of proton therapy versus conventional radio beam therapy. The Mayo Clinic resolved this problem simply by charging the same cost for both procedures. This way the doctor decided, which approach was more appropriate for a particular patient, but there was no financial hardship as a result of this decision.

    When poor people cannot afford health care

    Another peculiarity evolved when it became apparent that some very poor people could not afford the treatment. The nurses and the doctors consulted about this problem and decided that nobody should suffer diseases because of financial hardship. The minority of these patients received free treatments from the Mayo Clinic. To correct for the difference the administration was charging the well-to-do people a little bit more. Over the years the Mayo Clinic had made enough profit that they could expand and build bigger clinics. There are now three Mayo Clinics, namely in Arizona, Florida and Minnesota.

    Other health care jurisdictions

    I have worked in the Canadian health care system for 16 years as a general practitioner. Like in the US this is based on a fee-for-service system. Subsequently I worked as a Medical Advisor for the Workers’ Compensation Board of British Columbia (“WorkSafeBC”). This was a salaried position. The advantage of being in general practice is that you are in charge of your practice. You can decide how many hours in a day you work and how many patients you will see on average in an hour. Because of the fee-for-service remuneration from the government this determines your annual income. It also determines your income tax status, so that the take-home pay may not be that much larger than the take-home pay as a salaried physician.

    The system in Germany is similar. Most patients have coverage by the regular insurance company (AOK patients). But there is a two tier system, where private patients have insurance coverage by a private insurance carrier, called DKV. They experience a different treatment. Unlike the AOK patients (fee-for-service) there is no rush when the doctor examines a private patient. The doctor takes a lot more time to see a private patient and is more thorough with the examination. The remuneration for the private DKV patients is 3 to 4-times as much as for an AOK patient.

    Mayo Clinic could become a health care model for the US

    The Mayo Clinic has been in existence for 150 years. It has achieved the highest level of care in the US and many physicians refer their difficult to diagnose patients to this clinic. It seems that financially the clinic is also on solid grounds.

    Could this system be transferred to the US health care system at large? Several points have to be considered regarding this.

    Health care should be administered by each state separately

    Health care is administered by each of the separate states. But federally the United States Department of Health & Human Services (HHS), also known as the Health Department should be responsible for health care in the US. This means that there has to be consultation between the Federal and the state level.

    Biggest problem to convince all practicing physicians to be on salary

    The biggest problem would be to convince that all of the practicing physicians should be on salary. For centuries patients paid for physicians’ services by using a “fee for service” payment schedule. For physicians this is the gold standard. They perceive the payment for their services as independent from the government. They have a deep distrust whether the government will treat them fairly. Another complicating factor are very high liability insurance payments, and medical lawsuits are common. How can a physician afford sky-high insurance rates? It is only possible with an agreement that pays a fair salary to all physicians. This will stabilize the healthcare system.

    Escalating drug costs curtailed by generic drugs

    Regarding the escalating costs of brand name medicines a solution is to allow generic drugs. They are chemically identical to brand name drugs. They are often 1/3 or ½ the cost of brand name drugs. Many non-US countries have used generic drugs for many years with no problems. But in the US pharmaceutical companies that produce brand name drugs have maligned generic drugs. They call generic drugs to be inferior.

    Provisions need to be made to cover poorer people

    Provisions for poorer people allow them to not have to suffer from untreated illnesses. The Healthcare Plan can take care of this in a similar fashion as the Mayo Clinic did. The health care premiums to be paid by every citizen in the US would be dependent on what your annual income is. People in higher income groups would pay a slightly higher premium than low- income people or middle-income people. Special provisions would apply to cover healthcare costs for people in training who do not yet have an adequate income. But essentially everybody would pay something into the health care plan. This way there would be enough funding for the health care system.

    Will all the players accept that the Mayo Clinic could become a health care model?

    Whether or not the US public at large would ever accept this proposal, all of the physicians and all of the major players of the health care industry remains to be seen. It would contain the healthcare costs and would cover every US citizen for healthcare expenses.

    Mayo Clinic Could Become A Health Care Model

    Mayo Clinic Could Become A Health Care Model

    Conclusion

    The Mayo Clinic has provided 150 years of healthcare coverage and provided excellent medical service. There is no reason why this type of system would not work for the general public. Healthcare coverage would be provided for everyone, regardless of their income. The high-income group would pay more than the middle income and those with low incomes. But everybody would receive the same healthcare service. Physicians would be on salary. Drugs would be largely generic drugs, but would also be trademark drugs, if no generic drugs are yet available.

