• Side Effects of the Birth Control Pill

    Side Effects of the Birth Control Pill

    Dr. Jolene Brighten gave a lecture about side effects of the birth control pill. This was at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15th, 2019. Her exact title was “Your Body on Birth Control- … [Read More...]

  • Fasting Can Prevent Cardiovascular Diseases

    Fasting Can Prevent Cardiovascular Diseases

    Dr. Joel Kahn gave a lecture in Las Vegas in which he explained that fasting can prevent cardiovascular diseases. Dr. Kahn is a Clinical Professor of Medicine at Wayne State University School of Medicine. He spoke at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas. The conference took place from … [Read More...]

  • Coping with Covid-19 Coronavirus

    Coping with Covid-19 Coronavirus

    Recently the topic of coping with Covid-19 Coronavirus is at the forefront of our thinking. Coronaviruses are a group of viruses that lead to severe respiratory distress. The first known coronavirus appeared in 2003 and was called Severe Acute Respiratory Syndrome (SARS). It originated in China. The second one was … [Read More...]

  • Telomeres are Important

    Telomeres are Important

    In the first place, Dr. Joseph Raphaele reviewed why telomeres are important at a Conference in Las Vegas in December 2019. This was at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15, 2019. The actual title of his lecture was: “Telomeres in 2019; clinical developments and … [Read More...]

  • Eat Right for a Long Life

    Eat Right for a Long Life

    Dr. Felice Gersh gave a talk at a conference in Las Vegas stressing the importance to eat right for a long life. This was at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15th, 2019. The actual title of her presentation was “Nutrition for Longevity”. Dr. Gersh has a fellowship … [Read More...]

  • Celiac Disease in Various Disguises

    Celiac Disease in Various Disguises

    Dr. Tom O’Bryan gave a lecture in Las Vegas on Dec. 13, 2019 about celiac disease in various disguises. This was at the 27th Annual World Congress on Anti-Aging Medicine. The title of his talk: “An Ounce of Prevention Is Worth a Pound of Protocols: Halting Our Brains Slow Deterioration”. Case # 1: 44-year old male … [Read More...]

    Apr
    04
    2020

    Side Effects of the Birth Control Pill

    Dr. Jolene Brighten gave a lecture about side effects of the birth control pill. This was at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15th, 2019. Her exact title was “Your Body on Birth Control- What Prescribers Should Know About the Effects of Birth Control on the Female Body”.

    Most commonly the oral contraceptive pill is prescribed to prevent pregnancy. But the long-acting reversible contraceptives like the IUD and progestin implants are also popular. Depot Provera, the ring and the patch are the least popular ones.

    Why women use the birth control pill

    Women age 15 to 49 are often on some form of birth control method. 58% of women who use the birth control pill use it for reasons other than to prevent pregnancy. They use it to control symptoms of various conditions.

    • 31% use it for menstrual cramps
    • 28% want to regulate their periods
    • 14% hope to improve their acne
    • 4% use the pill for menstrual pains associated with endometriosis
    • 11% for other reasons

    What the birth control pill does

    The birth control pill exerts a negative influence on the hypothalamus and the pituitary gland. This is called “functional hypothalamic amenorrhea”. The birth control pill is not suitable to treat polycystic ovarian syndrome. Symptoms of bleeding may improve for 3 months, but after that the original symptoms return. Thyroid disease that may be present needs separate investigations.

    The hormones that are part of the birth control pill are synthetic hormones. They do not quite fit the body’s hormone receptors. For instance, the progestins, artificial analogues of progesterone behave like estrogens, not progesterone. This causes clotting problems cancers of the uterus, breasts and cervix. It can also cause heart attacks and strokes.

    List of side effects of the birth control pill 

    From depression to liver health

    The list of side effects of the birth control pill (BCP) is long. The BCP can worsen symptoms of depression and anxiety. The deeper the depression is, the higher is the risk for suicide. There is increased risk of hair loss. The BCP depletes nutrients in the body that the thyroid gland needs to produce thyroid hormones. This can result in hypothyroidism.

    It also increases thyroid binding globulin, a protein in the blood that binds thyroid hormones. As a result, there are fewer thyroid hormones available to the body cells. Breasts may become tender and enlarged after the start of the BCP. In some women with fibrocystic disease of the breasts the BCP may improve her cyclical breast changes. The BCP changes the liver both structurally and genetically. As a result, there is a higher risk of developing benign liver tumors and liver cancer.

    From gallstones to blood clots

    Women with a history of gallstones may experience faster gallstone formation on the BCP. The pill also can elevate your blood pressure. You should have blood pressure checks from time to time to prevent a stroke. Weight gain is common on the BCP. However, some women experience weight loss. Usually the BCP is 99% effective for the prevention of pregnancy. Pain from heavy periods or menstrual cramps are often relieved by the BCP. There is an increased risk to develop diabetes, because insulin resistance is gets worse in patients on the BCP. In postmenopausal women on HRT there is an even higher risk of developing diabetes. Blot clots are a common side effect of the BCP. Being a smoker, having a heart or liver condition, a history of genetic risk of blood clots, having migraines with an aura or being overweight are all additional risk factors for developing blood clots.

    From effects on the brain to cancer risks

    The BCP can change brain function and structure. This may lead to a different mate selection and production of neurotoxins. Some women get relief from hormonal headaches; but others experience exacerbations of migraines and headaches. In some women acne improves on the BCP; in others acne gets worse. When it comes to stress, some women experience an altered hypothalamic-pituitary-adrenal gland response from the BCP. The BCP reduces some cancer risks, like the risk of ovarian, uterine and colorectal cancer. But the risk for breast cancer, brain cancer and liver cancer are higher. The BCP increases gut permeability, leads to leaky gut syndrome and the disruption of the microbiome. There is often overgrowth of yeast in the gut. In addition, people with a genetic predisposition for autoimmune disease of the gut can develop immune diseases. Multiple studies have shown malabsorption of vitamins, minerals and antioxidants when on the BCP.

    From vaginal yeast infections to osteoporosis and autoimmune diseases

    Many women develop vaginal yeast infections. Women on the BCP often complain about low or a lack of libido. There can be vaginal dryness and pain with sex.

    Teenage women on the BCP often develop decreased bone density. Synthetic hormones lack the specificity to the natural hormone receptors, which leads to decreased bone density. On the other hand, bioidentical estrogen and bioidentical progesterone will indeed build up bone mass. In the past it was thought that hormones would be good for the bones and this is still true with the use of bioidentical hormones.

    A number of autoimmune diseases have been identified to be directly related to the use of the BCP. These are Crohn’s disease, multiple sclerosis, lupus, interstitial cystitis and ulcerative colitis.

    Synthetic hormones will always have side effects

    The body is a complex organism with various hormone receptors built into its cells. In order to be able to cash in on patented modified hormones Big Pharma introduced progestins to replace natural progesterone and various synthetic estrogen products to replace natural estradiol. However, the Women’s Health Initiative has shown  in 2002  that these artificial hormones produced heart attacks, strokes, blood clots, colorectal and endometrial cancer and hip fractures. There was an increase of mortality of 15% over 5.2 years compared to controls who did not take artificial hormones within the same timeframe.

    Bioidentical hormones have a perfect fit to the natural hormone receptors

    In contrast, when bioidentical hormones are given in menopause, there is a 10 to 15 year extension of life expectancy and researchers did not see any of the above mentioned side effects that were noted with synthetic hormones. Many people in Europe have elected to stick to bioidentical hormones for decades; they did not use the synthetic hormones. As a result, there are good data going back to the 1960’s about the safety of bioidentical hormones. In this study several thousand postmenopausal women were followed for 9 years or more and showed no increase in the rate of heart attacks or any cancer. Their postmenopausal symptoms were optimally controlled. I conclude from this that bioidentical hormone replacement in menopause will protect the women from missing hormones safely. There are no side effects and for this reason the bioidentical hormone replacement should become the standard of care.

    Side Effects of the Birth Control Pill

    Side Effects of the Birth Control Pill

    Conclusion

    Synthetic hormones have a long list of devastating side effects. Yet, Big Pharma managed to influence general practitioners and gynecologist to prescribe them to postmenopausal women. The Women’s Health Initiative has changed everything. The promise was that synthetic hormones would show heart-protective effects, cancer protective effects and healing effects for osteoporosis. These have been empty promises! None of this occurred with synthetic hormones- to the contrary! Many physicians are now prescribing bioidentical hormone replacement for women in menopause.

    No good alternative for teenage girls

    However, for teenage girls there is no good alternative for the traditional birth control pill, even though the catalogue of side effects is of serious concern. One compromise is to limit prescribing the birth control pill for up to 5 years only and then switch to several years of a copper T or other intrauterine device (IUD). Suicide in teenage girls on the BCP is of real concern. Despite the list of side effects many doctors continue to prescribe synthetic hormones for decades to the same patients, who trust that it will benefit them. In time patients will know about the side effects, and unfortunately many will experience them. As a result, it is only a matter of time, till this will be exposed as malpractice!

    Mar
    28
    2020

    Fasting Can Prevent Cardiovascular Diseases

    Dr. Joel Kahn gave a lecture in Las Vegas in which he explained that fasting can prevent cardiovascular diseases. Dr. Kahn is a Clinical Professor of Medicine at Wayne State University School of Medicine. He spoke at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas. The conference took place from Dec. 13 to 15th, 2019.

    According to the CDC cardiovascular diseases like heart attacks and strokes are hitting the middle age adults in large numbers. Part of the problem is obesity and diabetes, both of which cause an increase of cardiovascular diseases. Heart attacks, strokes, heart failure and other related cardiovascular conditions caused 2.2 million hospitalizations in the US in 2016. This resulted in 415,000 deaths and a health care cost of $32.7 billion.

    Fasting can improve the risk for cardiovascular disease

    Dr. Kahn asked whether fasting can reduce the aging pathways, build up resilience and protect the heart from aging and heart disease. In a few words: eat less, live more! He showed with slides that fasting can indeed do that. One heart catheterization study showed that a fasting group had only 64% coronary artery disease compared to a non-fasting control group with 76%.

    Another study showed that fasting patients had only 10.3% diabetes compared to controls with 22.0%. With heart catheterization 63.2% of fasting patients had cardiovascular disease while 75.0% of non-fasting control patients did have lesions in their coronary arteries.