    100% enrolment ensures full funding of healthcare plan

    By having 100% enrolment into the healthcare plan there would be no shortage of funding as healthcare costs average out when everybody -young and old people, rich and poor -are all included. It would require negotiations of the United States Department of Health & Human Services (HHS), backed up by the president and including the health departments of all of the states in the US. The Mayo Clinic succeeded achieving all of this within the US. Why should the US at large not be able to copy that system in all of the states?

    Apr
    20
    2019

    Some Reasons For Variations In Cancer Rates

    It can be confusing to see that various countries have big differences in cancer rates, but here I am giving some reasons for variations in cancer rates.

    The following countries have high cancer rates: Denmark, France, Belgium, United States, Hungary, Ireland, New Zealand, Australia.

    These countries have low cancer rates: Niger, Yemen, Oman, Nepal, Mauritania, Gambia, Cape VerSe, Bhutan. These are only samples; it is not a complete list.

    Short life expectancy in many low cancer rate countries

    People in many low cancer rate countries do not live long lives because of parasitic infestations, bacterial infections and AIDS. Life expectancy in Gambia, for instance is only 61.15 years. People in Yemen suffer from malnutrition and the life expectancy is only 64.95 years. One can make an argument therefore that people do not live long enough to get a lot of cancer. Cancer is a disease of the older population, as DNA mutations, shorter telomeres, and loss of mitochondria in older cells cause many cancers.

    These three countries have various cancer rates

    Low cancer rates in India

    India is one of the countries with lower cancer rates when compared to the US. Scientists have pointed out that 40% of Indians are consuming vegetarian diets without meat; (red meat consumed in high amounts like in the US is carcinogenic). India has some of the highest spice consumption in the world. We know that curcumin, for instance, has cancer-preventing qualities. You could say that Indians inadvertently treat themselves with herbal, non-toxic chemotherapy (curcumin and others spices) before a cancer even occurs. On the other hand India is a nation with high consumption of refined sugar, which is a factor that can cause cancer over a long period of time. The life expectancy in India is only 68.56 years, which skews the statistics towards lower cancer rates when one compares India to countries with a life expectancy of 80.0 years.

    Why is Denmark a high cancer rate country?

    The biggest factors are a reliable cancer reporting system, but also a high smoking rate among Danish women and high alcohol consumption in the Danish population. See below what these factors do.

    Why is Oman a low cancer rate country?

    A study done in Oman showed that a lot of people do not know that certain risk factors could be changed to lower the present cancer incidence. Cigarette smoking, passive smoking, excessive alcohol consumption, reduced intake of fruit and vegetables, increased consumption of red meat and processed meats, infection with HPV, being overweight, less physical activity and an age above 70 are all risk factors for cancer. At the present time Oman still compares favorably with the US, as there is less obesity in Oman. But the average person still eats fairly healthy with an emphasis on fruit and vegetables.

    Increasing cancer rates in Oman

    The cigarette consumption per year per person in Oman is 271.1 versus 1016.6 in the US. The life expectancy has increased from 50.47 in 1970 to 77.03 in 2016. Oman is expecting the cancer rate to double by the year 2030 due to the increasing life expectancy and lifestyle factors (more drinking, smoking and gaining weight from junk food). A lot of the differences in the cancer rates between the US and Oman are simply due to lifestyle differences. 

    Cancer risk factors analyzed

    What do the various cancer risks mean in terms of cancer development?

    Cigarette smoking

    About 480,000 premature deaths are caused by cigarette smoking in the US. This is due to a combination of cancer, heart attacks and strokes. Smoking causes cancers of the lung, esophagus, larynx, mouth, throat, kidney, bladder, liver, pancreas, stomach, cervix, colon, rectum, but also acute myeloid leukemia.

    Passive smoking

    Passive smoking is as bad, if not worse than smoking. This reference explains that a passive smoker has double exposure to cigarette smoke, namely to the smoke from the smoker, but also to the direct smoke from the burning cigarette. This means that a passive smoker may have exposure to a higher concentration of carcinogens than the smoker!

    Excessive alcohol consumption

    Heavy alcohol consumption introduces a cell poison into your body. If you drink more than 8 drinks per week as a woman or more than 15 drinks per week as a man, you are a heavy drinker. It leads to cancer of the mouth, esophagus, throat, colon, liver, breast and prostate. The data on prostate cancer is somewhat weaker.

    Reduced intake of fruit and vegetables

    Consumption of fruits and vegetables, but also foods high in fibre are known to reduce the risk of cancer. This is why the WHO brought out this fact sheet. So, when you lower the intake of fruits and vegetables, you have less of a cancer protective effect, which leads to more cancer.