    Animal experiments confirmed that fasting had beneficial effects on heart health as well. In rats, researchers showed that fasting reduced infarct size and inflammation. It also preserved left ventricular function. With mice fasting produced less inflammatory response and less tissue damage.

    Alternate day fasting shows benefit in clinical human trial

    A 2019 publication reported about a 4-week randomized clinical trial on 60 healthy non-obese human subjects. The effect of alternate day fasting was compared to controls. On average there was a 37% calorie reduction in the alternate fasting group. The fasting group had improved fat mass, improved fat-to-lean ratio and cardiovascular markers. There was a reduction of age-associated inflammatory markers and low-density lipoprotein.

    Fasting mimicking diet

    A newer form of fasting is the fasting mimicking diet (FMD), which was invented and researched in depth by Dr. Valter Longo. Both animal experiments as well as human trials have shown that the FMD is safe and effective. It can be followed 5 days out of every month and will lead to some weight loss, an increase of telomeres, stem cells and lowered inflammatory markers.

    My own experience with the fasting mimicking diet

    My wife and I heard about the FMD from Dr. Longo when he spoke about it at the 2017 Anti-Aging Conference in Las Vegas. We immediately started the FMD in December of 2017 and have done it every month for 5 days since. But we never ordered the expensive meal kit. Instead, we calculated calories and use regular food to do the calorie-restricted diet. We eat 600 to 700 calories every day during the FMD days. In between we have unrestricted calories, but we noticed that we are more careful about our meal choices. I find that the result of the FMD is more energy, an improved sleep pattern and an easier way to keep my body-mass index in the 21.0 to 22.0 range. Here is a description of the effects of the FMD.

    Use of FMD in high-risk patients

    Dr. Khan said that the FMD is an ideal diet that the high-risk population of the US should use. 34% of the US population has a compromised metabolic condition. They are obese and at a high risk to develop diabetes. But on the FMD they gradually lose abdominal obesity, lower their cholesterol and triglycerides levels, which otherwise causes a high risk for heart attacks and strokes. The fasting blood sugar is lowering reducing the risk to get diabetes. The systolic and diastolic blood pressure comes down. And the C-reactive protein, which is a general inflammatory marker, becomes lower.

    In non-obese patients the main effect of the FMD is a stimulation of stem cell release and telomere elongation. This postpones the aging process and with it delays the onset of cardiovascular diseases.

    Fasting Can Prevent Cardiovascular Diseases

    Fasting Can Prevent Cardiovascular Diseases

    Conclusion

    Dr. Joel Kahn gave a lecture at a Las Vegas conference that fasting can prevent cardiovascular diseases. He compared alternate day fasting with the fasting mimicking diet (FMD). The FMD was more effective in reducing danger markers, abdominal girth measurements and blood markers of cardiovascular diseases. Ultimately, he said, it was easier to follow an FMD where you only reduce your calorie intake to 600 to 700 calories per day for 5 days in one month. In those who are wanting to do this just for good health, the FMD increases stem cells and elongates telomeres. This postpones the aging process and keeps a person younger for longer. At the same time, it delays the onset of cardiovascular diseases.

    Mar
    21
    2020

    Coping with Covid-19 Coronavirus

    Recently the topic of coping with Covid-19 Coronavirus is at the forefront of our thinking. Coronaviruses are a group of viruses that lead to severe respiratory distress. The first known coronavirus appeared in 2003 and was called Severe Acute Respiratory Syndrome (SARS). It originated in China. The second one was called Middle East Respiratory Syndrome (MERS), which began in Saudi Arabia in 2012. Covid-19 Coronavirus started in December 2019 in Wuhan, China.

    The Wuhan market in Wuhan, China

    This link contains a walk-around in the Wuhan market, where’re all kinds of animal parts are sold for the peculiar taste of Chinese connoisseurs. Unfortunately, it may be the mix of infected animal parts and crowds of humans that can lead to endemics like SARS or Covid-19 Coronavirus.

    Covid-19 Coronavirus is a variation of a general flu virus. Coronavirus attaches to the mucous membranes of the nasal cavity, the sinus cavities and the pharynx. It sets up an inflammatory reaction of the mucous membrane cells. The cold-like symptoms in the head occur around the 5th day of infection, but sometimes there is a longer incubation and the cold-like symptoms occur only around day 10. A high fever and a cough are next. Next it affects the mucous membranes of the voice box, the trachea, the bronchial tubes and finally of the alveoli (the tiny air sacs of the lungs).

    Viral pneumonia causes mortality

    It is this inflammation of the alveoli, which can make a person dangerously sick. If the virus is stronger than your immune system, you can get viral pneumonia. With this condition there are a lot of secretions that must be coughed up or else there is not enough surface in the lungs to absorb oxygen. You can literally drown in your own secretions. It is the inflammation in the lungs, called viral pneumonia, which kills many patients.

    Antiviral medication

    Regular antibiotics will not help for a viral flu, whether this is the influenza virus or the Covid-19 Coronavirus. But antiviral medication like oseltamivir (Tamiflu), zanamivir (Relenza), or peramivir (Rapivab) might help. Despite these efforts the death rate of the ordinary influenza virus infection is about 0.13 %, as the Centers for Disease Control have calculated. In comparison, SARS had a mortality rate of 7.5 to 10% and MERS a mortality rate of 35%. The present new variation of a coronavirus has a mortality around 3.7% in China and 1.9%, outside of China according to the WHO.

    Interception of the multiplication of Covid-19 coronavirus

    Why wait until the virus has traveled from the top (nose, sinuses) to the bottom (lungs)? There is a mega vitamin D3 dose therapy that became popular when the SARS epidemic was around. It was originally developed for influenza.

    Recently I came down with a cold, when I remembered that you can fight the cold or flu with mega vitamin D3 doses. The cold did not fit into my plans. I was three days before singing as a lead singer in a local church and I needed my voice. I felt a burning in the back of my throat and knew I was coming down with a cold. Next I felt congested in my nose and sinuses.

    Experience of the mega vitamin D3 therapy

    I braced myself for the cold affecting my voice box and taking my voice away. But on the second day of the cold/flu I took 50,000 IU of vitamin D3. The following day the congestion was still confined to my nose and sinuses only. But it did not go further down into my throat or chest. I continued my dose of 50,000 vitamin D3 for the second day and a 3rd dose on the 3rd day. The mega vitamin D3 doses saved my voice. My cold/flu never progressed any further; it simply stopped.

    Slow and fast absorbers of vitamin D3

    I know that I am a slow absorber of vitamin D3 and normally need 10,000 IU daily to get into the normal range of 25-hydroxy vitamin D using a blood test. My cold symptoms settled down, there was no sign of laryngitis, where you sound scratchy. I also did not get a cough, which based on my past experience, would have lingered on for weeks. Other people who are fast absorbers get effective 25-hydroxy vitamin D blood levels with daily doses of only 4,000 IU or 5,000 IU. However, for the mega dose vitamin D3 therapy these subtle differences don’t matter. The whopping dose of vitamin D3 leads to a high 25-hydroxy vitamin D levels that last about 2 months.

    Mechanism of stimulation of the immune system by mega vitamin D3 therapy

    Taking high doses of vitamin D3 releases cathelicidin and defensins. These are polypeptides that have antibacterial and antiviral properties. The vitamin D antimicrobial pathway is described in this link. Vitamin D stimulates the immune system (B cells and T cells), which can suppress viral and bacterial infections. Dr. Thornburg describes that an adult should treat a cold/flu within 24 to 36 hours after onset with 50,000 IU of vitamin D3 once daily for 3 days. He also lists pediatric doses. A 30 lb child would receive 1/5th of the adult dose or 10,000 IU once a day for three days.

    Following this treatment, the patient resumes the previous vitamin D3 maintenance dose.

    Opinion of conventional medicine

    The Mega vitamin D3 therapy approach is not part of conventional medicine. Here is a publication that states that Vitamin D, Vitamin C, Zinc, and Echinacea in combination can be useful in the treatment of the common cold. But the section that describes the use of vitamin D seems to be very conservative. It does not even mention the importance of measuring the vitamin D blood levels.

    25-hydroxy vitamin D blood level

    Without a 25-hydroxy vitamin D levels the physician cannot determine whether or not you have adequate vitamin D blood levels. The normal level is considered to be 25-80 ng/mL. Many physicians say a level of 50-80 ng/mL is better (higher end of normal). This blood test will measure the sum of vitamin D from oral vitamin D3 and from sun-induced vitamin D. This test also reveals whether a person is a fast or a slow absorber. What counts is that a person taking vitamin D3 gets the blood level into the therapeutic range.

    Vitamin D Toxicity 

    Are there toxic levels of vitamin D? Whenever the topic of mega dose vitamin D3 is mentioned, conventional medicine will warn that vitamin D toxicity could develop including kidney stones and “bone pain, drowsiness, continuous headaches, irregular heartbeat, loss of appetite, muscle and joint pains.” In these cases of toxicity the researchers did not indicate what the level of 25-hydroxy vitamin D level was. Other publications have established that the original recommended dose of vitamin D3 by the Food and Nutrition Board of 2000 IU per day was way too low.

    According to this publication based on many other papers 10,000 IU per day or more should be considered the new recommendation.

    Vitamin D3 Mega dose

    Dr. Schwalfenberg stated: “This is a 1-time 50,000 IU dose of vitamin D3 or 10, 000 IU 3 times daily for 2 to 3 days. The results are dramatic, with complete resolution of symptoms in 48 to 72 hours. One-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.” The half-life of 25-hydroxy-vitamin D3 is 15.1 days. This means that the transient elevation of 25-hydroxy-vitamin D3 will last only 5 half-lives or 75.5 days. After that time (2 1/2 months) the body has eliminated the mega dose of vitamin D3.

    Community-based measures to reduce spread of Covid-19

    There are several measures that help to stop the spread of Codi-19 Coronavirus. As our hands are often transmitting flu bugs to our eyes or mouth, it is important to wash our hands frequently with soap and water. And do not touch your face!

    Coughing, sneezing

    Cough or sneeze into your bent elbow, not your hands or into a Kleenex.

    Cleaning your home

    Frequently clean toilet seats, light switches, door knobs and bedside tables. These are the items that are most frequently touched. Phones, computers and other devices should be wiped down with alcohol prep wipes (70% alcohol).