    Increased consumption of red meat and processed meats

    Another big factor about cancer causation is when you eat foods that contain known carcinogens. Such cancer causing substances are contained in red meat, processed meat like sausages, and salt-preserved foods.

    Infection with HPV

    Type 16 and 18 HPV virus is the cause of cervical cancer, penile cancer, oropharyngeal cancer, anal cancer, vulvar and vaginal cancer. It can be of concern for all sexually active people.

    Being overweight

    When a person gets overweight or obese, there is more estrogen production from the fat cells that circulate in your blood.  There is also more insulin production and IGF-1 production, which is a growth factor for cancer cells. Estrogen dominance due to estrogen production from fat cells with a relative lack of cancer-controlling progesterone tips the balance towards cancer development. These are the cancers that are common in obesity: breast (in women past menopause), colon and rectum, endometrium (lining of the uterus), esophagus, kidneys and pancreas.

    Less physical activity

    Breast cancer and colon cancer are reduced when people exercise regularly. This seems to be because of a reduction in circulating estrogen in women and because of reduced insulin and insulin-like growth factors. Even prostate cancer can be kept at bay with a regular brisk walk.

    An age above 70

    The medium age for cancer diagnosis is 66 years. This means that half of the cases are below this age, the other half above it.  25% of new cancer cases are diagnosed in the age group of 65 to 74. Age is an independent, but important risk factor for the development of cancer.

    Sugar and starchy food consumption

    Refined sugar and starchy foods lead to an accumulation of fat. At the same time there is a metabolic change with more insulin production and growth factors appear in the blood. It is these growth factors and an increase in estrogen (via aromatase) from the fat cells that lead to conditions that favor cancer development. Switch to a low-glycemic diet like a Mediterranean diet, and you can reverse this process.

    Some Reasons For Variations In Cancer Rates

    Some Reasons For Variations In Cancer Rates

    Conclusion

    It is never too late to reduce your cancer risk. No matter how old we are, it is never too late to live healthier, which translates into a stronger immune system. We can stop smoking, or cut out drinking too much. If we keep a healthy weight and eat a healthy diet we will stop chronic inflammation in our bodies and strengthen our immune system. We need to stay away from ultraviolet light (direct sun exposure). We also need to stay active, no matter whether it is choosing to take the stairs and take daily walks, or whether we exercise regularly in a gym.

    Apr
    13
    2019

    New Alzheimer’s Genes

    A recent genetic study summarized in a CNN article describes the detection of new Alzheimer’s genes. First of all, it appears that Alzheimer’s genes and trigger factors have to interact to cause Alzheimer’s disease. Secondly, in a 2013 study the International Genomics of Alzheimer’s Project had examined a population of 75,000 Alzheimer’s patients. Thirdly, in a new Feb. 28, 2019 publication of the same research group the population of Alzheimer’s disease patients had been enlarged to 94,437. This gives the study a higher statistical power. Previously the group had identified 20 genetic risk loci for late-onset Alzheimer’s disease (LOAD). In the 2019 study 5 new genetic loci for Alzheimer’s disease were identified. Specifically, one of them is the neurological and immune-mediated disease haplotype HLA-DR15. It is a risk factor for LOAD.

    Reconfirmation of some older Alzheimer’s research findings

    Notably, this latter finding shows that immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism are all sharing a connection in the development of late Alzheimer’s disease. In the past they have been implicated in the development of familiar Alzheimer’s disease. Now it became apparent that changes in the immune system, changes in the lipid metabolism and the onset of Alzheimer’s disease have an association also in late-onset Alzheimer’s disease. Research from 2016 showed that in obese patients the metabolic syndrome can indeed trigger the genotype CYP46 to develop Alzheimer’s disease.

    It seems that a variety of factors, like the CYP46 genotype and the metabolic syndrome with elevated cholesterol levels are interacting to cause amyloid beta plaques. In addition, neurofibrillary tangles from tau protein deposits are also part of the pathology of Alzheimer’s disease. These appear to lead to damage of nerve cells.

    Prevention of Alzheimer’s disease

    Inasmuch as it has become clear how many factors have to come together to trigger the development of Alzheimer’s disease, it is important to point out the factors that counter the development of Alzheimer’s.

    Several genetic loci have to work together to cause Alzheimer’s

    Research has defined many genetic loci tcyphat have impact on the development of Alzheimer’s disease. Researchers have stated that in order to develop Alzheimer’s disease several of these genes and risk factors that trigger the genes into action must occur in combination. This is in contrast to Parkinson’s disease or Huntington’s disease where only one genetic mutation causes the disease.

    Resveratrol

    Certainly, this powerful antioxidant from the skin of red grapes has a positive effect on early Alzheimer’s patients with improvement of their memory.

    Correction of hormone deficiencies

    With older age many of our hormones are decreasing or vanishing. But replacement of the missing hormones with bioidentical hormones has shown to prevent the onset of Alzheimer’s disease. This link explains that replacement of low testosterone in males and estrogen replacement in females is important to prevent Alzheimer’s. In addition, in women progesterone also has a neuroprotective function. Melatonin in both sexes is a powerful anti-oxidant hormone that preserves brain tissue. Thyroid hormone, if low, also needs replacement to maintain memory.

    Other lifestyle factors affecting the onset of Alzheimer’s disease

    Sugar and too much starchy food

    Heavy consumption of starchy foods like potatoes, rice, bread and pasta as well as sugar are risk major factors. They contribute to the early onset of Alzheimer’s disease. Sugar consumption (and starch, which gets metabolized within 30 minutes into sugar) causes oxidization of LDL cholesterol and plaque formation of all the blood vessels including the ones going to the brain. On the long-term this causes memory loss due to a lack of nutrients and oxygen flowing into the brain.

    Lack of exercise

    Lack of exercise is an independent risk factor for the development of Alzheimer’s disease. Exercise increases the blood supply to the brain, strengthens neural connections and leads to growth of neurons, the basic building blocks of the brain. Exercise also increases mood-regulating neurotransmitters like serotonin and endorphins.

    Vitamin D intake

    A 2014 study showed that a low vitamin D level had a strong association with a high risk of dementia and Alzheimer’s disease. Specifically, the findings were as follows.

    • Vitamin D level of less than 10 ng/ml: 122% increased risk of Alzheimer’s
    • Vitamin D level 10 to 20 ng/ml: 51% increased risk of Alzheimer’s

    The same research group found in two trials that vitamin D deficiency leads to visual memory decline, but not to verbal memory decline.

    Generally supplements of vitamin D3 of 5000 IU to 8000 IU are the norm now. But some patients are poor absorbers and they may require more- up to 15,000 IU per day. The physician can easily determine what the patient needs in the dosage of vitamin D3 by doing repeat vitamin D blood levels (as 25-hydroxy vitamin D levels). The goal is to reach a level of 50-80 ng/ml. The optimal level with regard to nmol/L is 80 to 200, according to Rocky Mountain Analytical, Calgary, AB, Canada.

    Sleep deprivation

    Sleep deprivation leads to memory loss, but so does the use of aspartame, the artificial sweetener of diet sodas. Make your own homemade lemonade. Squeeze the juice of half a lemon. Add mineral water to fill an 8 oz. glass. Add a tiny bit of stevia extract for sweetening. Stir and enjoy. Stevia has been in use for thousands of years and is non-toxic contrary to other artificial sweeteners.

    Avoid insulin overproduction

    I already mentioned the effect of sugar consumption above. But here I am mentioning it again because of the insulin reaction to sugar. An overload of refined carbs leads to an overstimulation of the pancreas pouring out insulin. Too much insulin (hyperinsulinemia) causes hormonal disbalance and leads to diabetes type 3, the more modern name for Alzheimer’s. All starch is broken down by amylase into sugar, which means that anybody who consumes starchy food gets a sugar rush as well. Too much sugar in the blood oxidizes LDL cholesterol, which leads to inflammation in the body. The consequence of chronic inflammation is as follows: hardening of the arteries, strokes, heart attacks, Alzheimer’s and brain atrophy, arthritis, Parkinson’s disease and cancer. It is because of this that a Mediterranean diet or a MIND diet is a sensible pollution for Alzheimer’s patients. Both of these diets have been shown to be anti-inflammatory.

    New Alzheimer's Genes

    New Alzheimer’s Genes

    Conclusion

    At the present time research knows of a total of 25 genetic risk genes for Alzheimer’s disease. It appears that they have to interact, and lifestyle factors can be a trigger to cause Alzheimer’s disease. This means that we can interfere with the development of Alzheimer’s disease. Get into some form of regular exercise like swimming, walking or Yoga exercises. Refrain from eating sweets and starchy foods. Adopt a Mediterranean diet or a MIND diet. Replace any missing hormones with bioidentical ones to re-establish your hormone balance. Watch your vitamin D3 intake. We need a lot more of it than what was previously known t to prevent the onset of this disease. Ensure you get enough sleep. This helps your brain to regenerate overnight. A resveratrol supplement every day will improve your memory, as a study has shown.

    These are some of the easy steps you can do to avoid getting Alzheimer’s disease.