    Social distancing

    When Covid-19 Coronavirus is spreading in a community, it is important that people avoid large gatherings. This often includes school closures and closures of theatres, sports facilities etc. Droplets can fall up to 2 meters (6 ½ feet) from the mouth of an infected person. It makes sense that an infected person wears a mask to retain larger droplets with viruses, but the virus is small enough to directly penetrate a regular mask. The recommendation right now is that people who are self-isolating, but have no symptoms do not wear a mask. Masks are in short supply worldwide.

    Self-quarantining

    Many countries also recommend that all overseas travellers who come back home should voluntarily self-quarantine themselves for 14 days and watch for symptoms. The main two symptoms are a high fever and a persistent cough. Take your temperature once or twice daily when in self-quarantine. Make sure you have a friend bring you food items and whatever you need from a grocery store. If you are on regular medicine, talk to your pharmacist how this can be home delivered or picked up by a friend.

    Vaccine development against Covid-19 Coronavirus

    Vaccines against Covid-19 Coronavirus are still one year or more away from mass production. In April 2020 one of the vaccine manufacturer, Moderna will start testing on humans in the US. But it will take until next year before this vaccine will be available to everybody.

    Another approach to help patients with Covid-19 Coronavirus infection is a plasma-derived hyperimmunoglobulin therapy.  Antibodies from patients who recently recovered from a Coronavirus infection are the basis for this treatment. Takeda, Japan’s largest drug manufacturer, announced on March 4, 2020 that it would develop a hyperimmunoglobulin against Covid-19 Coronavirus.  Recently recovered patients have specific antibodies in their blood, which the company can recover from their plasma. When physicians inject the recovery plasma into patients with a positive test against Covid-19 Coronavirus, their recovery accelerates and the course of the infection is much milder. This new therapy was dubbed “TAK-888”. However, testing requires still many more month of further research to ensure it is safe.

    Why does Italy have high Corona death rates?

    In the March 18, 2020 issue of the German Magazine stern.de this question was posed. There are 31,500 Italians with the Coronavirus infection so far. 2503 people died from the Covid-19 Coronavirus. This translates into a mortality rate of around 8%, which is more than double of average rate of in other countries. For comparison, here are the death rates in other countries: China 4%, South Korea 1% and Germany 0.26%. Why these tremendous differences?

    Low testing rates

    Scientists believe that the policy in Italy to only test patients with symptoms suppresses the number of reported infected patients. This leads to unreported cases and falsely reporting higher Corona death rates. In South Korea where mortality rates are low, physicians did 3692 tests for Covid-19 per a million people up to March 8, 2020. In contrast, health professionals in Italy did only 826 Corona tests per million people. This leads to underreporting of infected people, causes more transmissions and higher death rates. Dr. Jeffrey Shaman, an epidemiologist at Columbia University said: “If we have 3,500 confirmed cases in the U.S., you might be looking at 35,000 in reality”.

    Physicians in the US do not test enough people for Covid-19, and like in Italy this will lead to much higher infection rates as assumed to occur in the beginning.

    Seniors are at higher risk for mortality from Covid-19 Coronavirus

    According a report from the UN in 2015 there were 28.6% of the Italian population were 60 years or older. In South Korea 18.5% of People were older than 60 at the same time. Seniors have other underlying diseases like type 2 diabetes, emphysema, heart disease and others. When patients with these conditions get Covid-19 Coronavirus, the mortality is higher. Children and people below the age of 60 may have clinically undetectable disease, and only a Covid-19 test would show it, if they were positive.

    Coping with Covid-19 Coronavirus

    Coping with Covid-19 Coronavirus

    Conclusion

    Vitamin D3 has long recognition as a stimulant of the immune system. We now know that high doses of vitamin D3 release two polypeptides, cathelicidin and defensins. They have antibacterial and antiviral actions. Several physicians have developed a mega vitamin D3 approach when a cold or flu just starts to hit you. An adult should then take 50,000 IU of vitamin D3 daily for 3 days. In many cases it will cut the cold/flu short within 48 to 72 hours. Dr. Schwalfenberg said that “one-time doses of vitamin D at this level have been used safely and have never been shown to be toxic.”

    Inflammation from Covid-19 Coronavirus

    Any flu virus, including the coronavirus varieties, cause a lot of inflammation. When the inflammation reaches the lungs (inflammation of the air sacs or alveoli) a lot of patients die because they cannot get enough air. But with the use of mega vitamin D3 doses we have a powerful tool to prevent the further spread of the virus. If you take this on the first or second day of the flu, you can prevent the further spread of the coronavirus into the lungs. The reason is the release of cathelicidin and defensins from the action of vitamin D3. These polypeptides have antibacterial and antiviral properties.

    Vaccine development

    Vaccine development is still a year away from being available. In the meantime, high dose vitamin D3 therapy is available and is cheap.

    Most importantly, help stop the spread by being meticulous about your hygiene, as mentioned before. Also, adjust your life style by staying away from larger crowds. You will not hang out in bars and clubs, and instead of going out for meals, prepare your own or arrange for food delivery. Panic never helped in crisis situations; common sense does!

    More information

    Mar
    14
    2020

    Telomeres are Important

    In the first place, Dr. Joseph Raphaele reviewed why telomeres are important at a Conference in Las Vegas in December 2019. This was at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15, 2019. The actual title of his lecture was: “Telomeres in 2019; clinical developments and cutting-edge applications”.

    Notably, Dr. Raphaele reviewed how various animals have quite different life expectancies. First, the Aldabra giant tortoises, for instance can live up to 152 years. Second, the house mouse can at the most live up to 6 years, but its predator, the cat lives up to 38 years. Finally, humans can live up to 122.5 years.That is to say, the average mortality rate doubling curve of man is 8 years. Dr. Raphaele introduced the terms “lifespan” and “health-span”.

    Lifespan versus health-span

    The first thing to remember is that our lifespan is defined by the number of years we live. On the contrary, the health-span is defined by the number of years you do not have any disease and your physical and mental health are good. Dr. Raphaele explained that for the most part the body’s organs have a limit of functioning after 80. For this reason the kidneys, the maximum heart rate, the maximum breathing capacity and the maximum work rate (oxygen uptake) all decline after the age of 80. It is important to realize that in 1961 Dr. Leonard Hayflick showed that there is a limit of how often cells can divide. After 60 doublings cells in tissue culture either die or just stop dividing. The built-in molecular clock resides in the telomeres. The telomeres are the caps at the end of the chromosomes in the cell’s nucleus.

    Telomeres and their function in aging

    In a word, what is the function of telomeres? In essence, the telomeres protect the integrity of our genes. For the most part, they protect the chromosomes from deteriorating, prevent DNA fusion and massive instability of the genes. In addition, the telomeres allow the cells to divide in an orderly fashion, but only up to the Hayflick limits. In short, the bottom line is that telomeres prevent cells from mutations of the DNA, from senescence and from death.

    Shortening of telomere length with age

    Dr. Raphaele said that one of the important findings was that telomere length is shortening with age. Notably, he showed a slide similar to this. To clarify, this graph shows telomere length as a function of the lifespan in years. The telomere length is obtained by a blood test. This determines the length of the telomeres in white blood cells. At a young age it has a length of between 8 and 10 kb. kb stands for kilobase. A kilobase consists of 1,000 pairs of nucleic acid sequences. So, 10 kb means 10,000 pairs of nucleic acid sequences. Around the age of 80 people have much shorter telomeres, only 4 to 6 kb. There is an enzyme, called telomerase that can elongate telomeres by approximately 10%. But this may not be desirable as too much telomerase activation can also stimulate cancer growth.

    Age changes telomere length

    Dr. Raphaele explained further that a telomere loses about 100 base pairs per cell division. But there are other factors that shorten telomeres. Smoking, sedentary lifestyle, high blood pressure, stress and a low antioxidant status all can shorten telomeres. Certain congenital conditions can shorten telomeres by 28%. Dyskeratosis congenita is such a condition where 80% patients die by the age of 30 due to aplastic anemia. This is associated with bone marrow failure. 10% of these patients die from cancer. Apart from age, which shortens telomeres slowly, lifestyle factors are very important. A good lifestyle where you exercise regularly, you don’t smoke and you eat a healthy diet will slow down the shortening of your telomeres. Controlling your stress, sleeping enough hours per night and taking supplements also delays telomere shortening. Certain medications that control diabetes, high blood pressure or thyroid medication that treats hypothyroidism also delay telomere shortening.

    Telomeres and shortened lifespan

    Researchers could show that good lifestyle practices work by increasing telomerase to a certain degree. This results in lengthening of telomeres and translates into up to 10 years of increased life span. Jerry Shay, PhD said in 2011: “While the aging process is complex and certainly cannot be explained solely on the basis of telomere biology, there is a growing consensus that in some situations telomere biology and telomere tests may have important utility similar to cholesterol assays or blood pressure monitoring measurements.”

    Telomeres are not just a biological clock inside our cells. They have a great influence on the function of mitochondria and on how many mitochondria multiply inside cells. This latter process is called mitochondrial biogenesis. In addition, telomeres regulate gene expression.

    Chronic diseases associated with shortened telomeres

    Here is a list of chronic diseases where all the patients have shortened telomeres.

    • High blood pressure
    • Hardening of the arteries (atherosclerosis)
    • Cancer
    • Chronic obstructive pulmonary disease (COPD)
    • Alzheimer’s disease
    • Diabetes and obesity
    • Chronic stress
    • Metabolic syndrome

    Telomeres in cardiovascular disease

    Telomere length was found to be shortened in those who developed a heart attack. Researchers compared the telomere length in coronary artery disease (CAD) patients to people with no history of heart attacks. In comparison to this normal group the heart attack victims had telomeres typical for people who are chronologically 11.3 years older than the healthy controls. The researchers calculated that people with telomere shortening had a 3-fold higher risk of coming down with a heart attack.

    Telomere length enhancers

    1. Lifestyle changes can have positive effects on telomere length. Examples are smoking cessation, weight loss and stress reduction.
    2. Dietary changes: we know that fish oil (omega-3 fatty acids) supplements elongate telomeres as does a low-fat diet.
    3. Supplements like vitamin D3, antioxidants (vitamin C and E) and astragalus (TA-65) elongate telomeres as well. The astragalus supplement, TA-65 showed a significant elongation of telomeres after 12 months while controls lost telomere length.
    4. Exercise: in a 24-week experiment of care workers regular aerobic exercise increased the telomeres by 67.3 base pairs.
    5. Bioidentical hormone replacement in aging people: when hormones are missing after andropause and menopause, the natural hormones need replacing, or the telomeres are shortening.
    6. High cortisol levels cause telomere shortening.
    7. Human growth hormone elongates telomeres via telomerase activation.
    8. The fasting mimicking diet (FMD) was shown to extend life and telomeres as well.

    Therapeutic rationale for telomere lengthening in CAD and AD

    Patients with coronary artery disease (CAD) are at risk for developing heart attacks and other cardiovascular diseases. Here is an overview of many clinical trials that have been done in humans with CAD. It shows shortening of telomeres in these high-risk patients. But the review also shows that telomeres can lengthen by changing the risk factors of cardiovascular disease. Researchers were increasing the enzyme telomerase that indirectly lengthens telomeres. Both approaches prevent serious cardiovascular disease and increase life expectancy significantly. In severe cases of telomere shortening the physician can consider TERT gene therapy.

    Alzheimer’s disease (AD) also is a condition where telomeres are shortened compared to normal controls. Time will tell whether TERT gene therapy is possible to prevent Alzheimer’s disease.

    Telomeres are Important

    Telomeres are Important

    Conclusion

    Telomeres are the caps of the chromosomes in our cells. In the past the word “telomere” appeared obscure and only scientists discussed this among themselves. Now we know that telomere shortening is often the reason for chronic illnesses like high blood pressure, hardening of the arteries (atherosclerosis), cancer, chronic obstructive pulmonary disease (COPD), Alzheimer’s disease, diabetes and obesity. Patients who have these conditions often have shortened telomeres in their white blood cells. Over the years we have learnt that lifestyle changes can have positive effects on telomere length. Smoking cessation, exercise, weight loss and stress reduction are elongating telomeres.

    Additional factors elongating telomeres

    In addition, supplements like antioxidants (vitamin C and E), vitamin D3 and astragalus root (TA-65) elongate telomeres as well. By elongating telomeres, a person can add 10 to 11 years of disease-free life to the normal life expectancy. Researchers showed that telomerase activation by human growth hormone increased telomere length without causing cancer. Dr. Thierry Hertoghe, an endocrinologist from Belgium spoke about HGH replacement in aging people on other occasions. He said that cautiously treating patients with low doses of HGH when blood tests showed deficiency, adds about two decades of life-expectancy to these patients’ lives.

    Mar
    07
    2020

    Eat Right for a Long Life

    Dr. Felice Gersh gave a talk at a conference in Las Vegas stressing the importance to eat right for a long life. This was at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15th, 2019. The actual title of her presentation was “Nutrition for Longevity”.
    Dr. Gersh has a fellowship in Integrative Medicine at the University of Arizona School of Medicine.

    In the first place she pointed out that an anti-inflammatory diet consists of vegetables, fruits, nuts, whole grains, healthy oils like olive oil and fish. This is a modified Mediterranean diet. On the other hand, with a pro-inflammatory diet or Western diet, you eat high fat, cholesterol, lots of protein from red beef, high sugar, excessive salt and a lot of processed and fast-food.

    Prevention of diseases

    It is important to realize that for prevention of cardiovascular disease, cancer and degenerative diseases you need to eat fruits and vegetables, which contain important phytochemicals. They contain a wide variety of molecules, like carotenoids, vitamins and polyphenols. Another key point is that cruciferous vegetables (broccoli, Brussels sprouts, and kale) contain glucosinolates, which are sulfur-containing compounds. They protect you from cancer.

    Vitamins and magnesium

    It must be remembered that in order to strengthen the immune system and prevent hardening of the arteries (atherosclerosis) we need the following: omega-3 and omega-6 fatty acids, the enzyme Co-Q10, vitamin A, B complex, C, D, E, carotenoids, phytosterols, stilbenes and flavonoids. Another key point is that magnesium is extremely important. Many of our dietary habits have reduced magnesium intake to a minimum. Our soils are depleted of magnesium, it is no longer in drinking water, and it is absent in processed foods. However, magnesium is involved as a co-factor in more than 700 enzymatic reactions in our bodies. Magnesium is involved in heart contractions, is important to maintain our blood pressure and is important for glycemic control. It is also important for bone development and for DNA and RNA synthesis. Magnesium binds serotonin and dopamine to their receptors and plays a role in many more body functions.

    Brassica vegetables

    This group of vegetables consists of broccoli, cauliflower, green cabbage and Brussels sprouts. Notably, they have long been recognized to lower the risk of many cancers. The first thing to remember is that the active ingredients in them are glucosinolates and isothiocyanates. Certainly, food preparation has a lot of influence on maintaining beneficial substances in the brassica vegetables. To emphasize, finely shredded vegetables had a marked decline of their glucosinolate levels by 75% within only 6 hours. On the negative side, microwave cooking destroys 74% of glucosinolates, but on the positive side, storage in room air preserves almost all of the glucosinolates for 1 week. In addition, stir frying brassica also preserves the glucosinolates. This reference points out how fruit and vegetables can contribute to cancer prevention.

    The gut microbiome

    The Western diet leads to a change in the gut flora with Gram-negative bacteria taking over the healthy gut flora and disrupting the intestinal barrier. To emphasize, this result is called endotoxemia. Part of this is increased serum endotoxin, which mainly consists of lipopolysaccharides. Indeed, it causes gut inflammation and a breakdown of the gut barrier. When this happens, autoimmune antibodies are produced. To put it another way, the Western diet undermines your health. In a word, high fat foods and added sugars (refined carbohydrates) lead to increased Gram-negative bacteria and the disruption of the intestinal barrier.

    An unhealthy diet causes disease

    In the long run this causes autoimmune diseases, leads to higher heart attack rates and to diabetes. Healthy gut bacteria in fact help to digest fibre, which leads to three short-chain fatty acids: butyrate, acetate and propionate. For the most part, they are important as energy source, affect cardiometabolic health and appetite. On balance, butyrate also helps to maintain the blood brain barrier.

    Importance of fiber

    Higher fiber content in food leads to less cardiovascular disease, has positive effects on obesity and the metabolic syndrome. Fiber changes the microbiome in the gut, leads to less gut permeability and more short-chain fatty acids production.

    The best diet

    • 60% to 70% complex carbohydrates are the foundation of a healthy diet. It consists of vegetables, green leafy and root vegetables, beans, legumes, whole grains and fruit.
    • Eat healthy fats from nuts, olives, seeds, krill or fish oil. Limit fat intake to 18 to 28% of your daily calorie intake. Avoid hydrogenated fats. Limit your saturated fatty acid intake. 85% chocolate is OK. Otherwise consume olive oil and omega-3 fatty acid containing foods (from seafood and fish).
    • Add about 12% of the daily calorie consumption as protein per day. Choose fish, seafood, lean cuts of chicken, only the occasional red meat (organic or grass-fed meat)
    • Eat lots of fiber, eat organic and minimally processed food. Limit sugar, fat and salt. Avoid antibiotics from the agricultural industry, sweeteners, gluten and excessive alcohol intake. Take a daily probiotic and eat probiotic food. Eat three meals a day, a big breakfast, a moderately-sized lunch and a small dinner. A fasting mimicking diet once per month for 5 days activates your longevity genes.
    Eat Right for a Long Life

    Eat Right for a Long Life

    Conclusion

    Dr. Felice Gersh gave a talk at a conference in Las Vegas. This was at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15th, 2019. She said that we need to eat right for a long life. She gave a thorough outline of what to eat and what not to eat. It is important to note that she suggested to cut out additional refined sugar and processed food. The bacteria in the gut must be normal, or the gut barrier breaks down. This failure can cause autoimmune diseases. Eating lots of vegetables and fruit as well as fiber will help to keep your gut bacteria normal.

    What foods to eat

    A Mediterranean type diet gives you the right foods that you need for your health. Avoid the Standard American diet as it is unhealthy and kills the good gut bacteria. Brassica vegetables like broccoli, cauliflower, green cabbage and Brussels sprouts prevent the development of many cancers. Eat three meals a day, a big breakfast, a moderately-sized lunch and a small dinner. This fits best into the diurnal rhythm of your gut bacteria.

     

    Feb
    29
    2020

    Celiac Disease in Various Disguises

    Dr. Tom O’Bryan gave a lecture in Las Vegas on Dec. 13, 2019 about celiac disease in various disguises. This was at the 27th Annual World Congress on Anti-Aging Medicine. The title of his talk: “An Ounce of Prevention Is Worth a Pound of Protocols: Halting Our Brains Slow Deterioration”.

    Case # 1: 44-year old male with an assumed diagnosis of ALS

    In the first place a 44-year old male had a history of a right leg weakness that developed over the last 6 months. He had intermittent spasms in his right quadriceps muscle. In addition, over the last few months he noticed a weakness develop in his right arm with difficulties writing. Significantly, his family history revealed that a maternal aunt had celiac disease. Moreover, a sister had Crohn’s disease and his maternal grandmother had multiple sclerosis. Electromyographic studies showed widespread acute denervation. An MRI scan of the spine showed hyperintensity in the corticospinal tracts. A diagnosis of amyotrophic lateral sclerosis (ALS) followed as a result based on the MRI scan findings.

    Further tests

    At the same time blood tests revealed that his anti-endomysial antibodies were elevated.  Duodenal biopsy demonstrated villous atrophy, crypt-hyperplasia and increased intraepithelial lymphocytes consistent with gluten-sensitive enteropathy (celiac disease). An MRI scan of the brain also showed some hyperintense lesion in the left-brain hemisphere.

    Gluten free diet instituted

    It was clear with these test results that the initial diagnosis was a misdiagnosis. The real diagnosis was celiac disease. 7 months after the onset of his symptoms he started on a gluten free diet. He received no medications. Notably, his right arm function returned to normal after 9 month of the gluten free diet. Although there was some improvement in his right leg function, he still had some muscle wasting and spasticity in his right leg. However, he could now walk without any aid. His hand-writing was back to normal, and he could button his shirts again. Repeat MRI scans followed 2 months and 9 months after the start of the gluten free diet. At two months after initiation of the gluten free diet the brain lesion in the left brain was somewhat larger than before, but at 9 months it was half the original size.

    Case #2: Autism in children, youth depression and Alzheimer’s patients

    The autism spectrum disorder (ASD) has significantly increased from 1 in 166 in 2004 to 1 in 40 in 2018. In addition, Dr. O’Bryan also mentioned that in 2017 statistics showed that 13.3% among youth aged 12 to 17 in the US suffered major depressive episodes. 1 in every 12 youth suffer from severe behavioral and emotional problems. According to the CDC since 1994 the number of children on psycho-stimulants increased 5-fold. In the same time children under 18 with bipolar disorder have increased 40-fold. There has been a 6-fold increase of prescriptions for antipsychotic medications for children in the same time frame.

    Other effects on adolescents

    However, I like to point out that there are other powerful factors that can explain increased depression and emotional problems in adolescence. The Canadian Medical Association published an article about social media and smart phones and the effects they have on adolescence.

    On the other end of the life cycle 1 in 3 seniors die with Alzheimer’s disease or dementia. Between 2000 and 2015 death from Alzheimer’s disease has increased by 213%.

    Breakdown of the blood brain barrier

    According to Dr. O’Bryan autism in children, behavioral and emotional problems in teenagers and dementia from Alzheimer’s disease are all related to the same process, namely a breakdown of the gut barrier, often called leaky gut syndrome. It is important to realize that this leads to a secondary breakdown of the blood brain barrier. The end result is a compromise of the brain, where antibodies attack the brain protein. In young children this causes lower adaptive and cognitive function and behaviors typical for autism. Teenagers are more likely to present with depression or schizophrenia. In older people the breakdown of the blood brain barrier can result in Alzheimer’s disease and other forms of dementia.

    25 to 30% of protein in wheat are non-gluten. Antibodies can be directed against gluten, but also against non-gluten protein.

    IgG antibodies against gluten cross placenta

    In the later stages of pregnancy IgG antibodies cross the placenta easily. They provide passive immunity from various viral infections. Unfortunately, antibodies against gluten also cross through the placenta, which can lead to a breakdown of the fetal gut lining, in the sense of leaky gut syndrome. In this study 211 children were found to have a risk of 1.7-fold to develop psychosis later in life. The mothers were positive for anti-gliadin IgG antibodies in the last 4 weeks of pregnancy. Anti-casein antibodies did not have this psychosis effect (risk only 0.8-fold). The investigators felt that an allergy to wheat in the mother set up general inflammation. Psychosis in the offspring only develops when inflammatory mediators reached the brain of the fetus. It was the brain inflammation, which caused the subsequent psychosis later in the child.

    Blood brain barrier and healthy gut barrier

    Another key point is that the barrier both in the gut and in the blood brain barrier consists of a single epithelial layer. The cells are held together by zonulin and occludin proteins. Autistic children were exposed already in the uterus to mother’s wheat induced anti-gliadin antibodies. This led to a break-down of the children’s blood brain barrier and the symptoms of the autism spectrum disorder. These children have a lot of brain inflammation and in addition often have impaired gut barrier integrity. It must be remembered that they require a comprehensive program to improve the gut flora, build up the gut barrier integrity and re-establish the blood brain barrier.

    Effects of phthalates on young children

    A 2014 study measured urinary metabolites of phthalates and related this to the children when they were 7 years old.

    The investigators did several cognitive tests and measured the IQ (Wechsler Intelligence Scale). Children of mothers with the highest quartile of phthalates had an IQ, which was on average 7.0 points lower than the control group of the lowest quartile of phthalates. Dr. O’Bryan showed a slide taken from this study.

    With this in mind, it points out that a pregnant woman has an intact blood brain barrier, which prevents antibodies from entering. However, the immature brain of the fetus has not developed an efficient blood brain barrier yet. This allows maternal gliadin antibodies from wheat intolerance to enter the fetal brain and cause autism spectrum disorder (ASD).

    PCB’s disrupt the blood brain barrier

    In mouse experiments the effects of PCB’s were investigated. By the same token, researchers found that the blood brain barrier was broken down by PCB’s that are known to have carcinogenic and neurotoxic properties on the brain. The researchers injected melanoma cells into the animals and found that the PCB pretreated mice sustained brain metastases. However, the control animals that did not have PCB pre-treatment did not develop brain metastases. They concluded from this that PCB’s are breaking down the blood brain barrier.

    Maternal brain antibodies causing autism in children

    This publication examined antibodies to two different brain proteins. The researchers found that 86% of the children from mothers with two different fetal brain antibodies were diagnosed with autistic regression. According to this publication there are at least 50 different epitopes of gluten peptides that exert cytotoxic, gut permeating and immunomodulatory activities.

    DNA microarray technology can now detect many subtypes of food disorders and gluten sensitivities. The tests for celiac disease have a sensitivity of 97% for IgG and 99% for IgA. With regard to specificity the test is now 98% accurate for IgG and 100% for IgA.

    Case #3: 34-year old female vegan patient with depression and mild cognitive decline

    A 34-year old woman has followed a Vegan lifestyle for 10 years. She has been working long hours and had a lot of stress. In addition, her thyroid was borderline low with high TPO antibodies. A blood test for vitamin D showed vitamin D deficiency. For the past year her energy level was low and she had developed chronic depression. Her physician did a genetic test that found she carried the gene that converts GABA into glutamate. She thinks that she has small intestinal bacterial overgrowth (SIBO). A review of her dietary habits revealed that she ate more cooked foods and less raw food. Her memory is slightly off, her speech not as fluid and she has some cognitive decline.

    Her blood tests showed anti-immunity to RAGE peptides. To put it another way, RAGE stands for “receptor for advanced glycation end products”. When you eat too much overcooked foods you ingest advanced glycation end products. This can have adverse effects on your body, particularly the brain.

    More tests regarding this woman

    Another specific test revealed a blood brain barrier disruption with the presence of anti-brain antibodies. A stool sample was obtained. It showed low Akkermansia, low Faecali bacterium, low Bifido longum and low Bifido adolescentis bacteria. A chemical analysis revealed low butyrate, propionate and acetate. The treating physician concluded that she had a gut dysbiosis and a dysfunctional gut barrier. This has also affected her blood brain barrier. The constellation of symptoms and blood tests explain her clinical condition. She has developed autoantibodies that affect her thyroid gland and her brain because of the antibodies against her RAGE peptides. People can develop Alzheimer’s disease given enough time with exposure to these antibodies. The leaky gut has led to a break-down of her blood brain barrier and exposed her brain to autoimmune antibodies directed against brain cells.

    Treatment of gut dysbiosis

    This patient started a gluten free diet (GFD). But one of the problems of the GFD is that wheat is removed that normally provides 69% inulin and 71% oligofructose, both important prebiotics that are necessary for probiotics to work with. Inulin is contained in beets, leeks, asparagus, onions, garlic and bananas. Oligofructose is contained in chicory root, bananas, onion, and garlic.

    When people consume a typical Western diet, they get between 1 and 4 grams of inulin daily. But others who eat balanced diets get up to 25 to 100 grams of inulin per day. Dr. O’Bryan explained that going on a GFD leads to an altered microbiome.

    Experiment with volunteers to measure the effects of a gluten free diet

    He discussed an experiment on 10 healthy volunteers who were fed a GFD for 1 month.

    The researchers ordere stool samples in the beginning and at the end of the experiment. There was less of the good bacteria and more of the the bad bacteria. This led to a less protective and more inflammatory environment. The remedy for that is to eat 1 root vegetable and 2 other prebiotics per day. The patient on a GFD must supplement with prebiotic-rich foods to prevent this from happening.

    Non-digestible oligosaccharide supplement

    Inulin and oligosaccharides support the intestinal microbiota.  Dr. O’Brien suggested to add a supplement, called Precision Prebiotic™, non-digestible oligosaccharides that can increase microbial diversity. This supplement supports the growth of the healthy bacteria. These are keystone bacteria like Akkermansia muciniphila, Faecal bacterium prausnitzii, and Bifidobacteria.

    Other supportive measures for the gut

    • 1 tablespoon of fermented vegetables like sauerkraut once per day
    • The ingestion of fermented foods increases the beneficial gut bacteria by a factor of 10,000-fold!
    • A 100% spore-based probiotic supplement increases diversity of the gut flora and helps to maintain the gut barrier
    • Sodium butyrate, which comes from fermented food is an important modulator of the central nervous system
    • In addition, sodium butyrate also inhibits pathological gut bacteria and maintains the gastrointestinal balance
    • In neurodegenerative disorders sodium butyrate provides anti-inflammatory and neuroprotective effects
    • Sodium butyrate restores the blood brain barrier
    • Following heart attacks or strokes sodium butyrate promotes tissue repair and recovery through cell survival
    Celiac Disease in Various Disguises

    Celiac Disease in Various Disguises

    Conclusion

    Dr. Tom O’Bryan delivered a lecture at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas on Dec.13, 2019. Wheat allergies have increased in the last decades. Researchers have found that in many people there is a deterioration of the gut flora and a breakdown of the gut barrier. This leads to antibody formation against gluten or gliadin (wheat proteins). This exposes the body to many proteins from the gut. The body reacts by producing antibodies to them. These are also affecting cells in the body as they cross react with body proteins. The inflammation from the autoantibodies cause the blood brain barrier to break down. Now the immune system can produce antibodies against brain tissue. In the past  with an intact blood brain barrier this was not possible.

    Autoantibodies in various life epochs

    At a young age autism can develop because of antibodies against gliadin from wheat. In our youth schizophrenia and depression can occur from gut dysbiosis and a subsequent break down of our blood brain barrier. In old age Alzheimer’s disease develops in 1 out of 3 people due to gut dysbiosis and a breakdown of the blood brain barrier with anti-brain antibodies. Dr. O’Bryan explained how a person can turn this negative spiral around and start a new life without these problems. You can avoid a lot of these diseases by eliminating wheat and processed food from your diet.

    Feb
    22
    2020

    Clinical Applications of the Fasting Mimicking Diet

    Dr. Kurt Hong, professor of clinical medicine spoke about clinical applications of the fasting mimicking diet in Las Vegas. This was at the 27th Annual World Congress on Anti-Aging Medicine on Dec. 14, 2019. Although he spoke on various forms of fasting, he concluded that the fasting mimicking diet had the best results and was most consumer-friendly.

    How we age

    Dr. Hong reviewed the processes of aging. We age, because our cells experience oxidative damage and our telomeres (the end caps of our chromosomes) get shorter in time. We also age, because there are genetic mutations in our cells’ DNA and our mitochondria are aging as well. The mitochondria are the small energy packages inside the cells that give us energy. When people age, they have lost mitochondria, there is less energy that the body makes out of food and we feel chronically tired.

    Above the age of 65 we are also likely to develop diseases of various organs:

    • Heart disease: 31%
    • Cancer: 24%
    • Chronic lung disease (lower respiratory disease): 21%
    • Alzheimer’s disease: 13%
    • Diabetes: 11%

    Women are generally healthier than men and their life expectation is 4 to 5 years longer than that of men.

    Cellular and molecular aging

    Longevity researchers have done mouse experiments and human clinical trials for decades. Dr. Hong asked the question: how much longer could humans live, if we could cure cancer, heart disease, stroke and diabetes? The answer is: 13 years. But if we transfer the animal data to humans it should be 30 years of longer life. Why is there such a discrepancy? The answer is that it is easy to force good lifestyles onto animals, but humans are resistant to changes. Humans have their habits; they like to continue to smoke and eat fast food instead of switching to a healthier Mediterranean diet. Humans also resist a regular exercise program. And they do not want to hear that they should replace missing hormones with bioidentical ones. The result is that we humans will prolong our lives only by less than 50% of what we could achieve.

    The concept of intermittent fasting

    Dr. Hong stated, that ten thousand years ago, people did not always have enough food to eat. They were forced to intermittently fast. That did not mean that they had long life expectancies, as there was no cure for any disease. But one fact was true: the body learnt to rejuvenate itself during periods of fasting. And these longevity genes are still present in our genes. But they will only help us when we actually fast for some periods of time.

    Dr. Hong reviewed what kind of fasting methods are available.

    Prolonged fasting and juice fasting are not among the options. With prolonged fasting electrolyte disturbances become an issue. Juice fasting does not remove enough calories and nutrients. This, however is needed to allow the body to stimulate the longevity genes.

    How fasting diets work

    Dr. Hong explained that there are essentially 5 fasting diets that are effective in regulating the key nutrient sensitive pathways of IGF-1, TOR and PKA. This increases cellular protection and maintenance. It also increases activation of stress resistance pathways and removes and replaces damaged and dysfunctional cells. Finally, a fasting diet also reduces inflammation, which is often the start of disease.

    A review of the 5 fasting diets

    Time-restricted eating (TRE)

    With TRE the person fasts for 12 to 16 hours every day. The person restricts the daily food consumption to a 4- to 12-hour window. The disadvantage is that this fast is done every day. The period of fasting may not be long enough to change the metabolism, where the above-mentioned effects take place.

    Alternate-day fasting  

    This is a 24-hour fast every other day with a 1:1 day eating-fasting cycle. This does not appear to be physiological and is disruptive with regard to social activities.

    5:2 intermittent fasting

    With this fast you fast for 2 days every week. With this 2:5 eating-fasting cycle the person fasts for 2 days every week; the other 5 days you eat as much as you desire.

    Although this is effective, it can be quite disruptive to your lifestyle.

    Periodic fasting

    You fast for 48 to 72 hours every couple of months. This fast is socially more acceptable. It is not that often, just a couple of times in a year. The question remains whether it is effective in changing the metabolism to trigger the effects mentioned above.

    Fasting-mimicking diet (FMD)

    The original suggestion by Dr. Longo, the inventor of the FMD was that you should fast for 5 days once every month. Since then he has modified it and said that you can achieve similar metabolic changes, if you only fast for 3 days and do this a couple of times per year. I have done the FMD since December 2017 and I adhere to the original schedule of doing the FMD monthly for 5 days. This has provided me with more energy. It is easier to keep my body mass index in the 21.0 to 22.0 range. Dr. Hong explained that the FMD allows you to eat, but it tricks the body into acting like you are fasting. Because you are eating 500 to 600 calories per day, you are getting some fluid and nutrients, so the hunger pangs are tolerable.

    More details about the FMD

    Here is Dr. Hong’s summary about the FMD: “The stomach sees food, while the cells see fasting”. Dr. Hong said that the FMD is the most user-friendly method of fasting. It also has had the most scientific studies to validate that it is indeed working. Poorly functioning mitochondria and misfolded proteins are removed by a process of phagocytosis. The FMD reduces heart disease, cancer, and neurodegenerative disorders. Stem cell production also gets a boost. This promotes cell regeneration and reduces risk factors of premature aging.

    Publication on the effectiveness of the FMD

    A publication came out in 2017 reporting about the findings of a clinical trial regarding the FMD.

    Researchers followed markers of aging, diabetes, cancer and cardiovascular disease in 100 volunteers. They underwent a FMD for 5 days on 3 consecutive months. The results were astounding. The body mass index, the fasting blood sugar level, triglycerides, total and LDL cholesterol and the CRP were all lower. CRP stands for C-reactive protein, which measures the degree of inflammation in the body. The blood pressure was also lower. Overall the 5-day FMD was a safe method with no side effects. The FMD reduced markers and risk factors of aging and age-related diseases. In doing so it prolongs life by reducing the likelihood of coming down with disease.

    Who should abstain from fasting?

    Dr. Hong mentioned that the FMD is not for everybody. Pregnant women should refrain from going on it, also type 1 and type 2 insulin dependent diabetics. Anybody who has a sign of an active infection (coughing, having a fever or diarrhea) should be excluded. Other exclusions are people who are underweight (BMI less than 18.5) or are malnourished (protein deficiency). Patients with heart failure and advanced kidney or liver disease should not take part in a fasting program.

    Autoimmune diseases and FMD

    The myelin sheath around the axon of nerve cells in the central nervous system are supported by oligodendrocytes. In multiple sclerosis (MS) patients T lymphocytes activate macrophages and B cells to produce autoantibodies. They destroy oligodendrocytes breaking down the insulating barrier of the myelin sheath. In MS patients the broken-down myelin sheath suppresses the electrical impulses transmitted through the nerve fibers. The FMD led to clinical improvements.

    In a pilot study intermittent fasting changed the gut flora into a healthier flora.

    This triggered the immune system in the gut to make less inflammatory T cells producing the IL-17 cytokines. There was also an increase in regulatory T helper cells.

    Inflammatory bowel disease (IBM) can be improved with several courses of FMD. As the authors showed, intestinal inflammation improved with FMD. The intestinal gut flora improved with the FMD and it promoted intestinal regeneration.

    Reversal of physical and functional decline

    The fasting mimicking diet (FMD) has a variety of effects on the human body. Dr. Hong showed a slide where we could see that ketone bodies, cortisol and ghrelin levels are increased in the blood. At the same time glucose, insulin, leptin and IGF-1 levels are reduced. In addition, triglycerides and LDL levels are getting lower. Inflammatory markers including the C-reactive protein (CRP) are reduced as well.

    Effects of the FMD on various organs in the body

    A look at all of the organs shows that in the liver the ketone body production and insulin sensitivity are up. Glycogen production in the liver as well as the liver size are down.

    The intestines produce ketone bodies. In the skeletal muscles the insulin sensitivity is increased, while the muscle structure and function are improved. In the brain the hunger feeling increases the release of neurotropic factors including the neuropeptide Y. Cognitive function and stress resistance increase with the FMD. The FMD reduces inflammation and oxidative stress in the brain. With respect to the cardiovascular system the heart rate drops down and blood pressure gets lower. The insulin production in the pancreas is reduced.

    Fatty tissue

    In fatty tissue lipolysis is up and also the production of adiponectin. This is a protein hormone involved in glucose and fatty acid metabolism. Insulin sensitivity with the FMD is also increased. On the other hand, the FMD reduces fat mass, leptin production and inflammation.

    The FMD is the solution to preventing disease and prolonging your life

    All of these effects lead to a reversal of physiologic and functional declines. Age-related metabolic diseases like type 2 diabetes are postponed or eliminated. The FMD prevents neuro-cognitive decline like Alzheimer’s disease. In addition, the risk of developing cancer is getting lower. In summary, the FMD improves the health-span, quality of life and can prepare you for a long life.

    Clinical Applications of the Fasting Mimicking Diet

    Clinical Applications of the Fasting Mimicking Diet

    Conclusion

    Dr. Kurt Hong is a professor of clinical medicine at UCLA. He gave a talk at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas on Dec. 14, 2019. He discussed what we could do to help patients with various autoimmune diseases like multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease. It turns out that the fasting mimicking diet (FMD) is the best solution to reduce inflammation and modify  the autoimmune response from aggressive T lymphocytes. With the FMD you consume only 500 to 600 calories per day for 5 days every month. The rest of the days of the month you eat a healthy Mediterranean-type diet.

    Fasting mimicking diet, the best way to treat autoimmune diseases

    Dr. Hong explained in detail what cellular mechanisms are at work to achieve the modification of the immune system in autoimmune diseases. The FMD is also the solution to slow down aging in healthy people. Dr. Hong discussed clinical applications of the fasting mimicking diet fort autoimmune diseases. It is easier to prevent disease than it is to cure an illness. The FMD is an easier way, because you don’t fast completely, you only reduce your food intake to the bare minimum, but your body “thinks” that you are fasting.

    Ultimately, this approach does take some effort, and it does take time to familiarize yourself with it. If patients do it for the first time, they will experience some hunger, the first and second day tend to be a hurdle! Once you make it part of a health routine on a regular basis, it is a lot easier.

    Feb
    15
    2020

    Rheumatoid Arthritis Treatment by Regenerative Medicine

    Dr. David Lans gave a talk at a conference in Las Vegas about rheumatoid arthritis treatment by regenerative medicine. This was at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15th, 2019. The full title of his presentation was “Rheumatoid Arthritis, A Regenerative Medicine Approach”.

    Dr. Lans is a rheumatologist and Assistant Clinical Professor of Medicine at the New York Presbyterian Lawrence Hospital, Bronxville, NY.

    Introduction

    Rheumatoid arthritis is a worldwide immune disorder. About 1% of the general population suffer of this illness with a female to male ratio of 3:1. Typically it can affect  the synovial membranes of all joints. To clarify, the presentation is usually symmetrical, but in 40% of all cases this systemic inflammatory disease can also involve other tissues and organs. 70% of cases have a positive rheumatoid factor (RF) in blood tests. However, a newer, more specific blood test for rheumatoid arthritis is anti-cyclic citrullinated peptide (anti-CCP). Symptoms of rheumatoid arthritis are anemia, fatigue, malaise, joint pain and joint stiffness. Inflammatory blood markers are positive.

    Causes of rheumatoid arthritis

    Genetic causes play an important role in the causation of rheumatoid arthritis. Over 100 genes  can increase due to genetics. Twin studies showed that the concordance rate to develop RA is only 15-20%. Certainly, this means that in order to develop RA you need a double hit: the genetic vulnerability for RA and also an environmental triggering factor. Meanwhile, here is a list of environmental risk factors:

    • Smoking
    • Gum disease (chronic gingivitis)
    • Any chronic infection
    • Dysbiosis in the gut
    • Environmental toxins
    • Heavy metal toxicity
    • Poor diet and nutrition

    In other words, the common denominator to all of these environmental risk factors is the disruption of the mucosal integrity. In fact, this starts the process of chronic inflammation and autoantibodies (like RF and anti-CCP) resulting in chronic synovitis.

    How inflammation travels from mucosal surfaces to the synovium of joints

    Inflammation in gums, lungs or gut can travel via the blood and the lymphatic system into periarticular bone. This leads to bone and cartilage damage. Consequently, the bone destruction leads to chronic synovitis. To emphasize, Dr. Lans said that no patient with rheumatoid arthritis will develop symptoms of RA unless the autoantibodies have developed. In the same vein, there is a distinct preclinical period of RA with positive blood tests for RA, but absent clinical symptoms.

    Prevention of synovitis through a preventative program

    It is important to realize that because of this time relationship there is room for a preventative program where patients are taught the importance of dental hygiene. Another key point is that good health habits and nutrition are also important for prevention. When patients develop early-onset RA, the following measures often help to alleviate the development of symptoms: anti-inflammatory diet, stress management, intermittent fasting, a gut healing program, nutraceuticals like vitamin D3 and fish oil. Herbal therapies are also important like curcumin, Boswellia serrata, devil’s claw, ginger, Ashwagandha and others.

    Conventional medicine approach versus the regenerative medical approach

    To explain, the conventional treatment approach of rheumatoid arthritis is to induce a disease remission with drugs. To this effect doctors use anti-inflammatory drugs like ANSAIDs, disease modifying anti-rheumatic drugs (DMARDs). For example, drugs like methotrexate and sulfosalazine belong into this category. Unfortunately, the conventional drugs have many serious side effects that often make the rheumatoid arthritis patient’s condition worse.

    In contrast, the integrative medicine approach to rheumatoid arthritis is to use dietary measures to reduce the inflammation. The fasting mimicking diet is able to reduce the severity of the inflammation in RA patients.

    Other authors described the use of the Mediterranean diet to reduce inflammation. In addition, there are a number of regenerative methods that help improve the condition of RA patients.

    Regenerative medical treatments for RA patients

    Significantly, platelet rich plasma (PRP), peptides, stem cell therapy and exosomes are some of the modalities that show promise. (I’ll explain the meaning of exosomes later.) In addition, red light therapy and low-level laser therapy can help joint synovitis.

    PRP provides growth factors to repair damaged tissues and is anti-inflammatory. Peptides consist of short chains of amino acids that have anti-inflammatory effects and promote healing of damaged tissues. Thymosin-alpha 1, Thymosin-beta 4, BPC-157, Melanotan II and FOXO4-DRI are examples of peptides used in patients. Special blood tests are used to monitor whether the treatment of RA is successful. These tests are: C-reactive protein, sedimentation rate (ESR) and Vectra. Vectra measures 12 protein markers that are important in RA.

    More info about peptide therapy

    Researchers noticed that peptides are very safe, but they are also very effective. HAP-1 seems to bind to synovial surfaces. RDG peptides work closely together with integrin-binding proteins. Together they have an anti-inflammatory effect in rheumatoid arthritis. They are capable of blocking both the inflammatory and autoimmune components of rheumatoid arthritis. Thymosin-alpha 1 is a peptide with powerful effects as an immune and inflammation modulator. Thymosin-beta 4 is promoting tissue healing. BPC-157 is a peptide with 15 amino acids. It helps with the regeneration of tissue after damage.

    Melanotan II is a synthetic peptide derived from melanocortin, a pituitary hormone. It helps to suppress cytokine-meditated inflammation.

    FOXO4-DRI is a peptide that stimulates the removal of senescent cells. Because of this it is called a senolytic. Researchers are still investigating FOXO4-DRI in humans and for the tissue repair effect in rheumatoid arthritis patients.

    The use of stem cells in RA therapy

    Another biological remedy for treating RA patients is the use of mesenchymal stem cells. In 2013 rheumatoid patients received umbilical cord stem cells to study the effect of stem cells. The clinical trial consisted of 172 patients. In the trial disease modifying anti-rheumatic drugs plus placebo were compared to disease modifying anti-rheumatic drugs plus umbilical cord stem cells (treatment group). In the treatment group inflammatory cytokines were reduced and regulatory T cells were increased. Improvement was assessed with objective clinical measures and blood tests. The improvement lasted between 3 and 6 months.

    Exosome therapy from mesenchymal stem cells 

    Many of the effects of stem cells are explainable by so-called exosomes. They are cell particles shed by stem cells. They contain signalling proteins (integrins), messenger RNA and many other healing substances. The bioactive effects are very diverse. Exosomes are bactericidal, antifungal, stimulate angiogenesis and stimulate tissue regeneration. They are also anti-apoptosis, anti-tumoral, anti-fibrosis, stimulate immunomodulation and cause chemoattraction.

    What does that mean clinically? Exosomes suppress the release of inflammatory cytokines. Anti-inflammatory cytokines (like transforming growth factor beta or TGF-beta) are increased. Exosomes reduce the Th17 cells (T helper cells that produce the inflammatory cytokine IL-17). They also promote osteochondral regeneration, which is important for joint healing in the treatment of RA patients.

    Treatment of RA using the integrative and regenerative medicine approach

    1. The physician assesses all affected joints and orders blood tests to check the inflammatory status.
    2. Identify the triggers that perpetuate the RA disease. Typically there are gut dysbiosis issues that need treatment. Sleep hygiene and stress issues require modification.
    3. Assess the need for disease modifying anti-rheumatic drugs (DMARDs); these are drugs like methotrexate, sulfosalazine and others.
    4. Peptide protocol: BPC-157: 300 micrograms once or twice daily IV; Thymosin alpha: 300 micrograms once or twice daily IV; Thymosin beta: 100 to 300 micrograms once daily IV, limit to 3-month cycle.
    5. Mesenchymal stem cell therapy and exosomes.
    Rheumatoid Arthritis Treatment by Regenerative Medicine

    Rheumatoid Arthritis Treatment by Regenerative Medicine

    Conclusion

    Rheumatoid arthritis is a common autoimmune disease, which leaves the patient disabled, if she receives no treatment for it. Conventional rheumatologist protocols treat the inflammation with various drugs, but they cause a lot of side effects.

    There is an emergence of regenerative therapies that may be able to help treat the inflammation of the rheumatoid arthritis patient with less side effects. At the same time these treatments can also help to repair the damaged tissues. There is a great need for more clinical studies. Current human data are limited. Safe options to treat RA patients are mesenchymal stem cell therapy, exosome treatment and peptide therapies. The approach of the physician depends on the clinical stage the patient is in. It is common sense that early diagnosis and treatment will have better results. Also, an integrative approach has the best chance to help the patient with the least side-effects.

    Feb
    08
    2020

    Two Clinical Cases Demonstrating the Healing Effects of Peptides

    Dr. Joseph Cleaver gave a talk about two clinical cases demonstrating the healing effects of peptides. His presentation on Dec. 13, 2019 was part of the 27th Annual World Congress on Anti-Aging Medicine. The topic of his talk was “The Power of Peptides – Treatment of End Stage Renal Disease and Congestive Heart Failure, Case Studies “. Dr. Cleaver presented how his 86-year old father who had end stage kidney disease was able to go home from a palliative care facility following peptide treatment.

    Next he presented another case of a 51-old man who had sustained a viral cardiomyopathy 7 years earlier. His cardiac condition had recently deteriorated, and his physicians put him on an urgent heart transplant list. After only 3 weeks of the peptide therapy he was taken off the heart transplant list as his condition had improved so much.

    The medical team

    Both patients received initial treatment by a conventional medical team. In the case of the 86-year old man treatment consisted of draining fluid from both lung areas and doing dialysis for chronic kidney failure. Otherwise the family received the sad news that nothing more was available to help, and he was discharged to the palliative care unit. Similarly, the 51-year old man with an end stage heart condition received conventional treatment and learned that the only other possibility to help him was a heart transplant.

    The integrative medicine team that treated both patients later consisted of Dr. Mark Houston, an integrative cardiologist. In addition, there was Dr. Joseph Cleaver, one of the leaders in peptide therapy. The third person was Dr. Andrew Heyman, an expert in integrative medicine.

    An 86-year old patient with end-stage kidney failure

    Dr. Cleaver said that in May 2019 he received a phone call from the emergency room doctor of the hospital. He said that his father was admitted with serious heart problems and was deteriorating rapidly. He had a history of a multiple myeloma with abnormal deposits called amyloidosis. This material formed deposits in his brain and his heart muscle. As a result, he had developed a weakening of the heart resulting in fluid collection in his lungs. Just recently, on April 3, 2019 two stents were placed in his coronary arteries because of hardening of the heart vessels. He also had chronic renal failure with a very low glomerular filtration rate (GFR), which is a measure of the severity of the condition. The GFR was only 15 meaning that he needed 5 dialysis treatments per week to keep him alive.

    Findings in the emergency department

    An echocardiogram of the heart confirmed amyloidosis of his heart. He had an effusion around the heart, called pericardial effusion. He also had pleural effusions in both lungs. A further test confirmed kidney failure. He needed daily dialysis treatments to combat the kidney failure. The physicians removed 1600 ml of fluid from both lung cavities. Drug therapy was started to improve his heart failure. He required antibiotics for the beginning of blood poisoning (sepsis). By mid-June he had stabilized and his treatment team sent him to palliative care. The purpose of the transfer was to have another medical team look after him for end of life care.

    Dr. Cleaver consulted with his integrative medicine collogues to discuss options of integrative medicine treatment of his father.

    Integrative medicine approach to treat kidney failure

    On June 10, 2019 the integrative medicine specialists ordered to start therapy with the peptide TB4. TB4 stands for thymosin beta 4. It can reduce infarct size in people with heart attacks. But it can also improve heart muscle function in general.

    Another peptide was started on June 10, 2019, namely BPC-157. The doctors ordered this to repair organ damage.

    He also received general nutraceutical supplements including the mitochondrial antioxidant MitoQuinol.

    Results of integrative treatment

    Dr. Cleaver’s father was able to return home in August 2019. His grip strength, gait and general strength were the best he has been in years. He returned to wood working (building furniture). He lifts weights and uses an exercise bike every day. His chronic lower back pain has mostly disappeared. His gait is strong and his balance has improved. He maintains his kidney function with only one dialysis treatment per week. He is looking after his garden, walks without assistance and enjoys spending time with his wife. His heart function has normalized and there is significant improvement in his kidney function.

    A 51-old man with viral cardiomyopathy waiting for a heart transplant

    The second clinical case that Dr. Cleaver presented was that of a 51-year old man who had contracted a viral cardiomyopathy 7 years earlier. His heart function had slowly deteriorated since then. The doctors had nothing else to offer him with his heart condition except to put him on a waiting list for a heart transplant. His symptoms were shortness of breath and fatigue. In addition he required two pillows for sleeping to cope with his shortness of breath.

    Integrative medicine approach to treat heart failure

    Here is what the treatment plan from the integrative medicine team for this patient included.

    The team concentrated on heart muscle cell regeneration and reconditioning of the cardiac mitochondria. The main peptides used were BPC-157 and thymosin beta 4. Another peptide was Ipamorelin, which is known to release growth hormone. Human growth hormone has been shown to improve heart function in patients with heart failure.

    The doctors also ordered CoQ-10 and MitoQuinol to stimulate the mitochondria of the heart muscle. In their search for effective alternative remedies for cardiomyopathy the integrative medicine team found supportive literature. They found that growth hormone releasing hormone and Ipamorelin were stimulating receptors on cardiac stem cells. This stimulates survival of heart muscle fibers and modulates genes that regulate cardiac remodelling. The team also administered Hexarelin and ghrelin, which release growth hormone in the body.

    Within only three weeks this patient’s shortness of breath disappeared. His ejection fraction, a measure of left heart chamber contraction normalized. He felt energy and no longer needed two pillows to sleep. Due to his improvement his doctor took him off the heart transplant list.

    Discussion

    These two cases demonstrate the limits of conventional medicine. Chronic kidney failure and chronic heart failure are conditions for which the normal health care system has no answers. But interestingly, the integrative medicine team managed using innovative peptides that helped in both of these cases. Dr. Cleaver reminded us that we should not only trust in conventional medicine, particularly when there is no positive result. Integrative medicine can offer alternative approaches for the difficult cases that conventional medicine cannot solve. At this point we do not know all the mechanisms of why peptides are helping. Some papers point out that peptides may stimulate pluripotent stem cells to heal whatever condition it is in the body. Dr. Cleaver provided extensive literature references regarding several peptides that are now in clinical use.

    Two Clinical Cases Demonstrating the Healing Effects of Peptides

    Two Clinical Cases Demonstrating the Healing Effects of Peptides

    Conclusion

    Dr. Cleaver gave a talk about peptides at the 27th Annual World Congress on Anti-Aging Medicine on Dec. 13, 2019. He presented two clinical examples, which could not be dealt with by conventional medicine. The first was an 86-year old patient with end-stage kidney failure. The second was a 51-old man with viral cardiomyopathy waiting for a heart transplant. Miraculously, both cases responded to peptide therapy with TB4 (thymosin beta 4) and BPC157. Within a matter of a few weeks there was clinical improvement in both cases. The 86-year old man could return home from a palliative care home, attend to his garden and do woodworking. The 51-year old man regained his cardiac strength and his physician took him off the heart transplant list. Integrative medicine can be useful in chronic cases that conventional medicine cannot improve.

    Feb
    01
    2020

    About the Opioid Epidemic

    Dr. Anna Lembke gave a talk about the opioid epidemic on Dec. 13, 2019. This was at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15th, 2019. The full title of her presentation was “From Freud to Fentanyl: Update on the Opioid Epidemic.” Dr. Lembke is an associate professor at the Stanford University School of Medicine. From 1999 to 2010 opioid sales went up 6-fold. Opioid treatment admissions and opioid deaths have risen 5-fold in the same time period. Physicians prescribe too many opioid pills. One slide summarized how patients got opioid pills. 53% had pain pills given by friends for free or bought opioids from them. 37.5% received pain pills from a doctor by prescription. 6% bought pain pills from a drug dealer or a stranger. In about 3.4% it was not traceable how the persons using drugs obtained them.

    Compassionate doctor and drug-seeking patient

    The doctor went through medical school wanting to care about patients. Compassion to help is a powerful motivating force. On the other hand, most patients are glad that the physician wants to help and they do their part to contribute to healing. Except, there is a small percentage of patients who take advantage of a soft-hearted physician. They will demand prescriptions, even if they are not in pain. They may do this to sell the drugs to get some extra income. Others take more pills than what the doctor  prescribed, because they want to get high on the drugs. Patients who have an addiction to pain pills, have a process in their brain, called neuroadaptation. Whenever the dosage in the blood goes down, they are now adapted to taking more pills.

    About the opioid epidemic and the role of Big Pharma

    Pharmaceutical marketing spent more than 26 billion USD in 2012. This consisted of drug representatives visiting doctor’s offices and giving hand-outs of free samples to physicians. There were promotional mailings, advertisements, direct-to-consumer advertising and educational and promotional meetings. In addition, pharmaceutical marketing included sponsoring clinical trials. In 1980 there was still an opinion that pain drugs would be harmless and in the majority of cases would not be the cause for abuse.

    Purdue Pharma, the producer of the pain pill OxyContin, was caught in secretly pushing the sales of OxyContin in order to sell more of their drug suboxone, which helps with drug withdrawal.

    A law suit against Purdue Pharma brought the  “project Tango” to light.

    Three myths about drug addiction

    Myth #1: Opioids work for chronic pain

    The pain pill producers have been pushing for the concept that pain pills would work for chronic pain. However, clinical studies showed that pain pills will only work for acute pain and when it becomes chronic pain, pills against pain become less reliable. People who take pain pills for chronic pain enter into a vicious cycle. They need to take more pain pills to experience relief from pain. But they often do not realize that the drug withdrawal pain is what gets them into seeking more drugs.

    Purdue stated this:“We now know that many patients with chronic, non-malignant pain respond very well to opioids. The barriers to vastly improved treatment for hundreds of thousands of people in pain, are simply the misinformation and prejudice of doctors, pharmacists and regulatory bodies.” Purdue Physicians’ Pain Management Speaker Training Program, April 1997

    Myth #2: When it comes to opioids, no dose is too high and no duration is too long

    This reflects what Purdue says to increase its pain medication sales.“Opioids are effective, easily titrated, and have a favorable benefit-to-risk ratio. Large doses of opioids may be necessary to control pain if it is severe, and extended courses may be necessary if the pain is chronic.” Purdue Physicians’ Pain Management Speaker Training Program, April 1997

    Evidence from unbiased researchers show that opioids taken in high doses and taken over long periods of time harm patients.

    Patients develop cardiac arrhythmias, depression and may commit suicide. Other symptoms are  constipation, addiction, cognitive impairment, hormonal imbalances and  death. In addition, opioids can cause an annoying skin hypersensitivity.

    Research further showed that gradual opioid withdrawal improves chronic pain (2017 study by Frank et al.)

    Myth # 3: Less than 1% will get addicted to pain pills

    Purdue stated:
    “Contrary to our teaching, addiction is very rare and possibly nonexistent as a result of treating such patients with opioids.” Purdue Physicians’ Pain Management Speaker Training Program, April 1997

    Here is the truth: A meta-analysis of 38 studies showed that people abused pain pills on average between 21 and 29%. Addiction rates were between 8% and 12%. These figures likely are under estimates. The authors said that the real figure of opioid abuse is likely about 40%.

    Poor people treated differently

    Poor people on Medicaid in the US receive twice the rate of opioids as do non-Medicaid patients. But Medicaid patients die at 6-times the rate from prescription overdoses. Often patients receive a prescription for pain pills and also a prescription for benzodiazepines. The doctor prescribes benzodiazepines for sleep problems or anxiety. Drug interactions of two potentially addicting drugs likely are more detrimental on the long-term.

    Examples of a doctor’s visit (YouTube display)

    Dr. Lembke played a YouTube video where she was role-playing her previous behavior as a supportive physician who prescribed opioids to patients (drug-seeking patient and supportive physician).

    However, she said that she learnt from experience. In the meantime, when she finds out from a computer program that a patient is deceiving her, she behaves differently (doctor non-supportive towards a doctor-shopping drug addict).

    About the Opioid Epidemic

    About the Opioid Epidemic

    Conclusion about the opioid epidemic 

    The topic of opioid addiction is multifaceted. I summarized a lecture presented at the 27th Annual World Congress on Anti-Aging Medicine in Las Vegas from Dec. 13 to 15th, 2019 by Dr. Lembke. She talked about the opioid epidemic and the difficulties keeping the science of opioids separated from the marketing by Big Pharma. Three myths of Big Pharma were analyzed and on every occasion the truth was the opposite of the myth. Chronic pain does not respond to opioids, yet many physicians keep on prescribing these drugs. Medicaid does not help poor patients. They get twice the opioid prescriptions as non-Medicaid patients get. But Medicaid patients die at 6-times the rate from prescription overdoses. There are many unanswered questions regarding opioids. Hopefully, more judicious prescribing by physicians and alternative ways of treating pain by chiropractors, physiotherapist and acupuncturists will gradually improve the situation.